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BACKGROUND: The regional dimension of public health is one characteristic of public health that reflects the effectiveness of social and economic change in society. The key components of which are health and demographic indicators. The regions current demographic situation is an essential component of comprehensive medical and social research. Health and demographic indicators describe the dynamics, state, and prospects of social and economic changes in health and society as a whole. The increase in the population and labor resources due to migration growth, the increase in mortality rates, the decline in the birth rate, and the aging of the nation presupposes the development and implementation of additional medico-demographic approaches to the strategic development of the region. AIMS: Аnalysis of key indicators of public health of Krasnodar Krai, including the main medico-demographic indicators in the dynamics for 20182020. MATERIALS AND METHODS: A retrospective analysis on some aspects of the regions public health for 20182020 was conducted. Included in the development are medico-demographic indicators of the population, fertility, mortality, natural increase (losses), and so forth, in the dynamics for 20182020. Data from the Federal Service of State Statistics and statistical data of reporting forms of medical organizations of Krasnodar Krai Information about medical organization (p. 30) were used in the study for the period under consideration. The study applied statistical, analytical, and descriptive methods. The statistical processing of the material was carried out with the help of Microsoft Office software package. RESULTS: Analysis of key regional medico-demographic indicators of Krasnodar Krai for the analyzed period from 2018 to 2020 has made it possible to identify population growth. These indicators include the increase in migration, the number of children, the population under working age, women of childbearing age, the decrease in the total and total fertility rates, the population of working age, and the increase in the overall mortality rate, which includes the working age and population loss. Diseases of the circulatory system, the nervous system, and neoplasm took the largest share in the structure of mortality in 2020. In the structure of mortality, diseases of the circulatory system, nervous system, and neoplasm took the largest share. One of the reasons for the increase in total mortality in 2020 was the death rate from COVID-19. CONCLUSIONS: The analysis of the main medico-demographic indicators as one of the key components of public health of Krasnodar Krai for 20182020 has been conducted.