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205 results on '"Belinsky, S. A."'

5. Genetic Associations and Architecture of Asthma-COPD Overlap:Chest

Author

John, C., Guyatt, A. L., Shrine, N., Packer, R., Olafsdottir, T. A., Liu, J., Hayden, L. P., Chu, S. H., Koskela, J. T., Luan, J., Li, X., Terzikhan, N., Xu, H., Bartz, T. M., Petersen, H., Leng, S., Belinsky, S. A., Cepelis, A., Hernández Cordero, A. I., Obeidat, M., Thorleifsson, G., Meyers, D. A., Bleecker, E. R., Sakoda, L. C., Iribarren, C., Tesfaigzi, Y., Gharib, S. A., Dupuis, J., Brusselle, G., Lahousse, L., Ortega, V. E., Jonsdottir, I., Sin, D. D., Bossé, Y., van den Berge, M., Nickle, D., Quint, J. K., Sayers, I., Hall, I. P., Langenberg, C., Ripatti, S., Laitinen, T., Wu, A. C., Lasky-Su, J., Bakke, P., Gulsvik, A., Hersh, C. P., Hayward, C., Langhammer, A., Brumpton, B., Stefansson, K., Cho, M. H., Wain, L. V., Tobin, M. D., John, C., Guyatt, A. L., Shrine, N., Packer, R., Olafsdottir, T. A., Liu, J., Hayden, L. P., Chu, S. H., Koskela, J. T., Luan, J., Li, X., Terzikhan, N., Xu, H., Bartz, T. M., Petersen, H., Leng, S., Belinsky, S. A., Cepelis, A., Hernández Cordero, A. I., Obeidat, M., Thorleifsson, G., Meyers, D. A., Bleecker, E. R., Sakoda, L. C., Iribarren, C., Tesfaigzi, Y., Gharib, S. A., Dupuis, J., Brusselle, G., Lahousse, L., Ortega, V. E., Jonsdottir, I., Sin, D. D., Bossé, Y., van den Berge, M., Nickle, D., Quint, J. K., Sayers, I., Hall, I. P., Langenberg, C., Ripatti, S., Laitinen, T., Wu, A. C., Lasky-Su, J., Bakke, P., Gulsvik, A., Hersh, C. P., Hayward, C., Langhammer, A., Brumpton, B., Stefansson, K., Cho, M. H., Wain, L. V., and Tobin, M. D.

Abstract

Background: Some people have characteristics of both asthma and COPD (asthma-COPD overlap), and evidence suggests they experience worse outcomes than those with either condition alone. Research Question: What is the genetic architecture of asthma-COPD overlap, and do the determinants of risk for asthma-COPD overlap differ from those for COPD or asthma? Study Design and Methods: We conducted a genome-wide association study in 8,068 asthma-COPD overlap case subjects and 40,360 control subjects without asthma or COPD of European ancestry in UK Biobank (stage 1). We followed up promising signals (P < 5 × 10 –6) that remained associated in analyses comparing (1) asthma-COPD overlap vs asthma-only control subjects, and (2) asthma-COPD overlap vs COPD-only control subjects. These variants were analyzed in 12 independent cohorts (stage 2). Results: We selected 31 independent variants for further investigation in stage 2, and discovered eight novel signals (P < 5 × 10 –8) for asthma-COPD overlap (meta-analysis of stage 1 and 2 studies). These signals suggest a spectrum of shared genetic influences, some predominantly influencing asthma (FAM105A, GLB1, PHB, TSLP), others predominantly influencing fixed airflow obstruction (IL17RD, C5orf56, HLA-DQB1). One intergenic signal on chromosome 5 had not been previously associated with asthma, COPD, or lung function. Subgroup analyses suggested that associations at these eight signals were not driven by smoking or age at asthma diagnosis, and in phenome-wide scans, eosinophil counts, atopy, and asthma traits were prominent. Interpretation: We identified eight signals for asthma-COPD overlap, which may represent loci that predispose to type 2 inflammation, and serious long-term consequences of asthma.

Published
2022

12. Lung Bronchial Epithelial Cells are HIV Targets for Proviral Genomic Integration

Author

Palsamy Periyasamy, Siddappa N. Byrareddy, Sundaram Ramakrishnan, Belinsky S, Carmen S. Tellez, Hitendra S. Chand, Dinesh Devadoss, Mohan L. Sopori, Arpan Acharya, Neerad C. Mishra, Kieu Do, Shilpa Buch, Shashi P. Singh, and Marko Manevski

Subjects
Lung, virus diseases, Provirus, Biology, Genome, CXCR4, Virology, chemistry.chemical_compound, Immune system, medicine.anatomical_structure, chemistry, medicine, Vorinostat, Gene, DNA, medicine.drug
Abstract

In the era of highly active anti-retroviral therapy (HAART), obstructive lung diseases (OLDs) are common among the people living with HIV (PLWH); however, the mechanism by which HIV induces OLDs is unclear. Although human bronchial epithelial cells (HBECs) express HIV coreceptors and are critical in regulating lung immune responses, their role in transmitting HIV remains unclear. Herein, we present evidence that HIV-1 infects normal HBECs and the viral DNA is integrated in the genome to establish the viral latency. To prove that HIV productively infects HBECs, we demonstrate: (a) along with CXCR4, HBECs express the HIV-receptor CD4, and are induced to express CCR5 by IL-13 treatment; (b) following infection with HIV, HBECs produce HIV-p24 and contain the latent HIV provirus, which is activated by endotoxin and/or vorinostat; (c) DNA from HIV-1 infected HBECs contains the HIV-specificgagandnefgenes, along withAlusequences, confirming the integration of HIV in the host DNA; (d) the lung epithelial cells of HIV-infected subjects and SHIV-infected cynomolgus macaques are positive for HIV-specific transcripts. Thus, these studies suggest that HIV establishes latency in lung epithelial cells, making them potential HIV reservoirs. The long-living lung epithelial cells, activated by commonly encountered lung infections, might represent an ideal HIV target/reservoir, contributing to OLDs and other HIV-associated lung comorbidities.

Published
2020

22. Estimation of parameters of low frequency electromagnetic fields in electric traction power installations

Author

Belinsky, S. O. and Kuznetsov, K. B.

Subjects
electromagnetic fields, standardization, 658.3-05 [УДК 621.311.4.013], электромагнитные поля, maximum permissible levels, предельно допустимые уровни, УДК 537.811, electrical personnel, 537.811 [УДК 612.014.426], нормирование, электротехнический персонал, тяговое электроснабжение, traction energy
Abstract

мируемые показатели предельно допустимых уровней напряженностей, воздействие которых создает риск вредного воздействия на организм человека. Оцениваются результаты измерения параметров напряженностей электромагнитных полей на рабочих местах электротехнического персонала. Показаны существенные особенности распространения электромагнитных полей. На основе анализа экспериментальных данных предлагаются пути совершенствования нормирования электромагнитных полей для электротехнического персонала тягового электроснабжения. Peculiar features of electromagnetic fields sources, standardized indicators of maximum permissible levels of tensions, the impact of which creates a risk of harmful effects on human body are discussed in the article. The results of measurement of electromagnetic field strengths in the working place of electrical personnel are evaluated. The essential features of electromagnetic fields extension are shown. Based on the analysis of experimental data different ways of improving the standardization of electromagnetic fields for electrical traction energy personnel are suggested. Белинский Станислав Олегович – кандидат технических наук, доцент, заведующий кафедрой «Техносферная безопасность, Уральский государственный университет путей сообщения, г. Екатеринбург. Область научных интересов – электроэнергетика, безопасность электротехнического персонала. E-mail: SBelinsky@usurt.ru Belinsky Stanislav Olegovich is a Candidate of Science (Engineering), an associate professor, a head of Technospheric Safety Department of the Ural State University of Railway Transport, Yekaterinburg. Research interests: power engineering, electrical personnel safety. E-mail: SBelinsky@usurt.ru. Кузнецов Константин Борисович – доктор технических наук, профессор, заведующий Учебным центром охраны труда и безопасности, Уральский государственный университет путей сообщения, г. Екатеринбург. Область научных интересов – электроэнергетика, электробиофизика, безопасность. E-mail: kkuz@r66.ru Kuznetsov Konstantin Borisovich is a Doctor of Science (Engineering), a Professor, a head of Training Centre for Occupational Safety and Security of the Ural State University of Railway Transport, Yekaterinburg. Research interests: power engineering, electrical biophysics, security. E-mail: kkuz@r66.ru

Published
2012

26. Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau

Author

Leng, S., primary, Picchi, M. A., additional, Liu, Y., additional, Thomas, C. L., additional, Willis, D. G., additional, Bernauer, A. M., additional, Carr, T. G., additional, Mabel, P. T., additional, Han, Y., additional, Amos, C. I., additional, Lin, Y., additional, Stidley, C. A., additional, Gilliland, F. D., additional, Jacobson, M. R., additional, and Belinsky, S. A., additional

Published
2013
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50. Reduced DNA-dependent protein kinase activity is associated with lung cancer.

Author

Auckley, D H, Crowell, R E, Heaphy, E R, Stidley, C A, Lechner, J F, Gilliland, F D, and Belinsky, S A

Abstract

Reduced DNA repair capacity of carcinogen-induced DNA damage is now thought to significantly influence inherent susceptibility to lung cancer. DNA-dependent protein kinase (DNA-PK) is a serine-threonine kinase activated by the presence of double-strand breaks in DNA that appears to play a major role in non-homologous recombination and transcriptional control. The purpose of this study was to determine whether DNA-PK activity varies among individuals and how this affects lung cancer risk. DNA-PK activity in peripheral mononuclear cells from individuals with lung cancer (n = 41) was compared with lung cancer-free controls (n = 41). Interindividual variability was seen within each group, however, significant differences (P = 0.03) in DNA-PK activity between cases and controls were seen when comparing the distribution of enzyme activity among these two groups. The percentages of cases and controls with DNA-PK activity in the ranges 2.5-5.0 and 7.6-10.0 units were 39 versus 20% and 7 versus 29%, respectively. The enzyme activity in peripheral mononuclear cells reflected that seen in bronchial epithelial cells, one progenitor cell for lung cancer, supporting the use of peripheral mononuclear cells for larger population-based studies of DNA-PK activity. Its role as a potential modifier for lung cancer risk was supported by the fact that cell growth in bronchial epithelial cells exposed to bleomycin was directly associated with enzyme activity. The results of this study demonstrate that reduced DNA-PK repair activity is associated with risk for lung cancer.

Published
2001
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