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22 results on '"Bendjama, Kaidre"'

1. Phase Ib/II trial of tipapkinogene sovacivec, a therapeutic human papillomavirus16-vaccine, in combination with avelumab in patients with advanced human papillomavirus16-positive cancers

Author

Borcoman, Edith, Lalanne, Ana, Delord, Jean-Pierre, Cassier, Philippe A., Rolland, Frédéric, Salas, Sébastien, Limacher, Jean-Marc, Capitain, Olivier, Lantz, Olivier, Ekwegbara, Christina, Jeannot, Emmanuelle, Cyrta, Joanna, Tran-Perennou, Carine, Castel-Ajgal, Zahra, Marret, Grégoire, Piaggio, Eliane, Brandely, Maud, Tavernaro, Annette, Makhloufi, Hakim, Bendjama, Kaidre, and Le Tourneau, Christophe

Published
2023
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2. Abstract LB205: Feasibility and immunogenicity of adjuvant TG4050, a patient tailored cancer vaccine in head and neck and ovarian cancer

Author

Lalanne, Ana, primary, Jamet, Camille, additional, Ottensmeier, Christian H., additional, Delord, Jean-Pierre, additional, Tourneau, Christophe Le, additional, Block, Matthew S., additional, Colon-Otero, Gerardo, additional, Knutson, Keith L., additional, Tavernaro, Annette, additional, Lacoste, Gisele, additional, Grellier, Benoit, additional, Noiriel, Xavier, additional, Huss, Thierry, additional, Burtin, Bernard, additional, Yamashita, Yoshiko, additional, Onoue, Kousuke, additional, Onoguchi, Kazuhide, additional, Malone, Brandon, additional, Lantz, Olivier, additional, Baker, Oliver, additional, Yamagata, Naoko, additional, Tanaka, Yuki, additional, Quemeneur, Eric, additional, Brandely, Maud, additional, and Bendjama, Kaidre, additional

Published
2023
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3. Abstract CT190: Oncolytic virus TG6002 safety and activity after intrahepatic artery administration in patients with liver-dominant metastatic colorectal cancer

Author

Samson, Adel, primary, Smolenschi, Cristina, additional, Cassier, Philippe, additional, Patel, Jai V., additional, Hammond, Chris, additional, Kurzawa, Marta, additional, Sainte-Croix, Sophie, additional, West, Emma, additional, Sadoun, Alain, additional, and Bendjama, Kaidre, additional

Published
2023
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4. Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients

Author

Samson, Adel, primary, West, Emma J., primary, Carmichael, Jonathan, primary, Scott, Karen J., primary, Turnbull, Samantha, primary, Kuszlewicz, Bethany, primary, Dave, Rajiv V., primary, Peckham-Cooper, Adam, primary, Tidswell, Emma, primary, Kingston, Jennifer, primary, Johnpulle, Michelle, primary, da Silva, Barbara, primary, Jennings, Victoria A., primary, Bendjama, Kaidre, primary, Stojkowitz, Nicolas, primary, Lusky, Monika, primary, Prasad, K.R., primary, Toogood, Giles J., primary, Auer, Rebecca, primary, Bell, John, primary, Twelves, Chris J., primary, Harrington, Kevin J., primary, Vile, Richard G., primary, Pandha, Hardev, primary, Errington-Mais, Fiona, primary, Ralph, Christy, primary, Newton, Darren J., primary, Anthoney, Alan, primary, Melcher, Alan A., primary, and Collinson, Fiona, primary

Published
2023
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5. Supplementary Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients

Author

Samson, Adel, primary, West, Emma J., primary, Carmichael, Jonathan, primary, Scott, Karen J., primary, Turnbull, Samantha, primary, Kuszlewicz, Bethany, primary, Dave, Rajiv V., primary, Peckham-Cooper, Adam, primary, Tidswell, Emma, primary, Kingston, Jennifer, primary, Johnpulle, Michelle, primary, da Silva, Barbara, primary, Jennings, Victoria A., primary, Bendjama, Kaidre, primary, Stojkowitz, Nicolas, primary, Lusky, Monika, primary, Prasad, K.R., primary, Toogood, Giles J., primary, Auer, Rebecca, primary, Bell, John, primary, Twelves, Chris J., primary, Harrington, Kevin J., primary, Vile, Richard G., primary, Pandha, Hardev, primary, Errington-Mais, Fiona, primary, Ralph, Christy, primary, Newton, Darren J., primary, Anthoney, Alan, primary, Melcher, Alan A., primary, and Collinson, Fiona, primary

Published
2023
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6. Supplementary Figure from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients

Author

Samson, Adel, primary, West, Emma J., primary, Carmichael, Jonathan, primary, Scott, Karen J., primary, Turnbull, Samantha, primary, Kuszlewicz, Bethany, primary, Dave, Rajiv V., primary, Peckham-Cooper, Adam, primary, Tidswell, Emma, primary, Kingston, Jennifer, primary, Johnpulle, Michelle, primary, da Silva, Barbara, primary, Jennings, Victoria A., primary, Bendjama, Kaidre, primary, Stojkowitz, Nicolas, primary, Lusky, Monika, primary, Prasad, K.R., primary, Toogood, Giles J., primary, Auer, Rebecca, primary, Bell, John, primary, Twelves, Chris J., primary, Harrington, Kevin J., primary, Vile, Richard G., primary, Pandha, Hardev, primary, Errington-Mais, Fiona, primary, Ralph, Christy, primary, Newton, Darren J., primary, Anthoney, Alan, primary, Melcher, Alan A., primary, and Collinson, Fiona, primary

Published
2023
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7. Abstract CT182: Phase I trials of personalized cancer vaccine TG4050 in surgically treated high-risk head and neck squamous cell carcinoma (HNSCC) and relapsing ovarian cancer (OvC) patients

Author

Block, Matthew S., primary, Delord, Jean-Pierre, additional, Ottensmeier, Christian H., additional, Le Tourneau, Christophe, additional, Lalanne, Ana, additional, Lantz, Olivier, additional, Knutson, Keith L., additional, Lacoste, Gisèle, additional, Tavernaro, Annette, additional, Brandely, Maud, additional, Silvestre, Nathalie, additional, Grellier, Benoit, additional, Yamashita, Yoshiko, additional, Kousuke, Onoue, additional, Yamagata, Naoko, additional, Quemeneur, Eric, additional, and Bendjama, Kaidre, additional

Published
2022
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8. Phase 1 studies of personalized neoantigen vaccine TG4050 in ovarian carcinoma (OC) and head and neck squamous cell carcinoma (HNSCC).

Author

Delord, Jean-Pierre, primary, Block, Matthew Stephen, additional, Ottensmeier, Christian, additional, Colon-Otero, Gerardo, additional, Le Tourneau, Christophe, additional, Lalanne, Ana, additional, Jamet, Camille, additional, Lantz, Olivier, additional, Knutson, Keith L., additional, Lacoste, Gisele, additional, TAVERNARO, Annette, additional, Brandely-Talbot, Maud, additional, Silvestre, Nathalie, additional, Grellier, Benoît, additional, Malone, Brandon, additional, Tanaka, Yuki, additional, Onoue, Kousuke, additional, Yamashita, Yoshiko, additional, Quemeneur, Eric, additional, and Bendjama, Kaidre, additional

Published
2022
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9. Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer

Author

McCann, Katy, Von Witzleben, Adrian, Thomas, Jaya, Wang, Chuan, Wood, Oliver, Singh, Divya, Boukas, Konstantinos, Bendjama, Kaidre, Silvestre, Nathalie, Nielsen, Finn Cilius, Thomas, Gareth, Sanchez-Elsner, Tilman, Greenbaum, Jason, Schoenberger, Stephen, Peters, Bjoern, Vijayanand, Pandurangan, Savelyeva, Natalia, Ottensmeier, Christian, McCann, Katy, Von Witzleben, Adrian, Thomas, Jaya, Wang, Chuan, Wood, Oliver, Singh, Divya, Boukas, Konstantinos, Bendjama, Kaidre, Silvestre, Nathalie, Nielsen, Finn Cilius, Thomas, Gareth, Sanchez-Elsner, Tilman, Greenbaum, Jason, Schoenberger, Stephen, Peters, Bjoern, Vijayanand, Pandurangan, Savelyeva, Natalia, and Ottensmeier, Christian

Abstract

Background Cancer is characterized by an accumulation of somatic mutations, of which a significant subset can generate cancer-specific neoepitopes that are recognized by autologous T cells. Such neoepitopes are emerging as important targets for cancer immunotherapy, including personalized cancer vaccination strategies. Methods We used whole-exome and RNA sequencing analysis to identify potential neoantigens for a patient with non-small cell lung cancer. Thereafter, we assessed the autologous T-cell reactivity to the candidate neoantigens using a long peptide approach in a cultured interferon gamma ELISpot and tracked the neoantigen-specific T-cells in the tumor by T-cell receptor (TCR) sequencing. In parallel, identified gene variants were incorporated into a Modified Vaccinia Ankara-based vaccine, which was evaluated in the human leucocyte antigen A∗0201 transgenic mouse model (HHD). Results Sequencing revealed a tumor with a low mutational burden: 2219 sequence variants were identified from the primary tumor, of which 23 were expressed in the transcriptome, involving 18 gene products. We could demonstrate spontaneous T-cell responses to 5/18 (28%) mutated gene variants, and further analysis of the TCR repertoire of neoantigen-specific CD4 + and CD8 + T cells revealed TCR clonotypes that were expanded in both blood and tumor tissue. Following vaccination of HHD mice, de novo T-cell responses were generated to 4/18 (22%) mutated gene variants; T cells reactive against two variants were also evident in the autologous setting. Subsequently, we determined the major histocompatibility complex restriction of the T-cell responses and used in silico prediction tools to determine the likely neoepitopes. Conclusions Our study demonstrates the feasibility of efficiently identifying tumor-specific neoantigens that can be targeted by vaccination in tumors with a low mutational burden, promising successful clinical exploitation, with trials currently underway.

Published
2022

10. Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients

Author

West, Emma J., primary, Scott, Karen J., additional, Tidswell, Emma, additional, Bendjama, Kaidre, additional, Stojkowitz, Nicolas, additional, Lusky, Monika, additional, Kurzawa, Marta, additional, Prasad, Raj, additional, Toogood, Giles, additional, Ralph, Christy, additional, Anthoney, D. Alan, additional, Melcher, Alan A., additional, Collinson, Fiona J., additional, and Samson, Adel, additional

Published
2022
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11. Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients

Author

Samson, Adel, primary, West, Emma J., additional, Carmichael, Jonathan, additional, Scott, Karen J., additional, Turnbull, Samantha, additional, Kuszlewicz, Bethany, additional, Dave, Rajiv V., additional, Peckham-Cooper, Adam, additional, Tidswell, Emma, additional, Kingston, Jennifer, additional, Johnpulle, Michelle, additional, da Silva, Barbara, additional, Jennings, Victoria A., additional, Bendjama, Kaidre, additional, Stojkowitz, Nicolas, additional, Lusky, Monika, additional, Prasad, K.R., additional, Toogood, Giles J., additional, Auer, Rebecca, additional, Bell, John, additional, Twelves, Chris J., additional, Harrington, Kevin J., additional, Vile, Richard G., additional, Pandha, Hardev, additional, Errington-Mais, Fiona, additional, Ralph, Christy, additional, Newton, Darren J., additional, Anthoney, Alan, additional, Melcher, Alan A., additional, and Collinson, Fiona, additional

Published
2022
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12. Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer

Author

McCann, Katy, primary, von Witzleben, Adrian, additional, Thomas, Jaya, additional, Wang, Chuan, additional, Wood, Oliver, additional, Singh, Divya, additional, Boukas, Konstantinos, additional, Bendjama, Kaidre, additional, Silvestre, Nathalie, additional, Nielsen, Finn Cilius, additional, Thomas, Gareth, additional, Sanchez-Elsner, Tilman, additional, Greenbaum, Jason, additional, Schoenberger, Stephen, additional, Peters, Bjoern, additional, Vijayanand, Pandurangan, additional, Savelyeva, Natalia, additional, and Ottensmeier, Christian, additional

Published
2022
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13. A generic operational strategy to qualify translational safety biomarkers

Author

Matheis, Katja, Laurie, David, Andriamandroso, Christiane, Arber, Nadir, Badimon, Lina, Benain, Xavier, Bendjama, Kaïdre, Clavier, Isabelle, Colman, Peter, Firat, Hüseyin, Goepfert, Jens, Hall, Steve, Joos, Thomas, Kraus, Sarah, Kretschmer, Axel, Merz, Michael, Padro, Teresa, Planatscher, Hannes, Rossi, Annamaria, Schneiderhan-Marra, Nicole, Schuppe-Koistinen, Ina, Thomann, Peter, Vidal, Jean-Marc, and Molac, Béatrice

Published
2011
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14. Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination

Author

Ramos, Rodrigo Nalio, primary, Tosch, Caroline, additional, Kotsias, Fiorella, additional, Claudepierre, Marie‐Christine, additional, Schmitt, Doris, additional, Remy‐Ziller, Christelle, additional, Hoffmann, Chantal, additional, Ricordel, Marine, additional, Nourtier, Virginie, additional, Farine, Isabelle, additional, Laruelle, Laurence, additional, Hortelano, Julie, additional, Spring‐Giusti, Clementine, additional, Sedlik, Christine, additional, Le Tourneau, Christophe, additional, Hoffmann, Caroline, additional, Silvestre, Nathalie, additional, Erbs, Philippe, additional, Bendjama, Kaidre, additional, Thioudellet, Christine, additional, Quemeneur, Eric, additional, Piaggio, Eliane, additional, and Rittner, Karola, additional

Published
2022
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16. Abstract LB179: Oncolytic virus TG6002 locates to tumors after intravenous infusion and induces tumor-specific expression of a functional pro-drug activating enzyme in patients with advanced gastrointestinal carcinomas

Author

Bendjama, Kaidre, primary, Cassier, Philippe, additional, Moreno, Victor, additional, Doger, Bernard, additional, Calvo, Emiliano, additional, de Miguel, Maria, additional, Jungels, Christiane, additional, Erbs, Philippe, additional, Carpentier, Damien, additional, and Sadoun, Alain, additional

Published
2021
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17. 793 TG4001 (Tipapkinogene sovacivec) and avelumab for recurrent/metastatic (R/M) human papilloma virus (HPV)-16+ cancers: clinical efficacy and immunogenicity

Author

Tourneau, Christophe Le, primary, Cassier, Philippe, additional, Rolland, Frederic, additional, Salas, Sébastien, additional, Limacher, Jean Marc, additional, Capitain, Olivier, additional, Lantz, Olivier, additional, Lalanne, Ana, additional, Ekwegbara, Christina, additional, Tavernaro, Annette, additional, Makhloufi, Hakim, additional, Bendjama, Kaidre, additional, and Delord, Jean-Pierre, additional

Published
2020
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19. Single intravenous preoperative administration of the oncolytic virus Pexa-Vec to prime anti-tumor immunity.

Author

Anthoney, Alan, primary, Samson, Adel, additional, West, Emma, additional, Turnbull, Samantha Jane, additional, Scott, Karen, additional, Tidswell, Emma, additional, Kingston, Jennifer, additional, Johnpulle, Michelle, additional, Noutch, Samantha, additional, Bendjama, Kaidre, additional, Homerin, Michel, additional, Stojkowitz, Nicolas, additional, Toogood, Giles, additional, Twelves, Chris, additional, Ralph, Christy, additional, Melcher, Alan, additional, and Collinson, Fiona Jane, additional

Published
2018
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20. Safety and immunogenicity of TG4050: A personalized cancer vaccine in head and neck carcinoma.

Author

Ottensmeier, Christian H.H., Delord, Jean-Pierre, Lalanne, Ana, Lantz, Olivier, Jamet, Camille, TAVERNARO, Annette, Brandely-Talbot, Maud, Grellier, Benoît, Bastien, Berangere, Makhloufi, Hakim, Huss, Thierry, Yamashita, Yoshiko, Onoue, Kousuke, Yamagata, Naoko, Tanaka, Yuki, Malone, Brandon, Baker, Oliver, Quemeneur, Eric, Bendjama, Kaidre, and Le Tourneau, Christophe

Published
2023
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21. Immunogenicity and clinical activity of tipapkinogen sovacivec (TG4001), an HPV-16 cancer vaccine: A randomized phase 2 study in advanced anogenital cancers.

Author

Le Tourneau, Christophe, Rolland, Frederic, Capitain, Olivier, Daste, Amaury, Cassier, Philippe Alexandre, Salas, Sebastien, Manso Sánchez, Luis, Casado Herraez, Antonio, Colon-Otero, Gerardo, Eberst, Lauriane, Jamet, Camille, Lalanne, Ana, Lantz, Olivier, Makhloufi, Hakim, TAVERNARO, Annette, Bendjama, Kaidre, Brandely-Talbot, Maud, and Delord, Jean-Pierre

Published
2023
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