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Madelung's disease generally refers to a benign symmetrical lipomatosis of the neck, but its presentation can vary. It is treated surgically and different approaches can be implemented. In cases of a threatened airway, a tracheostomy can be performed., Madelung's disease generally refers to a benign symmetrical lipomatosis of the neck, but its presentation can vary. It is treated surgically and different approaches can be implemented. In cases of a threatened airway, a tracheostomy can be performed. ​

Benign symmetrical lipomatosis (BSL) is a rare pathological finding with an alcohol connection. It predominantly affects males in the age between 30 and 60-year-old. Once developed, the disease does not undergo regression. The fatty accumulations have constant and progressive overgrowth that may significantly affect breathing, eating and speech. The most effective method for treatment is the surgical removal of the tumor masses. In the following we present a clinical case report of a 44-year-old male with BSL.

This is a man in his 60s with benign symmetrical lipomatosis (fig 1). This rare (one in 25 0001) lipid metabolic disorder is characterised by symmetrical, diffuse proliferation of non-encapsulated adipose tissue in …

Benign symmetrical lipomatosis (Madelung's disease) is a rare condition of unclear aetiology characterized by numerous, unencapsulated lipomatous deposits. The only effective treatment is by surgical intervention; however, there is no consensus in the optimal approach. We present the case of a patient who required staged, multi-modality treatment to achieve disease quiescence. The case highlights the usefulness of magnetic resonance imaging as a tool for assessment as well as preoperative planning.

Paciente masculino, 42 anos, etilista crônico, apresentando quadro de tumorações em região cervical e ao redor dos ombros, lesões eritemato-violáceas, descamativas e algumas lesões bolhosas, nas áreas fotoexpostas dos membros superiores e inferiores. Baseado no quadro clínico e nos exames complementares, foi estabelecido o diagnóstico de pelagra associada à lipomatose simétrica benigna, sendo ambos os quadros justificados pelo etilismo crônico. Tratado com reposição de complexo B intravenoso e orientado quanto à importância da abstinência alcoólica, apresentou remissão completa do quadro cutâneo, porém sem alteração da lipomatose.

Madelung's disease, also known as benign symmetrical lipomatosis, is a rare proliferative disorder of unknown etiology that was first mentioned by Brodie in 1846. Characterized by multiple symmetrical deposits of unencapsulated fat in the head and neck region, the disease is most common in middle-aged men with a history of alcohol abuse. The only effective therapy in cases of dyspnea and dysphagia, indicating the necessity of treatment, is the surgical resection of the adipose tissue. The authors report on the evaluation and therapy in a case of giant Madelung's disease.

Malgré 150 ans d'histoire, la pathogenèse de la lipomatose bénigne symétrique (syndrome de Launois-Bensaude), maladie fréquemment associée à un abus chronique d'alcool, demeure énigmatique. Après description d'un cas souffrant de ce rare syndrome, une revue de la littérature est proposée, avec un accent particulier sur les hypothèses physiopathologiques, le diagnostic différentiel et le traitement chirurgical de cette lipomatose.

Benign symmetrical lipomatosis (BSL, Madelung's disease) is a rare disease characterized by a symmetrical accumulation of excessive amounts of adipocytes, predominantly in the neck, upper arms and upper trunk [1]. Although the etiology of BSL is unknown, the disease is associated with alcoholism in 60% to 90% of patients [2]. There is a predominance for males, with a reported male:female ratio ranging from 15:1 to 30:1 [2]. We report a rare female case of benign symmetric lipomatosis.A 46-year-old [...]

65歳の男性。初診の10年前に下顎部, 前胸部に自覚症状のない軟らかい腫瘤の出現に気づいていたが, その後, 上腕, 後頚部にも同様の腫瘤を認め徐々に増大してきた。病理組織像では被膜を有さない成熟した脂肪細胞の増殖がみられた。内分泌学的異常を認めず, その特異な臨床像よりbenign symmetrical lipomatosisと診断した。脂肪細胞培養の結果, 患者の病変部脂肪細胞は高い増殖能を示した。

A case of benign symmetrical lipomatosis of neck in a 10 year, thinly built child is presented with outline of possible etiology and treatment. Since this disease barely finds mention in otolaryngotogy textbooks, although these patients usually first present to olotaryngologists, this case is reported to make aware the young fraternity with the disease entity.

A patient with benign symmetrical lipomatosis of the neck (Madelung's disease) was successfully treated with liposuction rather than classic surgical lipectomy. To our knowledge this is only the second such patient treated in this way.

La aparición de un cáncer de esófago en mujeres que previamente han recibido radioterapia como tratamiento de un cáncer de mama es un hecho conocido aunque poco frecuente. El riesgo de aparición de la segunda neoplasia es mayor cuando han transcurrido diez o más años desde la exposición a la radiación. La estirpe histológica de la neoplasia de esófago más frecuente es la de carcinoma de células escamosas. Se presenta un caso de adenocarcinoma de esófago en un varón, diagnosticado de lipomatosis bilateral simétrica o enfermedad de Madelung, que recibió radioterapia tres años antes por presentar un cáncer de mama.

Benign symmetrical lipomatosis (BSL) is a rare disorder characterized by the presence of multiple, symmetric, nonencapsulated fat masses in the face, neck, and other areas. Typically, this entity has been related to the presence of three anterior bulges in the neck. The disorder was first described by Brodie in 1846. After that, Madelung in 1888 and Launois and Bensaude in 1898 characterized the disease. There are multiple synonyms for this disorder, such as Madelung’s disease, Launois–Bensaude syndrome, and multiple symmetrical lipomatosis. Benign symmetric lipomatosis is usually described in adults from 30 to 60 years old, with an incidence of about 1 in 25,000 and a male-to-female ratio of 15:1 to 30:1. Most cases have no hereditary pattern. More than 90% of the patients have associated alcoholism. The ethiology of benign symmetric lipomatosis remains unknown, but an abnormal lipogenesis induced by catecholamines has been observed. The transformation of BSL to a malignant tumor is extremely rare. In the current report, the authors describe two cases of benign symmetric lipomatosis treated in their department and a review of the literature.

Benign symmetrical lipomatosis (Madelung syndrome) is a rare disease of unknown aetiology, which is characterised by diffuse growth of non-encapsulated lipomas. Between 1995 and 2000 we treated 11 patients with benign symmetrical lipomatosis in the head and neck. The group comprised 10 men and one woman aged 34 to 62 years (mean 47). The most common complaints were reduced range of movement of the head and obstruction when eating or speaking. Combined lipectomy and liposuction were done for all patients, with liposuction being done at a second session. The mean follow-up period was 2.7 years. The functional results were satisfactory in all patients. Nine of the 11 patients were also satisfied with the aesthetic outcome. Two patients developed recurrence 1.5 and 2 years after the operation, respectively. There were no serious complications. We think that combined lipectomy and liposuction is a successful procedure for treating benign symmetrical lipomatosis in the head and neck region. Nevertheless, the advantages and drawbacks of the two techniques should be considered preoperatively.

Benign symmetrical lipomatosis (BSL) is a disease characterized by massively symmetrical fat deposits predominantly in the neck and shoulder girdle area. The disease is frequently associated with alcoholism, hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors. We describe a patient with BSL of the dorsal surfaces of both hands.

Benign symmetrical lipomatosis (BSL) is a rare disease characterized by symmetrical deposition of adipose tissue in the neck and upper trunk. Deltoid region and upper arm fatty deposits are rarely found and involvement below the torso is very uncommon. 1 The disorder was first mentioned by Brodie in 1846 and Madelung published details of a series of 33 cases in 1888. 2 Launois and Bensaude established BSL as a unique clinical entity in 1898. 3 The disorder occurs in both sexes, but is most commonly found in middle-aged men. The condition has been referred to as Madelung's disease, Launois and Bensaude syndrome, Buschke's disease, lipoma diffusa symmetrica, and benign symmetrical lipomatosis. 4 The report describes a case with involvement of the upper mediastinum and growth retardation.

Multiple symmetrical lipomatosis (Madelung’s disease) is a rare disease with multiple symmetrical unencapsulated fatty accumulation diffusely involving the neck, the shoulders and the upper extremities (Kohan et al. Otolaryngol. Head Neck Surg. 1993;108:156–159). We describe a 48-year-old Japanese man with a history of alcoholism and liver cirrhosis who reported gradually enlarging masses in his cervical region for 4 years. MRI revealed large masses suggesting lipomas in the neck. The patient underwent a two-stage lipectomy. This patient is the 13th case reported in Japan since 1978, though over 200 cases have been reported since 1846 in Europe, most of them from the Mediterranean (Kitano et al. ORL 1994;56:177–180; Kaku et al. Endocrinol. Diabetol. 1997;4:103–106).

Benign symmetric lipomatosis (BSL), also known as Madelung's disease, is a rare condition and characterized by diffuse but painless growth of unencapsulated lipomas. A close correlation to alcohol and nicotine abuse, metabolic disturbances and malignant tumours have been observed. Surgical treatment is frequently followed by recurrence, nevertheless, it can yield satisfactory functional and cosmetic results. A case of BSL with uncommonly distributed tumors is reported.

We present a patient who had benign symmetrical lipomatosis. He was treated surgically (6 operations), and the results were satisfactory. we discuss various factors in this disease and suggest the possibility of a nonsurgical treatment being developed in the future.

Benign symmetrical lipomatosis (BSL) that is a subgroup of benign lipomatosis disease is rare in the oral region. We recently experienced a case of macroglossia caused by BSL. The patient, a 71 year old man, came to our department with complaints of swallowing, eating and speech disorders by macroglossia. This case was diagnosied as symmetrical macroglossia. Glossectomy was performed under general anesthesia in order to improve these function disorders.It was diagnosised histologically because of its diffuse invasion of lipoid tissue.

Three patients with multiple nodular (encapsulated) lipomatosis and alcoholic cirrhosis of the liver are described. This association has not been previously reported. By contrast, the syndrome of diffuse nonencapsulated lipomatosis with cervical predominance (Launois-Bensaude Disease or Madelung Neck) has frequently occurred in association with alcoholism and cirrhosis of the liver.