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4. HIV Infection and Carotid Artery Intima-media Thickness: Pooled Analyses Across 5 Cohorts of the NHLBI HIV-CVD Collaborative

Author

Hanna, David B, Guo, Mengye, Bůžková, Petra, Miller, Tracie L, Post, Wendy S, Stein, James H, Currier, Judith S, Kronmal, Richard A, Freiberg, Matthew S, Bennett, Siiri N, Shikuma, Cecilia M, Anastos, Kathryn, Li, Yanjie, Tracy, Russell P, Hodis, Howard N, Delaney, Joseph A, and Kaplan, Robert C

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Cardiovascular, Prevention, Atherosclerosis, Heart Disease, HIV/AIDS, Aging, Infection, Good Health and Well Being, Adolescent, Adult, Age Factors, Aged, Anti-HIV Agents, Carotid Artery, Common, Carotid Intima-Media Thickness, Child, Cohort Studies, Female, HIV Infections, Humans, Male, Middle Aged, Risk Factors, Ultrasonography, Young Adult, HIV infection, carotid artery intima-media thickness, aging, cardiovascular disease risk factors, biomarker, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundAge and human immunodeficiency virus (HIV) treatment may affect the association of HIV infection with atherosclerosis.MethodsWe used identical carotid artery B-mode ultrasonographic methods in 5 cohorts participating in the National Heart, Lung, and Blood Institute HIV-CVD Collaborative to measure intima-media thickness of the right far wall of the common carotid artery (CCA-IMT) and carotid artery bifurcation (BIF-IMT) between 2010 and 2013. Participants aged 6-75 years were either HIV infected or uninfected. Linear regression assessed associations of CCA-IMT and BIF-IMT with HIV infection and cardiovascular disease risk factors, within age and HIV treatment groups. Adjustment variables included sex, race/ethnicity, smoking, height, weight, and use of antihypertensive and lipid-lowering drugs.ResultsWe studied 867 HIV-infected and 338 HIV-uninfected male and 696 HIV-infected and 246 HIV-uninfected female participants. Among both middle-aged (30-49 years) and older adults (50-75 years), HIV-infected participants had CCA-IMT and BIF-IMT values that were similar to or lower than those in HIV-uninfected participants. In contrast, among those aged 6-29 years, HIV infection was associated with higher CCA-IMT and BIF-IMT values. Among HIV-infected participants, associations of higher systolic blood pressure and lower high-density lipoprotein cholesterol with Carotid artery intima-media thickness strengthened with age.ConclusionsThe effects of HIV on carotid artery structure may differ across the lifespan, with traditional determinants of cardiovascular disease burden playing a larger role and HIV playing a lesser role in older adults than in young adults and children.

Published
2016

5. Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges

Author

Agrawal, Arpana, Freedman, Neal D, Cheng, Yu-Ching, Lin, Peng, Shaffer, John R, Sun, Qi, Taylor, Kira, Yaspan, Brian, Cole, John W, Cornelis, Marilyn C, DeSensi, Rebecca S, Fitzpatrick, Annette, Heiss, Gerardo, Kang, Jae H, O’Connell, Jeffrey, Bennett, Siiri, Bookman, Ebony, Bucholz, Kathleen K, Caporaso, Neil, Crout, Richard, Dick, Danielle M, Edenberg, Howard J, Goate, Alison, Hesselbrock, Victor, Kittner, Steven, Kramer, John, Nurnberger, John I, Jr, Qi, Lu, Rice, John P, Schuckit, Marc, van Dam, Rob M, Boerwinkle, Eric, Hu, Frank, Levy, Steven, Marazita, Mary, Mitchell, Braxton D, Pasquale, Louis R, and Bierut, Laura J

Published
2012
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7. CHRNB3 is more strongly associated with Fagerström Test for Cigarette Dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results

Author

Rice, John P., Hartz, Sarah M., Agrawal, Arpana, Almasy, Laura, Bennett, Siiri, Breslau, Naomi, Bucholz, Kathleen K., Doheny, Kimberly F., Edenberg, Howard J., Goate, Alison M., Hesselbrock, Victor, Howells, William B., Johnson, Eric O., Kramer, John, Krueger, Robert F., Kuperman, Samuel, Laurie, Cathy, Manolio, Teri A., Neuman, Rosalind J., Nurnberger, John I., Porjesz, Bernice, Pugh, Elizabeth, Ramos, Erin M., Saccone, Nancy, Saccone, Scott, Schuckit, Marc, and Bierut, Laura J.

Published
2012
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8. Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers

Author

Hartz, Sarah M., Short, Susan E., Saccone, Nancy L., Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah H., Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Gubjartsson, Daniel, Hansel, Nadia N., Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikäinen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Rosenberger, Albert, Scheet, Paul, Shaffer, John R., Teumer, Alexander, Thompson, John R., Vink, Jacqueline M., Vogelzangs, Nicole, Wenzlaff, Angela S., Wheeler, William, Xiao, Xiangjun, Yang, Bao-Zhu, Aggen, Steven H., Balmforth, Anthony J., Baumeister, Sebastian E., Beaty, Terri, Bennett, Siiri, Bergen, Andrew W., Boyd, Heather A., Broms, Ulla, Campbell, Harry, Chatterjee, Nilanjan, Chen, Jingchun, Cheng, Yu-Ching, Cichon, Sven, Couper, David, Cucca, Francesco, Dick, Danielle M., Foroud, Tatiana, Furberg, Helena, Giegling, Ina, Gu, Fangyi, Hall, Alistair S., Hällfors, Jenni, Han, Shizhong, Hartmann, Annette M., Hayward, Caroline, Heikkilä, Kauko, Hewitt, John K., Hottenga, Jouke Jan, Jensen, Majken K., Jousilahti, Pekka, Kaakinen, Marika, Kittner, Steven J., Konte, Bettina, Korhonen, Tellervo, Landi, Maria-Teresa, Laatikainen, Tiina, Leppert, Mark, Levy, Steven M., Mathias, Rasika A., McNeil, Daniel W., Medland, Sarah E., Montgomery, Grant W., Muley, Thomas, Murray, Tanda, Nauck, Matthias, North, Kari, Pergadia, Michele, Polasek, Ozren, Ramos, Erin M., Ripatti, Samuli, Risch, Angela, Ruczinski, Ingo, Rudan, Igor, Salomaa, Veikko, Schlessinger, David, Styrkársdóttir, Unnur, Terracciano, Antonio, Uda, Manuela, Willemsen, Gonneke, Wu, Xifeng, Abecasis, Goncalo, Barnes, Kathleen, Bickeböller, Heike, Boerwinkle, Eric, Boomsma, Dorret I., Caporaso, Neil, Duan, Jubao, Edenberg, Howard J., Francks, Clyde, Gejman, Pablo V., Gelernter, Joel, Grabe, Hans Jörgen, Hops, Hyman, Jarvelin, Marjo-Riitta, Viikari, Jorma, Kähönen, Mika, Kendler, Kenneth S., Lehtimäki, Terho, Levinson, Douglas F., Marazita, Mary L., Marchini, Jonathan, Melbye, Mads, Mitchell, Braxton D., Murray, Jeffrey C., Nöthen, Markus M., Penninx, Brenda W., Raitakari, Olli, Rietschel, Marcella, Rujescu, Dan, Samani, Nilesh J., Sanders, Alan R., Schwartz, Ann G., Shete, Sanjay, Shi, Jianxin, Spitz, Margaret, Stefansson, Kari, Swan, Gary E., Thorgeirsson, Thorgeir, Völzke, Henry, Wei, Qingyi, Wichmann, H.-Erich, Amos, Christopher I., Breslau, Naomi, Cannon, Dale S., Ehringer, Marissa, Grucza, Richard, Hatsukami, Dorothy, Heath, Andrew, Johnson, Eric O., Kaprio, Jaakko, Madden, Pamela, Martin, Nicholas G., Stevens, Victoria L., Stitzel, Jerry A., Weiss, Robert B., Kraft, Peter, and Bierut, Laura J.

Published
2012
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9. Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis

Author

Marini, Sandro, Crawford, Katherine, Morotti, Andrea, Lee, Myung J, Pezzini, Alessandro, Moomaw, Charles J, Flaherty, Matthew L, Montaner, Joan, Roquer, Jaume, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano-Tarraga, Carolina, Slowik, Agnieszka, Jagiella, Jeremiasz M, Pera, Joanna, Urbanik, Andrzej, Pichler, Alexander, Hansen, Bjorn M, McCauley, Jacob L, Tirschwell, David L, Selim, Magdy, Brown, Devin L, Silliman, Scott L, Worrall, Bradford B, Meschia, James F, Kidwell, Chelsea S, Testai, Fernando D, Kittner, Steven J, Schmidt, Helena, Enzinger, Christian, Deary, Lan J, Rannikmae, Kristiina, Samarasekera, Neshika, Salman, Rustam Al-Shahi, Sudlow, Catherine L, Klijn, Catharina JM, van Nieuwenhuizen, Koen M, Fernandez-Cadenas, Israel, Delgado, Pilar, Nonving, Bo, Lindgren, Ame, Goldstein, Joshua N, Viswanathan, Anand, Greenberg, Steven M, Falcone, Guido J, Biffi, Alessandro, Langefeld, Carl D, Woo, Daniel, Rosand, Jonathan, Anderson, Christopher D, Smoller, Sylvia, Sorkin, John, Wang, Xingwu, Pikula, Aleksandra, Wolf, Philip, Debette, Stephanie, Seshadri, Sudha, de Bakker, Paul, Chasman, Daniel, Rexrode, Kathryn, Chen, Ida, Rotter, Jerome, Luke, May, Sale, Michelle, Lee, Tsong-Hai, Chang, Ku-Chou, Elkind, Mitchell, Goldstein, Larry, James, Michael Luke, Breteler, Monique, O'Donnell, Chris, Leys, Didier, Carty, Cara, Kidwell, Chelsea, Olesen, Jes, Sharma, Pankaj, Rich, Stephen, Tatlisumak, Turgot, Happola, Olli, Bijlenga, Philippe, Soriano, Carolina, Giralt, Eva, Cotlarcius, Loana, Hardy, John, Korostynski, Michal, Boncoraglio, Giorgio, Ballabio, Elena, Parati, Eugenio, Mateusz, Adamski, Dziedzic, Tomasz, Jagiella, Jeremiasz, Gasowski, Jerzy, Wnuk, Marcin, Olszanecki, Rafaf, Juchniewicz, Karol Jozef, Levi, Christopher, Nyquist, Paul, Cendes, Iscia, Cabral, Norberto, Franca, Paulo, Goncalves, Anderson, Keller, Lina, Crisby, Milita, Kostulas, Konstantinos, Lennnnens, Robin, Ahmadi, Kourosh, Opherk, Christian, Duering, Marco, Dichgans, Martin, Malik, Rainer, Gonik, Mariya, Staals, Julie, Melander, Olle, Burri, Philippe, Sadr-Nabavi, Ariane, Romero, Javier, Anderson, Chris, Falcone, Guido, Brouwers, Bart, Rost, Natalia, Du, Rose, Kourkoulis, Christina, Battey, Thomas, Lubitz, Steven, Mueller-Myhsok, Bertram, Meschia, James, Brott, Thomas, Pare, Guillaume, Schmidt, Reinhold, Seiler, Stephan, Blanton, Susan, Yamada, Yoshiji, Bersano, Anna, Rundek, Tatiana, Sacco, Ralph, Chan, Yu-Feng Yvonne, Gschwendtner, Andreas, Deng, Zhen, Barr, Taura, Gwinn, Katrina, Corriveau, Roderick, Singleton, Andrew, Waddy, Salina, Launer, Lenore, Chen, Christopher, Le, Kim En, Lee, Wei Ling, Tan, Eng King, Olugbodi, Akintomi, Rothwell, Peter, Schilling, Sabrina, Mok, Vincent, Lebedeva, Elena, Jem, Christina, Jood, Katarina, Olsson, Sandra, Kim, Helen, Lee, Chaeyoung, Kilarski, Laura, Markus, Hugh, Peycke, Jennifer, Bevan, Steve, Sheu, Wayne, Chiou, Hung Yi, Chern, Joseph, Giraldo, Elias, Taqi, Muhammad, Jain, Vivek, Lam, Olivia, Howard, George, Kittner, Steven, Mitchell, Braxton, Cole, John, O'Connell, Jeff, Milewicz, Dianna, Illoh, Kachikwu, Worrall, Bradford, Stine, Colin, Karaszewski, Bartosz, Werring, David, Sofat, Reecha, Smalley, June, Lindgren, Arne, Hansen, Bjorn, Norrving, Bo, Smith, Gustav, Martin, Juan Jose, Thijs, Vincent, Klijn, Karin, van't Hof, Femke, Algra, Ale, Macleod, Mary, Perry, Rodney, Arnett, Donna, Padovani, Alessandro, Cramer, Steve, Fisher, Marl, Saleheen, Danish, Broderick, Joseph, Kissela, Brett, Doney, Alex, Sudlow, Cathie, Silliman, Scott, McDonough, Caitrin, Walters, Matthew, Pedersen, Annie, Nakagawa, Kazuma, Chang, Christy, Dobbins, Mark, McArdle, Patrick, Chang, Yu-Ching, Brown, Robert, Brown, Devin, Holliday, Elizabeth, Kalaria, Raj, Maguire, Jane, Hunter, John, Attia, John, Farrall, Martin, Giese, Anne-Katrin, Fomage, Myriam, Majersik, Jennifer, Cushman, Maly, Keene, Keith, Bennett, Siiri, Tirschwell, David, Psaty, Bruce, Reiner, Alex, Longstreth, Will, Spence, David, Langefeld, Carl, Bushnell, Cheryl, Heitsch, Laura, Lee, Jin-Moo, Sheth, Kevin, Consortium, Int Genetics, Neurologian yksikkö, Department of Neurosciences, Clinicum, Doctoral Programme in Clinical Research, HUS Neurocenter, RS: Carim - B05 Cerebral small vessel disease, RS: CARIM - R3.03 - Cerebral small vessel disease, and Epidemiology

Subjects
Male, Race ethnicity, Hemorràgia cerebral, 3124 Neurology and psychiatry, 0302 clinical medicine, Risk Factors, WHITES, BLACKS, 030212 general & internal medicine, Biological sciences, Original Investigation, ALZHEIMER-DISEASE, African Americans, Aged, 80 and over, GENETIC-VARIATION, Hispanic or Latino, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Medical research, University hospital, 3. Good health, ETHNICITY, ALLELE, Research centre, Hypertension, lipids (amino acids, peptides, and proteins), Female, Apolipoprotein E, Core laboratory, Hispanic Americans, medicine.medical_specialty, COA REDUCTASE INHIBITORS, European Continental Ancestry Group, Clinical Neurology, Raça, APOE EPSILON-4, White People, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Apolipoproteins E, Political science, medicine, Journal Article, Online First, Humans, Genetic Predisposition to Disease, cardiovascular diseases, General hospital, Aged, Cerebral Hemorrhage, Research, LOBAR, 3112 Neurosciences, E GENOTYPE, United States, nervous system diseases, Black or African American, Cognitive epidemiology, Family medicine, Case-Control Studies, Neurology (clinical), 030217 neurology & neurosurgery
Abstract

Key Points Question Is history of hypertension and apolipoprotein E (APOE) associated with intracerebral hemorrhage risk in participants stratified by self-reported race/ethnicity? Findings In this case-control study of 13 124 adults, having a copy of APOE ε4 alleles increased the risk for lobar intracerebral hemorrhage only in white individuals, but after propensity score matching for hypertension burden, Hispanic individuals showed the same risk of APOE ε4. Meaning APOE ε4 appears to be confirmed as a risk factor for lobar intracerebral hemorrhage in nonwhite populations but is masked by differential hypertension burden in Hispanic individuals; further studies are needed to explore the interactions between APOE alleles and environmental exposures., Importance Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ε4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. Main Outcomes and Measures Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. Results In total, 13 124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ε2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P, This case-control study examines whether the risk for intracerebral hemorrhage presented by apolipoprotein E ε4 and ε2 alleles varies by race/ethnicity.

Published
2019

10. Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Author

Pulit, Sara L., Weng, Lu-Chen, McArdle, Patrick F, Trinquart, Ludovic, Choi, Seung Hoan, Mitchell, Braxton D., Rosand, Jonathan, de Bakker, Paul I W, Benjamin, Emelia J, Ellinor, Patrick T, Kittner, Steven J, Lubitz, Steven A, Anderson, Christopher D, Christophersen, Ingrid E., Rienstra, Michiel, Roselli, Carolina, Yin, Xiaoyan, Geelhoed, Bastiaan, Barnard, John, Lin, Honghuang, Arking, Dan E., Smith, Albert V., Albert, Christine M., Chaffin, Mark, Tucker, Nathan R., Li, Molong, Klarin, Derek, Bihlmeyer, Nathan A, Low, Siew-Kee, Weeke, Peter E., Müller-Nurasyid, Martina, Smith, J. Gustav, Brody, Jennifer A., Niemeijer, Maartje N., Dörr, Marcus, Trompet, Stella, Huffman, Jennifer, Gustafsson, Stefan, Schurmann, Claudia, Kleber, Marcus E., Lyytikäinen, Leo-Pekka, Seppälä, Ilkka, Malik, Rainer, Horimoto, Andrea R. V. R., Perez, Marco, Sinisalo, Juha, Aeschbacher, Stefanie, Thériault, Sébastien, Yao, Jie, Radmanesh, Farid, Weiss, Stefan, Teumer, Alexander, Clauss, Sebastian, Deo, Rajat, Rader, Daniel J., Shah, Svati, Siland, Joylene E., Kubo, Michiaki, Smith, Jonathan D., Van Wagoner, David R., Bis, Joshua C., Perz, Siegfried, Psaty, Bruce M., Ridker, Paul M., Magnani, Jared W., Harris, Tamara B., Launer, Lenore J., Shoemaker, M. Benjamin, Padmanabhan, Sandosh, Haessler, Jeffrey, Bartz, Traci M., Waldenberger, Melanie, Lichtner, Peter, Arendt, Marina, Krieger, Jose E., Kähönen, Mika, Risch, Lorenz, Mansur, Alfredo J., Peters, Annette, Smith, Blair H., Lind, Lars, Scott, Stuart A., Lu, Yingchang, Bottinger, Erwin B., Hernesniemi, Jussi, Lindgren, Cecilia M., Wong, Jorge A, Huang, Jie, Eskola, Markku, Morris, Andrew P., Ford, Ian, Reiner, Alex P., Delgado, Graciela, Chen, Lin Y., Chen, Yii-Der Ida, Sandhu, Roopinder K., Li, Man, Boerwinkle, Eric, Eisele, Lewin, Lannfelt, Lars, Rost, Natalia, Orho-Melander, arju, Hamsten, Anders, Heeringa, Jan, Denny, Joshua C., Kriebel, Jennifer, Darbar, Dawood, Newton-Cheh, Christopher, Shaffer, Christian, Macfarlane, Peter W., Heilmann, Stefanie, Almgren, Peter, Huang, Paul L., Sotoodehnia, Nona, Soliman, Elsayed Z., Uitterlinden, Andre G., Hofman, Albert, Franco, Oscar H., Völker, Uwe, Jöckel, Karl-Heinz, Sinner, Moritz F., Lin, Henry J., Guo, Xiuqing, Dichgans, Martin, Ingelsson, Erik, Kooperberg, Charles, Melander, Olle, Loos, Ruth J. F., Laurikka, Jari, Conen, David, Harst, Pim van der, Lokki, Marja-Liisa, Kathiresan, Sekar, Pereira, Alexandre, Jukema, J. Wouter, Hayward, Caroline, Rotter, Jerome I., März, Winfried, Lehtimäki, Terho, Stricker, Bruno H., Chung, Mina K., Felix, Stephan B., Gudnason, Vilmundur, Alonso, Alvaro, Roden, Dan M., Sun, Albert, Anderson, Christopher D., Kääb, Stefan, Hopewell, Jemma C., Debette, Stephanie, Chauhan, Ganesh, Yang, Qiong, Worrall, Bradford B., Paré, Guillaume, Kamatani, Yoichiro, Hagemeijer, Yanick P., Verweij, Niek, Taylor, Kent D., Campbell, Archie, Magnusson, Patrik K., Porteous, David, Hocking, Lynne J., Vlachopoulou, Efthymia, Pedersen, Nancy L., Nikus, Kjell, Chasman, Daniel I., Heckbert, Susan R., Benjamin, Emelia J., Tanaka, Toshihiro, Lunetta, Kathryn L., Lubitz, Steven A., Ellinor, Patrick T., Smoller, Sylvia, Sorkin, John, Wang, Xingwu, Selim, Magdy, Pikula, Aleksandra, Wolf, Philip, Seshadri, Sudha, Bakker, Paul de, Chasman, Daniel, Rexrode, Kathryn, Chen, Ida, Rotter, Jerome, Luke, May, Sale, Michelle, Lee, Tsong-Hai, Chang, Ku-Chou, Elkind, Mitchell, Goldstein, Larry, James, Michael Luke, Breteler, Monique, O’Donnell, Chris, Leys, Didier, Carty, Cara, Kidwell, Chelsea, Olesen, Jes, Sharma, Pankaj, Rich, Stephen, Tatlisumak, Turgot, Happola, Olli, Bijlenga, Philippe, Soriano, Carolina, Giralt, Eva, Roquer, Jaume, Jimenez-Conde, Jordi, Cotlarcius, Ioana, Hardy, John, Korostynski, Michal, Boncoraglio, Giorgio, Ballabio, Elena, Parati, Eugenio, Mateusz, Adamski, Urbanik, Andrzej, Dziedzic, Tomasz, Jagiella, Jeremiasz, Gasowski, Jerzy, Wnuk, Marcin, Olszanecki, Rafael, Pera, Joanna, Slowik, Agnieszka, Juchniewicz, Karol Jozef, Levi, Christopher, Nyquist, Paul, Cendes, Iscia, Cabral, Norberto, Franca, Paulo, Goncalves, Anderson, Keller, Lina, Crisby, Milita, Kostulas, Konstantinos, Lemmens, Robin, Ahmadi, Kourosh, Opherk, Christian, Duering, Marco, Gonik, Mariya, Staals, Julie, Burri, Philippe, Sadr-Nabavi, Ariane, Romero, Javier, Biffi, Alessandro, Anderson, Chris, Falcone, Guido, Brouwers, Bart, Du, Rose, Kourkoulis, Christina, Battey, Thomas, Lubitz, Steven, Mueller-Myhsok, Bertram, Meschia, James, Brott, Thomas, Pare, Guillaume, Pichler, Alexander, Enzinger, Christian, Schmidt, Helena, Schmidt, Reinhold, Seiler, Stephan, Blanton, Susan, Yamada, Yoshiji, Bersano, Anna, Rundek, Tatjana, Sacco, Ralph, Chan, Yu-Feng Yvonne, Gschwendtner, Andreas, Deng, Zhen, Barr, Taura, Gwinn, Katrina, Corriveau, Roderick, Singleton, Andrew, Waddy, Salina, Launer, Lenore, Chen, Christopher, Le, Kim En, Lee, Wei Ling, Tan, Eng King, Olugbodi, Akintomi, Rothwell, Peter, Schilling, Sabrina, Mok, Vincent, Lebedeva, Elena, Jern, Christina, Jood, Katarina, Olsson, Sandra, Kim, Helen, Lee, Chaeyoung, Kilarski, Laura, Markus, Hugh, Peycke, Jennifer, Bevan, Steve, Sheu, Wayne, Chiou, Hung Yi, Chern, Joseph, Giraldo, Elias, Taqi, Muhammad, Jain, Vivek, Lam, Olivia, Howard, George, Woo, Daniel, Kittner, Steven, Mitchell, Braxton, Cole, John, O’Connell, Jeff, Milewicz, Dianna, Illoh, Kachikwu, Worrall, Bradford, Stine, Colin, Karaszewski, Bartosz, Werring, David, Sofat, Reecha, Smalley, June, Lindgren, Arne, Hansen, Bjorn, Norrving, Bo, Smith, Gustav, Martin, Juan Jose, Thijs, Vincent, Klijn, Karin, van’t Hof, Femke, Algra, Ale, Macleod, Mary, Perry, Rodney, Arnett, Donna, Pezzini, Alessandro, Padovani, Alessandro, Cramer, Steve, Fisher, Mark, Saleheen, Danish, Broderick, Joseph, Kissela, Brett, Doney, Alex, Cathie, Sudlow, Rannikmae, Kristiina, Silliman, Scott, McDonough, Caitrin, Walters, Matthew, Pedersen, Annie, Nakagawa, Kazuma, Chang, Christy, Dobbins, Mark, McArdle, Patrick, Chang, Yu-Ching, Brown, Robert, Brown, Devin, Holliday, Elizabeth, Kalaria, Raj, Maguire, Jane, John, Attia, Farrall, Martin, Giese, Anne-Katrin, Fornage, Myriam, Majersik, Jennifer, Cushman, Mary, Keene, Keith, Bennett, Siiri, Tirschwell, David, Psaty, Bruce, Reiner, Alex, Longstreth, Will, Spence, David, Montaner, Joan, Fernandez-Cadenas, Israel, Langefeld, Carl, Bushnell, Cheryl, Heitsch, Laura, Lee, Jin-Moo, Sheth, Kevin, Cardiovascular Centre (CVC), Department of Medicine, Clinicum, Transplantation Laboratory, Medicum, Neurologian yksikkö, Department of Neurosciences, University of Helsinki, Doctoral Programme in Clinical Research, HUS Neurocenter, Epidemiology, Internal Medicine, Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, and MUMC+: MA Med Staf Spec Neurologie (9)

Subjects
Medizin, 030204 cardiovascular system & hematology, VARIANTS, 3124 Neurology and psychiatry, 0302 clinical medicine, Epidemiology, Genotype, EPIDEMIOLOGY, Stroke, Genetics (clinical), 0303 health sciences, Aspirin, Atrial fibrillation, ASSOCIATION, 3. Good health, LIFETIME RISK, ISCHEMIC-STROKE, Cardiology, Biomarker (medicine), Medical genetics, BURDEN, Medical Genetics, Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Clinical Neurology, Single-nucleotide polymorphism, Article, 03 medical and health sciences, Internal medicine, Genetic predisposition, medicine, SNP, cardiovascular diseases, Genotyping, 030304 developmental biology, Genetic association, Medicinsk genetik, Science & Technology, business.industry, 3112 Neurosciences, Heritability, medicine.disease, PREVENTION, ASPIRIN, Neurology (clinical), Neurosciences & Neurology, business, 030217 neurology & neurosurgery, CAUSATIVE CLASSIFICATION
Abstract

ObjectiveWe sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk.MethodsWe evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors.ResultsWe observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 × 10−4 in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 × 10−48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07, p = 0.004), but no other primary stroke subtypes (all p > 0.1).ConclusionsGenetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.

Published
2018

12. Postoperative infections traced to contamination of an intravenous anesthetic, propofol

Author

Bennett, Siiri N., McNeil, Michael M., Bland, Lee A., Arduino, Matthew J., Villarino, M. Elsa, Perrotta, Dennis M., Burwen, Dale R., Welbel, Sharon F., Pegues, David A., Stroud, Leonardo, Zeitz, Paul S., and Jarvis, William R.

Subjects
Anesthesia -- Complications, Infection -- Risk factors, Surgery -- Complications
Abstract

Propofol and other lipid-based anesthetics which accomodate rapid bacteria growth may easily become contaminated and cause serious complications in surgical patients. Researchers reviewed the medical records of 49 patients who developed infections or acute fever following surgery during an infection outbreak at one of seven hospitals. Researchers compared these records to those of uninfected surgical patients and investigated surgical procedures and equipment. Infections were associated with the use of propofol, and at some hospitals, exposure to certain anesthesia personnel. Anesthesia personnel were often negligent of sterile technique: they reused containers and syringes, failed to wear gloves, and did not disinfect container stoppers. Strict sterile technique should be observed by anesthesia personnel to prevent infection.

Published
1995

15. C. trachomatis and N. gonorrhoeae surveillance in New Zealand: comparison of laboratory and clinic data

Author

McNicholas, Anne M., Turley, Maria L., and Bennett, Siiri N.

Subjects
New Zealand -- Health aspects, Chlamydia infections -- Research, Gonorrhea -- Research, Health
Abstract

Objectives: To determine the extent to which clinic-based sexually transmitted infection (STI) surveillance under-represents the number of laboratory-confirmed cases of Chlamydia trachomatis and Neisseria gonorrhoeae in the Waikato and Bay of Plenty regions of New Zealand; and to estimate incidence rates for these two infections. Methods: Data on C. trachomatis and N. gonorrhoeae were collected from diagnostic laboratories in the study regions for the year 2000, and compared with routine clinic-based STI surveillance data. Results: Most laboratory-confirmed C. trachomatis (65.5%) and N. gonorrhoeae (55.7%) infections were diagnosed by healthcare providers outside the clinic-based STI surveillance system. The estimated incidence rate for C. trachomatis was 501 per 100,000, and 50 per 100,000 for N. gonorrhoeae. Conclusions and Implications: Laboratory surveillance of C. trachomatis and N. gonorrhoeae provides a more complete picture of disease burden. Given the high infection rates reported, developing a national strategy for the management of STIs should be a public health priority in New Zealand.

Published
2001

16. CHRNB3 is more strongly associated with FTCD-based nicotine dependence than cigarettes per day: phenotype definition changes GWAS results

Author

Rice, John P., Hartz, Sarah, Agrawal, Arpana, Almasy, Laura, Bennett, Siiri, Breslau, Naomi, Bucholz, Kathleen K., Doheny, Kimberly F., Edenberg, Howard J., Goate, Alison M., Hesselbrock, Victor, Howells, William B., Johnson, Eric O., Kramer, John, Krueger, Robert F., Kuperman, Samuel, Laurie, Cathy, Manolio, Teri A., Neuman, Rosalind J., Nurnberger, John I., Porjesz, Bernice, Pugh, Elizabeth, Ramos, Erin M., Saccone, Nancy, Saccone, Scott, Schuckit, Marc, and Bierut, Laura J.

Subjects
Adult, Male, Genotype, Tobacco Products, Tobacco Use Disorder, Middle Aged, Receptors, Nicotinic, Polymorphism, Single Nucleotide, Article, Phenotype, Genetic Loci, Case-Control Studies, Humans, Female, Aged, Chromosomes, Human, Pair 8, Genome-Wide Association Study
Abstract

Nicotine dependence is a highly heritable disorder associated with severe medical morbidity and mortality. Recent meta-analyses have found novel genetic loci associated with cigarettes per day (CPD), a proxy for nicotine dependence. The aim of this paper is to evaluate the importance of phenotype definition (i.e., CPD versus Fagerström test for cigarette dependence (FTCD) score as a measure of nicotine dependence) on genome-wide association studies of nicotine dependence.Genome-wide association study.Community sample.A total of 3365 subjects who had smoked at least one cigarette were selected from the Study of Addiction: Genetics and Environment (SAGE). Of the participants, 2267 were European Americans, 999 were African Americans.Nicotine dependence defined by FTCD score ≥4, CPD.The genetic locus most strongly associated with nicotine dependence was rs1451240 on chromosome 8 in the region of CHRNB3 [odds ratio (OR) = 0.65, P = 2.4 × 10(-8) ]. This association was further strengthened in a meta-analysis with a previously published data set (combined P = 6.7 × 10(-16) , total n = 4200). When CPD was used as an alternate phenotype, the association no longer reached genome-wide significance (β = -0.08, P = 0.0004).Daily cigarette consumption and the Fagerstrom Test for Cigarette Dependence show different associations with polymorphisms in genetic loci.

Published
2012

17. Detectable clonal mosaicism from birth to old age and its relationship to cancer

Author

Laurie, Cathy C., Laurie, Cecelia A., Rice, Kenneth, Doheny, Kimberly F., Zelnick, Leila R., McHugh, Caitlin P., Ling, Hua, Hetrick, Kurt N., Pugh, Elizabeth W., Amos, Chris, Wei, Qingyi, Wang, Li E., Lee, Jeffrey E., Barnes, Kathleen C., Hansel, Nadia N., Mathias, Rasika, Daley, Denise, Beaty, Terri H., Scott, Alan F., Ruczinski, Ingo, Scharpf, Rob B., Bierut, Laura J., Hartz, Sarah M., Landi, Maria Teresa, Freedman, Neal D., Goldin, Lynn R., Ginsburg, David, Li, Jun, Desch, Karl C., Strom, Sara S., Blot, William J., Signorello, Lisa B., Ingles, Sue A., Chanock, Stephen J., Berndt, Sonja I., Le Marchand, Loic, Henderson, Brian E., Monroe, Kristine R., Heit, John A., De Andrade, Mariza, Armasu, Sebastian M., Regnier, Cynthia, Lowe, William L., Hayes, M. Geoffrey, Marazita, Mary L., Feingold, Eleanor, Murray, Jeffrey C., Melbye, Mads, Feenstra, Bjarke, Kang, Jae H., Wiggs, Janey L., Jarvik, Gail P., McDavid, Andrew N., Seshan, Venkatraman E., Mirel, Daniel B., Crenshaw, Andrew, Sharopova, Nataliya, Wise, Anastasia, Shen, Jess, Crosslin, David R., Levine, David M., Zheng, Xiuwen, Udren, Jenna I., Bennett, Siiri, Nelson, Sarah C., Gogarten, Stephanie M., Conomos, Matthew P., Heagerty, Patrick, Manolio, Teri, Pasquale, Louis R., Haiman, Christopher A., Caporaso, Neil, Weir, Bruce S., Laurie, Cathy C., Laurie, Cecelia A., Rice, Kenneth, Doheny, Kimberly F., Zelnick, Leila R., McHugh, Caitlin P., Ling, Hua, Hetrick, Kurt N., Pugh, Elizabeth W., Amos, Chris, Wei, Qingyi, Wang, Li E., Lee, Jeffrey E., Barnes, Kathleen C., Hansel, Nadia N., Mathias, Rasika, Daley, Denise, Beaty, Terri H., Scott, Alan F., Ruczinski, Ingo, Scharpf, Rob B., Bierut, Laura J., Hartz, Sarah M., Landi, Maria Teresa, Freedman, Neal D., Goldin, Lynn R., Ginsburg, David, Li, Jun, Desch, Karl C., Strom, Sara S., Blot, William J., Signorello, Lisa B., Ingles, Sue A., Chanock, Stephen J., Berndt, Sonja I., Le Marchand, Loic, Henderson, Brian E., Monroe, Kristine R., Heit, John A., De Andrade, Mariza, Armasu, Sebastian M., Regnier, Cynthia, Lowe, William L., Hayes, M. Geoffrey, Marazita, Mary L., Feingold, Eleanor, Murray, Jeffrey C., Melbye, Mads, Feenstra, Bjarke, Kang, Jae H., Wiggs, Janey L., Jarvik, Gail P., McDavid, Andrew N., Seshan, Venkatraman E., Mirel, Daniel B., Crenshaw, Andrew, Sharopova, Nataliya, Wise, Anastasia, Shen, Jess, Crosslin, David R., Levine, David M., Zheng, Xiuwen, Udren, Jenna I., Bennett, Siiri, Nelson, Sarah C., Gogarten, Stephanie M., Conomos, Matthew P., Heagerty, Patrick, Manolio, Teri, Pasquale, Louis R., Haiman, Christopher A., Caporaso, Neil, and Weir, Bruce S.

Abstract

We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively high frequency of cells with the same abnormal karyotype (>5-10%; presumably of clonal origin) in the presence of normal cells. The frequency of detectable clonal mosaicism in peripheral blood is low (<0.5%) from birth until 50 years of age, after which it rapidly rises to 2-3% in the elderly. Many of the mosaic anomalies are characteristic of those found in hematological cancers and identify common deleted regions with genes previously associated with these cancers. Although only 3% of subjects with detectable clonal mosaicism had any record of hematological cancer before DNA sampling, those without a previous diagnosis have an estimated tenfold higher risk of a subsequent hematological cancer (95% confidence interval = 6-18).

Published
2012

18. Detectable clonal mosaicism from birth to old age and its relationship to cancer

Author

Laurie, Cathy C, primary, Laurie, Cecelia A, additional, Rice, Kenneth, additional, Doheny, Kimberly F, additional, Zelnick, Leila R, additional, McHugh, Caitlin P, additional, Ling, Hua, additional, Hetrick, Kurt N, additional, Pugh, Elizabeth W, additional, Amos, Chris, additional, Wei, Qingyi, additional, Wang, Li-e, additional, Lee, Jeffrey E, additional, Barnes, Kathleen C, additional, Hansel, Nadia N, additional, Mathias, Rasika, additional, Daley, Denise, additional, Beaty, Terri H, additional, Scott, Alan F, additional, Ruczinski, Ingo, additional, Scharpf, Rob B, additional, Bierut, Laura J, additional, Hartz, Sarah M, additional, Landi, Maria Teresa, additional, Freedman, Neal D, additional, Goldin, Lynn R, additional, Ginsburg, David, additional, Li, Jun, additional, Desch, Karl C, additional, Strom, Sara S, additional, Blot, William J, additional, Signorello, Lisa B, additional, Ingles, Sue A, additional, Chanock, Stephen J, additional, Berndt, Sonja I, additional, Le Marchand, Loic, additional, Henderson, Brian E, additional, Monroe, Kristine R, additional, Heit, John A, additional, de Andrade, Mariza, additional, Armasu, Sebastian M, additional, Regnier, Cynthia, additional, Lowe, William L, additional, Hayes, M Geoffrey, additional, Marazita, Mary L, additional, Feingold, Eleanor, additional, Murray, Jeffrey C, additional, Melbye, Mads, additional, Feenstra, Bjarke, additional, Kang, Jae H, additional, Wiggs, Janey L, additional, Jarvik, Gail P, additional, McDavid, Andrew N, additional, Seshan, Venkatraman E, additional, Mirel, Daniel B, additional, Crenshaw, Andrew, additional, Sharopova, Nataliya, additional, Wise, Anastasia, additional, Shen, Jess, additional, Crosslin, David R, additional, Levine, David M, additional, Zheng, Xiuwen, additional, Udren, Jenna I, additional, Bennett, Siiri, additional, Nelson, Sarah C, additional, Gogarten, Stephanie M, additional, Conomos, Matthew P, additional, Heagerty, Patrick, additional, Manolio, Teri, additional, Pasquale, Louis R, additional, Haiman, Christopher A, additional, Caporaso, Neil, additional, and Weir, Bruce S, additional

Published
2012
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19. Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

Author

Cornelis, Marilyn C., primary, Monda, Keri L., additional, Yu, Kai, additional, Paynter, Nina, additional, Azzato, Elizabeth M., additional, Bennett, Siiri N., additional, Berndt, Sonja I., additional, Boerwinkle, Eric, additional, Chanock, Stephen, additional, Chatterjee, Nilanjan, additional, Couper, David, additional, Curhan, Gary, additional, Heiss, Gerardo, additional, Hu, Frank B., additional, Hunter, David J., additional, Jacobs, Kevin, additional, Jensen, Majken K., additional, Kraft, Peter, additional, Landi, Maria Teresa, additional, Nettleton, Jennifer A., additional, Purdue, Mark P., additional, Rajaraman, Preetha, additional, Rimm, Eric B., additional, Rose, Lynda M., additional, Rothman, Nathaniel, additional, Silverman, Debra, additional, Stolzenberg-Solomon, Rachael, additional, Subar, Amy, additional, Yeager, Meredith, additional, Chasman, Daniel I., additional, van Dam, Rob M., additional, and Caporaso, Neil E., additional

Published
2011
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20. The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions

Author

Cornelis, Marilyn C., primary, Agrawal, Arpana, additional, Cole, John W., additional, Hansel, Nadia N., additional, Barnes, Kathleen C., additional, Beaty, Terri H., additional, Bennett, Siiri N., additional, Bierut, Laura J., additional, Boerwinkle, Eric, additional, Doheny, Kimberly F., additional, Feenstra, Bjarke, additional, Feingold, Eleanor, additional, Fornage, Myriam, additional, Haiman, Christopher A., additional, Harris, Emily L., additional, Hayes, M. Geoffrey, additional, Heit, John A., additional, Hu, Frank B., additional, Kang, Jae H., additional, Laurie, Cathy C., additional, Ling, Hua, additional, Manolio, Teri A., additional, Marazita, Mary L., additional, Mathias, Rasika A., additional, Mirel, Daniel B., additional, Paschall, Justin, additional, Pasquale, Louis R., additional, Pugh, Elizabeth W., additional, Rice, John P., additional, Udren, Jenna, additional, van Dam, Rob M., additional, Wang, Xiaojing, additional, Wiggs, Janey L., additional, Williams, Kayleen, additional, and Yu, Kai, additional

Published
2010
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21. Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience.

Author

Bennett, Siiri N., Caporaso, Neil, Fitzpatrick, Annette L., Agrawal, Arpana, Barnes, Kathleen, Boyd, Heather A., Cornelis, Marilyn C., Hansel, Nadia N., Heiss, Gerardo, Heit, John A., Kang, Jae Hee, Kittner, Steven J., Kraft, Peter, Lowe, William, Marazita, Mary L., Monroe, Kristine R., Pasquale, Louis R., Ramos, Erin M., van Dam, Rob M., and Udren, Jenna

Published
2011
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22. C. trachomatisand N. gonorrhoeaesurveillance in New Zealand: comparison of laboratory and clinic data

Author

McNicholas, Anne M., L.Turley, Maria, and Bennett, Siiri N.

Abstract

To determine the extent to which clinic‐based sexually transmitted infection (STI) surveillance under‐represents the number of laboratory‐confirmed cases of Chlamydia trachomatisand Neisseria gonorrhoeaein the Waikato and Bay of Plenty regions of New Zealand; and to estimate incidence rates for these two infections.

Published
2001
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23. Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

Author

van Dam, Rob M., Nettleton, Jennifer A., Couper, David, Landi, Maria Teresa, Silverman, Debra, Curhan, Gary, Cornelis, Marilyn C., Stolzenberg-Solomon, Rachael, Chanock, Stephen, Rajaraman, Preetha, Jacobs, Kevin, Heiss, Gerardo, Kraft, Peter, Berndt, Sonja I., Hunter, David J., Paynter, Nina, Yu, Kai, Caporaso, Neil E., Monda, Keri L., Rimm, Eric B., Azzato, Elizabeth M., Rothman, Nathaniel, Chatterjee, Nilanjan, Hu, Frank B., Boerwinkle, Eric, Jensen, Majken K., Yeager, Meredith, Purdue, Mark P., Bennett, Siiri N., Chasman, Daniel I., Subar, Amy, and Rose, Lynda M.

Subjects
respiratory system, 3. Good health
Abstract

We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10−19), near AHR, and 15q24 (P = 5.2×10−14), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.

24. Propofol and Postoperative Infections.

Author

Bennett, Siiri N. and Jarvis, William R.

Subjects
*LETTERS to the editor, *ASEPSIS & antisepsis
Abstract

A reply by Siiri N. Bennett and William R. Jarvis to letters to the editor about their article ¿Postoperative infections traced to contamination of an intravenous anesthetic, propofol,¿ in the July 20, 1995 issue is presented.

Published
1995
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25. Multiple COVID-19 Outbreaks Linked to a Wedding Reception in Rural Maine - August 7-September 14, 2020.

Author

Mahale P, Rothfuss C, Bly S, Kelley M, Bennett S, Huston SL, and Robinson S

Subjects
Adolescent, Adult, Aged, Betacoronavirus isolation & purification, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Contact Tracing, Coronavirus Infections diagnosis, Coronavirus Infections transmission, Female, Humans, Maine epidemiology, Male, Marriage, Middle Aged, Pandemics, Pneumonia, Viral transmission, SARS-CoV-2, Young Adult, Coronavirus Infections epidemiology, Disease Outbreaks, Pneumonia, Viral epidemiology, Prisons statistics & numerical data, Residential Facilities statistics & numerical data, Rural Population statistics & numerical data
Abstract

Large indoor gatherings pose a high risk for transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), and have the potential to be super-spreading events (1,2). Such events are associated with explosive growth, followed by sustained transmission (3). During August 7-September 14, 2020, the Maine Center for Disease Control and Prevention (MeCDC) investigated a COVID-19 outbreak linked to a wedding reception attended by 55 persons in a rural Maine town. In addition to the community outbreak, secondary and tertiary transmission led to outbreaks at a long-term care facility 100 miles away and at a correctional facility approximately 200 miles away. Overall, 177 COVID-19 cases were epidemiologically linked to the event, including seven hospitalizations and seven deaths (four in hospitalized persons). Investigation revealed noncompliance with CDC's recommended mitigation measures. To reduce transmission, persons should avoid large gatherings, practice physical distancing, wear masks, stay home when ill, and self-quarantine after exposure to a person with confirmed SARS-CoV-2 infection. Persons can work with local health officials to increase COVID-19 awareness and determine the best policies for organizing social events to prevent outbreaks in their communities., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.

Published
2020
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