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Volcanic eruptions impact climate, subtly and profoundly. The size of an eruption is only loosely correlated with the severity of its climate effects, which can include changes in surface temperature, ozone levels, stratospheric dynamics, precipitation, and ocean circulation. We review the processes—in magma chambers, eruption columns, and the oceans, biosphere, and atmosphere—that mediate the climate response to an eruption. A complex relationship between eruption size, style, duration, and the subsequent severity of the climate response emerges. We advocate for a new, consistent metric, the Volcano-Climate Index, to categorize climate response to eruptions independent of eruption properties and spanning the full range of volcanic activity, from brief explosive eruptions to long-lasting flood basalts. A consistent metric for categorizing the climate response to eruptions that differ in size, style, and duration is critical for establishing the relationshipbetween the severity and the frequency of such responses aiding hazard assessments, and furthering understanding of volcanic impacts on climate on timescales of years to millions of years. ▪ We review the processes driving the rocky relationship between eruption size and climate response and propose a Volcano-Climate Index. ▪ Volcanic eruptions perturb Earth's climate on a range of timescales, with key open questions regarding how processes in the magmatic system, eruption column, and atmosphere shape the climate response to volcanism. ▪ A Volcano-Climate Index will provide information on the volcano-climate severity-frequency distribution, analogous to earthquake hazards. ▪ Understanding of the frequency of specific levels of volcanic climate effects will aid hazard assessments, planning, and mitigation of societal impacts.

There is limited evidence to support pharmacogenetic (PGx) testing in children. We conducted a retrospective review of PGx testing among 452 patients at an academic children's hospital to determine the potential utility of PGx in diseases of childhood and to identify targets for future pediatric pharmacogenetic research. An actionable gene-drug pair associated with the 28 genes tested (Clinical Pharmacogenetics Implementation Consortium (CPIC) level A or B, Pharmacogenomics Knowledge Base (PharmGKB) level 1A or B, or US Food and Drug Administration (FDA) recommendation and a PharmGKB level) was present in 98.7% of patients. We identified 203 actionable gene-drug-diagnosis groups based on the indications for each actionable drug listed in Lexicomp. Among patients with an actionable gene-drug-diagnosis group, 49.3% had a diagnosis where the drug was a therapeutic option and PGx could be used to guide treatment selection. Among patients with an associated diagnosis, 30.9% had a prescription for the actionable drug allowing PGx guided dosing. Three genes (CYP2C19, CYP2D6, and CYP3A5) accounted for all the gene-drug-diagnosis groups with matching diagnoses and prescriptions. The most common gene-drug-diagnosis groups with matching diagnoses and prescriptions were CYP2C19-citalopram-escitalopram-depression 3.3% of patients tested; CYP2C19-dexlansoprazole-gastritis-esophagitis 3.1%; CYP2C19-omeprazole-gastritis-esophagitis 2.4%; CYP2D6-atomoxetine-attention deficit hyperactivity disorder 2.2%; and CYP2C19-citalopram-escitalopram-obsessive-compulsive disorder 1.5%. PGx could be used to guide selection of current treatment options or medication dosing in almost half (48.7%) of pediatric patients tested. Mood disorders and gastritis/esophagitis are promising targets for future study of PGx testing because of the high prevalence of these diagnoses and associated actionable gene-drug pairs in the pediatric population.

The Permian-Triassic extinction was the most severe in Earth history. The Siberian Traps eruptions are strongly implicated in the global atmospheric changes that likely drove the extinction. A sharp negative carbon isotope excursion coincides within geochronological uncertainty with the oldest dated rocks from the Norilsk section of the Siberian flood basalts. We focused on the voluminous volcaniclastic rocks of the Siberian Traps, relatively unstudied as potential carriers of carbon-bearing gases. Over six field seasons we collected rocks from across the Siberian platform, and we show here the first direct evidence that the earliest eruptions in the southern part of the province burned large volumes of a combination of vegetation and coal. We demonstrate that the volume and composition of organic matter interacting with magmas may explain the global carbon isotope signal and may have significantly driven the extinction.

Background/Purpose: Bullying is a destructive and pervasive phenomenon, having lasting physical and emotional consequences. It affects all ages, but is particularly poignant in middle and high school youths. Although the literature suggests that children with chronic health conditions are at higher risk of being bullied, there is minimal research regarding how children with visible orthopaedic conditions are affected. Our study aimed to assess the prevalence of bullying among patients seen in pediatric orthopaedic clinics, and to evaluate how orthopaedic conditions and use of orthopaedic assistive devices/equipment …

A 2 to 4 °C warming episode, known as the Latest Maastrichtian warming event (LMWE), preceded the Cretaceous–Paleogene boundary (KPB) mass extinction at 66.05 ± 0.08 Ma and has been linked with the onset of voluminous Deccan Traps volcanism. Here, we use direct measurements of melt-inclusion CO(2) concentrations and trace-element proxies for CO(2) to test the hypothesis that early Deccan magmatism triggered this warming interval. We report CO(2) concentrations from NanoSIMS and Raman spectroscopic analyses of melt-inclusion glass and vapor bubbles hosted in magnesian olivines from pre-KPB Deccan primitive basalts. Reconstructed melt-inclusion CO(2) concentrations range up to 0.23 to 1.2 wt% CO(2) for lavas from the Saurashtra Peninsula and the Thakurvadi Formation in the Western Ghats region. Trace-element proxies for CO(2) concentration (Ba and Nb) yield estimates of initial melt concentrations of 0.4 to 1.3 wt% CO(2) prior to degassing. Our data imply carbon saturation and degassing of Deccan magmas initiated at high pressures near the Moho or in the lower crust. Furthermore, we find that the earliest Deccan magmas were more CO(2) rich, which we hypothesize facilitated more efficient flushing and outgassing from intrusive magmas. Based on carbon cycle modeling and estimates of preserved lava volumes for pre-KPB lavas, we find that volcanic CO(2) outgassing alone remains insufficient to account for the magnitude of the observed latest Maastrichtian warming. However, accounting for intrusive outgassing can reconcile early carbon-rich Deccan Traps outgassing with observed changes in climate and atmospheric pCO(2).

A 2 to 4 °C warming episode, known as the Latest Maastrichtian warming event (LMWE), preceded the Cretaceous–Paleogene boundary (KPB) mass extinction at 66.05 ± 0.08 Ma and has been linked with the onset of voluminous Deccan Traps volcanism. Here, we use direct measurements of melt-inclusion CO2 concentrations and trace-element proxies for CO2 to test the hypothesis that early Deccan magmatism triggered this warming interval. We report CO2 concentrations from NanoSIMS and Raman spectroscopic analyses of melt-inclusion glass and vapor bubbles hosted in magnesian olivines from pre-KPB Deccan primitive basalts. Reconstructed melt-inclusion CO2 concentrations range up to 0.23 to 1.2 wt% CO2 for lavas from the Saurashtra Peninsula and the Thakurvadi Formation in the Western Ghats region. Trace-element proxies for CO2 concentration (Ba and Nb) yield estimates of initial melt concentrations of 0.4 to 1.3 wt% CO2 prior to degassing. Our data imply carbon saturation and degassing of Deccan magmas initiated at high pressures near the Moho or in the lower crust. Furthermore, we find that the earliest Deccan magmas were more CO2 rich, which we hypothesize facilitated more efficient flushing and outgassing from intrusive magmas. Based on carbon cycle modeling and estimates of preserved lava volumes for pre-KPB lavas, we find that volcanic CO2 outgassing alone remains insufficient to account for the magnitude of the observed latest Maastrichtian warming. However, accounting for intrusive outgassing can reconcile early carbon-rich Deccan Traps outgassing with observed changes in climate and atmospheric pCO2.

The Permo-Triassic Extinction was the most severe in Earth history. The Siberian Traps eruptions are strongly implicated in the global atmospheric changes that likely drove the extinction. A sharp negative carbon isotope excursion coincides within geochronological uncertainty with the oldest dated rocks from the Norilsk section of the Siberian flood basalts. The source of this light carbon has been debated for decades.We focused on the voluminous volcaniclastic rocks of the Siberian Traps, relatively unstudied as potential carriers of carbon-bearing gases. Over six field seasons we collected rocks from across the Siberian platform and show the first direct evidence that the earliest eruptions particularly in the southern part of the province burned large volumes of a combination of vegetation and coal. Samples from the Maymecha-Kotuy region, from the Nizhnyaya Tunguska, Podkamennaya Tunguska, and Angara Rivers all show evidence of high-temperature organic matter carbonization and combustion.Field evidence indicates a process in which ascending magmas entrain xenoliths of coal and carbonaceous sediments that are carbonized in the subsurface and also combusted either through reduction of magmas or when exposed to the atmosphere. We demonstrate that the volume and composition of organic matter interactions with magmas may explain the global carbon isotope signal, and have significantly driven the extinction.

OBJECTIVE To evaluate the associations of caregiver mobile phone problematic use and child problematic mealtime behaviors (PMBs) to improve understanding of the possible implications of caregiver mobile phone problematic use. METHODS Surveys were administered to caregivers of children aged 3 to 8 years. The survey included demographics, a validated measure for caregiver mobile phone problematic use (Mobile Phone Problematic Use Scale-10 [MPPUS-10]), and a validated measure for the perception of child PMB (Meals in our Household [MIOH]). The bivariate associations between child and caregiver characteristics, mobile phone problematic use, and PMBs of children were analyzed. Partial correlations examined these relations while controlling for significant (p ≤ 0.05) covariates. RESULTS Eighty-four caregivers (mean age 32.6 years, 63% white, 21% ≤ high school completion) participated. The correlation of MIOH problematic behavior total with MPPUS-10 was significant (r = 0.33, p ≤ 0.01). Significantly correlated caregiver variables with MPPUS-10 included age (r = -0.25, p = 0.02) and female sex (p = 0.01). No significant caregiver variables were noted for PMB. Child's age was significantly correlated with PMB (r = -0.27, p = 0.01). MPPUS-10 and PMB correlation remained significant when controlling for significant covariates. CONCLUSION A positive correlation existed between MPPUS-10 and PMB. Understanding the potential association between caregiver mobile phone problematic use and child PMB strengthens the pediatricians' ability to counsel about the implications of caregiver mobile phone problematic use when discussing child PMB.

Carbon is central to the formation and environmental impact of large igneous provinces (LIPs). These vast magmatic events occur over geologically short timescales and include voluminous flood basalts, along with silicic and low-volume alkaline magmas. Surface outgassing of CO2 from flood basalts may average up to 3,000 Mt per year during LIP emplacement and is subsidized by fractionating magmas deep in the crust. The large quantities of carbon mobilized in LIPs may be sourced from the convecting mantle, lithospheric mantle and crust. The relative significance of each potential carbon source is poorly known and probably varies between LIPs. Because LIPs draw on mantle reservoirs typically untapped during plate boundary magmatism, they are integral to Earth's long-term carbon cycle.

Siberian Traps flood basalt magmatism coincided with the end-Permian mass extinction approximately 252 million years ago. Proposed links between magmatism and ecological catastrophe include global warming, global cooling, ozone depletion and changes in ocean chemistry. However, the critical combinations of environmental changes responsible for global mass extinction are undetermined. In particular, the combined and competing climate effects of sulfur and carbon outgassing remain to be quantified. Here we present results from global climate model simulations of flood basalt outgassing that account for sulfur chemistry and aerosol microphysics with coupled atmosphere and ocean circulation. We consider the effects of sulfur and carbon in isolation and in tandem. We find that coupling with the ocean strongly influences the climate response to prolonged flood basalt-scale outgassing. We suggest that sulfur and carbon emissions from the Siberian Traps combined to generate systemic swings in temperature, ocean circulation and hydrology within a longer-term trend towards a greenhouse world in the early Triassic. Carbon and sulfur release from the Siberian Traps igneous province caused climate swings during the end-Permian mass extinction, according to coupled global climate simulations.

A simple device based on a tiny, coiled wire filament (CWF), similar in operation to solid phase microextraction (SPME), was reported almost a decade ago for sampling, concentrating, and minimizing contamination for Injection of liquid samples in gas chromatography (GC). However, the pliability of the platinum wire from which the CWF was fabricated was a hindrance when using this technique. In this work, we utilized a much stiffer stainless steel wire to form the CWF, and explored a number of ways to use it for sampling and sample introduction in GC and GC–MS. The coil radius and number of turns in the CWF (i.e., length of the coil) determined the sampling volume. The CWF was attached to a retractable plunger (part of a hand-held syringe-type holder) such that it could be retracted inside a 19 G needle for insertion into a standard GC injection port. Sampling was easily performed by either dipping the CWF in a liquid sample (i.e., sample dissolved in a solvent), which was drawn up into the wire coil by capillary action, or by applying a specific volume of liquid sample onto the CWF using a micro-syringe. Analytes trapped in/on the CWF could be introduced into the GC injection port before or after solvent evaporation. For semi-volatile compounds, the sample solvent was evaporated before injection, while for volatile compounds, some or all of the sample solvent was retained in the coil during injection. Repeatable volumes from 0.05 to 0.7 μL were sampled using CWFs with 5–70 turns, respectively, when sampling by dipping. Advantages of using a CWF compared to a conventional syringe include: (1) the chromatographic system is protected from contamination caused by accumulation of sample residues, (2) high quantitative repeatability is obtained for small volume injections (0.05–0.2 μL), (3) large sample injections can be performed for trace analysis by evaporating the solvent before injection, and (4) carryover and discrimination of semi-volatile compounds are minimized. These advantages enable easy and rapid (10 min total analysis time) trace (0.1–5 ppb) detection of a variety of different types of compounds, including polycyclic aromatic hydrocarbons, biphenyl congeners, organochlorine pesticides, pyrethroid pesticides, phthalate esters, and n -alkanes from C10 to C40 in water and waste water.

River systems reveal planetary tectonics Earth, Mars, and Titan have all hosted rivers at some point in their histories. Rivers erode the landscape, leaving behind signatures that depend on whether the surface topography was in place before, during, or after the period of liquid flow. Black et al. developed two metrics to measure how well river channels align with the surrounding large-scale topography (see the Perspective by Burr). Earth's plate tectonics introduce features such as mountain ranges that cause rivers to divert, processes that clearly differ from those found on Mars and Titan. Science , this issue p. 727 ; see also p. 708

Individual flood basalt lavas often exceed 10 3 km 3 in volume, and many such lavas erupt during emplacement of flood basalt provinces. The large volume of individual flood basalt lavas implies correspondingly large magma reservoirs within or at the base of the crust. To erupt, some fraction of this magma must become buoyant and overpressure must be sufficient to encourage failure and dike propagation. The overpressure associated with a new injection of magma is inversely proportional to the total reservoir volume, and as a large magma body heats the surrounding rocks thermally activated creep will relax isotropic overpressure more rapidly. Here, we examine the viability of buoyancy overpressure as a trigger for continental flood basalt eruptions. We employ a new one-dimensional model that combines volatile exsolution, bubble growth and rise, assimilation, and permeable fluid escape from Moho-depth and crustal chambers. We investigate the temporal evolution of degassing and the eruptibility of magmas using the Siberian Traps flood basalts as a test case. We suggest that the volatile inventory set during mantle melting and redistributed via bubble motion controls ascent of magma into and through the crust, thereby regulating the tempo of flood basalt magmatism. Volatile-rich melts from low degrees of partial melting of the mantle are buoyant and erupt to the surface with little staging or crustal interaction. Melts with moderate volatile budgets accumulate in large, mostly molten magma chambers at the Moho or in the lower crust. These large magma bodies may remain buoyant and poised to erupt—triggered by volatile-rich recharge or external stresses—for ∼ 10 6 yr . If and when such chambers fail, enormous volumes of magma can ascend into the upper crust, staging at shallow levels and initiating substantial assimilation that contributes to pulses of large-volume flood basalt eruption. Our model further predicts that the Siberian Traps may have released 10 19 – 10 20 g of CO2 during a number of brief ( ∼ 10 4 yr ) pulses, providing a plausible trigger for warming and ocean acidification during the end-Permian mass extinction. The assimilation of carbon-rich crustal rocks strongly enhances both flood basalt eruptibility and CO2 release, and the tempo of eruptions influences the environmental effects of CO2, SO2, and halogen degassing. The eruptive dynamics of flood basalts are thus inextricably linked with their environmental consequences.

This chapter provides the fundamental principles of care in obstetrics, taking into account important cultural considerations in humanitarian settings. The chapter lays out the general strategies to reduce maternal mortality and morbidity, and provides specific guidance for antenatal care, the medical management of the stages of labour, and postnatal care.

Recent revisions to our understanding of the collisional history of the Hadean and early-Archean Earth indicate that large collisions may have been an important geophysical process. In this work we show that the early bombardment flux of large impactors (>100 km) facilitated the atmospheric release of greenhouse gases (particularly CO2) from Earth's mantle. Depending on the timescale for the drawdown of atmospheric CO2, the Earth's surface could have been subject to prolonged clement surface conditions or multiple freeze-thaw cycles. The bombardment also delivered and redistributed to the surface large quantities of sulfur, one of the most important elements for life. The stochastic occurrence of large collisions could provide insights on why the Earth and Venus, considered Earth's twin planet, exhibit radically different atmospheres.

M06 density functional theory calculations reveal that arene C–H functionalization by the p-block main-group-metal complex TlIII(TFA)3 (TFA = trifluoroacetate) occurs by a C–H activation mechanism akin to transition-metal-mediated C–H activation. For benzene, toluene, and xylenes a one-step C–H activation is preferred over electron transfer or proton-coupled electron transfer. The proposed C–H activation mechanism is consistent with calculation and comparison to experiment, of arene thallation rates, regioselectivity, and H/D kinetic isotope effects. For tetramethyl- and pentamethyl-substituted arenes, electron transfer becomes a competitive pathway and thermodynamic and kinetic calculations correctly predict the experimentally reported electron transfer crossover region. These calculations show that p-block metals activate strong hydrocarbon C–H bonds through organometallic intermediates and changes in arene functional groups can result in a shift from C–H activation to electron transfer.

Author(s): Li, M; Black, B; Zhong, S; Manga, M; Rudolph, ML; Olson, P | Abstract: The Earth's surface volcanism exerts first-order controls on the composition of the atmosphere and the climate. On Earth, the majority of surface volcanism occurs at mid-ocean ridges. In this study, based on the dependence of melt fraction on temperature, pressure, and composition, we compute melt production and degassing rate at mid-ocean ridges from three-dimensional global mantle convection models with plate motion history as the surface velocity boundary condition. By incorporating melting in global mantle convection models, we connect deep mantle convection to surface volcanism, with deep and shallow mantle processes internally consistent. We compare two methods to compute melt production: a tracer method and an Eulerian method. Our results show that melt production at mid-ocean ridges is mainly controlled by surface plate motion history, and that changes in plate tectonic motion, including plate reorganizations, may lead to significant deviation of melt production from the expected scaling with seafloor production rate. We also find a good correlation between melt production and degassing rate beneath mid-ocean ridges. The calculated global melt production and CO2 degassing rate at mid-ocean ridges varies by as much as a factor of 3 over the past 200 Myr. We show that mid-ocean ridge melt production and degassing rate would be much larger in the Cretaceous, and reached maximum values at ∼150–120 Ma. Our results raise the possibility that warmer climate in the Cretaceous could be due in part to high magmatic productivity and correspondingly high outgassing rates at mid-ocean ridges during that time.

Author(s): Black, BA; Manga, M | Abstract: Magnetic and geologic data indicate that the ratio of intrusive to extrusive magmatism (the I/E ratio) is higher in the Tharsis and Syrtis Major volcanic provinces on Mars relative to most volcanic centers on Earth. The fraction of magmas that erupt helps to determine the effects of magmatism on crustal structure and the flux of magmatic gases to the atmosphere and also influences estimates of melt production inferred from the history of surface volcanism. We consider several possible controls on the prevalence of intrusive magmatism at Tharsis and Syrtis Major, including melt production rates, lithospheric properties, regional stresses and strain rates, and magmatic volatile budgets. The Curie temperature is the minimum crustal temperature required for thermal demagnetization, implying that if the primary magnetic mineral is magnetite or hematite, the crust was warm during the intrusive magmatism reflected in Tharsis and Syrtis Major I/E ratios. When wall rocks are warm, thermally activated creep relaxes stresses from magma replenishment and regional tectonics, and eruptibility depends on buoyancy overpressure. We develop a new one-dimensional model for the development of buoyancy in a viscous regime that accounts for cooling, crystallization, volatile exsolution, bubble coalescence and rise, fluid egress, and compaction of country rock. Under these conditions, we find that initial water and CO2 contents typically l1.5 wt % can explain the observed range of intrusive/extrusive ratios. Our results support the hypothesis that warm crust and a relatively sparse volatile budget encouraged the development of large intrusive complexes beneath Tharsis and Syrtis Major.

Caldera footprints and erupted magma volumes provide a unique constraint on vertical dimensions of upper crustal magma reservoirs that feed explosive silicic eruptions. Here we define a Vertical Separation (VS) ratio in which we compare the geometric vertical extent with the range of depths indicated petrologically by melt inclusion water and CO2 saturation pressures for fifteen caldera-forming eruptions spanning ∼100 km3 to ∼103 km3 in volume. We supplement melt inclusion saturation pressures with rhyolite-MELTS barometry and plagioclase-melt hygrometry to generate a petrologic image of magma reservoir architecture. We find that pre-eruptive upper crustal magma reservoirs range from contiguous bodies (where petrologic and geometric estimates match closely) to vertically dispersed structures. Vertically dispersed pre-eruptive reservoirs are more common among intermediate-volume eruptions than among the smallest and largest caldera-forming eruptions. We infer that the architecture of magma reservoirs tracks the thermomechanical evolution of large volcanic systems.

Large igneous province (LIP) eruptions have been linked in some cases to major perturbations of Earth's carbon cycle. However, few observations directly constrain the isotopic composition of carbon released by LIP magmas because carbon isotopes fractionate during degassing, which hampers understanding of the relative roles of mantle versus crustal carbon reservoirs. Carbonatite magmatism associated with LIPs provides a unique window into the isotopic systematics of LIP carbon because the majority of carbon in carbonatites crystalizes rather than degassing. Although the volume of such carbonatites is small, they offer one of the few available constraints on the mantle carbon originally hosted in other more voluminous magma types. Here, we present new δ 13 C data for the Guli carbonatites in the Siberian Traps. In addition, we compile ∼260 published measurements of δ 13 C from carbonatites related to the Deccan Traps and the Parana-Etendeka. We find no evidence for magmas with carbon isotope ratios lighter than depleted mantle values of δ 13 C = − 6 ± 2 ‰ from any of these LIPs, though some carbonatites range to heavier δ 13 C . We attribute relatively heavy δ 13 C in some carbonatites to either slightly 13C-enriched domains in the mantle lithosphere or carbon isotope fractionation in deep, carbon-saturated LIP magma reservoirs. The absence of a light δ 13 C component in LIP magmas supports the view that lithospheric carbon reservoirs must be tapped during cases of LIP magmatism linked with sharp negative carbon isotope excursions and mass extinctions.

Asteroid bombardment contributed to extensive melting and resurfacing of ancient (>3.5 Ga) Mars. Evidence from the largest impact structures on Earth and the Moon suggests that vertically thick impact melt sheets experience chemical differentiation. Recently observed materials in Gale crater are enriched in alkalis (up to 14 wt% Na2O + K2O) and silica (up to 67 wt% SiO2) with low MgO (

The moon Phobos will eventually either disintegrate to form a ring or crash into Mars. Observational constraints and geotechnical considerations suggest that Phobos will partially break apart into a ring, with stronger fragments impacting Mars.

The eruption of the Campanian Ignimbrite at ca. 40 ka coincided with the final decline of Neanderthals in Europe. Environmental stress associated with the eruption of the Campanian Ignimbrite has been invoked as a potential driver for this extinction as well as broader upheaval in Paleolithic societies. To test the climatic importance of the Campanian eruption, we used a three-dimensional sectional aerosol model to simulate the global aerosol cloud after release of 50 Tg and 200 Tg SO2. We coupled aerosol properties to a comprehensive earth system model under last glacial conditions. We find that peak cooling and acid deposition lasted one to two years and that the most intense cooling sidestepped hominin population centers in Western Europe. We conclude that the environmental effects of the Campanian Ignimbrite eruption alone were insufficient to explain the ultimate demise of Neanderthals in Europe. Nonetheless, significant volcanic cooling during the years immediately following the eruption could have impacted the viability of already precarious populations and influenced many aspects of daily life for Neanderthals and anatomically modern humans.

The Siberian Traps are one of the largest known continental flood basalt provinces and may be causally related to the end-Permian mass extinction. In some areas, a large fraction of the Siberian Traps volcanic sequence consists of mafic volcaniclastic rocks. Here, we synthesize paleomagnetic, petrographic, and field data to assess the likely origins of these volcaniclastic rocks and their significance for the overall environmental impact of the eruptions. We argue that magma-water interactions, including both lava-water interactions and phreatomagmatic explosions in vents, were important components of Siberian Traps magmatism. Phreatomagmatic episodes may have generated tall water-rich eruption columns, simultaneously promoting removal of highly soluble volcanic gases such as HCl and potentially delivering additional sulfur to the upper atmosphere.

The Siberian Traps flood basalts transferred a large mass of volatiles from the Earth's mantle and crust to the atmosphere. The eruption of the large igneous province temporally overlapped with the end-Permian mass extinction. Constraints on the sources of Siberian Traps volatiles are critical for determining the overall volatile budget, the role of crustal assimilation, the genesis of Noril'sk ore deposits, and the environmental effects of magmatism. We measure sulfur isotopic ratios ranging from − 10.8 ‰ to + 25.3 ‰ Vienna Canon Diablo Troilite (V-CDT) in melt inclusions from Siberian Traps basaltic rocks. Our measurements, which offer a snapshot of sulfur cycling far from mid-ocean ridge and arc settings, suggest the δ34S of the Siberian Traps mantle melt source was close to that of mid-ocean ridge basalts. In conjunction with previously published whole rock measurements from Noril'sk, our sulfur isotopic data indicate that crustal contamination was widespread and heterogeneous—though not universal—during the emplacement of the Siberian Traps. Incorporation of crustal materials likely increased the total volatile budget of the large igneous province, thereby contributing to Permian–Triassic environmental deterioration.

The Siberian Traps flood basalts have been invoked as a trigger for the catastrophic end-Permian mass extinction. Widespread aberrant plant remains across the Permian-Triassic boundary provide evidence that atmospheric stress contributed to the collapse in terrestrial diversity. We used detailed estimates of magmatic degassing from the Siberian Traps to complete the first three-dimensional global climate modeling of atmospheric chemistry during eruption of a large igneous province. Our results show that both strongly acidic rain and global ozone collapse are possible transient consequences of episodic pyroclastic volcanism and heating of volatile-rich Siberian country rocks. We suggest that in conjunction with abrupt warming from greenhouse gas emissions, these repeated, rapidly applied atmospheric stresses directly linked Siberian magmatism to end-Permian ecological failure on land. Our comprehensive modeling supplies the first picture of the global distribution and severity of acid rain and ozone depletion, providing testable predictions for the geography of end-Permian environmental proxies.

Yellowfin bream ( Acanthopagrus australis ) are considered a prime candidate for aquaculture and for release into estuaries to enhance wild stocks and recreational fishing along much of the east coast of Australia. The acclimation of wild yellowfin bream to captivity and the development of reliable protocols for inducing consistent multiple spawns for the mass production of larvae have not previously been reported. Four replicate trials were conducted to assess the efficacy of gonadotropin releasing hormone analogue (GnRHa) and human chorionic gonadotropin (hCG), to induce spontaneous spawning. In each trial, females were injected with a single dose of either saline (control), GnRHa (25, 50, 75, 100 μg kg − 1 ) or hCG (250, 500, 750, 1000 IU μg kg − 1 ). Control fish did not spawn, whereas treatment with either GnRHa or hCG induced spawning. However, the number of spawns and eggs produced from hCG treated females was not statistically significant from controls. Treatment with GnRHa at a dose of 75 μg kg − 1 resulted in the most consistent spawning response with both the mean number of spawns (3.0 ± 0.0 SD) and eggs produced (755,000 ± 152,000 SE) significant elevated from controls. However, the quality of eggs from GnRHa treated fish was variable. Egg fertilization rates of the first spawns from GnRHa and hCG treated females were inversely related to latency period, indicating that delayed spawning resulted in poor quality eggs. A second experiment was performed to examine if improvements in the quality of eggs from females (injected with GnRHa at a dose of 75 μg kg − 1 ) could be achieved by increasing the number of males placed with a single female. When a 3:1 male to female spawning ratio was used, the proportion of fertilized egg spawned improved over females spawned with a single male.

[1] Titan has few impact craters, suggesting that its surface is geologically young. Titan's surface also has abundant landforms interpreted to be fluvial networks. Here we evaluate whether fluvial erosion has caused significant resurfacing by estimating the cumulative erosion around the margins of polar lakes. A scarcity of detailed topographic data makes it difficult to measure fluvial incision on Titan, but images of drowned fluvial features around the lake margins, where elevated levels of hydrocarbon liquids appear to have partly flooded fluvial valleys, offer a constraint on the topography. We mapped the shorelines of several lakes to obtain topographic contours that trace the fluvially dissected topography. We then used a numerical landscape evolution model to calibrate a relationship between contour sinuosity, which reflects the extent of fluvial valley incision, and cumulative erosion. We confirmed this relationship by analyzing a partially dissected surface adjacent to the Minnesota River, USA. Comparison of the mapped Titan contours with the sinuosity-erosion relationship suggests that cumulative fluvial erosion around the margins of Titan's polar lakes, including Ligeia Mare, Kraken Mare, and Punga Mare in the north and Ontario Lacus in the south, ranges from 4% to 31% of the initial relief. Additional model simulations show that this amount of fluvial erosion does not render craters invisible at the resolution of currently available imagery, suggesting that fluvial erosion is not the only major resurfacing mechanism operating in Titan's polar regions.

Although Titan’s surface shows clear evidence of erosional modification, such as fluvial incision, evidence for tectonism has been less apparent. On Earth, fluvial networks with strongly preferred orientations are often associated with structural features, such as faults or joints, that influence flow or erodibility. We delineated and classified the morphologies of fluvial drainages on Titan and discovered evidence of structural control. Fluvial networks were delineated both on synthetic aperture radar (SAR) images covering ∼40% of Titan from the Cassini Titan Radar Mapper up through T71 and on visible light images of the Huygens landing site collected by the Descent Imager/Spectral Radiometer (DISR). The delineated networks were assigned to one of three morphologic classes—dendritic, parallel or rectangular—using a quantitative terrestrial drainage pattern classification algorithm modified for use with Titan data. We validated our modified algorithm by applying it to synthetic fluvial networks produced by a landscape evolution model with no structural control of drainage orientations, and confirmed that only a small fraction of the networks are falsely identified as structurally controlled. As a second validation, we confirmed that our modified algorithm correctly classifies terrestrial networks that are classified in multiple previous works as rectangular. Application of this modified algorithm to our Titan networks results in a classification of rectangular for one-half of the SAR and DISR networks. A review of the geological context of the four terrestrial rectangular networks indicates that tensional stresses formed the structures controlling those terrestrial drainages. Based on the similar brittle response of rock and cryogenic ice to stress, we infer that structures formed under tension are the most likely cause of the rectangular Titan networks delineated here. The distribution of these rectangular networks suggests that tensional stresses on Titan may have been widespread., United States. National Aeronautics and Space Administration (NASA Cassini Data Analysis Program Grant NNX08BA81G)

Recent rhyolitic volcanism has demonstrated that prolonged low-intensity ash venting may accompany effusive dome formation. We examine the possibility and some consequences of episodes of extended, weak ash venting at the rhyolitic Mono-Inyo chain in Eastern California. We describe ash-filled cracks within one of the youngest domes, Panum Crater, which provide a textural record of ash venting during dome effusion. We use synchrotron-based X-ray computed tomography to characterize the particles in these tuffisites. Particle sizes in well-sorted tuffisite layers agree well with grain size distributions observed during weak ash venting at Soufriere Hills Volcano, Montserrat, and yield approximate upper and lower bounds on gas velocity and mass flux during the formation of those layers. We simulate ash dispersal with Ash3d to assess the consequences of long-lived Mono-Inyo ash venting for ash deposition and the accompanying volcanic hazards. Our results highlight the sensitivity of large-scale outcomes of volcanic eruptions to small-scale processes.

Guanfacine, in the immediate release form, remains a commonly used medication for the treatment of clinically significant hyperactivity, impulsivity, or disruptive behaviors. This article reviews the available literature regarding guanfacine use in very young children (6 years of age), and explores some of the factors that may uniquely impact the clinical pharmacology of guanfacine in very young children and that deserve consideration when it is used in this patient population.The authors performed electronic literature searches in PubMed through October 2015 using the terms attention-deficit/hyperactivity disorder, guanfacine, and alpha agonists. We also performed an informal review of the literature and used selected articles from relevant reference lists. The result was a broad, qualitative review of the literature, with a focus on specific factors regarding guanfacine use in very young children.Despite the fact that guanfacine is commonly used in very young children, there is a paucity of published studies that looked specifically at its use in this population. In reviewing the pharmacology of guanfacine, there are specific factors that may play a unique role in its disposition in very young children.Guanfacine is an important medication option in very young children; however, there is a significant pharmacologic "information gap," and further research is needed to help establish appropriate, safe, and effective dosing of guanfacine in this population.

Fluvial features on Titan have been identified in synthetic aperture radar (SAR) data taken during spacecraft flybys by the Cassini Titan Radar Mapper (RADAR) and in Descent Imager/Spectral Radiometer (DISR) images taken during descent of the Huygens probe to the surface. Interpretations using terrestrial analogs and process mechanics extend our perspective on fluvial geomorphology to another world and offer insight into their formative processes. At the landscape scale, the varied morphologies of Titan’s fluvial networks imply a variety of mechanical controls, including structural influence, on channelized flows. At the reach scale, the various morphologies of individual fluvial features, implying a broad range of fluvial processes, suggest that (paleo-)flows did not occupy the entire observed width of the features. DISR images provide a spatially limited view of uplands dissected by valley networks, also likely formed by overland flows, which are not visible in lower-resolution SAR data. This high-resolution snapshot suggests that some fluvial features observed in SAR data may be river valleys rather than channels, and that uplands elsewhere on Titan may also have fine-scale fluvial dissection that is not resolved in SAR data. Radar-bright terrain with crenulated bright and dark bands is hypothesized here to be a signature of fine-scale fluvial dissection. Fluvial deposition is inferred to occur in braided channels, in (paleo)lake basins, and on SAR-dark plains, and DISR images at the surface indicate the presence of fluvial sediment. Flow sufficient to move sediment is inferred from observations and modeling of atmospheric processes, which support the inference from surface morphology of precipitation-fed fluvial processes. With material properties appropriate for Titan, terrestrial hydraulic equations are applicable to flow on Titan for fully turbulent flow and rough boundaries. For low-Reynolds-number flow over smooth boundaries, however, knowledge of fluid kinematic viscosity is necessary. Sediment movement and bed form development should occur at lower bed shear stress on Titan than on Earth. Scaling bedrock erosion, however, is hampered by uncertainties regarding Titan material properties. Overall, observations of Titan point to a world pervasively influenced by fluvial processes, for which appropriate terrestrial analogs and formulations may provide insight.

article i nfo The eruption of the Siberian Traps flood basalts has been invoked as a trigger for the catastrophic end- Permian mass extinction. Quantitative constraints on volatile degassing are critical to understanding the en- vironmental consequences of volcanism. We measured sulfur, chlorine, and fluorine in melt inclusions from the Siberian Traps and found that concentrations of these volatiles in some magmas were anomalously high compared to other continental flood basalts. For the ten samples for which we present data, volatile concen- trations in individual melt inclusions range from less than the detection limit to 0.51 wt.% S, 0.94 wt.% Cl, and 1.95 wt.% F. Degassing from the Siberian Traps released approximately ~6300-7800 Gt S, ~3400-8700 Gt Cl, and ~7100-13,600 Gt F. These large volatile loads, if injected into the stratosphere, may have contributed to a drastic deterioration in global environmental conditions during the end-Permian.

Adult yellowfin bream (Acanthopagrus australis) were captured from the wild and maintained in outdoor tanks until the onset of the natural spawning season (May ‐ June). Three replicate trials were conducted to examine the effects of gonadotropin releasing‐hormone analogue (GnRHa) and human chorionic gonadotropin (hCG) on milt characteristics and gonadal steroid levels. Spermiating males were injected intraperitoneally with either saline solution (control) or a single dose of GnRHa (25, 50, 75, 100 μg kg−1) or hCG (250, 500, 750, 1000 IU kg−1). Milt and blood samples were collected before hormone administration (0 h) to examine initial reproductive status, and at 6, 24, and 48 h post injection (p.i.) to assess the effects of hormone treatment. There was a progressive increase in the reproductive condition of fish held throughout the experimental period, with increases in milt volume and sperm concentration over time, and a corresponding fall in the duration of sperm activity. Treatment with saline...

Variants in the X-linked gene PCDH19 are associated with early infantile epileptic encephalopathy-9. This unusual condition spares hemizygous males except for psychiatric and behavioral abnormalities, and for this reason is also known as female limited epilepsy. Some cases are due to de novo PCDH19 variants, but may also be paternally inherited. Our patient is a 6-year-old male with epileptic encephalopathy. Exome sequencing revealed apparent heterozygosity in PCDH19 for a novel nonsense variant, c.605C>A (p.Ser202*), inconsistent with expectations for a male. Testing of other tissues revealed a mixture of mutant and normal alleles. These results are consistent with somatic mosaicism for p.Ser202*. This is the second male with somatic mosaicism for PCDH19 deficiency, providing further support for cellular interference as the pathogenic mechanism for this condition, which leads to this unusual mode of inheritance in which females are more severely affected than males. © 2016 Wiley Periodicals, Inc.