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We present a preliminary study to introduce narratives as a first-class functionality in digital libraries. The general idea is to enrich those libraries with semantic networks of events providing a meaningful contextualisation of the digital libraries’ objects. More specific motivations are presented through a set of use cases by different actors who would benefit from using narratives for different purposes. Then, we consider a specific digital library, Europeana, the largest European digital library in the cultural heritage domain. We discuss how the Europeana Data Model could be extended for representing narratives, and we introduce an ontology for narratives. We also present a semi-automatic tool, which, on the basis of the ontology, supports the creation and visualisation of narratives, and we show how the tool has been employed to create a narrative of the life of the painter Gustav Klimt as a case study. In particular, we focus our attention on the functionality of the tool that allows extracting and proposing to the user specific digital objects for each event of the narrative.

Copyright of Journal of Constitutional History / Giornale di Storia Costituzionale is the property of Giornale di Storia Costituzionale (Journal of Constitutional History) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Scienza & Politica is the property of University of Bologna, Department of Political & Social Sciences Alma Mater Studiorum and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

HT

The role played by certain environmental factors in the improvement of wine quality has been well studied and proven in many researches. These permitted to become aware of the existence of a terroir factor which represents all the natural features (in terms of soil, climate and terrain) and human practices which together make wine production of a certain area unique, in terms of production method and wine properties. In this research, a soil modelling approach was used to assess how terroir altered in the past and how it will change in the next decades, and the influence of its evolution on wine quality.After the identification of the components making up the terroir in the research area (Vino Nobile di Montepulciano D.O.C.G. district, south-east Tuscany, Italy), the relations between terroir and viticultural parameters have been investigated from the statistical point of view, in order to find regression models which can be used to predict grape (and then wine) peculiarities, starting from the soil and other environmental features. The evolution through time of the environmental factors which were recognized to play a role in building the wine quality was then studied using the SoilGen model, both in the past and in the future (from 970 BC to 2099 AD), under different scenarios of climate change (RCP 4.5 and RCP 8.5) and soil management strategies (Organic-conservative, Organic with cover crops used as green manure, Tillage without cover crops and removing pruning residues).The model output served as a base to predict viticultural parameters using the same regression identified in the beginning of the research, under climate change and different agricultural practices. The results revealed an important change in grape properties over the last 500 years, due to a variation in the (micro-)climate of the area rather than land management by vignerons. When the effect of a drastic climate change in the upcoming 80 years was simulated, it was shown a severe quality decrease of those grape properties (playing a role in building wine peculiarities) which were predicted starting from variations in soil and climate. Nevertheless, some soil management practices seem to offset the decrease in terroir by mitigating the negative modifications in terroir caused by climate change.This new kind of approach permitted to get knowledge of how grapevine properties will evolve according to the change in its terroir settings, and this may lead to the adoption of appropriate vineyard management strategies in order to mitigate the climate change and to preserve the uniqueness of Vino Nobile di Montepulciano DOCG. [ABSTRACT FROM AUTHOR]

Antigen-binding Fc (Fcab™) fragments, where a novel antigen binding site is introduced by the mutagenesis of the C-terminal loops of the C H 3 domain, function as parts of bispecific IgG-like symmetrical antibodies when they replace their wild-type Fc. Their homodimeric structure typically leads to bivalent antigen binding. In particular, biological situations monovalent engagement, however, would be preferred, either for avoiding agonistic effects leading to safety issues, or the attractive option of combining a single chain (i.e., one half) of an Fcab fragment reactive with different antigens in one antibody. We present the strategies for construction and selection of yeast libraries displaying heterodimeric Fcab fragments and discuss the effects of altered thermostability of the basic Fc scaffold and novel library designs that lead to isolation of highly affine antigen binding clones., (© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)