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2. Prognostic impact of positive microscopic margins (R1 resection) in patients with GIST (gastrointestinal stromal tumours): Results of a multicenter European study

Author

Thibaut, Flore, Veziant, Julie, Warlaumont, Maxime, Gauthier, Victoria, Lefèvre, Jérémie, Gronnier, Caroline, Bonnet, Stephane, Mabrut, Jean-Yves, Regimbeau, Jean-Marc, Benhaim, Léonor, Tiberio, G.A.M., Mathonnet, Muriel, Regenet, Nicolas, Chirica, Mircea, Glehen, Olivier, Mariani, Pascale, Panis, Yves, Genser, Laurent, Mutter, Didier, Théreaux, Jérémie, Bergeat, Damien, Le Roy, Bertrand, Brigand, Cécile, Eveno, Clarisse, and Guillaume, Piessen

Published
2024
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5. Detection of Microsatellite Instability in Colorectal Cancer Tissue and Plasma samples using a new Multiplex Droplet Digital PCR kit

Author

Evrard, Camille, primary, Chaba, Kariman, additional, Abdelli, Justine, additional, Garinet, Simon, additional, Blons, Helene, additional, Zaanan, Aziz, additional, Bachet, Jean-Baptiste, additional, Benhaim, Leonor, additional, Mulot, Claire, additional, Didelot, Audrey, additional, Le Corre, Delphine, additional, Lukban, Jerianne, additional, Yin, Jennifer, additional, Corner, Adama, additional, Ho, Mai, additional, Taly, Valerie, additional, Tougeron, David, additional, and Laurent-Puig, Pierre, additional

Published
2024
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6. Management of Pathogenic CDH1 Variant Carriers Within the FREGAT Network: A Multicentric Retrospective Study

Author

Bres, Capucine, Voron, Thibault, Benhaim, Leonor, Bergeat, Damien, Parc, Yann, Karoui, Mehdi, Genser, Laurent, Pe[Combining Acute Accent]re[Combining Acute Accent], Guillaume, Demma, Jonathan A., Bacoeur-Ouzillou, Ophe[Combining Acute Accent]lie, Lebreton, Gil, Thereaux, Jeremie, Gronnier, Caroline, Dartigues, Peggy, Svrcek, Magali, Bouzille[Combining Acute Accent], Guillaume, Bardier, Armelle, Brunac, Anne C., Roche, Brigitte, Darcha, Claude, Bazille, Celine, Doucet, Laurent, Belleannee, Genevieve, Lejeune, Sophie, Buisine, Marie P., Renaud, Florence, Nuytens, Frederiek, Benusiglio, Patrick R., Veziant, Julie, Eveno, Clarisse, and Piessen, Guillaume

Published
2022
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7. Advanced colonic cancer with clinically suspected bladder invasion: Outcomes and prognosis from a multicentric study of 117 patients from the FRENCH research group

Author

Arfa, Sara, Dumont, Paul-Noël, Boullenois, Hortense, Fuks, David, Ouaissi, Mehdi, Benhaim, Leonor, Selvy, Marie, Tuech, Jean-Jacques, Lakkis, Zaher, Lupinacci, Renato, Epin, Antoine, Deguelte, Sophie, Passot, Guillaume, Trilling, Bertrand, Jarlot-Gas, Cécile, Mathonnet, Muriel, Moszkowicz, David, M’Harzi, Leila, Beyer Berjot, Laura, Vuillermet, Cindy, Meillat, Hélène, Manceau, Gilles, Creavin, Ben, Eveno, Clarisse, Benoist, Stéphane, Parc, Yann, and Lefevre, Jérémie H.

Published
2020
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9. Metastatic colorectal cancer (mCRC): French intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFR)

Author

Phelip, Jean Marc, Tougeron, David, Léonard, David, Benhaim, Leonor, Desolneux, Grégoire, Dupré, Aurélien, Michel, Pierre, Penna, Christophe, Tournigand, Christophe, Louvet, Christophe, Christou, Nikki, Chevallier, Patrick, Dohan, Anthony, Rousseaux, Benoist, and Bouché, Olivier

Published
2019
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11. Peritoneal Metastases

Author

Goéré, Diane, Dartigues, Peggy, Caramella, Caroline, Benhaim, Léonor, Honoré, Charles, Elias, Dominique, de Santibañes, Eduardo, editor, Ardiles, Victoria, editor, Alvarez, Fernando A., editor, Busnelli, Virginia Cano, editor, and de Santibañes, Martin, editor

Published
2017
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16. Supplementary Materials and Methods from The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models

Author

Ning, Yan, primary, Labonte, Melissa J., primary, Zhang, Wu, primary, Bohanes, Pierre O., primary, Gerger, Armin, primary, Yang, Dongyun, primary, Benhaim, Leonor, primary, Paez, David, primary, Rosenberg, David O., primary, Nagulapalli Venkata, Kalyan C., primary, Louie, Stan G., primary, Petasis, Nicos A., primary, Ladner, Robert D., primary, and Lenz, Heinz-Josef, primary

Published
2023
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17. Supplementary Figure 2 from The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models

Author

Ning, Yan, primary, Labonte, Melissa J., primary, Zhang, Wu, primary, Bohanes, Pierre O., primary, Gerger, Armin, primary, Yang, Dongyun, primary, Benhaim, Leonor, primary, Paez, David, primary, Rosenberg, David O., primary, Nagulapalli Venkata, Kalyan C., primary, Louie, Stan G., primary, Petasis, Nicos A., primary, Ladner, Robert D., primary, and Lenz, Heinz-Josef, primary

Published
2023
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18. Supplementary Figure 3 from The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models

Author

Ning, Yan, primary, Labonte, Melissa J., primary, Zhang, Wu, primary, Bohanes, Pierre O., primary, Gerger, Armin, primary, Yang, Dongyun, primary, Benhaim, Leonor, primary, Paez, David, primary, Rosenberg, David O., primary, Nagulapalli Venkata, Kalyan C., primary, Louie, Stan G., primary, Petasis, Nicos A., primary, Ladner, Robert D., primary, and Lenz, Heinz-Josef, primary

Published
2023
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19. Supplementary Figure 1 from The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models

Author

Ning, Yan, primary, Labonte, Melissa J., primary, Zhang, Wu, primary, Bohanes, Pierre O., primary, Gerger, Armin, primary, Yang, Dongyun, primary, Benhaim, Leonor, primary, Paez, David, primary, Rosenberg, David O., primary, Nagulapalli Venkata, Kalyan C., primary, Louie, Stan G., primary, Petasis, Nicos A., primary, Ladner, Robert D., primary, and Lenz, Heinz-Josef, primary

Published
2023
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20. Data from The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models

Author

Ning, Yan, primary, Labonte, Melissa J., primary, Zhang, Wu, primary, Bohanes, Pierre O., primary, Gerger, Armin, primary, Yang, Dongyun, primary, Benhaim, Leonor, primary, Paez, David, primary, Rosenberg, David O., primary, Nagulapalli Venkata, Kalyan C., primary, Louie, Stan G., primary, Petasis, Nicos A., primary, Ladner, Robert D., primary, and Lenz, Heinz-Josef, primary

Published
2023
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21. Data from Pharmacogenetic Angiogenesis Profiling for First-line Bevacizumab plus Oxaliplatin-Based Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Gerger, Armin, primary, El-Khoueiry, Anthony, primary, Zhang, Wu, primary, Yang, Dongyun, primary, Singh, Harpreet, primary, Bohanes, Pierre, primary, Ning, Yan, primary, Winder, Thomas, primary, LaBonte, Melissa J., primary, Wilson, Peter M., primary, Benhaim, Leonor, primary, Paez, David, primary, El-Khoueiry, Rita, primary, Absenger, Gudrun, primary, and Lenz, Heinz-Josef, primary

Published
2023
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22. Supplementary Table 1 from Pharmacogenetic Angiogenesis Profiling for First-line Bevacizumab plus Oxaliplatin-Based Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Gerger, Armin, primary, El-Khoueiry, Anthony, primary, Zhang, Wu, primary, Yang, Dongyun, primary, Singh, Harpreet, primary, Bohanes, Pierre, primary, Ning, Yan, primary, Winder, Thomas, primary, LaBonte, Melissa J., primary, Wilson, Peter M., primary, Benhaim, Leonor, primary, Paez, David, primary, El-Khoueiry, Rita, primary, Absenger, Gudrun, primary, and Lenz, Heinz-Josef, primary

Published
2023
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23. Iatrogenic ureteral injury during colorectal surgery has a significant impact on patient outcomes: a French multicentric retrospective cohort study

Author

Sérénon, Victor, Rouanet, Philippe, Charleux-Muller, Diane, Eveno, Clarisse, Poirot, Karine, Trilling, Bertrand, Benoist, Stéphane, Manceau, Gilles, Panis, Yves, Alves, Arnaud, Kartheuser, Alex, Venara, Aurélien, Pocard, Marc, Sabbagh, Charles, Laforest, Anaïs, Lakkis, Zaher, Badic, Bogdan, Chau, Amélie, Christou, Niki, Beyer-Berjot, Laura, Dumont, Frederic, Germain, Adeline, Valverde, Alain, Duchalais, Emilie, Ouaissi, Mehdi, Benhaim, Leonor, Collard, Maxime, Tuech, Jean‐jacques, Buscail, Etienne, Mege, Diane, Régimbeau, Jean-Marc, Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), CRLC Val d'Aurelle-Paul Lamarque, CRLCC Val d'Aurelle - Paul Lamarque, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Grenoble, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Service de Chirurgie Viscérale et Digestive [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Caen Normandie - UFR Santé (UNICAEN Santé), Normandie Université (NU)-Normandie Université (NU), Université Catholique de Louvain = Catholic University of Louvain (UCL), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), CArcinose Péritoine Paris-Technologies (ex-CART) (CAP Paris-Tech (UMR_S_1275)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Chirurgie digestive [CHU Amiens], CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Traitement de l'Information Medicale (LaTIM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Contrôle de l’Activation Cellulaire, Progression Tumorale et Résistance thérapeutique (CAPTuR), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, and The French Research Group of Rectal Cancer Surgery = Groupe de Recherche en Chirurgie du Rectum (GRECCAR)

Subjects
ureteral injury, colorectal surgery, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, chemotherapy, ureteral stent
Abstract

International audience; Aim: The long-term urological sequelae after iatrogenic ureteral injury (IUI) during colorectal surgery are not clearly known. The aims of this work were to report the incidence of IUI and to analyse the long-term consequences of urological late complications and their impact on oncological results of IUI occurring during colorectal surgery through a French multicentric experience (GRECCAR group).Method: All the patients who presented with IUI during colorectal surgery between 2010 and 2019 were retrospectively included. Patients with ureteral involvement needing en bloc resection, delayed ureteral stricture or noncolorectal surgery were not considered.Results: A total of 202 patients (93 men, mean age 63 ± 14 years) were identified in 29 centres, corresponding to 0.32% of colorectal surgeries (n = 63 562). Index colorectal surgery was mainly oncological (n = 130, 64%). IUI was diagnosed postoperatively in 112 patients (55%) after a mean delay of 11 ± 9 days. Intraoperative diagnosis of IUI was significantly associated with shorter length of stay (21 ± 22 days vs. 34 ± 22 days, p < 0.0001), lower rates of postoperative hydronephrosis (2% vs. 10%, p = 0.04), anastomotic complication (7% vs. 22.5%, p = 0.002) and thromboembolic event (0% vs. 6%, p = 0.02) than postoperative diagnosis of IUI. Delayed chemotherapy because of IUI was reported in 27% of patients. At the end of the follow-up [3 ± 2.6 years (1 month-13 years)], 72 patients presented with urological sequalae (36%). Six patients (3%) required a nephrectomy.Conclusion: IUI during colorectal surgery has few consequences for the patients if recognized early. Long-term urological sequelae can occur in a third of patients. IUI may affect oncological outcomes in colorectal surgery by delaying adjuvant chemotherapy, especially when the ureteral injury is not diagnosed peroperatively.

Published
2023

25. Is liquid biopsy useful in patients with GI malignancies and exclusive peritoneal disease?

Author

Smolenschi, Cristina, primary, Valery, Marine, additional, Boileve, Alice, additional, Cervantes, Baptiste, additional, Tarabay, Anthony, additional, Boige, Valerie, additional, Ben-Ammar, Imen, additional, Cheaib, Bianca, additional, Gelli, Maximiliano, additional, Sourouille, Isabelle, additional, Benhaim, Leonor, additional, Fuerea, Alina, additional, Perret, Audrey, additional, Ducreux, Michel, additional, and Hollebecque, Antoine, additional

Published
2023
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27. Associations between the severity of medical and surgical complications and perception of surgeon empathy in esophageal and gastric cancer patients

Author

Gehenne, Lucie, Lelorain, Sophie, Eveno, Clarisse, Piessen, Guillaume, Mariette, Christophe, Glehen, Olivier, d'Journo, Xavier, Mathonnet, Muriel, Regenet, Nicolas, Meunier, Bernard, Baudry, Anne-Sophie, Christophe, Véronique, Adenis, Antoine, Aparicio, Thomas, Assenat, Eric, Barret, Maximilien, Benhaim, Leonor, Benoit, Céline, Bergeat, Damien, Boige, Valérie, Borie, Fréderic, Bouche, Olivier, Bourriez, Damien, Brichon, Pierre-Yves, Brigand, Cécile, Carrere, Nicolas, Cattan, Pierre, Christou, Niki, Coffin, Benoit, Cohen, Romain, Collet, Denis, Conroy, Thierry, Dahan, Laetitia, Deguelte, Sophie, Di Fiore, Fréderic, Dousset, Bertrand, Drouillard, Antoine, Dumont, Frédéric, Elhajbi, Farid, Fabre, Jean Michel, Fabre, Joseph, Gagniere, Johan, Galais, Marie Pierre, Germain, Adeline, Geyl, Sophie, Goere, Diane, Gornet, Jean Marc, Granger, Victoire, Gronnier, Caroline, Guimbaud, Rosine, Hautefeuille, Vincent, Helyon, Morgane, Jougon, Jacques, Lebreton, Gilles, Lefevre, Jérémie, Lepage, Côme, Lievre, Astrid, Marchal, Frédéric, Mathieu, Pierre, Mathysiak, Tamara, Michot, Nicolas, Moszkowicz, David, Moussata, Driffa, Msika, Simon, Neuzillet, Cindy, Ouaissi, Medhi, Paquette, Brice, Paye, François, Penna, Christophe, Père, Guillaume, Perrier, Marine, Peschaud, Frédérique, Pezet, Denis, Phoutthsang, Valérie, Pocard, Marc, Rat, Paul, Regimbeau, Jean Marc, Renaud, Florence, Sabate, Jean-Marc, Souche, Régis, Terrebonne, Eric, Tessier, Williams, Thomas, Pascal Alexandre, Turpin, Anthony, Vaudoyer, Delphine, Vienot, Angélique, Voron, Thibault, You, Benoit, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pontchaillou [Rennes], Centre hospitalier [Valenciennes, Nord], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Esophageal Neoplasms, media_common.quotation_subject, education, [SDV.CAN]Life Sciences [q-bio]/Cancer, Empathy, MESH: Perception, Odds, Postoperative complications, MESH: Surgeons, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Perception, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Major complication, Retrospective Studies, Cancer, media_common, Multinomial logistic regression, Surgeons, Physician-Patient Relations, MESH: Humans, business.industry, Nursing research, MESH: Retrospective Studies, Cognition, MESH: Stomach Neoplasms, medicine.disease, Patient-physician communication, MESH: Empathy, Oncology, 030220 oncology & carcinogenesis, MESH: Esophageal Neoplasms, MESH: Physician-Patient Relations, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Objective: To assess the impact of global physician empathy and its three subdimensions (establishing rapport, emotional and cognitive processes) on the severity of postoperative complications in a sample of cancer patients.Methods: We retrospectively analyzed data on 256 patients with esogastric cancer from the French national FREGAT database. Empathy and its subdimensions were assessed using the patient-reported CARE scale and the severity of medical and surgical complications was reported with the Clavien-Dindo classification system. The usual covariates were included in multinomial logistic regression analyses.Results: Physician empathy predicted the odds of reporting major complications. When patients perceived high empathy, they were less likely to report major complications compared to no complications (OR = .95, 95% CI = [.91-.99], p = .029). Among the three dimensions, only "establishing rapport" (OR = .84, 95% CI = [.73-.98], p = .019) and the "emotional process" (OR = .85, 95% CI = [.74-.98], p = .022) predicted major complications.Conclusions: Physician empathy is essential before surgery. Further research is needed to understand the mechanisms associating empathy with health outcomes in cancer. Physicians should be trained to establish good rapport with patients, especially in the preoperative period.

Published
2021

29. Prognostic Value of Fusobacterium nucleatum after Abdominoperineal Resection for Anal Squamous Cell Carcinoma

Author

Hilmi, Marc, primary, Neuzillet, Cindy, additional, Lefèvre, Jérémie H., additional, Svrcek, Magali, additional, Vacher, Sophie, additional, Benhaim, Leonor, additional, Dartigues, Peggy, additional, Samalin, Emmanuelle, additional, Lazartigues, Julien, additional, Emile, Jean-François, additional, Rigault, Eugénie, additional, Rioux-Leclercq, Nathalie, additional, de La Fouchardière, Christelle, additional, Tougeron, David, additional, Cacheux, Wulfran, additional, Mariani, Pascale, additional, Courtois, Laura, additional, Delaye, Matthieu, additional, Dangles-Marie, Virginie, additional, Lièvre, Astrid, additional, and Bieche, Ivan, additional

Published
2022
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30. Circadian Rhythm and Circulating Cell-Free DNA Release on Healthy Subjects

Author

Poulet, Geoffroy, primary, Hulot, Jean-Sébastien, additional, Blanchard, Anne, additional, Bergerot, Damien, additional, Xiao, Wenjin, additional, Ginot, Frederic, additional, Boutonnet-Rodat, Audrey, additional, Beinse, Guillaume, additional, Geromel, Vanna, additional, Pellegrina, Laurence, additional, Azizi, Michel, additional, Laurent-Puig, Pierre, additional, Benhaim, Leonor, additional, and Taly, Valerie, additional

Published
2022
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31. Oxaliplatin in metastatic colorectal cancer: Does hepatic arterial infusion reduce sensitive neuropathy compared to the intravenous route?

Author

Valery, Marine, primary, Tanguy, Marie Laure, additional, Boige, Valérie, additional, Smolenschi, Cristina, additional, Hollebecque, Antoine, additional, Fuerea, Alina, additional, Klotz-Prieux, Caroline, additional, Benhaim, Leonor, additional, Debaere, Thierry, additional, Gelli, Maximiliano, additional, Tselikas, Lambros, additional, Ducreux, Michel, additional, and Malka, David, additional

Published
2022
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32. Circulating tumor DNA is a prognostic marker of tumor recurrence in stage II and III colorectal cancer: multicentric, prospective cohort study (ALGECOLS)

Author

Benhaim, Leonor, primary, Bouché, Olivier, additional, Normand, Corinne, additional, Didelot, Audrey, additional, Mulot, Claire, additional, Le Corre, Delphine, additional, Garrigou, Sonia, additional, Djadi-Prat, Juliette, additional, Wang-Renault, Shu-Fang, additional, Perez-Toralla, Karla, additional, Pekin, Deniz, additional, Poulet, Geoffroy, additional, Landi, Bruno, additional, Taieb, Julien, additional, Selvy, Marie, additional, Emile, Jean-Francois, additional, Lecomte, Thierry, additional, Blons, Helene, additional, Chatellier, Gilles, additional, Link, Darren R., additional, Taly, Valerie, additional, and Laurent-Puig, Pierre, additional

Published
2021
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33. Characterization of Plasma Cell-Free DNA Integrity Using Droplet-Based Digital PCR: Toward the Development of Circulating Tumor DNA-Dedicated Assays

Author

Poulet, Geoffroy, Garlan, Fanny, Garrigou, Sonia, Zonta, Eleonora, Benhaim, Leonor, Carrillon, Marie-Jennifer, Didelot, Audrey, Le Corre, Delphine, Mulot, Claire, Nizard, Philippe, GINOT, Frederic, Boutonnet-Rodat, Audrey, Blons, Helene, Bachet, Jean-Baptiste, Taïeb, Julien, Zaanan, Aziz, Geromel, Vanna, Pellegrina, Laurence, Laurent-Puig, Pierre, Wang-Renault, Shu-Fang, Taly, Valérie, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique (MEPPOT - U1147), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Gustave Roussy (IGR), Département de chirurgie viscérale [Gustave Roussy], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Adelis Technologies, Service d'oncologie médicale [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Eurofins Biomnis, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Gestionnaire, HAL Sorbonne Université 5

Subjects
circulating tumor DNA, DNA integrity index, Cancer Research, picoliter-droplet digital PCR, [SDV.CAN] Life Sciences [q-bio]/Cancer, Oncology, apoptosis, [SDV.CAN]Life Sciences [q-bio]/Cancer, circulating cell-free DNA, Original Research, cancer biomarker, necrosis
Abstract

International audience; Background: Cellular-cell free-DNA (ccfDNA) is being explored as a diagnostic and prognostic tool for various diseases including cancer. Beyond the evaluation of the ccfDNA mutational status, its fragmentation has been investigated as a potential cancer biomarker in several studies. However, probably due to a lack of standardized procedures dedicated to preanalytical and analytical processing of plasma samples, contradictory results have been published. Methods: ddPCR assays allowing the detection of KRAS wild-type and mutated sequences ( KRAS p.G12V, pG12D, and pG13D) were designed to target different fragments sizes. Once validated on fragmented and non-fragmented DNA extracted from cancer cell lines, these assays were used to investigate the influence of the extraction methods on the non-mutated and mutated ccfDNA integrity reflected by the DNA integrity index (DII). The DII was then analyzed in two prospective cohorts of metastatic colorectal cancer patients (RASANC study n = 34; PLACOL study n = 12) and healthy subjects ( n = 49). Results and Discussion: Our results demonstrate that ccfDNA is highly fragmented in mCRC patients compared with healthy individuals. These results strongly suggest that the characterization of ccfDNA integrity hold great promise toward the development of a universal biomarker for the follow-up of mCRC patients. Furthermore, they support the importance of standardization of sample handling and processing in such analysis.

Published
2021

35. Advanced colonic cancer with clinically suspected bladder invasion: Outcomes and prognosis from a multicentric study of 117 patients from the FRENCH research group

Author

Vuillermet, Cindy, primary, Meillat, Hélène, additional, Manceau, Gilles, additional, Creavin, Ben, additional, Eveno, Clarisse, additional, Benoist, Stéphane, additional, Parc, Yann, additional, Lefevre, Jérémie H., additional, Arfa, Sara, additional, Dumont, Paul-Noël, additional, Boullenois, Hortense, additional, Fuks, David, additional, Ouaissi, Mehdi, additional, Benhaim, Leonor, additional, Selvy, Marie, additional, Tuech, Jean-Jacques, additional, Lakkis, Zaher, additional, Lupinacci, Renato, additional, Epin, Antoine, additional, Deguelte, Sophie, additional, Passot, Guillaume, additional, Trilling, Bertrand, additional, Jarlot-Gas, Cécile, additional, Mathonnet, Muriel, additional, Moszkowicz, David, additional, M’Harzi, Leila, additional, and Beyer Berjot, Laura, additional

Published
2020
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36. KRAS mutation detection trap. Letters

Author

Benhaim, Leonor, K., Maley, Le Corre, Delphine, Blons, Helene, Taly, Valérie, Bibeau, Frederique, Emile, Jean Francois, Laurent Puig, Pierre, Bases moléculaires de la réponse aux xénobiotiques (U775 (IFR95)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service d'anatomie pathologique [CHU Ambroise-Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], UMR S775, Université Paris Descartes - Paris 5 (UPD5), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Service d'anatomie pathologique, and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

37. Abstract 5235: Circulating tumor DNA as a prognostic marker in colorectal cancer: Preliminary results of a prospective trial

Author

Laurent-Puig, Pierre, primary, Bouché, Olivier, additional, Niarra, Ralph, additional, Aucouturier, Pascaline, additional, Benhaim, Leonor, additional, Landi, Bruno, additional, Berger, Anne, additional, Lecomte, Thierry, additional, Normand, Corinne, additional, Le Corre, Delphine, additional, Didelot, Audrey, additional, Mallet, Karine, additional, Perez Toralla, Karla, additional, Hor, Thevy, additional, El Harrak, Zakaria, additional, Chatellier, Gilles, additional, Hutchison, Brian, additional, Link, Darren, additional, and Taly, Valerie, additional

Published
2015
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38. Genetic variants of kinases suppressors of Ras (KSR) to predict tumor response to first-line cetuximab in patients with mCRC: Prospective analysis in the FIRE 3 trial.

Author

Benhaim, Leonor, primary, Zhang, Wu, additional, Wakatsuki, Takeru, additional, Gerger, Armin, additional, Yang, Dongyun, additional, Paez, David, additional, Ning, Yan, additional, El-Khoueiry, Rita Elie, additional, Loupakis, Fotios, additional, Bohanes, Pierre Oliver, additional, Stintzing, Sebastian, additional, Heinemann, Volker, additional, and Lenz, Heinz-Josef, additional

Published
2015
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40. ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma

Author

Laforest, Anais, primary, Aparicio, Thomas, additional, Zaanan, Aziz, additional, Silva, Fabio Pittella, additional, Didelot, Audrey, additional, Desbeaux, Aurélien, additional, Le Corre, Delphine, additional, Benhaim, Leonor, additional, Pallier, Karine, additional, Aust, Daniela, additional, Pistorius, Steffen, additional, Blons, Hélène, additional, Svrcek, Magali, additional, and Laurent-Puig, Pierre, additional

Published
2014
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41. Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients

Author

Taly, Valerie, primary, Pekin, Deniz, primary, Benhaim, Leonor, primary, Kotsopoulos, Steve K, primary, Le Corre, Delphine, primary, Li, Xinyu, primary, Atochin, Ivan, primary, Link, Darren R, primary, Griffiths, Andrew D, primary, Pallier, Karine, primary, Blons, Hélène, primary, Bouché, Olivier, primary, Landi, Bruno, primary, Hutchison, J Brian, primary, and Laurent-Puig, Pierre, primary

Published
2013
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43. Prospective Validation of Candidate SNPs of VEGF/VEGFR Pathway in Metastatic Colorectal Cancer Patients Treated with First-Line FOLFIRI Plus Bevacizumab

Author

Loupakis, Fotios, primary, Cremolini, Chiara, additional, Yang, Dongyun, additional, Salvatore, Lisa, additional, Zhang, Wu, additional, Wakatsuki, Takeru, additional, Bohanes, Pierre, additional, Schirripa, Marta, additional, Benhaim, Leonor, additional, Lonardi, Sara, additional, Antoniotti, Carlotta, additional, Aprile, Giuseppe, additional, Graziano, Francesco, additional, Ruzzo, Annamaria, additional, Lucchesi, Sara, additional, Ronzoni, Monica, additional, De Vita, Ferdinando, additional, Tonini, Giuseppe, additional, Falcone, Alfredo, additional, and Lenz, Heinz-Josef, additional

Published
2013
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45. Abstract 4211: Detection and quantification of minoritary subclones of KRAS in metastatic colorectal cancers by digital microfluidics: therapeutic implications.

Author

Pekin, Deniz, primary, Normand, Corinne, additional, Kotsopoulos, Steve, additional, Xinyu, Li, additional, Benhaim, Leonor, additional, Bouche, O., additional, Lecomte, T., additional, Le Corre, D., additional, Hor, T., additional, El Harrak, Z., additional, Nizard, P., additional, LINK, D., additional, HUTCHISON, B., additional, LAURENT-PUIG, P., additional, and Taly, Valerie, additional

Published
2013
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46. Gender specific profiling in SCN1A polymorphisms and time to recurrence in patients with stage II/III colorectal cancer.

Author

Benhaim, Leonor, primary, Gerger, Armin, additional, Bohanes, Pierre Oliver, additional, Paez, David, additional, Wakatsuki, Takeru, additional, Yang, Dongyun, additional, Labonte, Melissa Janae, additional, Zhang, Wu, additional, Ning, Yan, additional, Loupakis, Fotios, additional, El-Khoueiry, Rita, additional, Laurent-Puig, Pierre, additional, and Lenz, Heinz-Josef, additional

Published
2013
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47. The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models

Author

Ning, Yan, primary, Labonte, Melissa J., additional, Zhang, Wu, additional, Bohanes, Pierre O., additional, Gerger, Armin, additional, Yang, Dongyun, additional, Benhaim, Leonor, additional, Paez, David, additional, Rosenberg, David O., additional, Nagulapalli Venkata, Kalyan C., additional, Louie, Stan G., additional, Petasis, Nicos A., additional, Ladner, Robert D., additional, and Lenz, Heinz-Josef, additional

Published
2012
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48. Prognostic value of lemur tyrosine kinase-3 (LMTK3) polymorphism in Japanese (J) patients (PTS) with localized gastric adenocarcinoma (GAC).

Author

Barzi, Afsaneh, primary, Wakatsuki, Takeru, additional, Zhang, Wu, additional, Yang, Dongyun, additional, Loupakis, Fotios, additional, Ning, Yan, additional, El-Khoueiry, Rita, additional, Labonte, Melissa Janae, additional, Azuma, Mizutomo, additional, Bohanes, Pierre Oliver, additional, Benhaim, Leonor, additional, Gerger, Armin, additional, Koizumi, Wasaburo, additional, Watanabe, Masahiko, additional, Stebbing, Justin, additional, Giamas, Georgios, additional, and Lenz, Heinz-Josef, additional

Published
2012
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49. Ethnic gene profile of genes involved in angiogenesis to predict regional bevacizumab efficacy difference in gastric cancer.

Author

Wakatsuki, Takeru, primary, Zhang, Wu, additional, Yang, Dongyun, additional, Loupakis, Fotios, additional, Azuma, Mizutomo, additional, Gerger, Armin, additional, Graziano, Francesco, additional, Ning, Yan, additional, Labonte, Melissa Janae, additional, El-Khoueiry, Rita, additional, Bohanes, Pierre Oliver, additional, Benhaim, Leonor, additional, Páez, David, additional, Watanabe, Masahiko, additional, Koizumi, Wasaburo, additional, and Lenz, Heinz-Josef, additional

Published
2012
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50. Association of genetic variants in obesity-related genes with tumor recurrence in stage II/III colon cancer.

Author

Ladner, Robert D., primary, Gerger, Armin, additional, Zhang, Wu, additional, Labonte, Melissa Janae, additional, Yang, Dongyun, additional, Lenz, Felicitas, additional, Lenz, Cosima, additional, Bohanes, Pierre Oliver, additional, Ning, Yan, additional, Winder, Thomas, additional, Wilson, Peter M.D., additional, Benhaim, Leonor, additional, El-Khoueiry, Rita, additional, El-Khoueiry, Anthony B., additional, Iqbal, Syma, additional, and Lenz, Heinz-Josef, additional

Published
2012
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