Search

Your search keyword '"Benoit, Sandrine"' showing total 190 results
Start Over Author "Benoit, Sandrine"
190 results on '"Benoit, Sandrine"'

1. Characterization of the skin microbiota in bullous pemphigoid patients and controls reveals novel microbial indicators of disease

Author

Belheouane, Meriem, Hermes, Britt M., Van Beek, Nina, Benoit, Sandrine, Bernard, Philippe, Drenovska, Kossara, Gerdes, Sascha, Gläser, Regine, Goebeler, Matthias, Günther, Claudia, von Georg, Anabelle, Hammers, Christoph M., Holtsche, Maike M., Homey, Bernhard, Horváth, Orsolya N., Hübner, Franziska, Linnemann, Beke, Joly, Pascal, Márton, Dalma, Patsatsi, Aikaterini, Pföhler, Claudia, Sárdy, Miklós, Huilaja, Laura, Vassileva, Snejina, Zillikens, Detlef, Ibrahim, Saleh, Sadik, Christian D., Schmidt, Enno, and Baines, John F.

Published
2023
Full Text
View/download PDF

3. Efficacy and safety of adjuvant immunoadsorption in pemphigus vulgaris and pemphigus foliaceus (IA-Pem Study): a multicentre randomized controlled trial.

Author

Beek, Nina van, Eming, Rüdiger, Reuss, Alexander, Zillikens, Detlef, Sárdy, Miklós, Günther, Claudia, Kiritsi, Dimitra, Benoit, Sandrine, Beissert, Stefan, Gläser, Regine, Gollnick, Harald, Horváth, Orsolya N, Pfeiffer, Christiane, Röcken, Martin, Schauer, Franziska, Schreml, Stephan, Steinbrink, Kerstin, Zink, Alexander, Schade-Brittinger, Carmen, and Hertl, Michael

Subjects
PEMPHIGUS vulgaris, IMMUNOADSORPTION, RANDOMIZED controlled trials, PEMPHIGUS, PATIENTS, AUTOIMMUNE diseases, DISEASE remission
Abstract

Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially life-threatening autoimmune blistering diseases. Treatment is based on long-term immunosuppression with high doses of glucocorticosteroids in combination with potentially corticosteroid-sparing agents and/or rituximab. Immunoadsorption (IA) has emerged as a fast-acting adjuvant treatment option. Objectives To assess the clinical efficacy of IA in addition to best medical treatment (BMT). Methods We conducted a multicentre (26 centres from Germany and Austria) randomized controlled trial in 72 patients with newly diagnosed, relapsed or chronic active PV or PF (34 female patients and 38 male patients, aged 42–72   years) comparing BMT (prednisolone 1.0   mg kg−1 per day plus azathioprine or mycophenolate) with adjuvant IA (BMT + IA). Central 1 : 1 randomization was done at the coordinating centre for clinical trials (KKS Marburg). The primary endpoint was analysed using Kaplan–Meier and Cox regression methods. Results The study was ended prematurely owing to safety concerns after random allocation of 72 patients to BMT + IA (n = 34) or BMT (n = 38). The primary endpoint, time to complete remission on therapy, was not significantly different for the two groups [hazard ratio (HR) 1.35, 95% confidence interval (CI) 0.68–2.69; P = 0.39]. The cumulative dose of prednisolone was significantly lower in the BMT + IA group compared with BMT alone (difference −1214, 95% CI −2225 to −70; P = 0.03). In a post hoc analysis, patients with more extensive PV/PF showed a tendency towards a shorter time to remission in the BMT + IA group compared with the BMT group (HR 1.87, P = 0.17 in patients with baseline Pemphigus Disease Area Index ≥ 15). While more adverse events were observed in patients in the BMT group (29 vs. 25), severe adverse events were more frequent in patients in the BMT + IA group (17 events in 10 patients vs. 11 events in 8 patients). Conclusions In this study, adjuvant IA did not demonstrate a shorter time to clinical remission, but a corticosteroid-sparing effect was observed. In patients with extensive PV/PF, post hoc analysis suggests that adjuvant IA may lead to earlier remission, but potential adverse events must be carefully weighed against the expected benefits. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Efficacy and safety of adjuvant immunoadsorption in pemphigus vulgaris and pemphigus foliaceus (IA-Pem Study): a multicentre randomised controlled trial

Author

van Beek, Nina, primary, Eming, Rüdiger, additional, Reuss, Alexander, additional, Zillikens, Detlef, additional, Sárdy, Miklós, additional, Günther, Claudia, additional, Kiritsi, Dimitra, additional, Benoit, Sandrine, additional, Beissert, Stefan, additional, Gläser, Regine, additional, Gollnick, Harald, additional, Horváth, Orsolya N, additional, Pfeiffer, Christiane, additional, Röcken, Martin, additional, Schauer, Franziska, additional, Schreml, Stephan, additional, Steinbrink, Kerstin, additional, Zink, Alexander, additional, Schade-Brittinger, Carmen, additional, Hertl, Michael, additional, and Schmidt, Enno, additional

Published
2023
Full Text
View/download PDF

5. The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility

Author

Liu, Xiaolin, primary, van Beek, Nina, additional, Cepic, Aleksa, additional, Andreani, Nadia A., additional, Chung, Cecilia J., additional, Hermes, Britt M., additional, Yilmaz, Kaan, additional, Benoit, Sandrine, additional, Drenovska, Kossara, additional, Gerdes, Sascha, additional, Gläser, Regine, additional, Goebeler, Matthias, additional, Günther, Claudia, additional, von Georg, Anabelle, additional, Hammers, Christoph M., additional, Holtsche, Maike M., additional, Hübner, Franziska, additional, Kiritsi, Dimitra, additional, Schauer, Franziska, additional, Linnenmann, Beke, additional, Huilaja, Laura, additional, Tasanen-Määttä, Kaisa, additional, Vassileva, Snejina, additional, Zillikens, Detlef, additional, Sadik, Christian D., additional, Schmidt, Enno, additional, Ibrahim, Saleh, additional, and Baines, John F., additional

Published
2023
Full Text
View/download PDF

10. The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility.

Author

Xiaolin Liu, van Beek, Nina, Cepic, Aleksa, Andreani, Nadia A., Chung, Cecilia J., Hermes, Britt M., Yilmaz, Kaan, Benoit, Sandrine, Drenovska, Kossara, Gerdes, Sascha, Gläser, Regine, Goebeler, Matthias, Günther, Claudia, von Georg, Anabelle, Hammers, Christoph M., Holtsche, Maike M., Hübner, Franziska, Kiritsi, Dimitra, Schauer, Franziska, and Linnenmann, Beke

Subjects
BULLOUS pemphigoid, GUT microbiome, DISEASE susceptibility, SHOTGUN sequencing, GABA, SKIN diseases
Abstract

Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects the elderly. An altered skin microbiota in BP was recently revealed. Accumulating evidence points toward a link between the gut microbiota and skin diseases; however, the gut microbiota composition of BP patients remains largely underexplored, with only one pilot study to date, with a very limited sample size and no functional profiling of gut microbiota. To thoroughly investigate the composition and function of the gut microbiota in BP patients, and explore possible links between skin conditions and gut microbiota, we here investigated the gut microbiota of 66 patients (81.8% firstly diagnosed) suffering from BP and 66 age-, sex-, and study center-matched controls (CL) with non-inflammatory skin diseases (132 total participants), using 16S rRNA gene and shotgun sequencing data. Decreased alpha-diversity and an overall altered gut microbial community is observed in BP patients. Similar trends are observed in subclassifications of BP patients, including first diagnoses and relapsed cases. Furthermore, we observe a set of BP disease-associated gut microbial features, including reduced Faecalibacterium prausnitzii and greater abundance of pathways related to gamma-aminobutyric acid (GABA) metabolism in BP patients. Interestingly, F. prausnitzii is a well-known microbiomarker of inflammatory diseases, which has been reported to be reduced in the gut microbiome of atopic dermatitis and psoriasis patients. Moreover, GABA plays multiple roles in maintaining skin health, including the inhibition of itching by acting as a neurotransmitter, attenuating skin lesions by balancing Th1 and Th2 levels, and maintaining skin elasticity by increasing the expression of type I collagen. These findings thus suggest that gut microbiota alterations present in BP may play a role in the disease, and certain key microbes and functions may contribute to the link between gut dysbiosis and BP disease activity. Further studies to investigate the underlying mechanisms of the gut-skin interaction are thus clearly warranted, which could aid in the development of potential therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

13. Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus

Author

Dettmann, Inga M., Krüger, Stine, Fuhrmann, Tarek, Rentzsch, Kristin, Karl, Ingolf, Probst, Christian, Komorowski, Lars, Fechner, Kai, van Beek, Nina, Lemcke, Susanne, Sárdy, Miklós, Bangert, Christine, Benoit, Sandrine, Hashimoto, Takashi, Zillikens, Detlef, Pas, Hendri H., Jonkman, Marcel F., Stöcker, Winfried, and Schmidt, Enno

Published
2017
Full Text
View/download PDF

14. Genomewide association study identifies GALC as susceptibility gene for mucous membrane pemphigoid

Author

Sadik, Christian D., Bischof, Julia, van Beek, Nina, Dieterich, Anabelle, Benoit, Sandrine, Sárdy, Miklós, Worm, Margitta, Meller, Stephan, Gläser, Regine, Zillikens, Detlef, Homey, Bernhard, Setterfield, Jane, Minassian, Darwin, Schmidt, Enno, Dart, John, Ibrahim, Saleh M., Booth, Debbie, Reid, Elaina, Carnt, Nicole, Gugliemetti, Stefano, Shanmuganathan, Vijay, Watson, Martin, Saw, Valerie, Wilkins, Mark, McCudden, Vicky, Ahmad, Saj, Bunce, Catey, Günther, Claudia, Hadaschik, Eva, Pföhler, Claudia, Schmieder, Astrid, Steinbrink, Kerstin, and Sticherling, Michael

Published
2017
Full Text
View/download PDF

25. Polymorphisms in the mitochondrially encoded ATP synthase 8 gene are associated with susceptibility to bullous pemphigoid in the German population

Author

Hirose, Misa, Schilf, Paul, Benoit, Sandrine, Eming, Rüdiger, Gläser, Regine, Homey, Bernhard, Kunz, Manfred, Nebel, Almut, Peitsch, Wiebke K., Pföhler, Claudia, Sárdy, Miklós, Schreiber, Stefan, Zillikens, Detlef, Schmidt, Enno, Ibrahim, Saleh M., Däschlein, Georg, Goebeler, Matthias, Goetze, Steven, Günther, Claudia, Hadaschik, Eva, Hunzelmann, Nicolas, Kreuter, Alexander, Lippert, Undine, Sticherling, Michael, and Worm, Margitta

Published
2015
Full Text
View/download PDF

26. Characterization of the skin microbiota in bullous pemphigoid patients and controls reveals novel microbial indicators of disease

Author

Belheouane, Meriem, primary, Hermes, Britt M., additional, Van Beek, Nina, additional, Benoit, Sandrine, additional, Bernard, Philippe, additional, Drenovska, Kossara, additional, Gerdes, Sascha, additional, Gläser, Regine, additional, Goebeler, Matthias, additional, Günther, Claudia, additional, von Georg, Anabelle, additional, Hammers, Christoph M., additional, Holtsche, Maike M., additional, Homey, Bernhard, additional, Horváth, Orsolya N., additional, Hübner, Franziska, additional, Linnemann, Beke, additional, Joly, Pascal, additional, Márton, Dalma, additional, Patsatsi, Aikaterini, additional, Pföhler, Claudia, additional, Sárdy, Miklós, additional, Huilaja, Laura, additional, Vassileva, Snejina, additional, Zillikens, Detlef, additional, Ibrahim, Saleh, additional, Sadik, Christian D., additional, Schmidt, Enno, additional, and Baines, John F., additional

Published
2021
Full Text
View/download PDF

27. Additional file 1 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans

Author

Schwarm, Christian, Gola, Damian, Holtsche, Maike M., Dieterich, Anabelle, Bhandari, Anita, Freitag, Miriam, Nürnberg, Peter, Toliat, Mohammad, Lieb, Wolfgang, Wittig, Michael, Franke, André, Worm, Margitta, Sticherling, Michael, Ehrchen, Jan, Günther, Claudia, Gläser, Regine, Peitsch, Wiebke K., Sárdy, Miklós, Eming, Rüdiger, Hertl, Michael, Benoit, Sandrine, Goebeler, Matthias, Pföhler, Claudia, Kunz, Manfred, Kreuter, Alexander, Van Beek, Nina, Erdmann, Jeanette, Busch, Hauke, Zillikens, Detlef, Sadik, Christian D., Hirose, Misa, König, Inke R., Schmidt, Enno, and Ibrahim, Saleh M.

Abstract

Additional file 1. Materials and methods. References. Table 1: The age range of samples used in this study. Table 2: Sample numbers of the BP GWAS cohorts. Table 3: Distribution of posterior probabilities of imputed HLA alleles.

Published
2021
Full Text
View/download PDF

28. Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and-DRB1*07:01, in Germans

Author

Schwarm, Christian, Gola, Damian, Holtsche, Maike M., Dieterich, Anabelle, Bhandari, Anita, Freitag, Miriam, Nuernberg, Peter, Toliat, Mohammad, Lieb, Wolfgang, Wittig, Michael, Franke, Andre, Worm, Margitta, Sticherling, Michael, Ehrchen, Jan, Guenther, Claudia, Glaeser, Regine, Peitsch, Wiebke K., Sardy, Miklos, Eming, Ruediger, Hertl, Michael, Benoit, Sandrine, Goebeler, Matthias, Pfoehler, Claudia, Kunz, Manfred, Kreuter, Alexander, van Beek, Nina, Erdmann, Jeanette, Busch, Hauke, Zillikens, Detlef, Sadik, Christian D., Hirose, Misa, Koenig, Inke R., Schmidt, Enno, Ibrahim, Saleh M., Schwarm, Christian, Gola, Damian, Holtsche, Maike M., Dieterich, Anabelle, Bhandari, Anita, Freitag, Miriam, Nuernberg, Peter, Toliat, Mohammad, Lieb, Wolfgang, Wittig, Michael, Franke, Andre, Worm, Margitta, Sticherling, Michael, Ehrchen, Jan, Guenther, Claudia, Glaeser, Regine, Peitsch, Wiebke K., Sardy, Miklos, Eming, Ruediger, Hertl, Michael, Benoit, Sandrine, Goebeler, Matthias, Pfoehler, Claudia, Kunz, Manfred, Kreuter, Alexander, van Beek, Nina, Erdmann, Jeanette, Busch, Hauke, Zillikens, Detlef, Sadik, Christian D., Hirose, Misa, Koenig, Inke R., Schmidt, Enno, and Ibrahim, Saleh M.

Abstract

Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the first genome-wide association study (GWAS) in Germans. This GWAS was combined with HLA locus targeted sequencing in an additional independent BP cohort. The strongest association with BP in Germans tested in this study was observed in the two HLA loci, HLA-DQA1*05:05 and HLA-DRB1*07:01. Further studies with increased sample sizes and complex studies integrating multiple pathogenic drivers will be conducted.

Published
2021

33. Diagnostics of autoimmune bullous diseases in German dermatology departments

Author

van Beek, Nina, Knuth-Rehr, Diana, Altmeyer, Peter, Assaf, Chalid, Babilas, Philipp, Bayerl, Christiane, Benoit, Sandrine, Dippel, Edgar, Effendy, Isaak, Eming, Rüdiger, Fischer, Matthias, Glaenz, Thomas, Gläser, Regine, Goebeler, Matthias, Gollnick, Harald, Götze, Steven, Gross, Gerd, Hadaschik, Eva, Herbst, Rudolf, Hermes, Barbara, Homey, Bernhard, Hunzelmann, Nico, Jünger, Michael, Kapp, Alexander, Kern, Johannes S., Körber, Andreas, Luger, Thomas, Mechtel, Dirk, Megahed, Mosaad, Moll, Ingrid, Peters, Klaus-Peter, Pfeiffer, Christiane, Ring, Johannes, Röcken, Martin, Sárdy, Miklós, Seitz, Cornelia S., Stadler, Rudolf, Steinbrink, Kerstin, Sticherling, Michael, Szeimies, Rolf-Markus, Tronnier, Michael, Ulrich, Jens, Vogt, Thomas, Wagner, Nicola, Welzel, Julia, Wenzel, Jörg, Wozel, Gottfried, Zouboulis, Christos C., Zillikens, Detlef, and Schmidt, Enno

Published
2012
Full Text
View/download PDF

34. Diagnostik blasenbildender Autoimmundermatosen an deutschen Hautkliniken: Diagnostic of autoimmune bullous diseases in German dermatology departments

Author

van Beek, Nina, Knuth-Rehr, Diana, Altmeyer, Peter, Assaf, Chalid, Babilas, Philipp, Bayerl, Christiane, Benoit, Sandrine, Dippel, Edgar, Effendy, Isaak, Eming, Rüdiger, Fischer, Matthias, Glaenz, Thomas, Gläser, Regine, Goebeler, Matthias, Gollnick, Harald, Götze, Steven, Gross, Gerd, Hadaschik, Eva, Herbst, Rudolf, Hermes, Barbara, Homey, Bernhard, Hunzelmann, Nico, Jünger, Michael, Kapp, Alexander, Kern, Johannes S., Körber, Andreas, Luger, Thomas, Mechtel, Dirk, Megahed, Mosaad, Moll, Ingrid, Peters, Klaus-Peter, Pfeiffer, Christiane, Ring, Johannes, Röcken, Martin, Sárdy, Miklós, Seitz, Cornelia S., Stadler, Rudolf, Steinbrink, Kerstin, Sticherling, Michael, Szeimies, Rolf-Markus, Tronnier, Michael, Ulrich, Jens, Vogt, Thomas, Wagner, Nicola, Welzel, Julia, Wenzel, Jörg, Wozel, Gottfried, Zouboulis, Christos C., Zillikens, Detlef, and Schmidt, Enno

Published
2012
Full Text
View/download PDF

37. Polymorphisms in the Mitochondrial Genome Are Associated With Bullous Pemphigoid in Germans

Author

Russlies, Juliane, primary, Fähnrich, Anke, additional, Witte, Mareike, additional, Yin, Junping, additional, Benoit, Sandrine, additional, Gläser, Regine, additional, Günter, Claudia, additional, Eming, Rüdiger, additional, Erdmann, Jeanette, additional, Gola, Damian, additional, Gupta, Yask, additional, Holtsche, Maike Marleen, additional, Kern, Johannes S., additional, König, Inke R., additional, Kiritsi, Dimitra, additional, Lieb, Wolfgang, additional, Sadik, Christian D., additional, Sárdy, Miklós, additional, Schauer, Franziska, additional, van Beek, Nina, additional, Weidinger, Anke, additional, Worm, Margitta, additional, Zillikens, Detlef, additional, Schmidt, Enno, additional, Busch, Hauke, additional, Ibrahim, Saleh M., additional, and Hirose, Misa, additional

Published
2019
Full Text
View/download PDF

43. Vasculitis in childhood - a dermatological approach

Author

Matthias Goebeler and Benoit Sandrine

Subjects
medicine.medical_specialty, Pathology, Respiratory tract infections, business.industry, Acute hemorrhagic edema of infancy, Dermatology, medicine.disease, Purpura, IgA vasculitis, medicine, Kawasaki disease, medicine.symptom, business, Vasculitis, Palpable purpura, Rare disease
Abstract

Summary Vasculitis, an inflammatory condition affecting the blood vessels, may be restricted to a single organ or involve several organ systems. The size of the involved vessels is an important criterion for categorization of vasculitides, which is a prerequisite for rapid diagnosis and initiation of treatment. In pediatric patients, this particularly applies to Kawasaki disease. However, making the diagnosis can be challenging for dermatologists as skin involvement may be variable and non-specific. In contrast, Henoch-Schonlein purpura (IgA vasculitis) presents with the classic picture of palpable purpura. It predominantly affects postcapillary venules frequently following upper respiratory tract infections. Severe organ involvement is relatively rare in children and the prognosis is good. As renal involvement may occur during the course of disease, continuous monitoring is required. Acute hemorrhagic edema of infancy is considered as a distinct type of immune complex vasculitis and is characterized by a triad of fever, edema and rosette-shaped purpura. The clinical course of this rare disease is usually benign and self-limited. Due to the variability of clinical symptoms and manifestations, management of childhood vasculitides represents a special challenge requiring interdisciplinary collaboration. Dermatologists should be aware of their important role especially for making an early diagnosis.

Published
2013

49. Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis

Author

Almanzar, Giovanni, primary, Klein, Matthias, additional, Schmalzing, Marc, additional, Hilligardt, Deborah, additional, El Hajj, Nady, additional, Kneitz, Hermann, additional, Wild, Vanessa, additional, Rosenwald, Andreas, additional, Benoit, Sandrine, additional, Hamm, Henning, additional, Tony, Hans-Peter, additional, Haaf, Thomas, additional, Goebeler, Matthias, additional, and Prelog, Martina, additional

Published
2016
Full Text
View/download PDF

50. Vasculitis in childhood – a dermatological approach

Author

Benoit, Sandrine and Matthias, Goebeler

Subjects
Diagnosis, Differential, Male, Child, Preschool, Humans, Vasculitis, Leukocytoclastic, Cutaneous, Female, Child, Skin Diseases
Abstract

Vasculitis, an inflammatory condition affecting the blood vessels, may be restricted to a single organ or involve several organ systems. The size of the involved vessels is an important criterion for categorization of vasculitides, which is a prerequisite for rapid diagnosis and initiation of treatment. In pediatric patients, this particularly applies to Kawasaki disease. However, making the diagnosis can be challenging for dermatologists as skin involvement may be variable and non-specific. In contrast, Henoch-Schönlein purpura (IgA vasculitis) presents with the classic picture of palpable purpura. It predominantly affects postcapillary venules frequently following upper respiratory tract infections. Severe organ involvement is relatively rare in children and the prognosis is good. As renal involvement may occur during the course of disease, continuous monitoring is required. Acute hemorrhagic edema of infancy is considered as a distinct type of immune complex vasculitis and is characterized by a triad of fever, edema and rosette-shaped purpura. The clinical course of this rare disease is usually benign and self-limited. Due to the variability of clinical symptoms and manifestations, management of childhood vasculitides represents a special challenge requiring interdisciplinary collaboration. Dermatologists should be aware of their important role especially for making an early diagnosis.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results