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Your search keyword '"Bennett, D C"' showing total 239 results
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239 results on '"Bennett, D C"'

1. Endosomal sorting during melanogenesis

Author

Dennis, M. K., Mantegazza, A. R., Acosta-Ruiz, A., Delevoye, C., Hurbain, I., Romao, M., Hesketh, G. G., Seaman, M., Sviderskaya, E. V., Bennett, D. C., Galli, T., Luzio, J. P., Owen, D. J., Raposo, G., and Marks, M. S.

Published
2015

18. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence

Author

Sadaie, M., Salama, R., Carroll, T., Tomimatsu, K., Chandra, T., Young, A. R., Narita, M., Perez-Mancera, P. A., Bennett, D. C., Chong, H., and Kimura, Hiroshi

Subjects
Senescence, senescence, Heterochromatin, Histones/metabolism, Cell Line, Histones, Cell Aging/*genetics, Chromatin Assembly and Disassembly/*genetics, Heterochromatin/chemistry/*metabolism, Genetics, Lamin B1, Cells, Cultured, Cellular Senescence, Cell Nucleus, Regulation of gene expression, epigenetics, Lamin Type B, biology, Lamin Type B/genetics/*metabolism, Chromatin Assembly and Disassembly, Protein Structure, Tertiary, Chromatin, Cell biology, Histone, Gene Expression Regulation, Cell Nucleus/metabolism, embryonic structures, biology.protein, Nuclear lamina, Cell aging, Lamin, Protein Binding, Research Paper, Developmental Biology
Abstract

Senescence is a stress-responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin into senescence-associated heterochromatic foci (SAHFs). Studying a key component of the nuclear lamina lamin B1 (LMNB1), we report dynamic alterations in its genomic profile and their implications for SAHF formation and gene regulation during senescence. Genome-wide mapping reveals that LMNB1 is depleted during senescence, preferentially from the central regions of lamina-associated domains (LADs), which are enriched for Lys9 trimethylation on histone H3 (H3K9me3). LMNB1 knockdown facilitates the spatial relocalization of perinuclear H3K9me3-positive heterochromatin, thus promoting SAHF formation, which could be inhibited by ectopic LMNB1 expression. Furthermore, despite the global reduction in LMNB1 protein levels, LMNB1 binding increases during senescence in a small subset of gene-rich regions where H3K27me3 also increases and gene expression becomes repressed. These results suggest that LMNB1 may contribute to senescence in at least two ways due to its uneven genome-wide redistribution: first, through the spatial reorganization of chromatin and, second, through gene repression.

Published
2013
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23. dɔʏtʃ

Author

Böll, Heinrich and Bennett, D. C.

Published
1964

24. The Ocular Albinism Type 1 (Oa1) Protein, an intracellular G Protein-Coupled receptor, regulates melanosome transport in pigment cells

Author

Palmisano, I., Bagnato, Paola, Palmigiano, A., Innamorati, G., Rotondo, G., Altimare, D., Venturi, C., Sviderskaya, E. V., Piccirillo, R., Coppola, M., Marigo, V., Incerti, B., Ballabio, A., Surace, E. M., Tacchetti, Carlo, Bennett, D. C., Schiaffino, M. V., Palmisano, I., Bagnato, P., Palmigiano, A., Innamorati, G., Rotondo, G., Altimare, D., Venturi, C., Sviderskaya, E. V., Piccirillo, R., Coppola, M., Marigo, V., Incerti, B., Ballabio, A., Surace, E. M., Tacchetti, Carlo, Bennett, D. C., and Schiaffino, M. V.

Published
2008

25. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

Author

Anver, M., Dickins, R., DePinho, R. A., Bennett, D. C., Merlino, G., Ichikawa, T., Sharpless, N. E., Sviderskaya, E. V., Ha, L., Lowe, S., and Krimpenfort, P.

Abstract

Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we show that genetic deficiency in Arf but not p53 facilitates rapid development of melanoma in a genetically engineered mouse model. This difference is accounted for, at least in part, by the unanticipated observation that, unlike fibroblasts, senescence control in melanocytes is strongly regulated by Arf and not p53. Moreover, oncogenic NRAS collaborates with deficiency in Arf, but not p53, to fully transform melanocytes. Our data demonstrate that ARF and p53, although linked in a common pathway, suppress tumorigenesis through distinct, lineage-dependent mechanisms and suggest that ARF helps restrict melanoma progression by executing the oncogene-induced senescence program in benign nevi. Thus, therapeutics designed to restore wild-type p53 function may be insufficient to counter melanoma and other malignancies in which ARF holds p53-independent tumor suppressor activity.

Published
2007
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36. p16/Cyclin-Dependent Kinase Inhibitor 2A Deficiency in Human Melanocyte Senescence, Apoptosis, and Immortalization: Possible Implications for Melanoma Progression

Author

Sviderskaya, E. V., primary, Gray-Schopfer, V. C., additional, Hill, S. P., additional, Smit, N. P., additional, Evans-Whipp, T. J., additional, Bond, J., additional, Hill, L., additional, Bataille, V., additional, Peters, G., additional, Kipling, D., additional, Wynford-Thomas, D., additional, and Bennett, D. C., additional

Published
2003
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48. Hematological and serum biochemical profile of farm emus (Dromaius novaehollandiae) at the onset of their breeding season.

Author

Menon, D. G., Bennett, D. C., Schaefer, A. M., and Cheng, K. M.

Subjects
*HEMATOLOGY, *SERUM, *BIOCHEMISTRY, *EMUS, *POULTRY breeding, *CHICKENS, *BLOOD testing, *METABOLIC disorders, *BODY temperature
Abstract

Blood profiling is a helpful tool in detecting the health status, metabolic diseases, nutritional deficiencies, and welfare of animals. Body weights, body temperatures, hematological and serum biochemical parameters, enzymes, and electrolytes in both sexes of farm emus at the beginning of their breeding season (November in Canada), were determined. The reference interval for each analyte was also calculated. Emus have lower body temperatures (37.2 ± 0.2) than other poultry species. There was no significant between-sex difference in BW, body temperature, and all the hematological and enzyme parameters measured. However, females had significantly (P < 0.001) higher serum calcium, phosphorus, albumin, total protein, globulin, and triglyceride levels than males, probably in preparation for egg laying. We also examined our findings in light of their sex-role reversal in incubation and brooding. Contrary to other avian species in which only females incubate and brood, there was no sex difference in the hematological and enzyme parameters measured in emus. We found that emus are similar to other ratite species with respect to the changes in protein, globulin, triglyceride, and calcium levels. The findings from our study contribute to the database for reference emu hematological and serum enzyme, metabolite, and electrolyte values. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Ivermectin residues in squab.

Author

Bennett, D. C. and Cheng, K. M.

Subjects
*PIGEONS, *IVERMECTIN, *PARASITIC disease treatment, *NEMATODES, *MEAT, *ANTIBIOTIC residues, *DISEASES
Abstract

No drugs have been approved for the treatment of parasitic nematodes in pigeons, but iver-mectin, a broad-spectrum endectocide, has been used extra-label by prescription. Producers currently allow for a 2-wk withdrawal time before marketing squabs. However, because its use is extra-label there is no legal maximum residue limit for ivermectin in squab meat. The purpose of this study was to examine the depletion of ivermectin (passed by the parents to the squabs) from the tissues of squab. Adult pigeons brooding squab were treated with ivermectin in their drinking water (3.3 μg/mL) for 3 d. After dosing the parents, the ivermectin concentration of the breast meat and liver of squabs was found to be greater than the maxi-mum residual limits established for livestock, indicating that ivermectin was transferred from the parents to the squabs. However, ivermectin was not detected in either the breast meat or the livers of squabs 1 wk after dosing. These results indicate that there is a rapid decline in tissue levels of ivermectin in squab. [ABSTRACT FROM AUTHOR]

Published
2012
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