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3. Il fratello

Author

Donegani, S., Bellardita, L., Bellardita, Lara, editor, Magnani, Tiziana, editor, and Valdagni, Riccardo, editor

Published
2013
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10. Digitalizzazione, Ricerca clinica e Medicina, tra cambi di paradigma, 'comodità e socialità' [Digitalization, clinical research and medicine, between paradigm shifts, user-friendliness and social relations]

Author

Borgonovi, E., Bellardita, L., Capolongo, S., Collicelli, C., Da Ros, L., Durst, L., Gussoni, G., Mannelli, C., Petrini, C., Recchia, G., Trogu, P., and Zagarrì, E.

Subjects
user-friendliness, medicine, clinical research, Ricerca clinica, Medicina, Digitalizzazione, social aspect, Edilizia sanitaria, Digitalizzazione, Ricerca clinica, Medicina, social aspect, healthcare design, Digitalization, social relations, Edilizia sanitaria, healthcare design, Digitalization, clinical research, medicine, user-friendliness, social relations
Published
2022

13. Prostate cancer awareness among Italian adult males: a national web-based survey

Author

Sighinolfi, M.C., primary, Battaglia, M., additional, Bellardita, L., additional, Castiglioni, S., additional, Dal Moro, F., additional, De Giorgi, U., additional, De Monte, A., additional, Di Maio, M., additional, Gaboardi, F., additional, Gontero, P., additional, Jereczek, B.A., additional, Leonardi, R., additional, Lombardi, E., additional, Madonia, M., additional, Mangiagalli, A., additional, Marenghi, C., additional, Marrocco, W., additional, Masini, C., additional, Miano, R., additional, Polloni, G., additional, Prezioso, D., additional, Ruffini, L., additional, Sabbatini, R., additional, Schips, L., additional, Selli, C., additional, Valdagni, R., additional, Varca, V., additional, Veneziano, P., additional, Calcagnile, T., additional, and Rocco, B., additional

Published
2021
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15. A predictive model to personalize follow up schedules for patients in active surveillance

Author

Badenchini, F., primary, Marenghi, C., additional, Avuzzi, B., additional, Bellardita, L., additional, Casale, A., additional, Catanzaro, M., additional, Claps, M., additional, Colecchia, M., additional, De Luca, L., additional, Di Florio, T., additional, Donegani, S., additional, Dordoni, P., additional, Macchi, A., additional, Messina, A., additional, Morlino, S., additional, Noris Chiorda, B., additional, Stagni, S., additional, Tesone, A., additional, Torelli, T., additional, Villa, S., additional, Zollo, F., additional, Magnani, T., additional, Rancati, T., additional, Valdagni, R., additional, and Nicolai, N., additional

Published
2020
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16. Favourable and reliable PSA doubling time can improve confidence in reducing the number of repeat biopsy during active surveillance

Author

Badenchini, F., primary, Marenghi, C., additional, Avuzzi, B., additional, Bellardita, L., additional, Casale, A., additional, Catanzaro, M., additional, Claps, M., additional, Colecchia, M., additional, De Luca, L., additional, Di Florio, T., additional, Donegani, S., additional, Dordoni, P., additional, Macchi, A., additional, Messina, A., additional, Morlino, S., additional, Noris Chiorda, B., additional, Stagni, S., additional, Tesone, A., additional, Torelli, T., additional, Villa, S., additional, Zollo, F., additional, Magnani, T., additional, Rancati, T., additional, Valdagni, R., additional, and Nicolai, N., additional

Published
2019
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18. SC98 - Prostate cancer awareness among Italian adult males: a national web-based survey

Author

Sighinolfi, M.C., Battaglia, M., Bellardita, L., Castiglioni, S., Dal Moro, F., De Giorgi, U., De Monte, A., Di Maio, M., Gaboardi, F., Gontero, P., Jereczek, B.A., Leonardi, R., Lombardi, E., Madonia, M., Mangiagalli, A., Marenghi, C., Marrocco, W., Masini, C., Miano, R., Polloni, G., Prezioso, D., Ruffini, L., Sabbatini, R., Schips, L., Selli, C., Valdagni, R., Varca, V., Veneziano, P., Calcagnile, T., and Rocco, B.

Published
2021
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19. Italian cultural adaptation of the Memorial Anxiety for Prostate Cancer scale for the population of men on active surveillance

Author

Alvisi, M. F., Repetto, Claudia, Rancati, T., Badenchini, F., Magnani, T., Marenghi, C., Villa, S., Nicolai, N., Salvioni, R., Avuzzi, B., Valdagni, R., Bellardita, Lara, Repetto C. (ORCID:0000-0001-8365-7697), Bellardita L., Alvisi, M. F., Repetto, Claudia, Rancati, T., Badenchini, F., Magnani, T., Marenghi, C., Villa, S., Nicolai, N., Salvioni, R., Avuzzi, B., Valdagni, R., Bellardita, Lara, Repetto C. (ORCID:0000-0001-8365-7697), and Bellardita L.

Abstract

PURPOSE: The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) is a self-report questionnaire that was developed in English to assess prostate cancer (PCa)-related anxiety. The aim of this study was to perform a cultural adaptation for the tool to be used in a population of Italian men on active surveillance (AS).METHODS: A total of 222 patients with localized PCa who were recruited for the Prostate Cancer Research International: Active Surveillance (PRIAS) protocol completed the MAX-PC. Psychometric analysis was performed to assess reliability indexes. A Spearman rank correlation was used to test the association between MAX-PC scales and other questionnaires and was used for longitudinal analysis.RESULTS: Cronbach coefficients and item to total correlation demonstrated good internal consistency. Some items related to the repetition of the PSA test showed a large floor effect and thus were poorly effective in measuring anxiety for PSA testing in patients on AS. Confirmatory factor analysis partly failed to reproduce the structure of the original version. A modified version of MAX-PC, excluding the items with a large floor effect, was thus considered for AS patients. Factor analysis on this version demonstrated considerable consistency with the presence of 3 subscales: anxiety related to PCa, anxiety related to PSA testing, and anxiety related to the fear of tumor progression. Longitudinal analysis showed an acceptable validity over time. The MAX-PC was correlated with the anxious preoccupation subscale of the Mini-Mental Adjustment to Cancer scale.CONCLUSIONS: A slightly modified version of the MAX-PC was developed for use in Italian men on AS. This instrument appears to be a valid and reliable tool that measures anxiety in men with PCa who are enrolled in AS programs.

Published
2018

21. Compliance of prostate cancer patients on active surveillance to protocol criteria: The experience of a large mono-institutional population

Author

Badenchini, F., primary, Palorini, F., additional, Alvisi, M.F., additional, Marenghi, C., additional, Tulli Baldoin, E., additional, Nicolai, N., additional, Salvioni, R., additional, Catanzaro, M., additional, Stagni, S., additional, Tesone, A., additional, Torelli, T., additional, Villa, S., additional, Bedini, N., additional, Avuzzi, B., additional, Morlino, S., additional, Colecchia, M., additional, Messina, A., additional, Bellardita, L., additional, Magnani, T., additional, Rancati, T., additional, and Valdagni, R., additional

Published
2017
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22. Setting an Agenda for Assessment of Health-related Quality of Life Among Men with Prostate Cancer on Active Surveillance: A Consensus Paper from a European School of Oncology Task Force

Author

Villa, S. (Silvia), Kendel, F. (Friederike), Venderbos, L.D.F. (Lionne), Rancati, T. (Tiziana), Bangma, C.H. (Chris), Carroll, P.R. (Peter), Denis, L.J. (Louis), Klotz, L. (Laurence), Korfage, I.J. (Ida), Lane, J.A. (Janet), Magnani, T. (Tiziana), Mastris, K. (Ken), Rannikko, A.S. (Antti), Roobol-Bouts, M.J. (Monique), Trock, B.J. (Bruce), Bergh, R.C.N. (Roderick) van den, Poppel, H. (Hein) van, Valdagni, R. (Riccardo), Bellardita, L. (Lara), Villa, S. (Silvia), Kendel, F. (Friederike), Venderbos, L.D.F. (Lionne), Rancati, T. (Tiziana), Bangma, C.H. (Chris), Carroll, P.R. (Peter), Denis, L.J. (Louis), Klotz, L. (Laurence), Korfage, I.J. (Ida), Lane, J.A. (Janet), Magnani, T. (Tiziana), Mastris, K. (Ken), Rannikko, A.S. (Antti), Roobol-Bouts, M.J. (Monique), Trock, B.J. (Bruce), Bergh, R.C.N. (Roderick) van den, Poppel, H. (Hein) van, Valdagni, R. (Riccardo), and Bellardita, L. (Lara)

Abstract

Background: Literature on the health-related quality of life (HRQoL) for men with localized prostate cancer (PCa) on active surveillance (AS) shows a need for methodological guidance regarding HRQoL issues and how to address them. Objective: The European School of Oncology Task Force (ESO TF) aimed to identify a core set of research questions and related measures to include in AS HRQoL studies. Design, setting, and participants: A modified Delphi study was used to reach consensus on AS HRQoL research topics and tools between 2014 and 2015. Data were collected by engaging a multidisciplinary team of 15 experts. Outcome measurements and statistical analysis: An open-ended questionnaire was used to collect information from ESO TF members regarding issues in AS HRQoL research. Then a structured questionnaire was used to collect ratings on the usefulness/importance of different AS HRQoL aspects. Items that ≥80% of ESO TF members rated as useful/important were retained. Items with a 50-80% rating were discussed to reach final agreement. Results and limitations: Six main research questions concerning the selection of outcome measures, measurement tools, and comparison groups were identified as relevant. The core set of measures identified were related to individual characteristics, psychological dimensions; decision-making-related issues, and physical functioning. The multidisciplinary expertise of ESO TF members was a significant asset, even if bringing different backgrounds to the discussion table represented a challenge. Conclusions: HRQoL measures have to be sensitive to the specific needs of men on AS. The definition of HRQoL outcomes will enhance a broader understanding of the HRQoL of men on AS and sustain patient-centered medicine. Patient summary: An international panel agreed on a set of health-related quality-of-life aspects to be assessed among men on active surveillance for prostate cancer. Valid relevant questionnaires were identified. The experts' indication

Published
2017
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23. P081 - Favourable and reliable PSA doubling time can improve confidence in reducing the number of repeat biopsy during active surveillance

Author

Badenchini, F., Marenghi, C., Avuzzi, B., Bellardita, L., Casale, A., Catanzaro, M., Claps, M., Colecchia, M., De Luca, L., Di Florio, T., Donegani, S., Dordoni, P., Macchi, A., Messina, A., Morlino, S., Noris Chiorda, B., Stagni, S., Tesone, A., Torelli, T., Villa, S., Zollo, F., Magnani, T., Rancati, T., Valdagni, R., and Nicolai, N.

Published
2019
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26. A validation analysis confirming different predictors of upgrading and upsizing at 1-year repeat biopsy in low-risk prostate cancer patients on active surveillance

Author

Nicolai, N., primary, Alvisi, M., additional, Badenchini, F., additional, Marenghi, C., additional, Tulli, Baldoin E., additional, Villa, S., additional, Bedini, N., additional, Avuzzi, B., additional, Bosetti, D., additional, Morlino, S., additional, Salvioni, R., additional, Stagni, S., additional, Torelli, T., additional, Biasoni, D., additional, Catanzaro, M., additional, Colecchia, M., additional, Paolini, B., additional, Bellardita, L., additional, Magnani, T., additional, Rancati, T., additional, and Valdagni, R., additional

Published
2016
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27. How does active surveillance for prostate cancer affect quality of life? A systematic review

Author

Bellardita, L, Valdagni, R, Van Den Bergh, R, Randsdorp, H, Repetto, Claudia, Venderbos, Ldf, Lane, Ja, Korfage, Ij, Repetto, Claudia (ORCID:0000-0001-8365-7697), Bellardita, L, Valdagni, R, Van Den Bergh, R, Randsdorp, H, Repetto, Claudia, Venderbos, Ldf, Lane, Ja, Korfage, Ij, and Repetto, Claudia (ORCID:0000-0001-8365-7697)

Abstract

The optimal management of screen-detected, localised prostate cancer remains controversial, related to overtreatment issues of screening and the nonrandomised evidence base. Active surveillance (AS) aims to delay or avoid curative therapy but may potentially harm patients' well-being through living with untreated prostate cancer.

Published
2015

28. 824 PRIAS vs SAINT: Comparing two active surveillance protocols

Author

Alvisi, M.F., primary, Rancati, T., additional, Badenchini, F., additional, Marenghi, C., additional, Colecchia, M., additional, Paolini, B., additional, Salvioni, R., additional, Villa, S., additional, Maffezzini, M., additional, Stagni, S., additional, Catanzaro, M., additional, Torelli, T., additional, Nicolai, N., additional, Biasoni, D., additional, Avuzzi, B., additional, Bedini, N., additional, Morlino, S., additional, Tulli Baldoin, E., additional, Bellardita, L., additional, Magnani, T., additional, and Valdagni, R., additional

Published
2015
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29. PO-0730: Urinary and erectile function in prostate cancer patients: radical radiotherapy vs active surveillance

Author

Alvisi, M.F., primary, Rancati, T., additional, Badenchini, F., additional, Fiorino, C., additional, Cozzarini, C., additional, Palorini, F., additional, Vavassori, V., additional, Girelli, G., additional, Degli Esposti, C., additional, Morlino, S., additional, Avuzzi, B., additional, Marenghi, C., additional, Villa, S., additional, Bellardita, L., additional, Catanzaro, M., additional, Salvioni, R., additional, and Valdagni, R., additional

Published
2015
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30. Clinical and psychological telemonitoring and telecare of high risk heart failure patients

Author

Villani, A, Malfatto, G, Compare, A, DELLA ROSA, F, Bellardita, L, Branzi, G, Molinari, E, Parati, G, DELLA ROSA, FRANCESCO, PARATI, GIANFRANCO, Villani, A, Malfatto, G, Compare, A, DELLA ROSA, F, Bellardita, L, Branzi, G, Molinari, E, Parati, G, DELLA ROSA, FRANCESCO, and PARATI, GIANFRANCO

Abstract

We conducted a trial of telemonitoring and telecare for patients with chronic heart failure leaving hospital after being treated for clinical instability. Eighty patients were randomized before hospital discharge to a usual care group (n = 40: follow-up at the outpatient clinic) or to an integrated management group (n = 40: patients learned to use a handheld PDA and kept in touch daily with the monitoring centre). At enrolment, the groups were similar for all clinical variables. At one-year follow-up, integrated management patients showed better adherence, reduced anxiety and depression, and lower NYHA class and plasma levels of BNP with respect to the usual care patients (e.g. NYHA class 2.1 vs 2.4, P < 0.02). Mortality and hospital re-admissions for congestive heart failure were also reduced in integrated management patients (P < 0.05). Integrated management was more expensive than usual care, although the cost of adverse events was 42% lower. In heart failure patients at high risk of relapse, the regular acquisition of simple clinical information and the possibility for the patient to contact the clinical staff improved drug titration, produced better psychological status and quality of life, and reduced hospitalizations for heart failure.

Published
2014

33. Patient's choice of observational strategy for early-stage prostate cancer

Author

Bellardita, L., Graffigna, Guendalina, Donegani, S, Villani, Daniela, Villa, S., Tresoldi, V., Marenghi, C., Magnani, T., Valdagni, R., Graffigna, Guendalina (ORCID:0000-0003-4378-7467), Villani, Daniela (ORCID:0000-0002-2435-4036), Bellardita, L., Graffigna, Guendalina, Donegani, S, Villani, Daniela, Villa, S., Tresoldi, V., Marenghi, C., Magnani, T., Valdagni, R., Graffigna, Guendalina (ORCID:0000-0003-4378-7467), and Villani, Daniela (ORCID:0000-0002-2435-4036)

Abstract

Active Surveillance (AS) may represent for selected patients with low risk, potentially indolent prostate cancer (PCa) a viable alternative to radical therapies, thus reducing the risk of over-treatment.Researchers and clinicians emphasized that the choice of AS may be acontroversial one as patients have the chance to avoid the side effects of radical therapies but also the burden of living with an untreated PCa. The aim of our study is to focus on the decision-making process leading patients to elect AS amongst different therapeutic options.An observational, qualitative study was conducted. Between 2007 and 2009, 46 patients (mean age 67 years) were administered a semi-structured interview at enrolment in the Prostate Cancer Research International: Active Surveillance protocol. The focus of the interview was onthe first question, i.e. "Why did you choose AS?". Interviews were audio-recorded and verbatim transcriptions were made. Content analyses were performed by using a text-driven, automatic software (T-lab). Four clusters of themes emerged. In cluster 1, the most meaningful theme was the ambivalence in front of different therapeutic options. In cluster 2, the focus was on patients' assessment of the aggressivenessof their PCa. In cluster 3, the topic was the collection of information from specialists. In cluster 4, the main theme was the collection of data through informal sources. Patients are motivated to opt for AS based on the subjective evaluation of medical information as well as characteristics of their psycho-social context. Understanding motivation for AS will help clinicians support patients in making the bestchoice for them.

Published
2012

34. P028 - A validation analysis confirming different predictors of upgrading and upsizing at 1-year repeat biopsy in low-risk prostate cancer patients on active surveillance

Author

Nicolai, N., Alvisi, M., Badenchini, F., Marenghi, C., Tulli, Baldoin E., Villa, S., Bedini, N., Avuzzi, B., Bosetti, D., Morlino, S., Salvioni, R., Stagni, S., Torelli, T., Biasoni, D., Catanzaro, M., Colecchia, M., Paolini, B., Bellardita, L., Magnani, T., Rancati, T., and Valdagni, R.

Published
2016
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36. P065 Active Surveillance in prostate cancer: 8 years' experience

Author

Marenghi, C., primary, Rancati, T., additional, Magnani, T., additional, Biasoni, D., additional, Nicolai, N., additional, Stagni, S., additional, Avuzzi, B., additional, Bedini, N., additional, Morlino, S., additional, Villa, S., additional, Alvisi, M.F., additional, Bellardita, L., additional, Salvioni, R., additional, and Valdagni, R., additional

Published
2013
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37. P063 Different predictors of upgrading and upsizing at 1-year repeat biopsy in men with low-risk prostate cancer undergoing active surveillance in prospective trials

Author

Nicolai, N., primary, Alvisi, M.F., additional, Rancati, T., additional, Salvioni, R., additional, Stagni, S., additional, Marenghi, C., additional, Magnani, T., additional, Bellardita, L., additional, Colecchia, M., additional, Morlino, S., additional, Avuzzi, B., additional, Zaffaroni, N., additional, and Valdagni, R., additional

Published
2013
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41. Adaptation and validation of an Italian version of the Prostate Cancer Specific Quality of Life Instrument (PROSQOLI).

Author

BELLARDITA, L., DAMIANO, R., PORPIGLIA, F., SCATTONI, V., AMODEO, A., BORTOLUS, R., LAPINI, A., COCCI, A., CICALESE, V., CAPONERA, M., MASTRANGELO, P., FRANCESCA, F., VALDAGNI, R., TAVERNA, G., DI TRAPANI, D., LEONARDI, R., MINOCCI, D., GABOARDI, F., MONTANARI, E., and CONTI, G.

Abstract

OBJECTIVE: The Prostate Cancer Specific Quality of Life Instrument (PROSQOLI) is a measure of health-related quality of life (HRQoL) in advanced hormone-resistant prostate cancer. In this study, we aimed at performing a cross-cultural adaptation and validation of the Italian version of the PROSQOLI. PATIENTS AND METHODS: The original version of the PROSQOLI underwent several turnarounds of translations. A total of 472 patients treated with radical prostatectomy, radiotherapy or medical therapy were enrolled for the validation of the questionnaire. The PROSQOLI was administered together with the SF-12. Reliability indexes were calculated by using Cronbach alpha. To evaluate the validity of the construct, relationships between PROSQOLI and SF12 were assessed. The ANOVA test was used to evaluate the differences between groups of patients who had received different treatments. RESULTS: The reliability coefficient was 0.91. Item-to-total correlation indices were in most cases >0.70. The correlation between the scores of the PROSQOLI and those of the SF-12 questionnaire was high (r=0.8139, p<0.0001). The ANOVA test showed significant differences between groups (p<0.01) based on age, recurrence risk and treatment. CONCLUSIONS: The adaptation process showed that the PROSQOLI Italian version has high reliability and presents both convergent and discriminant validity. This version of the tool can be used to assess HRQoL in Italian men who underwent radical treatment for advanced prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2016

42. P068 Active surveillance in prostate cancer: 7 year experience

Author

Marenghi, C., primary, Nicolai, N., additional, Rancati, T., additional, Alvisi, M.F., additional, Bellardita, L., additional, Avuzzi, B., additional, Stagni, S., additional, Villa, S., additional, Magnani, T., additional, Bedini, N., additional, Salvioni, R., additional, and Valdagni, R., additional

Published
2012
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50. 1012 PATIENTS CHOOSING ACTIVE SURVEILLANCE: HEALTH- RELATED QUALITY OF LIFE AND ADJUSTMENT TO DISEASE AT THE ENTRANCE IN THE PROTOCOL

Author

Bellardita, L., primary, Donegani, S., additional, Villani, D., additional, Magnani, T., additional, Salvioni, R., additional, Nicolai, N., additional, Biasoni, D., additional, Torelli, T., additional, Stagni, S., additional, Catanzaro, M., additional, Villa, S., additional, Bedini, N., additional, Avuzzi, B., additional, and Rancati, T., additional

Published
2011
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