1. Evaluation of the corneal epithelium of rabbits treated with preservative-free eye drops containing ketorolac tromethamine or diclofenac sodium
- Author
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Pereira, Fabiana Quartiero, Bender, Melina Barbara, Silva, Tanise Carboni da, Santos, Bruna Santos dos, Hünning, Paula Stieven, Faganello, Cláudia Skilhan, Pacheco, Maira Haase, Mello, João Roberto Braga de, Mello, Fernanda Bastos de, and Pigatto, João Antonio Tadeu
- Subjects
nonsteroidal anti-inflammatory agent ,ophthalmic solutions ,cornea ,solução oftálmica ,microscopia eletrônica de varredura ,antiinflamatório não esteroidal ,córnea ,scanning electron microscopy - Abstract
This study aimed to evaluate the corneal epitheliotoxic effects of preservative-free ketorolac tromethamine 0.5% and diclofenac sodium 0.1% eye drops in rabbits. Seventeen New Zealand rabbits were randomly divided into three groups: the 0.5% ketorolac tromethamine group, the 0.1% diclofenac sodium group, and the control group (0.9% NaCl). For each rabbit, both eyes were treated three times daily according to their treatment group. The corneal epithelia were analyzed using scanning electron microscopy to observe the number of light, grey, and dark cells; the number of epithelial holes; and the loss of hexagonal shape. Both of the formulations administered caused changes in the healthy corneal epithelia of rabbits. Except for number of epithelial holes (p < 0.05), all the parameters showed a statistically significant difference between the groups. The number of dark cells was highest in the ketorolac tromethamine group (p
- Published
- 2023