107 results on '"Bell J. T."'
Search Results
2. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease
- Author
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Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.
- Published
- 2020
- Full Text
- View/download PDF
3. Methylmercury Concentrations and Production Rates across a Trophic Gradient in the Northern Everglades
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Gilmour, Cynthia C., Riedel, G. S., Ederington, M. C., Bell, J. T., Benoit, J. M., Gill, G. A., and Stordal, M. C.
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- 1998
4. A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts
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Nogal, A, Tettamanzi, F, Dong, Q, Louca, P, Visconti, A, Christiansen, C, Breuninger, T, Linseisen, J, Grallert, H, Wawro, N, Asnicar, F, Wong, K, Baleanu, A, Michelotti, G, Segata, N, Falchi, M, Peters, A, Franks, P, Bagnardi, V, Spector, T, Bell, J, Gieger, C, Valdes, A, Menni, C, Nogal A., Tettamanzi F., Dong Q., Louca P., Visconti A., Christiansen C., Breuninger T., Linseisen J., Grallert H., Wawro N., Asnicar F., Wong K., Baleanu A. -F., Michelotti G. A., Segata N., Falchi M., Peters A., Franks P. W., Bagnardi V., Spector T. D., Bell J. T., Gieger C., Valdes A. M., Menni C., Nogal, A, Tettamanzi, F, Dong, Q, Louca, P, Visconti, A, Christiansen, C, Breuninger, T, Linseisen, J, Grallert, H, Wawro, N, Asnicar, F, Wong, K, Baleanu, A, Michelotti, G, Segata, N, Falchi, M, Peters, A, Franks, P, Bagnardi, V, Spector, T, Bell, J, Gieger, C, Valdes, A, Menni, C, Nogal A., Tettamanzi F., Dong Q., Louca P., Visconti A., Christiansen C., Breuninger T., Linseisen J., Grallert H., Wawro N., Asnicar F., Wong K., Baleanu A. -F., Michelotti G. A., Segata N., Falchi M., Peters A., Franks P. W., Bagnardi V., Spector T. D., Bell J. T., Gieger C., Valdes A. M., and Menni C.
- Abstract
Prediabetes is a metabolic condition associated with gut mi-crobiome composition, although mechanisms remain elu-sive. We searched for fecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individuals with IFG and 1,105 healthy individuals from the UK Adult Twin Registry (TwinsUK). We used the Cooperative Health Research in the Region of Augsburg (KORA) cohort (318 IFG individuals, 689 healthy individuals) to replicate our findings. We linearly combined eight IFG-positively associated metabolites (1-methylxantine, nicoti-nate, glucuronate, uridine, cholesterol, serine, caffeine, and protoporphyrin IX) into an IFG-metabolite score, which was significantly associated with higher odds ratios (ORs) for IFG (TwinsUK: OR 3.9 [95% CI 3.02–5.02], P < 0.0001, KORA: OR 1.3 [95% CI 1.16–1.52], P < 0.0001) and incident type 2 diabetes (T2D; TwinsUK: hazard ratio 4 [95% CI 1.97–8], P = 0.0002). Although these are host-produced me-tabolites, we found that the gut microbiome is strongly associated with their fecal levels (area under the curve >70%). Abundances of Faecalibacillus intestinalis, Dorea formicigenerans, Ruminococcus torques, and Dorea sp. AF24-7LB were positively associated with IFG, and such associations were partially mediated by 1-methylxanthine and nicotinate (variance accounted for mean 14.4% [SD 5.1], P < 0.05). Our results suggest that the gut microbiome is linked to prediabetes not only via the production of microbial metabolites but also by affecting intestinal absorption/excretion of host-produced metabolites and xenobiotics, which are correlated with the risk of IFG. Fecal metabolites enable modeling of another mechanism of gut microbiome effect on prediabetes and T2D onset.
- Published
- 2023
5. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
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Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), Järvelin, M.-R. (Marjo-Riitta), Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), and Järvelin, M.-R. (Marjo-Riitta)
- Abstract
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.
- Published
- 2022
6. Follow-up investigation of 12 proposed linkage regions in multiple sclerosis
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Herrera, B M, Cader, M Z, Dyment, D A, Bell, J T, Ramagopalan, S V, Lincoln, M R, Orton, S, Chao, M J, Sadovnick, A D, and Ebers, G C
- Published
- 2006
- Full Text
- View/download PDF
7. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease
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Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., Claesson, M. J., Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.
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- 2020
8. Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans
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Wiltshire, S., Bell, J. T., Groves, C. J., Dina, C., Hattersley, A. T., Frayling, T. M., Walker, M., Hitman, G. A., Vaxillaire, M., Farrall, M., Froguel, P., and McCarthy, M. I.
- Published
- 2006
9. A DNA methylation biomarker of alcohol consumption
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Liu, C, Marioni, R E, Hedman, Åsa K, Pfeiffer, L, Tsai, P-C, Reynolds, L M, Just, A C, Duan, Q, Boer, C G, Tanaka, T, Elks, C E, Aslibekyan, S, Brody, J A, Kühnel, B, Herder, C, Almli, L M, Zhi, D, Wang, Y, Huan, T, Yao, C, Mendelson, M M, Joehanes, R, Liang, L, Love, S-A, Guan, W, Shah, S, McRae, A F, Kretschmer, A, Prokisch, H, Strauch, K, Peters, A, Visscher, P M, Wray, N R, Guo, X, Wiggins, K L, Smith, A K, Binder, E B, Ressler, K J, Irvin, M R, Absher, D M, Hernandez, D, Ferrucci, L, Bandinelli, S, Lohman, K, Ding, J, Trevisi, L, Gustafsson, Stefan, Sandling, Johanna K., Stolk, L, Uitterlinden, A G, Yet, I, Castillo-Fernandez, J E, Spector, T D, Schwartz, J D, Vokonas, P, Lind, Lars, Li, Y, Fornage, M, Arnett, D K, Wareham, N J, Sotoodehnia, N, Ong, K K, van Meurs, J B J, Conneely, K N, Baccarelli, A A, Deary, I J, Bell, J T, North, K E, Liu, Y, Waldenberger, M, London, S J, Ingelsson, Erik, Levy, D, Wareham, Nicholas [0000-0003-1422-2993], Ong, Kenneth [0000-0003-4689-7530], Apollo - University of Cambridge Repository, Erasmus MC other, Internal Medicine, and Epidemiology
- Subjects
Adult ,Male ,Alcohol Drinking ,Ethanol ,Black People ,DNA Methylation ,Middle Aged ,White People ,Epigenesis, Genetic ,Annan medicinsk grundvetenskap ,Genetics ,Humans ,CpG Islands ,Female ,Other Basic Medicine ,Alcohol-Related Disorders ,Biomarkers ,Aged ,Genome-Wide Association Study - Abstract
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (ntotal=13 317; 54% women; mean age across cohorts 42-76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples. We performed meta-analysis and variable selection in whole-blood samples of people of European ancestry (n=6926) and identified 144 CpGs that provided substantial discrimination (area under the curve=0.90-0.99) for current heavy alcohol intake (⩾42 g per day in men and ⩾28 g per day in women) in four replication cohorts. The ancestry-stratified meta-analysis in whole blood identified 328 (9643 European ancestry samples) and 165 (2423 African ancestry samples) alcohol-related CpGs at Bonferroni-adjusted PDe tio första författarna delar på förstaförfattarskapet. De sex sista författarna delar på sistaförfattarskapet.
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- 2018
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- View/download PDF
10. A DNA methylation biomarker of alcohol consumption
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Liu, C, Marioni, R E, Hedman, Å K, Pfeiffer, L, Tsai, P-C, Reynolds, L M, Just, A C, Duan, Q, Boer, C G, Tanaka, T, Elks, C E, Aslibekyan, S, Brody, J A, Kühnel, B, Herder, C, Almli, L M, Zhi, D, Wang, Y, Huan, T, Yao, C, Mendelson, M M, Joehanes, R, Liang, L, Love, S-A, Guan, W, Shah, S, McRae, A F, Kretschmer, A, Prokisch, H, Strauch, K, Peters, A, Visscher, P M, Wray, N R, Guo, X, Wiggins, K L, Smith, A K, Binder, E B, Ressler, K J, Irvin, M R, Absher, D M, Hernandez, D, Ferrucci, L, Bandinelli, S, Lohman, K, Ding, J, Trevisi, L, Gustafsson, S, Sandling, J H, Stolk, L, Uitterlinden, A G, Yet, I, Castillo-Fernandez, J E, Spector, T D, Schwartz, J D, Vokonas, P, Lind, L, Li, Y, Fornage, M, Arnett, D K, Wareham, N J, Sotoodehnia, N, Ong, K K, van Meurs, J B J, Conneely, K N, Baccarelli, A A, Deary, I J, Bell, J T, North, K E, Liu, Y, Waldenberger, M, London, S J, Ingelsson, E, and Levy, D
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ddc - Published
- 2016
11. High temperature equilibrium measurements of the yttrium-hydrogen isotope (H2, D2, T2) systems.
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Begun, G. M., Land, J. F., and Bell, J. T.
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- 1980
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12. A DNA methylation biomarker of alcohol consumption
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Liu, C, primary, Marioni, R E, additional, Hedman, Å K, additional, Pfeiffer, L, additional, Tsai, P-C, additional, Reynolds, L M, additional, Just, A C, additional, Duan, Q, additional, Boer, C G, additional, Tanaka, T, additional, Elks, C E, additional, Aslibekyan, S, additional, Brody, J A, additional, Kühnel, B, additional, Herder, C, additional, Almli, L M, additional, Zhi, D, additional, Wang, Y, additional, Huan, T, additional, Yao, C, additional, Mendelson, M M, additional, Joehanes, R, additional, Liang, L, additional, Love, S-A, additional, Guan, W, additional, Shah, S, additional, McRae, A F, additional, Kretschmer, A, additional, Prokisch, H, additional, Strauch, K, additional, Peters, A, additional, Visscher, P M, additional, Wray, N R, additional, Guo, X, additional, Wiggins, K L, additional, Smith, A K, additional, Binder, E B, additional, Ressler, K J, additional, Irvin, M R, additional, Absher, D M, additional, Hernandez, D, additional, Ferrucci, L, additional, Bandinelli, S, additional, Lohman, K, additional, Ding, J, additional, Trevisi, L, additional, Gustafsson, S, additional, Sandling, J H, additional, Stolk, L, additional, Uitterlinden, A G, additional, Yet, I, additional, Castillo-Fernandez, J E, additional, Spector, T D, additional, Schwartz, J D, additional, Vokonas, P, additional, Lind, L, additional, Li, Y, additional, Fornage, M, additional, Arnett, D K, additional, Wareham, N J, additional, Sotoodehnia, N, additional, Ong, K K, additional, van Meurs, J B J, additional, Conneely, K N, additional, Baccarelli, A A, additional, Deary, I J, additional, Bell, J T, additional, North, K E, additional, Liu, Y, additional, Waldenberger, M, additional, London, S J, additional, Ingelsson, E, additional, and Levy, D, additional
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- 2016
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13. Genetic studies of body mass index yield new insights for obesity biology
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Locke, A, Kahali, B, Berndt, S, Justice, A, Pers, T, Day, F, Powell, C, Vedantam, S, Buchkovich, M, Yang, J, Croteau-Chonka, D, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Magi, R, Randall, J, Winkler, T, Wood, A, Workalemahu, T, Faul, J, Smith, J, Zhao, J, Zhao, W, Chen, J, Fehrmann, R, Hedman, A, Karjalainen, J, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bolton, J, Bragg-Gresham, J, Buyske, S, Demirkan, A, Deng, G, Ehret, G, Feenstra, B, Feitosa, M, Fischer, K, Goel, A, Gong, J, Jackson, A, Kanoni, S, Kleber, M, Kristiansson, K, Lim, U, Lotay, V, Mangino, M, Leach, I, Medina-Gomez, C, Medland, S, Nalls, M, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Shungin, D, Stancakova, A, Strawbridge, R, Sung, Y, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S, van Setten, J, Van Vliet-Ostaptchouk, J, Wang, Z, Yengo, L, Zhang, W, Isaacs, A, Albrecht, E, Arnlov, J, Arscott, G, Attwood, A, Bandinelli, S, Barrett, A, Bas, I, Bellis, C, Bennett, A, Berne, C, Blagieva, R, Bluher, M, Bohringer, S, Bonnycastle, L, Bottcher, Y, Boyd, H, Bruinenberg, M, Caspersen, I, Chen, Y, Clarke, R, Daw, E, de Craen, A, Delgado, G, Dimitriou, M, Doney, A, Eklund, N, Estrada, K, Eury, E, Folkersen, L, Fraser, R, Garcia, M, Geller, F, Giedraitis, V, Gigante, B, Go, A, Golay, A, Goodall, A, Gordon, S, Gorski, M, Grabe, H, Grallert, H, Grammer, T, Grassler, J, Gronberg, H, Groves, C, Gusto, G, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heard-Costa, N, Helmer, Q, Hengstenberg, C, Holmen, O, Hottenga, J, James, A, Jeff, J, Johansson, A, Jolley, J, Juliusdottir, T, Kinnunen, L, Koenig, W, Koskenvuo, M, Kratzer, W, Laitinen, J, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindstrom, J, Lo, K, Lobbens, S, Lorbeer, R, Lu, Y, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Mclachlan, S, Menni, C, Merger, S, Mihailov, E, Milani, L, Moayyeri, A, Monda, K, Morken, M, Mulas, A, Muller, G, Muller-Nurasyid, M, Musk, A, Nagaraja, R, Nothen, M, Nolte, I, Pilz, S, Rayner, N, Renstrom, F, Rettig, R, Ried, J, Ripke, S, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, F, Scott, W, Seufferlein, T, Shi, J, Smith, A, Smolonska, J, Stanton, A, Steinthorsdottir, V, Stirrups, K, Stringham, H, Sundstrom, J, Swertz, M, Swift, A, Syvanen, A, Tan, S, Tayo, B, Thorand, B, Thorleifsson, G, Tyrer, J, Uh, H, Vandenput, L, Verhulst, F, Vermeulen, S, Verweij, N, Vonk, J, Waite, L, Warren, H, Waterworth, D, Weedon, M, Wilkens, L, Willenborg, C, Wilsgaard, T, Wojczynski, M, Wong, A, Wright, A, Zhang, Q, Brennan, E, Choi, M, Dastani, Z, Drong, A, Eriksson, P, Franco-Cereceda, A, Gadin, J, Gharavi, A, Goddard, M, Handsaker, R, Huang, J, Karpe, F, Kathiresan, S, Keildson, S, Kiryluk, K, Kubo, M, Lee, J, Liang, L, Lifton, R, Ma, B, Mccarroll, S, Mcknight, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Okada, Y, Perry, J, Dorajoo, R, Reinmaa, E, Salem, R, Sandholm, N, Scott, R, Stolk, L, Takahashi, A, Van't Hooft, F, Vinkhuyzen, A, Westra, H, Zheng, W, Zondervan, K, Heath, A, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Bovet, P, Campbell, H, Caulfield, M, Cesana, G, Chakravarti, A, Chasman, D, Chines, P, Collins, F, Crawford, D, Cupples, L, Cusi, D, Danesh, J, de Faire, U, Den Ruijter, H, Dominiczak, A, Erbel, R, Erdmann, J, Eriksson, J, Farrall, M, Felix, S, Ferrannini, E, Ferrieres, J, Ford, I, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gejman, P, Gieger, C, Gottesman, O, Gudnason, V, Gyllensten, U, Hall, A, Harris, T, Hattersley, A, Hicks, A, Hindorff, L, Hingorani, A, Hofman, A, Homuth, G, Hovingh, G, Humphries, S, Hunt, S, Hypponen, E, Illig, T, Jacobs, K, Jarvelin, M, Jockel, K, Johansen, B, Jousilahti, P, Jukema, J, Jula, A, Kaprio, J, Kastelein, J, Keinanen-Kiukaanniemi, S, Kiemeney, L, Knekt, P, Kooner, J, Kooperberg, C, Kovacs, P, Kraja, A, Kumari, M, Kuusisto, J, Lakka, T, Langenberg, C, 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- Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
- Published
- 2015
14. Analysis of oxide coatings on steam-oxidized incoloy 800
- Author
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Bittner, H. F., Bell, J. T., Redman, J. D., Christie, W. H., and Eby, R. E.
- Published
- 1980
- Full Text
- View/download PDF
15. Tritium permeation through clean construction alloys
- Author
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Bell, J. T., Redman, J. D., and Bittner, H. F.
- Published
- 1979
- Full Text
- View/download PDF
16. Tritium permeability of nickel plated stainless steel 21-6-9 and of gold plated aluminum
- Author
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Bell, J. T. and Redman, J. D.
- Published
- 1983
- Full Text
- View/download PDF
17. Tritium permeation through clean incoloy 800 and sanicro 31 alloys and through steam oxidized incoloy 800
- Author
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Bell, J. T., Redman, J. D., and Bittner, H. P.
- Published
- 1980
- Full Text
- View/download PDF
18. Effects of ammoniation on aflatoxins in rations fed lactating cows
- Author
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Mckinney, John D., Cavanagh, George C., Bell, J. T., Hoversland, A. S., Nelson, D. M., Pearson, J., and Selkirk, R. J.
- Published
- 1973
- Full Text
- View/download PDF
19. Photochemistry of Aqueous Plutonium Solutions
- Author
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BELL, J. T., primary, TOTH, L. M., additional, and FRIEDMAN, H. A., additional
- Published
- 1983
- Full Text
- View/download PDF
20. Photochemistry of the Actinides
- Author
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TOTH, L. M., primary, BELL, J. T., additional, and FRIEDMAN, H. A., additional
- Published
- 1980
- Full Text
- View/download PDF
21. DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker
- Author
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Heyn, H., primary, Carmona, F. J., additional, Gomez, A., additional, Ferreira, H. J., additional, Bell, J. T., additional, Sayols, S., additional, Ward, K., additional, Stefansson, O. A., additional, Moran, S., additional, Sandoval, J., additional, Eyfjord, J. E., additional, Spector, T. D., additional, and Esteller, M., additional
- Published
- 2012
- Full Text
- View/download PDF
22. APEXRAD Documentation
- Author
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PHILLIPS LAB HANSCOM AFB MA, Bell, J. T., Gussenhoven, M. S., PHILLIPS LAB HANSCOM AFB MA, Bell, J. T., and Gussenhoven, M. S.
- Abstract
This technical report documents the APEXRAD software package developed by the Phillips Laboratory, Geophysics Directorate. APEXRAD is a utility that predicts satellite dose accumulation behind four different thicknesses of aluminum (either slab or hemisphere) for specified orbits. Dose accumulation is predicted using empirical dose rate models created using data measured on the APEX (Advanced Photovoltaic and Electronics Experiments) satellite which flew in a 362 by 2544 km elliptical orbit inclined at 700. These dose models have a higher position resolution at low altitudes than the previously released CRRESRAD models. The APEXRAD models give dose rates averaged over the entire APEX mission and for four different levels of magnetospheric disturbance, based on a 15 day (offset by 1 day) running average of linear magnetic activity index, Ap. APEXRAD is best applied to orbits with apogees less than 2500 km, perigees greater than 350 km and inclinations less than 600, for times during solar cycle minimum. It can be useful for orbits with higher inclinations or lower perigees, but the user must account for any dose that may be received outside the region covered by the model. For higher altitude orbits the use of CRRESRAD is recommended.
- Published
- 1997
23. ORNL review of TRUEX flowsheet proposed for deployment at the Rockwell Hanford Plutonium Finishing Plant
- Author
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Bond, W. D., primary, Bell, J. T., additional, Campbell, D. O., additional, and Collins, E. D., additional
- Published
- 1987
- Full Text
- View/download PDF
24. Formation of excited hydrogen atoms by charge transfer and dissociation. Progress report No. 12, December 1, 1975--November 1, 1976. [Summaries of research activities at Georgia Institute of Technology]
- Author
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Thomas, E. W., primary, Rausch, E. O., additional, Harriss, J. E., additional, and Bell, J. T., additional
- Published
- 1976
- Full Text
- View/download PDF
25. Americium product solidification and disposal
- Author
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Mailen, J. C., primary, Campbell, D. O., additional, Bell, J. T., additional, and Collins, E. D., additional
- Published
- 1987
- Full Text
- View/download PDF
26. Assessment of photochemical applications to specific stages in Savannah River Plant actinide reprocessing streams
- Author
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Toth, L. M., primary, Bell, J. T., additional, Mailen, J. C., additional, and Dodson, K. E., additional
- Published
- 1986
- Full Text
- View/download PDF
27. Super storms
- Author
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Bell, J. T., primary, Gussenhoven, M. S., additional, and Mullen, E. G., additional
- Published
- 1997
- Full Text
- View/download PDF
28. Analytic approximation for charge current and deposition by 0.1 to 100 MeV electrons in thick slabs
- Author
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Frederickson, A. R., primary, Bell, J. T., additional, and Beidl, E. A., additional
- Published
- 1995
- Full Text
- View/download PDF
29. Molten Salt Oxidation of Mixed Wastes: Separation of Radioactive Materials and Resource Conservation and Recovery Act (RCRA) Materials
- Author
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Bell, J. T., primary, Haas, P. A., additional, and Rudolph, J. C., additional
- Published
- 1995
- Full Text
- View/download PDF
30. Conference reports
- Author
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Bell, J. T., primary, Watson, J. S., additional, Hesper, Ilse, additional, Charlier, Roger H., additional, and Charlier, R. H., additional
- Published
- 1994
- Full Text
- View/download PDF
31. Multiple sclerosis susceptibility and the X chromosome.
- Author
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Herrera, B. M., Cader, M. Z., Dyment, D. A., Bell, J. T., DeLuca, G. C., Willer, C. J., Lincoln, M. R., Ramagopalan, S. V., Chao, M., Orton, S.-M., Sadovnick, A. D., and Ebers, G. C.
- Subjects
MULTIPLE sclerosis ,X chromosome ,GENETICS of disease susceptibility ,SEX factors in disease ,SEX chromosomes ,ETIOLOGY of diseases ,MEDICAL genetics - Abstract
Multiple sclerosis (MS) is a chronic autoimmune complex trait with strong evidence for a genetic component. A female gender bias is clear but unexplained and a maternal parent-of-origin effect has been described. X-linked transmission of susceptibility has been previously proposed, based on pedigree, association and linkage studies. We genotyped 726 relative pairs including 552 affected sib-pairs for 22 X-chromosome microsatellite markers and a novel dataset of 195 aunt-uncle/niece-nephew (AUNN) affected pairs for 18 markers. Parent-of-origin effects were explored by dividing AUNN families into likely maternal and paternal trait transmission. For the sib-pair dataset we were able to establish exclusion at a λ
s =1.9 for all markers using an exclusion threshold of LOD⩽-2. Similarly for the AUNN dataset, we established exclusion at λAV =1.9. For the combined dataset we estimate exclusion of λ=1.6. We did not identify significant linkage in either the sib-pairs or the AUNN dataset nor when datasets were stratified for the presence/absence of the HLA-DRB1*15 allele or for paternal or maternal transmission. This comprehensive scrutiny of the X-chromosome suggests that it is unlikely to harbour an independent susceptibility locus or one which interacts with the HLA. Complex interactions including epigenetic ones, and masking by balanced polymorphisms are mechanisms not excluded by the approach taken. [ABSTRACT FROM AUTHOR]- Published
- 2007
- Full Text
- View/download PDF
32. The Disproportionation of Pu4+ in Nitric Acid Solutions
- Author
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Toth, L. M., primary, Bell, J. T., additional, and Friedman, H. A., additional
- Published
- 1990
- Full Text
- View/download PDF
33. Potential for the Use of Hydrochloric Acid in Fission Reactor Fuel Recycle.
- Author
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Mailen, J. C. and Bell, J. T.
- Published
- 1987
- Full Text
- View/download PDF
34. A Dilatometer Method for the Precision Measurement of the Densities of Liquids to 400°C and 352 kg/cm2.
- Author
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Bell, J. T., Biggers, R. E., Rogers, T. G., and Rom, A. M.
- Published
- 1969
- Full Text
- View/download PDF
35. The Disproportionation of Pu4+in Nitric Acid Solutions
- Author
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Toth, L. M., Bell, J. T., and Friedman, H. A.
- Published
- 1990
- Full Text
- View/download PDF
36. Low Altitude Dose Measurements from APEX, CRRES and DMSP
- Author
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Mullen, E. G., Gussenhoven, M. S., Bell, J. T., Madden, D., Holeman, E., and Delorey, D.
- Published
- 1998
- Full Text
- View/download PDF
37. Photo and Radiation Chemistry in Nuclear Fuel Reprocessin
- Author
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BELL, J. T. and TOTH, L. M.
- Published
- 1978
- Full Text
- View/download PDF
38. Methylmercury concentrations and production rates across a trophic gradient in the northern Everglades
- Author
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Cynthia Gilmour, Riedel, G. S., Ederington, M. C., Bell, J. T., Benoit, J. M., Gill, G. A., and Stordal, M. C.
39. Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
- Author
-
Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., Bell, J. T., Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., and Bell, J. T.
- Abstract
Background Smoking remains one of the leading preventable causes of death. Smoking leaves a strong signature on the blood methylome as shown in multiple studies using the Infinium HumanMethylation450 BeadChip. Here, we explore novel blood methylation smoking signals on the Illumina MethylationEPIC BeadChip (EPIC) array, which also targets novel CpG-sites in enhancers. Method A smoking-methylation meta-analysis was carried out using EPIC DNA methylation profiles in 1407 blood samples from four UK population-based cohorts, including the MRC National Survey for Health and Development (NSHD) or 1946 British birth cohort, the National Child Development Study (NCDS) or 1958 birth cohort, the 1970 British Cohort Study (BCS70), and the TwinsUK cohort (TwinsUK). The overall discovery sample included 269 current, 497 former, and 643 never smokers. Replication was pursued in 3425 trans-ethnic samples, including 2325 American Indian individuals participating in the Strong Heart Study (SHS) in 1989–1991 and 1100 African-American participants in the Genetic Epidemiology Network of Arteriopathy Study (GENOA). Results Altogether 952 CpG-sites in 500 genes were differentially methylated between smokers and never smokers after Bonferroni correction. There were 526 novel smoking-associated CpG-sites only profiled by the EPIC array, of which 486 (92%) replicated in a meta-analysis of the American Indian and African-American samples. Novel CpG sites mapped both to genes containing previously identified smoking-methylation signals and to 80 novel genes not previously linked to smoking, with the strongest novel signal in SLAMF7. Comparison of former versus never smokers identified that 37 of these sites were persistently differentially methylated after cessation, where 16 represented novel signals only profiled by the EPIC array. We observed a depletion of smoking-associated signals in CpG islands and an e
40. Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
- Author
-
Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., Bell, J. T., Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., and Bell, J. T.
- Abstract
Background Smoking remains one of the leading preventable causes of death. Smoking leaves a strong signature on the blood methylome as shown in multiple studies using the Infinium HumanMethylation450 BeadChip. Here, we explore novel blood methylation smoking signals on the Illumina MethylationEPIC BeadChip (EPIC) array, which also targets novel CpG-sites in enhancers. Method A smoking-methylation meta-analysis was carried out using EPIC DNA methylation profiles in 1407 blood samples from four UK population-based cohorts, including the MRC National Survey for Health and Development (NSHD) or 1946 British birth cohort, the National Child Development Study (NCDS) or 1958 birth cohort, the 1970 British Cohort Study (BCS70), and the TwinsUK cohort (TwinsUK). The overall discovery sample included 269 current, 497 former, and 643 never smokers. Replication was pursued in 3425 trans-ethnic samples, including 2325 American Indian individuals participating in the Strong Heart Study (SHS) in 1989–1991 and 1100 African-American participants in the Genetic Epidemiology Network of Arteriopathy Study (GENOA). Results Altogether 952 CpG-sites in 500 genes were differentially methylated between smokers and never smokers after Bonferroni correction. There were 526 novel smoking-associated CpG-sites only profiled by the EPIC array, of which 486 (92%) replicated in a meta-analysis of the American Indian and African-American samples. Novel CpG sites mapped both to genes containing previously identified smoking-methylation signals and to 80 novel genes not previously linked to smoking, with the strongest novel signal in SLAMF7. Comparison of former versus never smokers identified that 37 of these sites were persistently differentially methylated after cessation, where 16 represented novel signals only profiled by the EPIC array. We observed a depletion of smoking-associated signals in CpG islands and an e
41. Steam Oxidation of Fe‐32% Ni‐23% Cr Alloys with Manganese and Carbon
- Author
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Bittner, H. F., primary, Bell, J. T., additional, and Land, J. F., additional
- Published
- 1980
- Full Text
- View/download PDF
42. ChemInform Abstract: PHOTOREDUCTION OF THE URANYL ION WITH ARGON LASER LIGHT AND ETHANOL. III. PHOTOCHEMICAL REDUCTION OF DIOXOURANIUM(VI) TO DIOXOURANIUM(V)
- Author
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BELL, J. T., primary and BILLINGS, M. R., additional
- Published
- 1976
- Full Text
- View/download PDF
43. ChemInform Abstract: STEAM OXIDATION OF FE-32% NI-23% CR ALLOYS WITH MANGANESE AND CARBON
- Author
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BITTNER, H. F., primary, BELL, J. T., additional, and LAND, J. F., additional
- Published
- 1980
- Full Text
- View/download PDF
44. ChemInform Abstract: HIGH-TEMPERATURE EQUILIBRIUM MEASUREMENTS OF THE YTTRIUM-HYDROGEN ISOTOPE (HYDROGEN, DEUTERIUM, TRITIUM) SYSTEMS
- Author
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BEGUN, G. M., primary, LAND, J. F., additional, and BELL, J. T., additional
- Published
- 1980
- Full Text
- View/download PDF
45. ChemInform Abstract: PHOTOCHEMICAL REACTIONS OF AQUEOUS PLUTONIUM SYSTEMS
- Author
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BELL, J. T., primary and FRIEDMAN, H. A., additional
- Published
- 1976
- Full Text
- View/download PDF
46. ChemInform Abstract: PHOTOCHEMICAL REACTIONS OF AQUEOUS PLUTONIUM SYSTEMS. II
- Author
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FRIEDMAN, H. A., primary, TOTH, L. M., additional, and BELL, J. T., additional
- Published
- 1977
- Full Text
- View/download PDF
47. Permeation of hydrogen isotopes in nickel
- Author
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Bell, J. T., primary and Redman, J. D., additional
- Published
- 1978
- Full Text
- View/download PDF
48. LIST OF STAPHYLINIDÆ TAKEN AT BELLEVILLE, ONT
- Author
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Bell, J. T., primary
- Published
- 1885
- Full Text
- View/download PDF
49. PRACTICAL ENTOMOLOGY: “MOSS-HUNTING”
- Author
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Bell, J. T., primary
- Published
- 1883
- Full Text
- View/download PDF
50. AN IMPROVED METHOD FOR THE SCHULTZ CHOLESTEROL TEST
- Author
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WEBER, A. F., primary, PHILLIPS, M. G., additional, and BELL, J. T., additional
- Published
- 1956
- Full Text
- View/download PDF
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