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3. Gene Therapy Versus Common Care for Eligible Individuals With Sickle Cell Disease in the United States: A Cost-Effectiveness Analysis.

Author

Basu, Anirban, Winn, Aaron N., Johnson, Kate M., Jiao, Boshen, Devine, Beth, Hankins, Jane S., Arnold, Staci D., Bender, M.A., and Ramsey, Scott D.

Subjects
SICKLE cell anemia, GENE therapy, BONE marrow cells, FETAL hemoglobin, ERYTHROCYTES, MEDICAID, DISEASE complications, PRIAPISM
Abstract

The U.S. Food and Drug Administration recently approved 2 genetic therapies for sickle cell disease. Both therapies increase the production of nonsickling red blood cells, either fetal hemoglobin or a gene therapy–derived hemoglobin similar to hemoglobin A. In addition, both therapies require collection of a patient's stem cells, modification of the cells in the laboratory, high-dose chemotherapy to remove existing bone marrow cells, and a single-dose infusion of the patient's modified stem cells. This article uses 2 different cost-effectiveness models to estimate whether these therapies provide enough value to justify their high costs. Visual Abstract. Gene Therapy Versus Common Care for Eligible Individuals With Sickle Cell Disease in the United States: The U.S. Food and Drug Administration recently approved 2 genetic therapies for sickle cell disease. Both therapies increase the production of nonsickling red blood cells, either fetal hemoglobin or a gene therapy–derived hemoglobin similar to hemoglobin A. In addition, both therapies require collection of a patient's stem cells, modification of the cells in the laboratory, high-dose chemotherapy to remove existing bone marrow cells, and a single-dose infusion of the patient's modified stem cells. This article uses 2 different cost-effectiveness models to estimate whether these therapies provide enough value to justify their high costs. Background: Sickle cell disease (SCD) and its complications contribute to high rates of morbidity and early mortality and high cost in the United States and African heritage community. Objective: To evaluate the cost-effectiveness of gene therapy for SCD and its value-based prices (VBPs). Design: Comparative modeling analysis across 2 independently developed simulation models (University of Washington Model for Economic Analysis of Sickle Cell Cure [UW-MEASURE] and Fred Hutchinson Institute Sickle Cell Disease Outcomes Research and Economics Model [FH-HISCORE]) using the same databases. Data Sources: Centers for Medicare & Medicaid Services claims data, 2008 to 2016; published literature. Target Population: Persons eligible for gene therapy. Time Horizon: Lifetime. Perspective: U.S. health care sector and societal. Intervention: Gene therapy versus common care. Outcome Measures: Incremental cost-effectiveness ratios (ICERs), equity-informed VBPs, and price acceptability curves. Results of Base-Case Analysis: At an assumed $2 million price for gene therapy, UW-MEASURE and FH-HISCORE estimated ICERs of $193 000 per QALY and $427 000 per QALY, respectively, under the health care sector perspective. Corresponding estimates from the societal perspective were $126 000 per QALY and $281 000 per QALY. The difference in results between models stemmed primarily from considering a slightly different target population and incorporating the quality-of-life (QOL) effects of splenic sequestration, priapism, and acute chest syndrome in the UW model. From a societal perspective, acceptable (>90% confidence) VBPs ranged from $1 million to $2.5 million depending on the use of alternative effective metrics or equity-informed threshold values. Results of Sensitivity Analysis: Results were sensitive to the costs of myeloablative conditioning before gene therapy, effect on caregiver QOL, and effect of gene therapy on long-term survival. Limitation: The short-term effects of gene therapy on vaso-occlusive events were extrapolated from 1 study. Conclusion: Gene therapy for SCD below a $2 million price tag is likely to be cost-effective when applying a societal perspective at an equity-informed threshold for cost-effectiveness analysis. Primary Funding Source: National Heart, Lung, and Blood Institute. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Contributors

Author

Adams, Trevor L., primary, Adler, Adam C., additional, Ames, Warwick A., additional, Anderson, Brian J., additional, Andropoulos, Dean B., additional, Anixter, Martin B., additional, Arnold, Philip, additional, Baker, Robert, additional, Bender, M.A., additional, Berde, Charles B., additional, Berenstain, Laura K., additional, Blasiole, Brian, additional, Bösenberg, Adrian T., additional, Brown, Karen A., additional, Brusseau, Roland, additional, Cain, James Gordon, additional, Chidambaran, Vidya, additional, Cladis, Franklyn P., additional, Claure, Rebecca E., additional, Cooper, Jeffrey B., additional, Coté, Charles J., additional, Cravero, Joseph P., additional, Crean, Peter M., additional, Davidson, Andrew J., additional, Davis, Peter J., additional, DiNardo, James A., additional, Eisses, Michael J., additional, Fiadjoe, John E., additional, Firth, Paul G., additional, Foreman, John W., additional, Forshaw, Natalie, additional, Fortier, Michelle A., additional, Gangadharan, Sandeep, additional, Gertler, Ralph, additional, Ghazal, Elizabeth A., additional, Goldschneider, Kenneth, additional, Gottlieb, Erin A., additional, Grabowski, Eric F., additional, Grogan, Kelly L., additional, Gulur, Padma, additional, Haberkern, Charles M., additional, Hammer, Gregory B., additional, Hannallah, Raafat S., additional, Hansen, Tom G., additional, Havidich, Jeana E., additional, Henneberg, Steen W., additional, Houghton, James, additional, Jaichenco, Andre L., additional, Kain, Zeev N., additional, Kaplan, Richard F., additional, Karmakar, Manoj K., additional, Kinane, T. Bernard, additional, Krane, Elliot J., additional, Kwok, Wing H., additional, Rolo, Vasco Laginha, additional, Lam, Jennifer E., additional, Landrigan-Ossar, Mary, additional, Latham, Gregory J., additional, Lerman, Jerrold, additional, Lima, Luciana Cavalcanti, additional, Litman, Ronald S., additional, Loepke, Andreas W., additional, Mai, Christine L., additional, Marciniak, Bruno, additional, Martyn, J.A. Jeevendra, additional, Mason, Linda J., additional, Mayes, Linda C., additional, McClain, Craig D., additional, McEwan, Angus, additional, McManus, Michael L., additional, Mendoza, Julianne, additional, Mihm, Frederick G., additional, Miller-Hance, Wanda C., additional, Nawathe, Pooja, additional, Parness, Jerome, additional, Polaner, David M., additional, Rawlinson, Ellen, additional, Rhodes, Erinn T., additional, Ross, Faith J., additional, Ross, Patrick A., additional, Rowe, Echo, additional, Sadhasivam, Senthilkumar, additional, Schleien, Charles L., additional, Schure, Annette Y., additional, Serber, Julia F., additional, Shank, Erik S., additional, Soriano, Sulpicio G., additional, Spaeth, James P., additional, Squires, James E., additional, Squires, Robert H., additional, Stowell, Christopher P., additional, Stricker, Paul A., additional, Suresh, Santhanam, additional, Szabova, Alexandra, additional, Szyld, Demian, additional, Taenzer, Andreas H., additional, Tirupathi, Sandya, additional, Tobin, Joseph R., additional, Vadi, Marissa G., additional, Verghese, Susan T., additional, Waisel, David B., additional, Wald, Samuel H., additional, Walker, Benjamin J., additional, Weaver, R. Grey, additional, Wesson, David E., additional, Wigfall, Delbert R., additional, Wilton, Niall C., additional, Wolfsdorf, Joseph I., additional, and Young, David A., additional

Published
2019
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5. Essentials of Hematology

Author

Adams, Trevor L., primary, Latham, Gregory J., additional, Eisses, Michael J., additional, Bender, M.A., additional, and Haberkern, Charles M., additional

Published
2019
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7. Agglomerative Clustering of Growing Squares

Author

Castermans, Thom, Speckmann, Bettina, Staals, Frank, Verbeek, Kevin, Bender, M.A., Farach-Colton, M., Mosteiro, M.A., Applied Geometric Algorithms, Algorithmic Spatial Data Analysis, EAISI Foundational, EAISI Health, and Algorithms, Geometry and Applications

Subjects
Computational Geometry (cs.CG), FOS: Computer and information sciences, General Computer Science, Computer science, The Intersect, Kinetic data structure, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, 0102 computer and information sciences, 02 engineering and technology, Glyph, Disjoint sets, 01 natural sciences, Square (algebra), Computational geometry, Combinatorics, Set (abstract data type), Computer Science - Data Structures and Algorithms, 0202 electrical engineering, electronic engineering, information engineering, Data Structures and Algorithms (cs.DS), Kinetic data structures, 0101 mathematics, Mathematics, ComputingMethodologies_COMPUTERGRAPHICS, Amortized analysis, business.industry, I.3.5, Applied Mathematics, 010102 general mathematics, Pattern recognition, Binary logarithm, Data structure, Computer Science Applications, Hierarchical clustering, Computer Science::Graphics, 010201 computation theory & mathematics, Computer Science - Computational Geometry, 020201 artificial intelligence & image processing, Artificial intelligence, business, Range trees
Abstract

We study an agglomerative clustering problem motivated by interactive glyphs in geo-visualization. Consider a set of disjoint square glyphs on an interactive map. When the user zooms out, the glyphs grow in size relative to the map, possibly with different speeds. When two glyphs intersect, we wish to replace them by a new glyph that captures the information of the intersecting glyphs. We present a fully dynamic kinetic data structure that maintains a set of $n$ disjoint growing squares. Our data structure uses $O(n (\log n \log\log n)^2)$ space, supports queries in worst case $O(\log^3 n)$ time, and updates in $O(\log^7 n)$ amortized time. This leads to an $O(n\alpha(n)\log^7 n)$ time algorithm to solve the agglomerative clustering problem. This is a significant improvement over the current best $O(n^2)$ time algorithms., Comment: 14 pages, 7 figures

Published
2022

12. List of Contributors

Author

Abbasi, Rania K., Adams, Trevor L., Adler, Adam C., Ames, Warwick A., Anderson, Brian J., Andropoulos, Dean B., Anninger, William, Arnold, Philip, Awad, Motaz, Bailey, Philip D., Jr., Bender, M.A., Berenstain, Laura K., Bösenberg, Adrian T., Braunold, Daniel, Sinai, Yitzhak Brzezinski, Burgart, Alyssa M., Butler, Carolyn G., Carr, Michele M., Carter, Harmony F., Lima, Luciana Cavalcanti, Chidambaran, Vidya, Chua, Annabelle N., Cooper, Jeffrey B., Coté, Charles J., Cravero, Joseph P., Damian, Daniela, Davidson, Andrew J., DiNardo, James A., Docquier, Marie-Agnès, Earley, Timothy M., Eisses, Michael J., Ferschl, Marla B., Fiadjoe, John E., Firth, Paul G., Flannery, Kaitlin M., Gertler, Ralph, Ghazal, Elizabeth A., Goldschneider, Kenneth, Gottlieb, Erin A., Grabowski, Eric F., Hamilton, A. Rebecca L., Hammer, Gregory B., Hansen, Tom G., Havidich, Jeana E., Houghton, James, Hunter, Samuel A., Hylton, Jared R.E., Jaichenco, Andre L., Sr., Jones, Cathie T., Kanmanthreddy, Siri, Karmakar, Manoj Kumar, Kinane, T. Bernard, Kumar, Reeti, Rolo, Vasco Laginha, Lam, Jennifer E., Landrigan-Ossar, Mary, Latham, Gregory J., Lehavi, Amit, Lerman, Jerrold, Loepke, Andreas W., Mai, Christine L., Mandell, Iris, Martin, Lizabeth D., Martyn, J.A. Jeevendra, Masip, Nuria, Mason, Linda J., McClain, Craig D., McEwan, Angus, McManus, Michael L., Mendoza, Julianne, Miller-Hance, Wanda C., Murto, Kimmo, Nassogne, Marie-Cécile, Nawathe, Pooja, Nelson, Olivia, Nichols, John H., Ojo, Bukola, Olbrecht, Vanessa A., Packiasabapathy, Senthil, Pan, Stephanie J., Polaner, David M., Quinlan, Casey A., Rawlinson, Ellen, Rhodes, Erinn T., Rollins, Mark D., Rowe, Echo, Ross, Faith J., Sadhasivam, Senthil, Schleien, Charles L., Schure, Annette Y., Sequera-Ramos, Luis, Sheffy, Nadav, Simhi, Eliahu, Skowno, Justin J., Sloan, Steven R., Soriano, Sulpicio G., Spaeth, James P., Squires, James E., Srivatsa, Abhinash, Stein, Mary Lyn, Stocki, Daniel, Stricker, Paul A., Sunder, Rani, Suresh, Santhanam, Szabova, Alexandra, Taenzer, Andreas H., Vetterly, Carol, Veyckemans, Francis, Waisel, David B., Walker, Benjamin, Wang, Jue Teresa, Welch, John C., Wilton, Niall C., Wolfsdorf, Joseph I., and Yip, Peggy

Published
2025
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16. An expansive human regulatory lexicon encoded in transcription factor footprints

Author

Neph, Shane, Vierstra, Jeff, Stergachis, Andrew B., Reynolds, Alex P., Haugen, Eric, Vernot, Benjamin, Thurman, Robert E., John, Sam, Sandstrom, Richard, Johnson, Audra K., Maurano, Matthew T., Humbert, Richard, Rynes, Eric, Vong, Shinny, Lee, Kristen, Bates, Daniel, Diegel, Morgan, Roach, Vaughn, Dunn, Douglas, Neri, Jun, Schafer, Anthony, Scott Hansen, R., Kutyavin, Tanya, Giste, Erika, Weaver, Molly, Canfield, Theresa, Sabo, Peter, Zhang, Miaohua, Balasundaram, Gayathri, Byron, Rachel, MacCoss, Michael J., Akey, Joshua M., Bender, M.A., Groudine, Mark, Kaul, Rajinder, and Stamatoyannopoulos, John A.

Subjects
Nucleotide sequencing -- Research, DNA sequencing -- Research, Genetic regulation -- Research, Transcription factors -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution 'footprints'. Using genomic DNaseI footprinting across 41 diverse cell and tissue types, we detected 45 million transcription factor occupancy events within regulatory regions, representing differential binding to 8.4 million distinct short sequence elements. Here we show that this small genomic sequence compartment, roughly twice the size of the exome, encodes an expansive repertoire of conserved recognition sequences for DNA-binding proteins that nearly doubles the size of the human cis-regulatory lexicon. We find that genetic variants affecting allelic chromatin states are concentrated in footprints, and that these elements are preferentially sheltered from DNA methylation. High-resolution DNase I cleavage patterns mirror nucleotide-level evolutionary conservation and track the crystallographic topography of protein-DNA interfaces, indicating that transcription factor structure has been evolutionarily imprinted on the human genome sequence. We identify a stereotyped 50-base-pair footprint that precisely defines the site of transcript origination within thousands of human promoters. Finally, we describe a large collection of novel regulatory factor recognition motifs that are highly conserved in both sequence and function, and exhibit cell- selective occupancy patterns that closely parallel major regulators of development, differentiation and pluripotency., Sequence-specific transcription factors interpret the signals encoded within regulatory DNA. The discovery of DNase I footprinting over 30 years ago (1) revolutionized the analysis of cis-regulatory sequences in diverse organisms, [...]

Published
2012
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18. Comprehensive mapping of long-range interactions reveals folding principles of the human genome

Author

Lieberman-Aiden, Erez, van Berkum, Nynke L., Williams, Louise, Imakaev, Maxim, Ragoczy, Tobias, Telling, Agnes, Amit, Ido, Lajoie, Bryan R., Sabo, Peter J. Dorschner, Michael O., Sandstrom, Richard, Bernstein, Bradley, Bender, M.A., Groudine, Mark, Gnirke, Andreas, Stamatoyannopoutos, John, Mirny, Leonid A., Lander, Eric S., and Dekker, Job

Subjects
Human genome -- Identification and classification, Chromosome mapping -- Methods, Protein folding -- Research, Science and technology
Abstract

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1 megabase. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and dosed chromatin to form two genome-wide compartments. At the megabase scare, the chromatin conformation is consistent with a fractal globule, a knot-free, polymer conformation that enables maximally dense packing while preserving the ability to easily fold and unfold any genomic locus. The fractal globule is distinct from the more commonly used globular equilibrium model. Our results demonstrate the power of Hi-C to map the dynamic conformations of whole genomes. 10.1126/science.1181369

Published
2009
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19. Developmental and species-divergent globin switching are driven by BCL11A

Author

Sankaran, Vijay G., Xu, Jian, Ragoczy, Tobias, Ippolito, Gregory C., Walkley, Carl R., Maika, Shanna D., Fujiwara, Yuko, Ito, Masafumi, Groudine, Mark, Bender, M.A., Tucker, Philip W., and Orkin, Stuart H.

Subjects
Immunohistochemistry -- Usage -- Physiological aspects -- Research, Gene expression -- Research -- Physiological aspects -- Genetic aspects -- Usage, Embryonic development -- Research -- Genetic aspects -- Physiological aspects -- Usage, Globin genes -- Research -- Usage -- Genetic aspects -- Physiological aspects, Animal models in research -- Usage -- Research -- Physiological aspects -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Usage, Physiological aspects, Research, Genetic aspects
Abstract

The contribution of changes in cis-regulatory elements or trans-acting factors to interspecies differences in gene expression is not well understood. The mammalian β-globin loci have served as a model for gene regulation during development. Transgenic mice containing the human β-globin locus, consisting of the linked embryonic (ζ), fetal (γ) and adult (β) genes, have been used as a system to investigate the temporal switch from fetal to adult haemoglobin, as occurs in humans. Here we show that the human β-globin (HBG) genes in these mice behave as murine embryonic globin genes, revealing a limitation of the model and demonstrating that critical differences in the trans-acting milieu have arisen during mammalian evolution. We show that the expression of BCL11A, a repressor of human β-globin expression identified by genome-wide association studies, differs between mouse and human. Developmental silencing of the mouse embryonic globin and human β-globin genes fails to occur in mice in the absence of BCL11A. Thus, BCL11A is a critical mediator of species-divergent globin switching. By comparing the ontogeny of β-globin gene regulation in mice and humans, we have shown that alterations in the expression of a trans-acting factor constitute a critical driver of gene expression changes during evolution., The extent to which changes in cis-regulatory elements or the transacting environment account for differences in gene expression in closely related species is the subject of debate (1, 2). Some [...]

Published
2009

20. Enhancers predominantly regulate gene expression during differentiation via transcription initiation

Author

Larke, Martin S.C., primary, Schwessinger, Ron, additional, Nojima, Takayuki, additional, Telenius, Jelena, additional, Beagrie, Robert A., additional, Downes, Damien J., additional, Oudelaar, A. Marieke, additional, Truch, Julia, additional, Graham, Bryony, additional, Bender, M.A., additional, Proudfoot, Nicholas J., additional, Higgs, Douglas R., additional, and Hughes, Jim R., additional

Published
2021
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21. The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation

Author

Ragoczy, Tobias, Bender, M.A., Telling, Agnes, Byron, Rachel, and Groudine, Mark

Subjects
Genetic transcription -- Research, Globin genes -- Research, Hybridization -- Research, Biological sciences
Abstract

The relationship between nuclear localization and transcriptional activity of the endogenous murine beta-globin locus during erythroid differentiation was examined. The results suggested that the locus control region (LCR)-dependent association of the beta-globin locus with transcriptionally engaged polymerase II foci provided the driving force for relocalization of the locus toward the nuclear interior during erythroid maturation.

Published
2006

22. Contributors

Author

Ackerman, Veda L., primary, Adelson, P. David, additional, Agbeko, Rachel S., additional, Almodovar, Melvin C., additional, Alonso, Estella M., additional, Aneja, Raj K., additional, Angus, Derek C., additional, Argent, Andrew C., additional, Aspesberro, Francois P., additional, Bakar, Adnan M., additional, Bambach, Barbara, additional, Bass, Lee M., additional, Bayir, Hülya, additional, Beaulieu, Pierre, additional, Bell, Michael J., additional, Bender, M.A., additional, Benson, Jeffrey C., additional, Benton, Wade W., additional, Berg, Robert A., additional, Berkowitz, Darryl H., additional, Bhutta, Omar J., additional, Biagas, Katherine C., additional, Blatt, Julie, additional, Blowey, Douglas L., additional, Blumer, Jeffrey L., additional, Bradley, John S, additional, Brandom, Barbara W., additional, Brodsky, Linda, additional, Brogan, Thomas V., additional, Brothers, Adam W., additional, Bunchman, Timothy E., additional, Burd, Randall S., additional, Burns, Jeffrey, additional, Bush, Sean P., additional, Bystrak, Louis L., additional, Campbell, Angela J.P., additional, Cannavino, Christopher R., additional, Carcillo, Joseph A., additional, Carrillo-Lopez, Hector, additional, Cassara, Antonio, additional, Caty, Michael G., additional, Charpie, John R., additional, Chavez, Adrian, additional, Christenson, John C., additional, Clark, Jonna D., additional, Clark, Robert S.B., additional, Clement, Katherine C., additional, Coalson, Jacqueline J., additional, Coopersmith, Craig M., additional, Coppola, Christopher P., additional, Corey, Seth J., additional, Cox, Peter N., additional, Cummings, James J., additional, Curley, Martha A.Q., additional, Czosnyka, Marek, additional, D’Angelis, Christopher A., additional, Dahmer, Mary K., additional, Dalton, Heidi J., additional, Davis, Peter J., additional, Morena, M. Theresa de la, additional, Oliveira, Cláudio Flauzino de, additional, Dhanani, Sonny, additional, Dobyns, Emily L., additional, Donner, Elizabeth J., additional, Doughty, Lesley, additional, Dreyfuss, Didier, additional, Duncan, Christine, additional, Durand, Philippe, additional, Duthie, Susan, additional, Eigen, Howard, additional, Maamoun El-Dawy, Waleed M., additional, Elliott, Steven, additional, Emery, Helen M., additional, Escobar, Mauricio A., additional, Evans, Jacqueline M., additional, Felmet, Kate, additional, Fineman, Jeffrey R., additional, Fink, Ericka L., additional, Fiser, Richard T., additional, Fish, Frank A., additional, Fletcher, James E., additional, Forbes, Michael J., additional, Fort, Amber E., additional, Fost, Norman, additional, Frader, Joel E., additional, Franzon, Deborah E., additional, Fricker, F. Jay, additional, Friess, Stuart, additional, Fuhrman, Bradley P., additional, Garcia-Casal, Xiomara, additional, Gauvin, France, additional, Gaynor, J. William, additional, Gilad, Eli, additional, Gilbert, James C., additional, Glaser, Nicole S., additional, Goldstein, Stuart L., additional, Goodman, Denise M., additional, Graciano, Ana Lía, additional, Gunnarsson, Björn, additional, Hahn, Cecil D., additional, Hall, Mark, additional, Hamilton, Melinda Fiedor, additional, Han, Yong Y., additional, Hanson, Cherissa, additional, Harding, Cary O., additional, Hartman, Mary E., additional, Hazelzet, Jan A., additional, Heard, Christopher M.B., additional, Heine, Ann Marie, additional, Hernan, Lynn J., additional, Hertzig, Jeremy S., additional, Heulitt, Mark J., additional, Hoffman, Julien I.E., additional, Huhta, James C., additional, Ichord, Rebecca, additional, Inglis, Andrew, additional, Linggi Irby, Gretchen A., additional, Jacobs, Brian, additional, Jardine, David, additional, Jarillo-Quijada, Alberto, additional, Javouey, Etienne, additional, Jefferis Kirk, Christa C., additional, Johns, James A., additional, Joshi, Prashant, additional, Kagan, Richard J., additional, Kannankeril, Prince J., additional, Kanter, Robert K., additional, Karam, Oliver, additional, Kasten, Kevin R., additional, Kelly, Michael, additional, Khanna, Paritosh C., additional, Kochanek, Patrick M., additional, Kocis, Keith C., additional, Kocoshis, Samuel A., additional, Koves, Ildiko H., additional, Kulik, Thomas J., additional, Kumar, Vasanth H., additional, Lacroix, Jacques, additional, Lakshminrusimha, Satyan, additional, Langley, Joanne M., additional, Laussen, Peter C., additional, Levin, Daniel L., additional, Lewis-Newby, Mithya, additional, Lieh-Lai, Mary W., additional, Lindsey, Daphne, additional, Litalien, Catherine, additional, Lynch, Robert E., additional, Makley, Amy T., additional, Marcin, James P., additional, Mariscalco, Mary Michele, additional, Markovitz, Barry, additional, Martin, Lynn D., additional, Maxvold, Norma J., additional, Mazur, Paula M., additional, McArthur, Jennifer A., additional, McLaughlin, Jerry, additional, McLaughlin, Gwenn E., additional, Redwine, Karen McNiece, additional, Mehta, Nilesh M., additional, Mehta, Renuka, additional, Melvin, Ann J., additional, Menon, Sharad, additional, Mian, Ayesa N., additional, Michelson, Kelly, additional, Michienzi, Kelly A., additional, Moloney-Harmon, Patricia A., additional, Monagle, Paul, additional, Moss, Michele M., additional, Mou, Steven S., additional, Muenzer, Jared T., additional, Nadkarni, Vinay, additional, Nakagawa, Thomas A., additional, Naran, Navyn, additional, Nguyen, Trung, additional, Nicholson, Carol E., additional, Nielsen, Katie R., additional, Northway, Tracie, additional, Norwood, Victoria F., additional, Notterman, Daniel A., additional, Nowak, Jeffrey E., additional, Oishi, Peter, additional, Orr, Richard A., additional, Ouellette, Yves, additional, Parakininkas, Daiva, additional, Parker, Margaret M., additional, Pearson-Shaver, Tony, additional, Pérez Fontán, J. Julio, additional, Peters, Mark, additional, Pihoker, Catherine, additional, Pinsk, Maury N., additional, Pollack, Murray M., additional, Pon, Steven, additional, Quasney, Michael, additional, Rajasekaran, Surender, additional, Rampersad, Sally E., additional, Ranjit, Suchitra, additional, Reade, Erin P., additional, Reese Jr., James J., additional, Relvas, Monica, additional, Remy, Kenneth E., additional, Ricard, Jean-Damien, additional, Rice, Tom B., additional, Ridling, Debra Ann, additional, Roberts, Joan S., additional, Ross, Ashley S., additional, Roth, Kimberly R., additional, Rotta, Alexandre T., additional, Rowin, Mark E., additional, Roy, John, additional, Rubino, Christopher M., additional, Ruppel, Randall A., additional, Rushton, Cynda H., additional, Ryan, Rita M., additional, Salonia, Rosanne, additional, Salvin, Joshua, additional, Sanders Jr., Ronald C., additional, Sarnaik, Ajit A., additional, Sarnaik, Ashok P., additional, Saumon, Georges, additional, Sawin, Robert, additional, Scanlon, Matthew C., additional, Schenkman, Kenneth A., additional, Schexnayder, Stephen M., additional, Schleien, Charles L., additional, Schwartz, George J., additional, Schwartz, Steven M., additional, Shann, Frank, additional, Shaw, Dennis W.W., additional, Shemie, Sam D., additional, Shoykhet, Mish, additional, Sivarajan, V. Ben, additional, Skippen, Peter W., additional, Slonim, Anthony D., additional, Smith, Laurie, additional, Smith, Lincoln S., additional, Standage, Stephen W., additional, Steinberg, Joel B., additional, Steinhorn, David M., additional, Stojanovski, Sasko D., additional, Storm, Elizabeth A., additional, Stroud, Michael H., additional, Sturgill, Marc G., additional, Sutton, Robert M., additional, Symons, Jordan M., additional, Tailounie, Muayyad, additional, Talano, Julie-An, additional, Tamburro Jr., Robert, additional, Tasker, Robert C., additional, Thompson, Ann E., additional, Tilton, Ann H., additional, Tinmouth, Alan, additional, Tobias, Joseph D., additional, Tobin, Nicole H., additional, Todres, I. David, additional, Tucci, Marisa, additional, Ulate, Kalia P., additional, Valentine, Kevin M., additional, Vaughan, David J., additional, Venkataraman, Shekhar T., additional, Visoiu, Mihaela, additional, von Saint André–von Arnim, Amélie, additional, Wainwright, Mark S., additional, Wakeham, Martin K., additional, Watson, R. Scott, additional, Webb, Ashley N., additional, Weigle, Carl, additional, Weimer, Maria B., additional, Wessel, David L., additional, Wetzel, Randall C., additional, Wong, Hector R., additional, Wood, Ellen G., additional, Woolf, Alan D., additional, Woytash, James J., additional, Yanay, Ofer, additional, Zaritsky, Arno, additional, Zerr, Danielle M., additional, and Zimmerman, Jerry J., additional

Published
2011
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25. Contributors

Author

Anderson, Brian, primary, Andropoulos, Dean B., additional, Anixter, Miriam, additional, Bender, M.A., additional, Berde, Charles, additional, Berry, Frederic A., additional, Bissonnette, Bruno, additional, Blum, Richard H., additional, Bosenberg, Adrian T., additional, Brown, Karen A., additional, Brusseau, Roland, additional, Cain, James, additional, Chang, Anthony, additional, Chi, Carolyn I., additional, Cladis, Franklyn, additional, Cot é, Charles J., additional, Cravero, Joseph P., additional, Crawford, Mark W., additional, Crean, Peter, additional, Davidson, Andrew J., additional, Davis, Peter J., additional, DeSoto, Hernando, additional, Diaz, Laura K., additional, Eisses, Michael J., additional, Engelhardt, Thomas, additional, Everett, Lucinda L., additional, Firth, Paul G., additional, Foreman, John, additional, Fuzaylov, Gennadiy, additional, Gertler, Ralph, additional, Ghazal, Elizabeth A., additional, Goldschneider, Kenneth, additional, Goudsouzian, Nishan, additional, Grabowski, Eric F., additional, Haberkern, Charles M., additional, Hammer, Gregory B., additional, Hannallah, Raafat S., additional, Haver, Kenan E., additional, Hicks, Elaine, additional, Insoft, Robert M., additional, Jaichenco, Andre, additional, Kain, Zeev N., additional, Kaplan, Richard F., additional, Karmakar, Manoj K., additional, Koka, Babu V., additional, Krane, Elliot J., additional, Kurth, C. Dean, additional, Kwok, Wing H., additional, Lane, Geoffrey K., additional, Lerman, Jerrold, additional, Lichtenstein, Steven, additional, Lönnqvist, Per-Arne, additional, Luginbuehl, Igor, additional, Lugo, Ralph A., additional, MacLaren, Jill, additional, Malviya, Shobha, additional, Martyn, J.A. Jeevendra, additional, Mason, Keira P., additional, Mason, Linda J., additional, Mayes, Linda C., additional, McClain, Craig D., additional, McEwan, Angus, additional, McGowan, Francis X., additional, McManus, Michael L., additional, Miller-Hance, Wanda C., additional, Morris, Marilyn C., additional, Morton, Neil S., additional, Murat, Isabelle, additional, Myers, Laura B., additional, Neely, E. Kirk, additional, Parness, Jerome, additional, Polaner, David M., additional, Rhodes, Erinn T., additional, Rivera, Marcus R., additional, Roberts, Jesse D., additional, Rockoff, Mark A., additional, Romanelli, Thomas M., additional, Ross, Allison Kinder, additional, Schleien, Charles L., additional, Shank, Erik S., additional, Sheridan, Robert L., additional, Shukla, Avinash C., additional, Skinner, Adam, additional, Slesnick, Timothy C., additional, Soriano, Sulpicio G., additional, Spaeth, James P., additional, Squires, Robert H., additional, Steven, James M., additional, Stough, Robert C., additional, Stowell, Christopher P., additional, Suresh, Santhanam, additional, Szabova, Alexandra, additional, Taenzer, Andreas, additional, Tepas, Joseph J., additional, Tobin, Joseph R., additional, Todres, I. David, additional, Truog, Robert D., additional, Verghese, Susan T., additional, Waisel, David B., additional, Wald, Samuel H., additional, Ward, Robert M., additional, Weaver, R. Grey, additional, Webel, Nicole E., additional, West, Rebecca W., additional, Wheeler, Melissa, additional, Wigfall, Delbert R., additional, Wilton, Niall, additional, Wolf, Andrew, additional, Wolfsdorf, Joseph I., additional, and Yaster, Myron, additional

Published
2009
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28. Atlas and developmental dynamics of mouse DNase I hypersensitive sites

Author

Breeze, Charles E., primary, Lazar, John, additional, Mercer, Tim, additional, Halow, Jessica, additional, Washington, Ida, additional, Lee, Kristen, additional, Ibarrientos, Sean, additional, Castillo, Andres, additional, Neri, Fidencio, additional, Haugen, Eric, additional, Rynes, Eric, additional, Reynolds, Alex, additional, Bates, Daniel, additional, Diegel, Morgan, additional, Dunn, Douglas, additional, Kaul, Rajinder, additional, Sandstrom, Richard, additional, Meuleman, Wouter, additional, Bender, M.A., additional, Groudine, Mark, additional, and Stamatoyannopoulos, John A., additional

Published
2020
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29. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes

Author

Bulger, Michael, Doorninck, J. Hikke von, Saitoh, Noriko, Telling, Agnes, Farrell, Catherine, Bender, M.A., Felsenfeld, Gary, Axel, Richard, and Groudine, Mark

Subjects
Human genetics -- Research, Mice -- Genetic aspects, Nucleotide sequence -- Research, Science and technology
Abstract

In mouse and human, the [Beta]-globin genes reside in a linear array that is associated with a positive regulatory element located 5[prime] to the genes known as the locus control region (LCR). The sequences of the mouse and human [Beta]-globin LCRs are homologous, indicating conservation of an essential function in [Beta]-globin gene regulation. We have sequenced regions flanking the [Beta]-globin locus in both mouse and human and found that homology associated with the LCR is more extensive than previously known, making up a conserved block of [approximately equal to]40 kb. In addition, we have identified DNaseI-hypersensitive sites within the newly sequenced regions in both mouse and human, and these structural features also are conserved. Finally, we have found that both mouse and human [Beta]-globin loci are embedded within an array of odorant receptor genes that are expressed in olfactory epithelium, and we also identify an olfactory receptor gene located 3[prime] of the [Beta]-globin locus in chicken. The data demonstrate an evolutionarily conserved genomic organization for the [Beta]-globin locus and suggest a possible role for the [Beta]-globin LCR in control of expression of these odorant receptor genes and/or the presence of mechanisms to separate regulatory signals in different tissues.

Published
1999

31. Contributors

Author

Abecassis, Isaac Josh, Abeysekera, Jayani, Adelson, P. David, Agbeko, Rachel S., Agus, Michael S.D., Ahmed, Mubbasheer, Akhondi-Asl, Alireza, Albert, Ben D., Alcamo, Alicia, Alder, Matthew N., Alibrahim, Omar, Allareddy, Veerajalandhar, Almodovar, Melvin C., Aminoff, Alexandra, Amlie-Lefond, Catherine, Aneja, Rajesh, Apple, Abigail, Argent, Andrew C., Arvedson, Joan C., Aspesberro, François, Atlas, Nir, Baatz, John E., Baden, Harris P., Bakar, Adnan M., Banker, Katherine, Barker, Piers C.A., Bass, Lee M., Basu, Rajit K., Bayir, Hülya, Becker, Lance B., Bell, Jamie L., Bell, Michael J., Bembea, Melania M., Bender, M.A., Benscoter, Alexis L., Benton, Wade W., Berg, Robert A., Berkman, Emily, Berkowitz, Carol, Biagas, Katherine V., Bishop, Naomi B., Blatt, Julie, Bodilly, Lauren, Bonow, Robert H., Bragg, E. Alexis, Brandom, Barbara W., Brilli, Richard J., Brogan, Thomas V., Bronicki, Ronald A., Browd, Samuel R., Bunchman, Timothy E., Burns, Jeffrey P., Butler, David F., Caglar, Derya, Camitta, Michael W., Campbell, M. Jay, Campbell, Sally, Capek, Karel D., Carboni, Michael P., Carcillo, Joseph A., Cassara, Antonio, Censoplano, Nina, Chadwick, Victoria, Chamberlain, Reid C., Chan, Anny, Charpie, John R., Cheifetz, Ira M., Chiwane, Saurabh, Chun, Robert H., Clark, Jeff, Clark, Jonna D., Clark, Robert S.B., Clawson, April, Clayton, Jason A., Conlon, Thomas, Conrad, Carol, Conway, Edward E., Jr, Coopersmith, Craig M., Corey, Seth J., Dahmer, Mary K., Dalton, Heidi J., Damania, Rahul C., Damian, Mihaela A., Dartois, Lauren, Davis, Peter J., Dervan, Leslie A., Deutschman, Clifford S., Dezfulian, Cameron, Dick, André A.S., Diekema, Douglas S., Dingeldein, Michael, Doctor, Allan, Downes, John J., Duncan, Christine, Edwards, Christopher M., Edwards, Lauren R., Egbuta, Chinyere, Eigen, Howard, Elfassy, Hannah Laure, Ellis, Alison M., Evans, Idris V.R., Farris, Reid W.D., Fineman, Jeffrey R., Fink, Ericka L., Fish, Frank A., Fitzgerald, Tamara N., Fleming, Gregory A., Flores, Saul, Flynn, Joseph T., Forbes, Michael L., Forbess, Joseph M., Franzon, Deborah E., Frazier, W. Joshua, Fuhrman, Bradley P., Ginther, Richard M., Jr, Glaser, Nicole, Graciano, Ana Lia, Gray, Megan M., Greathouse, Kristin C., Greenwald, Bruce M., Grinsell, Matthew M., Grunwell, Jocelyn R., Gunnarsson, Björn, Guzman, Marla, Hahn, Timothy, Hall, Mark W., Harding, Cary O., Hartman, Mary E., Hartmann, Silvia M., Havlin, Kevin M., Hayward, Kristen, Healey, Patrick J., Heard, Christopher M.B., Heneghan, Julia A., Herndon, David N., Hernan, Lynn J., Hill, Kevin D., Hoffman, Julien I., Holinski, Paula, Hong, Sue J., Horslen, Simon, Hoskote, Aparna, Hotz, Justin C., Ibsen, Laura Marie, Ijsselstijn, Hanneke, Jackson, Travis C., Jamal, Shelina M., Joshi, Prashant, Joyce, Emily L., Kallay, Tom, Kamat, Pradip P., Kane, Jason M., Kannankeril, Prince J., Karam, Oliver, Kenningham, Katherine L., Khalatbari, Hedieh, Khemani, Robinder G., Killien, Elizabeth Y., Kim, Yun, Kingsley, Jenny, Kirk, Christa Jefferis, Kirmani, Sonya, Kleinpell, Ruth, Kochanek, Patrick M., Kocis, Keith C., Kocoshis, Samuel A., Koves, Ildiko H., Kudchadkar, Sapna R., Kulik, Thomas J., Lacroix, Jacques, Lebet, Ruth, Lee, Amy, Lenker, Hallie, Levin, Daniel L., Levy, Emily R., Lewis-Newby, Mithya, Lin, John C., Maddux, Aline, Malone, Matthew P., Manole, Mioara, Marsh, Anne, Martin, Richard J., Mathur, Mudit, McArthur, Jennifer, McCusker, Christine, McDonald, Ruth A., Mehta, Nilesh M., Melvin, Ann J., Menon, Shina, Monagle, Paul, Morgan, Ryan W., Morgenstern, Peter F., Morowitz, Michael J., Morrison, Wynne, Munshi, Raj, Muszynski, Jennifer A., Nadkarni, Vinay M., Naiditch, Jessica A., Nakagawa, Thomas A., Nguyen, Vu, Nickless, Jenna R., Nishisaki, Akira, Norwood, Victoria F., Notterman, Daniel A., Oishi, Peter, Ojemann, Jeffrey, Olson, Michelle L., O’Neal, Jessie, Orloff, Kirsten, Otteson, Todd, Ouellette, Yves, Parakininkas, Daiva, Parker, Robert I., Peeler, Katherine Ratzen, Perez, Francisco A., Perry, Melvin G., Jr, Peters, Mark J., Pfeiffer, Brent J., Phelan, Rachel, Philip, Joseph, Pinto, Neethi, Pollack, Murray M., Preston, Thomas J., Prodhan, Parthak, Quang, Lawrence, Quasney, Michael W., Raffay, Thomas M., Rajapreyar, Prakadeshwari, Rakes, Lauren, Ramos-Jimenez, Rafael G., Ray, Samiran, Reed, Christopher R., Reese, James J., Jr, Rehder, Kyle J., Remy, Kenneth E., Reyes, Jorge D., Rhee, Eileen, Richardson, Clare, Roberts, Joan S., Guerineau, Luciana Rodriguez, Rogers, Stephen, Rotta, Alexandre T., Rowin, Mark E., Ruppel, Randall, Ryan, Rita M., Said, Ahmed, Sallee, Colin J., Sandler, Britt Julia, Sankar, Jhuma, Sarnaik, Ajit A., Sarnaik, Ashok P., Sawin, Robert, Schenkman, Kenneth A., Schexnayder, Stephen M., Schleien, Charles L., Schwartz, Stephanie P., Schwartz, Steven M., Shah, Jay, Shah, Sareen, Shaw, Dennis W.W., Shein, Steven L., Shoykhet, Michael, Simon, Dennis W., Sivarajan, V. Ben, Slain, Katherine N., Smith, Jodi M., Smith, Lincoln S., Sochet, Anthony A., Sorce, Lauren R., Sousse, Linda E., Spaeder, Michael C., Speicher, Richard H., Spinella, Philip C., Stalets, Erika L., Standage, Stephen Wade, Stark, Rebecca, Starr, Michelle C., Steinhorn, David M., Stenmark, Kurt R., Stewart, Claire A., Stollings, Lindsay M., Stulce, Casey, Su, Erik, Summers, Corinne, Sutton, Robert M., Symons, Jordan M., Sznycer-Taub, Nathaniel R., Tamburro, Robert T., Jr, Tapking, Christian, Tasker, Robert C., Tatum, Gregory H., Tilton, Ann H., Timlin, Matthew R., Tissieres, Pierre, Tobias, Joseph D., Toltzis, Philip, Topjian, Alexis A., Torgerson, Troy, Traube, Chani, Tucci, Marisa, Tuggle, David, Turi, Jennifer L., Turner, David A., Cleave, Alisa Van, van der Velden, Meredith G., Vogel, Adam M., Vohwinkel, Christine, Andre-von Arnim, Amelie von Saint, Vora, Surabhi B., Waghmare, Alpana, Wainwright, Mark S., Wallisch, Jessica S., Watson, R. Scott, Watt, Kevin, Weimer, Maria, Weiss, Scott L., Wenger, Jesse, Wheeler, Derek S., Wieczorek, Beth, Wilhelm, Michael, Wong, Hector R., Woods, Charles R., Jr, Woodward, George A. (Tony), Yang, Amy C., Yu, Heidi, Zane, Nicole R., Zerr, Danielle M., Zhang, Hui, Zheng, Hengqi (Betty), Zimmerman, Jerry J., Zimmerman, Kanecia, Zinter, Matt S., and Zuppa, Athena F.

Published
2022
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32. Tight kernels for covering and hitting

Author

Boissonnat, Jean Daniel, Dutta, Kunal, Ghosh, Arijit, Kolay, Sudeshna, Bender, M.A., Farach-Colton, M., Mosteiro, M.A., and Algorithms, Geometry and Applications

Subjects
Polynomial, 0102 computer and information sciences, 02 engineering and technology, 01 natural sciences, Combinatorics, Set (abstract data type), Integer, Cover (topology), Hyperplane, 010201 computation theory & mathematics, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Point (geometry), Mathematics, Vector space
Abstract

The Point Hyperplane Cover problem in \(\mathbb {R}^d\) takes as input a set of n points in \(\mathbb {R}^d\) and a positive integer k. The objective is to cover all the given points with a set of at most k hyperplanes. The D-Polynomial Points Hitting Set (D-Polynomial Points HS) problem in \(\mathbb {R}^d\) takes as input a family \(\mathcal {F}\) of D-degree polynomials from a vector space \(\mathcal {R}\) in \(\mathbb {R}^d\), and determines whether there is a set of at most k points in \(\mathbb {R}^d\) that hit all the polynomials in \(\mathcal {F}\). For both problems, we exhibit tight kernels where k is the parameter.

Published
2018

33. A framework for algorithm stability and its application to kinetic euclidean MSTs

Author

Meulemans, Wouter, Speckmann, Bettina, Verbeek, Kevin, Wulms, Jules, Bender, M.A., Farach-Colton, M., Mosteiro, M.A., Algorithms, Geometry and Applications, and Applied Geometric Algorithms

Subjects
Computer science, Numerical analysis, Euclidean geometry, Stability (learning theory), Context (language use), Variety (universal algebra), Kinetic energy, Algorithm, Topology (chemistry)
Abstract

We say that an algorithm is stable if small changes in the input result in small changes in the output. This kind of algorithm stability is particularly relevant when analyzing and visualizing time-varying data. Stability in general plays an important role in a wide variety of areas, such as numerical analysis, machine learning, and topology, but is poorly understood in the context of (combinatorial) algorithms. In this paper we present a framework for analyzing the stability of algorithms. We focus in particular on the tradeoff between the stability of an algorithm and the quality of the solution it computes. Our framework allows for three types of stability analysis with increasing degrees of complexity: event stability, topological stability, and Lipschitz stability. We demonstrate the use of our stability framework by applying it to kinetic Euclidean minimum spanning trees.

Published
2018

37. Mooie Verhalen De literaire en esthetische aspecten van parabels

Author

Bender, M.A., van Stralen, J.J.M. (Thesis Advisor), Bender, M.A., and van Stralen, J.J.M. (Thesis Advisor)

Abstract

Bachelor eindwerkstuk waarin de literaire en esthetische aspecten van een joodse en een christelijke parabel worden besproken aan de hand van de theorieën van Roman Ingarden.

Published
2017

43. Contributors

Author

Abecassis, Isaac Josh, Agbeko, Rachel S., Adelson, P. David, Alder, Matthew N., Al Ibrahim, Omar, Almodovar, Melvin C., Aminoff, Alexandra R., Amlie-LeFond, Catherine, Angus, Derek C., Arvedson, Joan C., Aspesberro, Francois, Baatz, John E., Baden, Harris P., Badugu, Srinivasarao, Bakar, Adnan M., Banker, Katherine, Bass, John L., Bayir, Hülya, Beaulieu, Pierre, Becker, Lance B., Bell, Michael J., Bender, M.A., Benton, Wade W., Berg, Robert A., Biagas, Katherine V., Bishop, Naomi B., Blatt, Julie, Blowey, Douglas L., Blumer, Jeffrey L., Bonow, Robert H., Brandom, Barbara W., Brilli, Richard J., Brogan, Thomas V., Bronicki, Ronald A., Browd, Samuel R., Bunchman, Timothy E., Burns, Jeffrey P., Caglar, Derya, Campbell, Sally, Carcillo, Joseph A., Carrillo-Lopez, Hector, Cashen, Katherine, Cassara, Antonio, Charpie, John R., Chavez, Adrian, Chun, Robert H., Clark, Jonna Derbenwick, Clark, Robert S.B., Clement, Katherine C., Conlon, Thomas, Conway, Edward E., Jr., Coopersmith, Craig M., Corey, Seth J., Cox, Peter N., Curley, Martha A.Q., Czosnyka, Marek, Dalton, Heidi J., Damian, Mihaela, Davis, Peter J., de Prost, Nicolas, Deutschman, Clifford S., Dezfulian, Cameron, Diekema, Douglas S., Doctor, Allan, Doherty, Meaghan, Dorfman, Molly V., Downes, John J., Dreyfuss, Didier, Duncan, Christine, Dupree, Phylicia D., Eigen, Howard, El-Hassan, Nahed, Eriksson, Carl O., Felmet, Kate, Fineman, Jeffrey R., Fink, Ericka L., Fish, Frank A., Fitzgerald, Tamara N., Flynn, Joseph T., Pérez Fontán, J. Julio, Forbes, Michael J., Forbess, Joseph M., Franzon, Deborah E., Frazier, W. Joshua, Fricker, F. Jay, Fuhrman, Bradley P., Garcia-Casal, Xiomara, Gardner, Rebecca, Gilad, Eli, Ginther, Richard M., Jr., Glaser, Nicole, Goodman, Denise M., Graciano, Ana Lía, Greathouse, Kristin C., Greenwald, Bruce M., Gunnarsson, Björn, Gupta, Punkaj, Hall, Mark W., Han, Yong Y., Harding, Cary O., Hartman, Mary E., Hartmann, Silvia M., Heard, Christopher M.B., Hernan, Lynn J., Heulitt, Mark J., Hoffman, Julien I., Horslen, Simon, Hunyady, Agnes I., Ibsen, Laura Marie, IJsselstijn, Hanneke, Inglis, Andrew, Jr., Irby, Gretchen A. Linggi, Irby, Olivia K., Ishak, Gisele E., Jackson, Travis C., Jacob, Susan, Jamal, Shelina M., Jardine, David, Jarillo, Alberto, Jeziorski, Alison M., Joashi, Umesh, Joshi, Prashant, Kagan, Richard J., Kannankeril, Prince J., Kanter, Robert K., Karam, Oliver, Kaspar, Cristin D.W., Khemani, Robinder G., King, Mary A., Kirk, Christa C. Jefferis, Kissoon, Niranjan (Tex), Kochanek, Patrick M., Kocis, Keith C., Kocoshis, Samuel A., Koh, Tsingyi, Kong, Ada, Koves, Ildiko H., Kulik, Thomas J., Kumar, Vasanth H., Lacroix, Jacques, Lakshminrusimha, Satyan, Lee, Thomas J., Leiner, Marie, Levin, Daniel L., Lewis-Newby, Mithya, Lieh-Lai, Mary W., Litalien, Catherine, Lopez-Magallon, Alejandro, Lynch, Robert, Lyons, John D., Maiyegun, Sitratullah, Makley, Amy T., Maldonado, Alfredo, Markovitz, Barry, Mazur, Paula M., McArthur, Jennifer, McLaughlin, Gwenn E., McLean, Susan F., Mehta, Nilesh M., Mehta, Renuka, Melvin, Ann J., Mian, Ayesa N., Mittal, Rohit, Moloney-Harmon, Patricia A., Monagle, Paul, Moorthy, Chet, Morrison, Wynne, Munoz, Ricardo, Munshi, Raj, Murthy, Srinivas, Muszynski, Jennifer A., Nadkarni, Vinay M., Nakagawa, Thomas A., Naran, Navyn, Neumayr, Tara M., Nishisaki, Akira, Norwood, Victoria F., Notterman, Daniel A., Nugent, Alan W., Oishi, Peter, Ojemann, Jeffrey, Orr, Richard A., Ouellette, Yves, Parakininkas, Daiva, Parker, Robert I., Pasala, Sanjiv, Pearson-Shaver, Tony, Peinado, Jesus, Peters, Mark J., Pfeiffer, Brent J., Phillipi, Carrie A., Pinsk, Maury N., Pollack, Murray M., Pon, Steven, Preston, Tom, Rajapreyar, Prakad, Ray, Samiran, Reade, Erin P., Remy, Kenneth E., Rhee, Eileen, Ricard, Jean-Damien, Richardson, Nicole L., Roberts, Joan S., Rogers, Stephen, Roth, Kimberly R., Rotta, Alexandre T., Rowin, Mark E., Rubin, Lewis P., Ruppel, Randall, Ryan, Rita M., Said, Ahmed, Sainte-Thomas, Nagela, Salonia, Rosanne, Sambalingam, Devaraj, Nelson Sanchez-Pinto, L., Sandquist, Mary, Sarnaik, Ajit A., Sarnaik, Ashok P., Saumon, Georges, Sawin, Robert, Scanlon, Matthew C., Schenkman, Kenneth A., Schexnayder, Stephen M., Schleien, Charles L., Schwartz, George J., Schwartz, Steven M., Schwenk, Hayden T., Seibel, Gabrielle Douthitt, Shaw, Dennis W.W., Shein, Steven L., Shepard, Charles W., Shoykhet, Michael, Simon, Dennis W., Sivarajan, V. Ben, Skippen, Peter, Smith, Lincoln S., Spaeder, Michael C., Speicher, Richard H., Spinella, Philip C., Standage, Stephen, Steinhorn, David M., Stewart, Claire, Storm, Elizabeth A., Stroud, Michael H., Su, Erik, Sutton, Robert M., Symons, Jordan M., Talano, Julie-An, Tamburro, Robert T., Jr., Tasker, Robert C., Thompson, Ann E., Tilton, Ann H., Tobias, Joseph D., Todres, I. David, Torgerson, Troy, Traube, Chani, Tucci, Marisa, Turner, David A., Tyroch, Alan H., Cleave, Alisa Van, van der Velden, Meredith G., Vaughan, David J., Vazquez, Erika, Venkataraman, Shekhar T., Visoiu, Mihaela, von Saint André-von Arnim, Amélie, Vora, Surabhi B., Waghmare, Alpana, Wainwright, Mark S., Wakeham, Martin, Wallace, Carol A., Wallisch, Jessica S., Watson, R. Scott, Webb, Ashley N., Weiss, Scott L., Wenger, Jesse, Wheeler, Derek S., Wilson, Harry, Wong, Hector R., Wood, Ellen Glenn, Woolf, Alan D., Yaghmai, Beryl F., Yanay, Ofer, Zerr, Danielle M., Zheng, Hengqi (Betty), and Zimmerman, Jerry J.

Published
2017
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48. Alteração nos teores de carbono e fósforo orgânico em um Latossolo após 23 anos sob diferentes preparos de solo e culturas de inverno

Author

CASALI, C.A., TIECHER, T., SANTOS, D.R., CALEGARI, A., PICCIN, R., BENDER, M.A., GUBIANI, E., BELLINASO, R.J.S., Schaefer, G., CASALI, C.A., TIECHER, T., SANTOS, D.R., CALEGARI, A., PICCIN, R., BENDER, M.A., GUBIANI, E., BELLINASO, R.J.S., and Schaefer, G.

Abstract

O fósforo (P) orgânico é importante fonte de fosfato para as plantas, tanto em ambientes naturais quanto em solos cultivados. O cultivo de plantas com alta capacidade de reciclagem de P pode aumentar a importância das formas orgânicas na disponibilização de fosfato, especialmente quando o solo não é revolvido O presente estudo objetivou avaliar em um solo muito argiloso sob longo período de cultivo (i) o efeito de diferentes preparos de solo e (ii) o efeito do cultivo de diferentes espécies de plantas de inverno, no teor de carbono e fósforo orgânico do solo. Em 1986 foi estabelecido o experimento com seis tratamentos de inverno (tremoço azul, ervilhaca peluda, aveia preta, nabo forrageiro, trigo e pousio) implantados num Latossolo Vermelho Aluminoférrico na região sudoeste do Paraná, sob sistema plantio direto (SPD) e sistema de cultivo convencional (SCC). As amostras de solo foram coletadas em outubro de 2009 em cinco profundidades (0-5, 5-10, 10-20, 20-30 e 30-40 cm). Sistemas de manejo do solo conservacionistas, como o SPD, aumentam o teor de carbono e fósforo orgânico total do solo da camada superficial comparativamente ao SCC, mas não é suficiente para recuperar os teores de carbono orgânico total original do solo sob mata nativa. O cultivo de plantas durante o inverno aumenta o teor de carbono orgânico total do solo independentemente do sistema de manejo de solo adotado, mas não altera o teor de P orgânico total do solo estimado pelo método de ignição.

Published
2012

49. A Functional Element Necessary for Fetal Hemoglobin Silencing

Author

Sankaran, Vijay G., primary, Xu, Jian, additional, Byron, Rachel, additional, Greisman, Harvey A., additional, Fisher, Chris, additional, Weatherall, David J., additional, Sabath, Daniel E., additional, Groudine, Mark, additional, Orkin, Stuart H., additional, Premawardhena, Anuja, additional, and Bender, M.A., additional

Published
2011
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50. Cohesin Mediates Chromatin Interactions That Regulate Mammalian β-globin Expression

Author

Chien, Richard, primary, Zeng, Weihua, additional, Kawauchi, Shimako, additional, Bender, M.A., additional, Santos, Rosaysela, additional, Gregson, Heather C., additional, Schmiesing, John A., additional, Newkirk, Daniel A., additional, Kong, Xiangduo, additional, Ball, Alexander R., additional, Calof, Anne L., additional, Lander, Arthur D., additional, Groudine, Mark T., additional, and Yokomori, Kyoko, additional

Published
2011
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