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7 results on '"Beliavskaia, Alexandra Y."'

1. Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa

Author

Pulford, Caisey V., Perez-Sepulveda, Blanca M., Canals, Rocío, Bevington, Jessica A., Bengtsson, Rebecca J., Wenner, Nicolas, Rodwell, Ella V., Kumwenda, Benjamin, Zhu, Xiaojun, Bennett, Rebecca J., Stenhouse, George E., Malaka De Silva, P., Webster, Hermione J., Bengoechea, Jose A., Dumigan, Amy, Tran-Dien, Alicia, Prakash, Reenesh, Banda, Happy C., Alufandika, Lovemore, Mautanga, Mike P., Bowers-Barnard, Arthur, Beliavskaia, Alexandra Y., Predeus, Alexander V., Rowe, Will P. M., Darby, Alistair C., Hall, Neil, Weill, François-Xavier, Gordon, Melita A., Feasey, Nicholas A., Baker, Kate S., and Hinton, Jay C. D.

Published
2021
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3. Chromosome-level genome assembly and structural variant analysis of two laboratory yeast strains from the Peterhof Genetic Collection lineage

Author

Barbitoff, Yury A, primary, Matveenko, Andrew G, additional, Matiiv, Anton B, additional, Maksiutenko, Evgeniia M, additional, Moskalenko, Svetlana E, additional, Drozdova, Polina B, additional, Polev, Dmitrii E, additional, Beliavskaia, Alexandra Y, additional, Danilov, Lavrentii G, additional, Predeus, Alexander V, additional, and Zhouravleva, Galina A, additional

Published
2021
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4. Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa

Author

Pulford, Caisey V., primary, Perez-Sepulveda, Blanca M., additional, Canals, Rocío, additional, Bevington, Jessica A., additional, Bengtsson, Rebecca J., additional, Wenner, Nicolas, additional, Rodwell, Ella V., additional, Kumwenda, Benjamin, additional, Zhu, Xiaojun, additional, Bennett, Rebecca J., additional, Stenhouse, George E., additional, Malaka De Silva, P., additional, Webster, Hermione J., additional, Bengoechea, Jose A., additional, Dumigan, Amy, additional, Tran-Dien, Alicia, additional, Prakash, Reenesh, additional, Banda, Happy C., additional, Alufandika, Lovemore, additional, Mautanga, Mike P., additional, Bowers-Barnard, Arthur, additional, Beliavskaia, Alexandra Y., additional, Predeus, Alexander V., additional, Rowe, Will P. M., additional, Darby, Alistair C., additional, Hall, Neil, additional, Weill, François-Xavier, additional, Gordon, Melita A., additional, Feasey, Nicholas A., additional, Baker, Kate S., additional, and Hinton, Jay C. D., additional

Published
2020
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7. Chromosome-level genome assembly and structural variant analysis of two laboratory yeast strains from the Peterhof Genetic Collection lineage.

Author

Barbitoff YA, Matveenko AG, Matiiv AB, Maksiutenko EM, Moskalenko SE, Drozdova PB, Polev DE, Beliavskaia AY, Danilov LG, Predeus AV, and Zhouravleva GA

Subjects
Chromosomes, DNA Transposable Elements, High-Throughput Nucleotide Sequencing, Laboratories, Protein Serine-Threonine Kinases, Sequence Analysis, DNA, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae Proteins
Abstract

Thousands of yeast genomes have been sequenced with both traditional and long-read technologies, and multiple observations about modes of genome evolution for both wild and laboratory strains have been drawn from these sequences. In our study, we applied Oxford Nanopore and Illumina technologies to assemble complete genomes of two widely used members of a distinct laboratory yeast lineage, the Peterhof Genetic Collection (PGC), and investigate the structural features of these genomes including transposable element content, copy number alterations, and structural rearrangements. We identified numerous notable structural differences between genomes of PGC strains and the reference S288C strain. We discovered a substantial enrichment of mid-length insertions and deletions within repetitive coding sequences, such as in the SCH9 gene or the NUP100 gene, with possible impact of these variants on protein amyloidogenicity. High contiguity of the final assemblies allowed us to trace back the history of reciprocal unbalanced translocations between chromosomes I, VIII, IX, XI, and XVI of the PGC strains. We show that formation of hybrid alleles of the FLO genes during such chromosomal rearrangements is likely responsible for the lack of invasive growth of yeast strains. Taken together, our results highlight important features of laboratory yeast strain evolution using the power of long-read sequencing., (© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.)

Published
2021
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