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2. Sex differences in incidence of self-reported adverse drug reactions after percutaneous coronary intervention

Author

Pettersen, T, primary, Schjott, J, additional, Allore, H, additional, Bendz, B, additional, Borregaard, B, additional, Fridlund, B, additional, Hadjistavropoulos, H D, additional, Larsen, A I, additional, Nordrehaug, J E, additional, Rasmussen, T B, additional, Rotevatn, S, additional, Valaker, I, additional, Wentzel-Larsen, T, additional, and Norekval, T M, additional

Published
2023
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3. Sex differences in incidence of self-reported adverse drug reactions after percutaneous coronary intervention

Author

Pettersen, T., Schjott, J., Allore, H., Bendz, B., Borregaard, B., Fridlund, Bengt, Hadjistavropoulos, H.D., Larsen, A.I., Nordrehaug, J.E., Rasmussen, T.B., Rotevatn, S., Valaker, I., Wentzel-Larsen, T., Norekval, T.M., Pettersen, T., Schjott, J., Allore, H., Bendz, B., Borregaard, B., Fridlund, Bengt, Hadjistavropoulos, H.D., Larsen, A.I., Nordrehaug, J.E., Rasmussen, T.B., Rotevatn, S., Valaker, I., Wentzel-Larsen, T., and Norekval, T.M.

Abstract

Background Despite experiencing adverse drug reactions (ADRs) more often than men, the proportion of women participating in clinical drug trials is low. Thus, evidence for sex differences in the incidence of ADRs is limited. Aim To determine sex differences in incidence of self-reported ADRs after percutaneous coronary intervention (PCI). Further, to determine whether receiving information about ADRs is associated with sex. Methods CONCARDPCI is a prospective multicentre cohort study (N=3417) conducted at seven referral PCI centres in two Nordic countries. Clinical data were collected from patients’ medical records. Socio-demographic characteristics were obtained by self-report after PCI. Two questions from the Heart Continuity of Care Questionnaire (HCCQ) were used to determine if information about potential ADRs was received before hospital discharge. De novo created questions were used to determine if patients reported ADRs from prescribed therapy. Questionnaires were distributed two- (T1), six- (T2), and twelve months (T3) after hospital discharge to assess the incidence of self-reported ADRs in a longitudinal perspective. Logistic regression was utilised to scrutinize the aims, reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results Patients were predominantly male (78%), with a mean age of 65 years (SD 11). Female patients were older (68, SD 10). Acute coronary syndrome was the most frequent cause of admission for PCI (62%). At T1, 2656 of the included patients responded to the questions from the HCCQ. Of these, 1019 patients (39%) reported being informed of potential ADRs from prescribed therapy, 1075 patients (42%) reported not having been informed, 511 patients (20%) reported ‘Hard to decide’, and 51 (2%) reported ‘Not applicable’. Patients reporting ‘Hard to decide’ or ‘Not applicable’ were excluded from further analysis. Women were less likely to receive information than men (OR 0.58, CI 0.45 – 0.75, p<0.001). For the total study pop

Published
2023
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4. Informing patients about potential adverse drug reactions after percutaneous coronary intervention reduces the occurrence of self-reported adverse drug reactions

Author

Pettersen, T, primary, Schjott, J, additional, Allore, H, additional, Bendz, B, additional, Borregaard, B, additional, Fridlund, B, additional, Hadjistavropoulos, H D, additional, Larsen, A I, additional, Nordrehaug, J E, additional, Rasmussen, T B, additional, Rotevatn, S, additional, Valaker, I, additional, Wentzel-Larsen, T, additional, and Norekval, T M, additional

Published
2022
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6. Fibrinolytic markers in coronary thrombi

Author

Nordeng, J., primary, Helseth, R., additional, Åkra, S., additional, Hoffman, P., additional, Schandiz, H., additional, Roald, B., additional, Bendz, B., additional, Arnesen, H., additional, Solheim, S., additional, and Seljeflot, I., additional

Published
2022
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7. Perceptions of efficacy and safety of generic medicines in patients after percutaneous coronary intervention

Author

Pettersen, T., Schjott, J., Allore, H., Bendz, B., Borregaard, B., Fridlund, B., Larsen, A. I., Nordrehaug, J. E., Rotevatn, S., Wentzel-Larsen, T., and Norekvaal, T. M.

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Generic medicines are bioequivalents to brand-name medicines, and compelling evidence for the safety and efficacy of generic medicines exists. However, negative perceptions about generic medicines can potentially reduce adherence to prescribed therapy and thereby efficacy of the treatment. Purpose To describe patients' perceptions of generic medicines after percutaneous coronary intervention (PCI), and to investigate the association between perceptions and sociodemographic and clinical factors. Furthermore, we sought to investigate if these perceptions change over time. Methods CONCARDPCI is a large-scale prospective multicentre cohort study on 3251 patients after PCI. The study was conducted between June 2017 and May 2020 at seven large referral PCI centres in Norway and Denmark. Clinical data, including invasive procedures and patient characteristics, were collected from the patients' medical records. Sociodemographic characteristics were obtained by self-report during index hospitalization after PCI. Postal or electronic questionnaires comprising questions regarding perceptions of generic medicines were distributed two (T1) and six (T2) months after discharge from hospital to included patients. The time intervals ensured that a sufficient amount of time had passed so that refill of prescriptions was necessary. To investigate perceptions of generic medicines and the associations with sociodemographic and clinical characteristics, logistic regression analysis was performed. Results Most patients were men (78%), married or living with a partner (75%), elderly (mean age 66 years, SD11, range 20–96 years), and 28% were admitted to hospital due to non-ST-segment elevation myocardial infarction. At T1, 70% perceived generic medicines to be as effective, safe (68%), produce the same side effects (64%), and contain the same active ingredients as brand-name medicines (64%). Perceptions of generic medicines were similar at T2. No significant associations were found with age, marital status, living alone, taking ≥5 medications, or participation in cardiac rehabilitation. However, Danish patients (p83,000 Euro (p=0.007), female gender (p Conclusion Approximately one third of the patients had negative perceptions of generic medicines after PCI, and these negative perceptions do not seem to change substantially during the first six months after PCI. As negative perceptions of generic medicines have been found to be a barrier to medication adherence, improving patients' knowledge and confidence in generic medicines after PCI may be pivotal to reach treatment goals set forth by the 2018 ESC/EACTS Guidelines on myocardial revascularization. Funding Acknowledgement Type of funding sources: Other. Main funding source(s): The Western Norway Health Authority

Published
2021

8. 100.03 Routine Invasive Versus Conservative Management of Non-ST Elevation Acute Coronary Syndromes in Patients With Previous Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

Author

Kelham, M., Vyas, R., Rameseshan, R., Rathod, K., de Winter, R.J., de Winter, R.W., Bendz, B., Thiele, H., Hirlekar, G., Morici, N., Myat, A., Michalis, L., Sanchis, J., Kunadian, V., Berry, C., Mathur, A., and Jones, D.

Published
2024
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9. Plaque and remodeling markers in coronary thrombi

Author

Nordeng, J, primary, Helseth, R, additional, Aakra, S, additional, Hoffmann, P, additional, Schandiz, H, additional, Roald, B, additional, Bendz, B, additional, Arnesen, H, additional, Solheim, S, additional, and Seljeflot, I, additional

Published
2021
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15. Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: findings from the Norwegian coronary stent trial (NORSTENT)

Author

Samuelsen, P, primary, Eggen, A.E, additional, Steigen, T, additional, Wilsgaard, T, additional, Kristensen, A, additional, Skogsholm, A, additional, Holme, E, additional, Van Den Heuvel, C, additional, Nordrehaug, J.E, additional, Bendz, B, additional, Nilsen, D.W.T, additional, and Bonaa, K.H, additional

Published
2020
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20. Serum phospholipids are the main environmental determinants of activated factor VII in the most common FVII genotype. European Union Concerted Action 'Clotart'

Author

Mariani G, Bernardi F, Bertina R, Vv, Vicente, Prydz H, Samama M, Pm, Sandset, Gd, Di Nucci, Mg, Testa, Bendz B, Flavia Chiarotti, Mv, Ciarla, and Strom R

Subjects
Adult, Male, Polymorphism, Genetic, Sex Factors, Age Factors, Humans, Female, Factor VIIa, Factor VII, Middle Aged, Alleles, Phospholipids, Aged
Abstract

Numerous studies have emphasized the role of triglyceride-rich lipoproteins and of Factor VII (FVII) polymorphisms in determining levels of FVII activity.This study was undertaken to evaluate the role of other lipid fractions and the interaction between lipids and FVII in subjects with recognised genotypes. Volunteer subjects (n=459) from 5 European countries were studied. Blood samples were drawn irrespective of the time of day or fasting status. Levels of FVII activity (FVIIc), activated FVII (FVIIa) and FVII antigen (FVIIAg) were evaluated with reference to a number of lipid parameters (HDL-, LDL- and total cholesterol, triglycerides, phospholipids, lipoprotein(a), and apoliproptein A1). The two most common FVII polymorphisms were analyzed in combination (353R/Q and 5'F7; alleles M1/M2 and A1/A2, respectively).Homozygotes for the A1 and M1 alleles (M11/A11) had significantly higher FVII levels. At multiple regression analysis the strongest predictor of FVIIa and FVIIc was the concentration of phospholipids. This interaction was confined to the A11M11 genotype subjects.These data indicate that lipids contribute mainly to FVIIa levels through their phospholipid content, and that the degree of this contribution is strictly dependent on FVII genotypes.

Published
1999

21. Poster Session 4: Friday 9 December 2011, 14:00-18:00 * Location: Poster Area

Author

Wang, M., primary, Yan, G., additional, Yue, W., additional, Siu, C., additional, Tse, H., additional, Perperidis, A., additional, Cusack, D., additional, White, A., additional, Macgillivray, T., additional, Mcdicken, W., additional, Anderson, T., additional, Ryabov, V., additional, Shurupov, V., additional, Suslova, T., additional, Markov, V., additional, Elmstedt, N., additional, Ferm Widlund, K., additional, Lind, B., additional, Brodin, L.-A., additional, Westgren, M., additional, Mantovani, F., additional, Barbieri, A., additional, Bursi, F., additional, Valenti, C., additional, Quaglia, M., additional, Modena, M., additional, Peluso, D., additional, Muraru, D., additional, Dal Bianco, L., additional, Beraldo, M., additional, Solda', E., additional, Tuveri, M., additional, Cucchini, U., additional, Al Mamary, A., additional, Badano, L., additional, Iliceto, S., additional, Goncalves, A., additional, Almeria, C., additional, Marcos-Alberca, P., additional, Feltes, G., additional, Hernandez-Antolin, R., additional, Rodriguez, H., additional, Maroto, L., additional, Silva Cardoso, J., additional, Macaya, C., additional, Zamorano, J., additional, Squarciotta, S., additional, Innocenti, F., additional, Guzzo, A., additional, Bianchi, S., additional, Lazzeretti, D., additional, De Villa, E., additional, Vicidomini, S., additional, Del Taglia, B., additional, Donnini, C., additional, Pini, R., additional, Mennie, C., additional, Salmasi, A. M., additional, Kutyifa, V., additional, Nagy, V., additional, Edes, E., additional, Apor, A., additional, Merkely, B., additional, Nyrnes, S., additional, Lovstakken, L., additional, Torp, H., additional, Haugen, B., additional, Said, K., additional, Shehata, A., additional, Ashour, Z., additional, El-Tobgy, S., additional, Cameli, M., additional, Bigio, E., additional, Lisi, M., additional, Righini, F., additional, Franchi, F., additional, Scolletta, S., additional, Mondillo, S., additional, Gayat, E., additional, Weinert, L., additional, Yodwut, C., additional, Mor-Avi, V., additional, Lang, R., additional, Hrynchyshyn, N., additional, Kachenoura, N., additional, Diebold, B., additional, Khedim, R., additional, Senesi, M., additional, Redheuil, A., additional, Mousseaux, E., additional, Perdrix, L., additional, Yurdakul, S., additional, Erdemir, V., additional, Tayyareci, Y., additional, Memic, K., additional, Yildirimturk, O., additional, Aytekin, V., additional, Gurel, M., additional, Aytekin, S., additional, Gargani, L., additional, Fernandez Cimadevilla, C., additional, La Falce, S., additional, Landi, P., additional, Picano, E., additional, Sicari, R., additional, Smedsrud, M. K., additional, Gravning, J., additional, Eek, C., additional, Morkrid, L., additional, Skulstad, H., additional, Aaberge, L., additional, Bendz, B., additional, Kjekshus, J., additional, Edvardsen, T., additional, Bajraktari, G., additional, Hyseni, V., additional, Morina, B., additional, Batalli, A., additional, Tafarshiku, R., additional, Olloni, R., additional, Henein, M., additional, Mjolstad, O., additional, Snare, S., additional, Folkvord, L., additional, Helland, F., additional, Haraldseth, O., additional, Grimsmo, A., additional, Berry, M., additional, Zaghden, O., additional, Nahum, J., additional, Macron, L., additional, Lairez, O., additional, Damy, T., additional, Bensaid, A., additional, Dubois Rande, J., additional, Gueret, P., additional, Lim, P., additional, Nciri, N., additional, Issaoui, Z., additional, Tlili, C., additional, Wanes, I., additional, Foudhil, H., additional, Dachraoui, F., additional, Grapsa, J., additional, Dawson, D., additional, Nihoyannopoulos, P., additional, Gianturco, L., additional, Turiel, M., additional, Atzeni, F., additional, Sarzi-Puttini, P., additional, Stella, D., additional, Donato, L., additional, Tomasoni, L., additional, Jung, P., additional, Mueller, M., additional, Huber, T., additional, Sevilmis, G., additional, Kroetz, F., additional, Sohn, H., additional, Panoulas, V., additional, Bratsas, A., additional, Raso, R., additional, Tartarisco, G., additional, Pioggia, G., additional, Gargiulo, P., additional, Petretta, M., additional, Cuocolo, A., additional, Prastaro, M., additional, D'amore, C., additional, Vassallo, E., additional, Savarese, G., additional, Marciano, C., additional, Paolillo, S., additional, Perrone Filardi, P., additional, Aggeli, C., additional, Felekos, I., additional, Roussakis, G., additional, Poulidakis, E., additional, Pietri, P., additional, Toutouzas, K., additional, Stefanadis, C., additional, Kaladaridis, A., additional, Skaltsiotis, I., additional, Kottis, G., additional, Bramos, D., additional, Takos, D., additional, Matthaios, I., additional, Agrios, I., additional, Papadopoulou, E., additional, Moulopoulos, S., additional, Toumanidis, S., additional, Carrilho-Ferreira, P., additional, Cortez-Dias, N., additional, Jorge, C., additional, Silva, D., additional, Silva Marques, J., additional, Placido, R., additional, Santos, L., additional, Ribeiro, S., additional, Fiuza, M., additional, Pinto, F., additional, Stoickov, V., additional, Ilic, S., additional, Deljanin Ilic, M., additional, Kim, W., additional, Woo, J., additional, Bae, J., additional, Kim, K., additional, Descalzo, M., additional, Rodriguez, J., additional, Moral, S., additional, Otaegui, I., additional, Mahia, P., additional, Garcia Del Blanco, L., additional, Gonzalez Alujas, T., additional, Figueras, J., additional, Evangelista, A., additional, Garcia-Dorado, D., additional, Takeuchi, M., additional, Kaku, K., additional, Otani, K., additional, Iwataki, M., additional, Kuwaki, H., additional, Haruki, N., additional, Yoshitani, H., additional, Otsuji, Y., additional, Kukucka, M., additional, Pasic, M., additional, Unbehaun, A., additional, Dreysse, S., additional, Mladenow, A., additional, Kuppe, H., additional, Hetzer, R., additional, Rajamannan, N., additional, Tanrikulu, A., additional, Kristiansson, L., additional, Gustafsson, S., additional, Lindmark, K., additional, Henein, M. Y., additional, Evdoridis, C., additional, Stougiannos, P., additional, Thomopoulos, M., additional, Fosteris, M., additional, Spanos, P., additional, Sionis, G., additional, Giatsios, D., additional, Paschalis, A., additional, Sakellaris, C., additional, Trikas, A., additional, Yong, Z. Y., additional, Boerlage-Van Dijk, K., additional, Koch, K., additional, Vis, M., additional, Bouma, B., additional, Piek, J., additional, Baan, J., additional, Abid, L., additional, Frikha, Z., additional, Makni, K., additional, Maazoun, N., additional, Abid, D., additional, Hentati, M., additional, Kammoun, S., additional, Barbier, P., additional, Staron, A., additional, Cefalu', C., additional, Berna, G., additional, Gripari, P., additional, Andreini, D., additional, Pontone, G., additional, Pepi, M., additional, Ring, L., additional, Rana, B., additional, Ho, S., additional, Wells, F., additional, Dogan, A., additional, Karaca, O., additional, Guler, G., additional, Guler, E., additional, Gunes, H., additional, Alizade, E., additional, Agus, H., additional, Gol, G., additional, Esen, O., additional, Esen, A., additional, Turkmen, M., additional, Agricola, E., additional, Ingallina, G., additional, Ancona, M., additional, Maggio, S., additional, Slavich, M., additional, Tufaro, V., additional, Oppizzi, M., additional, Margonato, A., additional, Orsborne, C., additional, Irwin, B., additional, Pearce, K., additional, Ray, S., additional, Garcia Alonso, C., additional, Vallejo, N., additional, Labata, C., additional, Lopez Ayerbe, J., additional, Teis, A., additional, Ferrer, E., additional, Nunez Aragon, R., additional, Gual, F., additional, Pedro Botet, M., additional, Bayes Genis, A., additional, Santos, C. M., additional, Carvalho, M., additional, Andrade, M., additional, Dores, H., additional, Madeira, S., additional, Cardoso, G., additional, Ventosa, A., additional, Aguiar, C., additional, Ribeiras, R., additional, Mendes, M., additional, Petrovic, M., additional, Milasinovic, G., additional, Vujisic-Tesic, B., additional, Nedeljkovic, I., additional, Zamaklar-Trifunovic, D., additional, Petrovic, I., additional, Draganic, G., additional, Banovic, M., additional, Boricic, M., additional, Villarraga, H., additional, Molini-Griggs Bs, C., additional, Silen-Rivera Bs, P., additional, Payne Mph Ms, B., additional, Koshino Md Phd, Y., additional, Hsiao Md, J., additional, Monivas Palomero, V., additional, Mingo Santos, S., additional, Mitroi, C., additional, Garcia Lunar, I., additional, Garcia Pavia, P., additional, Castro Urda, V., additional, Toquero, J., additional, Gonzalez Mirelis, J., additional, Cavero Gibanel, M., additional, Fernandez Lozano, I., additional, Oko-Sarnowska, Z., additional, Wachowiak-Baszynska, H., additional, Katarzynska-Szymanska, A., additional, Trojnarska, O., additional, Grajek, S., additional, Bellavia, D., additional, Pellikka, P., additional, Dispenzieri, A., additional, Oh, J. K., additional, Polizzi, V., additional, Pitrolo, F., additional, Musumeci, F., additional, Miller, F., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Severino, S., additional, Cavallaro, C., additional, Vecchione, F., additional, D'onofrio, A., additional, Calabro', R., additional, Maceira Gonzalez, A. M., additional, Ripoll, C., additional, Cosin-Sales, J., additional, Igual, B., additional, Salazar, J., additional, Belloch, V., additional, Cosin-Aguilar, J., additional, Pinamonti, B., additional, Iorio, A., additional, Bobbo, M., additional, Merlo, M., additional, Barbati, G., additional, Massa, L., additional, Faganello, G., additional, Di Lenarda, A., additional, Sinagra, G. F., additional, Ishizu, T., additional, Seo, Y., additional, Enomoto, M., additional, Kameda, Y., additional, Ishibashi, N., additional, Inoue, M., additional, Aonuma, K., additional, Saleh, A., additional, Matsumori, A., additional, Negm, H., additional, Fouad, H., additional, Onsy, A., additional, Hamodraka, E., additional, Paraskevaidis, I., additional, Kallistratos, M., additional, Lezos, V., additional, Zamfir, T., additional, Manetos, C., additional, Mavropoulos, D., additional, Poulimenos, L., additional, Kremastinos, D., additional, Manolis, A., additional, Citro, R., additional, Rigo, F., additional, Ciampi, Q., additional, Patella, M., additional, Provenza, G., additional, Zito, C., additional, Tagliamonte, E., additional, Rotondi, F., additional, Silvestri, F., additional, Bossone, E., additional, Beltran Correas, P., additional, Gutierrez Landaluce, C., additional, Gomez Bueno, M., additional, Segovia Cubero, J., additional, Beladan, C., additional, Matei, F., additional, Popescu, B., additional, Calin, A., additional, Rosca, M., additional, Boanta, A., additional, Enache, R., additional, Savu, O., additional, Usurelu, C., additional, Ginghina, C., additional, Ciobanu, A. O., additional, Dulgheru, R., additional, Magda, S., additional, Dragoi, R., additional, Florescu, M., additional, Vinereanu, D., additional, Robalo Martins, S., additional, Calisto, C., additional, Goncalves, S., additional, Barrigoto, I., additional, Carvalho De Sousa, J., additional, Almeida, A., additional, Nunes Diogo, A., additional, Sargento, L., additional, Satendra, M., additional, Sousa, C., additional, Lousada, N., additional, Palma Reis, R., additional, Schiano Lomoriello, V., additional, Esposito, R., additional, Santoro, A., additional, Raia, R., additional, Schiattarella, P., additional, Dores, E., additional, Galderisi, M., additional, Mansencal, N., additional, Caille, V., additional, Dupland, A., additional, Perrot, S., additional, Bouferrache, K., additional, Vieillard-Baron, A., additional, Jouffroy, R., additional, Moceri, P., additional, Liodakis, E., additional, Gatzoulis, M., additional, Li, W., additional, Dimopoulos, K., additional, Sadron, M., additional, Seguela, P. E., additional, Arnaudis, B., additional, Dulac, Y., additional, Cognet, T., additional, Acar, P., additional, Shiina, Y., additional, Uemura, H., additional, Kupczynska, K., additional, Kasprzak, J., additional, Michalski, B., additional, Lipiec, P., additional, Carvalho, V., additional, Almeida, A. M. G., additional, David, C., additional, Marques, J., additional, Ferreira, P., additional, Amaro, M., additional, Costa, P., additional, Diogo, A., additional, Tritakis, V., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tzortzis, S., additional, Kadoglou, N., additional, Papadakis, I., additional, Trivilou, P., additional, Koukoulis, C., additional, Anastasiou-Nana, M., additional, Bombardini, T., additional, Gherardi, S., additional, Arpesella, G., additional, Maccherini, M., additional, Serra, W., additional, Magnani, G., additional, Del Bene, R., additional, Pasanisi, E., additional, Startari, U., additional, Panchetti, L., additional, Rossi, A., additional, Piacenti, M., additional, Morales, M., additional, El Hajjaji, I., additional, El Mahmoud, R., additional, Digne, F., additional, Dubourg, O., additional, Agoston, G., additional, Moreo, A., additional, Pratali, L., additional, Moggi Pignone, A., additional, Pavellini, A., additional, Doveri, M., additional, Musca, F., additional, Varga, A., additional, Faita, F., additional, Rimoldi, S., additional, Sartori, C., additional, Alleman, Y., additional, Salinas Salmon, C., additional, Villena, M., additional, Scherrer, U., additional, Baptista, R., additional, Serra, S., additional, Castro, G., additional, Martins, R., additional, Salvador, M., additional, Monteiro, P., additional, Silva, J., additional, Szudi, L., additional, Temesvary, A., additional, Fekete, B., additional, Kassai, I., additional, Szekely, L., additional, Abdel Moneim, S. S., additional, Martinez, M., additional, Mankad, S., additional, Bernier, M., additional, Dhoble, A., additional, Chandrasekaran, K., additional, Oh, J., additional, Mulvagh, S., additional, Hong, G. R., additional, Kim, J. Y., additional, Lee, S. C., additional, Choi, S. H., additional, Sohn, I. S., additional, Seo, H. S., additional, Choi, J. H., additional, Cho, K. I., additional, Yoon, S. J., additional, Lim, S. J., additional, Wejner-Mik, P., additional, Kusmierek, J., additional, Plachcinska, A., additional, Szuminski, R., additional, Stoebe, S., additional, Tarr, A., additional, Trache, T., additional, Hagendorff, A., additional, Jenkins, C., additional, Kuhl, H., additional, Nesser, H., additional, Marwick, T., additional, Franke, A., additional, Niel, J., additional, Sugeng, L., additional, Soderberg, S., additional, Lindqvist, P., additional, Necas, J., additional, Kovalova, S., additional, Saha, S. K., additional, Kiotsekoglou, A., additional, Toole, R., additional, Govind, S., additional, Gopal, A., additional, Amzulescu, M.-S., additional, Florian, A., additional, Bogaert, J., additional, Janssens, S., additional, Voigt, J., additional, Parisi, V., additional, Losi, M., additional, Parrella, L., additional, Contaldi, C., additional, Chiacchio, E., additional, Caputi, A., additional, Scatteia, A., additional, Buonauro, A., additional, Betocchi, S., additional, Rimbas, R., additional, Mihaila, S., additional, Caputo, M., additional, Navarri, R., additional, Innelli, P., additional, Urselli, R., additional, Capati, E., additional, Ballo, P., additional, Furiozzi, F., additional, Favilli, R., additional, Lindquist, R., additional, Miller, A., additional, Reece, C., additional, O'leary, P., additional, Cetta, F., additional, Eidem, B. W., additional, Cikes, M., additional, Gasparovic, H., additional, Bijnens, B., additional, Velagic, V., additional, Kopjar, T., additional, Biocina, B., additional, Milicic, D., additional, Ta-Shma, A., additional, Nir, A., additional, Perles, Z., additional, Gavri, S., additional, Golender, J., additional, Rein, A., additional, Pinnacchio, G., additional, Barone, L., additional, Battipaglia, I., additional, Cosenza, A., additional, Marinaccio, L., additional, Coviello, I., additional, Scalone, G., additional, Sestito, A., additional, Lanza, G., additional, Crea, F., additional, Cakal, S., additional, Eroglu, E., additional, Ozkan, B., additional, Kulahcioglu, S., additional, Bulut, M., additional, Koyuncu, A., additional, Acar, G., additional, Alici, G., additional, Dundar, C., additional, Labombarda, F., additional, Zangl, E., additional, Pellissier, A., additional, Bougle, D., additional, Maragnes, P., additional, Milliez, P., additional, Saloux, E., additional, Lagoudakou, S., additional, Gialafos, E., additional, Tsokanis, A., additional, Nagy, A., additional, Kovats, T., additional, Vago, H., additional, Toth, A., additional, Sax, B., additional, Kovacs, A., additional, Elnoamany, M. F., additional, Badran, H., additional, Abdelfattah, I., additional, Khalil, T., additional, Salama, M., additional, Butz, T., additional, Taubenberger, C., additional, Thangarajah, F., additional, Meissner, A., additional, Van Bracht, M., additional, Prull, M., additional, Yeni, H., additional, Plehn, G., additional, Trappe, H., additional, Rydman, R., additional, Bone, D., additional, Alam, M., additional, Caidahl, K., additional, Larsen, F., additional, Gasior, Z., additional, Tabor, Z., additional, Sengupta, P., additional, Liu, D., additional, Niemann, M., additional, Hu, K., additional, Herrmann, S., additional, Stoerk, S., additional, Morbach, C., additional, Knop, S., additional, Voelker, W., additional, Ertl, G., additional, Weidemann, F., additional, Cawley, P., additional, Hamilton-Craig, C., additional, Mitsumori, L., additional, Maki, J., additional, Otto, C., additional, Astrom Aneq, M., additional, Nylander, E., additional, Ebbers, T., additional, Engvall, J., additional, Arvanitis, P., additional, Flachskampf, F., additional, Duvernoy, O., additional, De Torres Alba, F., additional, Valbuena Lopez, S., additional, Guzman Martinez, G., additional, Gomez De Diego, J., additional, Rey Blas, J., additional, Armada Romero, E., additional, Lopez De Sa, E., additional, Moreno Yanguela, M., additional, Lopez Sendon, J., additional, Trikalinos, N., additional, Siasos, G., additional, Aggeli, A., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Vriz, O., additional, Driussi, C., additional, Bettio, M., additional, Pavan, D., additional, Antonini Canterin, F., additional, Doltra Magarolas, A., additional, Fernandez-Armenta, J., additional, Silva, E., additional, Solanes, N., additional, Rigol, M., additional, Barcelo, A., additional, Mont, L., additional, Berruezo, A., additional, Brugada, J., additional, Sitges, M., additional, Ciciarello, F. L., additional, Mandolesi, S., additional, Fedele, F., additional, Agati, L., additional, Marceca, A., additional, Rhee, S., additional, Shin, S., additional, Kim, S., additional, Yun, K., additional, Yoo, N., additional, Kim, N., additional, Oh, S., additional, Jeong, J., additional, and Alabdulkarim, N., additional

Published
2011
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22. Poster Session 1: Thursday 8 December 2011, 08:30-12:30 * Location: Poster Area

Author

Vijayan, S., primary, Khanji, M., additional, Ionescu, A., additional, Vijayan, S., additional, Podoleanu, C., additional, Frigy, A., additional, Ugri, A., additional, Varga, A., additional, Podoleanu, D., additional, Incze, A., additional, Carasca, E., additional, Dobreanu, D., additional, Mjolstad, O., additional, Dalen, H., additional, Graven, T., additional, Kleinau, J., additional, Hagen, B., additional, Fu, H., additional, Liu, T., additional, Li, J., additional, Liu, C., additional, Zhou, C., additional, Li, G., additional, Bordese, R., additional, Capriolo, M., additional, Brero, D., additional, Salvetti, I., additional, Cannillo, M., additional, Antolini, M., additional, Grosso Marra, W., additional, Frea, S., additional, Morello, M., additional, Gaita, F., additional, Maffessanti, F., additional, Caiani, E., additional, Muraru, D., additional, Tuveri, F., additional, Dal Bianco, L., additional, Badano, L., additional, Majid, A., additional, Soesanto, A., additional, Ario Suryo Kuncoro, B., additional, Sukmawan, R., additional, Ganesja, M. H., additional, Benedek, T., additional, Chitu, M., additional, Beata, J., additional, Suciu, Z., additional, Kovacs, I., additional, Bucur, O., additional, Benedek, I., additional, Hrynkiewicz-Szymanska, A., additional, Szymanski, F., additional, Karpinski, G., additional, Filipiak, K., additional, Radunovic, Z., additional, Lande Wekre, L., additional, Steine, K., additional, Bech-Hanssen, O., additional, Rundqvist, B., additional, Lindgren, F., additional, Selimovic, N., additional, Jedrzychowska-Baraniak, J., additional, Jozwa, R., additional, Larysz, B., additional, Kasprzak, J., additional, Ripp, T., additional, Mordovin, V., additional, Ripp, E., additional, Ciobanu, A., additional, Dulgheru, R., additional, Dragoi, R., additional, Magda, S., additional, Florescu, M., additional, Mihaila, S., additional, Rimbas, R., additional, Cinteza, M., additional, Vinereanu, D., additional, Benavides-Vallve, C., additional, Pelacho, B., additional, Iglesias, O., additional, Castano, S., additional, Munoz-Barrutia, A., additional, Prosper, F., additional, Ortiz De Solorzano, C., additional, Manouras, A., additional, Sahlen, A., additional, Winter, R., additional, Vardas, P., additional, Brodin, L., additional, Sarvari, S. I., additional, Haugaa, K. H., additional, Zahid, W., additional, Bendz, B., additional, Aaberge, L., additional, Edvardsen, T., additional, Di Bella, G., additional, Pedri, S., additional, Donato, R., additional, Madaffari, A., additional, Zito, C., additional, Stapf, D., additional, Schreckenberg, M., additional, Carerj, S., additional, Yoshikawa, H., additional, Suzuki, M., additional, Kusunose, Y., additional, Hashimoto, G., additional, Otsuka, T., additional, Nakamura, M., additional, Sugi, K., additional, Grapsa, J., additional, Dawson, D., additional, Gin-Sing, W., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Smith, B., additional, Coulter, T., additional, Rendon, A., additional, Gorissen, W., additional, Shiran, A., additional, Asmer, I., additional, Adawi, S., additional, Ganaeem, M., additional, Shehadeh, J., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Maccherini, M., additional, Sani, G., additional, Galderisi, M., additional, Mondillo, S., additional, Kalimanovska-Ostric, D., additional, Nastasovic, T., additional, Jovanovic, I., additional, Milakovic, B., additional, Dostanic, M., additional, Stosic, M., additional, Sasic, I., additional, Sveen, K., additional, Nerdrum, T., additional, Hanssen, K., additional, Dahl-Jorgensen, K., additional, Holte, E., additional, Vegsundvaag, J., additional, Hole, T., additional, Hegbom, K., additional, Wiseth, R., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tritakis, V., additional, Papadakis, I., additional, Kadoglou, N., additional, Tzortzis, S., additional, Trivilou, P., additional, Koukoulis, C., additional, Paraskevaidis, I., additional, Anastasiou-Nana, M., additional, Smedsrud, M. K., additional, Sarvari, S., additional, Gjesdal, O., additional, Beraldo, M., additional, Solda', E., additional, Cucchini, U., additional, Peluso, D., additional, Tuveri, M., additional, Al Mamary, A., additional, Iliceto, S., additional, Dores, H., additional, Abecasis, J., additional, Carvalho, M., additional, Santos, M., additional, Andrade, M., additional, Ribeiras, R., additional, Reis, C., additional, Horta, E., additional, Gouveia, R., additional, Mendes, M., additional, Zaliaduonyte-Peksiene, D., additional, Mizariene, V., additional, Cesnaite, G., additional, Tamuleviciute, E., additional, Jurkevicius, R., additional, Vaskelyte, J., additional, Zaliunas, R., additional, Smarz, K., additional, Zaborska, B., additional, Jaxa-Chamiec, T., additional, Maciejewski, P., additional, Budaj, A., additional, Trifunovic, D., additional, Sobic-Saranovic, D., additional, Stankovic, S., additional, Ostojic, M., additional, Vujisic-Tesic, B., additional, Petrovic, M., additional, Nedeljkovic, I., additional, Banovic, M., additional, Tesic, M., additional, Petrovic, I., additional, Peovska, I., additional, Srbinovska, E., additional, Maksimovic, J., additional, Andova, V., additional, Arnaudova, F., additional, Hristova, E., additional, Otljanska, M., additional, Vavlukis, M., additional, Jovanova, S., additional, Tamborini, G., additional, Fusini, L., additional, Gripari, P., additional, Muratori, M., additional, Pontone, G., additional, Andreini, D., additional, Bertella, E., additional, Ghulam Ali, S., additional, Bartorelli, A., additional, Pepi, M., additional, Cusma-Piccione, M., additional, Salvia, J., additional, Antonini-Canterin, F., additional, Lentini, S., additional, Donato, D., additional, Miceli, M., additional, Oreto, G., additional, Sachner, R., additional, Rubinshtein, R., additional, Shnapp, M., additional, Gaspar, T., additional, Marchese, A., additional, Deste, W., additional, Sanfilippo, A., additional, Aruta, P., additional, Patane, M., additional, Millan, G., additional, Ussia, G., additional, Tamburino, C., additional, Kujacic, V., additional, Obradovic, S., additional, Crkvenac, Z., additional, Bernard, A., additional, Piquemal, M., additional, Muller, G., additional, Arbeille, P., additional, Charbonnier, B., additional, Broyd, C., additional, Davies, J., additional, Mikhail, G., additional, Mayet, J., additional, Francis, D., additional, Rosca, M., additional, Magne, J., additional, Szymanski, C., additional, Popescu, B., additional, Ginghina, C., additional, Pierard, L., additional, Lancellotti, P., additional, Gonzalez-Mansilla, A., additional, Solis, J., additional, Angulo, R., additional, Perez-David, E., additional, Madrid, G., additional, Garcia-Robles, J., additional, Yotti, R., additional, Prieto, R., additional, Bermejo, J., additional, Fernandez-Aviles, F., additional, Ishikawa, Y., additional, Ishida, T., additional, Osaki, T., additional, Matsuyama, M., additional, Yamashita, H., additional, Ozaki, S., additional, Stevanella, M., additional, Votta, E., additional, Veronesi, F., additional, Alamanni, F., additional, Redaelli, A., additional, Park, S. D., additional, Lee, J., additional, Shin, S., additional, Woo, S., additional, Kim, D., additional, Park, K., additional, Kwan, J., additional, Tsang, W., additional, Chandra, S., additional, Weinert, L., additional, Gayat, E., additional, Djelassi, M., additional, Balbach, T., additional, Mor-Avi, V., additional, Lang, R., additional, De Meester, P., additional, Van De Bruaene, A., additional, Delcroix, M., additional, Budts, W., additional, Abid, L., additional, Frikha, Z., additional, Makni, K., additional, Rekik, H., additional, Znazen, A., additional, Mourad, H., additional, Kammoun, S., additional, Sargento, L., additional, Satendra, M., additional, Sousa, C., additional, Lopes, S., additional, Longo, S., additional, Lousada, N., additional, Palma Reis, R., additional, Fouad, D., additional, Shams Eldeen, R., additional, Beladan, C., additional, Calin, A., additional, Voinea, F., additional, Enache, R., additional, Jurcut, R., additional, Coman, I., additional, Ghionea, M., additional, Djordjevic-Dikic, A., additional, Petrovic, O., additional, Boricic, M., additional, Giga, V., additional, Pisciella, L., additional, Lanzillo, C., additional, Minati, M., additional, Caselli, S., additional, Di Roma, M., additional, Fratini, S., additional, Romano, S., additional, Calo', L., additional, Lioy, E., additional, Penco, M., additional, Finocchiaro, G., additional, Pinamonti, B., additional, Merlo, M., additional, Barbati, G., additional, Sinagra, G., additional, Dilenarda, A., additional, Comenale Pinto, S., additional, Ancona, R., additional, Caso, P., additional, Cavallaro, C., additional, Vecchione, F., additional, D'onofrio, A., additional, Fero', M., additional, Calabro', R., additional, Gustafsson, S., additional, Ihse, E., additional, Henein, M., additional, Westermark, P., additional, Suhr, O., additional, Lindqvist, P., additional, Oliva Sandoval, M., additional, Gonzalez Carrillo, M., additional, Garcia Navarro, M., additional, Garcia-Molina Saez, E., additional, Sabater Molina, M., additional, Saura Espin, D., additional, Lacunza Ruiz, J., additional, Gimeno Blanes, J., additional, De La Morena Valenzuela, G., additional, Valdes Chavarri, M., additional, Prinz, C., additional, Faber, L., additional, Horstkotte, D., additional, Hoetz, H., additional, Voigt, J., additional, Gandara, F., additional, Correia, M., additional, Rosario, I., additional, Fonseca, C., additional, Arroja, I., additional, Aleixo, A., additional, Martins, A., additional, Radulescu, L., additional, Dan Radulescu, D., additional, Parv Andreea, P., additional, Duncea Caius, D., additional, Ciuleanu T, C., additional, Mitrea Paulina, M., additional, Cali Quaglia, F., additional, Ribezzo, M., additional, Boffini, M., additional, Rinaldi, M., additional, Maceira Gonzalez, A. M., additional, Cosin-Sales, J., additional, Dalli, E., additional, Diago, J., additional, Aguilar, J., additional, Ruvira, J., additional, Goncalves, S., additional, Gomes, A., additional, Pinto, F., additional, Tsai, W.-C., additional, Liu, Y.-W., additional, Shih, J.-Y., additional, Huang, Y.-Y., additional, Chen, J.-Y., additional, Tsai, L.-M., additional, Chen, J.-H., additional, Ribeiro, S., additional, Doroteia, D., additional, Santos, L., additional, David, C., additional, Vinhas De Sousa, G., additional, Almeida, A., additional, Iwase, M., additional, Itou, Y., additional, Yasukochi, S., additional, Shiino, K., additional, Inuzuka, H., additional, Sugimoto, K., additional, Ozaki, Y., additional, Gieszczyk-Strozik, K., additional, Sikora-Puz, A., additional, Mizia, M., additional, Lasota, B., additional, Chmiel, A., additional, Lis-Swiety, A., additional, Michna, J., additional, Brzezinska-Wcislo, L., additional, Mizia-Stec, K., additional, Gasior, Z., additional, Luijendijk, P., additional, De Bruin-Bon, H., additional, Zwiers, C., additional, Vriend, J., additional, Van Den Brink, R., additional, Mulder, B., additional, Bouma, B., additional, Brigido, S., additional, Gianfagna, P., additional, Proclemer, A., additional, Plicht, B., additional, Kahlert, P., additional, Kaelsch, H., additional, Buck, T., additional, Erbel, R., additional, Konorza, T., additional, Yoon, H., additional, Kim, K., additional, Ahn, Y., additional, Jeong, M., additional, Cho, J., additional, Park, J., additional, Kang, J., additional, Rha, W., additional, Jansen Klomp, W. W., additional, Brandon Bravo Bruinsma, G., additional, Van 'T Hof, A., additional, Spanjersberg, S., additional, Nierich, A., additional, Bombardini, T., additional, Gherardi, S., additional, Picano, E., additional, Ciarka, A., additional, Herbots, L., additional, Eroglu, E., additional, Van Cleemput, J., additional, Droogne, W., additional, Jasityte, R., additional, Meyns, B., additional, D'hooge, J., additional, Vanhaecke, J., additional, Al Barjas, M., additional, Iskreva, R., additional, Morris, R., additional, Davar, J., additional, Zhao, Y., additional, Holmgren, A., additional, Morner, S., additional, Stepanovic, J., additional, Beleslin, B., additional, Nedeljkovic, M., additional, Mazic, S., additional, Stojanov, V., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Eibel, S., additional, Hasheminejad, E., additional, Mukherjee, C., additional, Tschernich, H., additional, Ender, J., additional, Delithanasis, I., additional, Celutkiene, J., additional, Kenny, C., additional, Monaghan, M., additional, Van Den Oord, S., additional, Ten Kate, G., additional, Akkus, Z., additional, Renaud, G., additional, Sijbrands, E., additional, Ten Cate, F., additional, De Jong, N., additional, Bosch, J., additional, Van Der Steen, A., additional, Schinkel, A., additional, Lisowska, A., additional, Knapp, M., additional, Tycinska, A., additional, Sawicki, R., additional, Kralisz, P., additional, Sobkowicz, B., additional, Chang, S.-A., additional, Lee, S.-C., additional, Kim, E.-Y., additional, Hahm, S.-H., additional, Ahn, G.-T., additional, Sohn, M.-K., additional, Park, S.-J., additional, Choi, J.-O., additional, Park, S.-W., additional, Oh, J.-K., additional, Gursoy, M. O., additional, Gokdeniz, T., additional, Astarcioglu, M., additional, Bayram, Z., additional, Cakal, B., additional, Karakoyun, S., additional, Kalcik, M., additional, Kahveci, G., additional, Yildiz, M., additional, Ozkan, M., additional, Skidan, V., additional, Borowski, A., additional, Park, M., additional, Thomas, J., additional, Ranjbar, S., additional, Hassantash, S., additional, Karvandi, M., additional, Foroughi, M., additional, Davidsen, E. S., additional, Cramariuc, D., additional, Bleie, O., additional, Gerdts, E., additional, Matre, K., additional, Cusma' Piccione, M., additional, Bagnato, G., additional, Mohammed, M., additional, Piluso, S., additional, Oreto, L., additional, Bitter, T., additional, Carvalho, S., additional, Canada, M., additional, Santisteban Sanchez De Puerta, M., additional, Mesa Rubio, M. D., additional, Ruiz Ortiz, M., additional, Delgado Ortega, M., additional, Pena Pena, M. L., additional, Puentes Chiachio, M., additional, Suarez De Lezo Cruz-Conde, J., additional, Pan Alvarez-Ossorio, M., additional, Mazuelos Bellido, F., additional, Suarez De Lezo Herreros De Tejada, J., additional, Altekin, E., additional, Yanikoglu, A., additional, Karakas, S., additional, Oncel, C., additional, Akdemir, B., additional, Belgi Yildirim, A., additional, Cilli, A., additional, Yilmaz, H., additional, Lenartowska, L., additional, Furdal, M., additional, Knysz, B., additional, Konieczny, A., additional, Lewczuk, J., additional, Severino, S., additional, Cavallaro, M., additional, Coppola, M., additional, Motoki, H., additional, To, A., additional, Bhargava, M., additional, Wazni, O., additional, Marwick, T., additional, Klein, A., additional, Sinkovskaya, E., additional, Horton, S., additional, Abuhamad, A., additional, Mingo Santos, S., additional, Monivas Palomero, V., additional, Beltran Correas, B., additional, Mitroi, C., additional, Gutierrez Landaluce, C., additional, Garcia Lunar, I., additional, Gonzalez Mirelis, J., additional, Cavero, M., additional, Segovia Cubero, J., additional, Alonso Pulpon, L., additional, Gurel, E., additional, Karaahmet, T., additional, Tigen, K., additional, Kirma, C., additional, Dundar, C., additional, Pala, S., additional, Isiklar, I., additional, Cevik, C., additional, Kilicgedik, A., additional, Basaran, Y., additional, Brambatti, M., additional, Romandini, A., additional, Barbarossa, A., additional, Molini, S., additional, Urbinati, A., additional, Giovagnoli, A., additional, Cipolletta, L., additional, Capucci, A., additional, Park, S., additional, Choi, E., additional, Ahn, C., additional, Hong, S., additional, Kim, M., additional, Lim, D., additional, Shim, W., additional, Xie, J., additional, Fang, F., additional, Zhang, Q., additional, Chan, J., additional, Yip, G., additional, Sanderson, J., additional, Lam, Y., additional, Yan, B., additional, Yu, C., additional, Jorge Perez, P., additional, De La Rosa Hernandez, A., additional, Hernandez Garcia, C., additional, Duque Garcia, A., additional, Barragan Acea, A., additional, Arroyo Ucar, E., additional, Jimenez Rivera, J., additional, Lacalzada Almeida, J., additional, Laynez Cerdena, I., additional, Carminati, C., additional, Capoulade, R., additional, Larose, E., additional, Clavel, M., additional, Dumesnil, J., additional, Arsenault, M., additional, Bedard, E., additional, Mathieu, P., additional, Pibarot, P., additional, Gargani, L., additional, Baldi, G., additional, Forfori, F., additional, Caramella, D., additional, D'errico, L., additional, Abramo, A., additional, Sicari, R., additional, Giunta, F., additional, Lee, W.-N., additional, Larrat, B., additional, Messas, E., additional, Pernot, M., additional, Tanter, M., additional, Velagic, V., additional, Cikes, M., additional, Matasic, R., additional, Skorak, I., additional, Samardzic, J., additional, Puljevic, D., additional, Lovric Bencic, M., additional, Biocina, B., additional, Milicic, D., additional, Roosens, B., additional, Bala, G., additional, Droogmans, S., additional, Hostens, J., additional, Somja, J., additional, Delvenne, E., additional, Schiettecatte, J., additional, Lahoutte, T., additional, Van Camp, G., additional, Cosyns, B., additional, Ghosh, A., additional, Hardy, R., additional, Chaturvedi, N., additional, Deanfield, J., additional, Pellerin, D., additional, Kuh, D., additional, Hughes, A., additional, Malmgren, A., additional, Dencker, M., additional, Stagmo, M., additional, Gudmundsson, P., additional, Seo, Y., additional, Ishizu, T., additional, Aonuma, K., additional, Schuuring, M. J., additional, Vis, J., additional, Van Dijk, A., additional, Van Melle, J., additional, Pieper, P., additional, Vliegen, H., additional, Sieswerda, G., additional, Foukarakis, E., additional, Pitarokilis, A., additional, Kafarakis, P., additional, Kiritsi, A., additional, Klironomos, E., additional, Manousakis, A., additional, Fragiadaki, X., additional, Papadakis, E., additional, and Dermitzakis, A., additional

Published
2011
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23. Poster session I * Thursday 9 December 2010, 08:30-12:30

Author

Kuznetsov, V. A., primary, Kozhurina, A. O., additional, Plusnin, A. V., additional, Szulik, M., additional, Sredniawa, B., additional, Streb, W., additional, Lenarczyk, R., additional, Stabryla-Deska, J., additional, Sedkowska, A., additional, Kowalski, O., additional, Kalarus, Z., additional, Kukulski, T., additional, Katova, T. M., additional, Nesheva, A., additional, Simova, I., additional, Hristova, K., additional, Kostova, V., additional, Boiadjiev, L., additional, Dimitrov, N., additional, Papamichalis Michalis, M. P., additional, Sitafidis George, S. G., additional, Dimopoulos Basilios, B. D., additional, Kelepesis Glafkos, G. K., additional, Economou Dimitrios, D. E., additional, Skoularigis John, J. S., additional, Triposkiadis Filippos, F. T., additional, Attenhofer Jost, C. H., additional, Pfyffer, M., additional, Naegeli, B., additional, Levis, P., additional, Faeh-Gunz, A., additional, Brunner-Larocca, H. P., additional, Velasco Del Castillo, M. S., additional, Cacicedo, A., additional, Onaindia, J. J., additional, Gonzalez Ruiz, J., additional, Subinas, A., additional, Alarcon, J. A., additional, Quintana, O., additional, Rodriguez, I., additional, Laraudogoitia, E., additional, Lam, Y.-Y., additional, Henein, M. Y., additional, Mazzone, A., additional, Vianello, A., additional, Perlini, S., additional, Corciu, A. I., additional, Cappelli, S., additional, Cerillo, A., additional, Chiappino, D., additional, Berti, S., additional, Glauber, M., additional, Herrmann, S., additional, Niemann, M., additional, Stoerk, S., additional, Strotmann, J., additional, Voelker, W., additional, Ertl, G., additional, Weidemann, F., additional, Yong, Z. Y., additional, Boerlage - Van Dijk, K., additional, Koch, K. T., additional, Vis, M. M., additional, Bouma, B. J., additional, Henriques, J. P. S., additional, Cocchieri, R., additional, De Mol, B. A. J. M., additional, Piek, J. J., additional, Baan, J., additional, Keenan, N. G. J., additional, Cueff, C., additional, Cimadevilla, C., additional, Brochet, E., additional, Lepage, L., additional, Detaint, D., additional, Iung, B., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Osaki, T., additional, Tsuchida, T., additional, Matsuyama, M., additional, Yamashita, H., additional, Ozaki, S., additional, Sugi, K., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Ferrer Sistach, E., additional, Camara, M. L., additional, Lopez Ayerbe, J., additional, Bosch Carabante, C., additional, Espriu Simon, M., additional, Gual Capllonch, F., additional, Bayes Genis, A., additional, Deswarte, G., additional, Vanesson, C., additional, Polge, A. S., additional, Huchette, D., additional, Modine, T., additional, Marboeuf, P., additional, Lamblin, N., additional, Bauters, C., additional, Deklunder, G., additional, Le Tourneau, T., additional, Agricola, A., additional, Gullace, M., additional, Stella, S., additional, D'amato, R., additional, Slavich, M., additional, Oppizzi, M., additional, Ancona, M., additional, Margonato, A., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Muratori, M., additional, Montorsi, P., additional, Maffessanti, F., additional, Gripari, P., additional, Teruzzi, G., additional, Ghulam Ali, S., additional, Fusini, L., additional, Celeste, F., additional, Pepi, M., additional, Goebel, B., additional, Haugaa, K., additional, Meyer, K., additional, Otto, S., additional, Lauten, A., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. 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T., additional, Monivas Palomero, V., additional, Mingo Santos, S., additional, Mitroi, C., additional, Garcia Lunar, I., additional, Garcia Pavia, P., additional, Gonzalez Mirelis, J., additional, Ruiz Bautista, L., additional, Castro Urda, V., additional, Toquero Ramos, J., additional, Fernandez Lozano, I., additional, Sommer, A., additional, Poulsen, S. H., additional, Mogensen, J., additional, Thuesen, L., additional, Egeblad, H., additional, Montisci, R., additional, Ruscazio, M., additional, Vacca, A., additional, Garau, P., additional, Tuveri, F., additional, Soro, C., additional, Matthieu, A., additional, Meloni, L., additional, Kosmala, W., additional, Przewlocka-Kosmala, M., additional, Wojnalowicz, A., additional, Mysiak, A., additional, Marwick, T. H., additional, Yotti, R., additional, Ripoll, C., additional, Bermejo, J., additional, Benito, Y., additional, Mombiela, T., additional, Rincon, D., additional, Barrio, A., additional, Banares, R., additional, Fernandez-Aviles, F., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Ticulescu, R., additional, Vriz, O., additional, Sparacino, L., additional, Popescu, B. A., additional, Ginghina, C., additional, Nicolosi, G. L., additional, Carerj, S., additional, Antonini-Canterin, F., additional, Agricola, E., additional, Bertoglio, L., additional, Melissano, G., additional, Chiesa, R., additional, Garcia Blas, S., additional, Iglesias Del Valle, D., additional, Lopez Fernandez, T., additional, Gomez De Diego, J. J., additional, Monedero Martin, M. C., additional, Dominguez, F. J., additional, Moreno Yanguela, M., additional, Lopez Sendon, J. L., additional, Adhya, S., additional, Murgatroyd, F. D., additional, Monaghan, M., additional, Spinarova, L., additional, Meluzin, J., additional, Hude, P., additional, Krejci, J., additional, Podrouzkova, H., additional, Pesl, M., additional, Panovsky, R., additional, Dusek, L., additional, Orban, M., additional, Korinek, J., additional, Hammerstingl, C., additional, Schwiekendik, M., additional, Nickenig, G., additional, Momcilovic, D., additional, Lickfett, L., additional, Beladan, C. C., additional, Calin, A., additional, Rosca, M., additional, Muraru, D., additional, Voinea, F., additional, Popa, E., additional, Matei, F., additional, Curea, F., additional, Di Salvo, G., additional, Pacileo, G., additional, Gala, S., additional, Castaldi, B., additional, D'aiello, A. F., additional, Mormile, A., additional, Baldini, L., additional, Russo, M. G., additional, Calabro, R., additional, Halvorsen, P. S., additional, Dahle, G., additional, Bugge, J. F., additional, Bendz, B., additional, Aaberge, L., additional, Rein, K. A., additional, Fiane, A., additional, Bergsland, J., additional, Fosse, E., additional, Aakhus, S., additional, Koopman, L. P., additional, Chahal, N., additional, Slorach, C., additional, Hui, W., additional, Sarkola, T., additional, Manlhiot, C., additional, Bradley, T. J., additional, Jaeggi, E. T., additional, Mccrindle, B. W., additional, Mertens, L., additional, D'aiello, F. A., additional, Mormilw, A., additional, Rea, A., additional, O'Connor, K., additional, Romano, G., additional, Magne, J., additional, Pierard, L., additional, Lancellotti, P., additional, Arita, T., additional, Ando, K., additional, Isotani, A., additional, Soga, Y., additional, Iwabuchi, M., additional, Nobuyoshi, M., additional, Wiesen, M., additional, Skowasch, D., additional, Breunig, F., additional, Beer, M., additional, Hu, K., additional, Wanner, C., additional, Morel, M. A., additional, Bernard, Y. F., additional, Descotes-Genon, V., additional, Meneveau, N., additional, Schiele, F., additional, Vitarelli, A., additional, Bernardi, M., additional, Scarno, A., additional, Caranci, F., additional, Padella, V., additional, Dettori, O., additional, Capotosto, L., additional, Vitarelli, M., additional, De Cicco, V., additional, Bruno, P., additional, Bajraktari, G., additional, Lindqvist, P., additional, Gustafsson, U., additional, Holmgren, A., additional, Hassan, M., additional, Said, K., additional, Baligh, E., additional, Farouk, H., additional, Osama, D., additional, Elmahdy, M. F., additional, Elfaramawy, A., additional, Sorour, K., additional, Luckie, M., additional, Zaidi, A., additional, Fitzpatrick, A., additional, Khattar, R. S., additional, Schwartz, J., additional, Huttin, O., additional, Popovic, B., additional, Zinzius, P. Y., additional, Christophe, C., additional, Marcon, O., additional, Groben, L., additional, Juilliere, Y., additional, Chabot, F., additional, Selton-Suty, C., additional, Krastev, B., additional, Kinova, E. T. K., additional, Zlatareva, N. I. Z., additional, Goudev, A. R. G., additional, Teske, A. J., additional, De Boeck, B. W., additional, Mohames Hoesein, F. A., additional, Van Driel, V., additional, Loh, P., additional, Cramer, M. J., additional, Doevendans, P. A., additional, Dillenburg, F., additional, Abd El Salam, K. M., additional, Ho, E. M. M., additional, Hall, M., additional, Hemeryck, L., additional, Bennett, K., additional, Scott, K., additional, King, G., additional, Murphy, R. T., additional, Mahmud, A., additional, Brown, A. S., additional, Dalen, H., additional, Thorstensen, A., additional, Romundstad, P. R., additional, Aase, S. A., additional, Stoylen, A., additional, Vatten, L., additional, Bochenek, T., additional, Wita, K., additional, Tabor, Z., additional, Doruchowska, A., additional, Lelek, M., additional, Trusz-Gluza, M., additional, Hamodraka, E., additional, Paraskevaidis, I., additional, Karamanou, A., additional, Michalakeas, C., additional, Vrettou, H., additional, Kapsali, E., additional, Tsiapras, D., additional, Lekakis, I., additional, Anastasiou-Nana, M., additional, Kremastinos, D., additional, Sirugo, L., additional, Bottari, V. E., additional, Licciardi, S., additional, Blundo, A., additional, Atanasio, A., additional, Monte, I. P., additional, Park, C. S., additional, Kim, J. H., additional, Cho, J. S., additional, Kim, M. J., additional, Cho, E. J., additional, Ihm, S. H., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, K. S., additional, Fontana, A., additional, Taravella, L., additional, Zambon, A., additional, Trocino, G., additional, Giannattasio, C., additional, Kalinin, A., additional, Alekhin, M., additional, Bahs, G., additional, Lejnieks, A., additional, Kalvelis, A., additional, Kalnins, A., additional, Shipachovs, P., additional, Zakharova, E., additional, Blumentale, G., additional, Trukshina, M., additional, Biering-Sorensen, T., additional, Mogelvang, R., additional, Haahr-Pedersen, S., additional, Schnohr, P., additional, Sogaard, P., additional, Skov Jensen, J., additional, Gargani, L., additional, Agoston, G., additional, Capati, E., additional, Badano, L., additional, Moreo, A., additional, Costantino, M. F., additional, Caputo, M. L., additional, Mondillo, S., additional, Sicari, R., additional, Picano, E., additional, Malev, E. G., additional, Timofeev, E. V., additional, Reeva, S. V., additional, Zemtsovsky, E. V., additional, Piazza, R., additional, Enache, R., additional, Roman-Pognuz, A., additional, Leiballi, E., additional, Pecoraro, R., additional, Sadeghian, H., additional, Lotfi_Tokaldany, M., additional, Rezvanfard, M., additional, Kasemisaeid, A., additional, Majidi, S., additional, Montazeri, M., additional, Saber-Ayad, M., additional, Nassar, Y. S., additional, Farhan, A., additional, Moussa, A., additional, El-Sherif, A., additional, Cooper, R. M., additional, Somauroo, J. D., additional, Shave, R. E., additional, Williams, K. L., additional, Forster, J., additional, George, C., additional, Bett, T., additional, Gaze, D. C., additional, George, K. P., additional, Mansencal, N., additional, Dupland, A., additional, Caille, V., additional, Perrot, S., additional, Bouferrache, K., additional, Vieillard-Baron, A., additional, Jouffroy, R., additional, Cioroiu, S. G., additional, Alexe, O. S., additional, Bobescu, E., additional, Rus, H., additional, Schiano Lomoriello, V., additional, Esposito, R., additional, Santoro, A., additional, Raia, R., additional, Farina, F., additional, Ippolito, R., additional, Galderisi, M., additional, Aburawi, E. H., additional, Malcus, P., additional, Thuring, A., additional, Maxedius, A., additional, Pesonen, E., additional, Nair, S. V., additional, Joyce, E., additional, Lee, L., additional, Shrimpton, J., additional, Newman, E., additional, James, P. R., additional, Jurcut, C., additional, Caraiola, S., additional, Jurcut, R. O., additional, Giusca, S., additional, Nitescu, D., additional, Amzulescu, M. S., additional, Copaci, I., additional, Tanasescu, C., additional, Silva Marques, J., additional, Silva, D., additional, Ferreira, F., additional, Ferreira, P. C., additional, Almeida, A. G., additional, Martim Martins, J., additional, Lopes, M. 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H., additional, Larsson, M., additional, Kremer, F., additional, Kouznetsova, T., additional, Bjallmark, A., additional, Lind, B., additional, Brodin, L.-A., additional, D'hooge, J., additional, Caputo, M., additional, Antonelli, G., additional, Lisi, M., additional, Giacomin, E., additional, Moustafa, S., additional, Alharthi, M., additional, Deng, Y., additional, Chandrasekaran, K., additional, Mookadam, F., additional, Hayashi, S. Y., additional, Nascimento, M. M., additional, Lindholm, B., additional, Seeberger, A., additional, Nowak, J., additional, Riella, M. C., additional, Brodin, L. A., additional, Theodosis, A., additional, Fousteris, E., additional, Tsiaousis, G., additional, Krommydas, A., additional, Margetis, P., additional, Katidis, Z., additional, Beldekos, D., additional, Argirakis, S., additional, Melidonis, A., additional, Foussas, S., additional, Khaleva, O., additional, Onyshchenko, O., additional, Lukaschuk, E., additional, Sherwi, N., additional, Nikitin, N., additional, Cleland, J. G. F., additional, Risum, N., additional, Jons, C., additional, Olsen, N. T., additional, Kronborg, M. B., additional, Jensen, M. T., additional, Fritz-Hansen, T., additional, Bruun, N. E., additional, Hojgaard, M. V., additional, Petrini, J., additional, Yousry, M., additional, Rickenlund, A., additional, Liska, J., additional, Franco-Cereceda, A., additional, Hamsten, A., additional, Eriksson, P., additional, Caidahl, K., additional, Eriksson, M. J., additional, Elmstedt, N., additional, Ferm-Widlund, K., additional, Westgren, M., additional, Szymczyk, E., additional, Kasprzak, J. D., additional, Wozniakowski, B., additional, Rotkiewicz, A., additional, Szymczyk, K., additional, Stefanczyk, L., additional, Michalski, B., additional, Lipiec, P., additional, Ring, L., additional, Eller, T., additional, Deegan, P., additional, Rusk, R., additional, Urbano Moral, J. A., additional, Arias, J. A., additional, Kuvin, J. T., additional, Patel, A. R., additional, Pandian, N. G., additional, Bellsham-Revell, H., additional, Bell, A. J., additional, Miller, O., additional, Greil, G. F., additional, Simpson, J., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Severino, S., additional, Nunziata, L., additional, Roselli, T., additional, Dussault, C., additional, Lafitte, S., additional, Habib, G., additional, Reant, P., additional, Derumeaux, G., additional, Thibault, H., additional, Kaladaridis, A., additional, Agrios, I. A., additional, Pamboucas, C. P., additional, Mesogitis, S. M., additional, Vasiladiotis, N. V., additional, Bramos, D. B., additional, Toumanidis, S. T. T., additional, Martiniello, A. R., additional, Santangelo, G., additional, Pedrizzetti, G., additional, Tonti, G., additional, Cioppa, C., additional, Cavallaro, M., additional, Calvi, V., additional, and Chianese, R., additional

Published
2010
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27. Prearrest administration of low-molecular-weight heparin in porcine cardiac arrest: hemodynamic effects and resuscitability.

Author

Pytte M, Bendz B, Kramer-Johansen J, Eriksen M, Strømme TA, Eilevstjønn J, Brosstad F, and Sunde K

Abstract

OBJECTIVE: Both animal and human studies demonstrate activation of coagulation during cardiac arrest. Prearrest anticoagulation is used routinely in many experimental studies. We studied the hemodynamic effects of prearrest anticoagulation with a low-molecular-weight heparin suitable for clinical use during cardiopulmonary resuscitation in pigs. DESIGN: Randomized and blinded experimental animal study. SETTING: University hospital-affiliated research laboratory. SUBJECTS: Sixteen female domestic pigs. INTERVENTIONS: Three minutes before electrically induced ventricular fibrillation, enoxaparin 1 mg/kg or physiologic saline was blinded and administered intravenously. After 10 mins of untreated ventricular fibrillation, advanced cardiac life support was initiated with continuous mechanical chest compressions and interposed manual ventilation with 100% oxygen. Epinephrine was administered after 2 mins of advanced cardiac life support followed by attempted defibrillation 1 min thereafter. Advanced cardiac life support was continued for 10 mins following international guidelines. Electrocardiogram was recorded continuously and ventricular fibrillation waveform was analyzed (median slope). Animals with return of spontaneous circulation were observed for ten more minutes. Blood specimens were drawn for analysis of coagulation activation (thrombin-antithrombin complex) and drug effect (anti-factor Xa activity). MEASUREMENTS AND MAIN RESULTS: Six of eight (75%) pigs in each group achieved return of spontaneous circulation. Thrombin-antithrombin complex levels were significantly lower in pigs that received enoxaparin. There was no significant difference either in measured hemodynamics between the groups during advanced cardiac life support and after return of spontaneous circulation or in median slope values during ventricular fibrillation. Epinephrine caused a significant decrease in femoral and increase in cerebral cortical blood flow with no difference between the groups. CONCLUSIONS: Prearrest anticoagulation with enoxaparin did not influence either hemodynamics during advanced cardiac life support and after return of spontaneous circulation or the frequency of return of spontaneous circulation in porcine cardiac arrest. [ABSTRACT FROM AUTHOR]

Published
2008
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32. In patients ≥ 80 y with NSTEMI or unstable angina, an invasive strategy reduced CV outcomes.

Author

Pakala, Aneesh V., Mathew, Sunil T., and Bendz, B.

Subjects
ANGINA pectoris, MYOCARDIAL infarction, RANDOMIZED controlled trials, CARDIAC surgery, FOLLOW-up studies (Medicine), CORONARY artery bypass, PERCUTANEOUS coronary intervention, REVASCULARIZATION (Surgery), STATISTICAL sampling
Abstract

Question In patients ≥ 80 years of age with non-ST-elevation myocardial infarction (NSTEMI) or unstable angina, what is the effect of an invasive compared with a conservative strategy on cardiovascular outcomes? Methods Design Randomized controlled trial (After Eighty study). ClinicalTrials.gov NCT01255540. Allocation Concealed.* Blinding Unblinded*. Follow-up period Median 1.5 years. Setting 16 academic and teaching hospitals in the South-East Health Region of Norway. Patients 457 patients ≥ 80 years of age (mean age 85 y, 51% women) who had NSTEMI or unstable angina, with or without ST-segment depression on electrocardiogram, and normal or increased troponin T or I levels. Exclusion criteria included clinical instability with ongoing chest pain or other ischemic symptoms, cardiogenic shock, ongoing bleeding, life expectancy < 12 months due to serious comorbidity, or substantial mental disorder. Intervention Invasive strategy comprising early coronary angiography with immediate assessment for percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or optimum medical treatment (OMT) (n = 229), or conservative strategy comprising OMT only (n = 228). Outcomes Primary outcome was a composite of myocardial infarction, need for urgent revascularization, stroke, or death. Secondary outcomes included components of the primary outcome. Patient follow-up 100% (intention-to-treat analysis). Main results The main results are in the Table. Conclusion In patients ≥ 80 years of age with non-ST-elevation myocardial infarction or unstable angina, an invasive strategy reduced a cardiovascular composite outcome compared with a conservative strategy. [ABSTRACT FROM AUTHOR]

Published
2016
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34. Reperfusion therapy and strategies in acute myocardial infarction.

Author

Bendz, Bjørn, Mangschau, Arild, Bendz, B, and Mangschau, A

Subjects
MYOCARDIAL infarction treatment, REPERFUSION, MYOCARDIAL reperfusion, PROGNOSIS
Abstract

Examines reperfusion therapy and strategies in acute myocardial infarction. Choice of primary angioplasty in well-equipped and experienced centers; Increase in the use of prehospital diagnosis and thrombolysis or anti-platelet therapy; Establishment of early and satisfactory reperfusion by pharmacological agents.

Published
2000
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35. Poster session 6: Saturday 6 December 2014, 08:30-12:30 * Location: Poster area

Author

Goirigolzarri Artaza, J, Gallego Delgado, M, Jaimes Castellanos, CP, Cavero Gibanel, MA, Pastrana Ledesma, MA, Alonso Pulpon, LA, Gonzalez Mirelis, J, Al Ansi, R Z, Sokolovic, S, Cerin, G, Szychta, W, Popa, B A, Botezatu, D, Benea, D, Manganiello, S, Corlan, A, Jabour, A, Igual Munoz, B, Osaca Asensi, JOA, Andres La Huerta, AALH, Maceira Gonzalez, AMG, Estornell Erill, JEE, Cano Perez, OCP, Sancho-Tello, MJSTDC, Alonso Fernandez, PAF, Sepulveda Sanchez, PSS, Montero Argudo, AMA, Palombo, C, Morizzo, C, Baluci, M, Kozakova, M, Panajotu, A, Karady, J, Szeplaki, G, Horvath, T, Tarnoki, DL, Jermendy, AL, Geller, L, Merkely, B, Maurovich-Horvat, P, Group, MTA-SE "Lendület" Cardiovascular Imaging Research, Moustafa, S, Mookadam, F, Youssef, M, Zuhairy, H, Connelly, M, Prieur, T, Alvarez, N, Ashikhmin, Y, Drapkina, O, Boutsikou, M, Demerouti, E, Leontiadis, E, Petrou, E, Karatasakis, G, Kozakova, M, Morizzo, C, Bianchi, V, Marchi, B, Federico, G, Palombo, C, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Goto, M, Uejima, T, Itatani, K, Pedrizzetti, G, Mada, RO, Daraban, AM, Duchenne, J, Voigt, JU, Chiu, D Y Y, Green, D, Johnstone, L, Sinha, S, Kalra, PA, Abidin, N, Group, Salford Vascular Research, Sikora-Frac, M, Zaborska, B, Maciejewski, P, Bednarz, B, Budaj, A, Nemes, A, Sasi, V, Gavaller, H, Kalapos, A, Domsik, P, Katona, A, Szucsborus, T, Ungi, T, Forster, T, Ungi, I, Pluchinotta, FR, Arcidiacono, C, Saracino, A, Carminati, M, Bussadori, C, Dahlslett, T, Karlsen, S, Grenne, B, Sjoli, B, Bendz, B, Skulstad, H, Smiseth, OA, Edvardsen, T, Brunvand, H, Vereckei, A, Szelenyi, ZS, Szenasi, G, Santoro, C, Galderisi, M, Niglio, T, Santoro, M, Stabile, E, Rapacciuolo, A, Spinelli, L, De Simone, G, Esposito, G, Trimarco, B, Hubert, S, Jacquier, A, Fromonot, J, Resseguier, C, Tessier, A, Guieu, R, Renard, S, Haentjiens, J, Lavoute, C, Habib, G, Menting, M E, Koopman, LP, Mcghie, 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Garcia-Campos, A, Diaz, E, Martin, M, Rodriguez-Suarez, ML, Leon, V, Fidalgo, A, Moris, C, De La Hera, JM, Kylmala, M M, Rosengard-Barlund, M, Groop, P H, Lommi, J, Bruin De- Bon, HACM, Bilt Van Der, IA, Wilde, AA, Brink Van Den, RBA, Teske, AJ, Rinkel, GJ, Bouma, BJ, Teixeira, R, Monteiro, R, Garcia, J, Silva, A, Graca, M, Baptista, R, Ribeiro, M, Cardim, N, Goncalves, L, Duszanska, A, Skoczylas, I, Kukulski, T, Polonski, L, Kalarus, Z, Choi, J-H, Park, JS, Ahn, JH, Lee, JW, Ryu, SK, Ahn, J, Kim, DH, Lee, HO, Przewlocka-Kosmala, M, Mlynarczyk, J, Rojek, A, Mysiak, A, Kosmala, W, Pellissier, A, Larochelle, E, Krsticevic, L, Baron, E, Le, V, Roy, A, Deragon, A, Cote, M, Garcia, D, Tournoux, F, Yiangou, K, Azina, C, Yiangou, A, Zitti, M, Ioannides, M, Ricci, F, Dipace, G, Aquilani, R, Radico, F, Cicchitti, V, Bianco, F, Miniero, E, Petrini, F, De Caterina, R, Gallina, S, Jardim Prista Monteiro, R, Teixeira, R, Garcia, J, Baptista, R, Ribeiro, M, Cardim, N, Goncalves, L, Chung, H, Kim, JY, Joung, B, Uhm, JS, Pak, HN, Lee, MH, Lee, KY, Ragab, AM, Abdelwahab, AMIR, Yazeed, YASER, El Naggar, WAEL, Spahiu, K, Spahiu, E, Doko, A, Liesting, C, Brugts, JJ, Kofflard, MJM, Kitzen, JJEM, Boersma, E, Levin, M-D, Coppola, C, Piscopo, G, Rea, D, Maurea, C, Caronna, A, Capasso, I, Maurea, N, Azevedo, O, Tadeu, I, Lourenco, M, Portugues, J, Pereira, V, Lourenco, A, Nesukay, E, Kovalenko, V, Cherniuk, S, Danylenko, O, Muhammedov, MB, Ahmedova, DM, Hojakuliyev, BG, Atayeva, D, Nemes, A, Domsik, P, Kalapos, A, Lengyel, C, Varkonyi, TT, Orosz, A, Forster, T, Castro, M, Abecasis, J, Dores, H, Madeira, S, Horta, E, Ribeiras, R, Canada, M, Andrade, MJ, Mendes, M, Morosin, M, Piazza, R, Leonelli, V, Leiballi, E, Pecoraro, R, Cinello, M, Dell' Angela, L, Cassin, M, Sinagra, G, Nicolosi, GL, Wierzbowska-Drabik, K, Hamala, P, Kasprzak, JD, O'driscoll, J, Rossato, C, Gargallo-Fernandez, P, Araco, M, Sharma, S, Sharma, R, Jakus, N, Baricevic, Z, Ljubas Macek, J, Skoric, B, Skorak, I, Velagic, V, Separovic Hanzevacki, J, Milicic, D, Cikes, M, Deljanin Ilic, M, Ilic, S, Kocic, G, Pavlovic, R, Stoickov, V, Ilic, V, Nikolic, LJ, Generati, G, Bandera, F, Pellegrino, M, Alfonzetti, E, Labate, V, Guazzi, M, Labate, V, Bandera, F, Generati, G, Pellegrino, M, Donghi, V, Alfonzetti, E, Guazzi, M, Zakarkaite, D, Kramena, R, Aidietiene, S, Janusauskas, V, Rucinskas, K, Samalavicius, R, Norkiene, I, Speciali, G, Aidietis, A, Kemaloglu Oz, T, Ozpamuk Karadeniz, F, Akyuz, S, Unal Dayi, S, Esen Zencirci, A, Atasoy, I, Osken, A, Eren, M, Fazendas, P R, Caldeira, D, Stuart, B, Cruz, I, Rocha Lopes, L, Almeida, A R, Sousa, P, Joao, I, Cotrim, C, Pereira, H, Fazendas, P R, Caldeira, D, Stuart, B, Cruz, I, Rocha Lopes, L, Almeida, A R, Joao, I, Cotrim, C, Pereira, H, Sinem Cakal, SC, Elif Eroglu, EE, Baydar, O, Beytullah Cakal, BC, Mehmet Vefik Yazicioglu, MVY, Mustafa Bulut, MB, Cihan Dundar, CD, Kursat Tigen, KT, Birol Ozkan, BO, Ali Metin Esen, A, Yagasaki, H, Kawasaki, M, Tanaka, R, Minatoguchi, S, Houle, H, Warita, S, Ono, K, Noda, T, Watanabe, S, Minatoguchi, S, Cho, E J, Park, S J, Lim, H J, Chang, S A, Lee, S C, Park, S W, Cho, E J, Park, S J, Lim, H J, Chang, S A, Lee, S C, Park, S W, Mornos, C, Cozma, D, Ionac, A, Mornos, A, Popescu, I, Ionescu, G, Pescariu, S, Melzer, L, Faeh-Gunz, A, Seifert, B, Attenhofer Jost, C H, Storve, S, Haugen, BO, Dalen, H, Grue, JF, Samstad, S, Torp, H, Ferrarotti, L, Maggi, E, Piccinino, C, Sola, D, Pastore, F, Marino, PN, Ranjbar, S, Karvandi, M, Hassantash, SA, Karvandi, M, Ranjbar, S, Tierens, S, Remory, I, Bala, G, Gillis, K, Hernot, S, Droogmans, S, Cosyns, B, Lahoutte, T, Tran, N, Poelaert, J, Al-Mallah, M, Alsaileek, A, Nour, K, Celeng, CS, Horvath, T, Kolossvary, M, Karolyi, M, Panajotu, A, Kitslaar, P, Merkely, B, Maurovich Horvat, P, Group, MTA-SE "Lendület" Cardiovascular Imaging Research, Aguiar Rosa, S, Ramos, R, Marques, H, Portugal, G, Pereira Da Silva, T, Rio, P, Afonso Nogueira, M, Viveiros Monteiro, A, Figueiredo, L, and Cruz Ferreira, R

Abstract

Introduction: The increase of left auricular volume (LAV) is a robust cardiovascular event predictor. Despite that echochardiography is more often used, cardiac MRI is considered more accurate. Our objetives are to validate "fast" LAV measures by MRI vs the considered gold standard (GS) and to compare Echo and MRI in a wide spectrum of patients. Methods: In a non-selected popullation with MRI study previously realized, we measured LAV by biplane method (BPMR) and by area-length in 4 chamber view (ALMR) and compared them with biplane (BPe) and discs method (MDDe) in 4 chamber view in echo. To validate MRI measurements, we measured LAV in short axis slices (Simpson Method, SM) in a group of patients and considered it the GS. Results: 186 patients were included (mean age 51 ± 17 age; 123 male; 14 in AF) with clinical indication of cardiac MRI (Philips 1,5 T). In 24 patients SM was calculated. 29% of cardiac MRI were considered normal. Mean underlying pathologies were myocardiopathy (27%), Ischemic myocardiopathy (17%), myopericarditis (10%), prior to AF ablation (4%), valvular disease (6%) and miscellaneous (7%). Excellent correlation was obtained between "fast" MRI measurements and SM in MRI (SM vs BPMR interclass correlation coefficient ICC=0.965 and SM vs ALMR, ICC=0.958; P<0.05) with low interobserver variability (ICC=0.983 for SM; ICC=0.949 for BPMR; ICC=0.931 for ALMR). "Fast" measurements by MRI showed stadistical correlation between them (CCI=0.910) (Figure). Correlation between Echo and MRI measures was only moderate. (BPRM vs BPe CCI=0,469 mean difference -30 ml; ALMR vs MDDe ICC=0,456 mean difference -24 mL). Conclusions: ‘fast’ LAV measures by MRI are comparable with the MRI GS and also between them. Echo values seem to underestimate compared to MRI, so its use may not be suitable.

Published
2014
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36. Routine Invasive Versus Conservative Management of Non-ST Elevation Acute Coronary Syndromes in Patients With Previous Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomised Clinical Trials.

Author

Kelham, M., Vyas, R., Rameseshan, R., Rathod, K., de Winter, R.J., de Winter, R.W., Bendz, B., Thiele, H., Hirlekar, G., Morici, N., Myat, A., Michalis, L., Sanchis, J., Kunadian, V., Berry, C., Mathur, A., and Jones, D.

Subjects
*CORONARY artery bypass, *ACUTE coronary syndrome, *CLINICAL trials, *MYOCARDIAL infarction, *MUCOCUTANEOUS lymph node syndrome
Published
2024
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37. Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease.

Author

Bønaa, K. H., Mannsverk, J., Wiseth, R., Aaberge, L., Myreng, Y., Nygård, O., Nilsen, D. W., Kløw, N. -E., Uchto, M., Trovik, T., Bendz, B., Stavnes, S., Bjørnerheim, R., Larsen, A. -I., Slette, M., Steigen, T., Jakobsen, O. J., Bleie, Ø., Fossum, E., and Hanssen, T. A.

Subjects
*CORONARY heart disease treatment, *DRUG-eluting stents, *PERCUTANEOUS coronary intervention, *MYOCARDIAL infarction risk factors, *QUALITY of life, *MYOCARDIAL revascularization, *THROMBOSIS, *CORONARY disease, *LONGITUDINAL method, *MYOCARDIAL infarction, *REOPERATION, *RESEARCH funding, *SURGICAL stents, *TRANSLUMINAL angioplasty, *RAPAMYCIN, *RANDOMIZED controlled trials, *KAPLAN-Meier estimator
Abstract

Background: Limited data are available on the long-term effects of contemporary drug-eluting stents versus contemporary bare-metal stents on rates of death, myocardial infarction, repeat revascularization, and stent thrombosis and on quality of life.Methods: We randomly assigned 9013 patients who had stable or unstable coronary artery disease to undergo percutaneous coronary intervention (PCI) with the implantation of either contemporary drug-eluting stents or bare-metal stents. In the group receiving drug-eluting stents, 96% of the patients received either everolimus- or zotarolimus-eluting stents. The primary outcome was a composite of death from any cause and nonfatal spontaneous myocardial infarction after a median of 5 years of follow-up. Secondary outcomes included repeat revascularization, stent thrombosis, and quality of life.Results: At 6 years, the rates of the primary outcome were 16.6% in the group receiving drug-eluting stents and 17.1% in the group receiving bare-metal stents (hazard ratio, 0.98; 95% confidence interval [CI], 0.88 to 1.09; P=0.66). There were no significant between-group differences in the components of the primary outcome. The 6-year rates of any repeat revascularization were 16.5% in the group receiving drug-eluting stents and 19.8% in the group receiving bare-metal stents (hazard ratio, 0.76; 95% CI, 0.69 to 0.85; P<0.001); the rates of definite stent thrombosis were 0.8% and 1.2%, respectively (P=0.0498). Quality-of-life measures did not differ significantly between the two groups.Conclusions: In patients undergoing PCI, there were no significant differences between those receiving drug-eluting stents and those receiving bare-metal stents in the composite outcome of death from any cause and nonfatal spontaneous myocardial infarction. Rates of repeat revascularization were lower in the group receiving drug-eluting stents. (Funded by the Norwegian Research Council and others; NORSTENT ClinicalTrials.gov number, NCT00811772 .). [ABSTRACT FROM AUTHOR]

Published
2016
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38. Association between acute hypobaric hypoxia and activation of coagulation in human beings.

Author

Bendz, Bjorn, Rostrup, Morten, Sevre, Knut, Andersen, Trine 0, Sandset, Per Morten, Bendz, B, Rostrup, M, Sevre, K, Andersen, T O, and Sandset, P M

Subjects
*BLOOD coagulation, *THROMBOSIS risk factors, *HYPOXEMIA, *AIR travel, *SCIENTIFIC experimentation, *HEALTH, *PHYSIOLOGY
Abstract

The risk of venous thrombosis is thought to be increased by flying. In a study of 20 healthy male volunteers who were suddenly exposed to a hypobaric environment similar to that encountered within aeroplane cabins, markers of activated coagulation transiently Increased by two-fold to eight-fold. We suggest that hypobaric hypoxia, with sedentariness and dehydration, may cause this increased risk of venous thrombosis. [ABSTRACT FROM AUTHOR]

Published
2000
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39. Appropriateness and outcomes of hospitalized patients telemetry monitored for cardiac arrhythmias in accordance with the American Heart Association Practice Standards-A multicenter study.

Author

Holm MS, Fålun N, Pettersen TR, Bendz B, Nilsen RM, Langørgen J, Larsen AI, Sørensen ML, Sandau KE, and Norekvål TM

Subjects
Humans, Male, Female, Aged, Prospective Studies, United States, Norway, American Heart Association, Middle Aged, Hospitalization statistics & numerical data, Practice Guidelines as Topic, Monitoring, Physiologic methods, Monitoring, Physiologic standards, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac therapy, Telemetry methods, Telemetry standards, Telemetry statistics & numerical data
Abstract

Background: To the best of our knowledge, no prospective research studies have compared clinical practice to the American Heart Association (AHA) updated practice standards for in-hospital telemetry monitoring., Objectives: Our aims were therefore (1) to investigate how patients were assigned to telemetry monitoring in accordance with the AHA's updated practice standards, (2) to determine the number and type of arrhythmic events, and (3) to describe subsequent changes in clinical management., Methods: This prospective multicenter study included 1154 patients at three university hospitals in Norway. Data were collected 24/7 over a four-week period, with follow-up measurements from telemetry admission until hospital discharge., Results: Of patients assigned to telemetry, 67 % (n = 767) met practice standards, corresponding to AHA Class I or II. Patients were predominantly men (65 %, n = 748), and the mean age was 65 years (SD ±16). The study included both patients with cardiac and non-cardiac diagnoses from various medical and surgical departments throughout the hospitals. Ninety-one percent of the patients in Class III were monitored based on indications that were reclassified from Class II to Class III (not indicated) in the updated practice standards (patients admitted with chest pain or post-percutaneous coronary intervention (PCI) without complications). Overall, arrhythmic events occurred in 37 % (n = 424) of patients, and they occurred in all classes. Eighteen percent (n = 59) of arrhythmic events occurred in Class III. Of all arrhythmias, 3 % (n = 14) were life threatening, and all of them occurring within Class I. Telemetry monitoring led to changes in clinical management in 22 % (n = 257) of patients due to clinical alarms, of which 71 % (n = 182) were related to medication management., Conclusions: Most patients were appropriately monitored according to the AHA practice standards, meeting Class I and II. Arrhythmias occurred in all classes, but life-threatening arrhythmias only occurred in patients in Class I. However, a daily re-assessment of each patient's telemetry indication is warranted., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2024
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40. HoloPatch: improving intracardiac patch fit through holographically modelled templates.

Author

Lippert M, d' Albenzio G, Suther KR, Dumont KA, Palomar R, Odland HH, Elle OJ, Bendz B, and Brun H

Abstract

Aims: Structural heart defects, including congenital ventricular septal defect closure or intracardiac rerouting, frequently require surgical reconstruction using hand-cut patch materials. Digitally modelled patch templates may improve patch fit and reduce outflow tract obstruction, residual defect risk, and conduction system damage. In this study, we benchmarked mixed-reality and a desktop application against a digitalized model of a real implanted patch., Methods and Results: Ten patients scheduled for the repair of various defects consented to prospective inclusion in the study. After surgery, a digital model of the implanted patch was created from the residual material. Five clinical experts created 10 digital patches, 1 per patient, both in mixed-reality and desktop application, for comparison with the reference measurements, including the digitalized model of the real patch used during the surgery. Subjective residual shunt risk prediction was performed using both modalities. Digital patches created in mixed-reality closely matched the surgical material, whereas those created using desktop applications were significantly smaller. Different evaluators showed varying preferences for the application of the residual shunt risk and area., Conclusion: Digitally created patches can assist surgeons in preoperatively sizing of patch implants, potentially reducing post-operative complications., Competing Interests: Conflict of interest: H.B., O.J.E., and R.P. are co-inventors of the technology licenced by HoloCare AS and hold shares in the company indirectly through Inven2 AS. All other authors declare no competing financial or non-financial interests., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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41. 'When age is not a barrier': an explorative study of nonagenarian patients' experiences of undergoing percutaneous coronary intervention.

Author

Instenes I, Fridlund B, Borregaard B, Larsen AI, Allore H, Bendz B, Deaton C, Rotevatn S, Fålun N, and Norekvål TM

Subjects
Humans, Female, Male, Aged, 80 and over, Qualitative Research, Age Factors, Percutaneous Coronary Intervention psychology
Abstract

Aims: The recent rise in the number of nonagenarians (age ≥ 90 years) undergoing percutaneous coronary intervention (PCI) has revealed gaps in research, in particular on patients' experiences. Therefore, the aim of the study was to explore and describe nonagenarians' internal resources and their experiences of the in-hospital pathway., Methods and Results: Nineteen nonagenarian patients (women n = 9), mean age 91 years, 9 acutely, and 10 electively treated, were consecutively enrolled from a tertiary university hospital from June 2021 to February 2023. In-depth interviews were conducted during hospitalization, audiotaped and transcribed. The interviews were analysed using qualitative content analysis. Three sub-themes emerged from the nonagenarians' experiences with the PCI treatment trajectory: (i) Taking lifelong responsibility for own physical and mental health describes a population striving to live a healthy life and to stay independent. Physical and mental activities including healthy food choices had been an integral aspect of their lives from early childhood. (ii) Individual internal resources influenced the PCI pathway describes how their internal resources were used, from actively engaging in the decision-making process to withstanding discomfort during the PCI procedure. (iii) The post-PCI pathway was multifaceted describes a short stay at the cardiac ward with individual post-procedural experiences, close monitoring, and preparation for discharge including cardiac rehabilitation., Conclusion: Nonagenarians undergoing PCI demonstrated a personal incentive to stay healthy and independent. Their internal resources of independence, stoicism, and resilience were used during their in-hospital stay contributing to a successful PCI procedure. Individual cardiac rehabilitation strategies were highlighted after discharge from hospital., Competing Interests: Conflict of interest: The authors declare that there is no conflict of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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42. Non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting: a meta-analysis of invasive vs. conservative management.

Author

Kelham M, Vyas R, Ramaseshan R, Rathod K, de Winter RJ, de Winter RW, Bendz B, Thiele H, Hirlekar G, Morici N, Myat A, Michalis LK, Sanchis J, Kunadian V, Berry C, Mathur A, and Jones DA

Subjects
Humans, Non-ST Elevated Myocardial Infarction surgery, Non-ST Elevated Myocardial Infarction therapy, Non-ST Elevated Myocardial Infarction mortality, Percutaneous Coronary Intervention methods, Acute Coronary Syndrome therapy, Acute Coronary Syndrome surgery, Conservative Treatment methods, Coronary Artery Bypass, Randomized Controlled Trials as Topic
Abstract

Background and Aims: A routine invasive strategy is recommended in the management of higher risk patients with non-ST-elevation acute coronary syndromes (NSTE-ACSs). However, patients with previous coronary artery bypass graft (CABG) surgery were excluded from key trials that informed these guidelines. Thus, the benefit of a routine invasive strategy is less certain in this specific subgroup., Methods: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted. A comprehensive search was performed of PubMed, EMBASE, Cochrane, and ClinicalTrials.gov. Eligible studies were RCTs of routine invasive vs. a conservative or selective invasive strategy in patients presenting with NSTE-ACS that included patients with previous CABG. Summary data were collected from the authors of each trial if not previously published. Outcomes assessed were all-cause mortality, cardiac mortality, myocardial infarction, and cardiac-related hospitalization. Using a random-effects model, risk ratios (RRs) with 95% confidence intervals (CIs) were calculated., Results: Summary data were obtained from 11 RCTs, including previously unpublished subgroup outcomes of nine trials, comprising 897 patients with previous CABG (477 routine invasive, 420 conservative/selective invasive) followed up for a weighted mean of 2.0 (range 0.5-10) years. A routine invasive strategy did not reduce all-cause mortality (RR 1.12, 95% CI 0.97-1.29), cardiac mortality (RR 1.05, 95% CI 0.70-1.58), myocardial infarction (RR 0.90, 95% CI 0.65-1.23), or cardiac-related hospitalization (RR 1.05, 95% CI 0.78-1.40)., Conclusions: This is the first meta-analysis assessing the effect of a routine invasive strategy in patients with prior CABG who present with NSTE-ACS. The results confirm the under-representation of this patient group in RCTs of invasive management in NSTE-ACS and suggest that there is no benefit to a routine invasive strategy compared to a conservative approach with regard to major adverse cardiac events. These findings should be validated in an adequately powered RCT., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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43. Invasive vs. conservative management of older patients with non-ST-elevation acute coronary syndrome: individual patient data meta-analysis.

Author

Kotanidis CP, Mills GB, Bendz B, Berg ES, Hildick-Smith D, Hirlekar G, Milasinovic D, Morici N, Myat A, Tegn N, Sanchis J, Savonitto S, De Servi S, Fox KAA, Pocock S, and Kunadian V

Subjects
Humans, Aged, Randomized Controlled Trials as Topic, Myocardial Revascularization statistics & numerical data, Coronary Angiography, Non-ST Elevated Myocardial Infarction therapy, Non-ST Elevated Myocardial Infarction mortality, Female, Conservative Treatment methods, Acute Coronary Syndrome therapy, Acute Coronary Syndrome mortality, Percutaneous Coronary Intervention
Abstract

Background and Aims: Older patients with non-ST-elevation acute coronary syndrome (NSTEACS) are less likely to receive guideline-recommended care including coronary angiography and revascularization. Evidence-based recommendations regarding interventional management strategies in this patient cohort are scarce. This meta-analysis aimed to assess the impact of routine invasive vs. conservative management of NSTEACS by using individual patient data (IPD) from all available randomized controlled trials (RCTs) including older patients., Methods: MEDLINE, Web of Science and Scopus were searched between 1 January 2010 and 11 September 2023. RCTs investigating routine invasive and conservative strategies in persons >70 years old with NSTEACS were included. Observational studies or trials involving populations outside the target range were excluded. The primary endpoint was a composite of all-cause mortality and myocardial infarction (MI) at 1 year. One-stage IPD meta-analyses were adopted by use of random-effects and fixed-effect Cox models. This meta-analysis is registered with PROSPERO (CRD42023379819)., Results: Six eligible studies were identified including 1479 participants. The primary endpoint occurred in 181 of 736 (24.5%) participants in the invasive management group compared with 215 of 743 (28.9%) participants in the conservative management group with a hazard ratio (HR) from random-effects model of 0.87 (95% CI 0.63-1.22; P = .43). The hazard for MI at 1 year was significantly lower in the invasive group compared with the conservative group (HR from random-effects model 0.62, 95% CI 0.44-0.87; P = .006). Similar results were seen for urgent revascularization (HR from random-effects model 0.41, 95% CI 0.18-0.95; P = .037). There was no significant difference in mortality., Conclusions: No evidence was found that routine invasive treatment for NSTEACS in older patients reduces the risk of a composite of all-cause mortality and MI within 1 year compared with conservative management. However, there is convincing evidence that invasive treatment significantly lowers the risk of repeat MI or urgent revascularisation. Further evidence is needed from ongoing larger clinical trials., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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44. The patient experience of in-hospital telemetry monitoring: a qualitative analysis.

Author

Holm MS, Fålun N, Bendz B, Fridlund B, Langørgen J, Pettersen TR, Sandau KE, and Norekvål TM

Subjects
Male, Humans, Female, Adult, Middle Aged, Aged, Aged, 80 and over, Patients, Hospitals, University, Patient Outcome Assessment, Telemetry methods, Arrhythmias, Cardiac diagnosis
Abstract

Aims: In-hospital telemetry monitoring has been an integrated part of arrhythmia monitoring for decades. A substantial proportion of patients require arrhythmia monitoring during stays in non-intensive care units. However, studies exploring patients' experiences of telemetry monitoring are scarce. Therefore, the aim was to explore and describe patients' experiences of in-hospital telemetry monitoring in a non-intensive care setting., Methods and Results: Twenty face-to-face, semi-structured interviews were conducted. Interviews were conducted before discharge at two university hospitals in Norway. The patients were purposively sampled, resulting in a well-balanced population comprising 11 men and nine women, mean age 62 years (range 25-83). Average monitoring time was 9 days (range 3-14). Data were audiotaped, transcribed verbatim, and coded using NVivo software. Qualitative content analysis using an inductive approach was performed. Patients expressed a need for individualized information during telemetry monitoring. Their feelings of safety were related to responses from nurses from the central monitoring station when alarms from the telemetry were triggered. Despite perceived physical restrictions and psychological limitations associated with telemetry monitoring, they found monitoring to be beneficial because it facilitated the diagnosis of arrhythmia. Moreover, they expressed a need for improvements in wearable monitoring equipment. Patients expressed ambivalent feelings about discontinuing the telemetry and their readiness for discharge., Conclusion: Patients need individualized information about the results of their telemetry monitoring in order to better understand the arrhythmia management and to increase their experience of safety after discharge. The limitations patients experienced should be taken into consideration in further upgrades of telemetry monitoring equipment., Competing Interests: Conflict of interest: The authors declare that there is no conflict of interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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45. Discharge Information About Adverse Drug Reactions Indicates Lower Self-Reported Adverse Drug Reactions and Fewer Concerns in Patients After Percutaneous Coronary Intervention.

Author

Pettersen TR, Schjøtt J, Allore H, Bendz B, Borregaard B, Fridlund B, Hadjistavropoulos HD, Larsen AI, Nordrehaug JE, Rasmussen TB, Rotevatn S, Valaker I, Wentzel-Larsen T, and Norekvål TM

Subjects
Humans, Female, Male, Cohort Studies, Patient Discharge, Prospective Studies, Self Report, Percutaneous Coronary Intervention adverse effects, Drug-Related Side Effects and Adverse Reactions epidemiology, Drug-Related Side Effects and Adverse Reactions etiology
Abstract

Aim: There are discrepancies between the information patients desire about adverse drug reactions (ADRs) and the information they receive from healthcare providers; this is an impediment to shared decision-making. This study aimed to establish whether patients received information about ADRs resulting from prescribed pharmacotherapy, before hospital discharge, after percutaneous coronary intervention (PCI) and to determine whether receiving information about ADRs was associated with incidence of self-reported ADRs or concerns related to prescribed pharmacotherapy., Methods: CONCARD PCI , a prospective multicentre cohort study including 3,417 consecutive patients after PCI, was conducted at seven high-volume referral PCI centres in two Nordic countries. Clinical data were collected from patients' medical records and national quality registries. Patient-reported outcome measures were registered 2 months (T1), 6 months (T2), and 12 months (T3) after discharge. Covariate-adjusted logistic regression yielded adjusted odds ratios (aORs) with 95% confidence intervals (CIs)., Results: At discharge, 38% of participants had been informed about potential ADRs. For these patients, the incidence of self-reported ADRs was significantly lower at T1 (aOR 0.61, 95% CI 0.50-0.74; p<0.001), T2 (aOR 0.60, 95% CI 0.49-0.74; p<0.001), and T3 (aOR 0.57, 95% CI 0.46-0.71; p<0.001). Those who were not informed reported higher levels of concern about prescribed pharmacotherapy at all measuring points (p<0.001 for all comparisons). Those living alone (aOR 0.73, 95% CI 0.57-0.92; p=0.008), who were female (aOR 0.57, 95% CI 0.44-0.72; p<0.001), and with three or more versus no comorbidities (aOR 0.61, 95% CI 0.44-0.84; p=0.002) were less likely to receive information., Conclusion: A substantial proportion of patients were not informed about potential ADRs from prescribed pharmacotherapy after PCI. Patients informed about ADRs had lower incidences of self-reported ADRs and fewer concerns about prescribed pharmacotherapy., Competing Interests: Conflict of Interest None., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)

Published
2024
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46. Long-Term Outcomes of Invasive vs Conservative Strategies for Older Patients With Non-ST-Segment Elevation Acute Coronary Syndromes.

Author

Berg ES, Tegn NK, Abdelnoor M, Røysland K, Ryalen PC, Aaberge L, Eek C, Øie E, Juliebø V, Gjertsen E, Ranhoff AH, Gullestad L, Nordstrand N, and Bendz B

Subjects
Aged, 80 and over, Humans, Coronary Angiography methods, Treatment Outcome, Randomized Controlled Trials as Topic, Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome therapy, Myocardial Infarction, Stroke
Abstract

Background: Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is a frequent cause of hospital admission in older people, but clinical trials targeting this population are scarce., Objectives: The After Eighty Study assessed the effect of an invasive vs a conservative treatment strategy in a very old population with NSTE-ACS., Methods: Between 2010 and 2014, the investigators randomized 457 patients with NSTE-ACS aged ≥80 years (mean age 85 years) to an invasive strategy involving early coronary angiography with immediate evaluation for revascularization and optimal medical therapy or to a conservative strategy (ie, optimal medical therapy). The primary endpoint was a composite of myocardial infarction, need for urgent revascularization, stroke, and death. The long-term outcomes are presented., Results: After a median follow up of 5.3 years, the invasive strategy was superior to the conservative strategy in the reduction of the primary endpoint (incidence rate ratio: 0.76; 95% CI: 0.63-0.93; P = 0.0057). The invasive strategy demonstrated a significant gain in event-free survival of 276 days (95% CI: 151-400 days; P = 0.0001) at 5 years and 337 days (95% CI: 123-550 days; P = 0.0001) at 10 years. These results were consistent across subgroups of patients with respect to major cardiovascular prognostic factors., Conclusions: In patients aged ≥80 years with NSTE-ACS, the invasive strategy was superior to the conservative strategy in the reduction of composite events and demonstrated a significant gain in event-free survival. (The After Eighty Study: a randomized controlled trial; NCT01255540)., Competing Interests: Funding Support and Author Disclosures The After Eighty Study is an investigator-initiated study that received funding from the Norwegian Health Association (ExtraStiftelsen) and Inger and John Fredriksen Heart Foundation. Dr Tegn has received grants from the funders. The funders had no role in data collection, analysis, interpretation, writing of the manuscript or the decision to submit the report. All other authors have reported that they have no relationships relevant to the contents of this paper to declare., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2023
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47. Phenotyping Self-Reported Health Profiles in Octogenarians and Nonagenarians After Percutaneous Coronary Intervention: A Latent Profile Analysis.

Author

Instenes I, Breivik K, Borregaard B, Larsen AI, Allore H, Bendz B, Deaton C, Rotevatn S, and Norekvål TM

Subjects
Aged, 80 and over, Humans, Aged, Nonagenarians, Octogenarians, Risk Factors, Self Report, Prospective Studies, Treatment Outcome, Percutaneous Coronary Intervention
Abstract

Background: Little is known about self-reported health in octogenarians (≥80 years) and nonagenarians (≥90 years) following percutaneous coronary intervention (PCI), including characteristics of different health outcomes. This study aimed to phenotype latent health profiles of self-reported health in older adults 2 months post-PCI., Methods: A prospective, multicentre, real-world study (CONCARD PCI ) of 270 octogenarians and nonagenarians was performed with five validated and standardised measures of self-reported health at 2 months post-PCI. Latent profile analysis was used to identify health profiles, and multinomial logistic regression analyses were used to investigate the associations between patient characteristics and health profiles., Results: Three latent health profiles were identified: The Poor health profile included 29%, the Moderate health profile included 39%, and the Good health profile included 32% of the participants. Older adults who were frail (OR 2.50, 95% CI 1.17-5.33), had a low exercise level (OR 0.49, 95% CI 0.39-0.95), and low alcohol intake (OR 0.61, 95% CI 0.39-0.95) were more likely to belong to the Poor health profile relative to the Good health profile. Furthermore, older age (OR 1.19, 95% CI 1.03-1.37) and lower exercise level (OR 0.64, 95% CI 0.43-0.97) were associated with belonging to the Moderate health profile relative to the Good health profile., Conclusion: Two months after PCI, most participants displayed having Moderate to Good health profiles. Those with a Poor health profile were more likely to be frail and less active. These findings highlight that follow-up care has to be patient-centred and tailored to improve the health status of older adults., Competing Interests: Conflict of Interest The authors have no conflict of interest to declare., (Copyright © 2023 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)

Published
2023
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48. An investigator-sponsored pragmatic randomized controlled trial of AntiCoagulation vs AcetylSalicylic Acid after Transcatheter Aortic Valve Implantation: Rationale and design of ACASA-TAVI.

Author

Dodgson CS, Beitnes JO, Kløve SF, Herstad J, Opdahl A, Undseth R, Eek CH, Broch K, Gullestad L, Aaberge L, Lunde K, Bendz B, and Lie ØH

Abstract

Background: The optimal antithrombotic therapy after transcatheter aortic valve implantation (TAVI) is unknown. Bioprosthetic valve dysfunction (BVD) is associated with adverse outcomes and may be prevented by anticoagulation therapy. A dedicated randomized trial comparing monotherapy NOAC to single antiplatelet therapy has not been performed previously. We hypothesize that therapy with any anti-factor Xa NOAC will reduce BVD compared to antiplatelet therapy, without compromising safety., Methods: ACASA-TAVI is a multicenter, prospective, randomized, open-label, blinded endpoint, all-comers trial comparing a monotherapy anti-factor Xa NOAC strategy (intervention arm) with a single antiplatelet therapy strategy (control arm) after successful TAVI. Three-hundred and sixty patients without indication for oral anticoagulation will be randomized in a 1:1 ratio to either apixaban 5 mg twice per day, edoxaban 60 mg daily, or rivaroxaban 20 mg daily for 12 months followed by acetylsalicylic acid 75 mg daily indefinitely, or to acetylsalicylic acid 75 mg daily indefinitely. The 2 co-primary outcomes are (1) incidence of Hypo-Attenuated Leaflet Thickening (HALT) on 4-dimensional cardiac CT at 12 months, and (2) a Safety Composite of VARC-3 bleeding events, thromboembolic events (myocardial infarction and stroke), and death from any cause, at 12 months., Results: The first 100 patients had a mean age of 74 ± 3.6 years, 33% were female, the average body-mass index was 27.9 ± 4.4 kg/m 2 , and 15% were smokers. A balloon-expanded valve was used in 82% and a self-expandable valve in 18%., Conclusions: The trial is planned, initiated, funded, and conducted without industry involvement., Trial Registration: ClinicalTrials.gov Identifier NCT05035277., Competing Interests: Conflict of interest None reported., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2023
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49. Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab.

Author

Woxholt S, Ueland T, Aukrust P, Anstensrud AK, Broch K, Tøllefsen IM, Ryan L, Bendz B, Hopp E, Kløw NE, Seljeflot I, Halvorsen B, Dahl TB, Huse C, Andersen GØ, Gullestad L, Wiseth R, Amundsen BH, Damas JK, and Kleveland O

Subjects
Humans, Interleukin 1 Receptor Antagonist Protein, Interleukin-6, Interleukin-8, C-Reactive Protein, Receptors, Interleukin-6, Cytokines, ST Elevation Myocardial Infarction diagnostic imaging, ST Elevation Myocardial Infarction drug therapy
Abstract

Background: Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab and their correlations with neutrophils, C-reactive protein (CRP), troponin T, MSI and infarct size., Methods: STEMI patients were randomised to receive a single dose of 280 mg tocilizumab (n=101) or placebo (n=98) before percutaneous coronary intervention. Blood samples were collected before infusion of tocilizumab or placebo at baseline, during follow-up at 24-36, 72-168 hours, 3 and 6 months. 27 cytokines were analysed using a multiplex cytokine assay. Cardiac MRI was performed during hospitalisation and 6 months., Results: Repeated measures analysis of variance showed significant (p<0.001) between-group difference in changes for IL-6, IL-8 and IL-1ra due to an increase in the tocilizumab group during hospitalisation. IL-6 and IL-8 correlated to neutrophils in the placebo group (r=0.73, 0.68, respectively), which was attenuated in the tocilizumab group (r=0.28, 0.27, respectively). A similar pattern was seen for MSI and IL-6 and IL-8 in the placebo group (r=-0.29, -0.25, respectively) in patients presenting ≤3 hours from symptom onset, which was attenuated in the tocilizumab group (r=-0.09,-0.14, respectively)., Conclusions: Tocilizumab increases IL-6, IL-8 and IL-1ra in STEMI. IL-6 and IL-8 show correlations to neutrophils/CRP and markers of cardiac injury in the placebo group that was attenuated in the tocilizumab group. This may suggest a beneficial effect of tocilizumab on the ischaemia-reperfusion injury in STEMI patients., Trial Registration Number: NCT03004703., Competing Interests: Competing interests: Roche provided the investigational medicinal products and an unrestricted grant for the ASSAIL-MI study., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)

Published
2023
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50. Effects of high-intensity interval training on cardiac remodelling, function and coronary microcirculation in de novo heart transplant patients: a substudy of the HITTS randomised controlled trial.

Author

Rafique M, Solberg OG, Gullestad L, Bendz B, Murbræch K, Nytrøen K, Rolid K, and Lunde K

Abstract

Objectives: High-intensity interval training (HIT) improves peak oxygen consumption (VO2peak) in de novo heart transplant (HTx) recipients. It remains unclear whether this improvement early after HTx is solely dependent on peripheral adaptations, or due to a linked chain of central and peripheral adaptations. The objective of this study was to determine whether HIT results in structural and functional adaptations in the cardiovascular system., Methods: Eighty-one de novo HTx recipients were randomly assigned to participate in either 9 months of supervised HIT or standard care exercise-based rehabilitation. Cardiac function was assessed by echocardiogram and the coronary microcirculation with the index of microcirculatory resistance (IMR) at baseline and 12 months after HTx., Results: Cardiac function as assessed by global longitudinal strain was significantly better in the HIT group than in the standard care group (16.3±1.2% vs 15.6±2.2%, respectively, treatment effect = -1.1% (95% CI -2.0% to -0.2%), p=0.02), as was the end-diastolic volume (128.5±20.8 mL vs 123.4±15.5 mL, respectively, treatment effect=4.9 mL (95% CI 0.5 to 9.2 mL), p=0.03). There was a non-significant tendency for IMR to indicate improved microcirculatory function (13.8±8.0 vs 16.8±12.0, respectively, treatment effect = -4.3 (95% CI -9.1 to 0.6), p=0.08)., Conclusion: When initiated early after HTx, HIT leads to both structural and functional cardiovascular adaptations., Trial Registration Number: NCT01796379., Competing Interests: Competing interests: MR received institutional research grants from Stiftelsen DAM; LG received personal fees from Astra Zeneca, Boehringer Ingelheim, Novartis, and Amgen during the conduct of the study; None of the other authors have a conflict of interest to disclose., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
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