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1. Modelling UX Ori Star Eclipses based on Spectral Observations with the Nordic Optical Telescope. I. RR Tau

Author

Grinin, V. P., Tambovtseva, L. V., Djupvik, A. A., Gahm, G., Grenman, T., Weber, H., Bengtsson, H., De Angelis, H., Duszanowicz, G., Heinonen, D., Holmberg, G., Karlsson, T., Larsson, M., Warell, J., and Wikander, T.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Based on observations obtained with the Nordic Optical Telescope we investigate the spectral variability of the Herbig Ae star RR Tau. This star belongs to the UX Ori family, characterized by very deep fadings caused by the screening of the star with opaque fragments (clouds) of the protoplanetary discs. At the moments of such minima one observes strong spectral variability due to the fact that the dust cloud occults, for an observer, not only the star but also a part of the region where the emission spectrum originates. We calculated a series of obscuration models to interpret the observed variability of the H-alpha line parameters. We consider two main obscuration scenarios: (1) the dust screen rises vertically above the circumstellar disc, and (2) the screen intersects the line-of-sight moving azimuthally with the disc. In both cases the model of the emission region consists of a compact magnetosphere and a magneto-centrifugal disc wind. Comparison with observations shows that the first scenario explains well the variability of the radiation flux, the equivalent width, as well as the asymmetry of the H-alpha line during eclipses, while the second scenario explains them only partly. This permits us to suggest that in the case of RR Tau, the main causes of the eclipses are either a structured disc wind, or the charged dust lifted along the field lines of the poloidal component of the magnetic field of the circumstellar disc., Comment: 16 pages, 17 figures

Published
2023
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2. Modelling UX Ori star eclipses based on spectral observations with the Nordic Optical Telescope − I. RR Tau

Author

Grinin, V P, primary, Tambovtseva, L V, additional, Djupvik, A A, additional, Gahm, G, additional, Grenman, T, additional, Weber, H, additional, Bengtsson, H, additional, De Angelis, H, additional, Duszanowicz, G, additional, Heinonen, D, additional, Holmberg, G, additional, Karlsson, T, additional, Larsson, M, additional, Warell, J, additional, and Wikander, T, additional

Published
2023
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4. Influence of the COVID-19 Lockdown and Restart on the Injury Incidence and Injury Burden in Men's Professional Football Leagues in 2020: The UEFA Elite Club Injury Study.

Author

Waldén, M, Ekstrand, J, Hägglund, M, McCall, A, Davison, M, Hallén, A, Bengtsson, H, Waldén, M, Ekstrand, J, Hägglund, M, McCall, A, Davison, M, Hallén, A, and Bengtsson, H

Abstract

BACKGROUND: Studies on football and the coronavirus disease 2019 (COVID-19) have mainly focused on the lockdown consequences for player fitness, the resumption of football training, and how to safely restart the league play, but injury data are scarce. OBJECTIVE: To describe the injury incidence and injury burden in men's professional football teams during the pandemic year of 2020. METHODS: Nineteen teams in 12 countries prospectively registered data on player-exposure and time-loss injuries throughout 2020. All major football leagues were paused as a direct response to the pandemic in March 2020 and were thereafter completely cancelled or restarted after a lockdown interval of at least two months. Historical data from 43 teams in the same cohort during the five preceding years (2015-2019) were used as reference. Between-season and within-season comparisons were made for injury incidence (number of injuries per 1000 h) and injury burden (number of absence days per 1000 h) with 95% confidence intervals and interquartile ranges. RESULTS: There was no increased match injury incidence or injury burden following the restart in 2020 compared with other time periods of 2020 and the corresponding periods 2015-2019. There was an increased training injury incidence and injury burden immediately during the lockdown in 2020, and they remained elevated also following the restart, being higher in 2020 compared with 2015-2019, respectively. The injury characteristics during the first months of the new 2020/21 season (August/September-December) were similar between the five teams that cancelled their 2019/20 season in March 2020 and the 14 teams that restarted their season in May/June 2020. CONCLUSIONS: There was no increased match injury incidence or injury burden following the COVID-19 lockdown and restart of the football season in 2020, but training injury incidence and injury burden were elevated and higher than in 2015-2019.

Published
2022

20. Tracing Medieval and Renaissance Alabaster Works of Art Back to Quarries: A Multi-Isotope (Sr, S, O) Approach

Author

Kloppmann, Wolfram, Leroux, Lise, Bromblet, Philippe, Guerrot, Catherine, Proust, Eric, Cooper, A.H., Worley, N., Smeds, S. A., Bengtsson, H., Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Centre de Recherche pour la Conservation des Collections (CRCC), Centre de Recherche sur la Conservation (CRC ), Muséum national d'Histoire naturelle (MNHN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Centre Interdisciplinaire de Conservation et Restauration du Patrimoine (CICRP), Ministère de la Culture et de la Communication (MCC), British Geological Survey (BGS), Geological Survey of Sweden, and sgu

Subjects
Oxygen, Sulphur, Isotopes, Strontium, Provenance, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Sculpture, Alabaster, Multi-Isotope Tracing, Forensics
Abstract

International audience; Multi-isotope fingerprinting (sulphur, oxygen and strontium isotopes) has been tested to study the provenances of medieval and Renaissance French and Swedish alabaster works of art. Isotope signatures of historical English, French and Spanish alabaster source quarries or areas are revealed to be highly specific, with a strong intra-group homogeneity and strong inter-group contrasts, especially for Sr and S isotopes. The chosen combination of isotope tracers is a good basis for forensic work on alabaster provenance, allowing verification of hypotheses about historical trade routes as well as identification of fakes and their origin. The applied analytical techniques of continuous flow isotope ratio mass spectrometry (CF-IRMS) and thermal ionization mass spectrometry (TIMS) only require micro-samples in the low-milligram range, thus minimizing the impact on the works of art.

Published
2014

21. Comparison of the Particle Flow in qq-g and qq-γ Events in e^+e^- Annihilation

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Cain, M. P., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Maruyama, K., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yamauchi, M., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Cain, M. P., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Maruyama, K., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yamauchi, M., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：108名

Published
2015

22. Measurement of the Photon Structure Function F2γ(x,Q2) in the region 0.2<Q2<7 GeV2

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., 藤井, 忠男, Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellett, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., van Uitert, B., VanDalen, G. J., van Daalen Wetters, R. F., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. C. S., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Fujii, T., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., 藤井, 忠男, Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellett, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., van Uitert, B., VanDalen, G. J., van Daalen Wetters, R. F., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. C. S., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Fujii, T., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：108名

Published
2015

23. Study of Baryon Correlations in e^+e^- Annihilation at 29 GeV

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：108名

Published
2015

24. Measurement of the Inclusive Branching Fraction τ^-→ντπ^-π^0+Neutral Meson(s)

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yamauchi, M., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yamauchi, M., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：109名

Published
2015

25. Measurement of tau Branching Ratios

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Bakken, J. A., Barbaro-Galtieri, A., Barker, A. R., Barnes, A.V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Chien, C. -Y., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Edberg, T. K., Eberhard, P. H., Eisner, A. M., 榎本, 良治, Erne, F. C., 藤井, 忠男, Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X-Q., Lynch, G. R., Madansky, L., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellett, D. E., Pevsner, A., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., van Uitert, B., VanDalen, G. J., van Daalen Wetters, R. F., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. C. S., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W-M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Fujii, T., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Bakken, J. A., Barbaro-Galtieri, A., Barker, A. R., Barnes, A.V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Chien, C. -Y., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Edberg, T. K., Eberhard, P. H., Eisner, A. M., 榎本, 良治, Erne, F. C., 藤井, 忠男, Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X-Q., Lynch, G. R., Madansky, L., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellett, D. E., Pevsner, A., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., van Uitert, B., VanDalen, G. J., van Daalen Wetters, R. F., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. C. S., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W-M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Fujii, T., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：112名

Published
2015

26. Experimental Limit on the Decay τ^-→ντK^-K0

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Kamae, T., Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Kamae, T., Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., and Takahashi, Tadayuki

Abstract

著者人数：108名

Published
2015

27. Pion and Kaon Pair Production in Photon-Photon Collisions

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Blumenfeld, B. J., Bobbink, G. J., Bross, A. D., Buchanan, C. D., Buijs, A., Cain, M. P., Caldwell, D. O., Chamberlain, O., Chien, C. -Y., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gabioud, B., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Joshi, U. P., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X.-Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Maruyama, K., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Pellett, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Sauerwein, R. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., van Tyen, R., van Uitert, B., VanDalen, G. J., van Daalen Wetters, R. F., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. C. S., Wolf, Z. R., Yamamoto, H., Yamauchi, M., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Blumenfeld, B. J., Bobbink, G. J., Bross, A. D., Buchanan, C. D., Buijs, A., Cain, M. P., Caldwell, D. O., Chamberlain, O., Chien, C. -Y., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gabioud, B., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Joshi, U. P., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X.-Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Maruyama, K., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Pellett, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Sauerwein, R. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., van Tyen, R., van Uitert, B., VanDalen, G. J., van Daalen Wetters, R. F., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. C. S., Wolf, Z. R., Yamamoto, H., Yamauchi, M., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：113名

Published
2015

28. Evidence for a Spin-One Particle Produced by Two Photons

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H-U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., 釜江, 常好, Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, Winston, Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X. -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellet, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., Van Uitert, B., Vandalen, G. J., van Daalen Wetters, R. R., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. S. C., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W. -M., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：108名

Published
2015

29. f1(1285) Formation in Photon-Photon Fusions Reactions

Author

TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnett, B. A., Bauer, D. A., Bay, A., Bengtsson, H-U., Bobbink, G. J., Buchanan, C. D., Buijs, A., Caldwell, D. O., Chao, H-Y., Chun, S-B., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Daoudi, M., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fairfield, K. H., Hauptman, J. M., Hofmann, W., Hylen, J., 釜江, 常好, Kaye, H. S., Kenney, R. W., Khacheryan, S., Kofler, R. R., Langeveld, W. G. J., Layter, J. G., Lin, W. T., Linde, F. L., Loken, S. C., Lu, A., Lynch, G. R., Madaras, R. J., Magnuson, B. D., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Miller, E. S., Moses, W., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, S. K., Pellett, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stephens, R. W., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Toutounchi, S., Van Tyen, R., Van Dalen, G. J., Vernon, W., Wagner, W., Wang, E. M., Wang, Y-X., Wenzel, W. A., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., Takahashi, Tadayuki, TPC/Two-Gamma Collaboration, 相原, 博昭, Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnett, B. A., Bauer, D. A., Bay, A., Bengtsson, H-U., Bobbink, G. J., Buchanan, C. D., Buijs, A., Caldwell, D. O., Chao, H-Y., Chun, S-B., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Daoudi, M., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., 榎本, 良治, Erne, F. C., Fairfield, K. H., Hauptman, J. M., Hofmann, W., Hylen, J., 釜江, 常好, Kaye, H. S., Kenney, R. W., Khacheryan, S., Kofler, R. R., Langeveld, W. G. J., Layter, J. G., Lin, W. T., Linde, F. L., Loken, S. C., Lu, A., Lynch, G. R., Madaras, R. J., Magnuson, B. D., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Miller, E. S., Moses, W., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, S. K., Pellett, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stephens, R. W., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., 高橋, 忠幸, Toutounchi, S., Van Tyen, R., Van Dalen, G. J., Vernon, W., Wagner, W., Wang, E. M., Wang, Y-X., Wenzel, W. A., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., TPC/Two-Gamma Collaboration, Aihara, H., Enomoto, R., Kamae, T., and Takahashi, Tadayuki

Abstract

著者人数：85名

Published
2015

30. Measurement of the photon structure functionF 2γ(x, Q2) in the region 0.2<Q 2<7 GeV2

Author

Aihara, H., Alston-Garnjost, M., Avery, R. E., Barbaro-Galtieri, A., Barker, A. R., Barnes, A. V., Barnett, B. A., Bauer, D. A., Bengtsson, H. -U., Bintinger, D. L., Bobbink, G. J., Bolognese, T. S., Bross, A. D., Buchanan, C. D., Buijs, A., Caldwell, D. O., Clark, A. R., Cowan, G. D., Crane, D. A., Dahl, O. I., Derby, K. A., Eastman, J. J., Eberhard, P. H., Edberg, T. K., Eisner, A. M., Enomoto, R., Erné, F. C., Fujii, T., Gary, J. W., Gorn, W., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Kamae, T., Kaye, H. S., Kees, K. H., Kenney, R. W., Kerth, L. T., Ko, W., Koda, R. I., Kofler, R. R., Kwong, K. K., Lander, R. L., Langeveld, W. G. J., Layter, J. G., Linde, F. L., Lindsey, C. S., Loken, S. C., Lu, A., Lu, X -Q., Lynch, G. R., Madaras, R. J., Maeshima, K., Magnuson, B. D., Marx, J. N., Masek, G. E., Mathis, L. G., Matthews, J. A. J., Maxfield, S. J., Melnikoff, S. O., Miller, E. S., Moses, W., McNeil, R. R., Nemethy, P., Nygren, D. R., Oddone, P. J., Paar, H. P., Park, D. A., Park, S. K., Pellett, D. E., Pripstein, M., Ronan, M. T., Ross, R. R., Rouse, F. R., Schwitkis, K. A., Sens, J. C., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Smith, J. R., Steinman, J. S., Stevenson, M. L., Stork, D. H., Strauss, M. G., Sullivan, M. K., Takahashi, T., Thompson, J. R., Toge, N., Toutounchi, S., van Tyen, R., van Uitert, B., VanDalen, G. J., van Daalen Wetters, R. F., Vernon, W., Wagner, W., Wang, E. M., Wang, Y. X., Wayne, M. R., Wenzel, W. A., White, J. T., Williams, M. C. S., Wolf, Z. R., Yamamoto, H., Yellin, S. J., Zeitlin, C., Zhang, W -M., and TPC/Two-Gamma Collaboration

Published
1987
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31. Tests of models for quark and gluon fragmentation ine + e − annihilation at $$\sqrt s = 29 GeV$$

Author

Aihara, H., Alston-Garnjost, M., Bakken, J. A., Barbaro-Galtieri, A., Barnes, A. V., Barnett, B. A., Bengtsson, H. -U., Blumenfeld, B. J., Bross, A. D., Buchanan, C. D., Chamberlain, O., Chien, C-Y., Clark, A. R., Cordier, A., Dahl, O. I., Day, C. T., Derby, K. A., Eberhard, P. H., Fancher, D. L., Fujii, H., Gabioud, B., Gary, J. W., Gorn, W., Hadley, N. J., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Kamae, T., Kaye, H. S., Kenney, R. W., Kerth, L. T., Koda, R. I., Kofler, R. R., Kwong, K. K., Layter, J. G., Lindsey, C. S., Loken, S. C., Lu, X. Q., Lynch, G. R., Madansky, L., Madaras, R. J., Maruyama, K., Marx, J. N., Matthews, J. A. J., Melnikoff, S. O., Moses, W., Nemethy, P., Nygren, D. R., Oddone, P. J., Park, D. A., Pevsner, A., Pripstein, M., Robrish, P. R., Ronan, M. T., Ross, R. R., Rouse, F. R., Sauerwein, R. R., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Stevenson, M. L., Stork, D. H., Ticho, H. K., Toge, N., van Daalen Wetters, R. F., Van Dalen, G. J., van Tyen, R., Wang, E. M., Wayne, M. R., Wenzel, W. A., Yamamoto, H., Yamauchi, M., and Zhang, W-M.

Published
1985
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32. Quark fragmentation functions and long-range correlations ine + e − annihilation at 29 GeV

Author

Aihara, H., Alston-Garnjost, M., Bakken, J. A., Barbaro-Galtieri, A., Barnes, A. V., Barnett, B. A., Bengtsson, H. -U., Blumenfeld, B. J., Bross, A. D., Buchanan, C. D., Chamberlain, O., Chien, C. -Y., Clark, A. R., Cordier, A., Dahl, O. I., Day, C. T., Derby, K. A., Eberhard, P. H., Fancher, D. L., Fujii, H., Fujii, T., Gabioud, B., Gary, J. W., Gorn, W., Hadley, N. J., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Kamae, T., Kaye, H. S., Kenney, R. W., Kerth, L. T., Koda, R. I., Kofler, R. R., Kwong, K. K., Layter, J. G., Lindsey, C. S., Loken, S. C., Lu, X. Q., Lynch, G. R., Madansky, L., Madaras, R. J., Maruyama, K., Marx, J. N., Matthews, J. A. J., Melnikoff, S. O., Moses, W., Nemethy, P., Nygren, D. R., Oddone, P. J., Park, D. A., Pevsner, A., Pripstein, M., Robrish, P. R., Ronan, M. T., Ross, R. R., Rouse, E. R., Sauerwein, R. R., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Stevenson, M. L., Stork, D. H., Ticho, H. K., Toge, N., van Daalen Wetters, R. F., Van Dalen, G. J., van Tyen, R., Wang, E. M., Wayne, M. R., Wenzel, W. A., Yamamoto, H., Yamauchi, M., and Zhang, W. -M.

Published
1985
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34. Inclusive γ and π0 production cross sections and energy fractions ine + e − annihilation at 29 GeV

Author

Aihara, H., Alston-Garnjost, M., Bakken, J. A., Barbaro-Galtieri, A., Barnes, A. V., Barnett, B. A., Bengtsson, H. -U., Blumenfeld, B. J., Bross, A. D., Buchanan, C. D., Chamberlain, O., Chiba, J., Chien, C-Y., Clark, A. R., Cordier, A., Dahl, O. I., Day, C. T., Derby, K. A., Eberhard, P. H., Fancher, D. L., Fujii, H., Fujii, T., Gabioud, B., Gary, J. W., Gorn, W., Hadley, N. J., Hauptman, J. M., Hofmann, W., Huth, J. E., Hylen, J., Iwasaki, H., Kamae, T., Kaye, H. S., Kenney, R. W., Kerth, L. T., Koda, R. I., Kofler, R. R., Kwong, K. K., Layter, J. G., Lindsey, C. S., Loken, S. C., Lu, X-Q., Lynch, G. R., Madansky, L., Madaras, R. J., Maruyama, K., Marx, J. N., Matthews, J. A. J., Melnikoff, S. O., Moses, W., Nemethy, P., Nygren, D. R., Oddone, P. J., Park, D. A., Pevsner, A., Pripstein, M., Robrish, P. R., Ronan, M. T., Ross, R. R., Rouse, F. R., Sauerwein, R. R., Shapiro, G., Shapiro, M. D., Shen, B. C., Slater, W. E., Stevenson, M. L., Stork, D. H., Ticho, H. K., Toge, N., van Daalen Wetters, R. F., van Dalen, G. J., van Tyen, R., Videau, H., Wang, E. M., Wayne, M. R., Wenzel, W. A., Yamamoto, H., Yamauchi, M., and Zhang, W-M.

Published
1985
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35. Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial

Author

Giora Pillar, Georg Dorffner, Thomas Penzel, Göran Hajak, Eleonora Chiossi, Birgit Högl, Heidi Danker-Hopfe, Petra Hoever, Bengtsson H, Olli Polo, Markku Partinen, Jasper Dingemanse, Yüksel Peker, Dieter Kunz, Bernd Saletu, Ulrich Hemmeter, Claudio L. Bassetti, Holsboer-Trachsler E, M.J. Barbanoj, Sören Berg, Josef Zeitlhofer, Ebrahim Io, Heike Benes, Department of Neurosciences, and Neurologian yksikkö

Subjects
Male, Receptors, Neuropeptide, Polysomnography, Pharmacology, Receptors, G-Protein-Coupled, 0302 clinical medicine, Orexin Receptors, Sleep Initiation and Maintenance Disorders, Acetamides, Hypnotics and Sedatives, Pharmacology (medical), Prospective Studies, 0303 health sciences, Cross-Over Studies, medicine.diagnostic_test, NARCOLEPSY, PEPTIDES, Middle Aged, Orexin receptor, 3. Good health, 317 Pharmacy, Anesthesia, Female, Sleep onset, Arousal, medicine.drug, Adult, WAKEFULNESS, DISORDERS, Endpoint Determination, education, FEEDING-BEHAVIOR, HYPOCRETIN OREXIN, 03 medical and health sciences, Double-Blind Method, medicine, Humans, Clinical Trials, METAANALYSIS, 030304 developmental biology, Psychiatric Status Rating Scales, Dose-Response Relationship, Drug, business.industry, Suvorexant, EFFICACY, medicine.disease, Isoquinolines, HYPNOTIC DRUGS, Crossover study, Orexin, Almorexant, business, REBOUND INSOMNIA, 030217 neurology & neurosurgery, Narcolepsy
Abstract

The orexin system is a key regulator of sleep and wakefulness. In a multicenter, double-blind, randomized, placebo-controlled, two-way crossover study, 161 primary insomnia patients received either the dual orexin receptor antagonist almorexant, at 400, 200, 100, or 50 mg in consecutive stages, or placebo on treatment nights at 1-week intervals. The primary end point was sleep efficiency (SE) measured by polysomnography; secondary end points were objective latency to persistent sleep (LPS), wake after sleep onset (WASO), safety, and tolerability. Dose-dependent almorexant effects were observed on SE , LPS , and WASO . SE improved significantly after almorexant 400 mg vs. placebo (mean treatment effect 14.4%; P < 0.001). LPS (–18 min (P = 0.02)) and WASO (–54 min (P < 0.001)) decreased significantly at 400 mg vs. placebo. Adverse-event incidence was dose-related. Almorexant consistently and dose-dependently improved sleep variables. The orexin system may offer a new treatment approach for primary insomnia.

Published
2012

37. Integrated genomic analyses of ovarian carcinoma

Author

Bell, D, Berchuck, A, Birrer, M, Chien, J, Cramer, DW, Dao, F, Dhir, R, DiSaia, P, Gabra, H, Glenn, P, Godwin, AK, Triche, T, Berman, BP, Van den Berg, DJ, Buckley, J, Baylin, SB, Zhang, J, Spellman, PT, Purdom, E, Iacocca, M, Shelton, T, Voet, D, Neuvial, P, Bengtsson, H, Jakkula, LR, Durinck, S, Han, J, Dorton, S, Marr, H, Zhang, H, Choi, YG, Wang, V, Wilkinson, J, Nguyen, H, Wang, NJ, Imielinski, M, Ngai, J, Conboy, JG, Parvin, B, Feiler, HS, Speed, TP, Gray, JW, Wu, CJ, Bloom, T, Levine, DA, Li, L, Socci, ND, Liang, Y, Taylor, BS, Kalloger, S, Schultz, N, Borsu, L, Lash, AE, Brennan, C, Ardlie, K, Viale, A, Shukla, S, Grimm, D, Sander, C, Ladanyi, M, Hoadley, KA, Meng, S, Du, Y, Karlan, BY, Shi, Y, Fennell, T, Cibulskis, K, Lawrence, MS, Meyerson, M, Hatfield, M, Mills, GB, Sivachenko, A, Jing, R, Park, RW, Liu, Y, Park, PJ, Ramos, AH, Noble, M, Chin, L, Carter, H, Kim, D, Morris, S, Winckler, W, Karchin, R, Morrison, C, Baldwin, J, Korkola, JE, Yena, P, Heiser, LM, Getz, G, Cho, RJ, Hu, Z, Gabriel, S, Mutch, D, Cerami, E, Rhodes, P, Olshen, A, Verhaak, RGW, Lander, ES, Reva, B, Antipin, Y, Shen, R, Olvera, N, Mankoo, P, Sheridan, R, Ciriello, G, Sherman, M, Chang, WK, Bernanke, JA, Hayes, DN, Carter, SL, Haussler, D, Orsulic, S, Benz, CC, Paulauskis, J, Stuart, JM, Zhang, N, Benz, SC, Sanborn, JZ, Vaske, CJ, Mermel, CH, Zhu, J, Szeto, C, Scott, GK, Yau, C, Rabeno, B, Ding, L, Park, K, Balu, S, Perou, CM, Saksena, G, Wilkerson, MD, Millis, S, Kahn, A, Turman, YJ, Fulton, RS, Onofrio, RC, Greene, JM, Sfeir, R, Jensen, MA, Chen, J, Whitmore, J, Alonso, S, Jordan, J, Chu, A, Rader, JS, Koboldt, DC, Zang, D, Gross, J, Barker, A, Compton, C, Eley, G, Ferguson, M, Fielding, P, Gerhard, DS, Myles, R, McLellan, MD, Schaefer, C, Helms, EB, Shaw, KRM, Sikic, BI, Vaught, J, Vockley, JB, Good, PJ, Guyer, MS, Ozenberger, B, Wylie, T, Peterson, J, Thomson, E, Smith-McCune, K, Sood, AK, Bowtell, D, Hubbard, D, Penny, R, Testa, JR, Chang, K, Walker, J, Dinh, HH, Drummond, JA, Fowler, G, Zhou, X, Gunaratne, P, Hawes, AC, Kovar, CL, Lewis, LR, Gupta, S, Morgan, MB, O'Laughlin, M, Newsham, IF, Santibanez, J, Reid, JG, Trevino, LR, Wu, J, Wu, Y-Q, Wang, M, Muzny, DM, Wheeler, DA, Gibbs, RA, Crenshaw, A, Sivachenko, AY, Topal, MD, Sougnez, C, Dooling, DJ, Fulton, L, Akbani, R, Abbott, R, Dees, ND, Zhang, Q, Kandoth, C, Wendl, M, Schierding, W, Shen, D, Harris, CC, Baggerly, KA, Schmidt, H, Wilson, RK, Kalicki, J, Delehaunty, KD, Fronick, CC, Demeter, R, Cook, L, Wallis, JW, Lin, L, Magrini, VJ, Yung, WK, Hodges, JS, Protopopov, A, Eldred, JM, Smith, SM, Pohl, CS, Vandin, F, Raphael, BJ, Weinstock, GM, Mardis, R, Kim, TM, Hartmann, L, Perna, I, Xiao, Y, Ren, G, Sathiamoorthy, N, Petrelli, N, Lee, E, Kucherlapati, R, Absher, DM, Huang, M, Waite, L, Sherlock, G, Brooks, JD, Li, JZ, Weinstein, JN, Xu, J, Myers, RM, Laird, PW, Cope, L, Herman, JG, Shen, H, Huntsman, DG, Weisenberger, DJ, Noushmehr, H, Pan, F, Massachusetts Institute of Technology. Department of Biology, Lander, Eric S., and Meyerson, Matthew L.

Subjects
endocrine system diseases, Serous carcinoma, Messenger, Gene Dosage, Cancer Genome Atlas Research Network, GYNECOLOGIC-ONCOLOGY-GROUP, GRADE SEROUS CARCINOMA, 0302 clinical medicine, Ovarian carcinoma, Aged, Carcinoma, DNA Methylation, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, MicroRNAs, Middle Aged, Mutation, Ovarian Neoplasms, RNA, Messenger, Genomics, Multidisciplinary, Genetics, HYBRID SELECTION, 0303 health sciences, female genital diseases and pregnancy complications, 3. Good health, Multidisciplinary Sciences, Serous fluid, BRCA MUTATION CARRIERS, 030220 oncology & carcinogenesis, DNA methylation, PARP inhibitor, Science & Technology - Other Topics, General Science & Technology, Biology, Article, 03 medical and health sciences, CLEAR-CELL CARCINOMA, MD Multidisciplinary, microRNA, HIGH-THROUGHPUT ANNOTATION, medicine, DRIVER MUTATIONS, Gene, 030304 developmental biology, Neoplastic, Science & Technology, MUTANT-CELLS, SOMATIC MUTATIONS, medicine.disease, CANCER STATISTICS, Gene Expression Regulation, Cancer research, RNA, Ovarian cancer
Abstract

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three microRNA subtypes, four promoter methylation subtypes and a transcriptional signature associated with survival duration, and shed new light on the impact that tumours with BRCA1/2 (BRCA1 or BRCA2) and CCNE1 aberrations have on survival. Pathway analyses suggested that homologous recombination is defective in about half of the tumours analysed, and that NOTCH and FOXM1 signalling are involved in serous ovarian cancer pathophysiology., National Institutes of Health (U.S.) (Grant U54HG003067), National Institutes of Health (U.S.) (Grant U54HG003273), National Institutes of Health (U.S.) (Grant U54HG003079), National Institutes of Health (U.S.) (Grant U24CA126543), National Institutes of Health (U.S.) (Grant U24CA126544), National Institutes of Health (U.S.) (Grant U24CA126546), National Institutes of Health (U.S.) (Grant U24CA126551), National Institutes of Health (U.S.) (Grant U24CA126554), National Institutes of Health (U.S.) (Grant U24CA126561), National Institutes of Health (U.S.) (Grant U24CA126563), National Institutes of Health (U.S.) (Grant U24CA143882), National Institutes of Health (U.S.) (Grant U24CA143731), National Institutes of Health (U.S.) (Grant U24CA143835), National Institutes of Health (U.S.) (Grant U24CA143845), National Institutes of Health (U.S.) (Grant U24CA143858), National Institutes of Health (U.S.) (Grant U24CA144025), National Institutes of Health (U.S.) (Grant U24CA143866), National Institutes of Health (U.S.) (Grant U24CA143867), National Institutes of Health (U.S.) (Grant U24CA143848), National Institutes of Health (U.S.) (Grant U24CA143843), National Institutes of Health (U.S.) (Grant R21CA135877)

Published
2010

38. DNA copy number analysis of fresh and formalin-fixed specimens by shallow whole-genome sequencing with identification and exclusion of problematic regions in the genome assembly

Author

Scheinin, I., Sie, D., Bengtsson, H., Wiel, M.A. van de, Olshen, A.B., Thuijl, H.F. van, Essen, H.F. van, Eijk, P.P., Rustenburg, F., Meijer, G.A., Reijneveld, J.C., Wesseling, P., Pinkel, D., Albertson, D.G., Ylstra, B., Scheinin, I., Sie, D., Bengtsson, H., Wiel, M.A. van de, Olshen, A.B., Thuijl, H.F. van, Essen, H.F. van, Eijk, P.P., Rustenburg, F., Meijer, G.A., Reijneveld, J.C., Wesseling, P., Pinkel, D., Albertson, D.G., and Ylstra, B.

Abstract

Contains fulltext : 139379.pdf (publisher's version ) (Open Access), Detection of DNA copy number aberrations by shallow whole-genome sequencing (WGS) faces many challenges, including lack of completion and errors in the human reference genome, repetitive sequences, polymorphisms, variable sample quality, and biases in the sequencing procedures. Formalin-fixed paraffin-embedded (FFPE) archival material, the analysis of which is important for studies of cancer, presents particular analytical difficulties due to degradation of the DNA and frequent lack of matched reference samples. We present a robust, cost-effective WGS method for DNA copy number analysis that addresses these challenges more successfully than currently available procedures. In practice, very useful profiles can be obtained with approximately 0.1x genome coverage. We improve on previous methods by first implementing a combined correction for sequence mappability and GC content, and second, by applying this procedure to sequence data from the 1000 Genomes Project in order to develop a blacklist of problematic genome regions. A small subset of these blacklisted regions was previously identified by ENCODE, but the vast majority are novel unappreciated problematic regions. Our procedures are implemented in a pipeline called QDNAseq. We have analyzed over 1000 samples, most of which were obtained from the fixed tissue archives of more than 25 institutions. We demonstrate that for most samples our sequencing and analysis procedures yield genome profiles with noise levels near the statistical limit imposed by read counting. The described procedures also provide better correction of artifacts introduced by low DNA quality than prior approaches and better copy number data than high-resolution microarrays at a substantially lower cost.

Published
2014

39. Tracing Medieval and Renaissance Alabaster Works of Art Back to Quarries: A Multi-Isotope (Sr, S, O) Approach

Author

Kloppmann, W., Leroux, L., Bromblet, P., Guerrot, C., Proust, E., Cooper, A.H., Worley, N., Smeds, S.-A., Bengtsson, H., Kloppmann, W., Leroux, L., Bromblet, P., Guerrot, C., Proust, E., Cooper, A.H., Worley, N., Smeds, S.-A., and Bengtsson, H.

Abstract

Multi-isotope fingerprinting (sulphur, oxygen and strontium isotopes) has been tested to study the provenances of medieval and Renaissance French and Swedish alabaster works of art. Isotope signatures of historical English, French and Spanish alabaster source quarries or areas are revealed to be highly specific, with a strong intra-group homogeneity and strong inter-group contrasts, especially for Sr and S isotopes. The chosen combination of isotope tracers is a good basis for forensic work on alabaster provenance, allowing verification of hypotheses about historical trade routes as well as identification of fakes and their origin. The applied analytical techniques of continuous flow isotope ratio mass spectrometry (CF–IRMS) and thermal ionization mass spectrometry (TIMS) only require micro-samples in the low-milligram range, thus minimizing the impact on the works of art.

Published
2014

40. Altered expression of myelin-associated inhibitors and their receptors after traumatic brain injury in the mouse

Author

Israelsson, C., Åstrand, Elaine, Kiwanuka, O., Bengtsson, H., Marklund, N., Israelsson, C., Åstrand, Elaine, Kiwanuka, O., Bengtsson, H., and Marklund, N.

Abstract

Purpose: When central nervous system axons are injured, regeneration is partly inhibited by myelin-associated inhibitors (MAIs). Following traumatic brain injury (TBI) in the rat, pharmacological neutralisation of the MAIs Nogo-A and myelin-associated glycoprotein (MAG) resulted in improved functional outcome. In contrast, genetic or pharmacological neutralization of the MAI receptors Nogo-66receptor 1 (NgR1) or paired-immunoglobulin like receptor-B (PirB) showed an unaltered or impaired outcome following TBI in mice. The aim of the present study was thus to evaluate the MAI expressionlevels following TBI in mice. Methods: Quantitative reverse transcriptase PCR (qRT-PCR) was used to measure total RNA isolated from brains of young adult male C57BL/6 mice at one, three or seven days following controlled cortical impact TBI or sham injury. Hippocampal and neocortical tissue ipsi- and contralateral to the injury was analyzed for Nogo-A, oligodendrocyte-myelin glycoprotein (OMgp), MAG, and the MAI receptors PirB and NgR1, including its co-receptor Lingo1. Results: Compared to sham-injured controls, PirB neocortical expression was significantly upregulated at one day and NgR1expression downregulated at seven days post-TBI. In the hippocampus, transcriptional upregulation was observed in Nogo-A (one day post-injury), MAG and PirB at seven days post-injury. In contrast, the hippocampal transcripts of NgR1 and Lingo1 were decreased at seven days post-injury. The expression of OMgp was unaltered at all time points post-injury. Conclusion: These results suggest that early dynamic changes in MAI gene expression occur following TBI in the mouse, particularly in the hippocampus, which may play an inhibitory role for post-injury regeneration and plasticity.

Published
2014
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43. illuminaio: An open source IDAT parsing tool for Illumina microarrays.

Author

Smith, ML, Baggerly, KA, Bengtsson, H, Ritchie, ME, Hansen, KD, Smith, ML, Baggerly, KA, Bengtsson, H, Ritchie, ME, and Hansen, KD

Abstract

The IDAT file format is used to store BeadArray data from the myriad of genomewide profiling platforms on offer from Illumina Inc. This proprietary format is output directly from the scanner and stores summary intensities for each probe-type on an array in a compact manner. A lack of open source tools to process IDAT files has hampered their uptake by the research community beyond the standard step of using the vendor's software to extract the data they contain in a human readable text format. To fill this void, we have developed the illuminaio package that parses IDAT files from any BeadArray platform, including the decryption of files from Illumina's gene expression arrays. illuminaio provides the first open-source package for this task, and will promote wider uptake of the IDAT format as a standard for sharing Illumina BeadArray data in public databases, in the same way that the CEL file serves as the standard for the Affymetrix platform.

Published
2013

44. The effect of extremely preterm birth on attachment organization in late adolescence

Author

Hallin, A-L, Bengtsson, H, Sepa Frostell, Anneli, Stjernqvist, K, Hallin, A-L, Bengtsson, H, Sepa Frostell, Anneli, and Stjernqvist, K

Abstract

Background Prior studies have examined the impact of preterm birth on the quality of the attachment relationship to the mother in infancy, but few have examined extremely preterm born infants and almost no data have been reported on prematurity and its impact on the attachment organization attained after childhood. less thanbrgreater than less thanbrgreater thanMethods Thirty-nine adolescents born extremely preterm and 39 full-term born control participants were assessed with the Adult Attachment Interview. less thanbrgreater than less thanbrgreater thanResults The prematurely born showed lower scores regarding measures of attachment security and, in particular, a higher proportion of insecure dismissive patterns. This difference seemed to be clear and persistent even when controlled for intelligence and socio-economic variables. less thanbrgreater than less thanbrgreater thanConclusions Because insecure attachment as well as prematurity may be considered as significant risk factors for developing psychopathology, they deserve careful attention in future research and clinical follow-ups., Funding Agencies|Linnea and Josef Carlsson Research Foundation||May Flower Foundation

Published
2012
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45. Copy Number Variation in Patients with Disorders of Sex Development Due to 46,XY Gonadal Dysgenesis

Author

Orban, L, White, S, Ohnesorg, T, Notini, A, Roeszler, K, Hewitt, J, Daggag, H, Smith, C, Turbitt, E, Gustin, S, van den Bergen, J, Miles, D, Western, P, Arboleda, V, Schumacher, V, Gordon, L, Bell, K, Bengtsson, H, Speed, T, Hutson, J, Warne, G, Harley, V, Koopman, P, Vilain, E, Sinclair, A, Orban, L, White, S, Ohnesorg, T, Notini, A, Roeszler, K, Hewitt, J, Daggag, H, Smith, C, Turbitt, E, Gustin, S, van den Bergen, J, Miles, D, Western, P, Arboleda, V, Schumacher, V, Gordon, L, Bell, K, Bengtsson, H, Speed, T, Hutson, J, Warne, G, Harley, V, Koopman, P, Vilain, E, and Sinclair, A

Abstract

Disorders of sex development (DSD), ranging in severity from mild genital abnormalities to complete sex reversal, represent a major concern for patients and their families. DSD are often due to disruption of the genetic programs that regulate gonad development. Although some genes have been identified in these developmental pathways, the causative mutations have not been identified in more than 50% 46,XY DSD cases. We used the Affymetrix Genome-Wide Human SNP Array 6.0 to analyse copy number variation in 23 individuals with unexplained 46,XY DSD due to gonadal dysgenesis (GD). Here we describe three discrete changes in copy number that are the likely cause of the GD. Firstly, we identified a large duplication on the X chromosome that included DAX1 (NR0B1). Secondly, we identified a rearrangement that appears to affect a novel gonad-specific regulatory region in a known testis gene, SOX9. Surprisingly this patient lacked any signs of campomelic dysplasia, suggesting that the deletion affected expression of SOX9 only in the gonad. Functional analysis of potential SRY binding sites within this deleted region identified five putative enhancers, suggesting that sequences additional to the known SRY-binding TES enhancer influence human testis-specific SOX9 expression. Thirdly, we identified a small deletion immediately downstream of GATA4, supporting a role for GATA4 in gonad development in humans. These CNV analyses give new insights into the pathways involved in human gonad development and dysfunction, and suggest that rearrangements of non-coding sequences disturbing gene regulation may account for significant proportion of DSD cases.

Published
2011

46. Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome.

Author

Jongmans, M.C.J., Kuiper, R.P., Carmichael, C.L., Wilkins, E.J., Dors, N., Carmagnac, A., Schouten-van Meeteren, A.Y., Li, X., Stankovic, M., Kamping, E.J., Bengtsson, H., Schoenmakers, E.F.P.M., Geurts van Kessel, A.H.M., Hoogerbrugge, P.M., Hahn, C.N., Brons, P.P.T., Scott, H.S., Hoogerbrugge-van der Linden, N., Jongmans, M.C.J., Kuiper, R.P., Carmichael, C.L., Wilkins, E.J., Dors, N., Carmagnac, A., Schouten-van Meeteren, A.Y., Li, X., Stankovic, M., Kamping, E.J., Bengtsson, H., Schoenmakers, E.F.P.M., Geurts van Kessel, A.H.M., Hoogerbrugge, P.M., Hahn, C.N., Brons, P.P.T., Scott, H.S., and Hoogerbrugge-van der Linden, N.

Abstract

1 januari 2010, Contains fulltext : 89885.pdf (publisher's version ) (Closed access)

Published
2010

47. TumorBoost: Normalization of allele-specific tumor copy numbers from a single pair of tumor-normal genotyping microarrays

Author

Bengtsson, H, Neuvial, P, Speed, TP, Bengtsson, H, Neuvial, P, and Speed, TP

Abstract

BACKGROUND: High-throughput genotyping microarrays assess both total DNA copy number and allelic composition, which makes them a tool of choice for copy number studies in cancer, including total copy number and loss of heterozygosity (LOH) analyses. Even after state of the art preprocessing methods, allelic signal estimates from genotyping arrays still suffer from systematic effects that make them difficult to use effectively for such downstream analyses. RESULTS: We propose a method, TumorBoost, for normalizing allelic estimates of one tumor sample based on estimates from a single matched normal. The method applies to any paired tumor-normal estimates from any microarray-based technology, combined with any preprocessing method. We demonstrate that it increases the signal-to-noise ratio of allelic signals, making it significantly easier to detect allelic imbalances. CONCLUSIONS: TumorBoost increases the power to detect somatic copy-number events (including copy-neutral LOH) in the tumor from allelic signals of Affymetrix or Illumina origin. We also conclude that high-precision allelic estimates can be obtained from a single pair of tumor-normal hybridizations, if TumorBoost is combined with single-array preprocessing methods such as (allele-specific) CRMA v2 for Affymetrix or BeadStudio's (proprietary) XY-normalization method for Illumina. A bounded-memory implementation is available in the open-source and cross-platform R package aroma.cn, which is part of the Aroma Project (http://www.aroma-project.org/).

Published
2010

48. A single-sample method for normalizing and combining full-resolution copy numbers from multiple platforms, labs and analysis methods

Author

Bengtsson, H, Ray, A, Spellman, P, Speed, TP, Bengtsson, H, Ray, A, Spellman, P, and Speed, TP

Abstract

MOTIVATION: The rapid expansion of whole-genome copy number (CN) studies brings a demand for increased precision and resolution of CN estimates. Recent studies have obtained CN estimates from more than one platform for the same set of samples, and it is natural to want to combine the different estimates in order to meet this demand. Estimates from different platforms show different degrees of attenuation of the true CN changes. Similar differences can be observed in CNs from the same platform run in different labs, or in the same lab, with different analytical methods. This is the reason why it is not straightforward to combine CN estimates from different sources (platforms, labs and analysis methods). RESULTS: We propose a single-sample multi source normalization that brings full-resolution CN estimates to the same scale across sources. The normalized CNs are such that for any underlying CN level, their mean level is the same regardless of the source, which make them better suited for being combined across sources, e.g. existing segmentation methods may be used to identify aberrant regions. We use microarray-based CN estimates from 'The Cancer Genome Atlas' (TCGA) project to illustrate and validate the method. We show that the normalized and combined data better separate two CN states at a given resolution. We conclude that it is possible to combine CNs from multiple sources such that the resolution becomes effectively larger, and when multiple platforms are combined, they also enhance the genome coverage by complementing each other in different regions. AVAILABILITY: A bounded-memory implementation is available in aroma.cn.

Published
2009

49. A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6

Author

Bengtsson, H, Wirapati, P, Speed, TP, Bengtsson, H, Wirapati, P, and Speed, TP

Abstract

MOTIVATION: High-resolution copy-number (CN) analysis has in recent years gained much attention, not only for the purpose of identifying CN aberrations associated with a certain phenotype, but also for identifying CN polymorphisms. In order for such studies to be successful and cost effective, the statistical methods have to be optimized. We propose a single-array preprocessing method for estimating full-resolution total CNs. It is applicable to all Affymetrix genotyping arrays, including the recent ones that also contain non-polymorphic probes. A reference signal is only needed at the last step when calculating relative CNs. RESULTS: As with our method for earlier generations of arrays, this one controls for allelic crosstalk, probe affinities and PCR fragment-length effects. Additionally, it also corrects for probe sequence effects and co-hybridization of fragments digested by multiple enzymes that takes place on the latest chips. We compare our method with Affymetrix's CN5 method and the dChip method by assessing how well they differentiate between various CN states at the full resolution and various amounts of smoothing. Although CRMA v2 is a single-array method, we observe that it performs as well as or better than alternative methods that use data from all arrays for their preprocessing. This shows that it is possible to do online analysis in large-scale projects where additional arrays are introduced over time.

Published
2009

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