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4. UBA1 gene mutation in giant cell arteritis

Author

Rossignol, Julien, Marzac, Christophe, Dellal, Azeddine, Belfeki, Nabil, Jachiet, Vincent, Slaoui, Mounia, Benarroche, Davy, Georgin-Lavialle, Sophie, Solary, Eric, Hermine, Olivier, Fain, Olivier, and Mekinian, Arsène

Published
2022
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10. Benralizumab for eosinophilic granulomatosis with polyangiitis

Author

Cottu, Adrien, primary, Groh, Matthieu, additional, Desaintjean, Charlene, additional, Marchand-Adam, Sylvain, additional, Guillevin, Loïc, additional, Puechal, Xavier, additional, Beaumesnil, Stacy, additional, Lazaro, Estibaliz, additional, Samson, Maxime, additional, Taille, Camille, additional, Durel, Cécile-Audrey, additional, Diot, Elizabeth, additional, Nicolas, Sarah, additional, Guilleminault, Laurent, additional, Ebbo, Mikael, additional, Cathebras, Pascal, additional, Dupin, Clairelyne, additional, Yildiz, Halil, additional, Belfeki, Nabil, additional, Pugnet, Grégory, additional, Chauvin, Pierre, additional, Jouneau, Stephane, additional, Lifermann, Francois, additional, Martellosio, Jean-Philippe, additional, Cottin, Vincent, additional, and Terrier, Benjamin, additional

Published
2023
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14. Diagnostic and prognostic performance of positron emission tomography/computed tomography in eosinophilic fasciitis: An observational multicenter retrospective study

Author

Chevalier, Kevin, Bouaziz, Jean-David, Groh, Matthieu, Allali, Danièle, Belfeki, Nabil, Bourse, Nellie, Cazalets-Lacoste, Claire, Collot, Romain, Flamarion, Edouard, Lacombe, Valentin, Le Scornet, Tanguy, Mauhin, Wladimir, Michaud, Martin, Dupin, Nicolas, Kahn, Jean-Emmanuel, Mouthon, Luc, and Chaigne, Benjamin

Published
2024
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22. The Predictive Value of Cell Blood Count Parameters to Diagnose Pulmonary Embolism in Patients with SARS-CoV-2 Infection: A Case Control Study

Author

Strazzulla, Alessio, Abroug Ben Halima, Sarra, Chouchane, Ibrahim, Rezek, Marwa, Pinto Stiebler, Marcella, Hamrouni, Sarra, Maalaoui, Mohammad, Ghriss, Nouha, Guedec-Ghelfi, Renaud, Moini, Cyrus, Monchi, Mehran, and Belfeki, Nabil

Subjects
Microbiology (medical), mean platelet volume, severe acute respiratory syndrome-coronavirus 2, viruses, RM1-950, social sciences, Biochemistry, Microbiology, platelet-to-lymphocyte ratio, Article, body regions, coronavirus infectious disease-2019, Infectious Diseases, stomatognathic system, neutrophil-to-lymphocyte ratio, acute pulmonary embolism, Pharmacology (medical), Therapeutics. Pharmacology, General Pharmacology, Toxicology and Pharmaceutics
Abstract

Introduction: Acute pulmonary embolism (aPE) is frequently associated with coronavirus infectious disease-2019 (COVID-19) with an incidence of more than 16%. Among the new promising biomarkers of aPE, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) showed correlations with aPE prognosis. The aim of this study was to conduct an exploratory analysis to check the possible role of cell blood count (CBC) parameters as diagnostic and prognostic biomarkers of aPE in COVID-19 patients. Materials and Methods: A case control study was conducted. Two populations were compared: (i) patients hospitalised from 31 January 2020 to 30 June 2021 with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection and aPE confirmed at angio computed tomography (aCT) or pulmonary scintigraphy (COVID-19 aPE group); (ii) patients hospitalised from 31 January 2017 to 30 June 2021 without SARS-CoV-2 infection whose suspicion of aPE was excluded by aCT or pulmonary scintigraphy (no-aPE group). Results: Overall, 184 patients were included in the study, 83 in COVID-19 aPE group and 101 in no-aPE group. At the univariate analysis, COVID-19 patients with aPE had higher NLR, PLR, neutrophil and lymphocyte counts than patients without aPE (p < 0.05). No significant difference was found in mean platelet volume and platelet counts. No difference in mortality rate was detected. At the multivariate analysis, neutrophil and lymphocyte counts were both associated with diagnostic of aPE while no CBC parameters were associated with mortality at day#7. Conclusions: Neutrophiland lymphocyte counts could be predictors of the early detection of aPE in COVID-19 patients. The value of CBC indices as biomarkers of aPE in daily clinical practice needs to be investigated in further studies.

Published
2022
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24. Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared β-Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018)

Author

Strazzulla, Alessio, primary, Postorino, Maria Concetta, additional, Belfeki, Nabil, additional, Iordache, Laura, additional, de Pontfarcy, Astrid, additional, Pitsch, Aurelia, additional, Leroy, Pierre, additional, Jochmans, Sebastien, additional, Monchi, Mehran, additional, and Diamantis, Sylvain, additional

Published
2022
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26. Leg‐type form of idiopathic multicentric Castleman disease associated with severe lower extremity chronic venous/lymphatic disease

Author

Ballul, Thomas, primary, Belfeki, Nabil, additional, Masson, Adèle, additional, Meignin, Véronique, additional, Woerther, Paul‐Louis, additional, Martin, Antoine, additional, Poullot, Elsa, additional, Wargnier, Alain, additional, Fadlallah, Jehane, additional, Garzaro, Margaux, additional, Malphettes, Marion, additional, Fieschi, Claire, additional, Maisonobe, Lucas, additional, Bensekhri, Hayat, additional, Guillot, Hélène, additional, Bertinchamp, Rémi, additional, Jachiet, Marie, additional, Poirot, Justine, additional, Galicier, Lionel, additional, Oksenhendler, Eric, additional, and Boutboul, David, additional

Published
2021
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27. USAID Associated with Myeloid Neoplasm and VEXAS Syndrome: Two Differential Diagnoses of Suspected Adult Onset Still’s Disease in Elderly Patients

Author

Delplanque, Marion, primary, Aouba, Achille, additional, Hirsch, Pierre, additional, Fenaux, Pierre, additional, Graveleau, Julie, additional, Malard, Florent, additional, Roos-Weil, Damien, additional, Belfeki, Nabil, additional, Drevon, Louis, additional, Oganesyan, Artem, additional, Groh, Matthieu, additional, Mahévas, Matthieu, additional, Razanamahery, Jerome, additional, Maigne, Gwenola, additional, Décamp, Matthieu, additional, Miranda, Sébastien, additional, Quemeneur, Thomas, additional, Rossignol, Julien, additional, Sailler, Laurent, additional, Sébert, Marie, additional, Terriou, Louis, additional, Sevoyan, Anna, additional, Hakobyan, Yervand, additional, Georgin-Lavialle, Sophie, additional, and Mekinian, Arsène, additional

Published
2021
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30. Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

Author

Zayet, Souheil, primary, Zahra, Hajer, additional, Royer, Pierre-Yves, additional, Tipirdamaz, Can, additional, Mercier, Julien, additional, Gendrin, Vincent, additional, Lepiller, Quentin, additional, Marty-Quinternet, Solène, additional, Osman, Molka, additional, Belfeki, Nabil, additional, Toko, Lynda, additional, Garnier, Pauline, additional, Pierron, Alix, additional, Plantin, Julie, additional, Messin, Louise, additional, Villemain, Marc, additional, Bouiller, Kevin, additional, and Klopfenstein, Timothée, additional

Published
2021
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31. Coexistence of Acquired Hemophilia and Antiphospholipid Serology in Monoclonal Gammopathy Patient

Author

Belfeki,Nabil, Hamrouni,Sarra, Strazzulla,Alessio, and Diamantis,Sylvain

Subjects
hemic and lymphatic diseases, International Medical Case Reports Journal
Abstract

Nabil Belfeki, Sarra Hamrouni, Alessio Strazzulla, Sylvain Diamantis Department of Internal Medicine, Groupe Hospitalier Sud-Ile de France, Melun, 77000, FranceCorrespondence: Nabil BelfekiDepartment of Internal Medicine, Groupe Hospitalier Sud Ile de France, 77000, Melun Tel +33 1 81 74 17 04Fax +33 1 81 74 18 12Email belfeki.nabil@gmail.comAbstract: Acquired hemophilia is a rare coagulopathy with hemorrhage into the skin, muscle, or soft tissues and mucous membranes and caused by inhibitor antibodies, mainly against FVIII. We report a case of acquired hemophilia presenting with diffuse cutaneous hemorrhage and hemothorax. The patient was found to have acquired an FVIII inhibitor and a high titer of anti β 2 glycoprotein 1 IgG and IgM, and anticardiolipin IgM in the context of IgA kappa-type monoclonal gammopathy. He received 3 injections of recombinant factor VII (rFVIIa) and blood transfusion. He was started on steroids and oral cyclophosphamide for 6 weeks. Thromboprophylaxis with aspirin at 100 mg/day was started 3 months after discharge. Antiphospholipid antibodies remained positive after 3 months as well as prolonged aPTT, factor VIII raised at 100%, and the inhibitor was not detected. The association between acquired hemophilia and antiphospholipid antibodies is rare and its distinction is mandatory because clinical presentation ranges from massive hemorrhage to thrombosis.Keywords: acquired hemophilia, factor VIII deficiency, antiphospholipid antibodies, hemorrhage, treatment

Published
2021

35. Leg‐type form of idiopathic multicentric Castleman disease associated with severe lower extremity chronic venous/lymphatic disease.

Author

Ballul, Thomas, Belfeki, Nabil, de Masson, Adèle, Meignin, Véronique, Woerther, Paul‐Louis, Martin, Antoine, Poullot, Elsa, Wargnier, Alain, Fadlallah, Jehane, Garzaro, Margaux, Malphettes, Marion, Fieschi, Claire, Maisonobe, Lucas, Bensekhri, Hayat, Guillot, Hélène, Bertinchamp, Rémi, Jachiet, Marie, Poirot, Justine, Galicier, Lionel, and Oksenhendler, Eric

Published
2022
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36. Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared -Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018).

Author

Strazzulla, Alessio, Postorino, Maria Concetta, Belfeki, Nabil, Iordache, Laura, de Pontfarcy, Astrid, Pitsch, Aurelia, Leroy, Pierre, Jochmans, Sebastien, Monchi, Mehran, and Diamantis, Sylvain

Subjects
MULTIDRUG resistance in bacteria, INTENSIVE care units, METHICILLIN-resistant staphylococcus aureus, GRAM-positive bacteria, KLEBSIELLA pneumoniae, ALLERGIES, COHORT analysis
Abstract

Introduction: The risk of extended spectrum β-lactamase (ESBL) bacterial acquisition in patients with β-lactam allergy has been poorly investigated. In a previous study conducted over a 6-year long period (2007-2012), we found that patients with declared β-lactam allergy had a higher risk of ESBL bacterial carriage at admission in intensive care unit (ICU), but they had not a higher risk of ESBL bacterial acquisition. We present the final results of the study which was eventually conducted over a 12-year long period (2007-2018).Materials and Methods: The study included all patients admitted in ICU and receiving antibiotic treatment from January 2007 to December 2018. ESBL bacterial acquisition was the main clinical outcome. Mortality in ICU, multidrug resistant bacterial carriage at admission and discharge were the secondary outcomes.Results: Overall, 3332 patients were included, 132/3332 (3.9%) were labelled β-lactam allergic, while 3200/3332 (96.1%) did not presented β-lactam allergy. No significant difference in rates of ESBL acquisition was detected (4/132, 3% vs. 78/3200, 2.4%; p = 0.17). Patients with β-lactam allergy had higher rates of ESBL bacterial carriage at admission (19/132, 14.4% vs. 248/3200, 7.8%, p = 0.01) and at discharge (22/132, 16.7% vs. 351/3200, 11%, p = 0.04) than nonallergic patients. No differences in mortality, duration of hospitalization, and carriage of methicillin resistant Staphylococcus aureus were reported. Female gender was the only factor associated with β-lactam allergy at the multivariate analysis.Conclusions: This study confirms that patients with declared β-lactam allergy had not a higher risk of ESBL bacterial acquisition during hospitalization in ICU. However, they had a higher ESBL bacterial carriage at admission. [ABSTRACT FROM AUTHOR]

Published
2022
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39. IgA Vasculitis With Underlying Liver Cirrhosis: A French Nationwide Case Series of 20 Patients.

Author

Elhani, Ines, Pillebout, Evangéline, Terrier, Benjamin, Hankard, Antoine, Vrtovsnik, François, Jourde-Chiche, Noémie, Greillier, Sophie, Groh, Matthieu, Belfeki, Nabil, Bigot, Adrien, de Boysson, Hubert, Pageaux, Georges-Philippe, Raffray, Loïc, Urbanski, Geoffrey, Ollivier, Isabelle, Maillot, Francois, Aouba, Achille, Audemard-Verger, Alexandra, and Alexandra Audemard-Verger on behalf of the French Vasculitis Study Group (FVSG) and the HSPrognosis Group

Published
2021
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50. Hypereosinophilia and Hypereosinophilic Syndromes: First Findings From a Nationwide Multicenter Cohort.

Author

Lefèvre G, Bleuse S, Puyade M, Moulis G, Néel A, Abisror N, Baudet A, Bonnotte B, Dion J, Dossier A, Grall M, Lifermann F, Limal N, Lioger B, Machelart I, Mohr C, Outh R, Queyrel-Moranne V, Slama B, Tréfond L, Abou Chahla W, Ackerman F, Belfeki N, Berezne A, Blade JS, Bouderbala MA, Chebrek S, Cottin V, De Almeida S, De Masson A, Dezoteux F, Goulenok T, Jachiet V, Jouvray M, Latu I, Ledoult E, Leurs A, Lugosi M, Martin M, Melboucy-Belkhir S, Morati-Hafsaoui C, Quemeneur T, Rohmer J, Roy-Peaud F, Sanges S, Schleinitz N, Staumont-Salle D, Taillé C, Terriou L, Tieulie N, Koenga JDE, Schwarb L, Panel K, Kahn JE, and Groh M

Abstract

Background: Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample-size and/or follow-up duration are available., Methods: The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE/HES [HE/HES-R], idiopathic HES [HES-I], lymphocytic HES [HES-L], neoplastic HE/HES [HE/HES-N], HE of unknown significance [HE-US], as well as IgG4-related disease [IgG4RD] or ANCA-negative eosinophilic granulomatosis with polyangiitis [EGPA] overlaps). Patients are followed-up yearly. All data about final diagnosis, organ involvement assessments, and outcome profiles in HES-I were captured and analyzed centrally by HES expert centers., Results: From May 2019 to November 2023, 779 patients were included. For this preliminary analysis, 550 cases were available for centralized review (mean ± SD age: 56 ± 18 years, 42% of female patients). The final diagnoses were HES-I (47%), HE/HES-R (16%), HE-US (15%), HE/HES-N (7%), HE/HES-L (6%), IgG4RD (2%), and ANCA-negative EGPA (7%). In the 258 HES-I patients, outcome profiles were classified as follows: 16.3% had a "single-flare" without further relapse, 28.3% had a "relapsing-remitting" disease when there was at least a 6-month period free of symptoms between two flares, 46.1% had a "persistent disease" requiring continuous treatment to avoid relapses (9.3% remained unclassified because of insufficient follow-up)., Conclusions: The COHESion cohort is the first nationwide prospective multicenter study collecting data on the full spectrum of HE/HES disorders. This preliminary analysis confirms that idiopathic HES patients have various outcome profiles, suggesting different underlying pathophysiological mechanisms and the need of patient-specific management., Trial Registration: ClinicalTrials.gov identifier: NCT04018118., (© 2025 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Published
2025
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