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611 results on '"Belley‐Cote, Emilie"'

1. European Society of Intensive Care Medicine clinical practice guideline on fluid therapy in adult critically ill patients. Part 1: the choice of resuscitation fluids

Author

Arabi, Yaseen M., Belley-Cote, Emilie, Carsetti, Andrea, De Backer, Daniel, Donadello, Katia, Juffermans, Nicole P., Hammond, Naomi, Laake, Jon Henrik, Liu, Dawei, Maitland, Kathryn, Messina, Antonio, Møller, Morten Hylander, Poole, Daniele, Mac Sweeney, Rob, Vincent, Jean-Louis, Zampieri, Fernando G., and AlShamsi, Fayez more...

Published
2024
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3. A sub-study of the POISE-3 randomized trial examined effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury

Author

Garg, Amit X., Marcucci, Maura, Cuerden, Meaghan S., Sontrop, Jessica M., Painter, Thomas W., Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Leslie, Kate, Duceppe, Emmanuelle, Parikh, Chirag R., Roshanov, Pavel, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Meyhoff, Christian S., Short, Timothy G., Amir, Mohammed, Torres, David, Wittmann, Maria, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel L., Jayaram, Raja, Polanczyk, Carisi A., Fleischmann, Edith, Tandon, Vikas, Astrakov, Sergey V., Conen, David, Kei Wu, William Ka, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Ofori, Sandra N., Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce M., Srinathan, Sadeesh, Ismoilov, Samandar, Wang, Michael Ke, Kurz, Andrea, Belley-Cote, Emilie P., Bhatt, Keyur, Eikelboom, John, Gross, Peter, Lamy, Andre, McGillion, Michael, McIntyre, William, Richards, Toby, Spence, Jessica, Van Helder, Thomas, Whitlock, Richard, and Devereaux, P.J. more...

Published
2025
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5. Strategies to reduce out-of-pocket medication costs for Canadians with peripheral arterial disease

Author

McClure, Graham R., Mclntyre, William F., Belesiotis, Peter, Kaplovitch, Eric, Chan, Noel, Bhagirath, Vinai, Chahill, Gurneet, Hayes, Abigail, Sohi, Gursharan, Bordman, Wendy, Whitlock, Richard P., Anand, Sonia S., and Belley-Cote, Emilie P. more...

Subjects
Care and treatment, Economic aspects, Research, Methods, Cost reduction, Health care costs -- Research, Peripheral vascular diseases -- Care and treatment -- Economic aspects, Medical research, Cost control -- Methods, Out-of-pocket expenses -- Research, Prescriptions (Drugs) -- Economic aspects, Medical care, Cost of -- Research, Medicine, Experimental, Drugs -- Prescribing
Abstract

An estimated 1.5 million Canadians older than 40 years live with symptomatic peripheral artery disease (PAD), and globally it affects more than 230 million people, a burden that will rise [...], Background: Given that peripheral arterial disease (PAD) disproportionately affects people of lower socioeconomic status, out-of-pocket expenses for preventive medications are a major barrier to their use. We carried out a cost comparison of drug therapies for PAD to identify prescribing strategies that minimize out-of-pocket expenses for these medications. Methods: Between March and June 2019, we contacted outpatient pharmacies in Hamilton, Ontario, Canada, to assess pricing of pharmacologic therapies at dosages included in the 2016 American College of Cardiology/American Heart Association guideline for management of lower extremity PAD. We also gathered pricing information for supplementary charges, including delivery, pill splitting and blister packaging. We calculated prescription prices with and without dispensing fees for 30-day brand-name and generic prescriptions, and 90-day generic prescriptions. Results: Twenty-four pharmacies, including hospital-based, independent and chain, were included in our sample. In the most extreme scenario, total 90-day medication costs could differ by up to $1377.26. Costs were affected by choice of agent within a drug class, generic versus brand-name drug, quantity dispensed, dispensing fee and delivery cost, if any. Conclusion: By opting for prescriptions for 90 days or as long as possible, selecting the lowest-cost generic drugs available in each drug class, and identifying dispensing locations with lower fees, prescribers can minimize out-of-pocket patient medication expenses. This may help improve adherence to guideline-recommended therapies for the secondary prevention of vascular events in patients with PAD. Contexte : La maladie artérielle périphérique (MAP) affectant de manière disproportionnée les personnes à faible statut socioéconomique, les dépenses personnelles liées aux médicaments préventifs restreignent fortement leur utilisation. Nous avons comparé les coûts des traitements médicamenteux de la MAP pour cerner des stratégies de prescription qui réduisent au minimum les dépenses personnelles associées. Méthodes : Entre mars et juin 2019, nous avons contacté des pharmacies pour patients externes à Hamilton (Ontario, Canada) afin d'évaluer la tarification de traitements pharmacologiques aux doses incluses dans la ligne directrice de prise en charge de la MAP des membres inférieurs publiée en 2016 par l'American College of Cardiology et l'American Heart Association. Nous avons aussi recueilli des informations sur les frais supplémentaires, dont ceux pour la livraison, la coupe des comprimés et l'emballage. Nous avons calculé le prix d'un approvisionnement de 30 jours de médicaments d'ordonnance génériques et de marque et d'un approvisionnement de 90 jours de médicaments d'ordonnance génériques avec et sans frais d'exécution d'ordonnance. Résultats : Notre échantillon comprenait 24 pharmacies, dont des pharmacies d'hôpital, indépendantes et faisant partie d'une chaîne. La différence la plus élevée pour le prix total d'un approvisionnement de 90 jours de médicaments a atteint 1377,26 $. Les paramètres de variation des coûts comprenaient l'agent choisi dans une classe de médicaments, l'emploi d'un médicament générique ou de marque, la quantité délivrée, les frais d'exécution d'ordonnance et les frais de livraison, le cas échéant. Conclusion : Pour réduire au minimum les dépenses personnelles liées aux médicaments, les médecins prescripteurs peuvent privilégier une ordonnance de 90 jours ou d'une durée aussi longue que possible, choisir les médicaments génériques les moins chers dans chaque classe et repérer les établissements de distribution aux frais inférieurs. Cela peut améliorer l'adhésion aux thérapies recommandées par la ligne directrice pour la prévention secondaire d'accidents vasculaires chez les patients atteints de MAP. more...

Published
2024
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9. The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials

Author

Au, Emily, Zhao, Karen, Belley-Côté, Emilie, Song, Yuri, Al-Hazzani, Waleed, Sadeghirad, Behnam, Wang, Eugene, Young, Jack, Kashani, Hessam, Kavosh, Morvarid, Inami, Toru, Beaver, Chris, Kloppenburg, Shelley, Mazer, David, Jacobsohn, Eric, Um, Kevin, and Spence, Jessica more...

Published
2024
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10. Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy

Author

Bainey, Kevin R., Marquis-Gravel, Guillaume, Belley-Côté, Emilie, Turgeon, Ricky D., Ackman, Margaret L., Babadagli, Hazal E., Bewick, David, Boivin-Proulx, Laurie-Anne, Cantor, Warren J., Fremes, Stephen E., Graham, Michelle M., Lordkipanidzé, Marie, Madan, Mina, Mansour, Samer, Mehta, Shamir R., Potter, Brian J., Shavadia, Jay, So, Derek F., Tanguay, Jean-François, Welsh, Robert C., Yan, Andrew T., Bagai, Akshay, Bagur, Rodrigo, Bucci, Claudia, Elbarouni, Basem, Geller, Carol, Lavoie, Andrea, Lawler, Patrick, Liu, Shuangbo, Mancini, John, and Wong, Graham C. more...

Published
2024
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13. Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium (B-Free): A Protocol for a Multi-centre Randomized Cluster Crossover Trial

Author

Spence, Jessica, Belley-Côté, Emilie, Jacobsohn, Eric, Lee, Shun Fu, D’Aragon, Frederick, Avidan, Michael, Mazer, C. David, Rousseau-Saine, Nicolas, Rajamohan, Raja, Pryor, Kane, Klein, Rael, Tan, Edmund (Chong-How), Cameron, Matthew, Di Sante, Emily, DeBorba, Erin, Mustard, Mary, Couture, Etienne, Zamper, Raffael, Law, Michael, Djaiani, George, Saha, Tarit, Choi, Stephen, Hedlin, Peter, Pikaluk, Ryan, Lam, Wing Ying, Deschamps, Alain, Whitlock, Richard, Dulong, Braden, Devereaux, P.J., Beaver, Chris, Kloppenburg, Shelley, Oczkowski, Simon, McIntyre, William Finlay, McFarling, Matthew, Lamy, Andre, Vincent, Jessica, and Connolly, Stuart more...

Published
2023
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14. Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies

Author

Wang, Eugene, Belley-Côté, Emilie P., Young, Jack, He, Henry, Saud, Haris, D'Aragon, Frederick, Um, Kevin, Alhazzani, Waleed, Piticaru, Joshua, Hedden, Matthew, Whitlock, Richard, Mazer, C. David, Kashani, Hessam H., Zhang, Sarah Yang, Lucas, Amanda, Timmerman, Nicholas, Nishi, Cameron, Jain, Davinder, Kugler, Aaron, Beaver, Chris, Kloppenburg, Shelley, Schulman, Sam, Borges, Flavia K., Kavosh, Morvarid, Wada, Chihiro, Lin, Sabrina, Sibilio, Serena, Lauw, Mandy, Benz, Alexander, Szczeklik, Wojciech, Mokhtari, Arastoo, Jacobsohn, Eric, and Spence, Jessica more...

Published
2023
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15. Inotrope versus placebo therapy in cardiogenic shock: Rationale and study design of the CAPITAL DOREMI2 trial

Author

Parlow, Simon, Santo, Pietro Di, Sterling, Lee H., Goodliffe, Laura, Motazedian, Pouya, Prosperi-Porta, Graeme, Morgan, Baylie, Koopman, Zandra, Jung, Richard G., Lepage-Ratte, Melissa Fay, Robinson, Lisa, Feagan, Hannah, Simard, Trevor, Wells, George A., Kyeremanteng, Kwadwo, Ainsworth, Craig, Amin, Faizan, Marbach, Jeffrey A., Fernando, Shannon M., Labinaz, Marino, Belley-Cote, Emilie P., Hibbert, Benjamin, and Mathew, Rebecca more...

Published
2023
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16. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis

Author

Vaara, Suvi T., Serpa Neto, Ary, Bellomo, Rinaldo, Adhikari, Neill K. J., Dreyfuss, Didier, Gallagher, Martin, Gaudry, Stephane, Hoste, Eric, Joannidis, Michael, Pettilä, Ville, Wang, Amanda Y., Kashani, Kianoush, Wald, Ron, Bagshaw, Sean M., Ostermann, Marlies, Bagshaw, Sean M, Wald, Ron, Adhikari, Neill K.J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Bellomo, Rinaldo, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Gallagher, Martin P., Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Joannidis, Michael, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric A., Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Maisonneuve-Rosemont, Lafrance, Jean-Philippe, Lamontagne, François, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Langis Francoeur, Charles, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Tung Sia, Ying, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Rochwerg, Bram, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, Bagshaw, Sean M., van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Stelfox, Henry T., Ruddell, Stacey, Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Wald, Ron, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, Jennifer, Dodek, Peter, Ayas, Najib, Alcuaz, Victoria, Suen, Gabriel, Rewa, Oleksa, Singh, Gurmeet, Norris, Sean, Gibson, Neil, Arias, Castro, Shami, Aysha, Pelletier, Celine, Adhikari, Neill K.J., Zahirieh, Alireza, Amaral, Andre, Marinoff, Nicole, Kaur, Navjot, Perez, Adic, Wang, Jane, Haljan, Gregory, Condin, Christopher, McIntyre, Lauralyn, Gomes, Brigette, Porteous, Rebecca, Watpool, Irene, Hiremath, Swapnil, Clark, Edward, Herridge, Margaret S., Backhouse, Felicity, Elizabeth Wilcox, M., Walczak, Karolina, Ki, Vincent, Sharman, Asheer, Romano, Martin, Bagshaw, Sean M., Noel Gibney, R.T., Romanovsky, Adam S., Rewa, Oleksa, McCoshen, Lorena, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Duan, Meili, Ji, Xiaojun, Guo, Dongchen, Qi, Zhili, Lin, Jin, Zhang, Meng, Dong, Lei, Liu, Jingfeng, Liu, Pei, Zhi, Deyuan, Bai, Guoqiang, Qiu, Yu, Yang, Ziqi, Bai, Jing, Liu, Zhuang, Zhuang, Haizhou, Wang, Haiman, Li, Jian, Zhao, Mengya, Zhou, Xiao, Shi, Xianqing, Ye, Baning, Liu, Manli, Wu, Jing, Fu, Yongjian, Long, Dali, Pan, Yu, Wang, Jinlong, Mei, Huaxian, Zhang, Songsong, Wen, Mingxiang, Yang, Enyu, Mu, Sijie, Li, Jianquan, Hu, Tingting, Qin, Bingyu, Li, Min, Wang, Cunzhen, Dong, Xin, Wang, Kaiwu, Wang, Haibo, Yang, Jianxu, Du, Bin, Wang, Chuanyao, Wang, Dongxin, Li, Nan, Yu, Zhui, Xu, Song, Yao, Lan, Hou, Guo, Liu, Zhou, Lu, Liping, Lian, Yingtao, Wang, Chunting, Zhang, Jichen, Ding, Ruiqi, Qi, Guoqing, Wang, Qizhi, Wang, Peng, Meng, Zhaoli, Chen, Man, Hu, Xiaobo, He, Xiandi, Zhao, Shibing, Hang, Lele, Li, Rui, Qin, Suhui, Lu, Kun, Dun, Shijuan, Liu, Cheng, Zhou, Qi, Chen, Zhenzhen, Mei, Jing, Zhang, Minwei, Xu, Hao, Lin, Jincan, Shi, Qindong, Fu, Lijuan, Zeng, Qinjing, Ma, Hongye, Yan, Jinqi, Gao, Lan, Liu, Hongjuan, Zhang, Lei, Li, Hao, He, Xiaona, Fan, Jingqun, Guo, Litao, Liu, Yu, Wang, Xue, Sun, Jingjing, Liu, Zhongmin, Yang, Juan, Ding, Lili, Sheng, Lulu, Liu, Xingang, Yan, Jie, Wang, Quihui, Wang, Yifeng, Zhao, Dan, Zhao, Shuangping, Hu, Chenghuan, Li, Jing, Deng, Fuxing, Qiu, Haibo, Yang, Yi, Mo, Min, Pan, Chun, Wu, Changde, Huang, Yingzi, Huang, Lili, Liu, Airan, Pettilä, Ville, Vaara, Suvi T., Korhonen, Anna-Maija, Törnblom, Sanna, Sutinen, Sari, Pettilä, Leena, Heinonen, Jonna, Lappi, Eliria, Suhonen, Taria, Karlsson, Sari, Hoppu, Sanna, Jalkanen, Ville, Kuitunen, Anne, Levoranta, Markus, Långsjö, Jaakko, Ristimäki, Sanna, Malila, Kaisa, Wootten, Anna, Varila, Simo, Järvisalo, Mikko J, Inkinen, Outi, Kentala, Satu, Leivo, Keijo, Haltia, Paivi, Dreyfuss, Didier, Ricard, Jean-Damien, Messika, Jonathan, Tiagarajah, Abirami, Emery, Malo, Dechanet, Aline, Gernez, Coralie, Roux, Damien, Martin-Lefevre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Claude Lacherade, Jean, Colin, Gwenhaël, Lebert, Christine, Azais, Marie-Ange, Yehia, Aihem, Pouplet, Caroline, Henry- Lagarrigue, Matthieu, Seguin, Amélie, Crosby, Laura, Maizel, Julien, Titeca-Beauport, Dimitri, Combes, Alain, Nieszkowska, Ania, Masi, Paul, Demoule, Alexandre, Mayaux, Julien, Dres, Martin, Morawiec, Elise, Decalvele, Maxens, Demiri, Suela, Faure, Morgane, Marios, Clémence, Mallet, Maxime, Amélie Ordon, Marie, Morizot, Laura, Cantien, Marie, Pousset, François, Gaudry, Stéphane, Poirson, Florent, Cohen, Yves, Argaud, Laurent, Cour, Martin, Bitker, Laurent, Simon, Marie, Hernu, Romain, Baudry, Thomas, De La Salle, Sylvie, Robine, Adrien, Sedillot, Nicholas, Tchenio, Xavier, Bouisse, Camille, Roux, Sylvie, Barbar, Davide, Trusson, Rémi, Tamion, Fabienne, Grangé, Steven, Carpentier, Dorothée, Chevrel, Guillaume, Ensenyat-Martin, Luis, Marque, Sophie, Quenot, Jean-Pierre, Andreu, Pascal, Dargent, Auguste, Large, Audrey, Chudeau, Nicolas, Landais, Mickael, Derrien, Benoit, Christophe Callahan, Jean, Guitton, Christophe, Le Moal, Charlène, Robert, Alain, Asehnoune, Karim, Cinotti, Raphaël, Grillot, Nicolas, Demeure, Dominique, Vinsonneau, Christophe, Rahmani, Imen, Marzouk, Mehdi, Dekeyser, Thibault, Sejourne, Caroline, Verlay, Mélanie, Thevenin, Fabienne, Delecolle, Lucie, Didier Thevenin, Lens, Souweine, Bertrand, Coupez, Elisabeth, Adda, Mireille, Eraldi, Jean-Pierre, Marchalot, Antoine, De Prost, Nicolas, Mekontso Dessap, Armand, Razazi, Keyvan, Meziani, Ferhat, Boisrame-Helms, Julie, Clere-Jehl, Raphael, Delabranche, Xavier, Kummerlen, Christine, Merdji, Hamid, Monnier, Alexandra, Rabouel, Yannick, Rahmani, Hassene, Allam, Hayat, Chenaf, Samir, Franja, Vincenta, Pons, Bertrand, Carles, Michel, Martino, Frédéric, Richard, Régine, Zuber, Benjamin, Lacave, Guillaume, Lakhal, Karim, Rozec, Bertrand, Dang Van, Hoa, Boulet, Éric, Dubos, René, Fadel, Fouad, Cleophax, Cedric, Dufour, Nicolas, Grant, Caroline, Thuong, Marie, Reignier, Jean, Canet, Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Nichol, Alistair D., Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, McGuinness, Shay, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Schneider, Antoine G., Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Abed Mallaird, Samia, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, George, Aparna, Hussain, Nauman, Pogreban, Tatiana, Lobaz, Steve, Daniels, Alison, Cunningham, Mishell, Kerr, Deborah, Nicholson, Alice, Shanmugasundaram, Pradeep, Abrams, Judith, Manso, Katarina, Hambrook, Geraldine, McKerrow, Elizabeth, Salva, Juvy, Foulkes, Stephen, Wise, Matthew, Morgan, Matt, Brooks, Jenny, Cole, Jade, Michelle Davies, Tracy, Hill, Helen, Thomas, Emma, Vizcaychipi, Marcela, Baharlo, Behrad, Carungcong, Jaime, Costa, Patricia, Martins, Laura, Kapoor, Ritoo, Hazelton, Tracy, Moon, Angela, Musselwhite, Janine, Shelley, Ben, McCall, Philip, Ostermann, Marlies, Arbane, Gill, Bociek, Aneta, Marotti, Martina, Lim, Rosario, Campos, Sara, Grau Novellas, Neus, Cennamo, Armando, Slack, Andrew, Wyncoll, Duncan, Camporota, Luigi, Sparkes, Simon, Tilley, Rosalinde, Rattray, Austin, Moreland, Gayle, Duffy, Jane, McGonigal, Elizabeth, Hopkins, Philip, Finney, Clare, Smith, John, Noble, Harriet, Watson, Hayley, Harris, Claire-Louise, Clarey, Emma, Corcoran, Eleanor, Beck, James, Howcroft, Clare, Youngs, Nora, Wilby, Elizabeth, Ogg, Bethan, Wolverson, Adam, Lee, Sandra, Butler, Susie, Okubanjo, Maryanne, Hindle, Julia, Welters, Ingeborg, Williams, Karen, Johnson, Emily, Patrick-Heselton, Julie, Shaw, David, Waugh, Victoria, Stewart, Richard, Mwaura, Esther, Wren, Lynn, Mew, Louise, Sutherland, Sara-Beth, Adderley, Jane, Ruddy, Jim, Harkins, Margaret, Kaye, Callum, Scott, Teresa, Mitchell, Wendy, Anderson, Felicity, Willox, Fiona, Jagannathan, Vijay, Clark, Michele, Purv, Sarah, Sharman, Andrew, Meredith, Megan, Ryan, Lucy, Conner, Louise, Peters, Cecilia, Harvey, Dan, Roshdy, Ashraf, Collins, Amy, Sim, Malcolm, Henderson, Steven, Chee, Nigel, Pitts, Sally, Bowman, Katie, Dilawershah, Maria, Vamplew, Luke, Howe, Elizabeth, Rogers, Paula, Hernandez, Clara, Prendergast, Clara, Benton, Jane, Rosenberg, Alex, Forni, Lui G., Grant, Alice, Carvelli, Paula, Raithatha, Ajay, Bird, Sarah, Richardson, Max, Needham, Matthew, Hirst, Claire, Ball, Jonathan, Leaver, Susannah, Howlett, Luisa, Castro Delgado, Carlos, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Joseph, Gipsy, Robinson, Francesca, Tridente, Ascanio, Harrop, Clare, Shuker, Karen, McLaughlan, Derek, Ramsey, Judith, Meehan, Sharon, Oliver Rose, Bernd, Reece-Anthony, Rosie, Gurung, Babita, Whitehouse, Tony, Snelson, Catherine, Veenith, Tonny, Johnston, Andy, Cooper, Lauren, Carrera, Ron, Ellis, Karen, Fellows, Emma, Harkett, Samanth, Bergin, Colin, Spruce, Elaine, Despy, Liesl, Goundry, Stephanie, Dooley, Natalie, Mason, Tracy, Clark, Amy, Dignam, Gemma, Ward, Geraldine, Attwood, Ben, Parsons, Penny, Mason, Sophie, Margarson, Michael, Lord, Jenny, McGlone, Philip, Hodgson, Luke E., Chadbourn, Indra, Gomez, Raquel, Margalef, Jordi, Pretorius, Rinus, Hamshere, Alexandra, Carter, Joseph, Cahill, Hazel, Grainger, Lia, Howard, Kate, Forshaw, Greg, Guy, Zoe, Kashani, Kianoush B., Albright, Robert C., Amsbaugh, Amy, Stoltenberg, Anita, Niven, Alexander S., Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Tolwani, Ashita, Lyas, Claretha, Latta, Laura, Bihorac, Azra, Hashemighouchani, Haleh, Efron, Philip, Ruppert, Matthew, Cupka, Julie, Kiley, Sean, Carson, Joshua, White, Peggy, Omalay, George, Brown, Sherry, Velez, Laura, Marceron, Alina, Neyra, Javier A., Carlos Aycinena, Juan, Elias, Madona, Ortiz-Soriano, Victor M., Hauschild, Caroline, and Dorfman, Robert more...

Published
2024
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17. Neuroprognostication in the Post Cardiac Arrest Patient: A Canadian Cardiovascular Society Position Statement

Author

Fordyce, Christopher B., Kramer, Andreas H., Ainsworth, Craig, Christenson, Jim, Hunter, Gary, Kromm, Julie, Lopez Soto, Carmen, Scales, Damon C., Sekhon, Mypinder, van Diepen, Sean, Dragoi, Laura, Josephson, Colin, Kutsogiannis, Jim, Le May, Michel R., Overgaard, Christopher B., Savard, Martin, Schnell, Gregory, Wong, Graham C., Belley-Côté, Emilie, Fantaneanu, Tadeu A., Granger, Christopher B., Luk, Adriana, Mathew, Rebecca, McCredie, Victoria, Murphy, Laurel, and Teitelbaum, Jeanne more...

Published
2023
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18. Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline

Author

Møller, Morten H., Alhazzani, Waleed, Lewis, Kimberley, Belley-Cote, Emilie, Granholm, Anders, Centofanti, John, and McIntyre, William B.

Subjects
McMaster University, Usage, Patient advocacy -- Usage, Hospital patients -- Usage, Dexmedetomidine -- Usage, Medical schools -- Usage, Adults -- Usage, Medical colleges -- Usage
Abstract

Author(s): Morten H. Møller [sup.1], Waleed Alhazzani [sup.2] [sup.3], Kimberley Lewis [sup.2], Emilie Belley-Cote [sup.4], Anders Granholm [sup.1], John Centofanti [sup.5], William B. McIntyre [sup.6] [sup.7], Jessica Spence [sup.3] [sup.8], [...], Purpose The aim of this Intensive Care Medicine Rapid Practice Guideline (ICMâRPG) was to formulate evidenceâbased guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU). Methods We adhered to the methodology for trustworthy clinical practice guidelines, including use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and the Evidence-to-Decision framework to generate recommendations. The guideline panel comprised 28 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. Through teleconferences and webâbased discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients' values and preferences, costs and resources, feasibility, acceptability, and research priorities. Results The ICMâRPG panel issued one weak recommendation (suggestion) based on overall moderate certainty of evidence: 'In invasively mechanically ventilated adult ICU patients, we suggest using dexmedetomidine over other sedative agents, if the desirable effects including a reduction in delirium are valued over the undesirable effects including an increase in hypotension and bradycardia'. Conclusion This ICM-RPG provides updated evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities. more...

Published
2022
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19. Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial

Author

Eikelboom, John W, Jolly, Sanjit S, Belley-Cote, Emilie P, Whitlock, Richard P, Rangarajan, Sumathy, Xu, Lizhen, Heenan, Laura, Bangdiwala, Shrikant I, Tarhuni, Wadea M, Hassany, Mohamed, Kontsevaya, Anna, Harper, William, Sharma, Sanjib Kumar, Lopez-Jaramillo, Patricio, Dans, Antonio L, Palileo-Villanueva, Lia M, Avezum, Alvaro, Pais, Prem, Xavier, Denis, Felix, Camilo, Yusufali, Afzalhussein, Lopes, Renato D, Berwanger, Otavio, Ali, Zeeshan, Wasserman, Sean, Anand, Sonia S, Bosch, Jackie, Choudhri, Shurjeel, Farkouh, Michael E, Loeb, Mark, and Yusuf, Salim more...

Published
2022
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20. Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial

Author

Eikelboom, John W, Jolly, Sanjit S, Belley-Cote, Emilie P, Whitlock, Richard P, Rangarajan, Sumathy, Xu, Lizhen, Heenan, Laura, Bangdiwala, Shrikant I, Luz Diaz, Maria, Diaz, Rafael, Yusufali, Afzalhussein, Kumar Sharma, Sanjib, Tarhuni, Wadea M, Hassany, Mohamed, Avezum, Alvaro, Harper, William, Wasserman, Sean, Almas, Aysha, Drapkina, Oxana, Felix, Camilo, Lopes, Renato D, Berwanger, Otavio, Lopez-Jaramillo, Patricio, Anand, Sonia S, Bosch, Jackie, Choudhri, Shurjeel, Farkouh, Michael E, Loeb, Mark, and Yusuf, Salim more...

Published
2022
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23. The Anti-Coronavirus Therapies (ACT) Trials: Design, Baseline Characteristics, and Challenges

Author

Eikelboom, John, Rangarajan, Sumathy, Jolly, Sanjit S., Belley-Cote, Emilie P., Whitlock, Richard, Beresh, Heather, Lewis, Gayle, Xu, Lizhen, Chan, Noel, Bangdiwala, Shrikant, Diaz, Rafael, Orlandini, Andres, Hassany, Mohamed, Tarhuni, Wadea M., Yusufali, A.M., Sharma, Sanjib Kumar, Kontsevaya, Anna, Lopez-Jaramillo, Patricio, Avezum, Alvaro, Dans, Antonio L., Wasserman, Sean, Felix, Camilo, Kazmi, Khawar, Pais, Prem, Xavier, Denis, Lopes, Renato D., Berwanger, Otavio, Nkeshimana, Menelas, Harper, William, Loeb, Mark, Choudhri, Shurjeel, Farkouh, Michael E., Bosch, Jackie, Anand, Sonia S., and Yusuf, Salim more...

Published
2022
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26. Short-term and Long-term Risk of Stroke in Patients With Perioperative Atrial Fibrillation After Cardiac Surgery: Systematic Review and Meta-analysis

Author

Wang, Michael K., Meyre, Pascal B., Heo, Rachel, Devereaux, P.J., Birchenough, Lauren, Whitlock, Richard, McIntyre, William F., Peter Chen, Yu Chiao, Ali, Muhammad Zain, Biancari, Fausto, Butt, Jawad Haider, Healey, Jeff S., Belley-Côté, Emilie P., Lamy, Andre, and Conen, David more...

Published
2022
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27. Research Consent Models Used in Prospective Studies of Neurologically Deceased Organ Donors : A Systematic Review

Author

Canadian Critical Care Trials Group and the Canadian National Transplant Research Program, D'Aragon, Frederick, Burns, Karen E. A., Yaworski, Amanda, Lucas, Amanda, Arseneau, Erika, Belley-Cote, Emilie, Dhanani, Sonny, Frenette, Anne-Julie, Lamontagne, François, Lauzier, François, Akhtar, Aemal, Oczkowski, Simon, Rochwerg, Bram, and Meade, Maureen O. more...

Published
2020

30. Expertise-based design in surgical trials: a narrative review

Author

Alsagheir, Ali, Koziarz, Alex, Belley-Cote, Emilie P., and Whitlock, Richard P.

Subjects
Analysis, Methods, Clinical trials -- Methods, Research design -- Analysis, Surgical research -- Methods, Experimental design -- Analysis, Surgery, Experimental -- Methods
Abstract

Randomized controlled trials (RCTs) are the most robust study design for assessing an intervention's efficacy and safety. However, when assessing skill-dependent interventions such as surgical interventions, their internal validity can [...], Randomized controlled trials (RCTs) are the most robust study design for evaluating the safety and efficacy of a therapeutic intervention. However, their internal validity are at risk when evaluating surgical interventions. This review summarizes existing expertise-based trials in surgery and related methodological concepts to guide surgeons performing this work. We provide caseloads required to reach the learning curve for various surgical interventions and report criteria for expertise from published and unpublished expertise-based trials. In addition, we review design and implementation concepts of expertisebased trials, including recruitment of surgeons, crossover, ethics, generalizability, sample size and definitions for learning curve. Several RCTs have used an expertise-based design. We found that the majority of definitions used for expertise were vague, heterogeneous, and inconsistent across trials evaluating the same surgical intervention. Statistical methods exist to adjust for the learning curve; however, there is limited guidance. We developed the following criteria for surgical expertise for future trials: 1) decide on the proxy to be used for the learning curve, and 2) assess eligible surgeons by comparing their performance to the previously defined expertise criteria. L'essai randomisé et contrôlé (ERC) représente le modèle d'étude le plus solide pour évaluer l'innocuité et l'efficacité d'une intervention, mais sa validité interne est compromise lorsqu'on évalue des interventions chirurgicales. Cette revue résume les essais existants sur l'expertise en chirurgie et les concepts méthodologiques connexes pour guider les chirurgiens dans leur travail. Nous donnons les volumes de cas requis pour atteindre la courbe d'apprentissage propre à diverses interventions chirurgicales et nous citons les critères d'expertise mentionnés dans les rapports d'essais sur l'expertise publiés et non publiés. Nous passons également en revue les protocoles et les concepts de mises en oeuvre des essais sur l'expertise, y compris le recrutement des chirurgiens, la permutation des groupes, l'éthique, la généralisabilité, la taille des échantillons et les définitions des courbes d'apprentissage. Plusieurs ERC ont utilisé un modèle basé sur l'expertise. Nous avons découvert que la majorité des définitions du terme expertise utilisées étaient vagues, hétérogènes et nconstantes d'un essai à l'autre pour une même intervention chirurgicale. Il existe des méthodes statistiques pour ajuster la courbe d'apprentissage; par contre, on déplore un manque de directives. Nous avons établi les critères suivants pour juger de l'expertise chirurgicale en vue de futurs essais : 1) choisir la mesure indirecte à utiliser pour la courbe d'apprentissage, et 2) évaluer les chirurgiens admissibles en comparant leur rendement aux critères d'expertise définis précédemment. more...

Published
2021
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31. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

Author

Evans, Laura, Rhodes, Andrew, Alhazzani, Waleed, Antonelli, Massimo, Coopersmith, Craig M., French, Craig, Machado, Flávia R., Mcintyre, Lauralyn, Ostermann, Marlies, Prescott, Hallie C., Schorr, Christa, Simpson, Steven, Wiersinga, W. Joost, Alshamsi, Fayez, Angus, Derek C., Arabi, Yaseen, Azevedo, Luciano, Beale, Richard, Beilman, Gregory, Belley-Cote, Emilie, Burry, Lisa, Cecconi, Maurizio, Centofanti, John, Coz Yataco, Angel, De Waele, Jan, Dellinger, R. Phillip, Doi, Kent, Du, Bin, Estenssoro, Elisa, Ferrer, Ricard, Gomersall, Charles, Hodgson, Carol, Møller, Morten Hylander, Iwashyna, Theodore, Jacob, Shevin, Kleinpell, Ruth, Klompas, Michael, Koh, Younsuck, Kumar, Anand, Kwizera, Arthur, Lobo, Suzana, Masur, Henry, McGloughlin, Steven, Mehta, Sangeeta, Mehta, Yatin, Mer, Mervyn, Nunnally, Mark, Oczkowski, Simon, Osborn, Tiffany, Papathanassoglou, Elizabeth, Perner, Anders, Puskarich, Michael, Roberts, Jason, Schweickert, William, Seckel, Maureen, Sevransky, Jonathan, Sprung, Charles L., Welte, Tobias, Zimmerman, Janice, and Levy, Mitchell more...

Published
2021
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32. A systematic review and meta-analysis of the effect of routine early angiography in patients with return of spontaneous circulation after Out-of-Hospital Cardiac Arrest

Author

Belley-Cote, Emilie, Drennan, Ian, Welsford, Michelle, Soar, J., Berg, K.M., Andersen, L.W., Böttiger, B.W., Callaway, C.W., Deakin, C.D., Donnino, M.W., Hsu, C.H., Morley, P.T., Neumar, R.W., Nicholson, T.C., Nolan, J.P., O’Neil, B.J., Paiva, E.F., Parr, M.J., Reynolds, J.C., Sandroni, C., Wang, T.L., Nikolaou, Nikolaos I., Netherton, Stuart, Drennan, Ian R., Nation, Kevin, Torabi, Nazi, and Morrison, Laurie J. more...

Published
2021
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33. Association Between Perioperative Atrial Fibrillation and Long-term Risks of Stroke and Death in Noncardiac Surgery: Systematic Review and Meta-analysis

Author

Huynh, Jessica T., Healey, Jeff S., Um, Kevin J., Vadakken, Maria E., Rai, Anand S., Conen, David, Meyre, Pascal, Butt, Jawad H., Kamel, Hooman, Reza, Seleman J., Nguyen, Stephanie T., Oqab, Zardasht, Devereaux, P.J., Balasubramanian, Kumar, Benz, Alexander P., Belley-Cote, Emilie P., and McIntyre, William F. more...

Published
2021
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35. Heart failure after left atrial appendage occlusion: Insights from the LAAOS III randomized trial.

Author

Krisai, Philipp, Belley‐Cote, Emilie P., McIntyre, William F., Wong, Jorge, Tsiplova, Kate, Brady, Katheryn, Joseph, Philip, Johansson, Isabelle, Johnson, Linda, Xing, Lucas Yixi, Colli, Andrea, McGuinness, Shay, Punjabi, Prakash, Reents, Wilko, Rega, Filip, Budera, Petr, Royse, Alistair G., Paparella, Domenico, Connolly, Stuart, and Whitlock, Richard P. more...

Subjects
*LEFT heart atrium, *HEART failure, *ATRIAL fibrillation, *NATRIURETIC peptides, *BODY mass index, *VENTRICULAR ejection fraction
Abstract

Aims Methods and results Conclusions The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III).Patients (n = 4811) with atrial fibrillation (AF) and a CHA2DS2‐VASc score ≥2, who were having cardiac surgery for another indication, were randomized to undergo surgical LAAO or not. We compared the composite outcome of HF‐related hospitalizations and HF death between the two groups. HF assessment required clinical and radiographic evidence of HF. Analyses included a landmark analysis before and after 30 days and subgroups. Mean age was 71.2 years, 67.5% were male and 57.0% had prior HF. Over a mean follow‐up of 3.8 years, 396 (8.3%) patients met the composite HF outcome: 209 (8.8%) with LAAO (n = 2379) and 187 (7.8%) without LAAO (n = 2391) (hazard ratio [HR] 1.12, 95% confidence interval [CI] 0.92–1.37, p = 0.25). There was no difference between the two groups in the first 30 days (1.6% vs. 1.1%; p = 0.12) and thereafter (7.6% vs. 7.1%; p = 0.57). Subgroups based on age, sex, body mass index, AF type, prior HF, cardiac rhythm or left ventricular ejection fraction showed consistent results. There was no difference in HF outcomes with LAAO between the cut‐and‐sew (HR 0.93, 95% CI 0.70–1.23, p = 0.62) versus other closure methods (HR 1.05, 95% CI 0.77–1.41, p = 0.77).Left atrial appendage occlusion or removal at the time of cardiac surgery does not appear to alter the risk of HF‐related hospitalization or death.Clinical Trial Registration: ClinicalTrials.gov NCT01561651. [ABSTRACT FROM AUTHOR] more...

Published
2024
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36. Small‐volume blood sample collection tubes in adult intensive care units: A rapid practice guideline.

Author

Callum, Jeannie, Putowski, Zbignew, Alhazzani, Waleed, Belley‐Cote, Emilie, Møller, Morten Hylander, Curry, Nicola, Al Duhailib, Zainab, Fung, Mark, Giocobbo, Louise, Granholm, Anders, Louw, Vernon, Maybohm, Patrick, Muller, Marcella, Nielsen, Nathan, Oleschuk, Curtis, Raza, Sheharyar, Scruth, Elizabeth, Siegal, Deborah, Stanworth, Simon J., and Vlaar, Alexander P. J. more...

Subjects
INTENSIVE care patients, INTENSIVE care units, ERYTHROCYTES, BLOOD collection, BLOOD volume
Abstract

Background: This Intensive Care Medicine Rapid Practice Guideline (ICM‐RPG) provides an evidence‐based recommendation to address the question: in adult patients in intensive care units (ICUs), should we use small‐volume or conventional blood collection tubes? Methods: We included 23 panelists in 8 countries and assessed and managed financial and intellectual conflicts of interest. Methodological support was provided by the Guidelines in Intensive Care, Development, and Evaluation (GUIDE) group. We conducted a systematic review, including evidence from observational and randomized studies. Using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, we evaluated the certainty of evidence and developed recommendations using the Evidence‐to‐Decision framework. Results: We identified 8 studies (1 cluster and 2 patient‐level randomized trials; 5 observational studies) comparing small‐volume to conventional tubes. We had high certainty evidence that small‐volume tubes reduce daily and cumulative blood sampling volume; and moderate certainty evidence that they reduce the risk of transfusion and mean number of red blood cell units transfused, but these estimates were limited by imprecision. We had high certainty that small‐volume tubes have a similar rate of specimens with insufficient quantity. The panel considered that the desirable effects of small‐volume tubes outweigh the undesirable effects, are less wasteful of resources, and are feasible, as demonstrated by successful implementation across multiple countries, although there are upfront implementation costs to validate small‐volume tubes on laboratory instrumentation. Conclusion: This ICM‐RPG panel made a strong recommendation for the use of small‐volume sample collection tubes in adult ICUs based on overall moderate certainty evidence. [ABSTRACT FROM AUTHOR] more...

Published
2024
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39. Restricted versus liberal intraoperative benzodiazepine use in cardiac anaesthesia for reducing delirium (B-Free Pilot): a pilot, multicentre, randomised, cluster crossover trial

Author

Spence, Jessica, Belley-Côté, Emilie, Jacobsohn, Eric, Lee, Shun Fu, Whitlock, Richard, Bangdiwala, Shrikant, Syed, Summer, Sarkaria, Anisha, MacIsaac, Sarah, Lengyel, Alexandra, Long, Steven, Um, Kevin, McIntyre, William F., Kavosh, Morvarid, Fast, Ian, Arora, Rakesh, Lamy, Andre, Connolly, Stuart, and Devereaux, P.J. more...

Published
2020
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40. Recurrence of new-onset post-operative AF after cardiac surgery: detected by implantable loop recorders: A systematic review and Meta-analysis

Author

Kaur, Hargun, primary, Tao, Brendan, additional, Silverman, Max, additional, Healey, Jeffrey S., additional, Belley-Cote, Emilie P., additional, Islam, Shofiqul, additional, Whitlock, Richard P., additional, Devereaux, Philip J., additional, Conen, David, additional, Bidar, Elham, additional, Kawczynski, Michal, additional, Ayala-Paredes, Félix, additional, Ayala-Valani, Luciano M, additional, Sandgren, Emma, additional, El-Chami, Mikhael F, additional, Jørgensen, Troels Højsgaard, additional, Thyregod, Hans Gustav Hørsted, additional, Sabbag, Avi, additional, and McIntyre, William F., additional more...

Published
2024
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41. Assay precision and risk of misclassification at rule-out cut-offs for high-sensitivity cardiac troponin

Author

Kavsak, Peter A., primary, Mills, Nicholas L., additional, Clark, Lorna, additional, Ko, Dennis T., additional, Sharif, Sameer, additional, Chen-Tournoux, Annabel, additional, Friedman, Steven M., additional, Belley-Cote, Emilie P., additional, Worster, Andrew, additional, Cox, Jafna, additional, Thiruganasambandamoorthy, Venkatesh, additional, Lou, Amy, additional, Taher, Jennifer, additional, Scheuermeyer, Frank, additional, McCudden, Chris, additional, Abramson, Beth L., additional, Eintracht, Shaun, additional, Shea, Jennifer L., additional, Yip, Paul M., additional, Huang, Yun, additional, Chen, Michael, additional, Tsui, Albert K.Y., additional, Thorlacius, Laurel, additional, Aakre, Kristin M., additional, Raizman, Joshua E., additional, Fung, Angela W.S., additional, Humphries, Karin H., additional, Arnoldo, Saranya, additional, Bhayana, Vipin, additional, Djiana, Rose, additional, Beriault, Daniel R., additional, St-Cyr, Julie, additional, Booth, Ronald A., additional, Blank, David W., additional, Sivilotti, Marco L.A., additional, and Jaffe, Allan S., additional more...

Published
2024
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42. Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review

Author

Granton, David, primary, Rodrigues, Myanca, additional, Raparelli, Valeria, additional, Honarmand, Kimia, additional, Agarwal, Arnav, additional, Friedrich, Jan O, additional, Perna, Benedetta, additional, Spaggiari, Riccardo, additional, Fortunato, Valeria, additional, Risdonne, Gianluca, additional, Kho, Michelle, additional, VanderKaay, Sandra, additional, Chaudhuri, Dipayan, additional, Gomez-Builes, Carolina, additional, D'Aragon, Frédérick, additional, Wiseman, Daniel, additional, Lau, Vincent Issac, additional, Lin, Celina, additional, Reid, Julie, additional, Trivedi, Vatsal, additional, Prakash, Varuna, additional, Belley-Cote, Emilie, additional, Al Mandhari, Maha, additional, Thabane, Lehana, additional, Pilote, Louise, additional, and Burns, Karen E A, additional more...

Published
2024
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43. Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials

Author

Lawati, Kumait Al, Sharif, Sameer, Maqbali, Said Al, Rimawi, Hussein Al, Petrosoniak, Andrew, Belley-Cote, Emilie P., and Sharma, Sunjay V.

Subjects
Injuries, Mortality -- Canada, Tranexamic acid, Brain injuries, Brain -- Injuries
Abstract

Author(s): Kumait Al Lawati [sup.1] [sup.2] [sup.3], Sameer Sharif [sup.1] [sup.2], Said Al Maqbali [sup.1] [sup.3], Hussein Al Rimawi [sup.1], Andrew Petrosoniak [sup.4], Emilie P. Belley-Cote [sup.2] [sup.5], Sunjay V. [...], Purpose With the publication of a large randomized-controlled trial (RCT) suggesting that tranexamic acid (TXA) may improve head-injury-related deaths, we aimed to determine the safety and efficacy of TXA in acute traumatic brain injury (TBI). Methods In this systematic review and meta-analysis, we searched MEDLINE, PubMed, EMBASE, CINHAL, ACPJC, Google Scholar, and unpublished sources from inception until June 24, 2020 for randomized-controlled trials comparing TXA and placebo in adults and adolescents ([greater than or equal to] 15 years of age) with acute TBI. We screened studies and extracted summary estimates independently and in duplicate. We assessed the quality of evidence using the grading of recommendations assessment, development, and evaluation approach. This study is registered with PROSPERO (CRD42020164232). Results Nine RCTs enrolled 14,747 patients. Compared to placebo, TXA had no effect on mortality (RR 0.95; 95% CI 0.88-1.02; RD 1.0% reduction; 95% CI 2.5% reduction to 0.4% increase, moderate certainty) or disability assessed by the Disability Rating Scale (MD, - 0.18 points; 95% CI - 0.43 to 0.08; moderate certainty). TXA may reduce hematoma expansion on subsequent imaging (RR 0.77; 95% CI 0.58-1.03, RD 3.6%, 95% CI 6.6% reduction to 0.5% increase, low certainty). Risks of adverse events (all moderate, low, or very low certainty) were similar between placebo and TXA. Conclusions In patients with acute TBI, TXA probably has no effect on mortality or disability. TXA may decrease hematoma expansion on subsequent imaging; however, this outcome is likely of less importance to patients. The use of TXA probably does not increase the risk of adverse events. more...

Published
2021
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45. Small-volume blood sample collection tubes in adult intensive care units:A rapid practice guideline

Author

Callum, Jeannie, Putowski, Zbignew, Alhazzani, Waleed, Belley-Cote, Emilie, Møller, Morten Hylander, Curry, Nicola, Al Duhailib, Zainab, Fung, Mark, Giocobbo, Louise, Granholm, Anders, Louw, Vernon, Maybohm, Patrick, Muller, Marcella, Nielsen, Nathan, Oleschuk, Curtis, Raza, Sheharyar, Scruth, Elizabeth, Siegal, Deborah, Stanworth, Simon J., Vlaar, Alexander P. J., White, Micheline, Oczkowski, Simon, Callum, Jeannie, Putowski, Zbignew, Alhazzani, Waleed, Belley-Cote, Emilie, Møller, Morten Hylander, Curry, Nicola, Al Duhailib, Zainab, Fung, Mark, Giocobbo, Louise, Granholm, Anders, Louw, Vernon, Maybohm, Patrick, Muller, Marcella, Nielsen, Nathan, Oleschuk, Curtis, Raza, Sheharyar, Scruth, Elizabeth, Siegal, Deborah, Stanworth, Simon J., Vlaar, Alexander P. J., White, Micheline, and Oczkowski, Simon more...

Abstract

Background This Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) provides an evidence-based recommendation to address the question: in adult patients in intensive care units (ICUs), should we use small-volume or conventional blood collection tubes? Methods We included 23 panelists in 8 countries and assessed and managed financial and intellectual conflicts of interest. Methodological support was provided by the Guidelines in Intensive Care, Development, and Evaluation (GUIDE) group. We conducted a systematic review, including evidence from observational and randomized studies. Using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, we evaluated the certainty of evidence and developed recommendations using the Evidence-to-Decision framework. Results We identified 8 studies (1 cluster and 2 patient-level randomized trials; 5 observational studies) comparing small-volume to conventional tubes. We had high certainty evidence that small-volume tubes reduce daily and cumulative blood sampling volume; and moderate certainty evidence that they reduce the risk of transfusion and mean number of red blood cell units transfused, but these estimates were limited by imprecision. We had high certainty that small-volume tubes have a similar rate of specimens with insufficient quantity. The panel considered that the desirable effects of small-volume tubes outweigh the undesirable effects, are less wasteful of resources, and are feasible, as demonstrated by successful implementation across multiple countries, although there are upfront implementation costs to validate small-volume tubes on laboratory instrumentation. Conclusion This ICM-RPG panel made a strong recommendation for the use of small-volume sample collection tubes in adult ICUs based on overall moderate certainty evidence., Background: This Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) provides an evidence-based recommendation to address the question: in adult patients in intensive care units (ICUs), should we use small-volume or conventional blood collection tubes?. Methods: We included 23 panelists in 8 countries and assessed and managed financial and intellectual conflicts of interest. Methodological support was provided by the Guidelines in Intensive Care, Development, and Evaluation (GUIDE) group. We conducted a systematic review, including evidence from observational and randomized studies. Using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, we evaluated the certainty of evidence and developed recommendations using the Evidence-to-Decision framework. Results: We identified 8 studies (1 cluster and 2 patient-level randomized trials; 5 observational studies) comparing small-volume to conventional tubes. We had high certainty evidence that small-volume tubes reduce daily and cumulative blood sampling volume; and moderate certainty evidence that they reduce the risk of transfusion and mean number of red blood cell units transfused, but these estimates were limited by imprecision. We had high certainty that small-volume tubes have a similar rate of specimens with insufficient quantity. The panel considered that the desirable effects of small-volume tubes outweigh the undesirable effects, are less wasteful of resources, and are feasible, as demonstrated by successful implementation across multiple countries, although there are upfront implementation costs to validate small-volume tubes on laboratory instrumentation. Conclusion: This ICM-RPG panel made a strong recommendation for the use of small-volume sample collection tubes in adult ICUs based on overall moderate certainty evidence. more...

Published
2024

46. European Society of Intensive Care Medicine clinical practice guideline on fluid therapy in adult critically ill patients. Part 1:the choice of resuscitation fluids

Author

Arabi, Yaseen M., Belley-Cote, Emilie, Carsetti, Andrea, De Backer, Daniel, Donadello, Katia, Juffermans, Nicole P., Hammond, Naomi, Laake, Jon Henrik, Liu, Dawei, Maitland, Kathryn, Messina, Antonio, Møller, Morten Hylander, Poole, Daniele, Mac Sweeney, Rob, Vincent, Jean-Louis, Zampieri, Fernando G., AlShamsi, Fayez, Arabi, Yaseen M., Belley-Cote, Emilie, Carsetti, Andrea, De Backer, Daniel, Donadello, Katia, Juffermans, Nicole P., Hammond, Naomi, Laake, Jon Henrik, Liu, Dawei, Maitland, Kathryn, Messina, Antonio, Møller, Morten Hylander, Poole, Daniele, Mac Sweeney, Rob, Vincent, Jean-Louis, Zampieri, Fernando G., and AlShamsi, Fayez more...

Abstract

Purpose This is the first of three parts of the clinical practice guideline from the European Society of Intensive Care Medicine (ESICM) on resuscitation fluids in adult critically ill patients. This part addresses fluid choice and the other two will separately address fluid amount and fluid removal. Methods This guideline was formulated by an international panel of clinical experts and methodologists. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology was applied to evaluate the certainty of evidence and to move from evidence to decision. Results For volume expansion, the guideline provides conditional recommendations for using crystalloids rather than albumin in critically ill patients in general (moderate certainty of evidence), in patients with sepsis (moderate certainty of evidence), in patients with acute respiratory failure (very low certainty of evidence) and in patients in the perioperative period and patients at risk for bleeding (very low certainty of evidence). There is a conditional recommendation for using isotonic saline rather than albumin in patients with traumatic brain injury (very low certainty of evidence). There is a conditional recommendation for using albumin rather than crystalloids in patients with cirrhosis (very low certainty of evidence). The guideline provides conditional recommendations for using balanced crystalloids rather than isotonic saline in critically ill patients in general (low certainty of evidence), in patients with sepsis (low certainty of evidence) and in patients with kidney injury (very low certainty of evidence). There is a conditional recommendation for using isotonic saline rather than balanced crystalloids in patients with traumatic brain injury (very low certainty of evidence). There is a conditional recommendation for using isotonic crystalloids rather than small-volume hypertonic crystalloids in critically ill patients in general (very low cert, Purpose: This is the first of three parts of the clinical practice guideline from the European Society of Intensive Care Medicine (ESICM) on resuscitation fluids in adult critically ill patients. This part addresses fluid choice and the other two will separately address fluid amount and fluid removal. Methods: This guideline was formulated by an international panel of clinical experts and methodologists. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology was applied to evaluate the certainty of evidence and to move from evidence to decision. Results: For volume expansion, the guideline provides conditional recommendations for using crystalloids rather than albumin in critically ill patients in general (moderate certainty of evidence), in patients with sepsis (moderate certainty of evidence), in patients with acute respiratory failure (very low certainty of evidence) and in patients in the perioperative period and patients at risk for bleeding (very low certainty of evidence). There is a conditional recommendation for using isotonic saline rather than albumin in patients with traumatic brain injury (very low certainty of evidence). There is a conditional recommendation for using albumin rather than crystalloids in patients with cirrhosis (very low certainty of evidence). The guideline provides conditional recommendations for using balanced crystalloids rather than isotonic saline in critically ill patients in general (low certainty of evidence), in patients with sepsis (low certainty of evidence) and in patients with kidney injury (very low certainty of evidence). There is a conditional recommendation for using isotonic saline rather than balanced crystalloids in patients with traumatic brain injury (very low certainty of evidence). There is a conditional recommendation for using isotonic crystalloids rather than small-volume hypertonic crystalloids in critically ill patients in general (very low certainty of evidence). Conc more...

Published
2024

47. Higher versus lower oxygenation targets in adult ICU patients: A rapid practice guideline

Author

Medische Staf Intensive Care, Infection & Immunity, Møller, Morten Hylander, Granholm, Anders, Al Duhailib, Zainab, Alhazzani, Waleed, Belley-Cote, Emilie, Oczkowski, Simon, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Sjövall, Fredrik, Butler, Ethan, Zampieri, Fernando G., Mac Sweeney, Rob, Derde, Lennie P.G., Ruzycki-Chadwick, Ally, Mer, Mervyn, Burns, Karen E.A., Ergan, Begüm, Al-Fares, Abdulrahman, Sjoding, Michael W., Valley, Thomas S., Rasmussen, Bodil S., Schjørring, Olav L., Prescott, Hallie C., Medische Staf Intensive Care, Infection & Immunity, Møller, Morten Hylander, Granholm, Anders, Al Duhailib, Zainab, Alhazzani, Waleed, Belley-Cote, Emilie, Oczkowski, Simon, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Sjövall, Fredrik, Butler, Ethan, Zampieri, Fernando G., Mac Sweeney, Rob, Derde, Lennie P.G., Ruzycki-Chadwick, Ally, Mer, Mervyn, Burns, Karen E.A., Ergan, Begüm, Al-Fares, Abdulrahman, Sjoding, Michael W., Valley, Thomas S., Rasmussen, Bodil S., Schjørring, Olav L., and Prescott, Hallie C. more...

Published
2024

48. GRADE pearls and pitfalls - Part 1:Systematic reviews and meta-analyses

Author

Al Duhailib, Zainab, Granholm, Anders, Alhazzani, Waleed, Oczkowski, Simon, Belley-Cote, Emilie, Møller, Morten Hylander, Al Duhailib, Zainab, Granholm, Anders, Alhazzani, Waleed, Oczkowski, Simon, Belley-Cote, Emilie, and Møller, Morten Hylander more...

Abstract

Background: The Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach is used to assess the certainty of evidence in systematic reviews and meta-analyses. Methods: We describe how the GRADE approach is used in systematic reviews and meta-analyses, including key points and examples. This overview is aimed at clinicians and researchers who are, or plan to be, involved in the development or assessment of systematic reviews with meta-analyses using GRADE. Results: We outline how the certainty of evidence is assessed, how the evidence is summarized using GRADE evidence profiles or summary of findings tables, how the results are communicated, and we discuss challenges, advantages, and disadvantages with using GRADE. Conclusions: This overview aims to provide an overview of how GRADE is used in systematic reviews and meta-analyses, and may be used by systematic review developers, methodologists, and evidence end-users. more...

Published
2024

49. Higher versus lower oxygenation targets in adult ICU patients:A rapid practice guideline

Author

Møller, Morten Hylander, Granholm, Anders, Al Duhailib, Zainab, Alhazzani, Waleed, Belley-Cote, Emilie, Oczkowski, Simon, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Sjövall, Fredrik, Butler, Ethan, Zampieri, Fernando G., Mac Sweeney, Rob, Derde, Lennie P.G., Ruzycki-Chadwick, Ally, Mer, Mervyn, Burns, Karen E.A., Ergan, Begüm, Al-Fares, Abdulrahman, Sjoding, Michael W., Valley, Thomas S., Rasmussen, Bodil S., Schjørring, Olav L., Prescott, Hallie C., Møller, Morten Hylander, Granholm, Anders, Al Duhailib, Zainab, Alhazzani, Waleed, Belley-Cote, Emilie, Oczkowski, Simon, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Sjövall, Fredrik, Butler, Ethan, Zampieri, Fernando G., Mac Sweeney, Rob, Derde, Lennie P.G., Ruzycki-Chadwick, Ally, Mer, Mervyn, Burns, Karen E.A., Ergan, Begüm, Al-Fares, Abdulrahman, Sjoding, Michael W., Valley, Thomas S., Rasmussen, Bodil S., Schjørring, Olav L., and Prescott, Hallie C. more...

Abstract

The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) was to provide evidence-based clinical guidance about the use of higher versus lower oxygenation targets for adult patients in the intensive care unit (ICU). The guideline panel comprised 27 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. We adhered to the methodology for trustworthy clinical practice guidelines, including the use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and used the Evidence-to-Decision framework to generate recommendations. A recently published updated systematic review and meta-analysis constituted the evidence base. Through teleconferences and web-based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients' values and preferences, costs and resources, equity, feasibility, acceptability, and research priorities. The updated systematic review and meta-analysis included data from 17 randomized clinical trials with 10,248 participants. There was little to no difference between the use of higher versus lower oxygenation targets for all outcomes with available data, including all-cause mortality, serious adverse events, stroke, functional outcomes, cognition, and health-related quality of life (very low certainty of evidence). The panel felt that values and preferences, costs and resources, and equity favored the use of lower oxygenation targets. The ICM-RPG panel issued one conditional recommendation against the use of higher oxygenation targets: “We suggest against the routine use of higher oxygenation targets in adult ICU patients (conditional recommendation, very low certainty of evidence). Remark: an oxygenation target of SpO2 88%–92% or PaO2 8 kPa/60 mmHg is relevant and safe for most adult ICU patients.”, The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) was to provide evidence-based clinical guidance about the use of higher versus lower oxygenation targets for adult patients in the intensive care unit (ICU). The guideline panel comprised 27 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. We adhered to the methodology for trustworthy clinical practice guidelines, including the use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and used the Evidence-to-Decision framework to generate recommendations. A recently published updated systematic review and meta-analysis constituted the evidence base. Through teleconferences and web-based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients' values and preferences, costs and resources, equity, feasibility, acceptability, and research priorities. The updated systematic review and meta-analysis included data from 17 randomized clinical trials with 10,248 participants. There was little to no difference between the use of higher versus lower oxygenation targets for all outcomes with available data, including all-cause mortality, serious adverse events, stroke, functional outcomes, cognition, and health-related quality of life (very low certainty of evidence). The panel felt that values and preferences, costs and resources, and equity favored the use of lower oxygenation targets. The ICM-RPG panel issued one conditional recommendation against the use of higher oxygenation targets: “We suggest against the routine use of higher oxygenation targets in adult ICU patients (conditional recommendation, very low certainty of evidence). Remark: an oxygenation target of SpO2 88%–92% or PaO2 8 kPa/60 mmHg is relevant and safe for most adult ICU patients.”. more...

Published
2024

50. How to Assess a Prognostic Study

Author

Gupta, Saurabh, Kim, Kevin, Belley-Côté, Emilie, Whitlock, Richard P., Thoma, Achilles, editor, Sprague, Sheila, editor, Voineskos, Sophocles H., editor, and Goldsmith, Charles H., editor

Published
2019
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