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Background: Deep inspiration breath hold (DIBH) reduces radiotherapy cardiac dose for left-sided breast cancer patients. The BRAVEHeart (Breast Radiotherapy Audio Visual Enhancement for sparing the Heart) trial will assess the accuracy and usability of a novel device, Breathe Well, for DIBH guidance for left-sided breast cancer patients. Breathe Well will be compared to an adapted widely available monitoring system, the Real-time Position Monitoring system (RPM).Methods: BRAVEHeart is a single institution prospective randomised trial of two DIBH devices. BRAVEHeart will assess the DIBH accuracy for Breathe Well and RPM during left-sided breast cancer radiotherapy. After informed consent has been obtained, 40 patients will be randomised into two equal groups, the experimental arm (Breathe Well) and the control arm (RPM with in-house modification of an added patient screen). The primary hypothesis of BRAVEHeart is that the accuracy of Breathe Well in maintaining the position of the chest during DIBH is superior to the RPM system. Accuracy will be measured by comparing chest wall motion extracted from images acquired of the treatment field during breast radiotherapy for patients treated using the Breathe Well system and those using the RPM system.Discussion: The Breathe Well device uses a depth camera to monitor the chest surface while the RPM system monitors a block on the patient abdomen. The hypothesis of this trial is that the chest surface is a better surrogate for the internal chest wall motion used as a measure of treatment accuracy. The Breathe Well device aims to deliver an easy to use implementation of surface monitoring. The findings from the study will help inform the technology choice for other centres performing DIBH.Trial registration: This trial was registered on ClinicalTrials.gov on 26 August 2016. The identifier is: NCT02881203. (https://clinicaltrials.gov/ct2/show/NCT02881203).