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3. Non-resonant circles for strong magnetic fields on surfaces

Author

Asselle, L. and Benedetti, G.

Subjects
Mathematics - Dynamical Systems, Mathematics - Symplectic Geometry
Abstract

We study non-resonant circles for strong magnetic fields on a closed, connected, oriented surface and show how these can be used to prove the existence of trapping regions and of periodic magnetic geodesics with prescribed low speed. As a corollary, there exist infinitely many periodic magnetic geodesics for every low speed in the following cases: i) the surface is not the two-sphere, ii) the magnetic field vanishes somewhere., Comment: 13 Pages, Comments welcome

Published
2021

6. The Compact Linear Collider (CLIC) - 2018 Summary Report

Author

CLIC, The, collaborations, CLICdp, Charles, T. K., Giansiracusa, P. J., Lucas, T. G., Rassool, R. P., Volpi, M., Balazs, C., Afanaciev, K., Makarenko, V., Patapenka, A., Zhuk, I., Collette, C., Boland, M. J., Hoffman, A. C. Abusleme, Diaz, M. A., Garay, F., Chi, Y., He, X., Pei, G., Pei, S., Shu, G., Wang, X., Zhang, J., Zhao, F., Zhou, Z., Chen, H., Gao, Y., Huang, W., Kuang, Y. P., Li, B., Li, Y., Meng, X., Shao, J., Shi, J., Tang, C., Wang, P., Wu, X., Zha, H., Ma, L., Han, Y., Fang, W., Gu, Q., Huang, D., Huang, X., Tan, J., Wang, Z., Zhao, Z., Uggerhøj, U. I., Wistisen, T. N., Aabloo, A., Aare, R., Kuppart, K., Vigonski, S., Zadin, V., Aicheler, M., Baibuz, E., Brücken, E., Djurabekova, F., Eerola, P., Garcia, F., Haeggström, E., Huitu, K., Jansson, V., Kassamakov, I., Kimari, J., Kyritsakis, A., Lehti, S., Meriläinen, A., Montonen, R., Nordlund, K., Österberg, K., Saressalo, A., Väinölä, J., Veske, M., Farabolini, W., Mollard, A., Peauger, F., Plouin, J., Bambade, P., Chaikovska, I., Chehab, R., Delerue, N., Davier, M., Faus-Golfe, A., Irles, A., Kaabi, W., LeDiberder, F., Pöschl, R., Zerwas, D., Aimard, B., Balik, G., Blaising, J. -J., Brunetti, L., Chefdeville, M., Dominjon, A., Drancourt, C., Geoffroy, N., Jacquemier, J., Jeremie, A., Karyotakis, Y., Nappa, J. M., Serluca, M., Vilalte, S., Vouters, G., Bernhard, A., Bründermann, E., Casalbuoni, S., Hillenbrand, S., Gethmann, J., Grau, A., Huttel, E., Müller, A. -S., Peiffer, P., Perić, I., de Jauregui, D. Saez, Emberger, L., Graf, C., Simon, F., Szalay, M., van der Kolk, N., Brass, S., Kilian, W., Alexopoulos, T., Apostolopoulos, T., Gazis, E. N., Gazis, N., Kostopoulos, V., Kourkoulis, S., Heilig, B., Lichtenberger, J., Shrivastava, P., Dayyani, M. K., Ghasem, H., Hajari, S. S., Shaker, H., Ashkenazy, Y., Popov, I., Engelberg, E., Yashar, A., Abramowicz, H., Benhammou, Y., Borysov, O., Borysova, M., Levy, A., Levy, I., Alesini, D., Bellaveglia, M., Buonomo, B., Cardelli, A., Diomede, M., Ferrario, M., Gallo, A., Ghigo, A., Giribono, A., Piersanti, L., Stella, A., Vaccarezza, C., de Blas, J., Franceschini, R., D'Auria, G., Di Mitri, S., Abe, T., Aryshev, A., Fukuda, M., Furukawa, K., Hayano, H., Higashi, Y., Higo, T., Kubo, K., Kuroda, S., Matsumoto, S., Michizono, S., Naito, T., Okugi, T., Shidara, T., Tauchi, T., Terunuma, N., Urakawa, J., Yamamoto, A., Raboanary, R., Luiten, O. J., Stragier, X. F. D., Hart, R., van der Graaf, H., Eigen, G., Adli, E., Lindstrøm, C. A., Lillestøl, R., Malina, L., Pfingstner, J., Sjobak, K. N., Ahmad, A., Hoorani, H., Khan, W. A., Bugiel, S., Bugiel, R., Firlej, M., Fiutowski, T. A., Idzik, M., Moroń, J., Świentek, K. P., de Renstrom, P. Brückman, Krupa, B., Kucharczyk, M., Lesiak, T., Pawlik, B., Sopicki, P., Turbiarz, B., Wojtoń, T., Zawiejski, L. K., Kalinowski, J., Nowak, K., Żarnecki, A. F., Firu, E., Ghenescu, V., Neagu, A. T., Preda, T., Zgura, I. S., Aloev, A., Azaryan, N., Boyko, I., Budagov, J., Chizhov, M., Filippova, M., Glagolev, V., Gongadze, A., Grigoryan, S., Gudkov, D., Karjavine, V., Lyablin, M., Nefedov, Yu., Olyunin, A., Rymbekova, A., Samochkine, A., Sapronov, A., Shelkov, G., Shirkov, G., Soldatov, V., Solodko, E., Trubnikov, G., Tyapkin, I., Uzhinsky, V., Vorozhtov, A., Zhemchugov, A., Levichev, E., Mezentsev, N., Piminov, P., Shatilov, D., Vobly, P., Zolotarev, K., Jelisavčić, I. Božović, Kačarević, G., Dumbelović, G. Milutinović, Pandurović, M., Radulović, M., Stevanović, J., Vukasinović, N., Lee, D. -H., Ayala, N., Benedetti, G., Guenzel, T., Iriso, U., Marti, Z., Perez, F., Pont, M., Trenado, J., Ruiz-Jimeno, A., Vila, I., Calero, J., Dominguez, M., Garcia-Tabares, L., Gavela, D., Lopez, D., Toral, F., Gutierrez, C. Blanch, Boronat, M., Esperante, D., Fullana, E., Fuster, J., García, I., Gimeno, B., Lopez, P. Gomis, González, D., Perelló, M., Ros, E., Villarejo, M. A., Vnuchenko, A., Vos, M., Borgmann, Ch., Brenner, R., Ekelöf, T., Jacewicz, M., Olvegård, M., Ruber, R., Ziemann, V., Aguglia, D., Gonzalvo, J. Alabau, Leon, M. Alcaide, Tehrani, N. Alipour, Anastasopoulos, M., Andersson, A., Andrianala, F., Antoniou, F., Apyan, A., Arominski, D., Artoos, K., Assly, S., Atieh, S., Baccigalupi, C., Sune, R. Ballabriga, Caballero, D. Banon, Barnes, M. J., Garcia, J. Barranco, Bartalesi, A., Bauche, J., Bayar, C., Belver-Aguilar, C., Morell, A. Benot, Bernardini, M., Bett, D. R., Bettoni, S., Bettencourt, M., Bielawski, B., Garcia, O. Blanco, Kraljevic, N. Blaskovic, Bolzon, B., Bonnin, X. A., Bozzini, D., Branger, E., Brondolin, E., Brunner, O., Buckland, M., Bursali, H., Burkhardt, H., Caiazza, D., Calatroni, S., Campbell, M., Lasheras, N. Catalan, Cassany, B., Castro, E., Soares, R. H. Cavaleiro, Bastos, M. Cerqueira, Cherif, A., Chevallay, E., Cilento, V., Corsini, R., Costa, R., Cure, B., Curt, S., Gobbo, A. Dal, Dannheim, D., Daskalaki, E., Deacon, L., Degiovanni, A., De Michele, G., De Oliveira, L., Romano, V. Del Pozo, Delahaye, J. P., Delikaris, D., de Almeida, P. G. Dias, Dobers, T., Doebert, S., Doytchinov, I., Draper, M., Ramos, F. Duarte, Duquenne, M., Plaja, N. Egidos, Elsener, K., Esberg, J., Esposito, M., Evans, L., Fedosseev, V., Ferracin, P., Fiergolski, A., Foraz, K., Fowler, A., Friebel, F., Fuchs, J-F., Gaddi, A., Gamba, D., Fajardo, L. Garcia, Morales, H. Garcia, Garion, C., Gasior, M., Gatignon, L., Gayde, J-C., Gerbershagen, A., Gerwig, H., Giambelli, G., Gilardi, A., Goldblatt, A. N., Anton, S. Gonzalez, Grefe, C., Grudiev, A., Guerin, H., Guillot-Vignot, F. G., Gutt-Mostowy, M. L., Lutz, M. Hein, Hessler, C., Holma, J. K., Holzer, E. B., Hourican, M., Hynds, D., Ikarios, E., Levinsen, Y. Inntjore, Janssens, S., Jeff, A., Jensen, E., Jonker, M., Kamugasa, S. W., Kastriotou, M., Kemppinen, J. M. K., Khan, V., Kieffer, R. B., Klempt, W., Kokkinis, N., Kossyvakis, I., Kostka, Z., Korsback, A., Platia, E. Koukovini, Kovermann, J. W., Kozsar, C-I., Kremastiotis, I., Kröger, J., Kulis, S., Latina, A., Leaux, F., Lebrun, P., Lefevre, T., Leogrande, E., Linssen, L., Liu, X., Cudie, X. Llopart, Magnoni, S., Maidana, C., Maier, A. A., Durand, H. Mainaud, Mallows, S., Manosperti, E., Marelli, C., Lacoma, E. Marin, Marsh, S., Martin, R., Martini, I., Martyanov, M., Mazzoni, S., Mcmonagle, G., Mether, L. M., Meynier, C., Modena, M., Moilanen, A., Mondello, R., Cabral, P. B. Moniz, Irazabal, N. Mouriz, Munker, M., Muranaka, T., Nadenau, J., Navarro, J. G., Quirante, J. L. Navarro, Del Busto, E. Nebo, Nikiforou, N., Ninin, P., Nonis, M., Nisbet, D., Nuiry, F. X., Nürnberg, A., Ögren, J., Osborne, J., Ouniche, A. C., Pan, R., Papadopoulou, S., Papaphilippou, Y., Paraskaki, G., Pastushenko, A., Passarelli, A., Patecki, M., Pazdera, L., Pellegrini, D., Pepitone, K., Codina, E. Perez, Fontenla, A. Perez, Persson, T. H. B., Petrič, M., Pitman, S., Pitters, F., Pittet, S., Plassard, F., Popescu, D., Quast, T., Rajamak, R., Redford, S., Remandet, L., Renier, Y., Rey, S. F., Orozco, O. Rey, Riddone, G., Castro, E. Rodriguez, Roloff, P., Rossi, C., Rossi, F., Rude, V., Ruehl, I., Rumolo, G., Sailer, A., Sandomierski, J., Santin, E., Sanz, C., Bedolla, J. Sauza, Schnoor, U., Schmickler, H., Schulte, D., Senes, E., Serpico, C., Severino, G., Shipman, N., Sicking, E., Simoniello, R., Skowronski, P. K., Mompean, P. Sobrino, Soby, L., Sollander, P., Solodko, A., Sosin, M. P., Spannagel, S., Sroka, S., Stapnes, S., Sterbini, G., Stern, G., Ström, R., Stuart, M. J., Syratchev, I., Szypula, K., Tecker, F., Thonet, P. A., Thrane, P., Timeo, L., Tiirakari, M., Garcia, R. Tomas, Tomoiaga, C. I., Valerio, P., Vaňát, T., Vamvakas, A. L., Van Hoorne, J., Viazlo, O., Pinto, M. Vicente Barreto, Vitoratou, N., Vlachakis, V., Weber, M. A., Wegner, R., Wendt, M., Widorski, M., Williams, O. E., Williams, M., Woolley, B., Wuensch, W., Wulzer, A., Uythoven, J., Xydou, A., Yang, R., Zelios, A., Zhao, Y., Zisopoulos, P., Benoit, M., Sultan, D M S, Riva, F., Bopp, M., Braun, H. H., Craievich, P., Dehler, M., Garvey, T., Pedrozzi, M., Raguin, J. Y., Rivkin, L., Zennaro, R., Guillaume, S., Rothacher, M., Aksoy, A., Nergiz, Z., Yavas, Ö., Denizli, H., Keskin, U., Oyulmaz, K. Y., Senol, A., Ciftci, A. K., Baturin, V., Karpenko, O., Kholodov, R., Lebed, O., Lebedynskyi, S., Mordyk, S., Musienko, I., Profatilova, Ia., Storizhko, V., Bosley, R. R., Price, T., Watson, M. F., Watson, N. K., Winter, A. G., Goldstein, J., Green, S., Marshall, J. S., Thomson, M. A., Xu, B., You, T., Gillespie, W. A., Spannowsky, M., Beggan, C., Martin, V., Zhang, Y., Protopopescu, D., Robson, A., Apsimon, R. J., Bailey, I., Burt, G. C., Dexter, A. C., Edwards, A. V., Hill, V., Jamison, S., Millar, W. L., Papke, K., Casse, G., Vossebeld, J., Aumeyr, T., Bergamaschi, M., Bobb, L., Bosco, A., Boogert, S., Boorman, G., Cullinan, F., Gibson, S., Karataev, P., Kruchinin, K., Lekomtsev, K., Lyapin, A., Nevay, L., Shields, W., Snuverink, J., Towler, J., Yamakawa, E., Boisvert, V., West, S., Jones, R., Joshi, N., Bett, D., Bodenstein, R. M., Bromwich, T., Burrows, P. N., Christian, G. B., Gohil, C., Korysko, P., Paszkiewicz, J., Perry, C., Ramjiawan, R., Roberts, J., Coates, T., Salvatore, F., Bainbridge, A., Clarke, J. A., Krumpa, N., Shepherd, B. J. A., Walsh, D., Chekanov, S., Demarteau, M., Gai, W., Liu, W., Metcalfe, J., Power, J., Repond, J., Weerts, H., Xia, L., Zupan, J., Wells, J. D., Zhang, Z., Adolphsen, C., Barklow, T., Dolgashev, V., Franzi, M., Graf, N., Hewett, J., Kemp, M., Kononenko, O., Markiewicz, T., Moffeit, K., Neilson, J., Nosochkov, Y., Oriunno, M., Phinney, N., Rizzo, T., Tantawi, S., Wang, J., Weatherford, B., White, G., and Woodley, M.

Subjects
Physics - Accelerator Physics
Abstract

The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear $e^+e^-$ collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years., Comment: 112 pages, 59 figures; published as CERN Yellow Report Monograph Vol. 2/2018; corresponding editors: Philip N. Burrows, Nuria Catalan Lasheras, Lucie Linssen, Marko Petri\v{c}, Aidan Robson, Daniel Schulte, Eva Sicking, Steinar Stapnes

Published
2018
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8. 3D Geomodelling of Alpine structures with PZero

Author

Monti, R, Bistacchi, A, Benedetti, G, Hussain, W, Monti,R, Bistacchi,A, Benedetti,G, Hussain,W, Monti, R, Bistacchi, A, Benedetti, G, Hussain, W, Monti,R, Bistacchi,A, Benedetti,G, and Hussain,W

Abstract

Three-dimensional geological modelling is a rapidly growing field of interest and application, both in research and industry, leading to the emergence of open-source software to make this technology more accessible. Here we present PZero, an open-source software written in Python, created and developed by GECOS-LAB (github.com/gecos-lab) and now supported by the GeoSciences IR project (geosciences-ir.it). PZero is a 3D geological modelling software with a user-friendly Qt graphical interface designed for the structural geologist, allowing explicit and implicit interpolation (using LoopStructural) of geological structures from different input datasets, including field geological and structural surveys, Digital Outcrop Models, but also subsurface data such as wells and seismics. One important development branch of PZero is focused on modelling strategies and interpolation algorithms for 3D modelling of complex ductile structures, such as refolded isoclinal folds and shear zones. For this task we have selected a case study from the Penninic Domain of the Central Alps, characterized by continental and oceanic units that were deeply involved in subduction- and collision-related tectonics, then exhumed and crosscut by late-stage brittle faults, resulting in very challenging natural laboratory, where the latest modelling strategies can be tested in depth.

Published
2024

11. Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Author

Bachelot, T., Bouzid, K., Campone, M., Desmoulins, I., Coudert, B., Bondarenko, I., Nowecki, Z., Glogowska, I., Ciruelos Gil, E., Errihani, H., Dalenc, F., Ricci, F., Dieras, V., Kaufman, B., Paluch-Shimon, S., Wardley, A., Schneeweiss, A., Ferreira, A., Mano, M., Kalofonos, H., Andreetta, C., Puglisi, F., Montemurro, F., Barrett, S., Zhang, Q., Mavroudis, D., Matus, J., Villarreal Garza, C., Beato, C., Ismael, G., Hu, X., Abdel Azeem, H., Gaafar, R., Perrin, C., Kerbrat, P., Ettl, J., Paepke, S., Hitre, E., Lang, I., Trudeau, M., Verma, S., Li, H., Hoffmann, O., Aktas, B., Cariello, A., Cruciani, G., Tienghi, A., Tondini, C., Al-Twegieri, T., Loman, N., Laing, R., Miles, D., Brain, E., Fasching, P., Lux, M., Frassoldati, A., Aziz, Z., Salas, J., Streb, J., Krzemieniecki, K., Wronski, A., Garcia Garcia, J., Menjon Beltran, S., Cicin, I., Schmid, P., Gallagher, C., Turner, N., Tong, Z., Boer, K., Juhász, B., Horvath, Z., Bianchini, G., Gianni, L., Curigliano, G., Juarez Ramiro, A., Susnjar, S., Matos, E., Sevillano, E., Garcia Estevez, L., Gokmen, E., Uslu, R., Wildiers, H., Schutz, F., Cruz, M., Bourgeois, H., von Schumann, R., Stemmer, S., Dominguez, A., Morales-Vásques, F., Wojtukiewicz, M., Trifunovic, J., Echarri Gonzalez, M.J., Illarramendi Mañas, J., Martinez De Dueñas, E., Voitko, N., Hicks, J., Waters, S., Barrett-Lee, P., Wheatley, D., De Boer, R., Cocquyt, V., Jerusalem, G., Barrios, C., Panasci, L., Mattson, J., Tanner, M., Gozy, M., Vasilopoulos, G., Papandreou, C., Revesz, J., Battelli, N., Benedetti, G., Latini, L., Gridelli, C., Lazaro Leon, J., Alarcón Company, J., Arance Fernandez, A., Barnadas Molins, A., Calvo Plaza, I., Bratos, R., Gonzalez Martin, A., Izarzugaza Peron, Y., Klint, L., Kovalev, A., McCarthy, N., Yeo, B., Kee, D., Thomson, J., White, S., Greil, R., Wang, S., Artignan, X., Juhasz-Böess, I., Rody, A., Ngan, R., Dourleshter, F., Goldberg, H., Doni, L., Di Costanzo, F., Ferraù, F., Drobniene, M., Aleknavicius, E., Rashid, K., Costa, L., de la Cruz Merino, L., Garcia Saenz, J., López, R., Del Val Munoz, O., Ozyilkan, O., Azribi, F., Jaafar, H., Baird, R., Verrill, M., Beith, J., Petzer, A., Moreira de Andrade, J., Bernstein, V., Macpherson, N., Rayson, D., Saad Eldin, I., Achille, M., Augereau, P., Müller, V., Rasco, A., Evron, E., Katz, D., Berardi, R., Cascinu, S., De Censi, A., Gennari, A., El-Saghir, N., Ghosn, M., Oosterkamp, H.M., Van den Bosch, J., Kukulska, M., Kalinka, E., Alonso, J., Dalmau Portulas, E., Del Mar Gordon Santiago, M., Pelaez Fernandez, I., Aksoy, S., Altundag, K., Senol Coskun, H., Bozcuk, H., Shparyk, Y., Barraclough, L., Levitt, N., Panwar, U., Kelly, S., Rigg, A., Varughese, M., Castillo, C., Fein, L., Malik, L., Stuart-Harris, R., Singer, C., Stoeger, H., Samonigg, H., Feng, J., Cedeño, M., Ruohola, J., Berdah, J.-F., Goncalves, A., Orfeuvre, H., Grischke, E.-M., Simon, E., Wagner, S., Koumakis, G., Papazisis, K., Ben Baruch, N., Fried, G., Geffen, D., Karminsky, N., Peretz, T., Cavanna, L., Pedrazzioli, P., Grasso, D., Ruggeri, E., D’Auria, G., Moscetti, L., Juozaityte, E., Rodriguez Cid, J., Roerdink, H., Siddiqi, N., Passos Coelho, J., Arcediano Del Amo, A., Garcia Garre, E., García Gonzalez, M., Garcia-Palomo Perez, A., Herenandez Perez, C., Lopez Alvarez, P., Lopez De Ceballos, M.H., Martínez Jañez, N., Mele Olive, M., McAdam, K., Perren, T., Dunn, G., Humphreys, A., Taylor, W., Vera, R., Kaen, L., Andel, J., Steger, G., De Grève, J., Huizing, M., Hegg, R., Joy, A., Kuruvilla, P., Sehdev, S., Smiljanic, S., Kütner, R., Alexandre, J., Grosjean, J., Laplaige, P., Largillier, R., Maes, P., Martin, P., Pottier, V., Christensen, B., Khandan, F., Lück, H.-J., Zahm, D.-M., Fountzilas, G., Karavasilis, V., Safra, T., Inbar, M., Ryvo, L., Bonetti, A., Seles, E., Giacobino, A., Chavarri Guerra, Y., de Jongh, F., van der Velden, A., van Warmerdam, L., Vrijaldenhoven, S., Smorenburg, C.H., Cavero, M., Andres Conejero, R., Oltra Ferrando, A., Redondo Sanchez, A., Ribelles Entrena, N., Saura Grau, S., Viñas Vilaro, G., Bachmeier, K., Beresford, M., Butt, M., Joffe, J., Poole, C., Woodings, P., Chakraborti, P., Yordi, G., Woodward, N., Nobre, A., Luiz Amorim, G., Califaretti, N., Fox, S., Robidoux, A., Li, E., Li, N., Jiang, J., Soria, T., Padrik, P., Lahdenpera, O., Barletta, H., Dohollou, N., Genet, D., Prulhiere, K., Coeffic, D., Facchini, T., Vieillot, S., Catala, S., Teixeira, L., Hesse, T., Kühn, T., Ober, A., Repp, R., Schröder, W., Pectasides, D., Bodoky, G., Kahan, Z., Jiveliouk, I., Rosengarten, O., Rossi, V., Alabiso, O., Pérez Martínez, M., van de Wouw, A.J., Smok-Kalwat, J., Damasecno, M., Augusto, I., Sousa, G., Saadein, A., Abdelhafiez, N., Abulkhair, O., Antón Torres, A., Corbellas Aparicio, M., Llorente Domenech, R., Florián Jerico, J., Garcia Mata, J., Gil Raga, M., Galan Brotons, A., Llombart Cussac, A., Llorca Ferrandiz, C., Martinez Del Prado, P., Olier Garate, C., Rodriguez Sanchez, C., Sanchez Gomez, R., Santisteban Eslava, M., Soberino, J., Vidal Losada Garcia, M., Soto de Prado, D., Torrego Garcia, J., Vicente Rubio, E., Garcia, M., Murias Rosales, A., Granstam Björneklett, H., Narbe, U., Jafri, M., Rea, D., Newby, J., Jones, A., Westwell, S., Ring, A., Alonso, I., Rodríguez, R., Ciruelos, E., Peretz-Yablonski, T., Merot, J.-L., Trask, P., du Toit, Y., Pena-Murillo, C., Revelant, V., and Klingbiel, D.

Published
2021
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12. Hydrogeological parameterisation of the Daruvar thermal aquifer: integration of fracture network analysis and well testing

Author

Kosović, I, Null, N, Matoš, B, Casiraghi, S, Benedetti, G, Frangen, T, Urumović, K, Pavičić, I, Bistacchi, A, Mittempergher, S, Pola, M, Borović, S, Kosović, Ivan, null, null, Matoš, Bojan, Casiraghi, Stefano, Benedetti, Gabriele, Frangen, Tihomir, Urumović, Kosta, Pavičić, Ivica, Bistacchi, Andrea, Mittempergher, Silvia, Pola, Marco, Borović, Staša, Kosović, I, Null, N, Matoš, B, Casiraghi, S, Benedetti, G, Frangen, T, Urumović, K, Pavičić, I, Bistacchi, A, Mittempergher, S, Pola, M, Borović, S, Kosović, Ivan, null, null, Matoš, Bojan, Casiraghi, Stefano, Benedetti, Gabriele, Frangen, Tihomir, Urumović, Kosta, Pavičić, Ivica, Bistacchi, Andrea, Mittempergher, Silvia, Pola, Marco, and Borović, Staša

Abstract

Highly fractured Mesozoic carbonate rocks are the main reservoir of many geothermal resources in northern Croatia, being of environmental, cultural, and economic value for the local and regional communities. The Daruvar thermal springs (temperatures < 50°C) represent the outflow area of an intermediate scale, tectonically controlled, hydrothermal system hosted in Triassic carbonate rocks. Several investigations have been conducted in the Daruvar area detailing the architecture of regional and local fracture networks and quantifying the hydrogeological parameters of the thermal aquifer. In this work, an integrated approach based on structural and hydrogeological investigations was employed to model the network of fractures in the reservoir and quantify its impact on the hydraulic properties. Structural investigations were conducted in the Batinjska Rijeka quarry, considered as an outcrop analogue of the thermal aquifer, employing both a classical field approach and the virtual quantitative analysis of a 3D digital outcrop model. Structural analysis of the digital outcrop model allowed identification of two sub-vertical systems of discontinuities, dipping to the NW and the WSW respectively, in accordance with the data collected through direct field measurements. The main geometric features of the discontinuity network and their statistical distributions were employed to construct discrete fracture network models at both the outcrop scale (approximately 100 m) and the aquifer scale in Daruvar (approximately 700 m). Calibration of the input parameters allowed modelling of porosity and permeability values that reproduce the field values assessed through pumping tests, well tests, and well logging. This work highlights the importance of integrating geological and hydrogeological investigations to obtain a more reliable reconstruction and quantification of the processes driving the fluid flow in fractured aquifers and affecting the spatial distribution of their hydrauli

Published
2024

19. Clinical Sports Medicine

Author

Hettchen M, von Stengel S, Kohl M, Murphy MH, Shojaa M, Ghasemikaram M, Bragonzoni L, Benvenuti F, Ripamonti C, Benedetti G, Julin M, Risto T, and Kemmler W

Subjects
Sports medicine, RC1200-1245
Abstract

Purpose: The menopausal transition is a critical period in womens lives. The central aim of the present study was to evaluate the effect of a multimodal exercise protocol on the cardiometabolic risk factor potentially related to menopausal transition in early postmenopausal women. Methods: Fifty-four (54) early-postmenopausal women (54.01.8 years) were randomly assigned to two groups: (1) exercise group (EG: n=27) which conducted a high intensity aerobic and resistance training three times/week and (2) active control group (CG: n=27) exercising once a week with low exercise intensity. Besides bone density, the main variable of this project, the outcome variable in this thesis was also cardiometabolic risk, as summarized by the Metabolic Syndrome (MetS) Z-Score. We applied Intention-to-Treat (ITT) and Per Protocol Analyses (PPA) with multiple imputation and used standardized mean differences to illustrate the effects.Results: After 16 weeks of exercise two participants (EG: n=1; CG: n=1) were lost to follow-up. Effects for the MetS Z-Score were moderate (EG: -0.361.36 vs. CG: 0.512.28; SMD: 0.47, 95% CI: -0.08 to 1.03), albeit borderline non-significant (ITT: p=.089; PPA: p=.060). Conclusion: The present multimodal exercise protocol just failed to affect the MetS Z-Score and its underlying cardiometabolic risk factors. Whether this result can be generalized to the entire cohort of early-postmenopausal women or whether it has to be attributed to the only moderately high exercise intensity during the early weeks of the intervention along with a relatively short intervention period remains to be evaluated.Key Words: Metabolic Syndrome, MetS Z-Score, Menopausal Transition

Published
2021
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20. Design considerations for future DAFNE upgrade

Author

Alesini, D., Benedetti, G., Biagini, M. E., Biscari, C., Boni, R., Boscolo, M., Clozza, A., Monache, G. Delle, Di Pirro, G., Drago, A., Gallo, A., Ghigo, A., Guiducci, S., Incurvati, M., Levichev, E., Ligi, C., Marcellini, F., Mazzitelli, G., Milardi, C., Pellegrino, L., Preger, M. A., Raimondi, P., Ricci, R., Rotundo, U., Sanelli, C., Serio, M., Sgamma, F., Spataro, B., Piminov, P., Stecchi, A., Stella, A., Tazzioli, F., Vaccarezza, C., Vescovi, M., and Zobov, M.

Subjects
Physics - Accelerator Physics
Abstract

The Frascati F-Factory DAFNE has been delivering luminosity to the KLOE, DEAR and FINUDA experiments since year 2000. Since April 2004 the KLOE run has been resumed and recently peak luminosity of 1.0x1032 cm-2s-1 and integrated luminosity of 6.2 pb-1/day have been achieved. The scientific program of the three high-energy experiments sharing DAFNE operation will be completed approximately by the end of year 2006. A scientific program for DAFNE beyond that date has not been defined yet and it is matter of discussion in the high-energy physics and accelerator physics communities. In this paper we present some future scenarios for DAFNE, discussing the expected ultimate performances of the machine as it is now and addressing the design for an energy and/or luminosity upgrade. The options presented in the following are not exhaustive and they are intended to give a glance of what is doable using the existing infrastructures., Comment: Presented at the Workshop "DAFNE 2004: Physics at meson factories", 7-14 June 2004, LNF INFN, Frascati, Italy

Published
2004

21. DAFNE operation with the FINUDA experiment

Author

Milardi, C., Alesini, D., Benedetti, G., Biagini, M. E., Biscari, C., Boni, R., Boscolo, M., Clozza, A., Monache, D. Delle, Di Pirro, G., Drago, A., Gallo, A., Ghigo, A., Guiducci, S., Incurvati, M., Ligi, C., Marcellini, F., Mazzitelli, G., Pellegrino, L., Preger, M. A., Raimondi, P., Ricci, R., Rotundo, U., Sanelli, C., Serio, M., Sgamma, F., Spataro, B., Stecchi, A., Stella, A., Vaccarezza, C., Vescovi, M., and Zobov, M.

Subjects
Physics - Accelerator Physics
Abstract

DAFNE operation restarted in September 2003, after a six month shut-down for the installation of FINUDA, a magnetic detector dedicated to the study of hypernuclear physics. FINUDA is the third experiment running on DAFNE and operates while keeping on place the other detector KLOE. During the shut-down both Interaction Regions have been equipped with remotely controlled quadrupoles in order to operate at different solenoid fields. Among many other hardware upgrades one of the most significant is the reshaping of the wiggler pole profile to improve the field quality and the machine dynamic aperture. Commissioning of the collider in the new configuration has been completed in short time. The peak luminosity delivered to FINUDA has reached 6 10^31 s-1cm-2, with a daily integrated value close to 4 pb-1., Comment: 3 pages, 4 figures

Published
2004

22. DAFNE

Author

Guiducci, S., Alesini, D., Benedetti, G., Biagini, M. E., Biscari, C., Boni, R., Boscolo, M., Clozza, A., Monache, G. Delle, Di Pirro, G., Drago, A., Gallo, A., Ghigo, A., Marcellini, F., Mazzitelli, G., Milardi, C., Pellegrino, L., Preger, M. A., Raimondi, P., Ricci, R., Sanelli, C., Serio, M., Sgamma, F., Stecchi, A., Vaccarezza, C., and Zobov, M.

Subjects
Physics - Accelerator Physics
Abstract

The results of 2002 DAFNE operation for the two experiments KLOE and DEAR are described. During 2003 a long shutdown has been dedicated to the installation of new Interaction Regions (IR) and to hardware modifications and upgrades. In the last section optics studies and performances expectations for the new machine configuration are reported., Comment: Invited talk at the Workshop on e+e- in the 1-2 GeV range, Alghero, Italy, September 2003 (eConf C0309101)

Published
2004

23. DAFNE2: Lattice for a 2 GeV Electron Collider

Author

Benedetti, G.

Subjects
Physics - Accelerator Physics
Abstract

Within the general frame of the upgrade of the collider DAFNE to the neutron-antineutron energy threshold (2-2.5 GeV c.m.), modifications and different options for the accelerator design are discussed and a possible lattice for the Main Rings at 1 GeV is presented. The luminosity required by the experiments for such a light quark factory is of the order of few 10^31 cm-2 s-1, easily achievable in the particle factory era., Comment: Invited talk at the "Workshop on e+e- in the 1-2 GeV range", Alghero, Italy, September 2003 (eConf C0309101)

Published
2004

25. Estimation procedure of stumpage value: characteristics, contents and self-validation

Author

Benedetti G and Carbone F

Subjects
Generi di perizia, Criterio di stima, Procedimento di stima, Validazione, Analisi del processo estimativo, Analisi della capacità comunicativa, Forestry, SD1-669.5
Abstract

La perizia di stima da sempre ha quale obiettivo prioritario quello di informare il committente del valore di un bene. Rispetto al passato, questo elaborato oggi deve conformarsi agli standard della due diligence. In particolare, è richiesto che esso fornisca informazioni aggiuntive circa i caratteri del bene in stima e degli altri aspetti ad esso correlati. Inoltre, l’estensore è sollecitato ad avere la consapevolezza che la perizia deve comunicare a terzi, che non hanno competenze specifiche, aspetti sostanziali e tecnici. Il presente studio è stato sviluppato in riferimento alla perizia di determinazione del valore del soprassuolo da abbattere. Dopo aver brevemente introdotto gli aspetti teorici di base, è stato effettuata l’analisi di un campione di 22 perizie. Tre sono gli aspetti principali sotto esame: gli aspetti formali, il processo estimativo e la capacità di comunicazione dell’elaborato. Dall’analisi sono emersi molti aspetti critici, alcuni dei quali possono essere spiegati dall’istituzionalizzazione del processo del valore di macchiatico da parte del Corpo Forestale dello Stato, oggi non più operativo. Nelle conclusioni si evidenziano i punti critici delle perizie esaminate e vengono proposti alcuni suggerimenti per l’estimatore forestale al fine di produrre un report coerente con gli standard propri della due diligence. Inoltre, si propone l’uso delle matrici utilizzate nel presente studio come strumenti per la validazione di parte seconda della perizia.

Published
2018
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26. Anal trauma caused by bull-horn injury.

Author

Jara Benedetti, G., Maiocchi Segredo, K., Martínez Hernández, A., and Pastor Mora, J.

Subjects
*COLOSTOMY, *ANUS, *WOUNDS & injuries, *SURGICAL wound dehiscence
Abstract

Background: Bullfighting festivals are commonly performed at Spain. Perineal trauma due to bull-horn injury is associated with high morbidity due to sphincteric associated lesions Methods: We report a case of 37-year-old male patient with anal trauma due to a bull-horn injury involving the sphincter complex, treated in our Emergency department Results: Urgent surgery was performed with primary sphincteroplasty, without performing a colostomy. The associated complication was a partial dehiscence of the surgical wound (Clavien-Dindo I). No transfusions, re-interventions or readmissions were registered. The degree of incontinence at discharge and after 12 month follow-up, according to the Wexner scale was 8 points and 2 points, respectively. Conclusions: The main treatment of bull-horn injuries is extensive surgical debridement, antibiotic therapy, and lavage of the area. In cases involving the anal sphincter, primary sphincteroplasty is recommended. The modern trend does not include the systematic performance of a colostomy however, it has been described in cases with catastrophic wounds and urological lesions associated. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Validation of Esaso Classification of Diabetic Maculopathy

Author

Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., Scupola A., Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., and Scupola A.

Abstract

Purpose: To test reliability and reproducibility of ESASO morphologic OCT-based classification of diabetic maculopathy (DM). Methods: This is a multi-center cross-sectional study including a coordination center (CC) and 18 participating centers (PCs). After instruction on the correct use of ESASO Classification, the validation process was carried out in two consecutive stages. In the first retrospective phase, we evaluated the concordance between PCs and CC in the staging of OCT images collected during PCs’ daily activity (608 images). In a second prospective phase, we analyzed the inter-observer agreement of staging assigned by each PCs to OCT images selected by the CC (22 images). Results: The overall concordance achieved in the retrospective phase was 89.8% (Kappa = 0.83 (95% CI: 0.78–0.87); p<0.0001). In 99.5% of cases, concordance did not differ by more than one stage. In the prospective phase, PCs reached an inter-operator agreement of 93.0% (Krippendorff's Alpha = 0.953, 95% CI: 0.929–0.977, p<0.0001). Any discrepancy among the 22 images was within one stage. Conclusion: The results achieved in this study confirm that ESASO OCT-based Classification can be considered as an easy and reproducible method to stage DM during clinical practice. A diffused use of a common and validated method to describe the progression of retinal damage in DM may offer several clinical and scientific advantages.

Published
2023

37. Age matters: differences in exercise-induced cardiovascular remodelling in young and middle aged healthy sedentary individuals

Author

Torlasco, C, D'Silva, A, Bhuva, A, Faini, A, Augusto, J, Knott, K, Benedetti, G, Jones, S, Zalen, J, Scully, P, Lobascio, I, Parati, G, Lloyd, G, Hughes, A, Manisty, C, Sharma, S, Moon, J, Torlasco C., D'Silva A., Bhuva A. N., Faini A., Augusto J. B., Knott K. D., Benedetti G., Jones S., Zalen J. V., Scully P., Lobascio I., Parati G., Lloyd G., Hughes A. D., Manisty C. H., Sharma S., Moon J. C., Torlasco, C, D'Silva, A, Bhuva, A, Faini, A, Augusto, J, Knott, K, Benedetti, G, Jones, S, Zalen, J, Scully, P, Lobascio, I, Parati, G, Lloyd, G, Hughes, A, Manisty, C, Sharma, S, Moon, J, Torlasco C., D'Silva A., Bhuva A. N., Faini A., Augusto J. B., Knott K. D., Benedetti G., Jones S., Zalen J. V., Scully P., Lobascio I., Parati G., Lloyd G., Hughes A. D., Manisty C. H., Sharma S., and Moon J. C.

Abstract

Aims: Remodelling of the cardiovascular system (including heart and vasculature) is a dynamic process influenced by multiple physiological and pathological factors. We sought to understand whether remodelling in response to a stimulus, exercise training, altered with healthy ageing. Methods: A total of 237 untrained healthy male and female subjects volunteering for their first time marathon were recruited. At baseline and after 6 months of unsupervised training, race completers underwent tests including 1.5T cardiac magnetic resonance, brachial and non-invasive central blood pressure assessment. For analysis, runners were divided by age into under or over 35 years (U35, O35). Results: Injury and completion rates were similar among the groups; 138 runners (U35: n = 71, women 49%; O35: n = 67, women 51%) completed the race. On average, U35 were faster by 37 minutes (12%). Training induced a small increase in left ventricular mass in both groups (3 g/m2, P < 0.001), but U35 also increased ventricular cavity sizes (left ventricular end-diastolic volume (EDV)i +3%; left ventricular end-systolic volume (ESV)i +8%; right ventricular end-diastolic volume (EDV)i +4%; right ventricular end-systolic volume (ESV)i +5%; P < 0.01 for all). Systemic aortic compliance fell in the whole sample by 7% (P = 0.020) and, especially in O35, also systemic vascular resistance (–4% in the whole sample, P = 0.04) and blood pressure (systolic/diastolic, whole sample: brachial –4/–3 mmHg, central –4/–2 mmHg, all P < 0.001; O35: brachial –6/–3 mmHg, central –6/–4 mmHg, all P < 0.001). Conclusion: Medium-term, unsupervised physical training in healthy sedentary individuals induces measurable remodelling of both heart and vasculature. This amount is age dependent, with predominant cardiac remodelling when younger and predominantly vascular remodelling when older.

Published
2021

38. T 1 mapping performance and measurement repeatability: Results from the multi-national T 1 mapping standardization phantom program (T1MES)

Author

Captur, G, Bhandari, A, Bruhl, R, Ittermann, B, Keenan, K, Yang, Y, Eames, R, Benedetti, G, Torlasco, C, Ricketts, L, Boubertakh, R, Fatih, N, Greenwood, J, Paulis, L, Lawton, C, Bucciarelli-Ducci, C, Lamb, H, Steeds, R, Leung, S, Berry, C, Valentin, S, Flett, A, De Lange, C, Decobelli, F, Viallon, M, Croisille, P, Higgins, D, Greiser, A, Pang, W, Hamilton-Craig, C, Strugnell, W, Dresselaers, T, Barison, A, Dawson, D, Taylor, A, Mongeon, F, Plein, S, Messroghli, D, Al-Mallah, M, Grieve, S, Lombardi, M, Jang, J, Salerno, M, Chaturvedi, N, Kellman, P, Bluemke, D, Nezafat, R, Gatehouse, P, Moon, J, Captur G., Bhandari A., Bruhl R., Ittermann B., Keenan K. E., Yang Y., Eames R. J., Benedetti G., Torlasco C., Ricketts L., Boubertakh R., Fatih N., Greenwood J. P., Paulis L. E. M., Lawton C. B., Bucciarelli-Ducci C., Lamb H. J., Steeds R., Leung S. W., Berry C., Valentin S., Flett A., De Lange C., Decobelli F., Viallon M., Croisille P., Higgins D. M., Greiser A., Pang W., Hamilton-Craig C., Strugnell W. E., Dresselaers T., Barison A., Dawson D., Taylor A. J., Mongeon F. -P., Plein S., Messroghli D., Al-Mallah M., Grieve S. M., Lombardi M., Jang J., Salerno M., Chaturvedi N., Kellman P., Bluemke D. A., Nezafat R., Gatehouse P., Moon J. C., Captur, G, Bhandari, A, Bruhl, R, Ittermann, B, Keenan, K, Yang, Y, Eames, R, Benedetti, G, Torlasco, C, Ricketts, L, Boubertakh, R, Fatih, N, Greenwood, J, Paulis, L, Lawton, C, Bucciarelli-Ducci, C, Lamb, H, Steeds, R, Leung, S, Berry, C, Valentin, S, Flett, A, De Lange, C, Decobelli, F, Viallon, M, Croisille, P, Higgins, D, Greiser, A, Pang, W, Hamilton-Craig, C, Strugnell, W, Dresselaers, T, Barison, A, Dawson, D, Taylor, A, Mongeon, F, Plein, S, Messroghli, D, Al-Mallah, M, Grieve, S, Lombardi, M, Jang, J, Salerno, M, Chaturvedi, N, Kellman, P, Bluemke, D, Nezafat, R, Gatehouse, P, Moon, J, Captur G., Bhandari A., Bruhl R., Ittermann B., Keenan K. E., Yang Y., Eames R. J., Benedetti G., Torlasco C., Ricketts L., Boubertakh R., Fatih N., Greenwood J. P., Paulis L. E. M., Lawton C. B., Bucciarelli-Ducci C., Lamb H. J., Steeds R., Leung S. W., Berry C., Valentin S., Flett A., De Lange C., Decobelli F., Viallon M., Croisille P., Higgins D. M., Greiser A., Pang W., Hamilton-Craig C., Strugnell W. E., Dresselaers T., Barison A., Dawson D., Taylor A. J., Mongeon F. -P., Plein S., Messroghli D., Al-Mallah M., Grieve S. M., Lombardi M., Jang J., Salerno M., Chaturvedi N., Kellman P., Bluemke D. A., Nezafat R., Gatehouse P., and Moon J. C.

Abstract

Background: The T 1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T 1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T 1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods: Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B 0 and B 1, and "reference" slow T 1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T 1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5 T and 22 3 T magnets using multiple T 1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T 1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T 1 variation. Results: Over 2 years, phantom gel integrity remained intact (no rips/tears), B 0 and B 1 homogenous, and "reference" T 1 stable compared to baseline (% change at 1.5 T, 1.95 ± 1.39%; 3 T, 2.22 ± 1.44%). Per degrees Celsius, 1.5 T, T 1 (MOLLI 5s(3s)3s) increased by 11.4 ms in long native blood tubes and decreased by 1.2 ms in short post-contrast myocardium tubes. Agreement of estimated T 1 times with "reference" T 1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R 2 ranges for both field strengths, 0.99-1.00). Over 1 year, many 1.5 T and 3 T sequences/magnets were repeatable with mean CoVs < 1 and 2% respectively. Repeatability was narrower for 1.5 T over 3 T. Within T1MES repeatability for native T 1 was narrow for several sequences, for example, at 1.5 T, Siemens MOLLI 5s(3s)3s prototype number 448B (

Published
2020

49. Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Author

Miles, D., primary, Ciruelos, E., additional, Schneeweiss, A., additional, Puglisi, F., additional, Peretz-Yablonski, T., additional, Campone, M., additional, Bondarenko, I., additional, Nowecki, Z., additional, Errihani, H., additional, Paluch-Shimon, S., additional, Wardley, A., additional, Merot, J.-L., additional, Trask, P., additional, du Toit, Y., additional, Pena-Murillo, C., additional, Revelant, V., additional, Klingbiel, D., additional, Bachelot, T., additional, Bouzid, K., additional, Desmoulins, I., additional, Coudert, B., additional, Glogowska, I., additional, Ciruelos Gil, E., additional, Dalenc, F., additional, Ricci, F., additional, Dieras, V., additional, Kaufman, B., additional, Ferreira, A., additional, Mano, M., additional, Kalofonos, H., additional, Andreetta, C., additional, Montemurro, F., additional, Barrett, S., additional, Zhang, Q., additional, Mavroudis, D., additional, Matus, J., additional, Villarreal Garza, C., additional, Beato, C., additional, Ismael, G., additional, Hu, X., additional, Abdel Azeem, H., additional, Gaafar, R., additional, Perrin, C., additional, Kerbrat, P., additional, Ettl, J., additional, Paepke, S., additional, Hitre, E., additional, Lang, I., additional, Trudeau, M., additional, Verma, S., additional, Li, H., additional, Hoffmann, O., additional, Aktas, B., additional, Cariello, A., additional, Cruciani, G., additional, Tienghi, A., additional, Tondini, C., additional, Al-Twegieri, T., additional, Loman, N., additional, Laing, R., additional, Miles, D., additional, Brain, E., additional, Fasching, P., additional, Lux, M., additional, Frassoldati, A., additional, Aziz, Z., additional, Salas, J., additional, Streb, J., additional, Krzemieniecki, K., additional, Wronski, A., additional, Garcia Garcia, J., additional, Menjon Beltran, S., additional, Cicin, I., additional, Schmid, P., additional, Gallagher, C., additional, Turner, N., additional, Tong, Z., additional, Boer, K., additional, Juhász, B., additional, Horvath, Z., additional, Bianchini, G., additional, Gianni, L., additional, Curigliano, G., additional, Juarez Ramiro, A., additional, Susnjar, S., additional, Matos, E., additional, Sevillano, E., additional, Garcia Estevez, L., additional, Gokmen, E., additional, Uslu, R., additional, Wildiers, H., additional, Schutz, F., additional, Cruz, M., additional, Bourgeois, H., additional, von Schumann, R., additional, Stemmer, S., additional, Dominguez, A., additional, Morales-Vásques, F., additional, Wojtukiewicz, M., additional, Trifunovic, J., additional, Echarri Gonzalez, M.J., additional, Illarramendi Mañas, J., additional, Martinez De Dueñas, E., additional, Voitko, N., additional, Hicks, J., additional, Waters, S., additional, Barrett-Lee, P., additional, Wheatley, D., additional, De Boer, R., additional, Cocquyt, V., additional, Jerusalem, G., additional, Barrios, C., additional, Panasci, L., additional, Mattson, J., additional, Tanner, M., additional, Gozy, M., additional, 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Published
2021
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50. Monitoring healthcare-associated infections and antimicrobial use at regional level through repeated point prevalence surveys: what can be learnt?

Author

Arnoldo, L, Smaniotto, C, Celotto, D, Brunelli, L, Cocconi, R, Tignonsini, D, Faruzzo, A, Brusaferro, S, Collazzo, R, Mansutti, M, Martellotta, F, Giacomini, M, Del Ben, G, Vigo, C, Marino, M, Farneti, F, Franca, G, Calligaris, L, Giuliani, C, Perossa, R, Carlovich, C, Valentinis, A, Compassi, S, Guarneri, S, Rasman, W, Kette, F, Toscani, P, Crapis, M, Santarossa, A, Bigaran, A, Maggiore, A, Croci, E, Germanis, L, Perulli, A, Monteverdi, D, Zobec, S, Benedetti, G, Montesi, Mc, Petronio, L, Sfreddo, P, Giurco, C, Rieppi, C, Alessandrini, V, Zuliani, P, Polonia, M, Pipan, C, and the FVG Regional 'safety Care' Group

Subjects
Adult, Male, Microbiology (medical), Healthcare associated infections, Infection prevention and control, animal structures, Adolescent, Prevalence, 030501 epidemiology, Young Adult, 03 medical and health sciences, Environmental health, Humans, Medicine, Infection control, Healthcare-associated infection, Child, Aged, Aged, 80 and over, Repeated prevalence, Cross Infection, Infection Control, 0303 health sciences, 030306 microbiology, business.industry, Infant, Newborn, Infant, virus diseases, General Medicine, Middle Aged, Drug Utilization, Hospitals, Anti-Bacterial Agents, Friuli venezia giulia, Antimicrobial use, Infectious Diseases, Italy, Child, Preschool, Female, Disease prevention, Health Services Research, 0305 other medical science, business
Abstract

Healthcare-associated infections (HAIs) surveillance is an essential part of any infection prevention and control programme. Repeated point prevalence surveys (PPSs) according to European Centre for Disease Prevention and Control (ECDC) protocol have been implemented in all Friuli Venezia Giulia (FVG) region (Italy) acute hospitals to reduce and control HAIs.Using the repeated PPSs within a regional-healthcare system (RHS) to promote and evaluate infection prevention and control (IPC) programmes.The standard versions of the ECDC PPS protocols were used in all four surveys (2011, 2013, 2015, 2017). All RHS public and private accredited hospitals were involved within the 'safe care network' programme.The numbers of surveyed patients in the four PPSs were 3172, 3253, 2969 and 3036, respectively. Prevalence of HAIs and antimicrobial use (AU) decreased significantly from 2011: HAIs (P0.05) 7.1%, 6.3%, 5.5%, 5.8% and AU (P0.01) 40.4%, 39.2%, 36.0%, 37.2%, respectively. The appropriateness of duration of surgical prophylaxis increased significantly (24 h increased through surveys related to one in 2011: odds ratio (OR), 95% confidence interval (CI) 1.29, 0.92-1.81; 1.95, 1.31-2.91; 1.78, 1.20-2.64, respectively). The most frequently detected HAIs were: bloodstream, urinary tract, pneumonia and surgical site (more than the 70% of HAIs in each PPS).The FVG regional approach to HAIs and AU surveillance was able to contribute to reduce prevalence over a 7-year period. Furthermore, it was able to keep hospital attention on HAIs and AU through the years and to guarantee a standardized and comparable evaluation of HAIs and AU burden in all RHS hospitals, as well as impacting on HAIs and AU regional programmes.

Published
2019

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