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3. Evolving Practice and Outcomes in Grade 2 Glioma: Real-World Data from a Multi-Institutional Registry.

Author

Gately, Lucy, Drummond, Katharine, Dowling, Anthony, Bennett, Iwan, Freilich, Ronnie, Phillips, Claire, Ahern, Elizabeth, Campbell, David, Dumas, Megan, Campbell, Robert, Harrup, Rosemary, Kim, Grace Y., Reeves, Simone, Collins, Ian M., and Gibbs, Peter

Subjects
RISK assessment, BIOPSY, GLIOMAS, RADIOTHERAPY, RESEARCH funding, TUMOR grading, REPORTING of diseases, CANCER patients, DESCRIPTIVE statistics, RETROSPECTIVE studies, CANCER chemotherapy, KAPLAN-Meier estimator, MEDICAL records, ACQUISITION of data, PROGRESSION-free survival, TIME, OVERALL survival
Abstract

Simple Summary: This study explored the current practices in the real world for grade 2 glioma, an uncommon primary brain cancer. Leveraging the prospective BRAIN registry, this study demonstrates that whilst sequential radiotherapy and chemotherapy improve progression-free survival in high-risk grade 2 glioma, the majority of patients are observed following surgery. In high-risk patients who are observed, 61% remain progression-free at 12 months, with 10% being progression-free at 5 years. This clinically meaningful progression-free survival suggests that validated biomarkers beyond the usual definition of high-risk are required to better inform patient management. Factors contributing to decision-making are underway. Background: Grade-2 gliomas (G2-glioma) are uncommon. In 2016, RTOG9802 established the addition of chemotherapy after radiation (CRT) as a new standard of care for patients with high-risk G2-glioma, defined as subtotal resection or age ≥40 yrs. Here, we report current practices using real-world data. Methods: Patients diagnosed with G2-glioma from 1 January 2016 to 31 December 2022 were identified in BRAIN, a prospective clinical registry collecting data on patients with brain tumours. High- and low-risk were defined as per RTOG9802. Two time periods, January 2016–December 2019 (TP1) and January 2020–December 2022 (TP2), were defined. Survival was estimated using the Kaplan–Meier method. Results: 224 patients were identified. Overall, 38 (17%) were low-risk, with 35 (91%) observed without further treatment. A total of 186 (83%) were high-risk, with 96 (52%) observed, 63 (34%) receiving CRT, and 19 (10%) receiving radiation. Over time, CRT use increased (TP1 vs. TP2: 22% vs. 36%, p = 0.004), and the rate of biopsy (TP1 vs. TP2: 35% vs. 20%, p = 0.02) and radiotherapy alone (TP1 vs. TP2: 14% vs. 4%, p = 0.01) decreased. Median progression-free survival (PFS) was significantly longer in high-risk patients who received CRT (NR) over observation (39 months) (HR 0.49, p = 0.007). In high-risk patients who were observed, 59 (61%) were progression-free at 12 months and 10 (10%) at 5 years. OS data remains immature. Conclusion: Congruent with RTOG9802, real-world BRAIN data shows CRT is associated with improved PFS compared to observation in high-risk G2-glioma. Whilst CRT use has increased over time, observation after surgery remains the most common strategy, with some high-risk patients achieving clinically meaningful PFS. Validated biomarkers are urgently required to better inform patient management. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Serum microRNA is a biomarker for post-operative monitoring in glioma

Author

Morokoff, Andrew, Jones, Jordan, Nguyen, Hong, Ma, Chenkai, Lasocki, Arian, Gaillard, Frank, Bennett, Iwan, Luwor, Rod, Stylli, Stanley, Paradiso, Lucia, Koldej, Rachel, Paldor, Iddo, Molania, Ramyar, Speed, Terence P., Webb, Andrew, Infusini, Guiseppe, Li, Jason, Malpas, Charles, Kalincik, Tomas, Drummond, Katharine, Siegal, Tali, and Kaye, Andrew H.

Published
2020
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5. QLTI-04. LINKING DATA FROM A BRAIN CANCER CLINICAL REGISTRY (BRAIN) WITH THE STATE-BASED REGISTRY OF BIRTHS DEATHS MARRIAGES: IMPROVING THE QUALITY OF CLINICAL REGISTRY SURVIVAL DATA

Author

Smith, Samuel, primary, Drummond, Kate, additional, Dowling, Anthony, additional, Bennett, Iwan, additional, Freilich, Ronnie, additional, Phillips, Claire, additional, Ahern, Elizabeth, additional, Reeves, Simone, additional, Campbell, Robert, additional, Collins, Ian, additional, Johns, Julie, additional, Dumas, Megan, additional, Gibbs, Peter, additional, and Gately, Lucy, additional

Published
2023
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6. Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study

Author

Woodfield, Julie, primary, Hoeritzauer, Ingrid, additional, Jamjoom, Aimun A.B., additional, Jung, Josephine, additional, Lammy, Simon, additional, Pronin, Savva, additional, Hannan, Cathal J., additional, Watts, Anna, additional, Hughes, Laura, additional, Moon, Richard D.C., additional, Darwish, Stacey, additional, Roy, Holly, additional, Copley, Phillip C., additional, Poon, Michael T.C., additional, Thorpe, Paul, additional, Srikandarajah, Nisaharan, additional, Grahovac, Gordan, additional, Demetriades, Andreas K., additional, Eames, Niall, additional, Sell, Philip J., additional, Statham, Patrick F.X., additional, Abdelsadg, Mohamed, additional, Abulaila, Motaz MS, additional, Ahmed, Usman, additional, Ajmi, Qasim, additional, Al-Mahfoudh, Rafid, additional, Ali, Chadi, additional, Amarouche, Meriem, additional, Andalib, Amin, additional, Arora, Mohit, additional, Arora, Mukul, additional, Awan, Mariam, additional, Baig Mirza, Asfand, additional, Bateman, Antony, additional, Bennett, Iwan, additional, Bhatti, Imran, additional, Bodkin, Peter, additional, Bommireddy, Lalasa, additional, Bonanos, George, additional, Borg, Anouk, additional, Boukas, Alexandros, additional, Bourne, James, additional, Brennan, Rachael, additional, Brown, Jennifer, additional, Brown, Katie, additional, Burton, Oliver, additional, Busby, Christopher, additional, Chiverton, Neil, additional, Clark, Simon, additional, Copley, Phillip C, additional, Cudlip, Simon, additional, Cunningham, Yan, additional, Dardis, Ronan, additional, Davies, Benjamin, additional, Demetriades, Andreas K, additional, Deore, Saurabh, additional, Derham, Chris, additional, Dherijha, Muhammad, additional, Dobson, Gareth, additional, Duncan, James, additional, Durnford, Andrew, additional, Durst, Alexander ZE, additional, Dyson, Edward W, additional, Edlmann, Ellie, additional, Edwards-Bailey, Andrew, additional, Elserius, Anne, additional, Elson, Becca, additional, Fadelalla, Mohammed, additional, Fountain, Daniel M, additional, Gardner, Adrian, additional, Ghosh, Arnab, additional, Gill, James R, additional, Glasmacher, Stella A, additional, Gordon, Robin, additional, Grenfell, Rebecca, additional, Habeebullah, Awais, additional, Haliasos, Nikolaos, additional, Hammett, Tim, additional, Hannan, Cathal John, additional, Hill, Ciaran Scott, additional, Holmes, David, additional, Hossain-Ibrahim, Kismet, additional, Hussain, Muhammad, additional, Hussain, Shakir, additional, Ibrahim, Ramez, additional, Jamjoom, Aimun AB, additional, John, Bethan, additional, Joshi, Shabin, additional, Kennion, Oliver, additional, Khan, Muhammad, additional, Klejnotowska, Adriana, additional, Kumaria, Ashwin, additional, LaCava, Roberta, additional, Lawrence, Alistair, additional, Lea, Matthew, additional, Leung, Andraay HC, additional, Liew, Ignatius, additional, Luo, Weisang, additional, MacCormac, Oscar, additional, Manfield, James, additional, Mannion, Richard, additional, Merola, Joseph, additional, Mishra, Pranav, additional, Mohmoud, Khalid Abubaker, additional, Moon, Richard, additional, Morrison, Rory, additional, Murray, Odhran, additional, Nader-Sepahi, Ali, additional, Nnandi, Colin, additional, Pandit, Anand, additional, Patel, Nitin, additional, Philip, Anita, additional, Poon, Michael TC, additional, Prasad, Kuskoor Seethram Manjunath, additional, Pujara, Shyam, additional, Purushothaman, Balaji, additional, Rajwani, Kapil, additional, Rasul, Fahid Tariq, additional, Sadek, Ahmed-Ramadan, additional, Schramm, Moritz, additional, Scicluna, Gabrielle, additional, Sell, Philip J, additional, Shafafy, Roozbeh, additional, Sharma, Himanshu, additional, Sheikh, Asim, additional, Sivasubramaniam, Vinothan, additional, Sofela, Agbolahan, additional, Spink, George, additional, Statham, Patrick FX, additional, Stokes, Stuart, additional, Strachan, Euan, additional, Thakar, Chrishan, additional, Thanabalasundaram, Gopiga, additional, Ulbricht, Christian, additional, Whitcher, Alison, additional, White, David, additional, Whitehouse, Kathrin, additional, Wilby, Martin, additional, Woodfield, Julie, additional, and Zolnourian, Ardalan, additional

Published
2023
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10. 2305 Glioblastoma – inhibition of P2X7R as a potential therapeutic target for treatment of this aggressive cancer

Author

Monif, Mastura, primary, Kan, Liyen Katrina, additional, Drill, Matthew, additional, Galea, Emily, additional, Todaro, Marian, additional, Ali, Rashida, additional, Bennett, Iwan, additional, Powell, Kim, additional, Williams, David, additional, Hamilton, John, additional, Zhu, Hongjian, additional, McLean, Catriona, additional, Jones, Nigel C, additional, Hunn, Martin, additional, Drummond, Kate J, additional, and O’Brien, Terence J, additional

Published
2022
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11. Additional file 1 of Beyond standard data collection – the promise and potential of BRAIN (Brain tumour Registry Australia INnovation and translation registry)

Author

Gately, Lucy, Drummond, Katharine, Rosenthal, Mark, Harrup, Rosemary, Dowling, Anthony, Gogos, Andrew, Lwin, Zarnie, Collins, Ian, Campbell, David, Ahern, Elizabeth, Phillips, Claire, Gan, Hui K., Bennett, Iwan, Sieber, Oliver M., and Gibbs, Peter

Abstract

Additional file 1: Supplementary Table 1. Data points collected in BRAIN. Supplementary Figure 1. Schematic overview of BRAIN with surrounding tumour types representing predetermined modules.

Published
2022
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13. An ovine model of cerebral catheter venography for implantation of an endovascular neural interface

Author

Oxley, Thomas James, primary, Opie, Nicholas Lachlan, additional, Rind, Gil Simon, additional, Liyanage, Kishan, additional, John, Sam Emmanuel, additional, Ronayne, Stephen, additional, McDonald, Alan James, additional, Dornom, Anthony, additional, Lovell, Timothy John Haynes, additional, Mitchell, Peter John, additional, Bennett, Iwan, additional, Bauquier, Sebastien, additional, Warne, Leon Norris, additional, Steward, Chris, additional, Grayden, David Bruce, additional, Desmond, Patricia, additional, Davis, Stephen M., additional, O'Brien, Terence John, additional, and May, Clive N., additional

Published
2018
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15. Biomarkers of tumour vascularity in high grade glioma

Author

Bennett, Iwan and Bennett, Iwan

Abstract

Australia has one of the highest cancer incidences in the world, and while brain cancer is a relatively rare diagnosis, its impact on the Australian healthcare system is significant. Despite being responsible for only 1.4% of all cancer diagnoses, brain cancer has an overall impact of disease as measured by DALYs similar to much more prevalent malignancies such as melanoma and leukaemia. A young median age of diagnosis and poor 5-year survival both contribute to this. No other cancer group is responsible for a greater premature loss of life, with an average of 12 years lost per person. High grade gliomas, particularly glioblastoma multiforme, are by far the most common brain cancers, and remains incurable and highly malignant. Glioblastoma multiforme is one of the most vascular cancers found in humans, and the degree of this vascularity (as seen histologically) is known to correlate with brain tumour prognosis. More recently there has been renewed interest in tumour vascularity, with the emergence of the anti-angiogenic therapy as the newest modality of cancer treatment. Some of these agents are currently under trial in brain cancer patients in Australia. Despite its prognostic value and its potential utility perhaps as a surrogate endpoint in anti-angiogenic therapy, histopathological assessment of tumour vascularity has never been routinely used in clinical practice. This is due to its invasive nature of procurement, as well as documented concerns regarding sampling errors and inter-observer variability. These concerns would be potentially negated by the identification of appropriate biomarker of tumour vascularity. This thesis investigated candidate biomarkers of tumour vascularity in an effort to identify clinically useful tools to help in the management of high grade glioma patients. Biomarkers from each marker category were represented – molecular (serum vascular endothelial growth factor), cellular (circulating endothelial cells and their progenitors), and fu

Published
2016

18. Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

Author

Oxley, Thomas J, primary, Opie, Nicholas L, additional, John, Sam E, additional, Rind, Gil S, additional, Ronayne, Stephen M, additional, Wheeler, Tracey L, additional, Judy, Jack W, additional, McDonald, Alan J, additional, Dornom, Anthony, additional, Lovell, Timothy J H, additional, Steward, Christopher, additional, Garrett, David J, additional, Moffat, Bradford A, additional, Lui, Elaine H, additional, Yassi, Nawaf, additional, Campbell, Bruce C V, additional, Wong, Yan T, additional, Fox, Kate E, additional, Nurse, Ewan S, additional, Bennett, Iwan E, additional, Bauquier, Sébastien H, additional, Liyanage, Kishan A, additional, van der Nagel, Nicole R, additional, Perucca, Piero, additional, Ahnood, Arman, additional, Gill, Katherine P, additional, Yan, Bernard, additional, Churilov, Leonid, additional, French, Christopher R, additional, Desmond, Patricia M, additional, Horne, Malcolm K, additional, Kiers, Lynette, additional, Prawer, Steven, additional, Davis, Stephen M, additional, Burkitt, Anthony N, additional, Mitchell, Peter J, additional, Grayden, David B, additional, May, Clive N, additional, and O'Brien, Terence J, additional

Published
2016
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