1. Exploring the Origin of the Thermal Sensitivity of Near-Infrared-II Emitting Rare Earth Nanoparticles
- Author
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Hamraoui, Khouloud, Torres Vera, Vivian Andrea, Zabala Gutierrez , Irene, Casillas Rubio , Alejandro, Alqudwa Fattouh , Mohammed, Benayas , Antonio, Marín , Riccardo, Natile , Marta María, Manso Silván, Miguel, Rubio Zuazo, Juan, Jaque, Daniel, Melle , Sonia, Gómez Calderón , Oscar, Rubio Retama , Jorge, Rubio Retama, Benito Jorge, Gómez Calderón, Óscar, Melle Hernández, Sonia, Zabala Gutiérrez, Irene, Hamraoui, Khouloud, Torres Vera, Vivian Andrea, Zabala Gutierrez , Irene, Casillas Rubio , Alejandro, Alqudwa Fattouh , Mohammed, Benayas , Antonio, Marín , Riccardo, Natile , Marta María, Manso Silván, Miguel, Rubio Zuazo, Juan, Jaque, Daniel, Melle , Sonia, Gómez Calderón , Oscar, Rubio Retama , Jorge, Rubio Retama, Benito Jorge, Gómez Calderón, Óscar, Melle Hernández, Sonia, and Zabala Gutiérrez, Irene
- Abstract
Rare-earth doped nanoparticles (RENPs) are attracting increasing interest in materials science due to their optical, magnetic, and chemical properties. RENPs can emit and absorb radiation in the second biological window (NIR-II, 1000-1400 nm) making them ideal optical probes for photoluminescence (PL) in vivo imaging. Their narrow emission bands and long PL lifetimes enable autofluorescence-free multiplexed imaging. Furthermore, the strong temperature dependence of the PL properties of some of these RENPs makes remote thermal imaging possible. This is the case of neodymium and ytterbium co-doped NPs that have been used as thermal reporters for in vivo diagnosis of, for instance, inflammatory processes. However, the lack of knowledge about how the chemical composition and architecture of these NPs influence their thermal sensitivity impedes further optimization. To shed light on this, we have systematically studied their emission intensity, PL decay time curves, absolute PL quantum yield, and thermal sensitivity as a function of the core chemical composition and size, active-shell, and outer-inert-shell thicknesses. The results revealed the crucial contribution of each of these factors in optimizing the NP thermal sensitivity. An optimal active shell thickness of around 2 nm and an outer inert shell of 3.5 nm maximize the PL lifetime and the thermal response of the NPs due to the competition between the temperature-dependent back energy transfer, the surface quenching effects, and the confinement of active ions in a thin layer. These findings pave the way for a rational design of RENPs with optimal thermal sensitivity., Comunidad de Madrid (España), Universidad Complutense de Madrid (España), Ministerio de Ciencia e Innovación de España, European Commission- Horizon 2020, Banco Santander (España), Depto. de Óptica, Depto. de Química en Ciencias Farmacéuticas, Fac. de Óptica y Optometría, Fac. de Farmacia, TRUE, pub
- Published
- 2024