48 results on '"Benjamin Zimmer"'
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2. Among The New Words
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Benjamin Zimmer, Kelly E. Wright, Brianne Hughes, and Charles E. Carson
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Linguistics and Language ,Communication ,Language and Linguistics - Published
- 2022
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3. A methodology for the development of innovation clusters: application in the healthcare sector.
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Benjamin Zimmer, Julie Stal-Le Cardinal, Bernard Yannou, Gilles Le Cardinal, François Piette, and Vincent Boly
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- 2014
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4. Hemodynamic cortical ripples through cyclicity analysis
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Ivan Abraham, Somayeh Shahsavarani, Benjamin Zimmerman, Fatima T. Husain, and Yuliy Baryshnikov
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Electronic computers. Computer science ,QA75.5-76.95 - Published
- 2024
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5. Neurovascular mechanisms of cognitive aging: Sex-related differences in the average progression of arteriosclerosis, white matter atrophy, and cognitive decline
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Daniel C. Bowie, Kathy A. Low, Samantha L. Rubenstein, Samia S. Islam, Benjamin Zimmerman, Paul B. Camacho, Bradley P. Sutton, Gabriele Gratton, and Monica Fabiani
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Cognitive aging ,Cerebrovascular health ,Cerebral arterial pulse based on diffused optical tomography (pulse-DOT) ,Arteriosclerosis ,White matter lesions ,Sex differences ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Arterial stiffness (arteriosclerosis) has been linked to heightened risks for cognitive decline, and ultimately for Alzheimer's disease and other forms of dementia. Importantly, neurovascular outcomes generally vary according to one's biological sex. Here, capitalizing on a large sample of participants with neuroimaging and behavioral data (N = 203, age range = 18–87 years), we aimed to provide support for a hierarchical model of neurocognitive aging, which links age-related declines in cerebrovascular health to the rate of cognitive decline via a series of intervening variables, such as white matter integrity. By applying a novel piecewise regression approach to our cross-sectional sample to support Granger-like temporal inferences, we show that, on average, a precipitous decline in cerebral arterial elasticity (measured with diffuse optical imaging of the cerebral arterial pulse; pulse-DOT) precedes an acceleration in the development of white matter lesions by nearly a decade, with women protected from these deleterious effects until approximately age 50, the average onset of menopause. By employing multiple-mediator path analyses while controlling for sex, we show that age may impair cognition via the sequential indirect effects of arteriosclerosis and white matter atrophy on fluid, but not crystallized, abilities. Importantly, we replicate these results using pulse pressure, an independent index of arterial health, thereby providing converging evidence for the central role of arteriosclerosis as an accelerating factor in normal and pathological aging and identifying robust sex-related differences in the progression of cerebral arteriosclerosis and white matter degradation.
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- 2024
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6. 'Among the New Words': The Prospects and Challenges of Short-Term Historical Lexicography
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Benjamin Zimmer and Charles E. Carson
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060201 languages & linguistics ,Linguistics and Language ,History ,Inclusion (disability rights) ,Communication ,Perspective (graphical) ,06 humanities and the arts ,Language and Linguistics ,Lexical item ,Linguistics ,Term (time) ,Feature (linguistics) ,Documentary evidence ,Documentation ,0602 languages and literature ,Neologism - Abstract
Historical lexicography as practiced in the manner of the Oxford English Dictionary typically takes the long view, requiring the gradual accumulation of a substantial depth of documentary evidence for a particular lexical item before it is considered for potential inclusion. But for nearly eight decades, a continuing project in historical lexicography has concentrated on items with decidedly short-term history. "Among the New Words," a feature established by Dwight Bolinger in the pages of American Speech, has applied an OED-style approach to the documentation of neologisms. In this article, two of the current editors of "Among the New Words" look back at the feature's history in order to provide some perspective on the new prospects and challenges of engaging in short-term historical lexicography.
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- 2018
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7. Among the New Words
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Benjamin Zimmer, Jane Solomon, Charles E. Carson, and Donna M. Farina
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Linguistics and Language ,Communication ,Language and Linguistics - Published
- 2017
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8. CBT4BN: A Randomized Controlled Trial of Online Chat and Face-to-Face Group Therapy for Bulimia Nervosa
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Robert M. Hamer, Marsha D. Marcus, Hans Kordy, Cynthia M. Bulik, Michele D. Levine, Sara M. Hofmeier, Jennifer R. Shapiro, Cristin D. Runfola, Hunna J. Watson, Christine M. Peat, Markus Moessner, Benjamin Zimmer, Stephanie Zerwas, and Ross D. Crosby
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Male ,050103 clinical psychology ,medicine.medical_specialty ,Online chat ,Psychotherapist ,Evidence-based practice ,medicine.medical_treatment ,Article ,law.invention ,Group psychotherapy ,03 medical and health sciences ,Face-to-face ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,0501 psychology and cognitive sciences ,Bulimia Nervosa ,Psychiatry ,Applied Psychology ,Internet ,Cognitive Behavioral Therapy ,Bulimia nervosa ,05 social sciences ,General Medicine ,medicine.disease ,Telemedicine ,030227 psychiatry ,Cognitive behavioral therapy ,Psychiatry and Mental health ,Clinical Psychology ,Treatment Outcome ,Psychotherapy, Group ,Cognitive therapy ,Female ,Psychology - Abstract
Objective: Although cognitive-behavioral therapy (CBT) represents the first-line evidence-based psychotherapy for bulimia nervosa (BN), most individuals seeking treatment do not have access to this specialized intervention. We compared an Internet-based manualized version of CBT group therapy for BN conducted via a therapeutic chat group (CBT4BN) to the same treatment conducted via a traditional face-to-face group therapy (CBTF2F). Method: In a two-site, randomized, controlled noninferiority trial, we tested the hypothesis that CBT4BN would not be inferior to CBTF2F. A total of 179 adult patients with BN (2.6% males) received up to 16 sessions of group CBT over 20 weeks in either CBT4BN or CBTF2F, and outcomes were compared at the end of treatment and at the 12-month follow-up. Results: At the end of treatment, CBT4BN was inferior to CBTF2F in producing abstinence from binge eating and purging. However, by the 12-month follow-up, CBT4BN was mostly not inferior to CBTF2F. Participants in the CBT4BN condition, but not CBTF2F, continued to reduce their binge-eating and purging frequency from the end of treatment to the 12-month follow-up. Conclusions: CBT delivered online in a group chat format appears to be an efficacious treatment for BN, although the trajectory of recovery may be slower than face-to-face group therapy. Online chat groups may increase accessibility of treatment and represent a cost-effective approach to service delivery. However, barriers in service delivery such as state-specific license and ethical guidelines for online therapists need to be addressed.
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- 2016
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9. Seventy-Five Years among the New Words
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Jane Solomon, Benjamin Zimmer, and Charles E. Carson
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Linguistics and Language ,History ,Communication ,Language and Linguistics - Abstract
In celebration of the 75th anniversary of American Speech's regular feature “Among the New Words,” the current editors briefly recount the column's history and then highlight some of the words treated therein. A notable word from each year since 1941 was selected from the published treatments for further reflection and reevaluation. The words treated here not only demonstrate the evolving nature of the English language, but also reflect historical events, societal changes, and technological developments from the last three-quarters of a century, starting in the midst of World War II and ending in the rise of the information Age and social media.
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- 2016
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10. The UNPC innovativeness set of indicators for idea or project selection and maturation in healthcare
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Alborz Bekhradi, Bernard Yannou, François Cluzel, Romain Farel, Benjamin Zimmer, Laboratoire Génie Industriel - EA 2606 (LGI), CentraleSupélec, Paris Saclay Efficacité Energétique (PS2E), and Silver Valley
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idea maturity ,innovation process ,[SPI.OTHER]Engineering Sciences [physics]/Other ,innovativeness indicators ,0209 industrial biotechnology ,Engineering ,Knowledge management ,Cognitive Neuroscience ,Project selection ,0211 other engineering and technologies ,Experimental and Cognitive Psychology ,02 engineering and technology ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,Behavioral Neuroscience ,020901 industrial engineering & automation ,Health care ,Marketing ,Set (psychology) ,maturity monitoring ,ideation indicators ,021106 design practice & management ,Innovation competition ,business.industry ,Innovation process ,innovation competition ,[INFO.INFO-IA]Computer Science [cs]/Computer Aided Engineering ,Ideation ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,idea selection ,Work (electrical) ,Idea selection ,business - Abstract
International audience; A great deal of work has been done to characterize entire sets of ideation indicators as well as isolated factors of innovativeness. Nevertheless, entire sets of innovativeness indicators are essential in business innovation competitions, as well as within companies in order to select promising innovation seeds. In this paper, a complete set of innovativeness indicators in the context of innovating in healthcare is proposed. The UNPC innovativeness model, standing for usefulness, newness, profitability and (proof of) concept, has been tested and validated over a period of 4 years within the largest European innovation cluster in the silver economy. Four authentic examples of innovation selections are analysed. They illustrate how the UNPC model is able to provide clear and efficient guidance for better decision-making in the context of innovating for the elderly. In addition, a framework for monitoring an innovative idea or project, and for increasing its maturity, is proposed. The UNPC monitoring process starts with the SWOT analysis of competing ideas. It then becomes dynamic, looking for new evidence for increasing the certainty and impact of UNPC proofs of the competing ideas. The model has been successfully used for upgrading a popular smart application on activity tracking.
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- 2016
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11. Start-up, arrêtons la mascarade
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Nicolas Menet, Benjamin Zimmer, Nicolas Menet, and Benjamin Zimmer
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Startup! Voilà un mot qui fait rêver des générations entières, dans le monde entier. Argent, richesse, gloire pour certains, innovation, progrès, mission messianique pour d'autres, la startup est le lieu de presque toutes les nouvelles utopies. Mais, problème... des millions d'euros d'argent public subventionnent cet « écosystème » sans retour sur investissement. Derrière le rêve, se cache une réalité plus rude. Il est temps d'imaginer un vrai projet de société autour de cette nouvelle manière de créer de la valeur.Ce livre déconstruit le mythe du startuper et propose un nouveau modèle, plus mature et plus adapté aux enjeux des prochaines années. Il s'adresse aux entrepreneurs, aux startupers, aux investisseurs et aux dirigeants de l'innovation, issus de la sphère privée ou publique, et à tous ceux qui se passionnent pour le temps présent et le monde qui vient.Faisons de la startup un projet de société plutôt qu'un phénomène sociétal!
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- 2018
12. AMONG THE NEW WORDS
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Benjamin Zimmer, Jane Solomon, and Charles E. Carson
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Linguistics and Language ,Communication ,Language and Linguistics - Published
- 2015
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13. The core symptoms of bulimia nervosa, anxiety, and depression: A network analysis
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Cheri A. Levinson, Benjamin J. Calebs, Markus Moesner, Michele D. Levine, Stephanie Zerwas, Kelsie T. Forbush, Cynthia M. Bulik, Marsha D. Marcus, Sara M. Hofmeier, Hunna J. Watson, Christine M. Peat, Hans Kordy, Cristin D. Runfola, Benjamin Zimmer, and Ross D. Crosby
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Adult ,Male ,050103 clinical psychology ,medicine.medical_specialty ,Adolescent ,Psychological intervention ,Poison control ,Anxiety ,Models, Psychological ,Weight Gain ,Article ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Injury prevention ,medicine ,Humans ,0501 psychology and cognitive sciences ,Psychiatry ,Bulimia Nervosa ,Biological Psychiatry ,Depression (differential diagnoses) ,Aged ,Binge eating ,Bulimia nervosa ,Depression ,05 social sciences ,Fear ,Middle Aged ,medicine.disease ,030227 psychiatry ,Clinical Psychology ,Psychiatry and Mental health ,Data Interpretation, Statistical ,Female ,medicine.symptom ,Psychology ,Clinical psychology ,Psychopathology - Abstract
Bulimia nervosa (BN) is characterized by symptoms of binge eating and compensatory behavior, and overevaluation of weight and shape, which often co-occur with symptoms of anxiety and depression. However, there is little research identifying which specific BN symptoms maintain BN psychopathology and how they are associated with symptoms of depression and anxiety. Network analyses represent an emerging method in psychopathology research to examine how symptoms interact and may become self-reinforcing. In the current study of adults with a Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition (DSM-IV) diagnosis of BN (N = 196), we used network analysis to identify the central symptoms of BN, as well as symptoms that may bridge the association between BN symptoms and anxiety and depression symptoms. Results showed that fear of weight gain was central to BN psychopathology, whereas binge eating, purging, and restriction were less central in the symptom network. Symptoms related to sensitivity to physical sensations (e.g., changes in appetite, feeling dizzy, and wobbly) were identified as bridge symptoms between BN, and anxiety and depressive symptoms. We discuss our findings with respect to cognitive-behavioral treatment approaches for BN. These findings suggest that treatments for BN should focus on fear of weight gain, perhaps through exposure therapies. Further, interventions focusing on exposure to physical sensations may also address BN psychopathology, as well as co-occurring anxiety and depressive symptoms. (PsycINFO Database Record
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- 2017
14. Cost-effectiveness of an Internet-based aftercare intervention after inpatient treatment in a psychosomatic hospital
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Hans Kordy, Stephanie Bauer, Fikret Ozer, Benjamin Zimmer, Markus Wolf, and Markus Moessner
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Adult ,Male ,Comparative Effectiveness Research ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,Comparative effectiveness research ,Psychological intervention ,Aftercare ,Treatment as usual ,Psychosomatic Medicine ,Internet based ,Intervention (counseling) ,medicine ,Humans ,health care economics and organizations ,Internet ,Cost–benefit analysis ,business.industry ,Mental Disorders ,Psychosomatic medicine ,Middle Aged ,Hospitalization ,Clinical Psychology ,Physical therapy ,Female ,business - Abstract
Objective: The implementation of new interventions into routine care requires the demonstration of both their effectiveness and cost-effectiveness. Method: We explored the cost-effectiveness of an Internet-based aftercare program in addition to treatment as usual (CHAT) which was compared to treatment as usual (TAU) following inpatient treatment. Incremental cost-effectiveness ratios were calculated based on cost of the intervention, cost of outpatient treatment, and remission rates within 1 year after discharge from hospital. Results: Assuming a willingness-to-pay of an additional 14.87 € per treatment for every additional percent of remission, CHAT was cost-effective against TAU at a 95% level of certainty. Cost per remission equaled 2664.84 € in TAU and 1752.75 € in CHAT (34.2% savings). Conclusions: This is the first evidence that Internet-based aftercare may enhance long-term treatment outcome in a cost-effective way.
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- 2013
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15. Prozess-Ergebnis-Zusammenhänge einer internetbasierten Vorbereitung auf eine stationäre psychosomatische Behandlung: Eine Analyse des Nutzungsverhaltens
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Benjamin Zimmer
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Gynecology ,Psychiatry and Mental health ,medicine.medical_specialty ,Self help groups ,Political science ,Treatment outcome ,medicine ,Text messaging - Abstract
Ziel der Studie: Zentral fur die Uberprufung internetbasierter Interventionen ist die Analyse der Webseitennutzung. Methodik: Es werden Daten einer internetbasierten Vorbereitung auf einen stationaren psychotherapeutischen Aufenthalt analysiert. Ergebnisse: Es zeigen sich grose Unterschiede zwischen den Teilnehmern bezuglich der Webseitennutzung. Unterschiede in den Erfolgsquoten ergaben sich jedoch zwischen den a priori definierten Nutzerprofilen nicht. Schlussfolgerung: Offen gestaltete E-Health-Angebote ermoglichen es den Teilnehmern, diese ihren Bedurfnissen entsprechend zu nutzen.
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- 2013
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16. Among the New Words
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Benjamin Zimmer and Charles E. Carson
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Linguistics and Language ,Communication ,Language and Linguistics - Published
- 2013
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17. P4‐001: A Large, Randomized, Double‐Blind, Placebo‐Controlled Study Evaluating RVT‐101, A Neurotransmitter‐Targeted Therapy, in Subjects with Mild‐to‐Moderate Alzheimer's Disease on Donepezil Treatment: Phase 3 Mindset Study Design
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Shari Coslett, Lawrence T. Friedhoff, Kunal Kishnani, Benjamin Zimmer, David W. Liu, and Ilise Lombardo
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medicine.medical_specialty ,Psychotherapist ,Epidemiology ,Health Policy ,medicine.medical_treatment ,Placebo-controlled study ,Mindset ,Disease ,Targeted therapy ,Double blind ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Developmental Neuroscience ,chemistry ,Internal medicine ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,Donepezil ,Psychology ,Neurotransmitter ,medicine.drug - Published
- 2016
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18. CBT4BN versus CBTF2F: Comparison of online versus face-to-face treatment for bulimia nervosa
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Benjamin Zimmer, Cynthia M. Bulik, Sara E. Trace, Stephanie Zerwas, Sara M. Hofmeier, Robert M. Hamer, Marsha D. Marcus, Markus Moessner, Hans Kordy, and Michele D. Levine
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medicine.medical_specialty ,Cost-Benefit Analysis ,medicine.medical_treatment ,behavioral disciplines and activities ,Article ,law.invention ,Randomized controlled trial ,Quality of life ,law ,mental disorders ,medicine ,Humans ,Multicenter Studies as Topic ,Pharmacology (medical) ,Bulimia Nervosa ,Psychiatry ,Randomized Controlled Trials as Topic ,Internet ,Psychological Tests ,Cognitive Behavioral Therapy ,Bulimia nervosa ,business.industry ,Gold standard ,General Medicine ,medicine.disease ,Cognitive behavioral therapy ,Clinical trial ,Eating disorders ,Psychotherapy, Group ,Quality of Life ,Cognitive therapy ,Physical therapy ,business - Abstract
Cognitive-behavioral therapy (CBT) is currently the “gold standard” for treatment of bulimia nervosa (BN), and is effective for approximately 40–60% of individuals receiving treatment; however, the majority of individuals in need of care do not have access to CBT. New strategies for service delivery of CBT and for maximizing maintenance of treatment benefits are critical for improving our ability to treat BN. This clinical trial is comparing an Internet-based version of CBT (CBT4BN) in which group intervention is conducted via therapeutic chat group with traditional group CBT (CBTF2F) for BN conducted via face-to-face therapy group. The purpose of the trial is to determine whether manualized CBT delivered via the Internet is not inferior to the gold standard of manualized group CBT. In this two-site randomized controlled trial, powered for non-inferiority analyses, 180 individuals with BN are being randomized to either CBT4BN or CBTF2F. We hypothesize that CBT4BN will not be inferior to CBTF2F and that participants will value the convenience of an online intervention. If not inferior, CBT4BN may be a cost-effective approach to service delivery for individuals requiring treatment for BN.
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- 2012
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19. Among the New Words
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Benjamin Zimmer and Charles E. Carson
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Linguistics and Language ,Communication ,Language and Linguistics - Published
- 2012
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20. Therapieevaluation in der stationären Psychotherapie mit Web-AKQUASI
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Benjamin Zimmer and Markus Moessner
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Fur die allgemeine Definition des Qualitatsbegriffs im Gesundheitswesen war das Phasenmodell der Qualitat nach Donabedian (1966) wegweisend, da er als erster Qualitatsforscher sein Konzept auf medizinische Leistungen ubertrug. Es erfasst Qualitat auf den drei Dimensionen Struktur-, Prozess-, und Ergebnisqualitat. Die Strukturqualitat fasst dabei alle notwendigen Voraussetzungen zur Leistungserbringung zusammen. Die Prozessqualitat bezieht sich auf die Gesamtheit aller Aktivitaten wahrend des therapeutischen Prozesses und die Ergebnisqualitat erfasst den erzielten Therapieerfolg durch die umgesetzten Therapiemasnahmen. Da das Therapieergebnis Ziel aller Strukturen und Prozesse der therapeutischen Behandlung ist, wird die Ergebnisqualitat als wichtigster Qualitatsaspekt beurteilt und ist daher Schwerpunkt vieler Modelle der QS. Hauptziel ist damit die kontinuierliche Verbesserung der angebotenen Versorgung. Ein universelles Modell zur Qualitatsverbesserung ist der PDCA-Zyklus nach Deming der einen fortwahrenden dynamischen Prozess folgender Aktionen beschreibt (siehe Weigert 2008)
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- 2012
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21. Internetbasierte Vorbereitung auf eine stationäre psychosomatisch-psychotherapeutische Behandlung
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Hans Kordy, Benjamin Zimmer, and Christian Peter Dogs
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Gynecology ,Clinical Psychology ,medicine.medical_specialty ,business.industry ,Medicine ,business - Abstract
In dieser Studie wurde das in der nachstationaren Betreuung bewahrte Konzept internetbasierter Minimalinterventionen auf die Phase der vorstationaren Wartezeit angepasst. Das Programm umfasst einen Informations-, einen Motivations-, einen Unterstutzungs- und einen Kontaktbereich. Als Studiendesign wurde ein „comprehensive cohort design“ mit 379 Patienten in der randomisierten Studiengruppe umgesetzt. Zielkriterien der Studie waren die Veranderungsgeschwindigkeit der korperlichen, psychischen und sozialen Beeintrachtigung sowie des psychologischen Wohlbefindens innerhalb der ersten 2 stationaren Behandlungswochen und der Anteil reliabler Verbesserungen 2 Wochen nach Behandlungsbeginn. In der randomisierten Studiengruppe zeigen sowohl die Teilnehmer der Interventionsgruppe (IG) als auch die der Kontrollgruppe (KG) in den ersten beiden Wochen nach Aufnahme eine statistisch signifikante Verbesserung des Gesundheitszustands. Es findet sich kein signifikanter Unterschied in der Veranderungsgeschwindigkeit beider Gruppen. Dabei entspricht das Ausmas der erreichten Verbesserung im korperlichen Zustand dem erwarteten Interventionseffekt. Ein Unterschied in den Veranderungsraten ergibt sich nur fur das psychologische Wohlbefinden: Hier zeigt die IG um 19% mehr reliable Verbesserungen. Das Studiendesign und die Inhalte der vorstationaren Betreuung werden von den Patienten angenommen. Das internetbasierte Angebot hilft den auf die stationare Behandlung wartenden Patienten, sich auf die Behandlung vorzubereiten und sich in der Klinik schneller auf die Therapie einzulassen.
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- 2011
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22. Die Kommunikation von Patienten mit einer chronischen Erkrankung in einem Internet-Chat zur Nachsorge einer stationären psychosomatischen Behandlung
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Hans Kordy, Markus Moessner, and Benjamin Zimmer
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medicine.medical_specialty ,Sick role ,business.industry ,medicine.medical_treatment ,Rehabilitation ,MEDLINE ,Cognition ,Group psychotherapy ,Patient satisfaction ,Chronic disease ,Ambulatory care ,medicine ,Psychiatry ,Internet chat ,business - Abstract
Aim E-Health applications open new avenues for seamless care of patients with a chronic disease. This study examines the demand and the usage pattern of an Internet-assisted aftercare group-treatment following inpatient treatment. Methods The analysis uses data from telephone interviews which were conducted 12 months after discharge. 168 study participants of the prospective controlled effectiveness study (73.7%) participated. The frequency and the time of beginning an outpatient psychotherapy are compared between controls and chat participants. Computerized text-analyses of the chat-scripts are used to examine the usage pattern of the chat-aftercare. Statements of the patients with chronic symptoms at the beginning and at the end of their chat participation are quoted for illustration of the contents of the group therapy sessions. Results Patients with chronic course of illness utilize the online-based aftercare more frequently and more actively than patients with short durations of illness. Words indicating cognitive processes are used more frequently by chat participant with chronic illness. Chat participants with chronic course of illness who are receiving no additional outpatient psychotherapy, relapse considerably less frequently than controls without any psychotherapeutic support. Conclusion Patients with chronic course of illness use online aftercare treatment to sustainably improve their health status.
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- 2010
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23. Cost-Effectiveness of Internet-Based Cognitive-Behavioral Treatment for Bulimia Nervosa
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Stephanie Zerwas, Markus Moessner, Christine M. Peat, Cristin D. Runfola, Michele D. Levine, Hunna J. Watson, Cynthia M. Bulik, Sara M. Hofmeier, Ross D. Crosby, Scott J. Crow, Benjamin Zimmer, Nicole B. McLagan, Marsha D. Marcus, and Robert M. Hamer
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Adult ,Male ,050103 clinical psychology ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,media_common.quotation_subject ,Population ,Article ,law.invention ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Binge-eating disorder ,law ,medicine ,Humans ,0501 psychology and cognitive sciences ,Bulimia Nervosa ,education ,health care economics and organizations ,media_common ,Internet ,education.field_of_study ,Cognitive Behavioral Therapy ,Binge eating ,Bulimia nervosa ,business.industry ,05 social sciences ,Health Care Costs ,Abstinence ,medicine.disease ,Telemedicine ,030227 psychiatry ,Clinical trial ,Psychiatry and Mental health ,Treatment Outcome ,Psychotherapy, Group ,Physical therapy ,Female ,Quality-Adjusted Life Years ,medicine.symptom ,business - Abstract
Objective To evaluate the cost-effectiveness of Internet-based cognitive-behavioral therapy for bulimia nervosa (CBT-BN) compared to face-to-face delivery of CBT-BN. Methods This study is a planned secondary analysis of data from a randomized clinical trial. Participants were 179 adults (98% female, mean age = 28 years) meeting DSM-IV criteria for bulimia nervosa who were randomized to group face-to-face or group Internet-based CBT-BN for 16 sessions during 20 weeks. The cost-effectiveness analysis was conducted from a third-party payor perspective, and a partial societal perspective analysis was conducted to investigate cost-utility (ie, cost per gain in quality-adjusted life-years) and patient out-of-pocket travel-related costs. Net health care costs were calculated from protocol and nonprotocol health care services using third-party payor cost estimates. The primary outcome measure in the clinical trial was abstinence from binge eating and purging, and the trial start and end dates were 2008 and 2016. Results The mean cost per abstinent patient at posttreatment was $7,757 (95% confidence limit [CL], $4,515, $13,361) for face-to-face and $11,870 (95% CL, $6,486, $22,188) for Internet-based CBT-BN, and at 1-year follow-up was $16,777 (95% CL, $10,298, $27,042) for face-to-face and $14,561 (95% CL, $10,165, $21,028) for Internet-based CBT-BN. There were no statistically significant differences between treatment arms in cost-effectiveness or cost-utility at posttreatment or 1-year follow-up. Out-of-pocket patient costs were significantly higher for face-to-face (mean [95% CL] = $178 [$127, $140]) than Internet-based ($50 [$50, $50]) therapy. Conclusions Third-party payor cost-effectiveness of Internet-based CBT-BN is comparable with that of an accepted standard. Internet-based dissemination of CBT-BN may be a viable alternative for patients geographically distant from specialist eating disorder services who have an unmet need for treatment. Trial registration ClinicalTrials.gov identifier: NCT00877786.
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- 2018
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24. New media for the health care
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Stephanie Bauer, Markus Wolf, Benjamin Zimmer, and Markus Moessner
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Clinical Psychology ,Political science ,Humanities - Abstract
Die rasante Entwicklung von Informations- und Kommunikationstechnologien sowie deren Verfugbarkeit in weiten Teilen der Bevolkerung bieten groses Potenzial fur die gesundheitliche Versorgung. Im Internet bereitgestellte Informationen eroffnen neue Moglichkeiten der Kompetenzvermittlung und konnen damit zu einer Starkung der partizipativen Nutzung des Gesundheitswesens beitragen. Neben Auswirkungen neuer Medien auf das Nutzer- und Inanspruchnahmeverhalten machen sich zahlreiche Versorgungsangebote die Vorteile moderner Technologien auf innovative Weise zunutze. Die Einsatzmoglichkeiten sind dabei keinesfalls auf spezifische Bereiche beschrankt, sondern erstrecken sich uber das gesamte Spektrum psychosozialer Versorgungsangebote. Dank der spezifischen Eigenschaften neuer Medien konnen Versorgungslucken erfolgreich gefullt werden.
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- 2008
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25. Usefulness Simulation of Design Concepts
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Benjamin Zimmer, Romain Farel, Bernard Yannou, Jeya Chandra, Alborz Bekhradi, Laboratoire Génie Industriel - EA 2606 (LGI), CentraleSupélec, Silver Valley, Pennsylvania State University (Penn State), and Penn State System
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Service (systems architecture) ,Engineering ,usage scenarios coverage ,Elderly falls ,Space (commercial competition) ,Task (project management) ,[SPI]Engineering Sciences [physics] ,Order (exchange) ,Utilitarianism ,design evaluation ,usefulness ,business.industry ,Mechanical Engineering ,[INFO.INFO-CE]Computer Science [cs]/Computational Engineering, Finance, and Science [cs.CE] ,Perspective (graphical) ,[INFO.INFO-IA]Computer Science [cs]/Computer Aided Engineering ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,Computer Graphics and Computer-Aided Design ,usage simulation ,Computer Science Applications ,Product (business) ,Risk analysis (engineering) ,Mechanics of Materials ,design performance simulation ,Systems engineering ,business - Abstract
International audience; Usefulness, from the utilitarianism perspective, is the ability of a product or service to improve the well-being of humans and to minimize their suffering in different situations. In the case of the widespread issue of falls among the elderly, designing an adapted solution to is not an obvious task. The latter requires quantifying various usage scenarios. The usage scenarios, or segments, associated with elderly falls must be investigated to ensure that newly designed products and services are likely to bring essential health, social and economic values. Optimizing a design solution by considering the coverage of such usage segments extends the classical methods of design for market approaches. Starting from a disparate literature on elderly falls' issue, we have first built a usage scenarios space. Next, the usefulness and the coverage ability of three design solutions are evaluated over a tessellation of usage segments. In addition, the developed usage simulator is used to assess the potential of non or poorly-covered usage segments to deliver insightful information in order to truly be a need seeker in the front-end of innovation.
- Published
- 2015
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26. Effectiveness of an Internet-based preparation for psychosomatic treatment: results of a controlled observational study
- Author
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Stephanie Bauer, Markus Wolf, Sally Kindermann, Benjamin Zimmer, Carla Minarik, Markus Moessner, University of Zurich, and Zimmer, Benjamin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Social Problems ,Waiting Lists ,Treatment outcome ,Effectiveness ,Treatment results ,law.invention ,2738 Psychiatry and Mental Health ,Randomized controlled trial ,Internet based ,law ,Medicine ,Humans ,Prospective Studies ,based intervention ,Propensity Score ,Aged ,Internet ,Treatment preparation ,Consumer Health Information ,business.industry ,10093 Institute of Psychology ,Confounding ,3203 Clinical Psychology ,Middle Aged ,Patient Acceptance of Health Care ,Psychophysiologic Disorders ,Psychotherapy ,Mental healthcare ,Psychiatry and Mental health ,Clinical Psychology ,Treatment Outcome ,Socioeconomic Factors ,Implementation ,Propensity score matching ,Physical therapy ,Treatment motivation ,Observational study ,Female ,business ,150 Psychology ,Clinical psychology - Abstract
Objective Patients often have to sustain long waiting periods between the time they first apply for psychotherapy and the actual uptake of the treatment. To support patients who are on a wait-list for inpatient psychosomatic treatment an Internet-based preparatory treatment (VORSTAT) was developed. In a randomized controlled trial, VORSTAT proved to increase treatment motivation prior to intake and to accelerate the accommodation phase at the beginning of inpatient treatment. No impact of VORSTAT on inpatient treatment outcome was found. The aim of the present study was to investigate the effectiveness of VORSTAT after implementing the service into routine care. Methods A large naturalistic observational study comparing VORSTAT participants (N = 911) against non-participants (N = 1721) was conducted. Propensity scores were used to control for potential confounding variables due to the non-randomized group allocation. Reliable improvement of self-reported impairment achieved during inpatient treatment was used as outcome measure. Results VORSTAT participants showed higher rates of reliable improvement in physical impairment (50.8% vs. 44.9%), psychological impairment (41.2% vs. 29.9%), and social problems (22.3% vs. 15.2%). Conclusion An Internet-based preparation for psychotherapy is an effective approach to improve outcome of inpatient psychosomatic treatment.
- Published
- 2015
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27. Sélectionner et accompagner votre projet d’innovation à l’aide de SAPIGE®
- Author
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Benjamin Zimmer
- Abstract
Vous etes un professionnel du management de l’innovation qui avez ete confronte a des difficultes pour detecter, selectionner et/ou accompagner un projet d’innovation au sein de votre structure. Placons-nous d’emblee dans le cadre d’une idee ou d’un projet de developpement d’un produit (ou service) innovant. En effet, nous trouvons dans trois cas differents cette problematique de detection, selection et accompagnement de l’innovation : en interne d’une entreprise pour le processus de selection et de developpement d’idees en amont des projets de RD en open innovation dans les concours de projets innovants ou bien en entreprise etendue lorsque plusieurs entreprises s’associent au sein de clusters d’innovation ou de grappes d’entreprise pour favoriser et controler le developpement d’innovations dans un secteur technologique, industriel, social ou marketing emergent ( Zimmer, 2012 ) ; chez des organismes financeurs de l’innovation : chambres de commerce, centres d’innovation regionaux ou nationaux, incubateurs, financeurs prives ( business angels , societe de gestion de capital risque), fondations privees, etc. Cette fiche a pour ambition de vous presenter des points de reperes pour professionnaliser votre selection et l’accompagnement de vos projets d’innovation. Elle presente pas a pas l’outil SAPIGE®. Il permet au professionnel du management de l’innovation de se familiariser avec un outil qui pourra l’aider a organiser la selection et a diminuer les risques de developper un projet d’innovation insuffisamment createur de valeur pour son ecosysteme.
- Published
- 2014
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28. Participer à un cluster d’innovation : une opportunité pour l’entreprise
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Benjamin Zimmer
- Abstract
En plein essor, car fortement encourages par les pouvoirs publics, les clusters d’innovation sont des structures, generalement associatives, regroupant l’ensemble des acteurs d’une chaine de valeurs d’un marche existant ou en devenir. Ces clusters d’innovation sont : des ecosystemes propices a la competitivite, au developpement d’opportunites d’affaires ; des lieux de brainstorming, de mutualisation des ressources et potentiels de ses membres ; des lieux de rencontre, d’ecoute et de partage de connaissances et competences d’un marche. Certains clusters d’innovation ont pour finalite de faire emerger et d’accompagner des innovations de produits, de services ou d’organisation pour creer de la valeur pour ses membres et, plus globalement, pour une filiere industrielle. Cette fiche s’adresse aux acteurs, et particulierement aux entrepreneurs, qui n’ont pas encore pris la decision d’adherer a l’une de ces structures. Elle vous aidera a identifier les benefices, les risques et les couts lies a votre participation dans le developpement des activites de ces clusters. Elle vous presente les principaux objectifs et fonctions de services que ces structures mettent a votre disposition de maniere collective et personnalisee pour accelerer la transformation d’une bonne idee en un prototype, puis dans un lancement commercial reussi du produit.
- Published
- 2014
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29. Enjeux et opportunités de la filière Silver économie : exemple de la France
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Benjamin Zimmer
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Abstract
Récapitulation. La Silver économie rassemble l’ensemble des acteurs producteurs de biens et/ou de services qui répondent aux besoins et aux usages des seniors et de leur entourage. C’est une filière transversale qui regroupe de nombreux secteurs d’activité allant de la santé en passant par la construction, les services, le cosmétique, la communication jusqu’au transport ou les loisirs, etc. et qui vise à créer de la valeur économique, sociale et sociétale. Cette approche économique du vieillissement présente de fortes opportunités de croissance, de production et d’emploi et est affichée comme une filière industrielle prioritaire par les pouvoirs publics.
- Published
- 2016
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30. Herausforderungen und Chancen der 'Silver Economy' – Beispiel Frankreich
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Benjamin Zimmer
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Abstract
Zusammenfassung. Die Silver Economy umfasst alle Warenhersteller und/oder Dienstleister, die die Bedürfnisse von Senioren und ihrem Umfeld erfüllen. Sie ist branchenübergreifend mit zahlreichen Tätigkeitsfeldern – von der Gesundheit über den Baubereich, Dienstleistungen, Kosmetik und Kommunikation bis hin zu Transport oder Freizeit usw. – und hat die Schaffung eines ökonomischen, sozialen und gesellschaftlichen Mehrwerts zum Ziel. Dieses auf Senioren bezogene wirtschaftliche Konzept verspricht große Chancen für Wachstum, Produktion und Beschäftigung und wird von öffentlichen Stellen als eine bevorzugte Industriebranche präsentiert.
- Published
- 2016
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31. Apolipoprotein E levels in the amygdala and prefrontal cortex predict relative regional brain volumes in irradiated Rhesus macaques
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Payel Kundu, Benjamin Zimmerman, Ruby Perez, Christopher T. Whitlow, J. Mark Cline, John D. Olson, Rachel N. Andrews, and Jacob Raber
- Subjects
Medicine ,Science - Abstract
Abstract In the brain, apolipoprotein E (apoE) plays an important role in lipid transport and response to environmental and age-related challenges, including neuronal repair following injury. While much has been learned from radiation studies in rodents, a gap in our knowledge is how radiation might affect the brain in primates. This is important for assessing risk to the brain following radiotherapy as part of cancer treatment or environmental radiation exposure as part of a nuclear accident, bioterrorism, or a nuclear attack. In this study, we investigated the effects of ionizing radiation on brain volumes and apoE levels in the prefrontal cortex, amygdala, and hippocampus of Rhesus macaques that were part of the Nonhuman Primate Radiation Survivor Cohort at the Wake Forest University. This unique cohort is composed of Rhesus macaques that had previously received single total body doses of 6.5–8.05 Gy of ionizing radiation. Regional apoE levels predicted regional volume in the amygdala and the prefrontal cortex. In addition, apoE levels in the amygdala, but not the hippocampus, strongly predicted relative hippocampal volume. Finally, radiation dose negatively affected relative hippocampal volume when apoE levels in the amygdala were controlled for, suggesting a protective compensatory role of regional apoE levels following radiation exposure. In a supplementary analysis, there also was a robust positive relationship between the neuroprotective protein α-klotho and apoE levels in the amygdala, further supporting the potentially protective role of apoE. Increased understanding of the effects of IR in the primate brain and the role of apoE in the irradiated brain could inform future therapies to mitigate the adverse effects of IR on the CNS.
- Published
- 2021
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32. A methodology for the development of innovation clusters: application in the health care sector
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Bernard Yannou, François Piette, Gilles Le Cardinal, Benjamin Zimmer, Vincent Boly, Julie Stal-Le Cardinal, Computer Science Department, Linnaeus University, Laboratoire Génie Industriel - EA 2606 (LGI), CentraleSupélec, Ecole Centrale Paris, Université de Technologie de Compiègne (UTC), Université Pierre et Marie Curie - Paris 6 (UPMC), Equipe de Recherche sur les Processus Innovatifs (ERPI), and Université de Lorraine (UL)
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Knowledge management ,Process (engineering) ,Strategy and Management ,media_common.quotation_subject ,innovation cluster,innovation management,health care,project owner,conflict resolution,cluster development,value creation,industrial policy ,value creation ,Innovation management ,Business model ,Industrial policy ,0502 economics and business ,project owner ,conflict resolution ,media_common ,industrial policy ,cluster development ,innovation cluster ,business.industry ,05 social sciences ,General Engineering ,health care ,Computer Science Applications ,Cluster development ,Industrial relations ,[SHS.GESTION]Humanities and Social Sciences/Business administration ,050211 marketing ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Business ,Working group ,Law ,050203 business & management ,Autonomy ,Diversity (business) ,innovation management - Abstract
For more than ten years, the French State and administrative regions have pursued economic development policies that stimulate all forms of innovation and encourage strategic market alliances of the economic stakeholders of a region. These ‘cluster’ policies aim to create ecosystems that are conducive to innovation and promote the emergence of collaborative organisations. Among these innovation clusters, we are concerned with those in the healthcare field pertaining to ageing and autonomy. Business models and action plans for these collaborative organisations are neither easy to define nor easy to stabilise and reinforce, because of the diversity of stakeholders with multiple expectations involved. This paper presents an application of the FAcT-Mirror method in the Sol’iage (http://www.soliage.com/english-version/) innovation cluster during its development stage. We demonstrate that the FAcT-Mirror method is particularly efficient and effective during the process of transformation from the emerging stage (stage of intention) to the development stage (stage of action) for a healthcare cluster to collectively produce common tools (definitions, strategy, working groups, and action plans).
- Published
- 2014
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33. [Process and outcome of an internet-based preparation for inpatient psychosomatic psychotherapeutic treatment: an examination of website use]
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Benjamin, Zimmer
- Subjects
Adult ,Male ,Internet ,Motivation ,Text Messaging ,Feedback, Psychological ,Social Support ,Middle Aged ,Psychophysiologic Disorders ,Peer Group ,Psychotherapy ,Self-Help Groups ,Patient Admission ,Treatment Outcome ,Patient Education as Topic ,Patient Satisfaction ,Germany ,Surveys and Questionnaires ,Humans ,Female ,Software - Abstract
A main challenge for evaluating online intervention is to identify which elements are used and to identify participants who are more engaged.The study analyzes data on intervention use of an Internet-based preparation for inpatient psychosomatic psychotherapeutic treatment (VORSTAT).Data were available for 176 participants enrolled into VORSTAT from July 2009 to February 2011. The utilization of the program turned out to be very different across the users. Those who used all program features reported at registration more severe impairment, lived further away from the hospital, and had a longer waiting period. Regarding treatment outcome no differences between high and low utilizers were found.The exploration of process characteristics is critical in the evaluation of Internet-based applications and improved knowledge about individual's usage of online interventions enable us to better tailor therapy according to the individual patients' characteristics and hopefully enhance the efficacy.
- Published
- 2013
34. Building of usage scenarios space for investigating the fall situations of the elderly people
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Alborz Bekhradi, Bernard Yannou, Benjamin Zimmer, Romain Farel, Laboratoire Génie Industriel - EA 2606 (LGI), CentraleSupélec, and Yannou, Bernard
- Subjects
[INFO.INFO-AI] Computer Science [cs]/Artificial Intelligence [cs.AI] ,[SPI.OTHER]Engineering Sciences [physics]/Other ,Engineering ,Process (engineering) ,business.industry ,[SPI.OTHER] Engineering Sciences [physics]/Other ,Space (commercial competition) ,[INFO.INFO-IA]Computer Science [cs]/Computer Aided Engineering ,computer.software_genre ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,Oracle ,[INFO.INFO-IA] Computer Science [cs]/Computer Aided Engineering ,Task (project management) ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,Market segmentation ,Risk analysis (engineering) ,Data mining ,[INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation ,Situational ethics ,Set (psychology) ,business ,computer ,ComputingMilieux_MISCELLANEOUS ,Fall prevention - Abstract
Assessing the number of users defined by a set of specific usage attributes in a given usage contextual situation is not always an obvious task in a market segmentation process. Although new approaches in design and marketing seem to be more sensitive to the adequacy of a design concept with the usage scenarios, these methods do not systematically consider the various usage situations. The present article puts forward a methodology intending to build a usage scenarios space in which the input data is thoroughly collected and validated. This methodology is applied to the complex and multifactorial issue of falls among the elderly in the Metropolitan France. In this paper, numerous medical publications have been made to study influential factors of fall situations. However, even solution providers for fall prevention and teleassistance ignore the real situational coverage of their solutions. As a result, “usage scenarios space” is built using an appropriate segmentation of usage contexts (here, fall situations) and user characteristics. These data are used for a design oracle to predict (simulate) the various and multiple usage scenarios.Copyright © 2013 by ASME
- Published
- 2013
35. Three-dimensional-printed gas dynamic virtual nozzles for x-ray laser sample delivery
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Izumi Ishigami, Benjamin Zimmer, Henry N. Chapman, Masahide Hikita, John C. H. Spence, Tomáš Faragó, Fabian B.P. Niesler, Tilo Baumbach, Richard A. Kirian, Michael Heymann, Syun Ru Yeh, Uwe Weierstall, Fabian Wilde, Saša Bajt, Denis L. Rousseau, Nadia A. Zatsepin, and Garrett Nelson
- Subjects
0301 basic medicine ,Diffraction ,Rapid prototyping ,Fabrication ,Materials science ,business.industry ,Nozzle ,3D printing ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Laser ,Article ,Atomic and Molecular Physics, and Optics ,law.invention ,03 medical and health sciences ,030104 developmental biology ,Optics ,law ,Femtosecond ,ddc:530 ,0210 nano-technology ,business ,Biological imaging - Abstract
Reliable sample delivery is essential to biological imaging using X-ray Free Electron Lasers (XFELs). Continuous injection using the Gas Dynamic Virtual Nozzle (GDVN) has proven valuable, particularly for time-resolved studies. However, many important aspects of GDVN functionality have yet to be thoroughly understood and/or refined due to fabrication limitations. We report the application of 2-photon polymerization as a form of high-resolution 3D printing to fabricate high-fidelity GDVNs with submicron resolution. This technique allows rapid prototyping of a wide range of different types of nozzles from standard CAD drawings and optimization of crucial dimensions for optimal performance. Three nozzles were tested with pure water to determine general nozzle performance and reproducibility, with nearly reproducible off-axis jetting being the result. X-ray tomography and index matching were successfully used to evaluate the interior nozzle structures and identify the cause of off-axis jetting. Subsequent refinements to fabrication resulted in straight jetting. A performance test of printed nozzles at an XFEL provided high quality femtosecond diffraction patterns. (C) 2016 Optical Society of America
- Published
- 2016
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36. La grille de sélection dans la méthode SAPIGE®
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Benjamin Zimmer
- Abstract
Vous avez probablement ete amene a selectionner un projet d’innovation parmi d’autres dans un incubateur, un cluster d’innovation ou en entreprise. N’avez-vous pas deja eu le sentiment d’etre passe a cote d’une superbe opportunite sous pretexte que le dossier de candidature n’etait pas suffisamment robuste ? La selection d’un projet d’innovation, a partir d’une idee, est complexe, particulierement lorsque le marche vise est emergent. Cette fiche vous presente une grille de selection de projet d’innovation, partie integrante du systeme Sapige®, qui s’inspire de la methodologie Radical Innovation Design®. L’ensemble des vingt-trois criteres de selection (ou elements de preuve) de cette grille sont detailles. Quels sont les types de preuves a rassembler pour mesurer le potentiel d’une idee ? Comment utiliser une grille de selection ? Avec quels criteres ? Peut-on utiliser cet outil pour mesurer l’avancement de son propre projet d’innovation ?
- Published
- 2012
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37. Utiliser la méthode PAT Miroir® pour créer les bonnes pratiques de management
- Author
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Benjamin Zimmer
- Abstract
Il est unanimement reconnu que la reussite d’un projet collaboratif passe par la mise en place d’un climat de cooperation entre des acteurs regroupes dans une equipe collaborative interprofessionnelle. Souhaitez-vous ameliorer les conditions de collaboration (langage commun, comprehension des competences de chacun, repartition des valeurs et plan d’actions) ? Ces conditions semblent simples a mettre en œuvre, et pourtant leur mise en place est necessaire pour resoudre un probleme complexe lors de la conception d’un nouveau produit et/ou service. Les equipes collaboratives se penchent rarement sur cette question suffisamment en amont des problemes pour pouvoir les desamorcer rapidement. En effet, n’avez-vous pas deja abandonne un projet collaboratif car les interets des uns et des autres etaient mal compris ? Avez-vous deja tente de les resoudre en reunissant l’ensemble des acteurs mais, faute de consortium, le probleme n’a pas ete resolu ? Avez-vous deja ete confronte a un manque de valorisation dans la production d’un resultat issu d’un travail collaboratif ? Cette fiche presente la methode PAT Miroir®, une methode originale et adaptee a la construction d’une equipe collaborative interprofessionnelle. Elle permet de : resoudre un probleme complexe du a des representations differentes des objectifs, tâches et actions des acteurs d’une equipe collaborative ; dresser un diagnostic de la situation avant ou apres la creation d’une equipe collaborative interprofessionnelle ; construire collectivement un plan d’actions pour realiser un projet complexe (conception d’un nouveau produit et/ou service) ou resoudre un probleme complexe du a un probleme relationnel entre les parties prenantes (changement ou conception d’une nouvelle organisation collaborative) ; desactiver les peurs, augmenter les attraits et neutraliser les tentations entre les parties prenantes d’un projet complexe ; evaluer les interactions entre les acteurs qui posent ou qui pourraient venir rompre la dynamique de la cooperation ; faire prendre conscience a l’ensemble des acteurs que l’impact de leur action a une incidence sur la realisation des autres actions et l’engagement des autres acteurs ; evaluer les ressentis de chacun des acteurs avant, pendant ou apres la realisation d’un projet complexe.
- Published
- 2011
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38. Évaluer la faisabilité d’innovation d’un nouveau produit
- Author
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Benjamin Zimmer
- Abstract
La conception innovante pour les seniors est un defi de taille pour le XXI eme siecle. Concevoir pour les seniors porte en soi les plus grandes difficultes de l’innovation : le marche est complexe et en emergence, le nombre d’acteurs impliques pour aller d’une idee potentielle d’un nouveau produit et/ou service a un succes sur le marche est tres important, les obstacles et erreurs a eviter tres nombreux, chacun d’entre eux pouvant etre fatal et conditionner la prise d’une mauvaise decision. Une methodologie outillee est plus que jamais indispensable pour transformer une intuition en une opportunite commerciale creatrice de richesse. Que vous soyez directeur de l’innovation, porteur de projet ou entrepreneur, vous etes souvent amene a vous poser de nombreuses questions de differentes natures (financiere, manageriale, technique, medicale, commerciale, juridique, marketing). Ainsi, cette fiche vous presente une carte de navigation pour vous guider au travers d’une liste de bonnes pratiques que vous pourrez utiliser, particulierement en phase amont de conception d’un nouveau produit et/ou service destine aux seniors, et vous permettre de : preciser votre ambition et decrire votre idee ; assembler les elements de preuve de valeur (votre idee est utile et profitable), de concept (ca marche effectivement et c’est faisable industriellement) et d’innovation (c’est differenciant par rapport a des produits commercialises) ; evaluer les competences et connaissances que vous devrez acquerir pour concevoir votre equipe projet, votre plan d’actions et mieux mesurer les opportunites du marche ; evaluer et apprecier les risques d’un investissement (temporel et financier) personnel dans le developpement d’un nouveau produit et/ou service ; degager les strategies industrielles en termes de modele economique, de penetration du marche et de marketing.
- Published
- 2011
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39. A design and evaluation program for longer-life products
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L. Dechesne, Bernard Yannou, A. De Touchet, J. Stal-le Cardinal, François Piette, and Benjamin Zimmer
- Subjects
Engineering ,business.industry ,Biomedical Engineering ,Engineering ethics ,Geriatrics and Gerontology ,business ,Gerontology ,Management - Published
- 2009
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40. Chat-und E-Mail-Brücke: Nachsorge nach stationärer Psychotherapie
- Author
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Markus Wolf, Benjamin Zimmer, and Peter Dogs
- Abstract
In diesem Kapitel werden zwei internetbasierte Programme-Chat-und E-Mail-Brucke-zur Optimierung der integrierten psychosozialen Versorgung vorgestellt. Die Angebote wurden von der Forschungsstelle fur Psychotherapie in Zusammenarbeit mit der Panorama-Fachklinik fur Psychosomatik, Psychotherapeutische Medizin und Naturheilverfahren Scheidegg/Allgau konzipiert und entwickelt. Sie richten sich an Patienten, die nach ihrer Entlassung aus der stationaren Therapie eine Weiterbetreuung wahrend der kritischen Phase des Ubergangs von der Klinik in den Alltag (mit oder ohne ambulante Behandlung) wunschen.
- Published
- 2008
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41. Gruppenpsychotherapie im Internet-Chat
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Benjamin Zimmer, Hans Kordy, and Severin Haug
- Published
- 2008
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42. New Microscopes, New Telescopes: A Conversation with Mark Liberman About the Uncertain Future of Linguistics
- Author
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Benjamin Zimmer
- Subjects
Linguistics and Language ,Communication ,media_common.quotation_subject ,Philosophy ,Conversation ,Language and Linguistics ,Linguistics ,media_common - Published
- 2012
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43. Amifostine (WR-2721) Mitigates Cognitive Injury Induced by Heavy Ion Radiation in Male Mice and Alters Behavior and Brain Connectivity
- Author
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Sydney Weber Boutros, Benjamin Zimmerman, Sydney C. Nagy, Joanne S. Lee, Ruby Perez, and Jacob Raber
- Subjects
amifostine ,heavy ion radiation ,cognition ,cFos ,sex differences ,Physiology ,QP1-981 - Abstract
The deep space environment contains many risks to astronauts during space missions, such as galactic cosmic rays (GCRs) comprised of naturally occurring heavy ions. Heavy ion radiation is increasingly being used in cancer therapy, including novel regimens involving carbon therapy. Previous investigations involving simulated space radiation have indicated a host of detrimental cognitive and behavioral effects. Therefore, there is an increasing need to counteract these deleterious effects of heavy ion radiation. Here, we assessed the ability of amifostine to mitigate cognitive injury induced by simulated GCRs in C57Bl/6J male and female mice. Six-month-old mice received an intraperitoneal injection of saline, 107 mg/kg, or 214 mg/kg of amifostine 1 h prior to exposure to a simplified five-ion radiation (protons, 28Si, 4He, 16O, and 56Fe) at 500 mGy or sham radiation. Mice were behaviorally tested 2–3 months later. Male mice that received saline and radiation exposure failed to show novel object recognition, which was reversed by both doses of amifostine. Conversely, female mice that received saline and radiation exposure displayed intact object recognition, but those that received amifostine prior to radiation did not. Amifostine and radiation also had distinct effects on males and females in the open field, with amifostine affecting distance moved over time in both sexes, and radiation affecting time spent in the center in females only. Whole-brain analysis of cFos immunoreactivity in male mice indicated that amifostine and radiation altered regional connectivity in areas involved in novel object recognition. These data support that amifostine has potential as a countermeasure against cognitive injury following proton and heavy ion irradiation in males.
- Published
- 2021
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44. Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet
- Author
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Benjamin Zimmerman, Payel Kundu, Zheng Liu, Henryk F. Urbanski, Christopher D. Kroenke, Steven G. Kohama, Cynthia L. Bethea, and Jacob Raber
- Subjects
menopause ,hormone replacement therapy ,obesogenic diet ,neurodegeneration ,aging ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
The consumption of a diet high in fat and refined sugars has several health risks, including the development of cognitive decline and neurodegeneration. For women, menopause carries additional health risks that may interact with a high-fat diet in negative ways. Some symptoms of menopause, including cognitive impairments, can be modulated by hormone replacement therapy (HRT), but the hormonal formulation and the timing of the treatment relative to the onset of menopause are critical factors determining its efficacy. Little is known about how obesogenic, high-fat, high-sugar diets interact with HRT in menopause to affect cognition and neurodegeneration. Given the high prevalence of the consumption of an obesogenic Western-style diet, understanding how the effects of HRT are modulated by an obesogenic diet is critical for developing optimized therapeutic strategies for peri- and post-menopausal women. In this study, we investigated by magnetic resonance imaging (MRI) the effects of either immediate or delayed estradiol hormone therapy on cognition and neuroanatomy following ovo-hysterectomy (OvH) of aged, female rhesus macaques on an obesogenic diet. The macaques were followed for 2.5 years after ovo-hysterectomy, with four time points at which anatomical MRIs were acquired. Analysis of hippocampal volumes revealed an interaction between time point and treatment; hippocampal volumes in the delayed estrogen group, but not the immediate estrogen group, increased over time compared to those in untreated controls. Performance on a hippocampal-dependent spatial maze task showed improved performance in estrogen treated animals compared to OvH macaques given placebo. These results indicate that HRT may contribute to beneficial cognitive outcomes after menopause under an obesogenic diet.
- Published
- 2020
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45. Functional Brain Changes During Mindfulness-Based Cognitive Therapy Associated With Tinnitus Severity
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Benjamin Zimmerman, Megan Finnegan, Subhadeep Paul, Sara Schmidt, Yihsin Tai, Kelly Roth, Yuguo Chen, and Fatima T. Husain
- Subjects
tinnitus ,mindfulness-based cognitive therapy ,resting state MRI ,functional MRI ,graph connectivity analysis ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Mindfulness-based therapies have been introduced as a treatment option to reduce the psychological severity of tinnitus, a currently incurable chronic condition. This pilot study of twelve subjects with chronic tinnitus investigates the relationship between measures of both task-based and resting state functional magnetic resonance imaging (fMRI) and measures of tinnitus severity, assessed with the Tinnitus Functional Index (TFI). MRI was measured at three time points: before, after, and at follow-up of an 8-week long mindfulness-based cognitive therapy intervention. During the task-based fMRI with affective sounds, no significant changes were observed between sessions, nor was the activation to emotionally salient compared to neutral stimuli significantly predictive of TFI. Significant results were found using resting state fMRI. There were significant decreases in functional connectivity among the default mode network, cingulo-opercular network, and amygdala across the intervention, but no differences were seen in connectivity with seeds in the dorsal attention network (DAN) or fronto-parietal network and the rest of the brain. Further, only resting state connectivity between the brain and the amygdala, DAN, and fronto-parietal network significantly predicted TFI. These results point to a mostly differentiated landscape of functional brain measures related to tinnitus severity on one hand and mindfulness-based therapy on the other. However, overlapping results of decreased amygdala connectivity with parietal areas and the negative correlation between amygdala-parietal connectivity and TFI is suggestive of a brain imaging marker of successful treatment.
- Published
- 2019
- Full Text
- View/download PDF
46. The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
- Author
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Benjamin Zimmerman, Payel Kundu, William D. Rooney, and Jacob Raber
- Subjects
high-fat diet ,species differences ,cardiovascular health ,metabolism ,cerebrovasculature ,cognition ,Organic chemistry ,QD241-441 - Abstract
In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health.
- Published
- 2021
- Full Text
- View/download PDF
47. The Optical Effective Attenuation Coefficient as an Informative Measure of Brain Health in Aging
- Author
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Antonio M. Chiarelli, Kathy A. Low, Edward L. Maclin, Mark A. Fletcher, Tania S. Kong, Benjamin Zimmerman, Chin Hong Tan, Bradley P. Sutton, Monica Fabiani, and Gabriele Gratton
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diffuse optical imaging (DOI) ,effective attenuation coefficient (EAC) ,aging ,cortical thinning ,FreeSurfer ,Applied optics. Photonics ,TA1501-1820 - Abstract
Aging is accompanied by widespread changes in brain tissue. Here, we hypothesized that head tissue opacity to near-infrared light provides information about the health status of the brain’s cortical mantle. In diffusive media such as the head, opacity is quantified through the Effective Attenuation Coefficient (EAC), which is proportional to the geometric mean of the absorption and reduced scattering coefficients. EAC is estimated by the slope of the relationship between source−detector distance and the logarithm of the amount of light reaching the detector (optical density). We obtained EAC maps across the head in 47 adults (age range 18−75 years), using a high-density dual-wavelength optical system. We correlated regional and global EAC measures with demographic, neuropsychological, structural and functional brain data. Results indicated that EAC values averaged across wavelengths were strongly associated with age-related changes in cortical thickness, as well as functional and neuropsychological measures. This is likely because the EAC largely depends on the thickness of the sub-arachnoid cerebrospinal fluid layer, which increases with cortical atrophy. In addition, differences in EAC values between wavelengths were correlated with tissue oxygenation and cardiorespiratory fitness, indicating that information about cortical health can be derived non-invasively by quantifying the EAC.
- Published
- 2019
- Full Text
- View/download PDF
48. Mapping cerebral pulse pressure and arterial compliance over the adult lifespan with optical imaging.
- Author
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Chin Hong Tan, Kathy A Low, Tania Kong, Mark A Fletcher, Benjamin Zimmerman, Edward L Maclin, Antonio M Chiarelli, Gabriele Gratton, and Monica Fabiani
- Subjects
Medicine ,Science - Abstract
Cerebrovascular health is important for maintaining a high level of cognitive performance, not only in old age, but also throughout the lifespan. Recently, it was first demonstrated that diffuse optical imaging measures of pulse amplitude and arterial compliance can provide estimates of cerebral arterial health throughout the cortex, and were associated with age, estimated cardiorespiratory fitness (eCRF), neuroanatomy and cognitive function in older adults (aged 55-87). The current study replicates and extends the original findings using a broader age range (a new adult sample aged 18-75), longer recording periods (360 s), and a more extensive optical montage (1536 channels). These methodological improvements represent a 5-fold increase in recording time and a 4-fold increase in coverage compared to the initial study. Results show that reliability for both pulse amplitude and compliance measures across recording blocks was very high (r(45) = .99 and .75, respectively). Pulse amplitude and pulse pressure were shown to correlate with age across the broader age range. We also found correlations between arterial health and both cortical and subcortical gray matter volumes. Additionally, we replicated the correlations between arterial compliance and age, eCRF, global brain atrophy, and cognitive flexibility. New regional analyses revealed that higher performance on the operation span (OSPAN) working memory task was associated with greater localized arterial compliance in frontoparietal cortex, but not with global arterial compliance. Further, greater arterial compliance in frontoparietal regions was associated with younger age and higher eCRF. These associations were not present in the visual cortex. The current study not only replicates the initial one in a sample including a much wider age range, but also provides new evidence showing that frontoparietal regions may be especially vulnerable to vascular degeneration during brain aging, with potential functional consequences in cognition.
- Published
- 2017
- Full Text
- View/download PDF
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