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4. Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4Muscarinic Receptor

Author

Qi, Aidong, primary, Kling, Haley E., additional, Billard, Natasha, additional, Rodriguez, Alice L., additional, Peng, Li, additional, Dickerson, Jonathan W., additional, Engers, Julie L., additional, Bender, Aaron M., additional, Moehle, Mark S., additional, Lindsley, Craig W., additional, Rook, Jerri M., additional, and Niswender, Colleen M., additional

Published
2023
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6. Supplementary Figure 3 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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7. Supplementary Table 5 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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8. Supplementary Table 3 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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9. Data from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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10. Supplementary Figure 2 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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11. Supplementary Table 2 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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12. Supplementary Table 4 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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13. Supplementary Figure 4 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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14. Data from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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15. Supplementary Table 3 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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16. Supplementary Table 1 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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17. Supplementary Figure 2 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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18. Supplementary Table 2 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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19. Supplementary Figure 1 from Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Author

Bender, Aaron M., primary, Collier, Lara S., primary, Rodriguez, Fausto J., primary, Tieu, Christina, primary, Larson, Jon D., primary, Halder, Chandralekha, primary, Mahlum, Eric, primary, Kollmeyer, Thomas M., primary, Akagi, Keiko, primary, Sarkar, Gobinda, primary, Largaespada, David A., primary, and Jenkins, Robert B., primary

Published
2023
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20. Supplementary Table 1 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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21. Supplementary Figure 1 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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22. Supplementary Table 4 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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23. Supplementary Figure 3 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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24. Supplementary Figure 4 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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30. Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist

Author

Spock, Matthew, primary, Carter, Trever R., additional, Bollinger, Katrina A., additional, Han, Changho, additional, Baker, Logan A., additional, Rodriguez, Alice L., additional, Peng, Li, additional, Dickerson, Jonathan W., additional, Qi, Aidong, additional, Rook, Jerri M., additional, O’Neill, Jordan C., additional, Watson, Katherine J., additional, Chang, Sichen, additional, Bridges, Thomas M., additional, Engers, Julie L., additional, Engers, Darren W., additional, Niswender, Colleen M., additional, Conn, P. Jeffrey, additional, Lindsley, Craig W., additional, and Bender, Aaron M., additional

Published
2021
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31. Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy

Author

Moehle, Mark S., primary, Bender, Aaron M., additional, Dickerson, Jonathan W., additional, Foster, Daniel J., additional, Qi, Aidong, additional, Cho, Hyekyung P., additional, Donsante, Yuping, additional, Peng, Weimin, additional, Bryant, Zoey, additional, Stillwell, Kaylee J., additional, Bridges, Thomas M., additional, Chang, Sichen, additional, Watson, Katherine J., additional, O’Neill, Jordan C., additional, Engers, Julie L., additional, Peng, Li, additional, Rodriguez, Alice L., additional, Niswender, Colleen M., additional, Lindsley, Craig W., additional, Hess, Ellen J., additional, Conn, P. Jeffrey, additional, and Rook, Jerri M., additional

Published
2021
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32. lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans

Author

Bender, Aaron M., Kirienko, Natalia V., Olson, Sara K., Esko, Jeffery D., and Fay, David S.

Subjects
Biological sciences
Abstract

Byline: Aaron M. Bender (a), Natalia V. Kirienko (a), Sara K. Olson (b), Jeffery D. Esko (b), David S. Fay (a) Keywords: lin-35; Retinoblastoma; spr-1; CoREST; C. elegans; Development Abstract: Using a genetic screen to identify genes that carry out redundant functions during development with lin-35/Rb, the C. elegans Retinoblastoma family ortholog, we have identified a mutation in spr-1. spr-1 encodes the C. elegans ortholog of human CoREST, a protein containing Myb-like SANT and ELM2 domains, which functions as part of a transcriptional regulatory complex. CoREST recruits mediators of transcriptional repression, including histone deacetylase, and demethylase, and interacts with the tumor suppression protein REST. spr-1/CoREST was previously shown in C. elegans to suppress defects associated with loss of the presenilin sel-12, which functions in the proteolytic processing of LIN-12/Notch. Here we show that lin-35 and spr-1 coordinately regulate several developmental processes in C. elegans including the ingression of vulval cells as well as germline proliferation. We also show that loss of lin-35 and spr-1 hypersensitizes animals to a reduction in LIN-12/Notch activity, leading to the generation of proximal germline tumors. This defect, which is observed in lin-35; spr-1; lin-12(RNAi) and lin-35; spr-1; hop-1(RNAi) triple mutants is likely due to a delay in the entry of germ cells into meiosis. Author Affiliation: (a) University of Wyoming, College of Agriculture, Department of Molecular Biology, Department 3944, 1000 E. University Avenue, Laramie, WY 82071, USA (b) Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA Article History: Received 18 July 2006; Revised 28 August 2006; Accepted 30 September 2006

Published
2007

33. Discovery of the first selective M4muscarinic acetylcholine receptor antagonists within vivoanti-parkinsonian and anti-dystonic efficacy

Author

Moehle, Mark S., primary, Bender, Aaron M., additional, Dickerson, Jonathan W., additional, Foster, Daniel J., additional, Donsante, Yuping, additional, Peng, Weimin, additional, Bryant, Zoey, additional, Bridges, Thomas M., additional, Chang, Sichen, additional, Watson, Katherine J., additional, O’Neill, Jordan C., additional, Engers, Julie L., additional, Peng, Li, additional, Rodriguez, Alice L., additional, Niswender, Colleen M., additional, Lindsley, Craig W., additional, Hess, Ellen J., additional, Conn, P. Jeffrey, additional, and Rook, Jerri M., additional

Published
2020
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34. Lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans

Author

Bender, Aaron M., Wells, Orion, and Fay, David S.

Subjects
Developmental biology -- Research, Caenorhabditis elegans -- Research, Caenorhabditis elegans -- Genetic aspects, Gonads -- Research, Gonads -- Genetic aspects, Biological sciences
Abstract

In screens for genetic modifiers of lin-35/Rb, the C. elegans retinoblastoma protein (Rb) homolog, we have identified a mutation in xnp-1. Mutations in xnp-1, including a presumed null allele, are viable and, in general, appear indistinguishable from the wild type. In contrast, xnp-1 lin-35 double mutants are typically sterile and exhibit severe defects in gonadal development. Analyses of the abnormal gonads indicate a defect in the lineages that generate cells of the sheath and spermatheca. xnp-1 encodes the C. elegans homolog of ATR-X, a human disease gene associated with severe forms of mental retardation and urogenital developmental defects. xnp-1/ATR-X is a member of the Swi2/Snf2 family of ATP-dependent DEAD/DEAH box helicases, which function in nucleosome remodeling and transcriptional regulation. Expression of an xnp-1::GFP promoter fusion is detected throughout C. elegans development in several cell types including neurons and cells of the somatic gonad. Our findings demonstrate a new biological role for Rb family members in somatic gonad development and implicate lin-35 in the execution of multiple cell fates in C. elegans. In addition, our results suggest a possible conserved function for xnp-1/ATR-X in gonadal development across species. Keywords: lin-35; Retinoblastoma; xnp-1; ATR-X; C. elegans; Development

Published
2004

39. Biased M 1 receptor–positive allosteric modulators reveal role of phospholipase D in M 1 -dependent rodent cortical plasticity

Author

Moran, Sean P., primary, Xiang, Zixiu, additional, Doyle, Catherine A., additional, Maksymetz, James, additional, Lv, Xiaohui, additional, Faltin, Sehr, additional, Fisher, Nicole M., additional, Bender, Aaron M., additional, Niswender, Colleen M., additional, Rook, Jerri M., additional, Lindsley, Craig W., additional, and Conn, P. Jeffrey, additional

Published
2019
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41. The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate

Author

Panarese, Joseph D., primary, Engers, Darren W., additional, Wu, Yong-Jin, additional, Guernon, Jason M., additional, Chun, Aspen, additional, Gregro, Alison R., additional, Bender, Aaron M., additional, Capstick, Rory A., additional, Wieting, Joshua M., additional, Bronson, Joanne J., additional, Macor, John E., additional, Westphal, Ryan, additional, Soars, Matthew, additional, Engers, Julie E., additional, Felts, Andrew S., additional, Rodriguez, Alice L., additional, Emmitte, Kyle A., additional, Jones, Carrie K., additional, Blobaum, Anna L., additional, Jeffrey Conn, P., additional, Niswender, Colleen M., additional, Hopkins, Corey R., additional, and Lindsley, Craig W., additional

Published
2019
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45. Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M1Positive Allosteric Modulators

Author

Engers, Julie L., primary, Bender, Aaron M., additional, Kalbfleisch, Jacob J., additional, Cho, Hyekyung P., additional, Lingenfelter, Kaelyn S., additional, Luscombe, Vincent B., additional, Han, Changho, additional, Melancon, Bruce J., additional, Blobaum, Anna L., additional, Dickerson, Jonathan W., additional, Rook, Jerri M., additional, Niswender, Colleen M., additional, Emmitte, Kyle A., additional, Conn, P. Jeffrey, additional, and Lindsley, Craig W., additional

Published
2018
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46. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Author

Kharade, Sujay V., primary, Kurata, Haruto, additional, Bender, Aaron M., additional, Blobaum, Anna L., additional, Figueroa, Eric E., additional, Duran, Amanda, additional, Kramer, Meghan, additional, Days, Emily, additional, Vinson, Paige, additional, Flores, Daniel, additional, Satlin, Lisa M., additional, Meiler, Jens, additional, Weaver, C. David, additional, Lindsley, Craig W., additional, Hopkins, Corey R., additional, and Denton, Jerod S., additional

Published
2018
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48. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

Author

Bender, Aaron M., primary, Cho, Hyekyung P., additional, Nance, Kellie D., additional, Lingenfelter, Kaelyn S., additional, Luscombe, Vincent B., additional, Gentry, Patrick R., additional, Voigtritter, Karl, additional, Berizzi, Alice E., additional, Sexton, Patrick M., additional, Langmead, Christopher J., additional, Christopoulos, Arthur, additional, Locuson, Charles W., additional, Bridges, Thomas M., additional, Chang, Sichen, additional, O’Neill, Jordan C., additional, Zhan, Xiaoyan, additional, Niswender, Colleen M., additional, Jones, Carrie K., additional, Conn, P. Jeffrey, additional, and Lindsley, Craig W., additional

Published
2018
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