224 results on '"Belmar J"'
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2. O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
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Yi Zhang, Shuyan Zhou, Yan Kai, Ya-qin Zhang, Changmin Peng, Zhuqing Li, Muhammad Jameel mughal, Belmar Julie, Xiaoyan Zheng, Junfeng Ma, Cynthia X. Ma, Min Shen, Matthew D. Hall, Shunqiang Li, and Wenge Zhu
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Science - Abstract
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings. Using high-throughput combinatorial drug screening and genomic sequencing, we find that the microphthalmia-associated transcription factor (MITF) is activated via O-GlcNAcylation by O-GlcNAc transferase (OGT) in palbociclib-resistant breast cancer cells and tumors. Mechanistically, O-GlcNAcylation of MITF at Serine 49 enhances its interaction with importin α/β, thus promoting its translocation to nuclei, where it suppresses palbociclib-induced senescence. Inhibition of MITF or its O-GlcNAcylation re-sensitizes resistant cells to palbociclib. Moreover, clinical studies confirm the activation of MITF in tumors from patients who are palbociclib-resistant or undergoing palbociclib treatment. Collectively, our studies shed light on the mechanism regulating palbociclib resistance and present clinical evidence for developing therapeutic approaches to treat CDK4/6i-resistant breast cancer patients.
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- 2024
- Full Text
- View/download PDF
3. EL DIAGNÓSTICO PRENATAL DE CARDIOPATÍAS CONGÉNITAS MEJORA EL PRONÓSTICO NEONATAL
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Lorena Quiroz V, Enrique Siebald C, Cristian Belmar J, Gonzalo Urcelay M, and Jorge Carvajal C
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Cardiopatías congénitas mayores ,diagnóstico prenatal ,ecocardiografía fetal ,Major congenital heart defects ,prenatal diagnosis ,fetal echocardiography ,Gynecology and obstetrics ,RG1-991 - Abstract
Las malformaciones congénitas son la principal causa de muerte neonatal precoz en nuestro medio; en la mayoría de los casos corresponden a cardiopatías congénitas mayores. Las cardiopatías congénitas tienen una incidencia de 8/1.000 recién nacidos vivos, correspondiendo la mitad de ellas a cardiopatías congénitas mayores. Una de las intervenciones recomendadas para reducir la mortalidad de este grupo de niños es evaluar rutinariamente la anatomía del corazón fetal mediante ecografía obstétrica, para planificar la atención neonatal, de aquellos fetos con cardiopatías congénitas, en el momento y lugar más oportuno. En objetivo de la presente revisión es comprobar si el diagnóstico prenatal de una cardiopatía congénita mejora el pronóstico perinatal respecto de aquellos casos que son diagnosticados post parto. Observamos que el diagnóstico antenatal de cardiopatía congénita, no mejora la sobrevida neonatal, excepto en ciertas cardiopatías congénitas ductus dependientes (transposición de grandes arterias, hipoplasia del corazón izquierdo y coartación de aorta), en que si se ha reportado una mayor probabilidad de sobrevida en el grupo de recién nacidos en los cuales se realizó el diagnóstico en el período prenatal. Recomendamos la evaluación rutinaria del corazón fetal en la ecografía obstétrica habitual, y efectuar ecocardiografía fetal especializada ante la sospecha de alteraciones o en aquellos grupos de mayor riesgoCongenital malformations are the main cause of neonatal death; in most of the cases they correspond to major congenital heart defects. Congenital heart defects have an incidence of 8/1,000 live newborns, corresponding half of them to major congenital heart defects. To reduce the mortality of this group of children routine evaluation of fetal heart anatomy by ultrasound is recommended, allowing neonatal care, of those fetuses with congenital heart defects, at the appropriate time and place. Here we attempt to verify if prenatal diagnosis of a congenital heart defect improves the perinatal outcome compare to postnatal diagnosis. We observed that the prenatal diagnosis of congenital heart defects, does not improve the neonatal outcome, except in certain congenital ductus dependent heart defects (transposition of great vessels, hypoplastic left heart syndrome and aortic coarctation), where a better outcome has been shown for those new born with prenatal diagnosis. We recommend routine evaluation of the fetal heart during prenatal ultrasound, and to carry out fetal echocardiography in high risk groups or when a defect is suspected
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- 2006
4. INCIDENCIA DE DIABETES GESTACIONAL SEGÚN DISTINTOS MéTODOS DIAGNóSTICOS Y SUS IMPLICANCIAS CLíNICAS
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Cristián Belmar J, Pablo Salinas C, Jorge Becker V, Fernando Abarzúa C, Pablo Olmos C, Pedro González B, and Enrique Oyarzún E
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Diabetes gestacional ,diagnóstico ,pronóstico ,Gestational diabetes ,diagnosis ,outcome ,Gynecology and obstetrics ,RG1-991 - Abstract
La incidencia de diabetes gestacional varía notablemente según el origen étnico del grupo evaluado. Se discute la necesidad de realizar screening en el embarazo y el método a utilizar. Este estudio compara dos grupos de 4.944 y 2.385 embarazadas que en periodos distintos, fueron sometidas a screening para diabetes gestacional. El primero según el esquema propuesto por la American Diabetes Association (ADA) y el segundo por la Organización Mundial de la Salud (OMS) y adoptado por el Ministerio de Salud de Chile (MINSAL) en 1998. Se observó que la incidencia de diabetes gestacional en el grupo según criterio ADA fue de 3,18%, mientras que en el grupo según criterio OMS fue de 7,72%. Asimismo, la incidencia de complicaciones asociadas a diabetes gestacional, tales como, fetos grandes para la edad gestacional, hipoglicemia neonatal e hipertensión del embarazo, fueron más frecuentes en diabéticas gestacionales según criterio ADA que en aquellas según criterio OMS. En contraste, no se observo diferencia entre ambos grupos en lo relativo a traumatismo obstétrico, asfixia neonatal y tasas de cesáreaThe incidence of gestational diabetes has a wide range from each ethnic group to another. In the latest years has been controversy about the convenience of make screening test for gestational diabetes and about the best test to do it. The present report compares two groups of 4944 and 2385 patients, who were tested for gestational diabetes at different times. The first group was tested with American Diabetes Association (ADA) method and the other group with World Health Organization (WHO) method, this one was adopted by National Health Ministry of Chile in 1998. The incidence of gestational diabetes was 3.18% in the group tested by ADA method in contrast to 7.72% in the group tested by WHO method. Therefore, the incidence of complications associated with gestacional diabetes, such as, birth weight above the 90th percentile, hypoglycemia and hypertension induced by pregnancy, were more frequent in diabetic patients from ADA method than WHO method. In contrast to this, there were not differences between both groups related to obstetric traumatism, neonatal asphyxia and cesarean rates
- Published
- 2004
5. REEVALUACION DE LA SENSIBILIDAD ANTIMICROBIANA DE PATOGENOS URINARIOS EN EL EMBARAZO
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Fernando Abarzúa C., Claudia Zajer, Bernardita Donoso, Cristián Belmar J., Juan Pablo Riveros, Pedro González B., and Enrique Oyarzún E.
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Infección urinaria ,sensibilidad antibiótica ,Urinary infection ,antibiotic sensitivity ,Gynecology and obstetrics ,RG1-991 - Abstract
La infección urinaria es la patología infecciosa más frecuente en el embarazo. Puede producir graves consecuencias para la madre y el feto. El presente trabajo muestra la frecuencia de los distintos cuadros clínicos, agentes involucrados, antimicrobianos utilizados en el tratamiento, y sensibilidad de los agentes a dichas drogas, durante el período entre marzo y diciembre de 2001. Se comparan dichos resultados con lo publicado por nuestro centro en 1988. Destaca la disminución en la incidencia de pielonefritis aguda y la aparición en los microorganismos de resistencia significativa a la cefazolina en el último período.Urinary tract infection is the most common infectious disease during pregnancy with serious consequences for mother and fetus. The present report shows clinical presentation, bacterial agents involved, treatment used and antibacterial sensitivity, from march to december 2001, and compares this with our own report of 1988. Remarkable is a decrasing incidence of pyelonephritis in the last period and increasing bacterial resistance to cefazolina in the last period.
- Published
- 2002
6. ESTUDIO DE SENSIBILIDAD ANTIMICROBIANA DE 183 CEPAS DE STREPTOCOCCUS AGALACTIAE AISLADAS EN REGION VAGINO-PERINEAL DE EMBARAZADAS EN EL TERCER TRIMESTRE
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Cristián Belmar J., Fernando Abarzúa C., Jorge Beker V., Ana María Guzmán, Patricia García C., and Enrique Oyarzún E.
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Streptococcus grupo Beta ,antibióticos sensibilidad ,Group B Streptococcus ,antibiotic sensibilities ,Gynecology and obstetrics ,RG1-991 - Abstract
fluctúa entre 1 y 3 por 1000 recién nacidos vivos. Se han entregado pautas dirigidas a reducir las tasas de sepsis precoz con la administración de antibióticos intraparto. Se ha propuesto como antibiótico de primera elección la Penicilina o Ampicilina, y Clindamicina para pacientes alérgicos a las primeras, pero también se ha planteado el uso de Eritromicina o Cefazolina. Se estudia la sensibilidad a estas drogas, en 183 cepas de Streptococcus Grupo B, aisladas en 917 embarazadas, al final del tercer trimestre, en región vaginal y pStreptococcus agalactiae (Grupo B Streptococcus) is the main bacterial agent involved in neonatal sepsis of early onset (1 to 3/1000 live newborns). Has been given standards for reducing the rates of neonatal sepsis of early onset using antibiotics during labor. Has been proposed as the first choice Penicilin or Ampicilin and Clindamicin for allergic patients. Erythromycin and Cefazolin has been proposed to treat this patients. This report study sensibilities for this drugs in 183 Group B Streptococcus strains from vaginal and perianal region of 917 pregnant women during the last trimester
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- 2002
7. ROTURA UTERINA EN PACIENTES SIN CICATRIZ UTERINA
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Cristián Belmar J., José A. Poblete L., Fernando Abarzúa C., and Enrique Oyarzún E.
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Rotura uterina sin cicatriz previa ,Uterine rupture ,unscarred uterus ,Gynecology and obstetrics ,RG1-991 - Abstract
La rotura uterina se presenta habitualmente en pacientes con cicatriz de cesáreas previas, siendo la rotura de un útero sin cicatriz un fenómeno infrecuente, pero de graves consecuencias para la madre y el feto. Presentamos nuestra experiencia reciente, detallando el manejo y resultados maternos y fetales.Uterine ruptures is more common in women with previous cesarean deliveries, ruptures in unscarred uterus are unfrequent, but with serious consequences for the mother and fetus. This report shows our recent experience, and describes treatment, and maternal and fetal outcomes.
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- 2002
8. Massive Bone Marrow Carcinomatosis Presenting with Leukoerythroblastic Blood Reaction
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Ana Garzo, Verdu Belmar J, De Paz Fj, Tarin F, and Campos E
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Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Medicine ,General Medicine ,Bone marrow ,business - Abstract
We present a case of an extensive bone marrow infiltrate of poorly differentiated carcinoma, in a 19-year-old male with suspected progression of sinusal undifferentiated carcinoma, after several lines of treatment.
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- 2021
9. EMBARAZO POSTERIOR A LIGADURA DE ARTERIAS HIPOGASTRICAS
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Cristián Belmar J, María I. Barriga C, Pablo Salinas, and Jorge Brañes Y
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Ligadura arterias hipogástricas ,embarazo ,Hypogastric arteries ligation ,postpartum hemorrhage ,Gynecology and obstetrics ,RG1-991 - Abstract
El tratamiento de la metrorragia postparto contempla enfoques quirúrgicos conservadores para aquellas pacientes en quienes se desea conservar la fertilidad. En ellas la ligadura de arterias hipogástricas muestra buenos resultados en el control del sangrado, además ha mostrado éxito en lograr embarazos posteriores. Se presenta un caso clínico manejado por los autores y se analiza la literatura disponibleTreatment for postpartum hemorrhage had conservative approaches for patients that want to preserve fertility. In those patients hypogastric arteries ligations show good results and good prognosis for future pregnancies. This case report shows our experience and review of the literature
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- 2003
10. Multiparameter Flow Cytometry Identification of Neoplastic Subclones: A New Biomarker in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma
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Tarín F, López-Castaño F, García-Hernández C, Beneit P, Sarmiento H, Manresa P, Alda O, Villarrubia B, Blanes M, Bernabéu J, Amorós C, Sánchez-Sánchez S, Fernández-Miñano C, De Paz F, Verdú-Belmar J, Marco P, and Matutes E
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Flow cytometry ,Multiple myeloma ,MGUS ,Neoplastic subclones - Abstract
Multiparameter flow cytometry (MFC)-based clonality assessment is a powerful method of diagnosis and follow-up in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). However, the relevance of intraclonal heterogeneity in immunophenotypic studies remains poorly understood. The main objective of this work was to characterize the different immunophenotypic subclones in MGUS and MM patients and to investigate their correlation with disease stages. An 8-color MFC proto-col with 17 markers was used to identify the subclones within the neoplastic compartment of 56 MGUS subjects, 151 newly diagnosed MM patients, 30 MM subjects in complete remission with detectable minimal residual disease, and 36 relapsed/refractory MM patients. Two or more clusters were observed in >85% of MGUS subjects, 75% of stage I MM patients, and
- Published
- 2019
11. UTILITY OF TCR-V CLONAL SEQUENCE ANALYSIS BY FLOW CYTOMETRY IN THE SCREENING, CHARACTERIZATION AND FOLLOW-UP OF LYMPHOPROLIFERATIVE SYNDROMES T
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Rodriguez V, Arranz O, Castano F, Marin J, Sala M, Manresa M, Beneit P, Majano J, Bernabeu J, Blanes M, Cedeno T, Javier C, Sanchez S, Tahoces M, Belmar J, Suarez M, Minano C, Alda O, Vazquez C, Toledo J, Frances R, Pascual M, and Rodrigo F
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- 2018
12. Survey adaptation for bio-behavioural surveillance of HIV in Chilean female sex workers
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Caryajal, B, Stuardo, V, Manriquez, JM, Belmar, J, and Folch, C
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Técnica Delphi ,Sex workers ,Delphi technique ,Epidemiological surveillance ,population characteristics ,virus diseases ,VIH ,HIV ,Trabajo sexual ,Vigilancia epidemiológica - Abstract
Resumen Objetivo: Adaptar un cuestionario conductual para la vigilancia de segunda generación del VIH/sida en mujeres trabajadoras sexuales (MTS) de la Región Metropolitana, Chile. Métodos: Estudio cualitativo de validación de instrumento. Se validó un cuestionario español adaptado en Cataluña (España) mediante traducción y retrotraducción del instrumento original. La validación de contenido se realizó a través de un grupo Delphi modificado, constituido por expertos en MTS y VIH, representantes de los ámbitos comunitario, político e institucional. Se evaluaron aspectos relacionados con la aplicabilidad del instrumento en terreno, encuestando a MTS de la Región Metropolitana. Resultados: El cuestionario, escrito en español de España, fue satisfactoriamente adaptado al español de Chile. En el proceso de validación de contenido se logró definir las secciones que abordan el VIH en la población MTS. El cuestionario adaptado tiene un tiempo de aplicación de menos de 15 minutos, por lo que es utilizable en terreno. Las 61 mujeres encuestadas presentan características diversas, tanto en país de origen (todas eran latinoamericanas) como en nivel de estudios, lo que permitió captar potenciales problemas en su aplicación. Discusión: El cuestionario adaptado para Chile contiene todos los indicadores para MTS recomendados por ONUSIDA, así como los recomendados por el Familly Health International para la vigilancia bioconductual. El instrumento definitivo emerge como una herramienta para la vigilancia de segunda generación del VIH y otras infecciones de transmisión sexual en Chile, y como un aporte al abordaje de políticas preventivas en la población de MTS. Abstract Objective: To adapt a behavioural questionnaire for second-generation HIV/AIDS surveillance in female sex workers (FSWs) in the Metropolitan Region, Chile. Methods: Qualitative study of instruments validation. A Spanish instrument adapted in Catalonia was validated through a translation and back-translation of the original version. The content validity was determined through a modified Delphi method, via FSW and HIV experts representing community, political and institutional levels. Applicability aspects were determined by the application of the questionnaire to FSW in the Metropolitan Region. Results: The questionnaire, drafted in Spain, was successfully adapted to Chilean Spanish. The content validity process enabled sections to be created that address HIV in FSWs. The adapted questionnaire takes less than 15minutes to complete, which makes it usable in fieldwork. The 61 women surveyed came from different countries (all were Latin Americans) and had different educational levels; all this enabled potential applicability problems to be detected. Discussion: The adapted questionnaire for Chile contains all the UNAIDS indicators for FSWs, as well as the recommended indicators of Family Health International for bio-behavioural surveillance. Said questionnaire serves as a tool for second-generation HIV/other STD surveillance and further contributes to preventive policies in Chilean FSWs.
- Published
- 2017
13. Clonidine Early in Life: Effect on Brain Morphofunctional Disturbances Induced by Neonatal Malnutrition in the Rat
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Soto-Moyano, R., primary, Hernandez, A., additional, Perez, H., additional, Ruiz, S., additional, Galleguillos, X., additional, and Belmar, J., additional
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- 1991
- Full Text
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14. Comparativa entre el índice de Mitchell y el índice Paliar para predecir la mortalidad en nuestros pacientes institucionalizados
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Padilla, R., primary, Belmar, J., additional, Martinez, E., additional, and Garnica, A., additional
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- 2018
- Full Text
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15. Utilidad del índice Paliar para predecir la mortalidad en nuestros pacientes institucionalizados
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Padilla, R., primary, Belmar, J., additional, Martinez, E., additional, and Garnica, A., additional
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- 2018
- Full Text
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16. Perfil lipídico en mujeres embarazadas sanas de tres regiones de chile
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Dolores Busso P, Gabriel Mardones, Nicolás Mertens F, Sebastián Illanes L, Javier Caradeux B, Ian Niklitschek L, Attilio Rigotti R, José Andrés Poblete L, Denisse Goldenberg A, José L. Santos M., Claudio Vera P-G, Daniela Olivari U, Leoncio Fuentes V, Pablo Olmos C, Bárbara Samith C, Manuel Escalona O, Cristián Belmar J., and Ana M Acosta B
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embarazo ,Cholesterol ,HDL ,Obstetrics and Gynecology ,pregnancy ,Colesterol ,triglycerides ,fatty acids ,ácidos grasos ,triglicéridos - Abstract
Antecedentes: Los lípidos plasmáticos maternos durante el embarazo pueden influir en el crecimiento fetal, particularmente en pacientes con diabetes gestacional; estos lípidos cambian su concentración plasmática materna a lo largo de la gestación. Objetivo: Calcular tablas y curvas de lípidos normales según edad gestacional en una población de embarazadas chilenas. Método: Se midió el colesterol total (CT), colesterol LDL (LDL-C) triglicéridos (TG), Colesterol-HDL (HDL-C), y ácidos grasos no esterificados (NEFA), en 94 embarazadas sanas y jóvenes (
- Published
- 2014
17. [Listeria monocytogenes infection in pregnancy: experience of Pontificia Universidad Católica de Chile University Hospital]
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Demetrio, Larraín de la C, Fernando, Abarzúa C, Francisca de, Jourdan H, Paulina, Merino O, Cristián, Belmar J, and Patricia, García C
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Adult ,Adolescent ,Infant, Newborn ,Pregnancy Outcome ,Listeria monocytogenes ,Perinatal Care ,Young Adult ,Pregnancy ,Humans ,Female ,Listeriosis ,Chile ,Pregnancy Complications, Infectious ,Fetal Death ,Retrospective Studies - Abstract
Listeria monocytogenes is Gram-positive facultative intracellular pathogen often foodborne and found elsewhere. It is an uncommon cause of illness in the general population. However, it is an important cause of severe infection in neonates, pregnant women, elderly and immunosuppressed patients. Listeriosis has unique preference for pregnant women. Maternal listeriosis is a diagnostic challenge, and intrauterine infection can lead to severe complications such as amnionitis, preterm labor, spontaneous abortion, stillbirth and neonatal sepsis. From 2001 to 2005, 16 patients with L. monocytogenes were identified in this hospital; four (25%) were pregnant women. Clinical and laboratory findings are described. There were 3 preterm deliveries and 1 spontaneous second trimester abortion. Three women with listeriosis had no predisposing factors other than pregnancy. One patient was on immunosupressive drugs for ulcerative colitis. Fever was the most common symptom. Infected neonates were most commonly diagnosed with early-onset listeriosis (two cases) or fetal demise (one case). Pregnancy can be the only risk factor for listeriosis. Listeriosis should be considered during the evaluation of febrile syndrome in pregnancy as this condition can be the only risk factor. Blood and amniotic fluid cultures are useful diagnostic tests. Perinatal complications remains high.
- Published
- 2008
18. Infecciones por Listeria monocytogenes en mujeres embarazadas: experiencia del Hospital Clínico de la Pontificia Universidad Católica de Chile
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Cristián Belmar J., Francisca de Jourdan H, Patricia García C, Paulina Merino O, Demetrio Larraín de la C, and Fernando Abarzúa C
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education.field_of_study ,medicine.medical_specialty ,Pregnancy ,embarazo ,Neonatal sepsis ,business.industry ,Obstetrics ,Population ,Public Health, Environmental and Occupational Health ,meningitis ,Retrospective cohort study ,Abortion ,medicine.disease ,medicine.disease_cause ,Listeria monocytogenes ,Ulcerative colitis ,óbito fetal ,Infectious Diseases ,listeriosis ,medicine ,Risk factor ,education ,business - Abstract
Listeria monocytogenes is Gram-positive facultative intracellular pathogen often foodborne and found elsewhere. It is an uncommon cause of illness in the general population. However, it is an important cause of severe infection in neonates, pregnant women, elderly and immunosuppressed patients. Listeriosis has unique preference for pregnant women. Maternal listeriosis is a diagnostic challenge, and intrauterine infection can lead to severe complications such as amnionitis, preterm labor, spontaneous abortion, stillbirth and neonatal sepsis. From 2001 to 2005, 16 patients with L. monocytogenes were identified in this hospital; four (25%) were pregnant women. Clinical and laboratory findings are described. There were 3 preterm deliveries and 1 spontaneous second trimester abortion. Three women with listeriosis had no predisposing factors other than pregnancy. One patient was on immunosupressive drugs for ulcerative colitis. Fever was the most common symptom. Infected neonates were most commonly diagnosed with early-onset listeriosis (two cases) or fetal demise (one case). Pregnancy can be the only risk factor for listeriosis. Listeriosis should be considered during the evaluation of febrile syndrome in pregnancy as this condition can be the only risk factor. Blood and amniotic fluid cultures are useful diagnostic tests. Perinatal complications remains high.
- Published
- 2008
19. Infecciones por Listeria monocytogenes en mujeres embarazadas: experiencia del Hospital Clínico de la Pontificia Universidad Católica de Chile
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Larraín de la C, Demetrio, Abarzúa C, Fernando, de Jourdan H, Francisca, Merino O, Paulina, Belmar J, Cristián, and García C, Patricia
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embarazo ,óbito fetal ,listeriosis ,meningitis ,pregnaney ,Listeria monocytogenes ,fetal demise - Abstract
Listeria monocytogenes es un bacilo grampositivo, intracelular facultativo, que se encuentra ampliamente difundido en la naturaleza, frecuentemente en alimentos. Las infecciones afectan principalmente a pacientes inmunocomprometidos, ancianos, mujeres embarazadas y neonatos. La infección intrauterina puede producir importantes complicaciones como corioamnionitis, parto de pre-término, aborto espontáneo de primer o segundo trimestre, mortinatos y sepsis neonatal. En el período 2001-2005, 16 pacientes con infección por L. monocytogenes fueron identificados en nuestro hospital. Cuatro de ellos (25%) se presentaron en mujeres embarazadas; se describen sus características clínicas y de laboratorio. Hubo tres partos de pre-término y un aborto espontáneo de segundo trimestre. En tres de las cuatro pacientes, el único factor de riesgo fue el embarazo. Una paciente recibía terapia inmunosupresora por una colitis ulcerosa. Fiebre fue el síntoma más frecuente. El compromiso feto-neonatal se manifestó por listeriosis neonatal precoz (dos casos) y mortinato (un caso). El embarazo puede ser el único factor predisponente a desarrollar listeriosis. Ésta debe considerarse en la evaluación del síndrome febril de una mujer embarazada. Los cultivos de sangre y líquido amniótico son útiles para su diagnóstico. La tasa de complicaciones perinatales permanece elevada. Listeria monocytogenes is Gram-positive facultative intracellular pathogen often foodborne and found elsewhere. It is an uncommon cause of illness in the general population. However, it is an important cause of severe infection in neonates, pregnant women, elderly and immunosuppressed patients. Listeriosis has unique preference for pregnant women. Maternal listeriosis is a diagnostic challenge, and intrauterine infection can lead to severe complications such as amnionitis, preterm labor, spontaneous abortion, stillbirth and neonatal sepsis. From 2001 to 2005, 16 patients with L. monocytogenes were identified in this hospital; four (25%) were pregnant women. Clinical and laboratory findings are described. There were 3 preterm deliveries and 1 spontaneous second trimester abortion. Three women with listeriosis had no predisposing factors other than pregnaney. One patient was on immunosupressive drugs for ulcerative colitis. Fever was the most common symptom. Infected neonates were most commonly diagnosed with early-onset listeriosis (two cases) or fetal demise (one case). Pregnaney can be the only risk factor for listeriosis. Listeriosis should be considered during the evaluation of febrile syndrome in pregnaney as this condition can be the only risk factor. Blood and amniotic fluid cultures are useful diagnostic tests. Perinatal complications remains high.
- Published
- 2008
20. [Diagnosis of congenital syphilis at delivery: maternal serum or cord blood?]
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Fernando, Abarzúa C, Cristián, Belmar J, Alonso, Rioseco R, Jacqueline, Parada B, Teresa, Quiroga G, and Patricia, García C
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Adult ,Neonatal Screening ,Syphilis, Congenital ,Infant, Newborn ,Humans ,False Positive Reactions ,Female ,Prospective Studies ,Fetal Blood ,False Negative Reactions ,Sensitivity and Specificity ,Syphilis Serodiagnosis - Abstract
Congenital syphilis (CS) is an important health problem in Chile, with a rate of 0.25/1,000 live newborn (NB) during year 2004. In 2000, the Chilean Ministry of Public Health recommended to perform a screening in cord blood at the moment of delivery. Instead, the Centers for Disease Control and Prevention guidelines recommend the screening in maternal serum since cord blood has up to 5% of false (-) versus 0.5% of maternal serum, both with respect to the NB serum.Maternal serum and NB cord blood were studied during one year to determine the best screening method at delivery.RPR was performed and positive results were confirmed by treponemic test (immunochromatographyDetermine, ELISA Captia, Ig and IgM, and MHA-Tp). Serologically confirmed patients were evaluated by the specialist to define CS cases.Between June 1999 and August 2000 2,741 binomies were studied; of these, 37 (1.3%) were RPR reactive and 2.704 were non-reactive. In 11 of the 37 reactive cases, mother and NB were RPR reactive (Group I), in 9 cases the NB was RPR reactive and the mother was non-reactive (Group II), and the other 17 were NB non-reactive and mother reactive (Group III). In group I, 7/11 (64%) were true (+)s and 4/11(36%)) false (+)s of RPR. In group II, 9/9 (100%) corresponded to false (+)s of RPR in cord blood, and in group III, 11/17 (65%) corresponded to false (+)s of RPR in maternal blood but 6/17 (35%) were found to be cases of syphilis during pregnancy. Three of them were not treated opportunely and were designed as CS. In total 9 NB corresponded to CS (6 in group I and 3 in group III). If the screening had been performed only in cord blood, three NB with CS would have not been diagnosed.Even when maternal serum has a high rate of false (+)s, it has better sensitivity than cord blood for the diagnosis of CS, thus it is suggested to perform the screening at delivery with maternal serum instead of cord blood samples.
- Published
- 2008
21. Pesquisa de sífilis congénita al momento del parto: ¿Suero materno o sangre de cordón?
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Abarzúa C, Fernando, Belmar J, Cristián, Rioseco R, Alonso, Parada B, Jacqueline, Quiroga G, Teresa, and García C, Patricia
- Subjects
embarazo ,sífilis congénita ,sangre de cordón ,cord blood sampling ,Congenital syphilis ,pregnancy - Abstract
La sífilis congénita (SC) es un problema importante en Chile, con una tasa de 0,25/1.000 recién nacidos (RNs) vivos en el año 2004. En el año 2000, el Ministerio de Salud recomendaba como tamizaje al momento del parto una muestra de sangre de cordón. El Centro de Control y Prevención de Enfermedades, (CDC), Atlanta, E.U.A. recomendó, desde 1998, el tamizaje al parto con suero materno ya que respecto del suero del RN, la sangre de cordón y el suero materno tienen respectivamente hasta 5 y 0,5%> de falsos negativos. Objetivo: Determinar el mejor tamizaje al momento del parto. Métodos: Se estudiaron muestras de suero materno y sangre de cordón de los RNs durante un año. Se realizó RPR y de ser positiva, pruebas treponémicas confirmatorias (imunocromatográfico Determine®, ELISA Captia® IgG e IgM y microhemaglutinación). Todos los pacientes confirmados fueron vistos por el especialista para definir los casos de SC. Resultados: Entre junio de 1999 y agosto del 2000 se estudiaron 2.741 binomios madre-RN; de éstos 37/2.704 (1,3%) fueron RPR reactivos. Once eran RPR reactivo en la madre y en el RN (Grupo I), 9 eran RPR reactivo en el RN y no reactivo en la madre (Grupo II) y 17 eran RN con RPR no reactivo y reactivo en la madre (Grupo III). En el Grupo I hubo 64%> (7/11) de verdaderos (+)s y 36% (4/11) de falsos (+)s del RPR. En el Grupo II, 9/ 9 (100%o), correspondieron a falsos (+)s del RPR en sangre de cordón y en el Grupo III, 11/17 (67%>) correspondieron a falsos (+)s del RPR en sangre materna pero hubo 6/17 (35%>) que correspondían a sífilis durante el embarazo y en tres de ellas no hubo tratamiento intra-embarazo, por lo que fueron catalogadas como SC y los RNs debieron ser tratados. En total hubo 9 RNs que correspondieron a SC (6 del grupo I y 3 del grupo III). Si sólo se hubiese realizado tamizaje en sangre de cordón, 3 RNs con SC no se hubiesen diagnosticado. Conclusión: Si bien el suero materno tiene una tasa de falsos (+)s alta, tiene mejor sensibilidad que la sangre de cordón para el diagnóstico de SC; por lo que se sugiere realizar el tamizaje al momento del parto con suero materno en vez de sangre de cordón Congenital syphilis (CS) is an important health problem in Chile, with a rate of 0.25/1,000 live newborn (NB) during year 2004. In 2000, the Chilean Ministry of Public Health recommended to perform a screening in cord blood at the moment of delivery. Instead, the Centers for Disease Control and Prevention guidelines recommend the screening in maternal serum since cord blood has up to 5% of false (-) versus 0.5% of maternal serum, both with respect to the NB serum. Objective: Maternal serum and NB cord blood were studied during one year to determine the best screening method at delivery. Methods: RPR was performed and positive results were confirmed by treponemic test (immunochromatographyDetermine®, ELISA Captia®, Ig and IgM, and MHA-Tp). Serologically confirmed patients were evaluated by the specialist to define CS cases. Results: Between June 1999 and August 2000 2,741 binomies were studied; of these, 37 (1.3%) were RPR reactive and 2.704 were non-reactive. In 11 of the 37 reactive cases, mother and NB were RPR reactive (Group I), in 9 cases the NB was RPR reactive and the mother was non-reactive (Group II), and the other 17 were NB non-reactive and mother reactive (Group III). In group I, 7/11 (64%) were true (+)s and 4/11(36%)) false (+)s of RPR. In group II, 9/9 (100%) corresponded to false (+)s of RPR in cord blood, and in group III, 11/17 (65%) corresponded to false (+)s of RPR in maternal blood but 6/17 (35%) were found to be cases of syphilis during pregnancy. Three of them were not treated opportunely and were designed as CS. In total 9 NB corresponded to CS (6 in group I and 3 in group III). If the screening had been performed only in cord blood, three NB with CS would have not been diagnosed. Conclusion: Even when maternal serum has a high rate of false (+)s, it has better sensitivity than cord blood for the diagnosis of CS, thus it is suggested to perform the screening at delivery with maternal serum instead of cord blood samples
- Published
- 2008
22. Pesquisa de sífilis congénita al momento del parto: ¿Suero materno o sangre de cordón?
- Author
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Alonso Rioseco R, Cristián Belmar J., Teresa Quiroga G, Fernando Abarzúa C, Patricia García C, and Jacqueline Parada B
- Subjects
Gynecology ,medicine.medical_specialty ,Infectious Diseases ,embarazo ,business.industry ,Recien nacido ,Public Health, Environmental and Occupational Health ,medicine ,Recem nascido ,sífilis congénita ,sangre de cordón ,business - Abstract
La sifilis congenita (SC) es un problema importante en Chile, con una tasa de 0,25/1.000 recien nacidos (RNs) vivos en el ano 2004. En el ano 2000, el Ministerio de Salud recomendaba como tamizaje al momento del parto una muestra de sangre de cordon. El Centro de Control y Prevencion de Enfermedades, (CDC), Atlanta, E.U.A. recomendo, desde 1998, el tamizaje al parto con suero materno ya que respecto del suero del RN, la sangre de cordon y el suero materno tienen respectivamente hasta 5 y 0,5%> de falsos negativos. Objetivo: Determinar el mejor tamizaje al momento del parto. Metodos: Se estudiaron muestras de suero materno y sangre de cordon de los RNs durante un ano. Se realizo RPR y de ser positiva, pruebas treponemicas confirmatorias (imunocromatografico Determine®, ELISA Captia® IgG e IgM y microhemaglutinacion). Todos los pacientes confirmados fueron vistos por el especialista para definir los casos de SC. Resultados: Entre junio de 1999 y agosto del 2000 se estudiaron 2.741 binomios madre-RN; de estos 37/2.704 (1,3%) fueron RPR reactivos. Once eran RPR reactivo en la madre y en el RN (Grupo I), 9 eran RPR reactivo en el RN y no reactivo en la madre (Grupo II) y 17 eran RN con RPR no reactivo y reactivo en la madre (Grupo III). En el Grupo I hubo 64%> (7/11) de verdaderos (+)s y 36% (4/11) de falsos (+)s del RPR. En el Grupo II, 9/ 9 (100%o), correspondieron a falsos (+)s del RPR en sangre de cordon y en el Grupo III, 11/17 (67%>) correspondieron a falsos (+)s del RPR en sangre materna pero hubo 6/17 (35%>) que correspondian a sifilis durante el embarazo y en tres de ellas no hubo tratamiento intra-embarazo, por lo que fueron catalogadas como SC y los RNs debieron ser tratados. En total hubo 9 RNs que correspondieron a SC (6 del grupo I y 3 del grupo III). Si solo se hubiese realizado tamizaje en sangre de cordon, 3 RNs con SC no se hubiesen diagnosticado. Conclusion: Si bien el suero materno tiene una tasa de falsos (+)s alta, tiene mejor sensibilidad que la sangre de cordon para el diagnostico de SC; por lo que se sugiere realizar el tamizaje al momento del parto con suero materno en vez de sangre de cordon
- Published
- 2008
23. EFFECTS OF PROGESTERONE ON THE NORADRENERGIC SYSTEM OF RABBIT OVIDUCTS
- Author
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Belmar, J., primary, Lara, H., additional, Sainzt, J., additional, and Viveros, H., additional
- Published
- 1979
- Full Text
- View/download PDF
24. EL DIAGNÓSTICO PRENATAL DE CARDIOPATÍAS CONGÉNITAS MEJORA EL PRONÓSTICO NEONATAL
- Author
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Enrique Siebald C, Jorge Carvajal C, Gonzalo Urcelay M, Cristián Belmar J., and Lorena Quiroz V
- Subjects
Fetus ,Pediatrics ,medicine.medical_specialty ,prenatal diagnosis ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Cardiopatías congénitas mayores ,Obstetrics and Gynecology ,Perinatal outcome ,Prenatal diagnosis ,fetal echocardiography ,medicine.disease ,Hypoplastic left heart syndrome ,ecocardiografía fetal ,Major congenital heart defects ,Great vessels ,diagnóstico prenatal ,medicine ,Neonatal death ,business ,Fetal echocardiography - Abstract
Las malformaciones congénitas son la principal causa de muerte neonatal precoz en nuestro medio; en la mayoría de los casos corresponden a cardiopatías congénitas mayores. Las cardiopatías congénitas tienen una incidencia de 8/1.000 recién nacidos vivos, correspondiendo la mitad de ellas a cardiopatías congénitas mayores. Una de las intervenciones recomendadas para reducir la mortalidad de este grupo de niños es evaluar rutinariamente la anatomía del corazón fetal mediante ecografía obstétrica, para planificar la atención neonatal, de aquellos fetos con cardiopatías congénitas, en el momento y lugar más oportuno. En objetivo de la presente revisión es comprobar si el diagnóstico prenatal de una cardiopatía congénita mejora el pronóstico perinatal respecto de aquellos casos que son diagnosticados post parto. Observamos que el diagnóstico antenatal de cardiopatía congénita, no mejora la sobrevida neonatal, excepto en ciertas cardiopatías congénitas ductus dependientes (transposición de grandes arterias, hipoplasia del corazón izquierdo y coartación de aorta), en que si se ha reportado una mayor probabilidad de sobrevida en el grupo de recién nacidos en los cuales se realizó el diagnóstico en el período prenatal. Recomendamos la evaluación rutinaria del corazón fetal en la ecografía obstétrica habitual, y efectuar ecocardiografía fetal especializada ante la sospecha de alteraciones o en aquellos grupos de mayor riesgo Congenital malformations are the main cause of neonatal death; in most of the cases they correspond to major congenital heart defects. Congenital heart defects have an incidence of 8/1,000 live newborns, corresponding half of them to major congenital heart defects. To reduce the mortality of this group of children routine evaluation of fetal heart anatomy by ultrasound is recommended, allowing neonatal care, of those fetuses with congenital heart defects, at the appropriate time and place. Here we attempt to verify if prenatal diagnosis of a congenital heart defect improves the perinatal outcome compare to postnatal diagnosis. We observed that the prenatal diagnosis of congenital heart defects, does not improve the neonatal outcome, except in certain congenital ductus dependent heart defects (transposition of great vessels, hypoplastic left heart syndrome and aortic coarctation), where a better outcome has been shown for those new born with prenatal diagnosis. We recommend routine evaluation of the fetal heart during prenatal ultrasound, and to carry out fetal echocardiography in high risk groups or when a defect is suspected
- Published
- 2006
25. INCIDENCIA DE DIABETES GESTACIONAL SEGÚN DISTINTOS MéTODOS DIAGNóSTICOS Y SUS IMPLICANCIAS CLíNICAS
- Author
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Fernando Abarzúa C, Pedro González B., Cristián Belmar J., Pablo Olmos C, Pablo Salinas C, Enrique Oyarzún E, and Jorge Becker
- Subjects
Asphyxia ,Diabetes gestacional ,Percentile ,medicine.medical_specialty ,Pregnancy ,diagnosis ,Obstetrics ,business.industry ,Birth weight ,Incidence (epidemiology) ,Obstetrics and Gynecology ,Hypoglycemia ,medicine.disease ,Surgery ,diagnóstico ,Gestational diabetes ,pronóstico ,Diabetes mellitus ,outcome ,medicine ,medicine.symptom ,business - Abstract
La incidencia de diabetes gestacional varía notablemente según el origen étnico del grupo evaluado. Se discute la necesidad de realizar screening en el embarazo y el método a utilizar. Este estudio compara dos grupos de 4.944 y 2.385 embarazadas que en periodos distintos, fueron sometidas a screening para diabetes gestacional. El primero según el esquema propuesto por la American Diabetes Association (ADA) y el segundo por la Organización Mundial de la Salud (OMS) y adoptado por el Ministerio de Salud de Chile (MINSAL) en 1998. Se observó que la incidencia de diabetes gestacional en el grupo según criterio ADA fue de 3,18%, mientras que en el grupo según criterio OMS fue de 7,72%. Asimismo, la incidencia de complicaciones asociadas a diabetes gestacional, tales como, fetos grandes para la edad gestacional, hipoglicemia neonatal e hipertensión del embarazo, fueron más frecuentes en diabéticas gestacionales según criterio ADA que en aquellas según criterio OMS. En contraste, no se observo diferencia entre ambos grupos en lo relativo a traumatismo obstétrico, asfixia neonatal y tasas de cesárea The incidence of gestational diabetes has a wide range from each ethnic group to another. In the latest years has been controversy about the convenience of make screening test for gestational diabetes and about the best test to do it. The present report compares two groups of 4944 and 2385 patients, who were tested for gestational diabetes at different times. The first group was tested with American Diabetes Association (ADA) method and the other group with World Health Organization (WHO) method, this one was adopted by National Health Ministry of Chile in 1998. The incidence of gestational diabetes was 3.18% in the group tested by ADA method in contrast to 7.72% in the group tested by WHO method. Therefore, the incidence of complications associated with gestacional diabetes, such as, birth weight above the 90th percentile, hypoglycemia and hypertension induced by pregnancy, were more frequent in diabetic patients from ADA method than WHO method. In contrast to this, there were not differences between both groups related to obstetric traumatism, neonatal asphyxia and cesarean rates
- Published
- 2004
26. Perfil lipídico en mujeres embarazadas sanas de tres regiones de Chile
- Author
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Olmos C, Pablo, primary, Escalona O, Manuel, additional, Illanes L, Sebastián, additional, Caradeux B, Javier, additional, Mardones, Gabriel, additional, Olivari U, Daniela, additional, Fuentes V, Leoncio, additional, Acosta B, Ana, additional, Rigotti R, Attilio, additional, Busso P, Dolores, additional, Santos M, José, additional, Poblete L, José, additional, Vera P-G, Claudio, additional, Belmar J, Cristián, additional, Goldenberg A, Denisse, additional, Samith C, Bárbara, additional, Niklitschek L, Ian, additional, and Mertens F, Nicolás, additional
- Published
- 2014
- Full Text
- View/download PDF
27. Synthesis and Characterization of Phenylene-bis-pyrazolones and Nitrosation Derivatives
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Belmar, J., primary, Ortiz, L., additional, Quezada, J., additional, Parra, M., additional, and Jiménez, C. A., additional
- Published
- 2014
- Full Text
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28. EMBARAZO POSTERIOR A LIGADURA DE ARTERIAS HIPOGASTRICAS
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Pablo Herrera Salinas, María I. Barriga C, Cristián Belmar J., and Jorge Brañes Y
- Subjects
Ligadura arterias hipogástricas ,embarazo ,Obstetrics and Gynecology - Abstract
El tratamiento de la metrorragia postparto contempla enfoques quirúrgicos conservadores para aquellas pacientes en quienes se desea conservar la fertilidad. En ellas la ligadura de arterias hipogástricas muestra buenos resultados en el control del sangrado, además ha mostrado éxito en lograr embarazos posteriores. Se presenta un caso clínico manejado por los autores y se analiza la literatura disponible
- Published
- 2003
29. EMBARAZO POSTERIOR A LIGADURA DE ARTERIAS HIPOGASTRICAS
- Author
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Belmar J, Cristián, Barriga C, María I., Salinas, Pablo, and Brañes Y, Jorge
- Subjects
Ligadura arterias hipogástricas ,embarazo ,postpartum hemorrhage ,Hypogastric arteries ligation - Abstract
El tratamiento de la metrorragia postparto contempla enfoques quirúrgicos conservadores para aquellas pacientes en quienes se desea conservar la fertilidad. En ellas la ligadura de arterias hipogástricas muestra buenos resultados en el control del sangrado, además ha mostrado éxito en lograr embarazos posteriores. Se presenta un caso clínico manejado por los autores y se analiza la literatura disponible Treatment for postpartum hemorrhage had conservative approaches for patients that want to preserve fertility. In those patients hypogastric arteries ligations show good results and good prognosis for future pregnancies. This case report shows our experience and review of the literature
- Published
- 2003
30. ESTUDIO DE SENSIBILIDAD ANTIMICROBIANA DE 183 CEPAS DE STREPTOCOCCUS AGALACTIAE AISLADAS EN REGION VAGINO-PERINEAL DE EMBARAZADAS EN EL TERCER TRIMESTRE
- Author
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Fernando Abarzúa C, Ana María Guzmán, Patricia García C, Enrique Oyarzún E, Jorge Beker V., and Cristián Belmar J.
- Subjects
Group B Streptococcus ,Clindamicin ,Gynecology ,medicine.medical_specialty ,antibiotic sensibilities ,Report study ,Streptococcus ,business.industry ,Obstetrics and Gynecology ,medicine.disease_cause ,antibióticos sensibilidad ,Group B ,Surgery ,Recien nacido ,medicine ,Bacterial agent ,business ,Streptococcus grupo Beta ,Early onset - Abstract
RESUMENStreptococcus agalactiae es el principal agente causal de sepsis neonatal de aparicion precoz con unaincidencia que fluctua entre 1 y 3 por 1000 recien nacidos vivos. Se han entregado pautas dirigidas a reducirlas tasas de sepsis precoz con la administracion de antibioticos intraparto. Se ha propuesto como antibioticode primera eleccion la Penicilina o Ampicilina, y Clindamicina para pacientes alergicos a las primeras, perotambien se ha planteado el uso de Eritromicina o Cefazolina. Se estudia la sensibilidad a estas drogas, en183 cepas de Streptococcus Grupo B, aisladas en 917 embarazadas, al final del tercer trimestre, en regionvaginal y perianal.PALABRAS CLAVES: Streptococcus grupo Beta, antibioticos sensibilidadSUMMARYStreptococcus agalactiae (Grupo B Streptococcus) is the main bacterial agent involved in neonatalsepsis of early onset (1 to 3/1000 live newborns). Has been given standards for reducing the rates ofneonatal sepsis of early onset using antibiotics during labor. Has been proposed as the first choice Penicilinor Ampicilin and Clindamicin for allergic patients. Erythromycin and Cefazolin has been proposed to treatthis patients.This report study sensibilities for this drugs in 183 Group B Streptococcus strains from vaginal andperianal region of 917 pregnant women during the last trimester.KEY WORDS: Group B Streptococcus, antibiotic sensibilities
- Published
- 2002
31. ROTURA UTERINA EN PACIENTES SIN CICATRIZ UTERINA
- Author
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Enrique Oyarzún E, Cristián Belmar J., José Andrés Poblete L, and Fernando Abarzúa C
- Subjects
Fetus ,medicine.medical_specialty ,Previous cesarean ,business.industry ,Obstetrics ,Rotura uterina sin cicatriz previa ,Obstetrics and Gynecology ,Uterine rupture ,embryonic structures ,Medicine ,unscarred uterus ,business ,Unscarred uterus ,reproductive and urinary physiology - Abstract
La rotura uterina se presenta habitualmente en pacientes con cicatriz de cesáreas previas, siendo la rotura de un útero sin cicatriz un fenómeno infrecuente, pero de graves consecuencias para la madre y el feto. Presentamos nuestra experiencia reciente, detallando el manejo y resultados maternos y fetales. Uterine ruptures is more common in women with previous cesarean deliveries, ruptures in unscarred uterus are unfrequent, but with serious consequences for the mother and fetus. This report shows our recent experience, and describes treatment, and maternal and fetal outcomes.
- Published
- 2002
32. REEVALUACION DE LA SENSIBILIDAD ANTIMICROBIANA DE PATOGENOS URINARIOS EN EL EMBARAZO
- Author
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Claudia Zajer, Enrique Oyarzún E, Fernando Abarzúa C, Cristián Belmar J., Juan Pablo Riveros, Pedro González B., and Bernardita Donoso
- Subjects
Obstetrics and Gynecology ,sensibilidad antibiótica ,Infección urinaria ,antibiotic sensitivity ,Urinary infection - Abstract
RESUMENLa infeccion urinaria es la patologia infecciosa mas frecuente en el embarazo. Puede producir gravesconsecuencias para la madre y el feto.El presente trabajo muestra la frecuencia de los distintos cuadros clinicos, agentes involucrados,antimicrobianos utilizados en el tratamiento, y sensibilidad de los agentes a dichas drogas, durante elperiodo entre marzo y diciembre de 2001. Se comparan dichos resultados con lo publicado por nuestrocentro en 1988.Destaca la disminucion en la incidencia de pielonefritis aguda y la aparicion en los microorganismos deresistencia significativa a la cefazolina en el ultimo periodo.PALABRAS CLAVES: Infeccion urinaria, sensibilidad antibioticaSUMMARYUrinary tract infection is the most common infectious disease during pregnancy with serious conse-quences for mother and fetus.The present report shows clinical presentation, bacterial agents involved, treatment used and antibac-terial sensitivity, from march to december 2001, and compares this with our own report of 1988.Remarkable is a decrasing incidence of pyelonephritis in the last period and increasing bacterialresistance to cefazolina in the last period.KEY WORDS: Urinary infection, antibiotic sensitivity
- Published
- 2002
33. Resultados de la aplicación del protocolo basado en screening para la búsqueda de Streptococcus agalactiae en el tercer trimestre del embarazo: Posible impacto sobre la sepsis neonatal precoz por este agente
- Author
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Ana María Guzmán D, Patricia García C, Cristián Belmar J., and Fernando Abarzúa C
- Subjects
Infectious Diseases ,Neonatal sepsis ,Public Health, Environmental and Occupational Health ,Streptococcus agalactiae - Abstract
Streptococcus agalactiae (SGB) es la principal causa de sepsis neonatal precoz (SNP). Recientemente el CDC ha planteado tratar sólo pacientes con factores de riesgo o detectar a las portadoras realizando cultivo vaginal-perianal en el 3º trimestre del embarazo (screening universal). En nuestro hospital hasta el año 1999 sólo se trataba a las pacientes con factores de riesgo, presentando en el bienio 1997/1998 una tasa de SNP por SGB de 1,84/1.000 nacidos vivos. Entre octubre 1999 y noviembre 2000 se aplicó screening universal encontrándose 20% de portadoras. En el período de estudio hubo dos casos de SNP por SGB: un prematuro y un R.N. de término sin factor de riesgo a cuya madre no se le tomó cultivo. La incidencia del período fue de 0,73/1.000 R.N. vivos, lo que indica una disminución de 61% con respecto al período previo. Group B streptococcal infection is the most important cause of neonatal sepsis. The CDC has proposed two alternative strategies for its control: antibiotic treatment only of pregnant women with risk factors or antibiotic treatment of identified group B streptococcal carriers after culturing all pregnant women. At our institution until 1999 we only treated women with risk factors. The incidence of group B streptococcal sepsis in 1997/1998 was 1.84/1.000 per 1.000 live births. Between October 1999 and November 2000 we established universal screening. Maternal GBS carriage rate was 20%. Two newborn infants acquired group B streptococcal sepsis: one premature newborn and one on term newborn infant of a mother without screening. The successful implementation and manteinance of a screening protocol reduced neonatal group B streptococcal sepsis in a 61% rate with an incidence of 0.73/1.000 live births.
- Published
- 2001
34. SYNTHESIS AND CHARACTERIZATION OF BIS- AND TOS-(4-CARBOXYBENZOYL)-ALKANEAMINES
- Author
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GUARDA, L, primary, PARRA, N, additional, CHAVEZ, M. S, additional, BELMAR, J, additional, JIMENEZ, C. A, additional, PASAN, J, additional, and RUIZ-PEREZ, C, additional
- Published
- 2012
- Full Text
- View/download PDF
35. CQA-WF: Consistent Query Answers to Conjunctive Queries Using the Well-Founded Semantics
- Author
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Belmar, J., primary, Cuevas, J., additional, and Caniupan, M., additional
- Published
- 2011
- Full Text
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36. A supramolecular approach to the analysis of the crystal structures of some 1-alkyl-3-methyl-4-acyl-5-pyrazolone derivatives
- Author
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Hidalgo, P. I., primary, Belmar, J., additional, Ortiz, L., additional, Jiménez, C. A., additional, Pasán, J., additional, and Ruiz-Pérez, C., additional
- Published
- 2011
- Full Text
- View/download PDF
37. Multifunctional GdIII5-core nanoparticles directed by alkylnitrosopyrazolones
- Author
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Pasán, J., primary, Belmar, J., additional, Quezada, J., additional, Jiménez, C. A., additional, Lahoz, F., additional, Hernández-Creus, A., additional, Julve, M., additional, and Ruiz-Pérez, C., additional
- Published
- 2011
- Full Text
- View/download PDF
38. Amide to amide interactions: from strong to weak hydrogen bonds in bis(quinoxaline-carboxamide) functionality
- Author
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Jiménez, C. A., primary, Parra, N., additional, Hidalgo, P. I., additional, Belmar, J., additional, Pasán, J., additional, and Ruiz-Pérez, C., additional
- Published
- 2011
- Full Text
- View/download PDF
39. Estudio de la mortalidad post-UCI durante 4 años (2006-2009). Análisis de factores en relación con el fallecimiento en planta tras el alta de UCI
- Author
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Abizanda Campos, R., primary, Altaba Tena, S., additional, Belenguer Muncharaz, A., additional, Más Font, S., additional, Ferrándiz Sellés, A., additional, Mateu Campos, L., additional, and de León Belmar, J., additional
- Published
- 2011
- Full Text
- View/download PDF
40. Study of post-ICU mortality during 4 years (2006–2009). Analysis of the factors related to death in the ward after discharge from the ICU
- Author
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Abizanda Campos, R., primary, Altaba Tena, S., additional, Belenguer Muncharaz, A., additional, Más Font, S., additional, Ferrándiz Sellés, A., additional, Mateu Campos, L., additional, and de León Belmar, J., additional
- Published
- 2011
- Full Text
- View/download PDF
41. ChemInform Abstract: Synthesis and Prototropic Tautomerism of 1-n-Alkyl-3-methyl-4-nitroso- 5-pyrazolones.
- Author
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BARTULIN, J., primary, BELMAR, J., additional, GALLARDO, H., additional, and LEON, G., additional
- Published
- 2010
- Full Text
- View/download PDF
42. ChemInform Abstract: Synthesis and Mesomorphic Properties of 5-(p-n-Alkoxy)phenyl-2-(p-n- octyloxy)benzylideneamino-1,3,4-thiadiazoles.
- Author
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PARRA, M., primary, BELMAR, J., additional, ZUNZA, H., additional, ZUNIGA, C., additional, VILLOUTA, SH., additional, and MARTINEZ, R., additional
- Published
- 2010
- Full Text
- View/download PDF
43. ChemInform Abstract: Synthesis and Mesomorphic Properties of Azo Compounds (I) and (II) Derived from Phenyl- and Thienyl-1,3,4-thiadiazole.
- Author
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PARRA, M., primary, VILLOUTA, SH., additional, VERA, V., additional, BELMAR, J., additional, ZUNIGA, C., additional, and ZUNZA, H., additional
- Published
- 2010
- Full Text
- View/download PDF
44. ELECTROCHEMICAL AND COMPUTATIONAL STUDY OF COPPER (II) ALKYLPYRAZOLONE BASED ENAMINE COMPLEX
- Author
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MORENO, Y, primary, BELMAR, J, additional, BROVELLI, F, additional, BULJAN, A, additional, PEÑA, O, additional, and MORENO, L, additional
- Published
- 2008
- Full Text
- View/download PDF
45. Infecciones por Listeria monocytogenes en mujeres embarazadas: experiencia del Hospital Clínico de la Pontificia Universidad Católica de Chile
- Author
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Larraín de la C, Demetrio, primary, Abarzúa C, Fernando, additional, de Jourdan H, Francisca, additional, Merino O, Paulina, additional, Belmar J, Cristián, additional, and García C, Patricia, additional
- Published
- 2008
- Full Text
- View/download PDF
46. Pesquisa de sífilis congénita al momento del parto: ¿Suero materno o sangre de cordón?
- Author
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Abarzúa C, Fernando, primary, Belmar J, Cristián, additional, Rioseco R, Alonso, additional, Parada B, Jacqueline, additional, Quiroga G, Teresa, additional, and García C, Patricia, additional
- Published
- 2008
- Full Text
- View/download PDF
47. Synthesis and mesomorphic properties of 3‐(4‐n‐alkyloxyarylaminomethylene)chroman‐2,4‐diones
- Author
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Alderete, J., primary, Belmar, J., additional, Parra, M., additional, Zárraga, M., additional, and Zúñiga, C., additional
- Published
- 2008
- Full Text
- View/download PDF
48. Organ donation: Professionals attitude in primary health care
- Author
-
Villaescusa Pedemonte, M., primary, Conesa Bernal, C., additional, Alarcon Gonzalez, J. A., additional, Gomez Ruiz, M., additional, Soler Garcia, R., additional, and Valdes Belmar, J. L., additional
- Published
- 2008
- Full Text
- View/download PDF
49. Professional attitudes in primary health care: An organ donation program is needed?
- Author
-
Villaescusa Pedemonte, M., primary, Conesa Bernal, C., additional, Alarcon Gonzalez, J. A., additional, Gomez Ruiz, M., additional, Soler Garcia, R., additional, and Valdes Belmar, J. L., additional
- Published
- 2008
- Full Text
- View/download PDF
50. POLYPEPTIDES FORMED BY ACIDIFICATION OF BLOOD SERUM
- Author
-
Croxatto, H., primary, Pereda, T., additional, Belmar, J., additional, and Labarca, E., additional
- Published
- 2006
- Full Text
- View/download PDF
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