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1. Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

Author

Abraham, Sunje, Adang, Rob P.R., Aktas, Huseyin, Alderlieste, Yasser A., Aparicio-Pages, Maria N., Baak, L. (Bert) C., Baven-Pronk, Martine A.M.C., van der Beek, A. (Sander), Bekkering, Frank C., van Bergeijk, Jeroen D., Beuers, Ulrich, Beukema, Menno, de Boer, Wink, Boersma, Femke, Boonstra, Kirsten, ter Borg, Frank, ter Borg, Martijn J., ter Borg, Pieter C.J., de Bruin, Gijs J., Bus, Paul J., Cahen, Djuna L., Cazemier, Marcel, Cuperus, Frans J.C., van Dam, Lisette J.H., Denters, Maaike J., Drenth, Joost P.H., Epping, Ludger S.M., Erler, Nicole S., Flink, Hajo J., Friederich, Philip W., van Gerven, Nicole F.M., Gevers, Tom J.G., Hansen, Bettina E., van den Hazel, Sven J., van Hoek, Bart, van Hooff, Maria C., Hotho, Daphne M., Janssen, Harry L.A., de Jonge, Hendrik J.M., Jurgens, Matthias C., Kemenade, J.(Netty) van, Kerbert-Dreteler, Marjo J., Klemt-Kropp, Michael, Konings, Ingrid C.A.W., de Kort, Sander, Kuiper, Edith M.M., Kuyvenhoven, Johan P.H., van der Meer, Adriaan J., van Meer, Suzanne, Onderwater, Susanne L., Oterdoom, Leendert H., Ponsioen, Cyriel Y., van Putten, Paul G., van Rooij, Janne E., Roomer, Robert, Schmidt-Böhmer, Johannes, Schmittgens, Stephan, Schreuder, Tim C.M.A., Nicolaas, Jerome Sint, van Soest, Hanneke, Soufidi, Khalida, van Stiphout, Stephan H.C., Thio, Hans H.K., Tielemans, Merel M., Vandebosch, Sigrid, de Veer, Rozanne C., Veldt, Bart J., Verdonk, Robert C., Marleen de Vree, J., de Vries, Elsemieke, Vrieze, Anne, Vrolijk, Jan Maarten, van der Waaij, Laurens A., Werner, Ellen, de Wit, Ulrike, Wolfhagen, Frank H.J., van Hooff, Maria C.B., Baak, L.C., and Borg, Frank ter

Published
2024
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2. Incidence and prevalence of primary biliary cholangitis in the Netherlands – a nationwide cohort study

Author

de Veer, Rozanne C., primary, van Hooff, Maria C.B., additional, Werner, Ellen, additional, Beuers, Ulrich, additional, Drenth, Joost P.H., additional, Cuperus, Frans J.C., additional, van Hoek, Bart, additional, Veldt, Bart J., additional, Klemt-Kropp, Michael, additional, van Meer, Suzanne, additional, Verdonk, Robert C., additional, Flink, Hajo J., additional, Vrolijk, Jan Maarten, additional, Gevers, Tom J.G., additional, Ponsioen, Cyriel Y., additional, ter Borg, Martijn J., additional, Soufidi, Khalida, additional, Boersma, Femke, additional, de Jonge, Hendrik J.M., additional, Wolfhagen, Frank H.J., additional, Baak, L.C., additional, Onderwater, Susanne L., additional, van Bergeijk, Jeroen D., additional, van Putten, Paul G., additional, de Bruin, Gijs J., additional, Adang, Rob P.R., additional, Aparicio-Pages, Maria N., additional, de Boer, Wink, additional, Borg, Frank ter, additional, van Soest, Hanneke, additional, Janssen, Harry L.A., additional, Hansen, Bettina E., additional, Erler, Nicole S., additional, van der Meer, Adriaan J., additional, Abraham, Sunje, additional, Aktas, Huseyin, additional, Alderlieste, Yasser A., additional, Baak, L. (Bert) C., additional, Baven-Pronk, Martine A.M.C., additional, van der Beek, A.Sander, additional, Bekkering, Frank C., additional, Beukema, Menno, additional, Boonstra, Kirsten, additional, ter Borg, Frank, additional, ter Borg, Pieter C.J., additional, Bus, Paul J., additional, Cahen, Djuna L., additional, Cazemier, Marcel, additional, van Dam, Lisette J.H., additional, Denters, Maaike J., additional, Epping, Ludger S.M., additional, Friederich, Philip W., additional, van Gerven, Nicole F.M., additional, van den Hazel, Sven J., additional, van Hooff, Maria C., additional, Hotho, Daphne M., additional, Jurgens, Matthias C., additional, van Kemenade, J.Netty, additional, Kerbert-Dreteler, Marjo J., additional, Konings, Ingrid C.A.W., additional, de Kort, Sander, additional, Kuiper, Edith M.M., additional, Kuyvenhoven, Johan P.H., additional, Oterdoom, Leendert H., additional, van Rooij, Janne E., additional, Roomer, Robert, additional, Schmidt-Böhmer, Johannes, additional, Schmittgens, Stephan, additional, Schreuder, Tim C.M.A., additional, Nicolaas, Jerome Sint, additional, van Stiphout, Stephan H.C., additional, Thio, Hans H.K., additional, Tielemans, Merel M., additional, Vandebosch, Sigrid, additional, de Veer, Rozanne C., additional, Vree, J. Marleen de, additional, de Vries, Elsemieke, additional, Vrieze, Anne, additional, van der Waaij, Laurens A., additional, and de Wit, Ulrike, additional

Published
2024
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3. Endoscopic full-thickness resection of T1 colorectal cancers: a retrospective analysis from a multicenter Dutch eFTR registry

Author

Zwager, Liselotte W, Zwager, Liselotte W, Bastiaansen, Barbara A J, van der Spek, Bas W, Heine, Dimitri N, Schreuder, Ramon M, Perk, Lars E, Weusten, Bas L A M, Boonstra, Jurjen J, van der Sluis, Hedwig, Wolters, Hugo J, Bekkering, Frank C, Rietdijk, Svend T, Schwartz, Matthijs P, Nagengast, Wouter B, Ten Hove, W Rogier, Terhaar Sive Droste, Jochim S, Rando Munoz, Francisco J, Vlug, Marije S, Beaumont, Hanneke, Houben, Martin H M G, Seerden, Tom C J, de Wijkerslooth, Thomas R, Gielisse, Eric A R, Hazewinkel, Yark, de Ridder, Rogier, Straathof, Jan-Willem A, van der Vlugt, Manon, Koens, Lianne, Fockens, Paul, Dekker, Evelien, Dutch eFTR Grp, Zwager, Liselotte W, Zwager, Liselotte W, Bastiaansen, Barbara A J, van der Spek, Bas W, Heine, Dimitri N, Schreuder, Ramon M, Perk, Lars E, Weusten, Bas L A M, Boonstra, Jurjen J, van der Sluis, Hedwig, Wolters, Hugo J, Bekkering, Frank C, Rietdijk, Svend T, Schwartz, Matthijs P, Nagengast, Wouter B, Ten Hove, W Rogier, Terhaar Sive Droste, Jochim S, Rando Munoz, Francisco J, Vlug, Marije S, Beaumont, Hanneke, Houben, Martin H M G, Seerden, Tom C J, de Wijkerslooth, Thomas R, Gielisse, Eric A R, Hazewinkel, Yark, de Ridder, Rogier, Straathof, Jan-Willem A, van der Vlugt, Manon, Koens, Lianne, Fockens, Paul, Dekker, Evelien, and Dutch eFTR Grp

Abstract

BACKGROUND: Complete endoscopic resection and accurate histological evaluation for T1 colorectal cancer (CRC) are critical in determining subsequent treatment. Endoscopic full-thickness resection (eFTR) is a new treatment option for T1 CRC < 2 cm. We aimed to report clinical outcomes and short-term results.METHODS: Consecutive eFTR procedures for T1 CRC, prospectively recorded in our national registry between November 2015 and April 2020, were retrospectively analyzed. Primary outcomes were technical success and R0 resection. Secondary outcomes were histological risk assessment, curative resection, adverse events, and short-term outcomes.RESULTS: We included 330 procedures: 132 primary resections and 198 secondary scar resections after incomplete T1 CRC resection. Overall technical success, R0 resection, and curative resection rates were 87.0 % (95 % confidence interval [CI] 82.7 %-90.3 %), 85.6 % (95 %CI 81.2 %-89.2 %), and 60.3 % (95 %CI 54.7 %-65.7 %). Curative resection rate was 23.7 % (95 %CI 15.9 %-33.6 %) for primary resection of T1 CRC and 60.8 % (95 %CI 50.4 %-70.4 %) after excluding deep submucosal invasion as a risk factor. Risk stratification was possible in 99.3 %. The severe adverse event rate was 2.2 %. Additional oncological surgery was performed in 49/320 (15.3 %), with residual cancer in 11/49 (22.4 %). Endoscopic follow-up was available in 200/242 (82.6 %), with a median of 4 months and residual cancer in 1 (0.5 %) following an incomplete resection.CONCLUSIONS: eFTR is relatively safe and effective for resection of small T1 CRC, both as primary and secondary treatment. eFTR can expand endoscopic treatment options for T1 CRC and could help to reduce surgical overtreatment. Future studies should focus on long-term outcomes.

Published
2022

4. Endoscopic full-thickness resection of T1 colorectal cancers: a retrospective analysis from a multicenter Dutch eFTR registry.

Author

Zwager, Liselotte W., Bastiaansen, Barbara A. J., van der Spek, Bas W., Heine, Dimitri N., Schreuder, Ramon M., Perk, Lars E., Weusten, Bas L. A. M., Boonstra, Jurjen J., van der Sluis, Hedwig, Wolters, Hugo J., Bekkering, Frank C., Rietdijk, Svend T., Schwartz, Matthijs P., Nagengast, Wouter B., ten Hove, W. Rogier, Terhaar sive Droste, Jochim S., Rando Munoz, Francisco J., Vlug, Marije S., Beaumont, Hanneke, and Houben, Martin H. M. G.

Subjects
RESEARCH, CLINICAL trials, CARCINOGENESIS, RESEARCH methodology, RETROSPECTIVE studies, ACQUISITION of data, EVALUATION research, COLORECTAL cancer, TREATMENT effectiveness, COMPARATIVE studies, MENTAL health surveys
Abstract

Background: Complete endoscopic resection and accurate histological evaluation for T1 colorectal cancer (CRC) are critical in determining subsequent treatment. Endoscopic full-thickness resection (eFTR) is a new treatment option for T1 CRC < 2 cm. We aimed to report clinical outcomes and short-term results.Methods: Consecutive eFTR procedures for T1 CRC, prospectively recorded in our national registry between November 2015 and April 2020, were retrospectively analyzed. Primary outcomes were technical success and R0 resection. Secondary outcomes were histological risk assessment, curative resection, adverse events, and short-term outcomes.Results: We included 330 procedures: 132 primary resections and 198 secondary scar resections after incomplete T1 CRC resection. Overall technical success, R0 resection, and curative resection rates were 87.0 % (95 % confidence interval [CI] 82.7 %-90.3 %), 85.6 % (95 %CI 81.2 %-89.2 %), and 60.3 % (95 %CI 54.7 %-65.7 %). Curative resection rate was 23.7 % (95 %CI 15.9 %-33.6 %) for primary resection of T1 CRC and 60.8 % (95 %CI 50.4 %-70.4 %) after excluding deep submucosal invasion as a risk factor. Risk stratification was possible in 99.3 %. The severe adverse event rate was 2.2 %. Additional oncological surgery was performed in 49/320 (15.3 %), with residual cancer in 11/49 (22.4 %). Endoscopic follow-up was available in 200/242 (82.6 %), with a median of 4 months and residual cancer in 1 (0.5 %) following an incomplete resection.Conclusions: eFTR is relatively safe and effective for resection of small T1 CRC, both as primary and secondary treatment. eFTR can expand endoscopic treatment options for T1 CRC and could help to reduce surgical overtreatment. Future studies should focus on long-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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5. 493 ENDOSCOPIC FULL-THICKNESS RESECTION IS FEASIBLE FOR T1 COLORECTAL CANCERS - A DUTCH NATIONWIDE PROSPECTIVE REGISTRY COHORT STUDY

Author

Zwager, Liselotte W., primary, Bastiaansen, Barbara A., additional, van der Spek, Bas, additional, Heine, Dimitri, additional, Bronzwaer, Maxime, additional, Haasnoot, Krijn, additional, van der Sluis, Hedwig, additional, Perk, Lars, additional, Boonstra, Jurjen, additional, Rietdijk, Svend T., additional, Schwartz, Matthijs P., additional, Wolters, Hugo, additional, Weusten, Bas L., additional, Gilissen, Lennard, additional, Hove, Rogier ten, additional, Nagengast, Wouter B., additional, Bekkering, Frank C., additional, Terhaar sive Droste, Jochim S., additional, Fockens, Paul, additional, and Dekker, Evelien, additional

Published
2020
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6. Endoscopic full-thickness resection (eFTR) of colorectal lesions: results from the Dutch colorectal eFTR registry

Author

Zwager, Liselotte W., Zwager, Liselotte W., Bastiaansen, Barbara A. J., Bronzwaer, Maxime E. S., van der Spek, Bas W., Heine, G. Dimitri N., Haasnoot, Krijn J. C., van der Sluis, Hedwig, Perk, Lars E., Boonstra, Jurjen J., Rietdijk, Svend T., Wolters, Hugo J., Weusten, Bas L. A. M., Gilissen, Lennard P. L., Ten Hove, W. Rogier, Nagengast, Wouter B., Bekkering, Frank C., Schwartz, M. P., Droste, Jochim S. Terhaar Sive, Vlug, Marije S., Houben, Martin H. M. G., Munoz, Francisco J. Rando, Seerden, Tom C. J., Beaumont, Hanneke, de Ridder, Rogier, Dekker, Evelien, Fockens, Paul, Dutch eFTR Grp, Zwager, Liselotte W., Zwager, Liselotte W., Bastiaansen, Barbara A. J., Bronzwaer, Maxime E. S., van der Spek, Bas W., Heine, G. Dimitri N., Haasnoot, Krijn J. C., van der Sluis, Hedwig, Perk, Lars E., Boonstra, Jurjen J., Rietdijk, Svend T., Wolters, Hugo J., Weusten, Bas L. A. M., Gilissen, Lennard P. L., Ten Hove, W. Rogier, Nagengast, Wouter B., Bekkering, Frank C., Schwartz, M. P., Droste, Jochim S. Terhaar Sive, Vlug, Marije S., Houben, Martin H. M. G., Munoz, Francisco J. Rando, Seerden, Tom C. J., Beaumont, Hanneke, de Ridder, Rogier, Dekker, Evelien, Fockens, Paul, and Dutch eFTR Grp

Abstract

Background Endoscopic full-thickness resection (eFTR) is a minimally invasive resection technique that allows definite diagnosis and treatment for complex colorectal lesionsMethods Consecutive patients undergoing eFTR in 20 hospitals were prospectively included. The primary outcome was technical success, defined as macroscopic complete en bloc resection. Secondary outcomes were: clinical success, defined as tumor-free resection margins (R0 resection); full-thickness resection rate; and adverse events.Results Between July 2015 and October 2018, 367 procedures were included. Indications were difficult polyps (non-lifting sign and/or difficult location; n = 133), primary resection of suspected T1 colorectal cancer (CRC; n = 71), reresection after incomplete resection of T1 CRC (n = 150), and subepithelial tumors (n = 13). Technical success was achieved in 308 procedures (83.9%). In 21 procedures (5.7 %), eFTR was not performed because the lesion could not be reached or retracted into the cap. In the remaining 346 procedures, R0 resection was achieved in 285 (82.4%) and full-thickness resection in 288 (83.2%). The median diameter of resected specimens was 23mm. Overall adverse event rate was 9.3% (n = 34/367): 10 patients (2.7 %) required emergency surgery for five delayed and two immediate perforations and three cases of appendicitis.Conclusion eFTR is an effective and relatively safe en bloc resection technique for complex colorectal lesions with the potential to avoid surgery. Further studies assessing the role of eFTR in early CRC treatment with long-term outcomes are needed.

Published
2020

13. Changes in anti-viral effectiveness of interferon after dose reduction in chronic hepatitis c patients: a case control study

Author

Levi-Drummer Rachel S, Brouwer Johannes T, Neumann Avidan U, Bekkering Frank C, and Schalm Solko W

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background High dose interferon induction treatment of hepatitis C viral infection blocks viral production over 95%. Since dose reduction is often performed due to clinical considerations, the effect of dose reduction on hepatitis C virus kinetics was studied. Methods A new model that allowed longitudinal changes in the parameters of viral dynamics was used in a group of genotype-1 patients (N = 15) with dose reduction from 10 to 3 million units of interferon daily in combination with ribavirin, in comparison to a control group (N = 9) with no dose reduction. Results Dose reduction gave rise to a complex viral kinetic pattern, which could be only explained by a decrease in interferon effectiveness in blocking virion production. The benefit of the rapid initial viral decline following the high induction dose is lost after dose reduction. In addition, in some patients also the second phase viral decline slope, which is highly predictive of success of treatment, was impaired by the dose reduction resulting in smaller percentage of viral clearance in the dose reduction group. Conclusions These findings, while explaining the failure of many induction schedules, suggest that for genotype-1 patients induction therapy should be continued till HCVRNA negativity in serum in order to increase the sustained response rate for chronic hepatitis C.

Published
2001
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18. ENDOSCOPIC FULL-THICKNESS RESECTION IS FEASIBLE FOR T1 COLORECTAL CANCERS - A DUTCH NATIONWIDE PROSPECTIVE REGISTRY COHORT STUDY

Author

Zwager, Liselotte W., Bastiaansen, Barbara A., van der Spek, Bas, Heine, Dimitri, Bronzwaer, Maxime, Haasnoot, Krijn, van der Sluis, Hedwig, Perk, Lars, Boonstra, Jurjen, Rietdijk, Svend T., Schwartz, Matthijs P., Wolters, Hugo, Weusten, Bas L., Gilissen, Lennard, ten Hove, Rogier, Nagengast, Wouter B., Bekkering, Frank C., Droste, Jochim S. Terhaar sive, Fockens, Paul, Dekker, Evelien, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

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