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2. Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study

Author

Supady, Alexander, DellaVolpe, Jeff, Taccone, Fabio Silvio, Scharpf, Dominik, Ulmer, Matthias, Lepper, Philipp M, Halbe, Maximilian, Ziegeler, Stephan, Vogt, Alexander, Ramanan, Raj, Boldt, David, Stecher, Stephanie-Susanne, Montisci, Andrea, Spangenberg, Tobias, Marggraf, Olivier, Kunavarapu, Chandra, Peluso, Lorenzo, Muenz, Sebastian, Buerle, Monica, Nagaraj, Naveen G, Nuding, Sebastian, Toma, Catalin, Gudzenko, Vadim, Stemmler, Hans Joachim, Pappalardo, Federico, Trummer, Georg, Benk, Christoph, Michels, Guido, Duerschmied, Daniel, von zur Muehlen, Constantin, Bode, Christoph, Kaier, Klaus, Brodie, Daniel, Wengenmayer, Tobias, and Staudacher, Dawid L

Subjects
Chemical Engineering, Engineering, Environmental Engineering, Patient Safety, Clinical Research, Rare Diseases, Prevention, Good Health and Well Being, acute respiratory distress syndrome, extracorporeal membrane oxygenation, COVID-19, SARS-CoV-2, Civil Engineering, Chemical engineering, Environmental engineering
Abstract

The role of veno-venous extracorporeal membrane oxygenation therapy (V-V ECMO) in severe COVID-19 acute respiratory distress syndrome (ARDS) is still under debate and conclusive data from large cohorts are scarce. Furthermore, criteria for the selection of patients that benefit most from this highly invasive and resource-demanding therapy are yet to be defined. In this study, we assess survival in an international multicenter cohort of COVID-19 patients treated with V-V ECMO and evaluate the performance of several clinical scores to predict 30-day survival. This is an investigator-initiated retrospective non-interventional international multicenter registry study (NCT04405973, first registered 28 May 2020). In 127 patients treated with V-V ECMO at 15 centers in Germany, Switzerland, Italy, Belgium, and the United States, we calculated the Sequential Organ Failure Assessment (SOFA) Score, Simplified Acute Physiology Score II (SAPS II), Acute Physiology And Chronic Health Evaluation II (APACHE II) Score, Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) Score, Predicting Death for Severe ARDS on V‑V ECMO (PRESERVE) Score, and 30-day survival. In our study cohort which enrolled 127 patients, overall 30-day survival was 54%. Median SOFA, SAPS II, APACHE II, RESP, and PRESERVE were 9, 36, 17, 1, and 4, respectively. The prognostic accuracy for all these scores (area under the receiver operating characteristic-AUROC) ranged between 0.548 and 0.605. The use of scores for the prediction of mortality cannot be recommended for treatment decisions in severe COVID-19 ARDS undergoing V-V ECMO; nevertheless, scoring results below or above a specific cut-off value may be considered as an additional tool in the evaluation of prognosis. Survival rates in this cohort of COVID-19 patients treated with V‑V ECMO were slightly lower than those reported in non-COVID-19 ARDS patients treated with V-V ECMO.

Published
2021

5. List of contributors: volume II

Author

Abutaka, Ahmad, primary, Acton, Matthew, additional, Agerstrand, Cara, additional, Akhmerov, Akbarshakh, additional, Akin, Ibrahim, additional, Aksüt, Mehmet, additional, Alinier, Guillaume, additional, Altınay, Adile Ece, additional, Andreasson, Anders, additional, Aslan, Hacı, additional, Aydın, Sibel, additional, Behnes, Michael, additional, Belliato, Mirko, additional, Benazzo, Alberto, additional, Benk, Christoph, additional, Beyersdorf, Friedhelm, additional, Bohman, J. Kyle, additional, Brehm, Christoph, additional, Brixius, Sam, additional, Brunsvold, Melissa E., additional, Bulander, Robert E., additional, Çelik, Mevlüt, additional, Chatterjee, Subhasis, additional, Chen, Yih-Sharng, additional, Chien, Jung-Yien, additional, Chung, Jayer, additional, Clark, Joseph B., additional, Davarci, Orhun, additional, Dhaliwal, Bhalinder, additional, Dhundi, Ujwal, additional, Diaz Soto, Juan, additional, Doğan, Güneş, additional, Erkılınç, Atakan, additional, Évora, Patricia Martinez, additional, Evora, Paulo Roberto B., additional, Flatley, Meaghan, additional, Fowles, Jo-anne, additional, Geoffrion, Tracy R., additional, Giuliani, Gabriel, additional, Goerlich, Corbin E., additional, Green, Estelle, additional, Gücün, Murat, additional, Günay, Deniz, additional, Haam, Seokjin, additional, Hadley-Brown, Andrew, additional, Hanke, Jasmin Sarah, additional, Holcomb, Ryan M., additional, Hötzenecker, Konrad, additional, Insorsi, Angelo, additional, Jacob, Cecilio, additional, James, Leslie, additional, Jung, Jae-Seung, additional, Keller, Steven P., additional, Ki, Katrina, additional, Kilic, Ahmet, additional, Koshy, Anoop Ninan, additional, Kılıç, Nazlı, additional, Kırali, Kaan, additional, Labib, Ahmed, additional, Lamba, Harveen K., additional, Lemaitre, Philippe, additional, Liao, Kenneth K., additional, Liao, Ting-Yu, additional, Maeda, Katsuhide, additional, Maltais, Simon, additional, Menekşe, Şirin, additional, Mitra, Saikat, additional, Moazami, Nader, additional, Myers, John, additional, Myers, John L., additional, Nicolò, Patroniti, additional, Onyemkpa, Chibueze J., additional, Palanzo, David, additional, Pallister, Zachary S., additional, Patel, Krishna, additional, Pellegrini, Andrea, additional, Polat, Aytaç, additional, Pooth, Jan-Steffen, additional, Radosevich, Misty, additional, Ramanathan, Kollengode, additional, Ramzy, Danny, additional, Ravn, Hanne Berg, additional, Sarıkaya, Sabit, additional, Schmidt, Henrik, additional, Schmitto, Jan D., additional, Schupp, Tobias, additional, Serrao, Gregory W., additional, Seubert, Christoph N., additional, Shafii, Alexis E., additional, Sharma, Samin, additional, Shekar, Kiran, additional, Short, Briana, additional, Smith, Deane E., additional, Sommer, Wiebke, additional, Srisooksai, Gevalin, additional, Su, Lilly, additional, Suero, Orlando R., additional, Sugeir, Shihab, additional, Suttner, Denise, additional, Swol, Justyna, additional, Taghavi, Shahrokh, additional, Taş, Serpil Gezer, additional, Trummer, Georg, additional, Ündar, Akif, additional, Veronesi, Roberto, additional, Warnecke, Gregor, additional, Worku, Elliott T., additional, and Yerli, Ismail, additional

Published
2023
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7. List of contributors: volume I

Author

Adademir, Taylan, primary, Altaş, Özge, additional, Anastasiadis, Kyriakos, additional, Antonitsis, Polychronis, additional, Argiriadou, Helena, additional, Athanasiou, Thanos, additional, Avgerinos, Dimitrios V., additional, Bannon, Paul G., additional, Bates, Michael J., additional, Baysal, Pınar Karaca, additional, Baş, Tolga, additional, Benk, Christoph, additional, Bernabei, Annalisa, additional, Bertolin, Stephanie, additional, Bouchez, Stefaan, additional, Boyd, Walter Doug, additional, Can, Mehmet, additional, Çankaya, Nuray, additional, Carrel, Thierry, additional, Çekmecelioğlu, Davut, additional, Chitwood, W. Randolph, additional, Cibin, Giorgia, additional, Clark, Stephen, additional, Cooper, John R., additional, Coselli, Joseph S., additional, Dan, Yongwook, additional, De Piero, Maria Elena, additional, De Somer, Filip M.J.J., additional, Deliopoulos, Apostolos, additional, Duman, Mustafa, additional, Eke, Uğur, additional, El-Sayed Ahmed, Magdy M., additional, Ersoy, Ercan, additional, Évora, Patricia Martinez, additional, Evora, Paulo Roberto B., additional, Fabozzo, Assunta, additional, Faggian, Giuseppe, additional, Fanning, Jonathon Paul, additional, Fergadi, Maria, additional, Fisher, David, additional, Fitzgerald, David, additional, Francica, Alessandra, additional, Frazier, O. Howard, additional, Galdieri, Nicola, additional, Gerosa, Gino, additional, Giuliani, Gabriel, additional, Gordon, Katherine L., additional, Güney, Pınar Atagün, additional, Gürcü, Mustafa Emre, additional, Gygax, Erich, additional, Hançer, Hakan, additional, Harky, Amer, additional, Haverich, Axel, additional, Holcomb, Ryan M., additional, Hon, Kay, additional, Ibáñez, Cristina, additional, Jacob, Cecilio, additional, Kalangos, Afksendiyos, additional, Kibler, Kathleen, additional, Kritharides, Leonard, additional, Krupnick, Alexander S., additional, Kılıç, Şefika, additional, Kırali, Kaan, additional, Kızmaz, Yeşim Uygun, additional, Landoni, Giovanni, additional, Lang, Peter, additional, Leibowitz, Joshua L., additional, Linardi, Daniele, additional, Lomivorotov, Vladimir, additional, Lomivorotova, Ludmila, additional, Longnus, Sarah Henning, additional, Luciani, Giovanni Battista, additional, Magouliotis, Dimitrios, additional, Maier, Sven, additional, Maj, Giulia, additional, Mariani, Silvia, additional, Melamed, Naomi, additional, Molina-Andujar, Alícia, additional, Murkin, John M., additional, Myers, Gerard J., additional, Mylonas, Konstantinos S., additional, Myneni, Manoj, additional, Nifong, L. Wiley, additional, Onorati, Francesco, additional, Orozco-Sevilla, Vicente, additional, Özer, Tanıl, additional, Özgür, Mustafa Mert, additional, Oğuzhan, Özlem, additional, Oğuş, Halide, additional, Pappalardo, Federico, additional, Patel, Krishna, additional, Pathania, Vikrant, additional, Patlolla, Sri Harsha, additional, Perdomo, Juan, additional, Pisano, Antonio, additional, Poch, Esteban, additional, Polat, Erdal, additional, Prempeh, Agya B.A., additional, Puskas, John D., additional, Quintana, Eduard, additional, Raja, Shahzad G., additional, Rajagopal, Keshava, additional, Ramponi, Fabio, additional, Resley, Justin, additional, Romero García, Carolina Soledad, additional, Rungatscher, Alessio, additional, Sareyyüpoğlu, Başar, additional, Schaff, Hartzell V., additional, Seco, Michael, additional, Shah, Aakash, additional, Shatelen, Nataliia, additional, Stiljan, Hoxha, additional, Sun, Zhonghua, additional, Swol, Justyna, additional, Şimşek, Mine, additional, Tessari, Chiara, additional, Thomas, Mathew, additional, Tropea, Ilaria, additional, Tsui, Steven, additional, Turina, Marko, additional, Ündar, Akif, additional, Vallely, Michael P., additional, Vandewiele, Korneel, additional, Vokshi, Ismail, additional, Wei, Claudia Yu Yao, additional, Wieselthaler, Georg Maximilian, additional, Wright, Kelly, additional, Yük, Hülya, additional, and Zamvar, Vipin, additional

Published
2023
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8. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, De Piero, Maria Elena, Mariani, Silvia, Di Mauro, Michele, Folliguet, Thierry, Taccone, Fabio Silvio, Camporota, Luigi, Swol, Justyna, Wiedemann, Dominik, Belliato, Mirko, Broman, Lars Mikael, Vuylsteke, Alain, Kassif, Yigal, Scandroglio, Anna Mara, Fanelli, Vito, Gaudard, Philippe, Ledot, Stephane, Barker, Julian, Boeken, Udo, Maier, Sven, Kersten, Alexander, Meyns, Bart, Pozzi, Matteo, Pedersen, Finn M, Schellongowski, Peter, Kirali, Kaan, Barrett, Nicholas, Riera, Jordi, Mueller, Thomas, Belohlavek, Jan, Lo Coco, Valeria, Van der Horst, Iwan C C, Van Bussel, Bas C T, Schnabel, Ronny M, Delnoij, Thijs, Bolotin, Gil, Lorini, Luca, Schmiady, Martin O, Schibilsky, David, Kowalewski, Mariusz, Pinto, Luis F, Silva, Pedro E, Kornilov, Igor, Blandino Ortiz, Aaron, Vercaemst, Leen, Finney, Simon, Roeleveld, Peter P, Di Nardo, Matteo, Hennig, Felix, Antonini, Marta Velia, Davidson, Mark, Jones, Tim J, Staudinger, Thomas, Mair, Peter, Kilo, Juliane, Krapf, Christoph, Erbert, Kathrin, Peer, Andreas, Bonaros, Nikolaos, Kotheletner, Florian, Krenner Mag, Niklas, Shestakova, Liana, Hermans, Greet, Dauwe, Dieter, Meersseman, Philippe, Stockman, Bernard, Nobile, Leda, Lhereux, Olivier, Nrasseurs, Alexandre, Creuter, Jacques, De Backer, Daniel, Giglioli, Simone, Michiels, Gregoire, Foulon, Pierre, Raes, Matthias, Rodrigus, Inez, Allegaert, Matthias, Jorens, Philippe, Debeucklare, Gerd, Piagnerelli, Michael, Biston, Patrick, Peperstraete, Harlinde, Vandewiele, Komeel, Germay, Olivier, Vandeweghe, Dimitri, Havrin, Sven, Bourgeois, Marc, Lagny, Marc-Gilbert, Alois, Genette, Lavios, Nathalie, Misset, Benoit, Courcelle, Romain, Timmermans, Philippe J, Yilmaz, Alaaddin, Vantomout, Michiel, Lehaen, Jerone, Jassen, Ame, Guterman, Herbert, Strauven, Maarten, Lormans, Piet, Verhamme, Bruno, Vandewaeter, catherine, Bonte, Frederik, Vionne, Dominique, Balik, Martin, Blàha, Jan, Lips, Michal, Othal, Michal, Bursa, Filip, Spacek, Radim, Christensen, Steffen, Jorgensen, Vibeke, Sorensen, Marc, Madsen, Soren A, Puss, Severin, Beljantsev, Aleksandr, Saiydoun, gabriel, Fiore, Antonio, Colson, Pascal, Bazalgette, Florian, Capdevila, Xavier, Kollen, Sebastien, Muller, Laurent, Obadia, Jean-Francois, Dubien, Pierre-Yves, Ajrhourh, Lucrezia, Guinot, Pierre G, Zarka, Jonathan, Besserve, Patricia, Malfertheiner, Maximilian V, Dreier, Esther, Heinze, Birgit, Akhyari, Payam, Lichtenberg, Artur, Aubin, Hug, Assman, Alexander, Saeed, Diyar, Thiele, Holger, Baumgaertel, Matthias, Schmitto, Jan D, Ruslan, Natanov, Haverich, Axel, Thielmann, Matthias, Brenner, Thorsten, Ruhpawar, Arjang, Benk, Christoph, Czerny, Martin, Staudacher, Dawid L, Beyersdorf, Fridhelm, Kalbhenn, Johannes, Henn, Philipp, Popov, Aron-Frederik, Iuliu, Torje, Muellenbach, Ralf, Reyher, Christian, Rolfes, Caroline, Lotz, Gosta, Sonntagbauer, Michael, Winkels, Helen, Fichte, Julia, Stohr, Robert, Kalverkamp, Sebastian, Karagiannidis, Christian, Schafer, Simone, Svetlitchny, Alexei, Hopf, Hans-Bernd, Jarczak, Dominik, Groesdonk, Heinirich, Rommer, Magdalena, Hirsch, Jan, Kaehny, Christian, Soufleris, Dimitros, Gavriilidis, Georgios, Pontikis, Kostantinos, Kyriakopoulou, Magdalini, Kyriakoudi, Anna, O'Brien, Serena, Conrick-Martin, Ian, Carton, Edmund, Makhoul, Maged, Ben-Ari, Josef, Hadash, Amir, Kogan, Alexander, Kassif Lerner, Reut, Abu-Shakra, Anas, Matan, Moshe, Balawona, Ahmad, Kachel, Erez, Altshuler, Roman, Galante, Ori, Fuchs, Lior, Almog, Yaniv, Ishay, Yaron S, Lichter, Yael, Gal-oz, Amir, Carmi, Uri, Nini, Asaph, Soroksky, Arie, Dekel, Hagi, Rozman, Ziv, Tayem, Emad, Ilgiyaev, Eduard, Hochman, Yuval, Miltau, daniel, Rapoport, Avigal, Eden, Arieh, Kompanietz, Dmitry, Yousif, Michael, Golos, Miri, Grazioli, Lorenzo, Ghitti, Davide, Loforte, Antonio, Di Luca, Daniela, Baiocchi, Massimo, Pacini, Davide, Cappai, Antioco, Meani, Paolo, Mondino, Michele, Russo, Claudio F, Ranucci, Marco, Fina, Dario, Cotza, Marco, Ballotta, Andrea, Landoni, Giovanni, Nardelli, Pasquale, Fominski, Eygeny V, Brazzi, Luca, Montrucchio, Giorgia, Sales, Gabriele, Simonetti, Umberto, Livigni, Sergio, Silengo, Daniela, Arena, Giulia, Sovatzis, Stefania S, Degani, Antonella, Riccardi, Mariachiara, Milanesi, Elisa, Raffa, Giuseppe, Martucci, Gennaro, Arcadipane, Antonio, Panarello, Giovanna, Chiarini, Giovanni, Cattaneo, Sergio, Puglia, Carmine, Benussi, Stefano, Foti, Giuseppe, Giani, Marco, Bombino, Michela, Costa, Maria Cristina, Rona, Roberto, Avalli, Leonello, Donati, Abele, Carozza, Roberto, Gasparri, Francesco, Carsetti, Andrea, Picichè, Marco, Marinello, Anna, Danzi, Vinicio, Zanin, Anita, Condello, Ignazio, Fiore, Flavio, Moscarelli, Marco, Nasso, Giuseppe, Speziale, Giuseppe, Sandrelli, Luca, Montalto, Andrea, Musumeci, Francesco, Circelli, Alessandro, Russo, Emanuele, Agnoletti, Vanni, Rociola, Ruggero, Milano, Aldo D, Pilato, Emanuele, Comentale, Giuseppe, Montisci, Andrea, Alessandri, Francesco, Tosi, Antonella, Pugliese, Francesco, Giordano, Giovanni, Carelli, Simone, Grieco, Domenico L, Dell'Anna, Antonio M, Antonelli, Massimo, Ramoni, Enrico, Zulueta, Josè, Del Giglio, Mauro, Petracca, Sebastiano, Bertini, Pietro, Guarracino, Fabio, De Simone, Luigi, Angeletti, Paolo M, Forfori, Francesco, Taraschi, Francesco, Quintiliani, Veronica N, Samalavicius, Robertas, Jankuviene, Agne, Scupakova, Nadezda, Urbonas, Karolis, Kapturauskas, Juozas, Soerensen, Gro, Suwalski, Piotr, Linhares Santos, Luis, Marques, Ana, Miranda, Marisa, Teixeira, Sonia, Salgueiro, Andrea, Pereira, Filipe, Ketskalo, Michail, Tsarenko, Sergey, Shilova, Alexandra, Afukov, Ivan, Popugaev, Konstantin, Minin, Sergei, Shelukhin, Daniil, Malceva, Olga, Gleb, Moroz, Skopets, Alexander, Kornelyuk, Roman, Kulikov, Alexandr, Okhrimchuk, Vadim, Turchaninov, Alexandr, Petrushin, Maxim, Sheck, Anastasia, Mekulov, Akhmed, Ciryateva, Svetlana, Urusov, Dmitry, Gorjup, Vojka, Golicnik, Alenka, Goslar, Tomaz, Ferrer, Ricard, Martinez-Martinez, Maria, Argudo, Eduard, Palmer, Neiser, De Pablo Sanchez, Raul, Juan Higuera, Lucas, Arnau Blasco, Lucas, Marquez, Josè A, Sbraga, Fabrizio, Fuset, Mari Paz, De Gopegui, Pablo Ruiz, Claraco, Luis M, De Ayala, Josè A, Peiro, Maranta, Ricart, Pilar, Martinez, Sergio, Chavez, Fernando, Fabra, Marc, Sandoval, elena, Toapanta, David, Carraminana, Albert, Tellez, Adrian, Ososio, Jeysson, Milan, Pablo, Rodriguez, Jorge, Andoni, Garcia, Gutierrez, Carola, Perez de la Sota, Enrique, Eixeres-Esteve, Andrea, Garcia-Maellas, Maria Teresa, Gutierrez-Gutierrez, Judit, Arboleda-Salazar, Rafael, Santa Teresa, Patricia, Jaspe, Alexis, Garrido, Alberto, Castaneda, Galo, Alcantara, Sara, Martinez, Nuria, Perez, Marina, Villanueva, Hector, Vidal Gonzalez, Anxela, Paez, Juan, Santon, Arnoldo, Perez, Cesar, Lopez, Marta, Rubio Lopez, Maria Isabel, Gordillo, Antonio, Naranjo-Izurieta, Jose, Munoz, Javier, Alcalde, Immaculada, Onieva, Fernando, Gimeno Costa, Ricardo, Perez, Francisco, Madrid, Isabel, Gordon, Monica, Albacete Moreno, Carlos L, Perez, Daniel, Lopez, Nayara, Martinenz, Domingo, Blanco-Schweizer, Pablo, Diez, Cristina, Perez, David, Prieto, Ana, Renedo, Gloria, Bustamante, Elena, Cicuendez, Ramon, Citores, Rafael, Boado, Victoria, Garcia, Katherine, Voces, Roberto, Domezain, Monica, Nunez Martinez, Jose Maria, Vicente, Raimundo, Martin, David, Andreu, Antonio, Gomez Casal, Vanesa, Chico, Ignacio, Menor, Eva Maria, Vara, Sabela, Gamacho, Jose, Perez-Chomon, Helen, Javier Gonzales, Francisco, Barrero, Irene, Martin-Villen, Luis, Fernandez, Esperanza, Mendoza, Maria, Navarro, Joaquin, Colomina Climent, Joaquin, Gonzales-Perez, Alfredo, Muniz-Albaceita, Guillermo, Amado, Laura, Rodriguez, Raquel, Ruiz, Emilio, Eiras, Maria, Grins, Edgars, Magnus, Rosen, Kanetoft, Mikael, Eidevald, Marcus, Watson, Pia, Vogt, Paul R, Steiger, Peter, Aigner, Tobias, Weber, Alberto, Grunefelder, Jurg, Kunz, Martin, Grapow, Martin, Aymard, Thierry, Reser, Diana, Agus, Gianluca, Consiglio, Jolanda, Haenggi, Matthias, Hansjoerg, Jenni, Iten, Manuela, Doeble, Thomas, Zenklusen, Urs, Bechtold, Xavier, Faedda, Giovanni, Iafrate, Manuel, Rohjer, Amanda, Bergamaschi, Layla, Maessen, Jos, Reis Miranda, Dinis, Endeman, H, Gommers, D, Meuwese, C, Maas, Jacinta, Van Gijlswijk, MJ, Van Berg, RN, Candura, Dario, Van der Linden, Marcel, Kant, Merijin, Van der Heijden, JJ, Scholten, Eric, Van Belle-van Haren, Nicole, Lagrand, WK, Vlaar, Alexander P, De Jong, Syste, Cander, Basar, Sargin, Murat, Ugur, Murat, Kaygin, Mehmet A, Daly, Kathleen, Agnew, Nicola, Head, Laura, Kelly, Laura, Anoma, Gunawardena, Russell, Clare, Aquino, Verna, Scott, Ian, Flemming, Lucy, Gillon, Stuart, Moore, Olivia, Gelandt, Elton, Auzinger, George, Patel, Sameer, and Loveridge, Robert

Published
2023
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13. Brain vulnerability and viability after ischaemia

Author

Daniele, Stefano G., Trummer, Georg, Hossmann, Konstantin A., Vrselja, Zvonimir, Benk, Christoph, Gobeske, Kevin T., Damjanovic, Domagoj, Andrijevic, David, Pooth, Jan-Steffen, Dellal, David, Beyersdorf, Friedhelm, and Sestan, Nenad

Published
2021
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14. Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial

Author

Supady, Alexander, Weber, Enya, Rieder, Marina, Lother, Achim, Niklaus, Tim, Zahn, Timm, Frech, Franziska, Müller, Sissi, Kuhl, Moritz, Benk, Christoph, Maier, Sven, Trummer, Georg, Flügler, Annabelle, Krüger, Kirsten, Sekandarzad, Asieb, Stachon, Peter, Zotzmann, Viviane, Bode, Christoph, Biever, Paul M, Staudacher, Dawid, Wengenmayer, Tobias, Graf, Erika, and Duerschmied, Daniel

Published
2021
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15. Treatment of Refractory Cardiac Arrest by Controlled Reperfusion of the Whole Body:A Multicenter, Prospective Observational Study

Author

Trummer, Georg, Benk, Christoph, Pooth, Jan Steffen, Wengenmayer, Tobias, Supady, Alexander, Staudacher, Dawid L., Damjanovic, Domagoj, Lunz, Dirk, Wiest, Clemens, Aubin, Hug, Lichtenberg, Artur, Dünser, Martin W., Szasz, Johannes, Dos Reis Miranda, Dinis, van Thiel, Robert J., Gummert, Jan, Kirschning, Thomas, Tigges, Eike, Willems, Stephan, Beyersdorf, Friedhelm, Trummer, Georg, Benk, Christoph, Pooth, Jan Steffen, Wengenmayer, Tobias, Supady, Alexander, Staudacher, Dawid L., Damjanovic, Domagoj, Lunz, Dirk, Wiest, Clemens, Aubin, Hug, Lichtenberg, Artur, Dünser, Martin W., Szasz, Johannes, Dos Reis Miranda, Dinis, van Thiel, Robert J., Gummert, Jan, Kirschning, Thomas, Tigges, Eike, Willems, Stephan, and Beyersdorf, Friedhelm

Abstract

Background: Survival following cardiac arrest (CA) remains poor after conventional cardiopulmonary resuscitation (CCPR) (6–26%), and the outcomes after extracorporeal cardiopulmonary resuscitation (ECPR) are often inconsistent. Poor survival is a consequence of CA, low-flow states during CCPR, multi-organ injury, insufficient monitoring, and delayed treatment of the causative condition. We developed a new strategy to address these issues. Methods: This all-comers, multicenter, prospective observational study (69 patients with in- and out-of-hospital CA (IHCA and OHCA) after prolonged refractory CCPR) focused on extracorporeal cardiopulmonary support, comprehensive monitoring, multi-organ repair, and the potential for out-of-hospital cannulation and treatment. Result: The overall survival rate at hospital discharge was 42.0%, and a favorable neurological outcome (CPC 1+2) at 90 days was achieved for 79.3% of survivors (CPC 1+2 survival 33%). IHCA survival was very favorable (51.7%), as was CPC 1+2 survival at 90 days (41%). Survival of OHCA patients was 35% and CPC 1+2 survival at 90 days was 28%. The subgroup of OHCA patients with pre-hospital cannulation showed a superior survival rate of 57.1%. Conclusions: This new strategy focusing on repairing damage to multiple organs appears to improve outcomes after CA, and these findings should provide a sound basis for further research in this area.

Published
2024

17. Extracorporeal Membrane Oxygenation in Intoxication and Overdoses: A Systematic Review.

Author

Maier, Sven, Rösner, Lisa, Saemann, Lars, Sogl, Jonas, Beyersdorf, Friedhelm, Trummer, Georg, Czerny, Martin, and Benk, Christoph

Subjects
EXTRACORPOREAL membrane oxygenation, CARDIOGENIC shock, HOSPITAL admission & discharge, DRUG overdose, CARDIAC arrest, CHILD patients
Abstract

Extracorporeal membrane oxygenation (ECMO) has been increasingly applied over recent decades to treat severe cardiogenic shock and acute lung failure and cardiac arrest of various causes. Acute intoxication with therapeutic substances or other chemical substances can cause severe cardiogenic shock or even cardiac arrest. The purpose of this study was to conduct a qualitative systematic review of ECMO use in intoxication and poisoning. We searched the PubMed, Medline, and Web of Science databases from January 1971 to December 2021 and selected appropriate studies according to our inclusion and exclusion criteria to evaluate the role of ECMO in intoxication and poisoning systematically. Survival at hospital discharge was examined to describe the outcome. The search resulted in 365 publications after removing duplicates. In total, 190 full-text articles were assessed for eligibility. A total of 145 articles from 1985 to 2021 were examined in our final qualitative analysis. A total of 539 (100%) patients were included (mean age: 30.9 ± 16.6 years), with a distribution of n = 64 (11.9%) cases with venovenous (vv) ECMO, n = 218 (40.4%) cases with venoarterial (va) ECMO, and n = 257 (47.7%) cases with cardiac arrest and extracorporeal cardiopulmonary resuscitation. Survival at hospital discharge was 61.0% for all patients, 68.8% for vaECMO, 75% for vvECMO, and 50.9% for extracorporeal cardiopulmonary resuscitation. When used and reported, ECMO seems to be a valid tool for adult and pediatric patients suffering intoxication from various pharmaceutical and nonpharmaceutical substances due to a high survival rate at hospital discharge. [ABSTRACT FROM AUTHOR]

Published
2024
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23. The Impact of Head Position on Neurological and Histopathological Outcome Following Controlled Automated Reperfusion of the Whole Body (CARL) in a Pig Model

Author

Damjanovic, Domagoj, primary, Pooth, Jan-Steffen, additional, Liu, Yechi, additional, Frensch, Fabienne, additional, Wolkewitz, Martin, additional, Haberstroh, Joerg, additional, Doostkam, Soroush, additional, Cristina Schmitz, Heidi Ramona, additional, Foerster, Katharina, additional, Taunyane, Itumeleng, additional, Neubert, Tabea, additional, Scherer, Christian, additional, Diel, Patric, additional, Benk, Christoph, additional, Beyersdorf, Friedhelm, additional, and Trummer, Georg, additional

Published
2023
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27. Development of an in-vitro model for extracorporeal blood pumps to study the effects of artificial pulsatility on human blood

Author

Zieger, Barbara, primary, Schneider, Denise, additional, Brixius, Sam Joé, additional, Scherer, Christian, additional, Buchwald, Armin, additional, Trummer, Georg, additional, Czerny, Martin, additional, Beyersdorf, Friedhelm, additional, Busch, Hans-Jörg, additional, Benk, Christoph, additional, and Pooth, Jan-Steffen, additional

Published
2023
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29. Treatment of Refractory Cardiac Arrest by Controlled Reperfusion of the Whole Body: A Multicenter, Prospective Observational Study.

Author

Trummer, Georg, Benk, Christoph, Pooth, Jan-Steffen, Wengenmayer, Tobias, Supady, Alexander, Staudacher, Dawid L., Damjanovic, Domagoj, Lunz, Dirk, Wiest, Clemens, Aubin, Hug, Lichtenberg, Artur, Dünser, Martin W., Szasz, Johannes, Dos Reis Miranda, Dinis, van Thiel, Robert J., Gummert, Jan, Kirschning, Thomas, Tigges, Eike, Willems, Stephan, and Beyersdorf, Friedhelm

Subjects
*CARDIAC arrest, *CARDIOPULMONARY resuscitation, *LONGITUDINAL method, *REPERFUSION, *SCIENTIFIC observation
Abstract

Background: Survival following cardiac arrest (CA) remains poor after conventional cardiopulmonary resuscitation (CCPR) (6–26%), and the outcomes after extracorporeal cardiopulmonary resuscitation (ECPR) are often inconsistent. Poor survival is a consequence of CA, low-flow states during CCPR, multi-organ injury, insufficient monitoring, and delayed treatment of the causative condition. We developed a new strategy to address these issues. Methods: This all-comers, multicenter, prospective observational study (69 patients with in- and out-of-hospital CA (IHCA and OHCA) after prolonged refractory CCPR) focused on extracorporeal cardiopulmonary support, comprehensive monitoring, multi-organ repair, and the potential for out-of-hospital cannulation and treatment. Result: The overall survival rate at hospital discharge was 42.0%, and a favorable neurological outcome (CPC 1+2) at 90 days was achieved for 79.3% of survivors (CPC 1+2 survival 33%). IHCA survival was very favorable (51.7%), as was CPC 1+2 survival at 90 days (41%). Survival of OHCA patients was 35% and CPC 1+2 survival at 90 days was 28%. The subgroup of OHCA patients with pre-hospital cannulation showed a superior survival rate of 57.1%. Conclusions: This new strategy focusing on repairing damage to multiple organs appears to improve outcomes after CA, and these findings should provide a sound basis for further research in this area. [ABSTRACT FROM AUTHOR]

Published
2024
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37. A Systematic Review with Meta-Analysis Investigating the Impact of Targeted Perfusion Parameters during Extracorporeal Cardiopulmonary Resuscitation in Out-of-Hospital and Inhospital Cardiac Arrest

Author

Saemann, Lars, Maier, Sven, Rösner, Lisa, Kohl, Matthias, Schmucker, Christine, Scherer, Christian, Trummer, Georg, Beyersdorf, Friedhelm, and Benk, Christoph

Subjects
Original Articles
Abstract

Evidence regarding perfusion conditions during extracorporeal cardiopulmonary resuscitation (ECPR) is rare. Therefore, we investigated the impact of perfusion parameters on neurologic outcome and survival in patients with in- or out-of-hospital cardiac arrest (IHCA; OHCA) treated with ECPR. We performed a systematic review with meta-analysis. The focus was set on perfusion parameters and their impact on survival and a goal neurological outcome using the cerebral performance category score of 1–2. We conducted random- and mixed-effects meta-analyses and computed pooled estimates and 95% confidence intervals (CI). We included a total of n = 1,282 ECPR (100%) patients from 20 ECPR studies. The target values of flow and mean arterial pressure (MAP) were frequently available. We transferred flow and MAP target values to high, medium, and low categories. The meta-analysis could not demonstrate a single effect of flow or MAP on outcome variables. In a second mixed-effects model, the combined occurrence of targeted flow and MAP as medium and high showed a significant effect on survival (OHCA: 52%, 95% CI: 29%, 74%; IHCA: 60%, 95% CI: 35%, 85%) and on neurological outcomes (OHCA: 53%, 95% CI: 27%, 78%; IHCA: 62%, 95% CI: 38%, 86%). Random-effects analysis showed also that IHCA led to a significant 11% (p = 0.006; 95% CI: 3%, 18%) improvement in survival and 12% (p = .005; 95% CI: 4%, 21%) improvement in neurological outcomes compared to OHCA. A combination of medium flow and high MAP showed advantages in survival and for neurological outcomes. We also identified improved outcomes for IHCA.

Published
2022

39. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, primary, De Piero, Maria Elena, additional, Mariani, Silvia, additional, Di Mauro, Michele, additional, Folliguet, Thierry, additional, Taccone, Fabio Silvio, additional, Camporota, Luigi, additional, Swol, Justyna, additional, Wiedemann, Dominik, additional, Belliato, Mirko, additional, Broman, Lars Mikael, additional, Vuylsteke, Alain, additional, Kassif, Yigal, additional, Scandroglio, Anna Mara, additional, Fanelli, Vito, additional, Gaudard, Philippe, additional, Ledot, Stephane, additional, Barker, Julian, additional, Boeken, Udo, additional, Maier, Sven, additional, Kersten, Alexander, additional, Meyns, Bart, additional, Pozzi, Matteo, additional, Pedersen, Finn M, additional, Schellongowski, Peter, additional, Kirali, Kaan, additional, Barrett, Nicholas, additional, Riera, Jordi, additional, Mueller, Thomas, additional, Belohlavek, Jan, additional, Lorusso, Roberto, additional, Lo Coco, Valeria, additional, Van der Horst, Iwan C C, additional, Van Bussel, Bas C T, additional, Schnabel, Ronny M, additional, Delnoij, Thijs, additional, Bolotin, Gil, additional, Lorini, Luca, additional, Schmiady, Martin O, additional, Schibilsky, David, additional, Kowalewski, Mariusz, additional, Pinto, Luis F, additional, Silva, Pedro E, additional, Kornilov, Igor, additional, Blandino Ortiz, Aaron, additional, Vercaemst, Leen, additional, Finney, Simon, additional, Roeleveld, Peter P, additional, Di Nardo, Matteo, additional, Hennig, Felix, additional, Antonini, Marta Velia, additional, Davidson, Mark, additional, Jones, Tim J, additional, Staudinger, Thomas, additional, Mair, Peter, additional, Kilo, Juliane, additional, Krapf, Christoph, additional, Erbert, Kathrin, additional, Peer, Andreas, additional, Bonaros, Nikolaos, additional, Kotheletner, Florian, additional, Krenner Mag, Niklas, additional, Shestakova, Liana, additional, Hermans, Greet, additional, Dauwe, Dieter, additional, Meersseman, Philippe, additional, Stockman, Bernard, additional, Nobile, Leda, additional, Lhereux, Olivier, additional, Nrasseurs, Alexandre, additional, Creuter, Jacques, additional, De Backer, Daniel, additional, Giglioli, Simone, additional, Michiels, Gregoire, additional, Foulon, Pierre, additional, Raes, Matthias, additional, Rodrigus, Inez, additional, Allegaert, Matthias, additional, Jorens, Philippe, additional, Debeucklare, Gerd, additional, Piagnarelli, Michael, additional, Biston, Patrick, additional, Peperstraete, Harlinde, additional, Vandewiele, Komeel, additional, Germay, Olivier, additional, Vandeweghe, Dimitri, additional, Havrin, Sven, additional, Bourgeois, Marc, additional, Lagny, Marc-Gilbert, additional, Alois, Genette, additional, Lavios, Nathalie, additional, Misset, Benoit, additional, Courcelle, Romain, additional, Timmermans, Philippe J, additional, Yilmaz, Alaaddin, additional, Vantomout, Michiel, additional, Lehaen, Jerone, additional, Jassen, Ame, additional, Guterman, Herbert, additional, Strauven, Maarten, additional, Lormans, Piet, additional, Verhamme, Bruno, additional, Vandewaeter, catherine, additional, Bonte, Frederik, additional, Vionne, Dominique, additional, Balik, Martin, additional, Blàha, Jan, additional, Lips, Michal, additional, Othal, Michal, additional, Bursa, Filip, additional, Spacek, Radim, additional, Christensen, Steffen, additional, Jorgensen, Vibeke, additional, Sorensen, Marc, additional, Madsen, Soren A, additional, Puss, Severin, additional, Beljantsev, Aleksandr, additional, Saiydoun, gabriel, additional, Fiore, Antonio, additional, Colson, Pascal, additional, Bazalgette, Florian, additional, Capdevila, Xavier, additional, Kollen, Sebastien, additional, Muller, Laurent, additional, Obadia, Jean-Francois, additional, Dubien, Pierre-Yves, additional, Ajrhourh, Lucrezia, additional, Guinot, Pierre G, additional, Zarka, Jonathan, additional, Besserve, Patricia, additional, Malfertheiner, Maximilian V, additional, Dreier, Esther, additional, Heinze, Birgit, additional, Akhyari, Payam, additional, Lichtenberg, Artur, additional, Aubin, Hug, additional, Assman, Alexander, additional, Saeed, Diyar, additional, Thiele, Holger, additional, Baumgaertel, Matthias, additional, Schmitto, Jan D, additional, Ruslan, Natanov, additional, Haverich, Axel, additional, Thielmann, Matthias, additional, Brenner, Thorsten, additional, Ruhpawar, Arjang, additional, Benk, Christoph, additional, Czerny, Martin, additional, Staudacher, Dawid L, additional, Beyersdorf, Fridhelm, additional, Kalbhenn, Johannes, additional, Henn, Philipp, additional, Popov, Aron-Frederik, additional, Iuliu, Torje, additional, Muellenbach, Ralf, additional, Reyher, Christian, additional, Rolfes, Caroline, additional, Lotz, Gosta, additional, Sonntagbauer, Michael, additional, Winkels, Helen, additional, Fichte, Julia, additional, Stohr, Robert, additional, Kalverkamp, Sebastian, additional, Karagiannidis, Christian, additional, Schafer, Simone, additional, Svetlitchny, Alexei, additional, Hopf, Hans-Bernd, additional, Jarczak, Dominik, additional, Groesdonk, Heinirich, additional, Rommer, Magdalena, additional, Hirsch, Jan, additional, Kaehny, Christian, additional, Soufleris, Dimitros, additional, Gavriilidis, Georgios, additional, Pontikis, Kostantinos, additional, Kyriakopoulou, Magdalini, additional, Kyriakoudi, Anna, additional, O'Brien, Serena, additional, Conrick-Martin, Ian, additional, Carton, Edmund, additional, Makhoul, Maged, additional, Ben-Ari, Josef, additional, Hadash, Amir, additional, Kogan, Alexander, additional, Kassif Lerner, Reut, additional, Abu-Shakra, Anas, additional, Matan, Moshe, additional, Balawona, Ahmad, additional, Kachel, Erez, additional, Altshuler, Roman, additional, Galante, Ori, additional, Fuchs, Lior, additional, Almog, Yaniv, additional, Ishay, Yaron S, additional, Lichter, Yael, additional, Gal-oz, Amir, additional, Carmi, Uri, additional, Nini, Asaph, additional, Soroksky, Arie, additional, Dekel, Hagi, additional, Rozman, Ziv, additional, Tayem, Emad, additional, Ilgiyaev, Eduard, additional, Hochman, Yuval, additional, Miltau, daniel, additional, Rapoport, Avigal, additional, Eden, Arieh, additional, Kompanietz, Dmitry, additional, Yousif, Michael, additional, Golos, Miri, additional, Grazioli, Lorenzo, additional, Ghitti, Davide, additional, Loforte, Antonio, additional, Di Luca, Daniela, additional, Baiocchi, Massimo, additional, Pacini, Davide, additional, Cappai, Antioco, additional, Meani, Paolo, additional, Mondino, Michele, additional, Russo, Claudio F, additional, Ranucci, Marco, additional, Fina, Dario, additional, Cotza, Marco, additional, Ballotta, Andrea, additional, Landoni, Giovanni, additional, Nardelli, Pasquale, additional, Fominski, Eygeny V, additional, Brazzi, Luca, additional, Montrucchio, Giorgia, additional, Sales, Gabriele, additional, Simonetti, Umberto, additional, Livigni, Sergio, additional, Silengo, Daniela, additional, Arena, Giulia, additional, Sovatzis, Stefania S, additional, Degani, Antonella, additional, Riccardi, Mariachiara, additional, Milanesi, Elisa, additional, Raffa, Giuseppe, additional, Martucci, Gennaro, additional, Arcadipane, Antonio, additional, Panarello, Giovanna, additional, Chiarini, Giovanni, additional, Cattaneo, Sergio, additional, Puglia, Carmine, additional, Benussi, Stefano, additional, Foti, Giuseppe, additional, Giani, Marco, additional, Bombino, Michela, additional, Costa, Maria Cristina, additional, Rona, Roberto, additional, Avalli, Leonello, additional, Donati, Abele, additional, Carozza, Roberto, additional, Gasparri, Francesco, additional, Carsetti, Andrea, additional, Picichè, Marco, additional, Marinello, Anna, additional, Danzi, Vinicio, additional, Zanin, Anita, additional, Condello, Ignazio, additional, Fiore, Flavio, additional, Moscarelli, Marco, additional, Nasso, Giuseppe, additional, Speziale, Giuseppe, additional, Sandrelli, Luca, additional, Montalto, Andrea, additional, Musumeci, Francesco, additional, Circelli, Alessandro, additional, Russo, Emanuele, additional, Agnoletti, Vanni, additional, Rociola, Ruggero, additional, Milano, Aldo D, additional, Pilato, Emanuele, additional, Comentale, Giuseppe, additional, Montisci, Andrea, additional, Alessandri, Francesco, additional, Tosi, Antonella, additional, Pugliese, Francesco, additional, Giordano, Giovanni, additional, Carelli, Simone, additional, Grieco, Domenico L, additional, Dell'Anna, Antonio M, additional, Antonelli, Massimo, additional, Ramoni, Enrico, additional, Zulueta, Josè, additional, Del Giglio, Mauro, additional, Petracca, Sebastiano, additional, Bertini, Pietro, additional, Guarracino, Fabio, additional, De Simone, Luigi, additional, Angeletti, Paolo M, additional, Forfori, Francesco, additional, Taraschi, Francesco, additional, Quintiliani, Veronica N, additional, Samalavicius, Robertas, additional, Jankuviene, Agne, additional, Scupakova, Nadezda, additional, Urbonas, Karolis, additional, Kapturauskas, Juozas, additional, Soerensen, Gro, additional, Suwalski, Piotr, additional, Linhares Santos, Luis, additional, Marques, Ana, additional, Miranda, Marisa, additional, Teixeira, Sonia, additional, Salgueiro, Andrea, additional, Pereira, Filipe, additional, Ketskalo, Michail, additional, Tsarenko, Sergey, additional, Shilova, Alexandra, additional, Afukov, Ivan, additional, Popugaev, Konstantin, additional, Minin, Sergei, additional, Shelukhin, Daniil, additional, Malceva, Olga, additional, Gleb, Moroz, additional, Skopets, Alexander, additional, Kornelyuk, Roman, additional, Kulikov, Alexandr, additional, Okhrimchuk, Vadim, additional, Turchaninov, Alexandr, additional, Petrushin, Maxim, additional, Sheck, Anastasia, additional, Mekulov, Akhmed, additional, Ciryateva, Svetlana, additional, Urusov, Dmitry, additional, Gorjup, Vojka, additional, Golicnik, Alenka, additional, Goslar, Tomaz, additional, Ferrer, Ricard, additional, Martinez-Martinez, Maria, additional, Argudo, Eduard, additional, Palmer, Neiser, additional, De Pablo Sanchez, Raul, additional, Juan Higuera, Lucas, additional, Arnau Blasco, Lucas, additional, Marquez, Josè A, additional, Sbraga, Fabrizio, additional, Fuset, Mari Paz, additional, De Gopegui, Pablo Ruiz, additional, Claraco, Luis M, additional, De Ayala, Josè A, additional, Peiro, Maranta, additional, Ricart, Pilar, additional, Martinez, Sergio, additional, Chavez, Fernando, additional, Fabra, Marc, additional, Sandoval, elena, additional, Toapanta, David, additional, Carraminana, Albert, additional, Tellez, Adrian, additional, Ososio, Jeysson, additional, Milan, Pablo, additional, Rodriguez, Jorge, additional, Andoni, Garcia, additional, Gutierrez, Carola, additional, Perez de la Sota, Enrique, additional, Eixeres-Esteve, Andrea, additional, Garcia-Maellas, Maria Teresa, additional, Gutierrez-Gutierrez, Judit, additional, Arboleda-Salazar, Rafael, additional, Santa Teresa, Patricia, additional, Jaspe, Alexis, additional, Garrido, Alberto, additional, Castaneda, Galo, additional, Alcantara, Sara, additional, Martinez, Nuria, additional, Perez, Marina, additional, Villanueva, Hector, additional, Vidal Gonzalez, Anxela, additional, Paez, Juan, additional, Santon, Arnoldo, additional, Perez, Cesar, additional, Lopez, Marta, additional, Rubio Lopez, Maria Isabel, additional, Gordillo, Antonio, additional, Naranjo-Izurieta, Jose, additional, Munoz, Javier, additional, Alcalde, Immaculada, additional, Onieva, Fernando, additional, Gimeno Costa, Ricardo, additional, Perez, Francisco, additional, Madrid, Isabel, additional, Gordon, Monica, additional, Albacete Moreno, Carlos L, additional, Perez, Daniel, additional, Lopez, Nayara, additional, Martinenz, Domingo, additional, Blanco-Schweizer, Pablo, additional, Diez, Cristina, additional, Perez, David, additional, Prieto, Ana, additional, Renedo, Gloria, additional, Bustamante, Elena, additional, Cicuendez, Ramon, additional, Citores, Rafael, additional, Boado, Victoria, additional, Garcia, Katherine, additional, Voces, Roberto, additional, Domezain, Monica, additional, Nunez Martinez, Jose Maria, additional, Vicente, Raimundo, additional, Martin, David, additional, Andreu, Antonio, additional, Gomez Casal, Vanesa, additional, Chico, Ignacio, additional, Menor, Eva Maria, additional, Vara, Sabela, additional, Gamacho, Jose, additional, Perez-Chomon, Helen, additional, Javier Gonzales, Francisco, additional, Barrero, Irene, additional, Martin-Villen, Luis, additional, Fernandez, Esperanza, additional, Mendoza, Maria, additional, Navarro, Joaquin, additional, Colomina Climent, Joaquin, additional, Gonzales-Perez, Alfredo, additional, Muniz-Albaceita, Guillermo, additional, Amado, Laura, additional, Rodriguez, Raquel, additional, Ruiz, Emilio, additional, Eiras, Maria, additional, Grins, Edgars, additional, Magnus, Rosen, additional, Kanetoft, Mikael, additional, Eidevald, Marcus, additional, Watson, Pia, additional, Vogt, Paul R, additional, Steiger, Peter, additional, Aigner, Tobias, additional, Weber, Alberto, additional, Grunefelder, Jurg, additional, Kunz, Martin, additional, Grapow, Martin, additional, Aymard, Thierry, additional, Reser, Diana, additional, Agus, Gianluca, additional, Consiglio, Jolanda, additional, Haenggi, Matthias, additional, Hansjoerg, Jenni, additional, Iten, Manuela, additional, Doeble, Thomas, additional, Zenklusen, Urs, additional, Bechtold, Xavier, additional, Faedda, Giovanni, additional, Iafrate, Manuel, additional, Rohjer, Amanda, additional, Bergamaschi, Layla, additional, Maessen, Jos, additional, Reis Miranda, Dinis, additional, Endeman, H, additional, Gommers, D, additional, Meuwese, C, additional, Maas, Jacinta, additional, Van Gijlswijk, MJ, additional, Van Berg, RN, additional, Candura, Dario, additional, Van der Linden, Marcel, additional, Kant, Merijin, additional, Van der Heijden, JJ, additional, Scholten, Eric, additional, Van Belle-van Haren, Nicole, additional, Lagrand, WK, additional, Vlaar, Alexander P, additional, De Jong, Syste, additional, Cander, Basar, additional, Sargin, Murat, additional, Ugur, Murat, additional, Kaygin, Mehmet A, additional, Daly, Kathleen, additional, Agnew, Nicola, additional, Head, Laura, additional, Kelly, Laura, additional, Anoma, Gunawardena, additional, Russell, Clare, additional, Aquino, Verna, additional, Scott, Ian, additional, Flemming, Lucy, additional, Gillon, Stuart, additional, Moore, Olivia, additional, Gelandt, Elton, additional, Auzinger, George, additional, Patel, Sameer, additional, and Loveridge, Robert, additional

Published
2022
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40. A Systematic Review with Meta-Analysis Investigating the Impact of Targeted Perfusion Parameters during Extracorporeal Cardiopulmonary Resuscitation in Out-of-Hospital and Inhospital Cardiac Arrest

Author

Saemann, Lars, primary, Maier, Sven, additional, Rösner, Lisa, additional, Kohl, Matthias, additional, Schmucker, Christine, additional, Scherer, Christian, additional, Trummer, Georg, additional, Beyersdorf, Friedhelm, additional, and Benk, Christoph, additional

Published
2022
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42. Carboxyhemoglobin (CO-Hb) Correlates with Hemolysis and Hospital Mortality in Extracorporeal Membrane Oxygenation: A Retrospective Registry

Author

Bemtgen, Xavier, primary, Rilinger, Jonathan, additional, Holst, Manuel, additional, Rottmann, Felix, additional, Lang, Corinna N., additional, Jäckel, Markus, additional, Zotzmann, Viviane, additional, Benk, Christoph, additional, Wengenmayer, Tobias, additional, Supady, Alexander, additional, and Staudacher, Dawid L., additional

Published
2022
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43. OR18 Serum proteome alterations during conventional and extracorporeal resuscitation in pigs

Author

Bernhard, Patrick, primary, Bretthauer, Berit, additional, Brixius, Sam, additional, Bügener, Hannah, additional, Groh, Johannes, additional, Scherer, Christian, additional, Damjanovic, Domagoj, additional, Haberstroh, Jörg, additional, Trummer, Georg, additional, Benk, Christoph, additional, Beyersdorf, Friedhelm, additional, Schilling, Oliver, additional, and Pooth, Jan-Steffen, additional

Published
2022
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44. B07 “Controlled Automated Reperfusion of the whoLe body”: Vision, Translation and Implementation of a New Concept towards Survival and Neurologic Recovery in Patients after Prolonged Resuscitation

Author

Trummer, Georg, primary, Benk, Christoph, additional, Pooth, Jan Steffen, additional, Brixius, Sam, additional, Haberstroh, Joerg, additional, Damjanovic, Domagoj, additional, Scherer, Christian, additional, and Beyersdorf, Friedhelm, additional

Published
2022
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45. OR19 Visualization of cerebral blood flow in extracorporeal cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest

Author

Pooth, Jan-Steffen, primary, Brixius, Sam, additional, Fostitsch, Johannes, additional, Blazhenets, Ganna, additional, Scherer, Christian, additional, Bretthauer, Berit, additional, Groh, Johannes, additional, Damjanovic, Domagoj, additional, Haberstroh, Jörg, additional, Trummer, Georg, additional, Benk, Christoph, additional, Mix, Michael, additional, Meyer, Philipp, additional, and Beyersdorf, Friedhelm, additional

Published
2022
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46. Cytokine adsorption in patients with post-cardiac arrest syndrome after extracorporeal cardiopulmonary resuscitation (CYTER) - A single-centre, open-label, randomised, controlled trial

Author

Supady, Alexander, Zahn, Timm, Kuhl, Moritz, Maier, Sven, Benk, Christoph, Kaier, Klaus, Boettiger, Bernd W., Bode, Christoph, Lother, Achim, Staudacher, Dawid L., Wengenmayer, Tobias, Duerschmied, Daniel, Supady, Alexander, Zahn, Timm, Kuhl, Moritz, Maier, Sven, Benk, Christoph, Kaier, Klaus, Boettiger, Bernd W., Bode, Christoph, Lother, Achim, Staudacher, Dawid L., Wengenmayer, Tobias, and Duerschmied, Daniel

Abstract

Aim: To investigate the effect of cytokine adsorption in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) after cardiac arrest. Methods: CYTER was a single-centre, open-label, randomised, controlled trial. Patients selected for ECPR at the University Medical Center Freiburg (Freiburg, Germany) were assigned to extracorporeal membrane oxygenation (ECMO) support with or without cytokine adsorption (1:1) using the CytoSorb adsorber, incorporated into the ECMO, replaced every 24 hours, and removed after 72 hours. The primary endpoint was serum interleukin (IL)-6 concentration at 72 hours (intention-to-treat analysis). Secondary endpoints included 30-day survival, vasopressor support and biomarkers of end-organ injury. Results: Of 50 patients enrolled in the trial, 26 (52%) were treated with cytokine adsorption and 24 (48%) without. Nine patients were excluded (informed consent could not be obtained); 41 patients were therefore included in the primary analysis. Median IL-6 levels (IQR) decreased from 408.0 (93.4-906.5) to 324.0 (134.3-4617.3) mu g/mL and increased from 133.0 (56.2-528.5) to 241.0 (132.8-718.0) mu g/mL in the cytokine adsorption and control group, respectively (linear regression for treatment [cytokine adsorption vs control]: p = 0.48). Three (14%) of 22 patients treated with cytokine adsorption and 8 (42%) of 19 patients treated without cytokine adsorption survived to day 30 (HR = 1.85, 95% CI 0.86-4.01; p = 0.10). Vasopressor support and NSE, S100b, troponin T, CRP and PCT levels were similar between groups. Conclusion: Cytokine adsorption in patients receiving ECPR did not reduce serum IL-6 and had no significant effect on survival, vasopressor support, or biomarkers of injury.

Published
2022

48. Limiting calcium overload after cardiac arrest: The role of human albumin in controlled automated reperfusion of the whole body.

Author

Pooth, Jan-Steffen, Brixius, Sam J, Scherer, Christian, Diel, Patric, Liu, Yechi, Taunyane, Itumeleng C, Damjanovic, Domagoj, Wolkewitz, Martin, Haberstroh, Jörg, Benk, Christoph, Trummer, Georg, and Beyersdorf, Friedhelm

Subjects
CALCIUM metabolism, ALBUMINS, IN vitro studies, IN vivo studies, CONFIDENCE intervals, ANIMAL experimentation, MANN Whitney U Test, FISHER exact test, T-test (Statistics), CARDIAC arrest, AUTOMATION, BLOOD plasma substitutes, DESCRIPTIVE statistics, CALCIUM, REPERFUSION, DATA analysis software, ODDS ratio, DISEASE complications
Abstract

Background: Regarding the overall inadequate results after cardiopulmonary resuscitation, the development of new treatment concepts is urgently needed. Controlled Automated Reperfusion of the whoLe body (CARL) represents a therapy bundle to control the conditions of reperfusion and the composition of the reperfusate after cardiac arrest (CA). The aim of this study was to investigate the plasma expander's role in the CARL priming solution and examine its mechanism of action. Methods: Viscosity, osmolality, colloid osmotic pressure (COP), pH and calcium binding of different priming solutions were measured in vitro and compared to in vivo data. N = 16 pigs were allocated to receive CARL following 20 min of untreated CA with either human albumin 20% (HA, N = 8) or gelatin polysuccinate 4% (GP, N = 8). Blood gas analyses were performed during the first hour of reperfusion and catecholamine and fluid requirements were recorded. Neurological outcome was assessed by neurological deficit scoring (NDS) on the seventh day. Results: In vitro, addition of HA to the CARL priming solution resulted in higher COP and higher calcium-binding than GP. In vivo, treatment with HA led to greater reduction of ionized calcium and higher extracorporeal flows within the first 30 min of reperfusion with no difference in catecholamine support and fluid requirement. Seven-day survival of 75% with no difference in NDS was observed in both groups. Conclusions: Our data show that the plasma expander in the CARL priming solution has a significant effect on the initial reperfusate and can potentially influence the course of resuscitation. However, seven-day survival and NDS did not differ between groups. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Enabling the control of reperfusion parameters in out-of-hospital cardiac arrest: First applications of the CARL system.

Author

Philipp, Alois, Pooth, Jan-Steffen, Benk, Christoph, Mueller, Thomas, and Lunz, Dirk

Subjects
CARDIOPULMONARY resuscitation, MYOCARDIAL reperfusion, BLOOD gases analysis, EXTRACORPOREAL membrane oxygenation, CARDIAC arrest, CASE studies, DISCHARGE planning
Abstract

Introduction: There is increasing evidence for extracorporeal cardiopulmonary resuscitation (ECPR) as a rescue therapy for selected patients in refractory cardiac arrest (CA). Besides patient selection, the control of reperfusion parameters is of eminent importance. Especially in out-of-hospital CA, monitoring and individualized, targeted reperfusion remains a great challenge for emergency personnel. The CARL® system is designed to enable an early control of a variety of reperfusion parameters and to pursue a targeted reperfusion strategy in ECPR. Case presentation: We report the first 10 ECPR applications of the CARL® system in Regensburg, Germany. Early blood gas analysis, oxygen titration and pressure monitoring were feasible and enabled an individualized and targeted reperfusion strategy in all patients. After suffering from refractory CA and prolonged resuscitation attempts, five out of the first 10 patients survived and were successfully discharged from the hospital (CPC one on hospital discharge). Conclusion: Application of the CARL® system contributed to early monitoring and control of reperfusion parameters. Whether targeted ECPR may have the potential to improve outcomes in refractory OHCA remains the subject of future investigations. [ABSTRACT FROM AUTHOR]

Published
2023
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