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1. Reperfusion therapies in patients with acute ischaemic stroke and atrial fibrillation: data on safety and effectiveness from a multi-centre cohort study

Author

Cancelloni, Virginia, Buratti, Mariachiara, Tsivgoulis, Georgios, Furie, Karen L., Tadi, Prasanna, Caso, Valeria, Becattini, Cecilia, Agnelli, Giancarlo, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Alberti, Andrea, Venti, Michele, de Magistris, Ilaria Leone, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria G., Cimini, Ludovica A., Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Sohn, Sung-I. I., Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Sagris, Dimitrios, Adamou, Anastasia, Vadikolias, Kostantinos, Palaiodimou, Lina, Chondrogianni, Maria, Mumoli, Nicola, Galati, Franco, Sacco, Simona, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Mancuso, Michelangelo, Orlandi, Giovanni, Pascarella, Rosario, Tassinari, Tiziana, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Lettieri, Federica, Giuntini, Martina, Lotti, Enrico M., Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Halvatsiotis, Panagiotis, Monaco, Serena, Baronello, Mario M., Csiba, Laszlò, Szabò, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars P., Kepplinger, Jessica, Deleu, Dirk, Gourbali, Vanessa, Yaghi, Shadi, and Paciaroni, Maurizio

Published
2024
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3. Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes

Author

Marvardi, Michele, primary, Ferrante, Mario, additional, Paciaroni, Maurizio, additional, Abdul-Rahim, Azmil H, additional, Tsivgoulis, Georgios, additional, Seiffge, David J, additional, Engelter, Stefan T, additional, Lyrer, Philippe A., additional, Polymeris, Alexandros A, additional, Dittrich, Tolga D, additional, Cancelloni, Virginia, additional, Zietz, Annaelle, additional, De Marchis, Gian Marco, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Vanacker, Peter, additional, Zuurbier, Susanna M., additional, Yperzeele, Laetitia, additional, Loos, Caroline MJ, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Becattini, Cecilia, additional, Pascarella, Rosario, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra Sharma, additional, Schomer, Ashley, additional, Mac Grory, Brian, additional, Jayaraman, Mahesh V, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne A, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Leone De Magistris, Ilaria, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D'Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Adamou, Anastasia, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, D'agliano, Roberto, additional, Baldini, Marco, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Halvatsiotis, Panagiotis, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, lanari, alessia, additional, Tatlisumak, Turgut, additional, Acciarresi, Monica, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung-Il, additional, Mumoli, Nicola, additional, Cararra, Davide, additional, Maccarrone, Miriam, additional, Galati, Franco, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Corea, Francesco, additional, Bellesini, Marta, additional, Karapanayiotides, Theodore, additional, Csiba, Laszlo, additional, Szabo, Lilla, additional, Imberti, Davide, additional, Pieroni, Alessio, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Doronin, Boris, additional, Volodina, Vera Alexandrovna, additional, Agnelli, Giancarlo, additional, Deleu, Dirk, additional, Bonetti, Bruno, additional, Gentile, Luana, additional, Reale, Giuseppe, additional, Caliandro, Pietro, additional, Morotti, Andrea, additional, Vannucchi, Vieri, additional, Padroni, Marina, additional, Letteri, Federica, additional, Magoni, Mauro, additional, Tiseo, Cindy, additional, Rigatelli, Alberto, additional, Zauli, Aurelia, additional, Bossi, Francesco, additional, and Caso, Valeria, additional

Published
2024
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7. Safety of Anticoagulation in Patients Treated With Urgent Reperfusion for Ischemic Stroke Related to Atrial Fibrillation

Author

Giustozzi, Michela, Acciarresi, Monica, Agnelli, Giancarlo, Caso, Valeria, Bandini, Fabio, Tsivgoulis, Georgios, Yaghi, Shadi, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, D’Amore, Cataldo, Giulia Mosconi, Maria, Anna Cimini, Ludovica, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Athanasakis, George, Makaritsis, Konstantinos, Karagkiozi, Efstathia, Vadikolias, Konstantinos, Liantinioti, Chrissoula, Theodorou, Aikaterini, Halvatsiotis, Panagiotis, Mumoli, Nicola, Galati, Franco, Sacco, Simona, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Lanari, Alessia, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Ferrari, Elena, Ulivi, Leonardo, Orlandi, Giovanni, Giannini, Nicola, Tassinari, Tiziana, Luisa De Lodovici, Maria, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Maria Lotti, Enrico, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Maimone Baronello, Mario, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Barlinn, Jessica, Deleu, Dirk, Gourbali, Vanessa, Paciaroni, Maurizio, and Masotti, Luca

Published
2020
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8. Anticoagulation After Stroke in Patients With Atrial Fibrillation: To Bridge or Not With Low-Molecular-Weight Heparin?

Author

Altavilla, Riccardo, Caso, Valeria, Bandini, Fabio, Agnelli, Giancarlo, Tsivgoulis, Georgios, Yaghi, Shadi, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Giulia Mosconi, Maria, Anna Cimini, Ludovica, Fusaro, Jessica, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Athanasakis, George, Makaritsis, Konstantinos, Karagkiozi, Efstathia, Vadikolias, Konstantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Lanari, Alessia, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Ulivi, Leonardo, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, De Lodovici, Maria Luisa, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, D’Anna, Sebastiano, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Maria Lotti, Enrico, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Maimone Baronello, Mario, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Gourbali, Vanessa, and Paciaroni, Maurizio

Published
2019
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9. The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Mosconi, Maria Giulia, Giustozzi, Michela, Tsivgoulis, Georgios, Seiffge, David Julian, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna M., Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, De Magistris, Ilaria Leone, Cancelloni, Virginia, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Moci, Marco, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Morotti, Andrea, Magoni, Mauro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Halvatsiotis, Panagiotis, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Baronello, Mario Maimone, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and De Marchis, Gian Marco

Abstract

Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of ischemic and severe bleeding events in ischemic stroke patients having both AF and reduced ejection fraction (rEF) (⩽40%), compared to ischemic stroke patients with AF but without rEF.Methods: We performed a retrospective analysis that drew data from prospective studies. The primary outcome was the composite of either ischemic (stroke or systemic embolism), or hemorrhagic events (symptomatic intracranial bleeding and severe extracranial bleeding).Results: The cohort for this analysis comprised 3477 patients with ischemic stroke and AF, of which, 643 (18.3%) had also rEF. After a mean follow-up of 7.5 ± 9.1 months, 375 (10.8%) patients had 382 recorded outcome events, for an annual rate of 18.0%. While the number of primary outcome events in patients with rEF was 86 (13.4%), compared to 289 (10.2%) for the patients without rEF; on multivariable analysis rEF was not associated with the primary outcome (OR 1.25; 95% CI 0.84–1.88). At the end of follow-up, 321 (49.9%) patients with rEF were deceased or disabled (mRS ⩾3), compared with 1145 (40.4%) of those without rEF; on multivariable analysis, rEF was correlated with mortality or disability (OR 1.35; 95% CI 1.03–1.77).Conclusions: In patients with ischemic stroke and AF, the presence of rEF was not associated with the composite outcome of ischemic or hemorrhagic events over short-term follow-up but was associated with increased mortality or disability.

Published
2023
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10. Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy

Author

Caliandro, Pietro, Cancelloni, Virginia, Marco, Moci, Reale, Giuseppe, Zauli, Aurelia, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Calabresi, Paolo, Giulia Mosconi, Maria, Giustozzi, Michela, Tsivgoulis, Georgios, Julian Seiffge, David, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Marco De Marchis, Gian, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, McTaggart, Ryan, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Maria Lotti, Enrico, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Leone De Magistris, Ilaria, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Emanuele Saggese, Carlo, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Chiara Caselli, Maria, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Halvatsiotis, Panagiotis, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Poli, Loris, Magoni, Mauro, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Girardi, Laura, Maimone Baronello, Mario, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and Paciaroni, Maurizio

Abstract

Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulation therapy (OAC/AP). Our study aims to evaluate the safety and efficacy of OAC/AP therapy as secondary prevention in people with AF and ischaemic stroke.Patients and methods: We performed a post-hoc analysis of pooled individual data from multicenter prospective cohort studies and compared outcomes in the OAC/AP cohort and patients on DOAC/VKA anticoagulation alone (OAC cohort). Primary outcome was a composite of ischaemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischaemic and haemorrhagic events considered separately. A multivariable logistic regression analysis was performed to identify independent predictors for outcome events. To compare the risk of outcome events between the two cohorts, the relation between the survival function and the set of explanatory variables were calculated by Cox proportional hazard models and the results were reported as adjusted hazard ratios (HR). Finally another analysis was performed to compare the overall risk of outcome events in both OAC/AP and OAC cohorts after propensity score matching (PSM).Results: During a mean follow-up time of 7.5 ± 9.1 months (median follow-up time 3.5 months, interquartile range ±3), 2284 stroke patients were on oral anticoagulants and 215 were on combined therapy. The multivariable model demonstrated that the composite outcome is associated with age (OR: 1.03, 95% CI: 1.01–1.04 for each year increase) and concomitant antiplatelet therapy (OR: 2.2, 95% CI: 1.48–3.27), the ischaemic outcome with congestive heart failure (OR: 1.55, 95% CI: 1.02–2.36) and concomitant antiplatelet therapy (OR: 1.93, 95% CI: 1.19–3.13) and the haemorrhagic outcome with age (OR: 1.03, 95% CI: 1.01–1.06 for each year increase), alcoholism (OR: 2.15, 95% CI: 1.06–4.39) and concomitant antiplatelet therapy (OR: 2.22, 95% CI: 1.23–4.02). Cox regression demonstrated a higher rate of the composite outcome (hazard ratio of 1.93 [95% CI, 1.35–2.76]), ischaemic events (HR: 2.05 [95% CI: 1.45–2.87]) and bleeding outcomes (HR: 1.90 [95% CI, 1.06–3.40]) in OAC/AP cohort. After PSM analysis, the composite outcome remained more frequent in people treated with OAC + AP (RR: 1.70 [95% CI, 1.05–2.74]).Discussion: Secondary prevention with combination of oral anticoagulant and antiplatelet therapy after ischaemic stroke was associated with worse outcomes in our cohort.Conclusion: Further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischaemic stroke in patients with atrial fibrillation.

Published
2023
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11. Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema: The ALESSA Score Study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Tsivgoulis, Georgios, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Falocci, Nicola, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria Giulia, Cimini, Ludovica Anna, Procopio, Antonio, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Colombo, Giovanna, Silvestrelli, Giorgio, Ciccone, Alfonso, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, De Lodovici, Maria Luisa, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, D’Anna, Sebastiano, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Lotti, Enrico Maria, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Baronello, Mario Maimone, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Gourbali, Vanessa, and Yaghi, Shadi

Published
2017
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12. Practical “1-2-3-4-Day” Rule for Starting Direct Oral Anticoagulants After Ischemic Stroke With Atrial Fibrillation: Combined Hospital-Based Cohort Study

Author

Kimura, Shunsuke, primary, Toyoda, Kazunori, additional, Yoshimura, Sohei, additional, Minematsu, Kazuo, additional, Yasaka, Masahiro, additional, Paciaroni, Maurizio, additional, Werring, David J., additional, Yamagami, Hiroshi, additional, Nagao, Takehiko, additional, Yoshimura, Shinichi, additional, Polymeris, Alexandros, additional, Zietz, Annaelle, additional, Engelter, Stefan T., additional, Kallmünzer, Bernd, additional, Cappellari, Manuel, additional, Chiba, Tetsuya, additional, Yoshimoto, Takeshi, additional, Shiozawa, Masayuki, additional, Kitazono, Takanari, additional, Koga, Masatoshi, additional, Todo, Kenichi, additional, Kimura, Kazumi, additional, Yagita, Yoshiki, additional, Furui, Eisuke, additional, Itabashi, Ryo, additional, Terasaki, Tadashi, additional, Shiokawa, Yoshiaki, additional, Hirano, Teruyuki, additional, Kamiyama, Kenji, additional, Nakagawara, Jyoji, additional, Takizawa, Shunya, additional, Homma, Kazunari, additional, Okuda, Satoshi, additional, Okada, Yasushi, additional, Tokunaga, Keisuke, additional, Kameda, Tomoaki, additional, Kario, Kazuomi, additional, Nagakane, Yoshinari, additional, Hasegawa, Yasuhiro, additional, Akiyama, Hisanao, additional, Shibuya, Satoshi, additional, Mochizuki, Hiroshi, additional, Ito, Yasuhiro, additional, Nakashima, Takahiro, additional, Matsuoka, Hideki, additional, Takamatsu, Kazuhiro, additional, Nishiyama, Kazutoshi, additional, Sato, Shoichiro, additional, Arihiro, Shoji, additional, Inoue, Manabu, additional, Takagi, Masahito, additional, Tanaka, Kanta, additional, Nagatsuka, Kazuyuki, additional, Yamaguchi, Takenori, additional, Hashimoto, Yoichiro, additional, Houkin, Kiyohiro, additional, Kitagawa, Kazuo, additional, Matsumoto, Masayasu, additional, Tanahashi, Norio, additional, Terayama, Yasuo, additional, Uchiyama, Shinichiro, additional, Mori, Etsuro, additional, Furukawa, Yutaka, additional, Kimura, Takeshi, additional, Kumon, Yoshiaki, additional, Nagata, Ken, additional, Nogawa, Shigeru, additional, Sakamoto, Tomohiro, additional, Hirai, Toshinori, additional, Kudo, Kohsuke, additional, Sasaki, Makoto, additional, Kobayashi, Shotai, additional, Hamasaki, Toshimitsu, additional, Giustozzi, Michela, additional, Acciarresi, Monica, additional, Agnelli, Giancarlo, additional, Caso, Valeria, additional, Bandini, Fabio, additional, Tsivgoulis, Georgios, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Becattini, Cecilia, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil H, additional, Lees, Kennedy R, additional, Alberti, Andrea, additional, Venti, Michele, additional, D’Amore, Cataldo, additional, Giulia Mosconi, Maria, additional, Anna Cimini, Ludovica, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Vannucchi, Vieri, additional, Sohn, Sung-Il, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Ntaios, George, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, Karagkiozi, Efstathia, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrissoula, additional, Chondrogianni, Maria, additional, Mumoli, Nicola, additional, Galati, Franco, additional, Sacco, Simona, additional, Tiseo, Cindy, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Lanari, Alessia, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Ulivi, Leonardo, additional, Orlandi, Giovanni, additional, Giannini, Nicola, additional, Tassinari, Tiziana, additional, De Lodovici, Maria Luisa, additional, Rueckert, Christina, additional, Baldi, Antonio, additional, Toni, Danilo, additional, Letteri, Federica, additional, Giuntini, Martina, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Pieroni, Alessio, additional, Kargiotis, Odysseas, additional, Karapanayiotides, Theodore, additional, Monaco, Serena, additional, Baronello, Mario Maimone, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Michel, Patrik, additional, Vanacker, Peter, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Gourbali, Vanessa, additional, Masotti, Luca, additional, Parry-Jones, Adrian, additional, Patterson, Chris, additional, Price, Christopher, additional, Elmarimi, Abduelbaset, additional, Parry, Anthea, additional, Nallasivam, Arumug, additional, Mohd Nor, Azlisham, additional, Esis, Bernard, additional, Bruce, David, additional, Roffe, Christine, additional, Holmes, Clare, additional, Cohen, David, additional, Hargroves, David, additional, Mangion, David, additional, Chadha, Dinesh, additional, Vahidassr, Djamil, additional, Manawadu, Dulka, additional, Giallombardo, Elio, additional, Warburton, Elizabeth, additional, Flossman, Enrico, additional, Gunathilagan, Gunaratam, additional, Proschel, Harald, additional, Emsley, Hedley, additional, Anwar, Ijaz, additional, Okwera, James, additional, Putterill, Janet, additional, O’Connell, Janice, additional, Bamford, John, additional, Corrigan, John, additional, Scott, Jon, additional, Birns, Jonathan, additional, Kee, Karen, additional, Saastamoinen, Kari, additional, Pasco, Kath, additional, Dani, Krishna, additional, Sekaran, Lakshmanan, additional, Choy, Lillian, additional, Iveson, Liz, additional, Mamun, Maam, additional, Sajid, Mahmud, additional, Cooper, Martin, additional, Burn, Matthew, additional, Smith, Matthew, additional, Power, Michael, additional, Davis, Michelle, additional, Smyth, Nigel, additional, Veltkamp, Roland, additional, Sharma, Pankaj, additional, Guyler, Paul, additional, O’Mahony, Paul, additional, Wilkinson, Peter, additional, Datta, Prabel, additional, Aghoram, Prasanna, additional, Marsh, Rachel, additional, Luder, Robert, additional, Meenakishundaram, Sanjeevikumar, additional, Subramonian, Santhosh, additional, Leach, Simon, additional, Ispoglou, Sissi, additional, Andole, Sreeman, additional, England, Timothy, additional, Manoj, Aravindakshan, additional, Harrington, Frances, additional, Rehman, Habib, additional, Sword, Jane, additional, Staals, Julie, additional, Mahawish, Karim, additional, Harkness, Kirsty, additional, Shaw, Louise, additional, McCormich, Michael, additional, Sprigg, Nikola, additional, Mansoor, Syed, additional, Krishnamurthy, Vinodh, additional, Lyrer, Philippe A, additional, Bonati, Leo H, additional, Seiffge, David J, additional, Traenka, Christopher, additional, Peters, Nils, additional, De Marchis, Gian Marco, additional, Thilemann, Sebastian, additional, Avramiotis, Nikolaos S, additional, Gensicke, Henrik, additional, Hert, Lisa, additional, Wagner, Benjamin, additional, Schaub, Fabian, additional, Meya, Louisa, additional, Fladt, Joachim, additional, Dittrich, Tolga, additional, Fisch, Urs, additional, Bonetti, Bruno, additional, Tomelleri, Giampaolo, additional, Micheletti, Nicola, additional, Zivelonghi, Cecilia, additional, Emiliani, Andrea, additional, Macha, Kosmas, additional, Siedler, Gabriela, additional, Stoll, Svenja, additional, Wang, Ruihao, additional, Volbers, Bastian, additional, Schwab, Stefan, additional, Haupenthal, David, additional, and Gaßmann, Luise, additional

Published
2022
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13. Timing of initiation of oral anticoagulants in patients with acute ischemic stroke and atrial\ud fibrillation comparing posterior and anterior circulation strokes

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Giustozzi, Michela, Tsivgoulis, Georgios, Yaghi, Shadi, MacGrory, Brian, Furie, Karen L., Tadi, Prasanna, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D'Amore, Cataldo, Mosconi, Maria Guilia, Bognini, Valentina, Cappellari, Manuel, Rigatelli, Alberto, Bonetti, Bruno, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Grifoni, Elisa, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Athanasakis, George, Makaritsis, Konstantinos, Karagkiozi, Efstathia, Vadikolias, Konstantinos, Liantinioti, Chrissoula, Palaiodimou, Lina, Mumoli, Nicola, Porta, Cesare, Galati, Franco, Sacco, Simona, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Caselli, Maria Chiara, Maccarrone, Miriam, Ulivi, Leonardo, Orlandi, Giovanni, Giannini, Nicola, Tassinari, Tiziana, De Lodovici, Maria Luisa, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Gentile, Luana, Letteri, Federica, Giuntini, Martina, Lotti, Enrico Maria, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Mannino, Marina, Maimone Baronello, Mario, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Schirinzi, Erika, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Eskandari, Ashraf, Vanacker, Peter, Barlinn, Kristian, Barlinn, Jessica, Deleu, Dirk, Gourbali, Vanessa, and Caso, Valeria

Abstract

Background: The aim of this study in patients with acute posterior ischemic stroke (PS) and atrial fibrillation (AF) were to evaluate the risks of recurrent ischemic event and severe bleeding and these risks in relation with oral anticoagulant therapy (OAT) and its timing.\ud \ud Methods: Patients with PS were prospectively included; the outcome events of these patients were compared with those of patients with anterior stroke (AS) which were taken from previous registries. The primary outcome was the composite of: stroke recurrence, TIA, symptomatic systemic embolism, symptomatic cerebral bleeding and major extracranial bleeding occurring within 90 days from acute stroke.\ud \ud Results: A total of 2,470 patients were available for the analysis: 473 (19.1%) with PS and 1,997 (80.9%) AS. Over 90 days, 213 (8.6%) primary outcome events were recorded: 175 (8.7%) in patients with AS and 38 (8.0%) in those with PS. In patients who initiated OAT within 2 days, the primary outcome occurred in 5 out of 95 patients (5.3%) with PS compared to 21 out of 373 patients (4.3%) with AS (OR 1.07; 95% CI 0.39-2.94). In patients who initiated OAT between days 3 and 7, the primary outcome occurred in 3 out of 103 patients (2.9%) with PS compared to 26 out of 490 patients (5.3%) with AS (OR 0.54; 95% CI 0.16-1.80).\ud \ud Conclusions: Patients with posterior or anterior stroke and AF appear to have similar risks of\ud ischemic or hemorrhagic events at 90 days with no difference concerning the timing of initiation of OAT.

Published
2020

14. External validation of the YEARS diagnostic algorithm for suspected pulmonary embolism.

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service des urgences, Eddy, Maggie, Robert-Ebadi, Helia, Richardson, Lydia, Bellesini, Marta, Verschuren, Frank, Moumneh, Thomas, Meyer, Guy, Righini, Marc, Le Gal, Grégoire, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service des urgences, Eddy, Maggie, Robert-Ebadi, Helia, Richardson, Lydia, Bellesini, Marta, Verschuren, Frank, Moumneh, Thomas, Meyer, Guy, Righini, Marc, and Le Gal, Grégoire

Abstract

BACKGROUND: Validated diagnostic algorithms are used to manage patients with suspected pulmonary embolism (PE). The recently published YEARS study proposed a simplified diagnostic strategy to reduce the use of computed tomography pulmonary angiography. OBJECTIVES: To externally validate this strategy in an independent cohort. METHODS: We analyzed data from three previous prospective cohort studies of outpatients with suspected PE. We retrospectively applied the YEARS algorithm. The three YEARS clinical criteria are: clinical signs of deep vein thrombosis, hemoptysis, and PE as the most likely diagnosis. If zero YEARS criteria are met, a D-dimer < 1000 ng/mL will rule out PE. If ≥1 YEARS criteria are met, a D-dimer < 500 ng/mL will rule out PE. RESULTS: Of the 3314 patients, 731 (22.1%) had PE. Applying the YEARS diagnostic algorithm, 1423 (42.9%) patients could have had PE ruled out without imaging. Of these patients, 17 (1.2%; 95% confidence interval 0.8-1.9) were diagnosed with PE at initial testing. All 17 had no YEARS item and a D-dimer < 1000 ng/mL. All 17 had a D-dimer level above their age-adjusted cutoff. Among the 272 patients with no YEARS criteria and a D-dimer < 1000 ng/mL but above their age-adjusted D-dimer cutoff, PE was diagnosed in 6.3% (17/272; 95% confidence interval 3.9-9.8). CONCLUSION: We provide external validation of the YEARS diagnostic algorithm in an independent cohort. The rule appears to safely exclude PE. However, caution is required in patients with no YEARS item and a D-dimer < 1000 ng/mL but above their age-adjusted D-dimer cutoff.

Published
2020

15. Hemorrhagic transformation in acute ischemic stroke patients and atrial fibrillation: time to initiation of anticoagulants and outcome

Author

Paciaroni, Maurizio, Bandini, Fabio, Agnelli, Giancarlo, Tsivgoulis, Georgios, Yaghi, Shadi, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monia, Volpi, Giacomo, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Targut, Marcheselli, Luca, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Guiseppe, Ntaios, George, Athanasakis, George, Makaritsis, Konstantinos, Karagkiozi, Efstathia, Vadikolias, Konstantinos, Liantinioti, Chirissoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Saxxo, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Colombo, Giovanna, Silvestrelli, Giorgio, Ciccone, Alfonso, Lanari, Alessia, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Ulivi, Leonardo, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, De Lodovici, Maria Luisa, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, D'Anna, Sebastiano, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Lotti, Enrico Maria, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Maimone Baronello, Mario, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Navveed, Gourbali, Vanessa, and Caso, Valeria

Abstract

Background: \ud In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents ischemic recurrence but with the risk of hemorrhagic transformation (HT). The aims of this study were to evaluate in consecutive patients with acute stroke and atrial fibrillation (1) the incidence of early HT, (2) the time to initiation of anticoagulation in patients with HT, (3) the association of HT with ischemic recurrences, and (4) the association of HT with clinical outcome at 90 days.\ud \ud Methods and Results: \ud HT was diagnosed by a second brain computed tomographic scan performed 24 to 72 hours after stroke onset. The incidence of ischemic recurrences as well as mortality or disability (modified Rankin Scale scores >2) were evaluated at 90 days. Ischemic recurrences were the composite of ischemic stroke, transient ischemic attack, or systemic embolism. Among the 2183 patients included in the study, 241 (11.0%) had HT. Patients with and without HT initiated anticoagulant therapy after a mean 23.3 and 11.6 days, respectively, from index stroke. At 90 days, 4.6% (95% confidence interval, 2.3–8.0) of the patients with HT had ischemic recurrences compared with 4.9% (95% confidence interval, 4.0–6.0) of those without HT; 53.1% of patients with HT were deceased or disabled compared with 35.8% of those without HT. On multivariable analysis, HT was associated with mortality or disability (odds ratio, 1.71; 95% confidence interval, 1.24–2.35).\ud \ud Conclusions: \ud In patients with HT, anticoagulation was initiated about 12 days later than patients without HT. This delay was not associated with increased detection of ischemic recurrence. HT was associated with increased mortality or disability.

Published
2018

16. Hemorrhagic Transformation in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Time to Initiation of Oral Anticoagulant Therapy and Outcomes

Author

Paciaroni, Maurizio, primary, Bandini, Fabio, additional, Agnelli, Giancarlo, additional, Tsivgoulis, Georgios, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Becattini, Cecilia, additional, Zedde, Marialuisa, additional, Abdul‐Rahim, Azmil H., additional, Lees, Kennedy R., additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D'Amore, Cataldo, additional, Mosconi, Maria Giulia, additional, Cimini, Ludovica Anna, additional, Altavilla, Riccardo, additional, Volpi, Giacomo, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Cappellari, Manuel, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Masotti, Luca, additional, Vannucchi, Vieri, additional, Sohn, Sung‐Il, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Ntaios, George, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, Karagkiozi, Efstathia, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrissoula, additional, Chondrogianni, Maria, additional, Mumoli, Nicola, additional, Consoli, Domenico, additional, Galati, Franco, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Lanari, Alessia, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Ulivi, Leonardo, additional, Orlandi, Giovanni, additional, Giannini, Nicola, additional, Gialdini, Gino, additional, Tassinari, Tiziana, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Rueckert, Christina, additional, Baldi, Antonio, additional, D'Anna, Sebastiano, additional, Toni, Danilo, additional, Letteri, Federica, additional, Giuntini, Martina, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Pieroni, Alessio, additional, Kargiotis, Odysseas, additional, Karapanayiotides, Theodore, additional, Monaco, Serena, additional, Maimone Baronello, Mario, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Michel, Patrik, additional, Vanacker, Peter, additional, Barlinn, Kristian, additional, Pallesen, Lars‐Peder, additional, Barlinn, Jessica, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Gourbali, Vanessa, additional, and Caso, Valeria, additional

Published
2018
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18. Early recurrence in paroxysmal versus sustained atrial fibrillation in patients with acute ischaemic stroke

Author

Paciaroni, Maurizio, primary, Angelini, Filippo, additional, Agnelli, Giancarlo, additional, Tsivgoulis, Georgios, additional, Furie, Karen L, additional, Tadi, Prasanna, additional, Becattini, Cecilia, additional, Falocci, Nicola, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil H, additional, Lees, Kennedy R, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, Altavilla, Riccardo, additional, D’Amore, Cataldo, additional, Mosconi, Maria G, additional, Cimini, Ludovica A, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Cappellari, Manuel, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Bandini, Fabio, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Masotti, Luca, additional, Vannucchi, Vieri, additional, Sohn, Sung-Il, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Ntaios, George, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Kostantinos, additional, Vadikolias, Kostantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Mumoli, Nicola, additional, Consoli, Domenico, additional, Galati, Franco, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Orlandi, Giovanni, additional, Giannini, Nicola, additional, Gialdini, Gino, additional, Tassinari, Tiziana, additional, Lodovici, Maria Luisa De, additional, Bono, Giorgio, additional, Rueckert, Christina, additional, Baldi, Antonio, additional, Toni, Danilo, additional, Letteri, Federica, additional, Giuntini, Martina, additional, Lotti, Enrico M, additional, Flomin, Yuriy, additional, Pieroni, Alessio, additional, Kargiotis, Odysseas, additional, Karapanayiotides, Theodore, additional, Monaco, Serena, additional, Baronello, Mario M, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Sette, Massimo Del, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Michel Pd-Mer, Patrik, additional, Vanacker, Peter, additional, Barlinn, Kristian, additional, Pallesen, Lars P, additional, Kepplinger, Jessica, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Gourbali, Vanessa, additional, Yaghi, Shadi, additional, and Caso, Valeria, additional

Published
2018
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20. Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non–Vitamin‐K Oral Anticoagulants (RAF‐NOACs) Study

Author

Paciaroni, Maurizio, primary, Agnelli, Giancarlo, additional, Falocci, Nicola, additional, Tsivgoulis, Georgios, additional, Vadikolias, Kostantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Cappellari, Manuel, additional, Zedde, Marialuisa, additional, Ntaios, George, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Kostantinos, additional, Silvestrelli, Giorgio, additional, Lanari, Alessia, additional, Ciccone, Alfonso, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Abdul‐Rahim, Azmil H., additional, Lees, Kennedy R., additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D'Amore, Cataldo, additional, Becattini, Cecilia, additional, Mosconi, Maria Giulia, additional, Cimini, Ludovica Anna, additional, Soloperto, Rossana, additional, Masotti, Luca, additional, Vannucchi, Vieri, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung‐Il, additional, Marcheselli, Simona, additional, Mumoli, Nicola, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Yaghi, Shadi, additional, Toni, Danilo, additional, Letteri, Federica, additional, Tassinari, Tiziana, additional, Kargiotis, Odysseas, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Giannini, Nicola, additional, Bandini, Fabio, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Consoli, Domenico, additional, Galati, Franco, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Gialdini, Gino, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Monaco, Serena, additional, Maimone Baronello, Mario, additional, Karapanayiotides, Theodore, additional, and Caso, Valeria, additional

Published
2017
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21. Early recurrence in paroxysmal versus sustained atrial fibrillation in patients with acute ischaemic stroke

Author

Paciaroni, Maurizio, Angelini, Filippo, Agnelli, Giancarlo, Tsivgoulis, Georgios, Furie, Karen L, Tadi, Prasanna, Becattini, Cecilia, Falocci, Nicola, Zedde, Marialuisa, Abdul-Rahim, Azmil H, Lees, Kennedy R, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, Altavilla, Riccardo, D’Amore, Cataldo, Mosconi, Maria G, Cimini, Ludovica A, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, Lodovici, Maria Luisa De, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Lotti, Enrico M, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Baronello, Mario M, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Sette, Massimo Del, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel Pd-Mer, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars P, Kepplinger, Jessica, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Gourbali, Vanessa, Yaghi, Shadi, and Caso, Valeria

Abstract

Background The relationship between different patterns of atrial fibrillation and early recurrence after an acute ischaemic stroke is unclear.Purpose In a prospective cohort study, we evaluated the rates of early ischaemic recurrence after an acute ischaemic stroke in patients with paroxysmal atrial fibrillation or sustained atrial fibrillation which included persistent and permanent atrial fibrillation.Methods In patients with acute ischaemic stroke, atrial fibrillation was categorised as paroxysmal atrial fibrillation or sustained atrial fibrillation. Ischaemic recurrences were the composite of ischaemic stroke, transient ischaemic attack and symptomatic systemic embolism occurring within 90 days from acute index stroke.Results A total of 2150 patients (1155 females, 53.7%) were enrolled: 930 (43.3%) had paroxysmal atrial fibrillation and 1220 (56.7%) sustained atrial fibrillation. During the 90-day follow-up, 111 ischaemic recurrences were observed in 107 patients: 31 in patients with paroxysmal atrial fibrillation (3.3%) and 76 with sustained atrial fibrillation (6.2%) (hazard ratio (HR) 1.86 (95% CI 1.24–2.81)). Patients with sustained atrial fibrillation were on average older, more likely to have diabetes mellitus, hypertension, history of stroke/ transient ischaemic attack, congestive heart failure, atrial enlargement, high baseline NIHSS-score and implanted pacemaker. After adjustment by Cox proportional hazard model, sustained atrial fibrillation was not associated with early ischaemic recurrences (adjusted HR 1.23 (95% CI 0.74–2.04)).Conclusions After acute ischaemic stroke, patients with sustained atrial fibrillation had a higher rate of early ischaemic recurrence than patients with paroxysmal atrial fibrillation. After adjustment for relevant risk factors, sustained atrial fibrillation was not associated with a significantly higher risk of recurrence, thus suggesting that the risk profile associated with atrial fibrillation, rather than its pattern, is determinant for recurrence.

Published
2019
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22. Poor predictive value of contemporary bleeding risk scores during long-term treatment of venous thromboembolism

Author

Bellesini, Marta, primary, Minno, Matteo Nicola Dario Di, primary, Mumoli, Nicola, primary, Pomero, Fulvio, primary, Franchini, Massimo, primary, Fantoni, Chiara, primary, Lupoli, Roberta, primary, Brondi, Barbara, primary, Borretta, Valentina, primary, Bonfanti, Carlo, primary, Ageno, Walter, primary, Dentali, Francesco, primary, and Riva, Nicoletta, additional

Published
2014
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24. Statin use and bleeding risk during vitamin K antagonist treatment for venous thromboembolism: a multicenter retrospective cohort study

Author

Massimo Franchini, Carlo Bonfanti, Nicoletta Riva, Nicola Mumoli, Matteo Nicola Dario Di Minno, Marta Bellesini, Roberta Lupoli, Silvia Sabatini, Francesco Dentali, Walter Ageno, Valentina Borretta, Fulvio Pomero, Riva, Nicoletta, DI MINNO, Matteo, Mumoli, Nicola, Pomero, Fulvio, Franchini, Massimo, Bellesini, Marta, Lupoli, Roberta, Sabatini, Silvia, Borretta, Valentina, Bonfanti, Carlo, Ageno, Walter, and Dentali, Francesco

Subjects
medicine.medical_specialty, Vitamin K, medicine.drug_class, Hemorrhage, Bleeding, Cohort study, Statins, Venous thromboembolism, Vitamin K antagonist, Blood Coagulation, Fibrinolytic Agents, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Retrospective Studies, Venous Thromboembolism, Hematology, Medicine (all), Gastroenterology, Cholesterol Synthesis Inhibition, Retrospective Studie, Internal medicine, Antithrombotic, Medicine, cardiovascular diseases, Online Only Articles, Fibrinolytic Agent, business.industry, Statin, Retrospective cohort study, Statin treatment, Surgery, lipids (amino acids, peptides, and proteins), Hydroxymethylglutaryl-CoA Reductase Inhibitor, business, Human
Abstract

Statins have several pleiotropic effects, beyond cholesterol synthesis inhibition, including anti-inflammatory and antithrombotic properties.[1][1] They have been shown to reduce the rate of venous thromboembolism (VTE), but whether this beneficial effect is counterbalanced by an increased

Published
2015

25. Poor predictive value of contemporary bleeding risk scores during long-term treatment of venous thromboembolism: A multicentre retrospective cohort study

Author

Marta Bellesini, Francesco Dentali, Carlo Bonfanti, Chiara Fantoni, Nicoletta Riva, Massimo Franchini, Barbara Brondi, Nicola Mumoli, Walter Ageno, Roberta Lupoli, Fulvio Pomero, Valentina Borretta, M. N. D. Di Minno, Riva, Nicoletta, Bellesini, Marta, DI MINNO, Matteo, Mumoli, Nicola, Pomero, Fulvio, Franchini, Massimo, Fantoni, Chiara, Lupoli, Roberta, Brondi, Barbara, Borretta, Valentina, Bonfanti, Carlo, Ageno, Walter, and Dentali, Francesco

Subjects
Male, Time Factors, Vitamin K, Predictive Value of Test, 030204 cardiovascular system & hematology, Cohort Studies, 0302 clinical medicine, Retrospective Studie, Medicine, 030212 general & internal medicine, Skin Test, Incidence (epidemiology), Medicine (all), Area under the curve, Venous Thromboembolism, Hematology, Vitamin K antagonist, Middle Aged, Predictive value, Italy, Research Design, Bleeding risk scores, Female, Human, medicine.medical_specialty, Time Factor, medicine.drug_class, Bleeding risk score, Hemorrhage, Follow-Up Studie, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, Humans, Long-term follow-up, Aged, Retrospective Studies, Skin Tests, business.industry, Anticoagulant, Anticoagulants, Retrospective cohort study, Confidence interval, Surgery, Venous thromboembolism, Follow-Up Studies, Cohort Studie, business, Complication
Abstract

SummaryBleeding is a common and feared complication of oral anticoagulant therapy. Several prediction models have been recently developed, but there is a lack of evidence in patients with venous thromboembolism (VTE). The aim of this study was to validate currently available bleeding risk scores during long-term oral anticoagulation for VTE. We retrospectively included adult patients on vitamin K antagonists for VTE secondary prevention, followed by five Italian Anticoagulation Clinics (Cuneo, Livorno, Mantova, Napoli, Varese), between January 2010 and August 2012. All bleeding events were classified as major bleeding (MB) or clinically-relevant-non-major-bleeding (CRNMB). A total of 681 patients were included (median age 63 years; 52.0% female). During a mean follow-up of 8.82 (± 3.59) months, 50 bleeding events occurred (13 MB and 37 CRNMB), for an overall bleeding incidence of 9.99/100 patient-years. The rate of bleeding was higher in the first three months of treatment (15.86/100 patient-years) than afterwards (7.13/100 patient-years). The HAS-BLED showed the best predictive value for bleeding complications during the first three months of treatment (area under the curve [AUC] 0.68, 95% confidence interval [CI] 0.59–0.78), while only the ACCP score showed a modest predictive value after the initial three months (AUC 0.61, 95%CI 0.51–0.72). These two scores had also the highest sensitivity and the highest negative predictive value. None of the scores predicted MB better than chance. Currently available bleeding risk scores had only a modest predictive value for patients with VTE. Future studies should aim at the creation of a new prediction rule, in order to better define the risk of bleeding of VTE patients.

Published
2014

26. Timing of initiation of oral anticoagulants in patients with acute ischemic stroke and atrial fibrillation comparing posterior and anterior circulation strokes.

Author

Paciaroni M, Agnelli G, Giustozzi M, Tsivgoulis G, Yaghi S, Grory BM, Furie KL, Tadi P, Zedde M, Abdul-Rahim AH, Dawson J, Lees KR, Alberti A, Venti M, Acciarresi M, D'Amore C, Mosconi MG, Bogini V, Cappellari M, Rigatelli A, Bonetti B, Putaala J, Tomppo L, Tatlisumak T, Bandini F, Marcheselli S, Pezzini A, Poli L, Padovani A, Masotti L, Grifoni E, Vannucchi V, Sohn SI, Lorenzini G, Tassi R, Guideri F, Acampa M, Martini G, Ntaios G, Athanasakis G, Makaritsis K, Karagkiozi E, Vadikolias K, Liantinioti C, Palaiodimou L, Mumoli N, Porta C, Galati F, Sacco S, Tiseo C, Corea F, Ageno W, Bellesini M, Silvestrelli G, Ciccone A, Scoditti U, Denti L, Mancuso M, Caselli MC, Maccarrone M, Ulivi L, Orlandi G, Giannini N, Tassinari T, Lodovici ML, Rueckert C, Baldi A, Toni D, Gentile L, Letteri F, Giuntini M, Lotti EM, Flomin Y, Pieroni A, Kargiotis O, Karapanayiotides T, Monaco S, Mannino M, Baronello MM, Csiba L, Szabó L, Chiti A, Giorli E, Sette MD, Schirinzi E, Imberti D, Zabzuni D, Doronin B, Volodina V, Michel P, Eskandari A, Vanacker P, Barlinn K, Barlinn J, Deleu D, Gourbali V, and Caso V

Abstract

Introduction: The aim of this study in patients with acute posterior ischaemic stroke (PS) and atrial fibrillation (AF) was to evaluate (1) the risks of recurrent ischaemic event and severe bleeding and (2) these risks in relation with oral anticoagulant therapy (OAT) and its timing., Materials and Methods: Patients with PS were prospectively included; the outcome events of these patients were compared with those of patients with anterior stroke (AS) which were taken from previous registries. The primary outcome was the composite of stroke recurrence, transient ischaemic attack, symptomatic systemic embolism, symptomatic cerebral bleeding and major extracranial bleeding occurring within 90 days from acute stroke., Results: A total of 2470 patients were available for the analysis: 473 (19.1%) with PS and 1997 (80.9%) with AS. Over 90 days, 213 (8.6%) primary outcome events were recorded: 175 (8.7%) in patients with AS and 38 (8.0%) in those with PS. In patients who initiated OAT within 2 days, the primary outcome occurred in 5 out of 95 patients (5.3%) with PS compared to 21 out of 373 patients (4.3%) with AS (OR 1.07; 95% CI 0.39-2.94). In patients who initiated OAT between days 3 and 7, the primary outcome occurred in 3 out of 103 patients (2.9%) with PS compared to 26 out of 490 patients (5.3%) with AS (OR 0.54; 95% CI 0.16-1.80)., Discussion: our findings suggest that, when deciding the time to initiate oral anticoagulation, the location of stroke, either anterior or posterior, does not predict the risk of outcome events., Conclusions: Patients with PS or AS and AF appear to have similar risks of ischaemic or haemorrhagic events at 90 days with no difference concerning the timing of initiation of OAT., (© European Stroke Organisation 2020.)

Published
2020
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27. Statin use and bleeding risk during vitamin K antagonist treatment for venous thromboembolism: a multicenter retrospective cohort study.

Author

Riva N, Di Minno MN, Mumoli N, Pomero F, Franchini M, Bellesini M, Lupoli R, Sabatini S, Borretta V, Bonfanti C, Ageno W, and Dentali F

Subjects
Blood Coagulation drug effects, Fibrinolytic Agents adverse effects, Hemorrhage mortality, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Retrospective Studies, Venous Thromboembolism blood, Venous Thromboembolism mortality, Fibrinolytic Agents therapeutic use, Hemorrhage etiology, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Venous Thromboembolism complications, Venous Thromboembolism drug therapy, Vitamin K antagonists & inhibitors
Published
2015
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