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773 results on '"Bendahl, Pär-Ola"'

6. RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer

Author

Staaf, Johan, Häkkinen, Jari, Hegardt, Cecilia, Saal, Lao H., Kimbung, Siker, Hedenfalk, Ingrid, Lien, Tonje, Sørlie, Therese, Naume, Bjørn, Russnes, Hege, Marcone, Rachel, Ayyanan, Ayyakkannu, Brisken, Cathrin, Malterling, Rebecka R., Asking, Bengt, Olofsson, Helena, Lindman, Henrik, Bendahl, Pär-Ola, Ehinger, Anna, Larsson, Christer, Loman, Niklas, Rydén, Lisa, Malmberg, Martin, Borg, Åke, and Vallon-Christersson, Johan

Published
2022
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7. Preoperative prediction of nodal status using clinical data and artificial intelligence derived mammogram features enabling abstention of sentinel lymph node biopsy in breast cancer.

Author

Rejmer, Cornelia, Dihge, Looket, Bendahl, Pär-Ola, Förnvik, Daniel, Dustler, Magnus, and Rydén, Lisa

Subjects
SENTINEL lymph node biopsy, BREAST biopsy, ARTIFICIAL intelligence, CLINICAL prediction rules, BREAST cancer, SENTINEL lymph nodes, MAMMOGRAMS
Abstract

Introduction: Patients with clinically node-negative breast cancer have a negative sentinel lymph node status (pN0) in approximately 75% of cases and the necessity of routine surgical nodal staging by sentinel lymph node biopsy (SLNB) has been questioned. Previous prediction models for pN0 have included postoperative variables, thus defeating their purpose to spare patients non-beneficial axillary surgery. We aimed to develop a preoperative prediction model for pN0 and to evaluate the contribution of mammographic breast density and mammogram features derived by artificial intelligence for de-escalation of SLNB. Materials and methods: This retrospective cohort study included 755 women with primary breast cancer. Mammograms were analyzed by commercially available artificial intelligence and automated systems. The additional predictive value of features was evaluated using logistic regression models including preoperative clinical variables and radiological tumor size. The final model was internally validated using bootstrap and externally validated in a separate cohort. A nomogram for prediction of pN0 was developed. The correlation between pathological tumor size and the preoperative radiological tumor size was calculated. Results: Radiological tumor size was the strongest predictor of pN0 and included in a preoperative prediction model displaying an area under the curve of 0.68 (95% confidence interval: 0.63-0.72) in internal validation and 0.64 (95% confidence interval: 0.59-0.69) in external validation. Although the addition of mammographic features did not improve discrimination, the prediction model provided a 21% SLNB reduction rate when a false negative rate of 10% was accepted, reflecting the accepted false negative rate of SLNB. Conclusion: This study shows that the preoperatively available radiological tumor size might replace pathological tumor size as a key predictor in a preoperative prediction model for pN0. While the overall performance was not improved by mammographic features, one in five patients could be omitted from axillary surgery by applying the preoperative prediction model for nodal status. The nomogram visualizing the model could support preoperative patient-centered decision-making on the management of the axilla. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Health-related quality of life by type of breast surgery in women with primary breast cancer: prospective longitudinal cohort study.

Author

Gulis, Kim, Ellbrant, Julia, Bendahl, Pär-Ola, Svensjö, Tor, and Rydén, Lisa

Subjects
BREAST surgery, MAMMAPLASTY, QUALITY of life, BREAST cancer surgery, BREAST cancer, LUMPECTOMY
Abstract

Background Health-related quality of life and patient-related outcome measures for patients with cancer have gained increased interest over the last decade. However, few prospective studies with longitudinal data evaluated health-related quality of life in patients with breast cancer. This study aimed to investigate how health-related quality of life changed from the time of diagnosis to 1 year after breast cancer surgery for the main surgical techniques. Methods This prospective longitudinal single-centre study included patients with primary breast cancer diagnosed in 2019–2020 who underwent surgery. Patients completed a health-related quality of life questionnaire (Breast-Q) at baseline. One year after surgery, they completed the Breast-Q a second time, the EORTC (European Organization for Research and Treatment of Cancer) quality of life questionnaire-C30 and the quality of life questionnaire-BR23. Analysis of variance and Kruskal–Wallis tests were used to evaluate the differences in health-related quality of life between surgical groups. Analysis of covariance with robust standard errors was used to adjust for confounders. Results In total, 340 patients were included in the study; 160 patients received oncoplastic partial mastectomy, 112 received partial mastectomy, 42 received mastectomy and 26 had mastectomy with immediate reconstruction. Patients that had partial mastectomy or oncoplastic partial mastectomy were more satisfied with their breasts (P < 0.001), had a better body image (P = 0.006) and higher sexual functioning scores (P = 0.027) than patients who had a mastectomy with/without reconstruction. The oncoplastic and mastectomy with reconstruction groups had more breast symptoms than other groups (P < 0.001), and the mastectomy group had the least symptoms from the chest area. Conclusion Partial mastectomy and oncoplastic partial mastectomy have the best outcomes in terms of breast satisfaction, body image and sexual functioning. This highlights the importance of preserving the breast when feasible and underscores that breast reconstruction is not equal to breast conservation. Registration number: NCT04227613 (http://www.clinicaltrials.gov). [ABSTRACT FROM AUTHOR]

Published
2024
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15. Protocol for the T-REX-trial: tailored regional external beam radiotherapy in clinically node-negative breast cancer patients with 1-2 sentinel node macrometastases – an open, multicentre, randomised non-inferiority phase 3 trial

Author

Alkner, Sara, primary, de Boniface, Jana, additional, Lundstedt, Dan, additional, Mjaaland, Ingvil, additional, Ryden, Lisa, additional, Vikstrom, Johan, additional, Bendahl, Pär-Ola, additional, Holmberg, Erik, additional, Sackey, Helena, additional, Wieslander, Elinore, additional, and Karlsson, Per, additional

Published
2023
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16. Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer

Author

Lundgren, Christine, Bendahl, Pär-Ola, Borg, Åke, Ehinger, Anna, Hegardt, Cecilia, Larsson, Christer, Loman, Niklas, Malmberg, Martin, Olofsson, Helena, Saal, Lao H., Sjöblom, Tobias, Lindman, Henrik, Klintman, Marie, Häkkinen, Jari, Vallon-Christersson, Johan, Fernö, Mårten, Rydén, Lisa, and Ekholm, Maria

Published
2019
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25. Supplementary Figure S2 from G Protein–Coupled Estrogen Receptor Is Apoptotic and Correlates with Increased Distant Disease-Free Survival of Estrogen Receptor–Positive Breast Cancer Patients

Author

Broselid, Stefan, primary, Cheng, Benxu, primary, Sjöström, Martin, primary, Lövgren, Kristina, primary, Klug-De Santiago, Heather L.P., primary, Belting, Mattias, primary, Jirström, Karin, primary, Malmström, Per, primary, Olde, Björn, primary, Bendahl, Pär-Ola, primary, Hartman, Linda, primary, Fernö, Mårten, primary, and Leeb-Lundberg, L.M. Fredrik, primary

Published
2023
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26. Figure S1 from Prediction of Lymph Node Metastasis in Breast Cancer by Gene Expression and Clinicopathological Models: Development and Validation within a Population-Based Cohort

Author

Dihge, Looket, primary, Vallon-Christersson, Johan, primary, Hegardt, Cecilia, primary, Saal, Lao H., primary, Häkkinen, Jari, primary, Larsson, Christer, primary, Ehinger, Anna, primary, Loman, Niklas, primary, Malmberg, Martin, primary, Bendahl, Pär-Ola, primary, Borg, Åke, primary, Staaf, Johan, primary, and Rydén, Lisa, primary

Published
2023
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27. Supplementary Methods, Figures 3-5 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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29. Supplementary Table 4 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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30. Supplementary Table 3 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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31. Supplementary Figure 2 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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32. Supplementary Table 2 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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33. Supplementary Figure 1 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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34. Supplementary Table 1 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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35. Supplementary Figure Legends 53 from Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Author

Harbst, Katja, primary, Staaf, Johan, primary, Lauss, Martin, primary, Karlsson, Anna, primary, Måsbäck, Anna, primary, Johansson, Iva, primary, Bendahl, Pär-Ola, primary, Vallon-Christersson, Johan, primary, Törngren, Therese, primary, Ekedahl, Henrik, primary, Geisler, Jürgen, primary, Höglund, Mattias, primary, Ringnér, Markus, primary, Lundgren, Lotta, primary, Jirström, Karin, primary, Olsson, Håkan, primary, Ingvar, Christian, primary, Borg, Åke, primary, Tsao, Hensin, primary, and Jönsson, Göran, primary

Published
2023
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36. Appendix S1 from Prediction of Lymph Node Metastasis in Breast Cancer by Gene Expression and Clinicopathological Models: Development and Validation within a Population-Based Cohort

Author

Dihge, Looket, primary, Vallon-Christersson, Johan, primary, Hegardt, Cecilia, primary, Saal, Lao H., primary, Häkkinen, Jari, primary, Larsson, Christer, primary, Ehinger, Anna, primary, Loman, Niklas, primary, Malmberg, Martin, primary, Bendahl, Pär-Ola, primary, Borg, Åke, primary, Staaf, Johan, primary, and Rydén, Lisa, primary

Published
2023
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37. Supplementary Table S1 from G Protein–Coupled Estrogen Receptor Is Apoptotic and Correlates with Increased Distant Disease-Free Survival of Estrogen Receptor–Positive Breast Cancer Patients

Author

Broselid, Stefan, primary, Cheng, Benxu, primary, Sjöström, Martin, primary, Lövgren, Kristina, primary, Klug-De Santiago, Heather L.P., primary, Belting, Mattias, primary, Jirström, Karin, primary, Malmström, Per, primary, Olde, Björn, primary, Bendahl, Pär-Ola, primary, Hartman, Linda, primary, Fernö, Mårten, primary, and Leeb-Lundberg, L.M. Fredrik, primary

Published
2023
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48. Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer: a long‐term follow‐up of the SweBCG91RT randomized trial

Author

Egelberg, Moa, primary, De Marchi, Tommaso, additional, Pekar, Gyula, additional, Tran, Lena, additional, Bendahl, Pär‐Ola, additional, Stenmark Tullberg, Axel, additional, Holmberg, Erik, additional, Karlsson, Per, additional, Farnebo, Marianne, additional, Killander, Fredrika, additional, and Nimeús, Emma, additional

Published
2023
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