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16 results on '"Bellocchi, Daniele"'

1. Composition and seasonal variation of volatile organic compounds in Santolina etrusca (Lacaita) Marchi & D'Amato found at Acquapendente (Viterbo, Central Italy).

Author

D'Auria, Maurizio, Bellocchi, Daniele, Battellocchi, Giuseppe, Monachino, Chiara, Guidobaldi, Elena, Marucci, Francesca, and Billi, Luciana

Subjects
VOLATILE organic compounds, ESSENTIAL oils, SEASONS, PLANT collecting
Abstract

The main component of the essential oil of Santolina etrusca is viridiflorol (23.98–42.23%). a compound not found in the essential oil of Santolina camaecyparissus. The main component found in this study is the same found in the essential oil obtained from plants collected in Tuscany and Umbria. However, there are important differences in the other components of the essential oil, where we found the presence of eucalyptol (2.98–9.73%) and germacrene D (2.39–19.59%). Finally, seasonal variation of the essential oil composition induces a reduction of sesquiterpenes amounts with the corresponding increase of the monoterpenes during spring and summer. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Composition and seasonal variation of volatile organic compounds in Santolina etrusca (Lacaita) Marchi & D’Amato found at Acquapendente (Viterbo, Central Italy)

Author

D’Auria, Maurizio, Bellocchi, Daniele, Battellocchi, Giuseppe, Monachino, Chiara, Guidobaldi, Elena, Marucci, Francesca, and Billi, Luciana

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

The main component of the essential oil of Santolina etrusca is viridiflorol (23.98–42.23%). a compound not found in the essential oil of Santolina camaecyparissus. The main component found in this study is the same found in the essential oil obtained from plants collected in Tuscany and Umbria. However, there are important differences in the other components of the essential oil, where we found the presence of eucalyptol (2.98–9.73%) and germacrene D (2.39–19.59%). Finally, seasonal variation of the essential oil composition induces a reduction of sesquiterpenes amounts with the corresponding increase of the monoterpenes during spring and summer.

Published
2022

6. Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors

Author

Liscio, Paride, primary, Carotti, Andrea, additional, Asciutti, Stefania, additional, Karlberg, Tobias, additional, Bellocchi, Daniele, additional, Llacuna, Laura, additional, Macchiarulo, Antonio, additional, Aaronson, Stuart A, additional, Schüler, Herwig, additional, Pellicciari, Roberto, additional, and Camaioni, Emidio, additional

Published
2014
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7. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ

Author

Pellicciari, Roberto, primary, Camaioni, Emidio, additional, Gilbert, Adam M., additional, Macchiarulo, Antonio, additional, Bikker, Jack A., additional, Shah, Falgun, additional, Bard, Joel, additional, Costantino, Gabriele, additional, Gioiello, Antimo, additional, Robertson, Graeme M., additional, Sabbatini, Paola, additional, Venturoni, Francesco, additional, Liscio, Paride, additional, Carotti, Andrea, additional, Bellocchi, Daniele, additional, Cozzi, Andrea, additional, Wood, Andrew, additional, Gonzales, Cathleen, additional, Zaleska, Margaret M., additional, Ellingboe, John W., additional, and Moroni, Flavio, additional

Published
2011
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16. Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin:  From a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses

Author

Macchiarulo, Antonio, Costantino, Gabriele, Meniconi, Mirco, Pleban, Karin, Ecker, Gerhard, Bellocchi, Daniele, and Pellicciari, Roberto

Abstract

The very late antigen-4 (VLA-4), also known as integrin 41, is expressed on monocytes, T- and B-lympohocytes, basophils, and eosinophils and is involved in the massive recruitment of granulocytes in different pathological conditions such as multiple sclerosis and asthma. VLA-4 interacts with its endogenous ligand VCAM-1 during chronic inflammation, and blockade of VLA-4 /VCAM-1 interaction is a potential target for immunosuppression. Two classes of VLA-4 antagonists have so far been reported:  -amino acid derivatives containing a diaryl urea moiety (BIO-1211) and phenylalanine derivatives (TR-14035). With the aim of clarifying the structural basis responsible for VLA-4 recognition by phenylalanine derivatives, we developed a combined computational study on a set of 128 antagonists available through the literature. Our computational approach is composed of three parts. (i) A VCAM-1 based pharmacophore was constructed with a restricted number of phenylalanine derivatives to identify the region of the protein that resembles synthetic antagonists. The pharmacophore was instrumental in constructing an alignment of a set of 128 compounds. This alignment was exploited to build a pseudoreceptor model with the RECEPTOR program. (ii) 3D-QSAR analysis was carried out on the computed electrostatic and steric interaction energies with the pseudoreceptor surface. The 3D-QSAR analysis yielded a predictive model able to explain much of the variance of the 128 antagonists. (iii) A homology modeling study of the headpiece of VLA-4 based on the crystal structure of v3 was performed. Docking experiments of TR-14035 into the binding site of VLA-4 aided the interpretation of the 3D-QSAR model. The obtained results will be fruitful for the design of new potent and selective antagonists of VLA-4.

Published
2004
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