1. Interrogating the promise of long-acting HIV pre-exposure prophylaxis.
- Author
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Pike, Carey and Bekker, Linda-Gail
- Subjects
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PRE-exposure prophylaxis , *HIV , *HIV infections , *HIV prevention - Abstract
Oral HIV pre-exposure prophylaxis (PrEP) is a well-established product that provides a safe and highly effective way for individuals to protect themselves against HIV infection. However, hopes of a significant reduction in HIV incidence have been disappointing because of low uptake, adherence challenges to a daily pill regimen, and consistently high discontinuation rates within 6 months of initiation. Long-acting agents have been long awaited for their potential to facilitate adherence and to offer a choice between PrEP products. As the first long-acting agents enter the market, with more poised to follow, questions around how to integrate long-acting agents into oral PrEP platforms, and what the potential advantages and pitfalls of this integration will be, now need to be considered. Pre-exposure prophylaxis (PrEP) for HIV prevention is safe and effective across multiple settings, but adherence challenges and high discontinuation rates with oral pill formulations have limited its potential impact. Strategies to overcome these challenges include first the use of long-acting PrEP formulations that offer discretion and reduced dose frequency, and second the hard-won effort to make oral PrEP delivery simplified, demedicalized, and differentiated. However, together these strategies are discordant because the integration of long-acting modalities into existing oral delivery systems risks PrEP remedicalization. The introduction of long-acting agents ushers in an era of PrEP choice in which PrEP users could theoretically select the PrEP product that is most suitable, acceptable, and accessible for them. However, the question of how to implement PrEP choice remains unanswered. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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