16 results on '"Beng Lee Lim"'
Search Results
2. Author Correction: Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
- Author
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Supaporn Wacharapluesadee, Chee Wah Tan, Patarapol Maneeorn, Prateep Duengkae, Feng Zhu, Yutthana Joyjinda, Thongchai Kaewpom, Wan Ni Chia, Weenassarin Ampoot, Beng Lee Lim, Kanthita Worachotsueptrakun, Vivian Chih-Wei Chen, Nutthinee Sirichan, Chanida Ruchisrisarod, Apaporn Rodpan, Kirana Noradechanon, Thanawadee Phaichana, Niran Jantarat, Boonchu Thongnumchaima, Changchun Tu, Gary Crameri, Martha M. Stokes, Thiravat Hemachudha, and Lin-Fa Wang
- Subjects
Science - Abstract
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21768-2
- Published
- 2021
- Full Text
- View/download PDF
3. SARS-CoV-2 Omicron variant emerged under immune selection
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Chee Wah Tan, Wan Ni Chia, Feng Zhu, Barnaby E. Young, Napaporn Chantasrisawad, Shi-Hsia Hwa, Aileen Ying-Yan Yeoh, Beng Lee Lim, Wee Chee Yap, Surinder Kaur M. S. Pada, Seow Yen Tan, Watsamon Jantarabenjakul, Lim Kai Toh, Shiwei Chen, Jinyan Zhang, Yun Yan Mah, Vivian Chih-Wei Chen, Mark I-C Chen, Supaporn Wacharapluesadee, Alex Sigal, Opass Putcharoen, David Chien Lye, and Lin-Fa Wang
- Subjects
Microbiology (medical) ,Membrane Glycoproteins ,SARS-CoV-2 ,Immunology ,COVID-19 ,Cell Biology ,Antibodies, Viral ,Applied Microbiology and Biotechnology ,Microbiology ,Viral Envelope Proteins ,Neutralization Tests ,Spike Glycoprotein, Coronavirus ,Genetics ,Animals ,Humans - Abstract
The SARS-CoV-2 Omicron variant (B.1.1.529 lineage) escapes antibodies that neutralize the ancestral virus. We tested human serum panels from participants with differing infection and vaccination status using a multiplex surrogate virus neutralization assay targeting 20 sarbecoviruses. We found that bat and pangolin sarbecoviruses showed significantly less neutralization escape than the Omicron variant. We propose that SARS-CoV-2 variants have emerged under immune selection pressure and are evolving differently from animal sarbecoviruses.
- Published
- 2022
4. Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5
- Author
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Chee-Wah Tan, Beng-Lee Lim, Barnaby E Young, Aileen Ying-Yan Yeoh, Chee-Fu Yung, Wee-Chee Yap, Thomas Althaus, Wan-Ni Chia, Feng Zhu, David Chien Lye, and Lin-Fa Wang
- Subjects
Microbiology (medical) ,Infectious Diseases ,SARS-CoV-2 ,Virology ,Humans ,COVID-19 ,Microbiology - Published
- 2022
5. Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecoviruses
- Author
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Lin-Fa Wang, Chee Wah Tan, Wan Ni Chia, Feng Zhu, Barnaby Young, Napaporn Chantasrisawad, Shi-Hsia Hwa, Aileen Ying-Yan Yeoh, Beng Lee Lim, Wee Chee Yap, Surinder Kaur Pada, Seow Yen Tan, Watsamon Jantarabenjakul, Shiwei Chen, Jinyan Zhang, Yun Yan Mah, Vivian Chen, Mark Chen, Supaporn Wacharapluesadee, COMMIT-KZN Team, Opass Putcharoen, and David Lye
- Subjects
skin and connective tissue diseases - Abstract
The SARS-CoV-2 B.1.1.529 lineage, Omicron variant, was first detected in November 2021 and carries 32 amino acid mutations in the spike protein (15 in RBD) and exhibits significant escape of neutralizing antibodies targeting the parental SARS-CoV-2 virus. Here, we performed a high-resolution multiplex (16-plex) surrogate virus neutralization assay covering all major SARS-CoV-2 variants and pre-emergent ACE2-binding sarbecoviruses against 20 different human serum panels from infected, vaccinated and hybrid immune individuals which had vaccine-breakthrough infections or infection followed by vaccination. Among all sarbecoviruses tested, we observed 1.1 to 4.7-, 2.3 to 10.3- and 0.7 to 33.3-fold reduction in neutralization activities to SARS-CoV-2 Beta, Omicron and SARS-CoV-1, respectively. Among the SARS-CoV-2 related sarbecoviruses, it is found that the genetically more distant bat RaTG13 and pangolin GX-P5L sarbecoviruses had less neutralization escape than Omicron. Our data suggest that the SARS-CoV-2 variants emerged from the changed immune landscape of human populations are more potent in escaping neutralizing antibodies, from infection or vaccination, than pre-emergent sarbecoviruses naturally evolved in animal populations with no or less immune selection pressure.
- Published
- 2022
6. Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors
- Author
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Yee Sin Leo, Lin-Fa Wang, David C. Lye, Wan-Ni Chia, Tun-Linn Thein, Beng-Lee Lim, Barnaby Edward Young, Wan-Rong Sia, Mark I-Cheng Chen, Feng Zhu, and Chee-Wah Tan
- Subjects
2019-20 coronavirus outbreak ,COVID-19 Vaccines ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Disease ,Antibodies, Viral ,Severe Acute Respiratory Syndrome ,Immunogenicity, Vaccine ,Medicine ,Humans ,Survivors ,BNT162 Vaccine ,Phylogeny ,B-Lymphocytes ,biology ,business.industry ,SARS-CoV-2 ,Immunogenicity ,COVID-19 ,General Medicine ,Virology ,Severe acute respiratory syndrome-related coronavirus ,biology.protein ,Original Article ,Severe acute respiratory syndrome coronavirus ,Antibody ,business ,Broadly Neutralizing Antibodies - Abstract
Summary Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a challenge to the effectiveness of current vaccines. A vaccine that could prevent infection caused by known and future variants of concern as well as infection with pre-emergent sarbecoviruses (i.e., those with potential to cause disease in humans in the future) would be ideal. Here we provide data showing that potent cross-clade pan-sarbecovirus neutralizing antibodies are induced in survivors of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) infection who have been immunized with the BNT162b2 messenger RNA (mRNA) vaccine. The antibodies are high-level and broad-spectrum, capable of neutralizing not only known variants of concern but also sarbecoviruses that have been identified in bats and pangolins and that have the potential to cause human infection. These findings show the feasibility of a pan-sarbecovirus vaccine strategy. (Funded by the Singapore National Research Foundation and National Medical Research Council.)
- Published
- 2021
7. Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
- Author
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Katarina Luko, Chee Wah Tan, Shailendra Mani, Zhengli Shi, Florent Ginhoux, Qian Zhang, Justin H. J. Ng, Wan Ni Chia, Aaron T. Irving, Danielle E. Anderson, Matae Ahn, Loo Chien Wang, Ming Wen, Beng Lee Lim, Charles-Antoine Dutertre, Radoslaw M. Sobota, and Lin-Fa Wang
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Microbiology (medical) ,0303 health sciences ,030306 microbiology ,Middle East respiratory syndrome coronavirus ,Immunology ,RNA ,Inflammasome ,Cell Biology ,Biology ,medicine.disease_cause ,Applied Microbiology and Biotechnology ,Microbiology ,Pyrin domain ,Virology ,Virus ,03 medical and health sciences ,Immune system ,Genetics ,medicine ,Influenza A virus ,Viral load ,030304 developmental biology ,medicine.drug - Abstract
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether these unique features are interlinked. The important inflammasome sensor, NLR family pyrin domain containing 3 (NLRP3), has been linked to both viral-induced and age-related inflammation. Here, we report significantly dampened activation of the NLRP3 inflammasome in bat primary immune cells compared to human or mouse counterparts. Lower induction of apoptosis-associated speck-like protein containing a CARD (ASC) speck formation and secretion of interleukin-1β in response to both 'sterile' stimuli and infection with multiple zoonotic viruses including influenza A virus (-single-stranded (ss) RNA), Melaka virus (PRV3M, double-stranded RNA) and Middle East respiratory syndrome coronavirus (+ssRNA) was observed. Importantly, this reduction of inflammation had no impact on the overall viral loads. We identified dampened transcriptional priming, a novel splice variant and an altered leucine-rich repeat domain of bat NLRP3 as the cause. Our results elucidate an important mechanism through which bats dampen inflammation with implications for longevity and unique viral reservoir status.
- Published
- 2019
8. Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
- Author
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Supaporn Wacharapluesadee, Thanawadee Phaichana, Lin-Fa Wang, Niran Jantarat, Changchun Tu, Thiravat Hemachudha, Thongchai Kaewpom, Yutthana Joyjinda, Apaporn Rodpan, Weenassarin Ampoot, Boonchu Thongnumchaima, Wan Ni Chia, Prateep Duengkae, Nutthinee Sirichan, Feng Zhu, Martha M. Stokes, Vivian Chih Wei Chen, Gary Crameri, Beng Lee Lim, Chanida Ruchisrisarod, Chee Wah Tan, Kirana Noradechanon, Kanthita Worachotsueptrakun, and Patarapol Maneeorn
- Subjects
0301 basic medicine ,Range (biology) ,viruses ,Science ,030106 microbiology ,Wildlife ,Zoology ,General Physics and Astronomy ,Receptors, Cell Surface ,Virus ,Article ,General Biochemistry, Genetics and Molecular Biology ,Rhinolophus malayanus ,03 medical and health sciences ,Protein Domains ,Phylogenetics ,Neutralization Tests ,Chiroptera ,Pandemic ,Animals ,Pangolins ,Amino Acid Sequence ,Rhinolophus acuminatus ,Author Correction ,Asia, Southeastern ,Phylogeny ,Multidisciplinary ,biology ,Geography ,SARS-CoV-2 ,Pangolin ,virus diseases ,COVID-19 ,General Chemistry ,biology.organism_classification ,Antibodies, Neutralizing ,030104 developmental biology ,Pathogens - Abstract
Among the many questions unanswered for the COVID-19 pandemic are the origin of SARS-CoV-2 and the potential role of intermediate animal host(s) in the early animal-to-human transmission. The discovery of RaTG13 bat coronavirus in China suggested a high probability of a bat origin. Here we report molecular and serological evidence of SARS-CoV-2 related coronaviruses (SC2r-CoVs) actively circulating in bats in Southeast Asia. Whole genome sequences were obtained from five independent bats (Rhinolophus acuminatus) in a Thai cave yielding a single isolate (named RacCS203) which is most related to the RmYN02 isolate found in Rhinolophus malayanus in Yunnan, China. SARS-CoV-2 neutralizing antibodies were also detected in bats of the same colony and in a pangolin at a wildlife checkpoint in Southern Thailand. Antisera raised against the receptor binding domain (RBD) of RmYN02 was able to cross-neutralize SARS-CoV-2 despite the fact that the RBD of RacCS203 or RmYN02 failed to bind ACE2. Although the origin of the virus remains unresolved, our study extended the geographic distribution of genetically diverse SC2r-CoVs from Japan and China to Thailand over a 4800-km range. Cross-border surveillance is urgently needed to find the immediate progenitor virus of SARS-CoV-2., A bat origin for SARS-CoV-2 has been proposed. Here, by sampling wild Rhinolophus acuminatus bats from Thailand, the authors identified a SARS-CoV-2-related coronavirus (SC2r-CoV), designated as RacCS203, with 91.5% genome similarity to SARS-CoV-2, and show that sera obtained from bats and Malayan pangolin neutralize SARS-CoV-2.
- Published
- 2020
9. Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
- Author
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Clarence C. Tam, Joey M.E. Lim, Louisa Jin Sun, Marina Zahari, Wei Yee Wan, Jenny G. Low, Anthony T. Tan, Lin-Fa Wang, Antonio Bertoletti, Yee-Joo Tan, Siew Hoon Lim, Nivedita Shankar, Christine Y.L. Tham, Beng Lee Lim, Charles-Antoine Dutertre, David C. Lye, Linda Wei Lin Tan, Wan Ni Chia, Zaw Myo Tun, Hannah E. Clapham, Li Yang Hsu, Kamini Kunasegaran, Jane Mingjie Lim, Adeline Chia, Nina Le Bert, Shirin Kalimuddin, Vishakha Kumar, and Paul A. Tambyah
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_treatment ,T cell ,viruses ,T-Lymphocytes ,Immunology ,Lymphocyte Activation ,Asymptomatic ,Article ,Proinflammatory cytokine ,Infectious Disease and Host Defense ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,medicine ,Immunology and Allergy ,Humans ,Seroconversion ,skin and connective tissue diseases ,Asymptomatic Infections ,business.industry ,SARS-CoV-2 ,ELISPOT ,fungi ,COVID-19 ,biochemical phenomena, metabolism, and nutrition ,Middle Aged ,body regions ,030104 developmental biology ,Cytokine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cytokines ,Cytokine secretion ,medicine.symptom ,business - Abstract
By using a rapid whole-blood T cell activation assay measuring cytokines released by SARS-CoV-2–specific T cells, Le Bert et al. show that individuals who clear SARS-CoV-2 infection without symptoms mount a highly functional virus-specific cellular immune response., The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2–specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied SARS-CoV-2–specific T cells in a cohort of asymptomatic (n = 85) and symptomatic (n = 75) COVID-19 patients after seroconversion. We quantified T cells reactive to structural proteins (M, NP, and Spike) using ELISpot and cytokine secretion in whole blood. Frequencies of SARS-CoV-2–specific T cells were similar between asymptomatic and symptomatic individuals, but the former showed an increased IFN-γ and IL-2 production. This was associated with a proportional secretion of IL-10 and proinflammatory cytokines (IL-6, TNF-α, and IL-1β) only in asymptomatic infection, while a disproportionate secretion of inflammatory cytokines was triggered by SARS-CoV-2–specific T cell activation in symptomatic individuals. Thus, asymptomatic SARS-CoV-2–infected individuals are not characterized by weak antiviral immunity; on the contrary, they mount a highly functional virus-specific cellular immune response., Graphical Abstract
- Published
- 2020
10. Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
- Author
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Jane Mingjie Lim, Hannah E. Clapham, Li Yang Hsu, Marina Zahari, Wan Ni Chia, Christine Y.L. Tham, Clarence C. Tam, Jenny G. Low, Nivedita Shankar, Yee-Joo Tan, Joey M.E. Lim, Antonio Bertoletti, David C. Lye, Zaw Myo Tun, Lin-Fa Wang, Louisa Jin Sun, Linda Wei Lin Tan, Anthony T. Tan, Kamini Kunasegaran, Wei Yee Wan, Paul A. Tambyah, Beng Lee Lim, Adeline Chia, Vishakha Kumar, Siew Hoon Lim, Shirin Kalimuddin, Nina Le Bert, and Charles-Antoine Dutertre
- Subjects
biology ,business.industry ,T cell ,ELISPOT ,Asymptomatic ,Proinflammatory cytokine ,medicine.anatomical_structure ,Immune system ,Immunology ,medicine ,biology.protein ,Cytokine secretion ,Tumor necrosis factor alpha ,medicine.symptom ,Antibody ,business - Abstract
The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between their antiviral and inflammatory features. SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 infection without symptoms or disease could reveal non-pathological yet protective characteristics. We therefore compared the quantity and function of SARS-CoV-2-specific T cells in a cohort of asymptomatic individuals (n=85) with that of symptomatic COVID-19 patients (n=76), at different time points after antibody seroconversion. We quantified T cells reactive to structural proteins (M, NP and Spike) using ELISpot assays, and measured the magnitude of cytokine secretion (IL-2, IFN-γ, IL-4, IL-6, IL-1β, TNF-α and IL-10) in whole blood following T cell activation with SARS-CoV-2 peptide pools as a functional readout. Frequencies of T cells specific for the different SARS-CoV-2 proteins in the early phases of recovery were similar between asymptomatic and symptomatic individuals. However, we detected an increased IFN-γ and IL-2 production in asymptomatic compared to symptomatic individuals after activation of SARS-CoV-2-specific T cells in blood. This was associated with a proportional secretion of IL-10 and pro-inflammatory cytokines (IL-6, TNF-α and IL-1β) only in asymptomatic infection, while a disproportionate secretion of inflammatory cytokines was triggered by SARS-CoV-2-specific T cell activation in symptomatic individuals. Thus, asymptomatic SARS-CoV-2 infected individuals are not characterized by a weak antiviral immunity; on the contrary, they mount a robust and highly functional virus-specific cellular immune response. Their ability to induce a proportionate production of IL-10 might help to reduce inflammatory events during viral clearance.
- Published
- 2020
11. Author Correction: Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
- Author
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Niran Jantarat, Supaporn Wacharapluesadee, Boonchu Thongnumchaima, Lin-Fa Wang, Patarapol Maneeorn, Martha M. Stokes, Thiravat Hemachudha, Vivian Chih Wei Chen, Yutthana Joyjinda, Wan Ni Chia, Prateep Duengkae, Weenassarin Ampoot, Thongchai Kaewpom, Chee Wah Tan, Apaporn Rodpan, Nutthinee Sirichan, Thanawadee Phaichana, Changchun Tu, Kanthita Worachotsueptrakun, Chanida Ruchisrisarod, Gary Crameri, Beng Lee Lim, Kirana Noradechanon, and Feng Zhu
- Subjects
2019-20 coronavirus outbreak ,Multidisciplinary ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Science ,General Physics and Astronomy ,General Chemistry ,Biology ,Virology ,General Biochemistry, Genetics and Molecular Biology ,Southeast asia - Abstract
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21768-2
- Published
- 2021
12. Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
- Author
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Matae, Ahn, Danielle E, Anderson, Qian, Zhang, Chee Wah, Tan, Beng Lee, Lim, Katarina, Luko, Ming, Wen, Wan Ni, Chia, Shailendra, Mani, Loo Chien, Wang, Justin Han Jia, Ng, Radoslaw M, Sobota, Charles-Antoine, Dutertre, Florent, Ginhoux, Zheng-Li, Shi, Aaron T, Irving, and Lin-Fa, Wang
- Subjects
Inflammasomes ,Interleukin-1beta ,Viral transmission ,Mice ,Protein Domains ,Influenza A virus ,Chiroptera ,Influenza, Human ,NLR Family, Pyrin Domain-Containing 3 Protein ,Middle East Respiratory Syndrome Coronavirus ,Animals ,Humans ,News & Views ,Coronavirus Infections ,Disease Reservoirs - Abstract
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether these unique features are interlinked. The important inflammasome sensor, NLR family pyrin domain containing 3 (NLRP3), has been linked to both viral-induced and age-related inflammation. Here, we report significantly dampened activation of the NLRP3 inflammasome in bat primary immune cells compared to human or mouse counterparts. Lower induction of apoptosis-associated speck-like protein containing a CARD (ASC) speck formation and secretion of interleukin-1β in response to both 'sterile' stimuli and infection with multiple zoonotic viruses including influenza A virus (-single-stranded (ss) RNA), Melaka virus (PRV3M, double-stranded RNA) and Middle East respiratory syndrome coronavirus (+ssRNA) was observed. Importantly, this reduction of inflammation had no impact on the overall viral loads. We identified dampened transcriptional priming, a novel splice variant and an altered leucine-rich repeat domain of bat NLRP3 as the cause. Our results elucidate an important mechanism through which bats dampen inflammation with implications for longevity and unique viral reservoir status.
- Published
- 2018
13. Developing Life Skills Through Math And Science Games
- Author
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Wee Khee Seah, Li Yang Ng, Ying Zhen Ang, Wenbin Reico Maynard Ng, Beng Lee Lim, Wee Khee Seah, Li Yang Ng, Ying Zhen Ang, Wenbin Reico Maynard Ng, and Beng Lee Lim
- Subjects
- Science--Study and teaching (Secondary)--Activity programs, Life skills--Study and teaching (Secondary)--Activity programs, Mathematics--Study and teaching (Secondary)--Activity programs
- Abstract
Shaping character and life skills for our leaders of tomorrow has always been a challenging task. This exciting new book brings a new perspective to educating our young in a fun, exciting and engaging manner. High energy games that bring about both breadth and depth of discussion by the participants will inevitably develop their innate leadership potential and competency levels over time. These games are designed to be logistically minimal so that all can enjoy the games at any time.
- Published
- 2013
14. Developing Life Skills Through Math and Science Games
- Author
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Wee Khee Seah, Li Yang Ng, Ying Zhen Ang, Reico Ng, and Beng Lee Lim
- Published
- 2012
15. Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor.
- Author
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Wan Ni Chia, Chee Wah Tan, Tan, Aaron Wai Kit, Young, Barnaby, Starr, Tyler N., Lopez, Ester, Fibriansah, Guntur, Barr, Jennifer, Cheng, Samuel, Yeoh, Aileen Ying-Yan, Wee Chee Yap, Beng Lee Lim, Thiam-Seng Ng, Wan Rong Sia, Feng Zhu, Shiwei Chen, Jinyan Zhang, Kwek, Madeline Sheng Si, Greaney, Allison J., and Chen, Mark
- Subjects
- *
MONOCLONAL antibodies , *SARS-CoV-2 , *FC receptors , *COVID-19 , *CLASSICAL swine fever - Abstract
The article focuses on a study conducted to characterize powerful monoclonal antibodies (mAbs) from a vaccinated severe acute respiratory syndrome coronavirus (SARS-CoV) survivor. It found that one specific mAb (E7) showed remarkable potency and coverage against huACE2-dependent sarbecoviruses, with unique binding characteristics revealed through mutagenesis and cryo-electron microscopy.
- Published
- 2023
- Full Text
- View/download PDF
16. Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors.
- Author
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Chee-Wah Tan, Wan-Ni Chia, Young, Barnaby E., Feng Zhu, Beng-Lee Lim, Wan-Rong Sia, Tun-Linn Thein, Chen, Mark l.-C., Yee-Sin Leo, Lye, David C., Lin-Fa Wang, Tan, Chee-Wah, Chia, Wan-Ni, Zhu, Feng, Lim, Beng-Lee, Sia, Wan-Rong, Thein, Tun-Linn, Chen, Mark I-C, Leo, Yee-Sin, and Wang, Lin-Fa
- Abstract
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a challenge to the effectiveness of current vaccines. A vaccine that could prevent infection caused by known and future variants of concern as well as infection with pre-emergent sarbecoviruses (i.e., those with potential to cause disease in humans in the future) would be ideal. Here we provide data showing that potent cross-clade pan-sarbecovirus neutralizing antibodies are induced in survivors of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) infection who have been immunized with the BNT162b2 messenger RNA (mRNA) vaccine. The antibodies are high-level and broad-spectrum, capable of neutralizing not only known variants of concern but also sarbecoviruses that have been identified in bats and pangolins and that have the potential to cause human infection. These findings show the feasibility of a pan-sarbecovirus vaccine strategy. (Funded by the Singapore National Research Foundation and National Medical Research Council.). [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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