Search

Although the practice of forgiveness is encouraged, the healing properties of this virtue by health care professionals are often overlooked. Forgiveness is the voluntary, conscious decision to abandon negative feelings toward another who has caused hurt and replacing those feelings with unconditional love and compassion. It is not about forgetting the hurt or ignoring the pain; it is an actual transformation of the heart. The Enright Forgiveness Process Model and the Pyramid Model of Forgiveness are 2 models that facilitate the forgiveness process. By utilizing either of these pathways, the forgiver ultimately experiences peace of mind and a "release from emotional prison" that leads to holistic healing. As a result, the forgiver experiences lower levels of depression, anxiety, and aggression, which improves quality of life. In addition, physiological benefits such as decreased stress levels, lower blood pressure, and a lower heart rate have also been reported. Throughout the course of their careers, nurses encounter patients and families in acute or end-of-life care situations who want to forgive or be forgiven. As holistic health care providers, nurses should be able to facilitate and close this gap in patient care. This article attempts to raise awareness to the importance of forgiveness in health and well-being among nurses and other health care professionals.

Purpose of study: The need for forgiveness education for nursing self-care and forgiveness facilitation has risen. Therefore, the present pilot study tested the efficacy of an 8-week forgiveness bibliotherapy with a small number of undergraduate nursing students. Design of study: Matched pairs of nursing students were randomly assigned to either the experimental group or no-contact control group. The experimental group, using 8 keys to forgiveness by R. Enright (2015) as the treatment manual, read one chapter a week for 8 weeks and provided weekly reflections. Forgiveness and forgiveness-related outcome measures were administered at pretest, posttest, and one-month follow-up. Findings: At the posttest, the experimental group had significantly greater improvement in forgiveness compared to the control group with a large effect size, which was maintained at one month follow-up. There was no other significant difference between the two groups. Within-group comparisons of the experimental group showed improvement in forgiveness, anxiety, depression, and fatigue from pre to post testing periods and forgiveness, anger, anxiety, depression, and fatigue from pre to follow-up testing periods. Conclusion: Use of bibliotherapy may be a cost-effective way to promote the virtue of forgiveness for students in nursing programs.

Scale structure and reflectance activity of a Mindanao endemic weevil from the genus Metapocyrtus has been studied for the first time. Specimens of Metapocyrtus apoensis Schultze, 1925 were collected through opportunistic sampling in Mount Calayo, Musuan, Mindanao, Philippines last February 2020. A total of three individuals of the species were collected all in lower dipterocarp forest with elevation of 500 masl–600 masl. Three specimens were then examined under Scanning Electron Microscopy with Energy Dispersive X-Ray (SEM_EDX) to analyse its scale structures and reflectance activity. The study provides new locality record of the Mindanao endemic species first in Bukidnon region and an updated distribution in Mindanao based on recent published articles and museum collections. The species inhabits wide ranges of habitat types that greatly differ in elevation and vegetation. Examination of scale’s structure through SEM revealed that M. apoensis scales are 50 μm–70 μm in diameter which are almost circular in shape, slightly convex with rough like surface which is termed as non-ordered nipple-like structure. The scales’ shape and surface structure clearly differ from other genera of curculionids based on published articles. Analysis of the particles on the weevil’s elytra done by EDX reveals several elements that contribute to its iridescence. Major elements such as carbon (42.3%), oxygen (27.7%) and nitrogen (15.1%) come in relatively high atomic concentrations. Microspectrometer revealed a peak reflectance wavelength of about 569.7 nm. This explains the yellow-green iridescence observed on the dorsal side of the weevil. The concentration of the scale in pits serves for protection, intraspecific recognition and camouflage. Despite of widespread distribution and high abundance of this species in Mindanao, anthropogenic disturbances such as agricultural activities are on-going which extend towards their microhabitat. Monitoring to its population is recommended as the species is restricted only in Mindanao.

Nuclear power plants (NPPs) require accurate measurement of mass flow rates. Advanced flowmeters have been widely applied in several current industries; however, the operating environment in NPPs i...

Ten-eleven translocation (TET) enzymes are epigenetic enzymes that are responsible for the iterative oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine (5caC) on genomic DNA using a catalytic 2-oxoglutarate (2OG) dependent oxygenase domain. These epigenetic marks are associated with transcriptional activation and silencing depending on the modification and context. Furthermore, 5fC and 5caC participate in active demethylation pathways to revert back to cytosine (C) creating a dynamic cycle. TET enzymes play an essential role in shaping the epigenome and loss of TET2’s function has frequently been described in haematopoietic malignancies with notable examples being myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). To investigate the functional role of TET enzymes in a cellular context in greater detail, chemical probes can aid in understanding the effect of TET inhibition and can elicit a biological response. Here, two robust orthogonal high-throughput screening technologies were developed for kinetic analysis of TET enzymes and inhibitor profiling. Examination of a focused small-molecule library revealed differences in potency amongst TET isoforms and 2OG-dependent oxygenases. These results provide the initial scaffolds as a starting point for further inhibitor development. A myriad of epigenetic modifications is found on histones in nucleosome complexes. A common post translational modification is Nε-lysine methylation which is linked to transcriptional silencing or activation depending on the location within the nucleosome. The methylation levels are under dynamic control of histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs) while readout is performed by chromatin binding modules. In order to study the biological role of lysine methylation and participation in orchestrating the epigenetic landscape, chemical probes can be used. However, the relative high number of structurally related proteins and corresponding domains found in humans consisting of KMTs (SET: ~25), KDMs (JumonjiC domain: ~25) and chromatin binding modules (tudor domain (TD): ~25; plant homeodomain (PHD): >100) makes it challenging to produce both potent and specific inhibitors. The development of inhibitors for Nε-trimethyllysine chromatin binding modules to date, have been plagued with relatively weak inhibition but also with off-target effects. To aid in the development of inhibitors, epigenetic tools were developed, and their effectiveness was explored against a panel of chromatin binding modules. The tools were then applied in probing the PHD of multiple KDMs including KDM5s (JARID1s) and KDM7B (PHF8). The collective results show that these new tools can be utilized for the development of potent and selective inhibitors of chromatin binding modules that may in the future be used for targeted therapies.