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2. Vitamin D3 active metabolites as a countermeasure against disorders of calcium-phosphorus metabolism in hypokinetic rats.

Author

Ushakov AS, Spirichev VB, Belakovsky MS, Sergeev IN, Kaplansky AS, and Shvets VN

Subjects
24,25-Dihydroxyvitamin D 3, Animals, Calcitriol pharmacology, Dihydroxycholecalciferols pharmacology, Epiphyses growth & development, Femur growth & development, Growth Plate pathology, Male, Movement, Rats, Rats, Inbred Strains, Bone Development drug effects, Calcium Metabolism Disorders physiopathology, Cholecalciferol metabolism, Immobilization, Phosphorus Metabolism Disorders physiopathology
Abstract

Male Wistar rats that were experimentally hypokinetic were fed 24,25(OH)2D3 or 1,25(OH)2D3 separately or in combination to determine the effect on bone growth and on bone formation and resorption. It was shown that these parameters of bone metabolism are influenced by these metabolites of vitamin D3 by their effect on bone sensitivity to their activity and perhaps in the regulation of bone histogenesis.

Published
1984

3. Effect of 1 alpha-hydroxy-cholecalciferol and varying phosphorous content in the diet on calcium phosphorous metabolism in hypokinetic rats.

Author

Ushakov AS, Spirichev VB, Belakovsky MS, Blazhejevich NV, and Pozdnyakov AL

Subjects
Animals, Aorta metabolism, Bone and Bones metabolism, Calcinosis etiology, Kidney metabolism, Male, Rats, Calcium metabolism, Diet adverse effects, Hydroxycholecalciferols pharmacology, Motor Activity, Phosphorus metabolism
Abstract

Hypokinesia induces mineral changes, including changes in calcium and phosphorus metabolism, which involve their increased renal excretion, deposition in soft tissues, and development of osteoporosis. These experiments were designed in order to ascertain the role of active metabolites (hydroxy-cholecalciferol) and changes in phosphorus in the diet on calcium accumulation in bone, soft tissue, and renal calcinosis, and changes in calcium-phosphorus metabolism in rats during prolonged and severe hypokinesia.

Published
1980

4. Effect of vitamin and amino acid supplements on human performance during heavy mental and physical work.

Author

Ushakov AS, Myasnikov VI, Shestkov BP, Agureev AN, Belakovsky MS, and Rumyantseva MP

Subjects
Adult, Fatigue physiopathology, Galvanic Skin Response drug effects, Heart Rate drug effects, Humans, Male, Mathematics, Task Performance and Analysis, Work Capacity Evaluation, Amino Acids pharmacology, Mental Processes drug effects, Physical Exertion, Vitamins pharmacology
Abstract

This paper presents data describing the effects of vitamin and amino acid supplements on the health state and performance of men doing heavy mental and physical work. Experiments on seven test volunteers showed that a 20-d intake of a mixture of vitamins, amino acids, and mineral substances optimized the health state and increased the performance of test subjects doing heavy work.

Published
1978

6. Bone tissue of hypokinetic rats: effects of 24,25-dihydroxycholecalciferol and varying phosphorous content in the diet.

Author

Ushakov AS, Spirichev VB, Sergeev IN, Belakovsky MS, Blazhejevich NV, and Bogoslovsky NA

Subjects
24,25-Dihydroxyvitamin D 3, Alkaline Phosphatase blood, Animals, Bone Diseases drug therapy, Bone Diseases etiology, Bone and Bones analysis, Calcinosis etiology, Calcium blood, Calcium metabolism, Hypocalcemia etiology, Kidney analysis, Male, Osteoporosis etiology, Phosphorus metabolism, Rats, Rats, Inbred Strains, Restraint, Physical, Diet, Dihydroxycholecalciferols therapeutic use, Hypocalcemia drug therapy, Phosphorus administration & dosage
Abstract

Severe hypokinesia of rats given the diet with a ratio of Ca:P = 1:0.5-1:3 was accompanied by hypocalcemia, development of osteoporosis, and some intensification of renal calcinosis. The decrease of phosphorus consumption (Ca:P = 1:0.5-1:1) prevented a development of these changes in intact animals and increased bone mineralization in hypokinetic ones. Excessive phosphorus consumption (Ca:P = 1:3) produced hypocalcemia, hyperphosphatemia, and some osteoporotic changes in the bones of intact animals and intensified these changes with hypokinesia. Administration of 24,25-dihydroxycholecalciferol, an active metabolite of vitamin D3, at a dose of 1.25 micrograms/d prevented a development of bone disorders, thus effectively stimulating diaphyses and epiphyses mineralization and correcting hypocalcemia in hypokinetic rats. 24,25(OH)2D3 at the same dose did not intensify nephocalcinosis and produced no toxic symptoms with hypokinetic animals.

Published
1983

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