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Intraoperative cardiac arrest presents a significant challenge in surgical settings, particularly in patients with undiagnosed cardiac conditions. This report details the case of a 62-year-old male patient who experienced cardiac arrest during elective laparoscopic cholecystectomy, attributed to previously undiagnosed hypertrophic cardiomyopathy (HCM). The patient exhibited no prior cardiac symptoms and was assessed as low risk preoperatively. Following prompt cardiopulmonary resuscitation (CPR) and defibrillation, return of spontaneous circulation (ROSC) was achieved after approximately 10 minutes. Post-resuscitation, echocardiography confirmed significant left ventricular hypertrophy, leading to a new diagnosis of HCM. This case emphasizes the necessity of thorough cardiovascular evaluation in high-risk surgical patients and outlines effective management strategies for intraoperative emergencies., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Mehdi et al.)