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9 results on '"Bemelmans, R.H.H."'

1. Lupus anticoagulant associates with thrombosis in patients with COVID‐19 admitted to intensive care units: A retrospective cohort study

Author

Noordermeer, Tessa, Schutgens, Roger E.G., Visser, Chantal, Rademaker, Emma, de Maat, Moniek P.M., Jansen, A.J. Gerard, Limper, Maarten, Cremer, Olaf L., Kruip, Marieke J.H.A., Endeman, Henrik, Maas, Coen, de Laat, Bas, Urbanus, Rolf T., van de Beek, D., Brouwer, M.C., de Bruin, S., Coppens, M., van Es, N., van Haaps, T.F., Juffermans, N.P., Muller, M.C.A., Vlaar, A.P.J., Hertogh, C.M.P.M., Heunks, L.M.A., Hugtenburg, J.G., van Kooten, J., Nossent, E.J., Smulders, Y., Tuinman, P.R., Vonk Noordegraaf, A., Grootenboers, M.J.J.H., van Guldener, C., Kant, M., Lansbergen, A., Faber, J., Hajer, G., Stemerdink, A., van den Akker, J., Bierings, R., Endeman, H., Goeijenbier, M., Hunfeld, N.G.M., van Gorp, E.C.M., Gommers, D.A.M.P.J., Koopmans, M.P.G., Kruip, M.J.H.A., Kuiken, T., Langerak, T., Leebeek, Lauw, M.N., de Maat, M.P.M., Noack, D., Paats, M.S., Raadsen, M.P., Rockx, B., Rokx, C., Schurink, C.A.M., Tong‐Minh, K., van den Toorn, L., den Uil, C.A., Visser, C., Boutkourt, F., Roest, T., Douma, R.A., de Haan, L.R., ten Wolde, M., Bemelmans, R.H.H., Festen, B., Stads, S., de Jager, C.P.C., Simons, K.S., Antoni, M.L., Bos, M.H., Burggraaf, J.L.I., Cannegieter, S.C., Eikenboom, H.C.J., den Exter, P.L., Geelhoed, J.J.M., Huisman, M.V., de Jonge, E., Kaptein, F.H.J., Klok, F.A., Kroft, L.J.M., Lijfering, W.M., Nab, L., Ninaber, M.K., Putter, H., Ramai, S.R.S., da Rocha Rondon, A.M., Roukens, A.H.E., Stals, M.A.M., Versteeg, H.H., Vliegen, H.W., van Vlijmen, B.J.M., van de Berg, T., Bruggemann, R., van Bussel, B.C.T., ten Cate, H., ten Cate‐Hoek, A., Hackeng, T.M., Henskens, ir.Y., Hulshof, A., Mulder, M., Olie, R.H., Schurgers, L., Spaetgens, B., Spronk, H., Winckers, K., Nieuwenhuizen, L., Franken, B., Schrover, I.M., de Waal, E.G.M., Beishuizen, A., Cornet, A., Krabbe, J., Kramers, K., Leentjens, J., de Mast, Q., Middeldorp, S., Brouwer, R.E., Ellerbroek, J.L.J., Tijmensen, J., Hovens, M.M C., Oostdijk, E.A.N., Westerhof, B.D., Faber, L.M., van den Biggelaar, M., Meijers, J.C.M., Voorberg, J., Kevenaar, M.E., Soei, Y.L., Wils, E.J., Croles, F.N., de Laat, B., Kamphuisen, P.W., Vink, R., Lisman, T., Meijer, K., van Tichelaar, Y.I.G., Cremer, O.L., Geersing, G., Kaasjager, H.A.H., Kusadasi, N., Huisman, A., Maas, C., Nijkeuter, M., Schutgens, R.E.G., Creveldkliniek, Van, Urbanus, R.T., Westerink, J., Faber, H.J., Koster, S.C.E., van Montfort, P., and van Twist, D.J.L.

Published
2022
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2. Chronic thromboembolic pulmonary hypertension and clot resolution after COVID-19-associated pulmonary embolism.

Author

Jong, C.M.M. de, Visser, Chantal, Bemelmans, R.H.H., Boersma, W.G., Borst, B. van den, Burggraaf, J.L., Cannegieter, S.C., Cate-Hoek, A.J. Ten, Croles, F.N., Faber, H.J., Faber, L.M., Hellemons, M.E., Hessels, L.M., Huisman, M.V., Kamphuisen, P.W., Koster, S.C.E., Kroft, L.J., Lee, I. van der, Leentjens, J., Meijer, K, Ninaber, M.K., Sondermeijer, B.M., Stads, S., Vonk Noordegraaf, A., Winckers, K., Kruip, M.J.H.A., Klok, F.A., Jong, C.M.M. de, Visser, Chantal, Bemelmans, R.H.H., Boersma, W.G., Borst, B. van den, Burggraaf, J.L., Cannegieter, S.C., Cate-Hoek, A.J. Ten, Croles, F.N., Faber, H.J., Faber, L.M., Hellemons, M.E., Hessels, L.M., Huisman, M.V., Kamphuisen, P.W., Koster, S.C.E., Kroft, L.J., Lee, I. van der, Leentjens, J., Meijer, K, Ninaber, M.K., Sondermeijer, B.M., Stads, S., Vonk Noordegraaf, A., Winckers, K., Kruip, M.J.H.A., and Klok, F.A.

Abstract

01 april 2023, Item does not contain fulltext, The results of this study suggest that CTEPH is not a more common long-term complication after COVID-19-associated PE than after PE in non-COVID-19 patients, and thrombus resolution did not seem to be different from non-COVID-19-associated PE https://bit.ly/3IjvWL3

Published
2023

3. Screening for venous thromboembolism in COVID-19 patients on the intensive care unit

Author

Melchers, M., van Zanten, A.R.H., Bemelmans, R.H.H., van Bree, S.H.W., Melchers, M., van Zanten, A.R.H., Bemelmans, R.H.H., and van Bree, S.H.W.

Abstract

Thromboembolic complications are frequently encountered in patients with severe COVID-19 disease in the intensive care unit (ICU). We assessed the prevalence of venous thromboembolism (VTE) in critically ill COVID-19 patients treated with dexamethasone and intensified thrombosis prophylaxis. To detect VTE, venous duplex ultrasonography was performed on day one and six of ICU admission, in addition to thoracic computed tomography angiography at ICU admission. Data from 57 consecutive patients were analysed and in 24 (42%) patients we detected a VTE. D-dimer levels were not useful to distinguish between patients with or without VTE; however, highly elevated D-dimer may indicate the presence of VTE. We report a high prevalence of VTE in critically ill COVID-19 patients despite intensified thrombosis prophylaxis and dexamethasone.

Published
2022

4. Ruling out Pulmonary Embolism in Patients with (Suspected) COVID-19-A Prospective Cohort Study

Author

Stals, M.A.M., Kaptein, F.H.J., Bemelmans, R.H.H., Bemmel, T. van, Boukema, I.C., Braeken, D.C.W., Braken, S.J.E., Bresser, C., Cate, H.T., Deenstra, D.D., Dooren, Y., Faber, L.M., Grootenboers, M., Haan, L.R., Haazer, C., Sol, A.I.D., Kelliher, S., Koster, T., Kroft, L.J., Meijer, R.I., Pals, F., Thiel, E.R.E. van, Westerweel, P.E., Wolde, M.T., Klok, F.A., Huisman, M.V., Stals, M.A.M., Kaptein, F.H.J., Bemelmans, R.H.H., Bemmel, T. van, Boukema, I.C., Braeken, D.C.W., Braken, S.J.E., Bresser, C., Cate, H.T., Deenstra, D.D., Dooren, Y., Faber, L.M., Grootenboers, M., Haan, L.R., Haazer, C., Sol, A.I.D., Kelliher, S., Koster, T., Kroft, L.J., Meijer, R.I., Pals, F., Thiel, E.R.E. van, Westerweel, P.E., Wolde, M.T., Klok, F.A., and Huisman, M.V.

Abstract

Item does not contain fulltext, Background Diagnostic strategies for suspected pulmonary embolism (PE) have not been prospectively evaluated in COVID-19 patients. Methods Prospective, multicenter, outcome study in 707 patients with both (suspected) COVID-19 and suspected PE in 14 hospitals. Patients on chronic anticoagulant therapy were excluded. Informed consent was obtained by opt-out approach. Patients were managed by validated diagnostic strategies for suspected PE. We evaluated the safety (3-month failure rate) and efficiency (number of computed tomography pulmonary angiographies [CTPAs] avoided) of the applied strategies. Results Overall PE prevalence was 28%. YEARS was applied in 36%, Wells rule in 4.2%, and "CTPA only" in 52%; 7.4% was not tested because of hemodynamic or respiratory instability. Within YEARS, PE was considered excluded without CTPA in 29%, of which one patient developed nonfatal PE during follow-up (failure rate 1.4%, 95% CI 0.04-7.8). One-hundred seventeen patients (46%) managed according to YEARS had a negative CTPA, of whom 10 were diagnosed with nonfatal venous thromboembolism (VTE) during follow-up (failure rate 8.8%, 95% CI 4.3-16). In patients managed by CTPA only, 66% had an initial negative CTPA, of whom eight patients were diagnosed with a nonfatal VTE during follow-up (failure rate 3.6%, 95% CI 1.6-7.0). Conclusion Our results underline the applicability of YEARS in (suspected) COVID-19 patients with suspected PE. CTPA could be avoided in 29% of patients managed by YEARS, with a low failure rate. The failure rate after a negative CTPA, used as a sole test or within YEARS, was non-negligible and reflects the high thrombotic risk in these patients, warranting ongoing vigilance.

Published
2021

7. The effect of physical exercise and resting heart rate on cardiovascular risk

Author

Bemelmans, R.H.H., Visseren, Frank, van der Graaf, Y, Spiering, Wilko, Wassink, A.M.J., and University Utrecht

Subjects
Econometric and Statistical Methods: General, Bescherming en bevordering van de menselijke gezondheid, Geneeskunde(GENK), Medical sciences, General [Econometric and Statistical Methods]
Abstract

The number of people conducting exercise in a natural environment, such as walking parts of an ancient pilgrimage, is increasing, justifying scientific research to its health effects. Walking part of the pilgrimage route to Santiago de Compostela in Spain, consisting of 280 km in 12 days, resulted in a sustained weight loss of around 2 kg, but no other beneficial metabolic of vascular effects persisting for at least 2 months after the pilgrimage. However, during the pilgrimage, there was a large, steady decrease in LDL-cholesterol (LDL-c), reaching a maximal decrease on day 10 of 1.1±0.7 mmol/l (-29%) compared to study baseline. Furthermore, male and female participants walking this pilgrimage with higher speed showed a larger increase in HDL-cholesterol (HDL-c), but a smaller decrease in LDL-c and total cholesterol than the participants walking with lower speed, and a higher walking speed was independently related to a higher increase in HDL-c and a lesser decrease in LDL-c. The underlying mechanisms of these changes in serum lipids were not investigated, but consumption of cholesterol for cellular metabolism and repair due to muscle damage seems the most likely explanation. Patients with the metabolic syndrome, participating in a nurse-led lifestyle modification program aiming at increasing physical activity and changing dietary habits, reached a average body weight loss of 2,5% (-2.3 kg. 95%CI -3.8--0.8) after 1 year. Both the amount of baseline physical activity and the change in physical activity during the study, were independently related to beneficial changes in parameters of body weight and insulin resistance. The effects of changes in physical activity on measures of body weight and insulin resistance are small, but increasing physical activity remains a cornerstone in the first step treatment of the metabolic syndrome. In the present thesis we present arguments for obesity and insulin resistance as both causes and consequences of sympathetic nerve activation. We show that typically ultrasonographically measured visceral adipose tissue thickness is independently related to increased resting heart rate in men and, to a smaller extent, in women, even after adjustment for body mass index. Furthermore we show that there is an independent relation between resting heart rate and incident type 2 diabetes mellitus (DM) during follow-up in patients with clinically manifest vascular disease. Resting heart rate has been accepted as a risk factor for premature mortality in patients with heart disease, and heart rate reduction is important in the treatment of these patients. In the present thesis we show that an increase in resting heart rate of 10 beats/minute is independently related to an increase in all-cause mortality of 14% (95%CI 7-21%), in vascular mortality of 15% (95%CI 6-25%) and in incident type 2 diabetes of 10% (95%CI 0-21%), in patients with clinically manifest vascular diseases, irrespective of the location. Therefore, we suggest that measurement and evaluation of resting heart rate should become routine practice in the management of patients with clinically manifest vascular diseases and the effect of heart rate reduction therapy in these patients should be investigated.

Published
2012

9. The effect of physical exercise and resting heart rate on cardiovascular risk

Author

Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Infectieziekten, Visseren, FLJ, van der Graaf, Yolanda, Spiering, Wilko, Wassink, A.M.J., Bemelmans, R.H.H., Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Infectieziekten, Visseren, FLJ, van der Graaf, Yolanda, Spiering, Wilko, Wassink, A.M.J., and Bemelmans, R.H.H.

Published
2012

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