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Se presentan los valores obtenidos para los indicadores ambientales que representan el comportamiento ambiental de la UPV a lo largo del año 2022, también se proporciona información sobre el cumplimiento con los requisitos legales ambientales y los resultados de las auditorías ambientales, así como los puntos fuertes del sistema y las oportunidades de mejora

Se presentan los principales indicadores ambientales calculados por el sistema de gestión ambiental de la UPV y se evalúa el comportamiento ambiental de la misma. Se informa también sobre los objetivos ambientales planteados para el año 2021 y su nivel de cumplimiento final.

Se presentan los principales impactos ambientales que generan los equipos informáticos y se proporcionan indicaciones para reducir ese impacto ambiental, así como para tomar una decisión de compra más responsable. Se incluye información sobre las principales etiquetas y certificaciones relacionados con la sostenibilidad de los equipos informáticos

Objectives This study explored the association of ischemic burden, as measured by vasodilator stress cardiovascular magnetic resonance (CMR), with all-cause mortality and the effect of revascularization on all-cause mortality in patients with stable ischemic heart disease (SIHD). Background In patients with SIHD, the association of ischemic burden, derived from vasodilator stress CMR, with all-cause mortality and its role for decision-making is unclear. Methods The registry consisted of 6,389 consecutive patients (mean age: 65 ± 12 years; 38% women) who underwent vasodilator stress CMR for known or suspected SIHD. The ischemic burden (at stress first-pass perfusion imaging) was computed (17-segment model). The effect of CMR-related revascularization (within the following 3 months) on all-cause mortality was retrospectively explored using the electronic regional health system registry. Results During a 5.75-year median follow-up, 717 (11%) deaths were documented. In multivariable analyses, more extensive ischemic burden (per 1-segment increase) was independently related to all-cause mortality (hazard ratio: 1.04; 95% confidence interval: 1.02 to 1.07; p 5 segments, n = 432; 10% vs. 24%; p = 0.01). Conclusions In a large retrospective registry of unselected patients with known or suspected SIHD who underwent vasodilator stress CMR, extensive ischemic burden was related to a higher risk of long-term, all-cause mortality. Revascularization was associated with a protective effect only in the restricted subset of patients with extensive CMR-related ischemia. Further research will be needed to confirm this hypothesis-generating finding.

[ES] En el Plan Estratégico 2015/2020 de la Universitat Politècnica de València, prorrogado hasta 2021, dentro del Reto Estratégico 5 se establece el Proyecto Estratégico de Sostenibilidad Ambiental. Este compromiso ambiental de la UPV, que se ha materializado con la homologación de su sistema de acuerdo al Reglamento Europeo de Ecogestión y Ecoauditoría (EMAS) y la norma UNE EN ISO 14001, se concreta en diversos objetivos como son: conocer, evaluar y minimizar los impactos ambientales derivados de las actividades universitarias; cumplir con los requisitos legales ambientales; informar, formar y sensibilizar ambientalmente a todos los miembros de la comunidad universitaria; mejorar continuamente el sistema de gestión ambiental de la Universidad y ayudar a mejorar las actuaciones ambientales de las personas que, ajenas a la Universidad, desarrollen su actividad en sus dependencias o para sus centros. En esta declaración ambiental 2020 se describen los componentes del sistema de gestión ambiental, se relacionan los objetivos, metas y plazos de cumplimiento, se detallan los órganos universitarios con responsabilidades ambientales, los indicadores ambientales, los requisitos legales aplicables en materia de medio ambiente y las campañas y actividades de difusión realizadas en la Universidad durante el año 2020.

[EN] OBJECTIVES: This study explored the association of ischemic burden, as measured by vasodilator stress cardiovascular magnetic resonance (CMR), with all-cause mortality and the effect of revascularization on all-cause mortality in patients with stable ischemic heart disease (SIHD). Background: In patients with SIHD, the association of ischemic burden, derived from vasodilator stress CMR, with all-cause mortality and its role for decision-making is unclear. METHODS: The registry consisted of 6,389 consecutive patients (mean age: 65 +/- 12 years; 38% women) who underwent vasodilator stress CMR for known or suspected SIHD. The ischemic burden (at stress first-pass perfusion imaging) was computed (17-segment model). The effect of CMR-related revascularization (within the following 3 months) on all-cause mortality was retrospectively explored using the electronic regional health system registry. RESULTS: During a 5.75-year median follow-up, 717 (11%) deaths were documented. In multivariable analyses, more extensive ischemic burden (per 1-segment increase) was independently related to all-cause mortality (hazard ratio: 1.04; 95% confidence interval: 1.02 to 1.07; p < 0.001). In 1,032 1:1 matched patients using a limited number of variables (516 revascularized, 516 non-revascularized), revascularization within the following 3 months was associated with less all-cause mortality only in patients with extensive CMR-related ischemia (>5 segments, n = 432; 10% vs. 24%; p = 0.01). CONCLUSIONS: In a large retrospective registry of unselected patients with known or suspected SIHD who underwent vasodilator stress CMR, extensive ischemic burden was related to a higher risk of long-term, all-cause mortality. Revascularization was associated with a protective effect only in the restricted subset of patients with extensive CMR-related ischemia. Further research will be needed to confirm this hypothesis-generating finding., Dr. Marcos-Garces and Mr. Gavara contributed equally to the study. This work was supported by the Instituto de Salud Carlos III and co-funded by Fondo Europeo de Desarrollo Regional (FEDER) (grant numbers PI17/01836, PIE15/00013, CIBERCV16/11/00486). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

OBJECTIVES: This study explored the association of ischemic burden, as measured by vasodilator stress cardiovascular magnetic resonance (CMR), with all-cause mortality and the effect of revascularization on all-cause mortality in patients with stable ischemic heart disease (SIHD). Background: In patients with SIHD, the association of ischemic burden, derived from vasodilator stress CMR, with all-cause mortality and its role for decision-making is unclear. METHODS: The registry consisted of 6,389 consecutive patients (mean age: 65 +/- 12 years; 38% women) who underwent vasodilator stress CMR for known or suspected SIHD. The ischemic burden (at stress first-pass perfusion imaging) was computed (17-segment model). The effect of CMR-related revascularization (within the following 3 months) on all-cause mortality was retrospectively explored using the electronic regional health system registry. RESULTS: During a 5.75-year median follow-up, 717 (11%) deaths were documented. In multivariable analyses, more extensive ischemic burden (per 1-segment increase) was independently related to all-cause mortality (hazard ratio: 1.04; 95% confidence interval: 1.02 to 1.07; p < 0.001). In 1,032 1:1 matched patients using a limited number of variables (516 revascularized, 516 non-revascularized), revascularization within the following 3 months was associated with less all-cause mortality only in patients with extensive CMR-related ischemia (>5 segments, n = 432; 10% vs. 24%; p = 0.01). CONCLUSIONS: In a large retrospective registry of unselected patients with known or suspected SIHD who underwent vasodilator stress CMR, extensive ischemic burden was related to a higher risk of long-term, all-cause mortality. Revascularization was associated with a protective effect only in the restricted subset of patients with extensive CMR-related ischemia. Further research will be needed to confirm this hypothesis-generating finding. (C) 2020 by the American College of Cardiology Foundation.

Se presentan los indicadores ambientales más relevantes para evaluar el comportamiento ambiental de la UPV durante el año 2019. Se hace el seguimiento de los objetivos planteados y se describen los cambios acaecidos en la organización y el sistema de gestión ambiental

Background In patients with stable ischemic heart disease (SIHD) the effect of revascularization on all-cause death (the most verifiable clinical event) is unknown. Objectives We explored the potential of the ischemic burden as derived from vasodilator stress cardiovascular magnetic resonance (CMR) to guide decision-making in this scenario. Methods In a large prospective multicenter registry, we recruited 6389 patients (mean age 65±11 years, 38% female) submitted to undergo vasodilator stress CMR for known or suspected SIHD. Baseline and CMR characteristics were prospectively recorded. The ischemic burden (at vasodilator stress first-pass perfusion imaging) and necrosis extent (at late enhancement imaging) were computed (17-segment model). The effect of CMR-related revascularization (within the following three months) on all-cause death (revised using the unified regional electronic health system registry) was explored. Results During a 5.75-year median follow-up, 717 (11.2%) all-cause deaths were documented. In multivariable analyses, more extensive ischemic burden (per 1-segment increase) independently related to all-cause death (1.05 [1.03–1.07], p5 segments (9.3% vs. 16.3%, HR 0.56 [0.32–0.98], p=0.02) but it independently increased risk in 604 patients with ischemic burden ≤5 segments (16.2% vs. 11.3%, HR 1.59 [1.03–2.45], p=0.037). Figure 1. CMR-related revascularization Conclusions In patients with known or suspected stable ischemic heart disease the ischemic burden as derived from vasodilator stress CMR can be helpful to predict the effect of revascularization on long-term all-cause death. Acknowledgement/Funding Funded by “Instituto de Salud Carlos III”/FEDER (PIE15/00013, PI17/01836, and CIBERCV16/11/00486 grants) and Generalitat Valenciana (GV/2018/116).

Se presentan los indicadores ambientales más relevantes para evaluar el comportamiento ambiental de la UPV a lo largo del año 2018

La enfermedad cardiovascular es la primera causa de muerte en todo el mundo. Se calcula que en 2012 murieron por esta causa 17,5 millones de personas, lo cual representa el 31 % de todas las muertes del mundo. De estos fallecimientos el 42 % se atribuyó a la cardiopatía isquémica. Existen dos modalidades principales en la cardiopatía isquémica: una estable en la que el paciente presenta síntomas con un umbral determinado de esfuerzo, y otra aguda, en la que una rotura de la placa de ateroma forma un trombo en la luz arterial provocando mayor o menor obstrucción del flujo, con la consecuente aparición de un Síndrome Coronario Agudo (SCA). Los objetivos del presente estudio observacional retrospectivo son describir los factores de riesgo cardiovascular, definir el uso de los distintos fármacos antiplaquetarios prescritos tras el alta hospitalaria, y analizar el control lipídico general por subgrupos (diabetes, dislipemia, edad y sexo) de una muestra de pacientes que han sufrido un SCA y han sido sometidos a una angioplastia primaria. Cardiovascular disease is the leading cause of death worldwide. It is estimated that in 2012 17.5 million people died because of it, which represents 31 % of all deaths in the world. 42 % of these deaths were attributed to ischemic heart disease. There are two main modalities in ischemic heart disease: a stable one in which the patient presents symptoms with a determined threshold of effort, and another acute one in which a rupture of the atheroma plaque forms a thrombus in the arterial lumen causing greater or lesser obstruction of the flow, with the consequent appearance of an Acute Coronary Syndrome (ACS). The objectives of the present retrospective observational study are to describe the cardiovascular risk factors, to define the use of the different antiplatelet drugs prescribed after hospital discharge and to analyze the general lipid control by subgroups (diabetes, dyslipidemia, age and sex) of a sample of patients who have suffered from ACS and have undergone a primary angioplasty. Medicina

Ventricular fibrillation (VF) signals are characterized by highly volatile and erratic electrical impulses, the analysis of which is difficult given the complex behavior of the heart rhythms in the left (LV) and right ventricles (RV), as sometimes shown in intracardiac recorded Electrograms (EGM). However, there are few studies that analyze VF in humans according to the simultaneous behavior of heart signals in the two ventricles. The objective of this work was to perform a spectral and a non-linear analysis of the recordings of 22 patients with Congestive Heart Failure (CHF) and clinical indication for a cardiac resynchronization device, simultaneously obtained in LV and RV during induced VF in patients with a Biventricular Implantable Cardioverter Defibrillator (BICD) Contak Renewal IV(TM) (Boston Sci.). The Fourier Transform was used to identify the spectral content of the first six seconds of signals recorded in the RV and LV simultaneously. In addition, measurements that were based on Information Theory were scrutinized, including Entropy and Mutual Information. The results showed that in most patients the spectral envelopes of the EGM sources of RV and LV were complex, different, and with several frequency peaks. In addition, the Dominant Frequency (DF) in the LV was higher than in the RV, while the Organization Index (OI) had the opposite trend. The entropy measurements were more regular in the RV than in the LV, thus supporting the spectral findings. We can conclude that basic stochastic processing techniques should be scrutinized with caution and from basic to elaborated techniques, but they can provide us with useful information on the biosignals from both ventricles during VF.

Se presentan los valores de los principales indicadores ambientales para evaluar el comportamiento ambiental de la UPV durante el año 2017 Se presenta y evalúa también el grado de cumplimiento de los objetivos ambientales anuales.

El informe presenta todos los datos descriptivos del comportamiento ambiental de la UPV durante el año 2017, Se revisan los indicadores ambientales, el cumplimiento de los requisitos legales, la evolución de las no conformidades y el grado de consecución de los objetivos de los diferentes planes ambientales. También se proponen acciones de mejora que podrían implementarse a lo largo del año siguiente

Universities are unique organisations that have a full range of existing environmental issues. Implementing an environmental management system (EMS) has been proposed as a way for educational organisations to track and improve the management of these environmental issues. Although only a handful of universities have been verified in the European Union Eco-Management Environmental Audit Scheme (EMAS), a large number of institutions and companies all over Europe that have become registered. The complexity of universities has resulted in EMAS implementation barriers that other sector companies do not necessarily face. This study analyses the specific barriers, benefits, and challenges of the implementation process of the EMAS at Universitat Politecnica de Valencia (UPV). As a result, some specific strategies for implementing EMAS are identified. EMAS appears to be a good MES for university campuses due to its adaptability to the complexity of university organisations and their governance structures.

En la Guía se describen los principales aspectos ambientales derivados del uso y mantenimiento de vehículos a motor, así como los impactos ambientales asociados y se presentan las opciones más respetuosas con el medio ambiente. También se trata el mecanismo de gestión de este tipo de vehículos al final de su vida útil

Introduction: We analysed QT dispersion within the first 6 months postinfarction, its relationship with the main established risk stratifiers and its clinical value. Methods and results: In 55 patients with a first Q-wave myocardial infarction the 12-lead electrocardiogram was scanned and digitised for analysis of QT dispersion (QT maximum–QT minimum) at first day (72 [61–96] ms), first week (69 [47–90] ms), first month (67 [46–88] ms) and sixth month (47 [40–74] ms; P Conclusion: QT dispersion decreases progressively during the first months after myocardial infarction. These changes should be taken into account to define cut-off values of clinical interest in this phase. This variable does not seem related to the classic prognosis predictors. In a nonselected postinfarction population it has a low clinical value.

Introduction: ST-segment elevation on Q-leads after an acute myocardial infarction is related to a greater infarct size. The meaning of a further exercise-induced ST-segment elevation in these patients has not been analyzed. Method: Thirty-six patients with ST-segment elevation on Q-leads were studied after a first acute myocardial infarction. Exercise testing and cardiac catheterization were performed at the first week. Left ventricular volumes (ml/m 2 ); the extent of abnormal wall motion (AWM: chords); contractile reserve (AWM improvement with low dose dobutamine) and coronary patency in the culprit artery were analyzed. Cardiac catheterization was repeated at the sixth month in 20 patients; systolic recovery (AWM improvement), left ventricular volumes and coronary patency were again evaluated. Results: Patients with exercise-induced ST-segment elevation in two or more Q-leads ( n =21) showed lesser contractile reserve (6±6 vs. 12±7 chords, P =0.01) than patients without exercise-induced ST-segment elevation ( n =13). AWM ( F =8.1) and absence of exercise-induced ST-segment elevation ( F =9.5; positive predictive value: 80%; negative predictive value: 68%) were the only independent predictors of contractile reserve. Nevertheless, this electrocardiographic sign was not related to left ventricular volumes, coronary patency or systolic function and it did not predicted late systolic recovery. Conclusions: In patients with baseline ST-segment elevation on Q-leads an exercise-induced ST-segment elevation is independently related to a lesser contractile reserve but not to the evolution of volumes or regional dysfunction during the first 6 months post-infarction. Therefore, the clinical value of this sign seems to be limited to the non-invasive detection of myocardial viability during the early post-infarction phase.

[ES] Para alcanzar la sostenibilidad en países, organizaciones y demás entornos, es necesario contar con indicadores. La Huella Ecológica es un indicador que evalúa dos principios básicos del desarrollo sostenible: el principio de sostenibilidad y el principio de equidad. Dado que la Huella Ecológica se ajusta al concepto de indicador de desempeño ambiental, puede ser integrado en sistemas de gestión ambiental para ser evaluado con facilidad. Hoy en día, pueden encontrarse en literatura reciente distintas metodologías para las diferentes áreas: países, corporaciones y organización, como las universidades, entre otros. Sin embargo, se evidencia una falta de estandarización que permita llevar a cabo comparaciones, seguimientos y análisis de resultados provechosos. En este trabajo, se describen las bases del indicador Huella Ecológica. Se analizan sus ventajas e inconvenientes para delinear un plan de evaluación de este indicador., [EN] To achieve sustainability in countries, organizations and all kind of environments, indicators are needed. The Ecological Footprint is an indicator that evaluates two basic principles of sustainable development: the sustainability principle and the principle of equity. As Ecological Footprint concept complies with the bases of environmental performance indicator it can be integrated in environmental management system to be easily assessed. Nowadays, methodologies for different areas as countries, corporation and organizations as universities between others, can be found in recent literature. However, there is still a lack of standardization that allows comparisons, monitoring and a profitable result analysis. In this paper, bases of Ecological Footprint indicator are described; benefits and shortcomings are analyzed to outline a roadmap of Ecological Footprint assessment.