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Human movements are impressively flexible and precise. They are also coloured by the characteristics with which each person performs an act. This is evident in everyday activities, in sports, in art, and in music performance. How does the human brain control a movement pattern and give it its character, given all possible degrees of freedom? In this thesis we have investigated the cortical organization of two fundamental aspects of sequential movements; the explicit temporal control of when to move, and the spatial control of where to move, with a particular focus on the temporal control. As model behaviour we have used sequence production with the fingers, and with functional resonance imaging we localized the associated neural activation. We measured the behaviour of the participants' rhythmic motor performance to enable interpretation of the brain activation. Finally, we studied the plasticity of the white matter as a function of practicing in pianists using diffusion tensor imaging. Firstly, we investigated if the relative timing and the ordinal sequence of spatial locations of a movement can be handled independently by the brain. We found evidence for a parallel processing of the two aspects. In study I, we found that once a rhythmic sequence is learned it can be executed with different spatial movement patterns with little extra training. In study II we showed that the two aspects mainly activate different brain regions. Processing the temporal information activated motor areas of the medial wall, the inferior frontal cortex, the temporal lobe, and the lateral cerebellum, whereas the ordinal sequencing activated the parietal cortex, the dorsal premotor cortex, the cerebellum and the putamen. In study III, we found that pianists use two parallel visual pathways to guide their movements when playing from written music. The dorsal visual stream appears to be involved in the spatial melody processing, whereas the ventral visual stream processes the rhythmical info