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8 results on '"Belyaev, Grigory"'

3. Synthesis, Properties, and Biomedical Application of Dicationic Gemini Surfactants with Dodecane Spacer and Carbamate Fragments

Author

Vasileva, Leysan, primary, Gaynanova, Gulnara, additional, Valeeva, Farida, additional, Romanova, Elvira, additional, Pavlov, Rais, additional, Kuznetsov, Denis, additional, Belyaev, Grigory, additional, Zueva, Irina, additional, Lyubina, Anna, additional, Voloshina, Alexandra, additional, Petrov, Konstantin, additional, and Zakharova, Lucia, additional

Published
2023
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4. Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer’s Disease Therapy

Author

Vasileva, Leysan, primary, Gaynanova, Gulnara, additional, Valeeva, Farida, additional, Belyaev, Grigory, additional, Zueva, Irina, additional, Bushmeleva, Kseniya, additional, Sibgatullina, Guzel, additional, Samigullin, Dmitry, additional, Vyshtakalyuk, Alexandra, additional, Petrov, Konstantin, additional, Zakharova, Lucia, additional, and Sinyashin, Oleg, additional

Published
2023
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7. Conjugate of pyrimidine derivative, the drug xymedon with succinic acid protects liver cells.

Author

Vyshtakalyuk, Alexandra B., Parfenov, Andrey A., Gumarova, Lilya F., Khasanshina, Leyla R., Belyaev, Grigory P., Nazarov, Nail G., Kondrashina, Darya A., Galyametdinova, Irina V., Semenov, Vyacheslav E., and Zobov, Vladimir V.

Subjects
SUCCINIC acid, LIVER cells, PYRIMIDINE derivatives, LABORATORY rats, BIOMARKERS
Abstract

The aim of the study was to investigate the hepatoprotective properties of the conjugate of the xymedon drug substance with succinic acid (1a). The study presents an in vitro comparative evaluation of the cytotoxicity and cytoprotective properties of 1a and succinic acid on a cell line of normal human hepatocytes Chang Liver, and in vivo investigation of the ability of 1a to restore liver from the toxic damage caused by CCl4 in Wistar rats. It was shown that the cytotoxicity of 1a was 19.9 ± 0.8 mmol/L, and that of succinic acid was 14.1 ± 0.2 mmol/L. Against the background of d‐galactosamine exposure, the cytoprotective effect of 1a was found to be superior to that of succinic acid. It was shown that 1a caused a significant reduction in necrotic and steatosis changes in the liver and restoration of biochemical markers of cytolysis, as well as bilirubin metabolism and synthetic liver function. [ABSTRACT FROM AUTHOR]

Published
2021
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8. Angular momentum and energy spread measurements by backscattering technique

Author

Belyaev, Grigory

Subjects
TASK 7 [7]
Abstract

A main interest in the design of a high-intensity particle beam accelerator as the EURISOL driver is the control of the particle losses in the vacuum chamber. These losses, even concerning an extremely low fraction of the beam (10-4-10-7), can be sufficient to considerably complicate the maintenance of such an accelerator. Within this framework and in order to contribute to accelerator projects dedicated to rare isotope physics, the CEA is undertaking a research program on the theoretical and experimental study of the physical processes involved in halo formation around a high intensity beam in a particle accelerator. This research program is performed in collaboration with several French and international laboratories.This note details the principle and the design of an innovative emittance measurement unit which aims to be “weakly” interceptive. “Weakly” means that the beam can continue to propagate in the pipe with similar properties compared to the case when the diagnostic is not inserted. It is planned to compare these emittance measurements to the predictions of the home-made codes which are used to simulate the EURISOL medium and high energy sections.

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