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1. Trends in Management and Outcomes of Type B Aortic Dissection: A Report From the International Registry of Aortic Dissection

Author

Trimarchi, S., primary, Gleason, T.G., additional, Brinster, D.R., additional, Bismuth, J., additional, Bossone, E., additional, Sundt, T.M., additional, Montgomery, D.G., additional, Pai, C.-W., additional, Bissacco, D., additional, de Beaufort, H.W.L., additional, Bavaria, J.E., additional, Mussa, F., additional, Bekeredjian, R., additional, Schermerhorn, M., additional, Pacini, D., additional, Myrmel, T., additional, Ouzounian, M., additional, Korach, A., additional, Chen, E.P., additional, Coselli, J.S., additional, Eagle, K.A., additional, and Patel, H.J., additional

Published
2024
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3. Interdisciplinary consensus on indications for transfemoral transcatheter aortic valve implantation (TF-TAVI): Joint Consensus Document of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte e.V. (ALKK) and cooperating Cardiac Surgery Departments

Author

von Scheidt, Wolfgang, Welz, A., Pauschinger, M., Fischlein, T., Schächinger, V., Treede, H., Zahn, R., Hennersdorf, M., Albes, J. M., Bekeredjian, R., Beyer, M., Brachmann, J., Butter, C., Bruch, L., Dörge, H., Eichinger, W., Franke, U. F. W., Friedel, N., Giesler, T., Gradaus, R., Hambrecht, R., Haude, M., Hausmann, H., Heintzen, M. P., Jung, W., Kerber, S., Mudra, H., Nordt, T., Pizzulli, L., Sack, F.-U., Sack, S., Schumacher, B., Schymik, G., Sechtem, U., Stellbrink, C., Stumpf, C., and Hoffmeister, H. M.

Published
2020
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4. Anticoagulatory treatment and clinical outcomes after transcatheter aortic valve implantation: results from 45,598 patients of the German Aortic Valve Registry (GARY)

Author

Hohmann, C, primary, Pfister, R, additional, Frerker, C, additional, Beckmann, A, additional, Walther, T, additional, Bleiziffer, S, additional, Ensminger, S, additional, Bekeredjian, R, additional, Seiffert, M, additional, Sinning, J M, additional, Moellmann, H, additional, Beyersdorf, F, additional, Herrmann, E, additional, Balaban, Ü, additional, and Kuhn, E W, additional

Published
2023
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7. Acute Kidney Injury in Patients Undergoing Surgery for Type A Acute Aortic Dissection.

Author

Arnaoutakis, G.J., Ogami, T., Patel, H.J., Pai, C.W., Woznicki, E.M., Brinster, D.R., Leshnower, B.G., Serna-Gallegos, D., Bekeredjian, R., Sundt, T.M., Shaffer, A.W., Peterson, M.D., Geuzebroek, G.S.C., Eagle, K.A., Trimarchi, S., Sultan, I., Arnaoutakis, G.J., Ogami, T., Patel, H.J., Pai, C.W., Woznicki, E.M., Brinster, D.R., Leshnower, B.G., Serna-Gallegos, D., Bekeredjian, R., Sundt, T.M., Shaffer, A.W., Peterson, M.D., Geuzebroek, G.S.C., Eagle, K.A., Trimarchi, S., and Sultan, I.

Abstract

01 april 2023, Item does not contain fulltext, BACKGROUND: Acute kidney injury (AKI) after repair of type A acute aortic dissection (TAAAD) has been shown to affect both short- and long-term outcomes. This study aimed to validate the impact of postoperative AKI on in-hospital and long-term outcomes in a large population of dissection patients presenting to multinational aortic centers. Additionally, we assessed risk factors for AKI including surgical details. METHODS: Patients undergoing surgical repair for TAAAD enrolled in the International Registry of Acute Aortic Dissection database were evaluated to determine the incidence and risk factors for the development of AKI. RESULTS: A total of 3307 patients were identified. There were 761 (23%) patients with postoperative AKI (AKI group) vs 2546 patients without (77%, non-AKI group). The AKI group had a higher rate of in-hospital mortality (n = 193, 25.4% vs n = 122, 4.8% in the non-AKI group, P < .001). Additional postoperative complications were also more common in the AKI group including postoperative cerebrovascular accident, reexploration for bleeding, and prolonged ventilation. Independent baseline characteristics associated with AKI included a history of hypertension, diabetes, chronic kidney disease, evidence of malperfusion on presentation, distal extent of dissection to abdominal aorta, and longer cardiopulmonary bypass time. Kaplan-Meier survival curves revealed decreased 5-year survival among the AKI group (P < .001). CONCLUSIONS: AKI occurs commonly after TAAAD repair and is associated with a significantly increased risk of operative and long-term mortality. In this large study using the International Registry of Acute Aortic Dissection database, several factors were elucidated that may affect risk of AKI.

Published
2023

10. TAVI versus SAVR in intermediate-risk patients with severe aortic stenosis and chronic kidney disease: a matched comparison in a subcohort from the GARY registry

Author

Mas-Peiro, S, primary, Faerber, G, additional, Herrmann, E, additional, Bauer, T, additional, Bleiziffer, S, additional, Bekeredjian, R, additional, Boening, A, additional, Frerker, C, additional, Beckmann, A, additional, Moellmann, H, additional, Ensminger, S, additional, Hamm, C, additional, Beyersdorf, F, additional, Fichtlscherer, S, additional, and Walther, T, additional

Published
2022
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11. Impact of coaptation gap location on procedural strategy and outcomes following tricuspid transcatheter edge-to-edge repair: insights from the TriClip bRIGHT study

Author

Donal, E, primary, Sitges, M, additional, Panis, V, additional, Schueler, R, additional, Lapp, H, additional, Moellmann, H, additional, Nickenig, G, additional, Bekeredjian, R, additional, Estevez, R, additional, Atmowihardjo, I, additional, Trusty, P, additional, and Lurz, P, additional

Published
2022
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12. Aufbau und Organisation von Herzinsuffizienz-Netzwerken (HF‑NETs) und Herzinsuffizienz-Einheiten („Heart Failure Units“, HFUs) zur Optimierung der Behandlung der akuten und chronischen Herzinsuffizienz: Gemeinsame Empfehlungen der DGK und der DGTHG zur Behandlung der Herzinsuffizienz

Author

Ertl, G., Angermann, C. E., Bekeredjian, R., Beyersdorf, F., Güder, G., Gummert, J., Katus, H. A., Kindermann, I., Pauschinger, M., Perings, S., Raake, P. W. J., Störk, S., Scheidt, W. von, Welz, S., and Böhm, M.

Published
2016
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16. Surgical Aortic Valve Replacement in Patients Aged 50 to 69 Years: Insights from the German Aortic Valve Registry (GARY)

Author

Vogt, F., additional, Santarpino, G., additional, Fujita, B., additional, Frerker, C., additional, Bauer, T., additional, Bekeredjian, R., additional, Bleiziffer, S., additional, Beckmann, A., additional, Möllmann, H., additional, Walther, T., additional, Beyersdorf, F., additional, Hamm, C., additional, Böning, A., additional, Baldus, S., additional, Ensminger, S., additional, Fischlein, T., additional, and Eckner, D., additional

Published
2022
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17. Refined prediction and validation of individual risk using machine learning in transcatheter aortic valve implantation: TAVI Risk Machine (TRIM) scores

Author

Leha, A, primary, Huber, C, additional, Friede, T, additional, Bauer, T, additional, Beckmann, A, additional, Bekeredjian, R, additional, Bleiziffer, S, additional, Herrmann, E, additional, Moellmann, H, additional, Walther, T, additional, Kutschka, I, additional, Hasenfuss, G, additional, Ensminger, S, additional, Frerker, C, additional, and Seidler, T, additional

Published
2021
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28. Impact of left atrial diameter on outcome in patients undergoing edge-to-edge mitral valve repair: results from the German TRAnscatheter Mitral valve Interventions registry (TRAMI)

Author

Iliadis, C, primary, Baldus, S, additional, Kalbacher, D, additional, Boekstegers, P, additional, Schillinger, W, additional, Ouarrak, T, additional, Zahn, R, additional, Butter, C, additional, Zuern, C.S, additional, Von Bardeleben, R.S, additional, Senges, J, additional, Bekeredjian, R, additional, Eggebrecht, H, additional, and Pfister, R, additional

Published
2020
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30. Clinical outcomes after surgical or transcatheter aortic valve replacement in patients with chronic kidney disease: an analysis in 29 893 patients from the German Aortic Valve Registry

Author

Mas-Peiro, S, primary, Faerber, G, additional, Bauer, T, additional, Bleiziffer, S, additional, Bekeredjian, R, additional, Boening, A, additional, Frerker, C, additional, Beckmann, A, additional, Moellmann, H, additional, Vasa-Nicotera, M, additional, Ensminger, S, additional, Hamm, C.W, additional, Beyersdorf, F, additional, Walther, T, additional, and Fichtlscherer, S, additional

Published
2020
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32. Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain

Author

Nikolakopoulou, P. Chatzigeorgiou, A. Kourtzelis, I. Toutouna, L. Masjkur, J. Arps-Forker, C. Poser, S.W. Rozman, J. Rathkolb, B. Aguilar-Pimentel, J.A. Becker, L. Klopstock, T. Treise, I. Busch, D.H. Beckers, J. Moreth, K. Bekeredjian, R. Garrett, L. Hölter, S.M. Zimprich, A. Wurst, W. Brommage, R. Amarie, O. Graw, J. Calzada-Wack, J. Neff, F. Zimmer, A. Östereicher, M. Steinkamp, R. Lengger, C. Maier, H. Stoeger, C. Leuchtenberger, S. Wolf, E. Klingenspor, M. Ollert, M. Schmidt-Weber, C. Fuchs, H. Gailus-Durner, V. Hrabe de Angelis, M. Tsata, V. Monasor, L.S. Troullinaki, M. Witt, A. Anastasiou, V. Chrousos, G. Yi, C.-X. García-Cáceres, C. Tschöp, M.H. Bornstein, S.R. Androutsellis-Theotokis, A. German Mouse Clinic Consortium

Abstract

Diabetes mellitus is a group of disorders characterized by prolonged high levels of circulating blood glucose. Type 1 diabetes is caused by decreased insulin production in the pancreas whereas type 2 diabetes may develop due to obesity and lack of exercise; it begins with insulin resistance whereby cells fail to respond properly to insulin and it may also progress to decreased insulin levels. The brain is an important target for insulin, and there is great interest in understanding how diabetes affects the brain. In addition to the direct effects of insulin on the brain, diabetes may also impact the brain through modulation of the inflammatory system. Here we investigate how perturbation of circulating insulin levels affects the expression of Hes3, a transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. Our data show that streptozotocin-induced β-cell damage, high fat diet, as well as metformin, a common type 2 diabetes medication, regulate Hes3 levels in the brain. This work suggests that Hes3 is a valuable biomarker helping to monitor the state of endogenous neural stem and progenitor cells in the context of diabetes mellitus. © 2018, The Author(s).

Published
2018

35. P2714Time-dependent myocardial necrosis in patients suffering from ST-elevation myocardial infarction without angiographic collateral flow visualized by cardiac magnetic resonance imaging

Author

Greulich, S, primary, Mayr, A, additional, Gloekler, S, additional, Seitz, A, additional, Birkmeier, S, additional, Schaeufele, T, additional, Bekeredjian, R, additional, Zuern, C S, additional, Geisler, T, additional, Klug, G, additional, Wahl, A, additional, Metzler, B, additional, Gawaz, M, additional, Windecker, S, additional, and Mahrholdt, H, additional

Published
2019
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37. Interdisciplinary consensus on indications for transfemoral transcatheter aortic valve implantation (TF-TAVI)

Author

von Scheidt, Wolfgang, primary, Welz, A., additional, Pauschinger, M., additional, Fischlein, T., additional, Schächinger, V., additional, Treede, H., additional, Zahn, R., additional, Hennersdorf, M., additional, Albes, J. M., additional, Bekeredjian, R., additional, Beyer, M., additional, Brachmann, J., additional, Butter, C., additional, Bruch, L., additional, Dörge, H., additional, Eichinger, W., additional, Franke, U. F. W., additional, Friedel, N., additional, Giesler, T., additional, Gradaus, R., additional, Hambrecht, R., additional, Haude, M., additional, Hausmann, H., additional, Heintzen, M. P., additional, Jung, W., additional, Kerber, S., additional, Mudra, H., additional, Nordt, T., additional, Pizzulli, L., additional, Sack, F.-U., additional, Sack, S., additional, Schumacher, B., additional, Schymik, G., additional, Sechtem, U., additional, Stellbrink, C., additional, Stumpf, C., additional, and Hoffmeister, H. M., additional

Published
2019
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38. Incidence of new Permanent Pacemaker Implantation after Surgical Aortic Valve Replacement and Transcatheter Aortic Valve Implantation and Its Impact on 1-Year Mortality—Insights from the German Aortic Valve Registry

Author

Fujita, B., additional, Schmidt, T., additional, Bleiziffer, S., additional, Bauer, T., additional, Beckmann, A., additional, Bekeredjian, R., additional, Möllmann, H., additional, Walther, T., additional, Landwehr, S., additional, Hamm, C., additional, Beyersdorf, F., additional, Katus, H., additional, Harringer, W., additional, Ensminger, S., additional, and Frerker, C., additional

Published
2019
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42. Direct Comparison of Rapid Deployment Valves and Conventional Biological Valves for Treatment of Aortic Stenosis: Insights from the German Aortic Valve Registry

Author

Ensminger, S., additional, Fujita, B., additional, Bauer, T., additional, Möllmann, H., additional, Beckmann, A., additional, Bekeredjian, R., additional, Bleiziffer, S., additional, Landwehr, S., additional, Hamm, C., additional, Mohr, F.-W., additional, Katus, H., additional, Harringer, W., additional, Walther, T., additional, and Frerker, C., additional

Published
2018
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43. Conscious Sedation versus General Anesthesia in Transcatheter Aortic Valve Implantation: Insights from the German Aortic Valve Registry

Author

Fujita, B., additional, Husser, O., additional, Hengstenberg, C., additional, Beckmann, A., additional, Möllmann, H., additional, Walther, T., additional, Bekeredjian, R., additional, Bleiziffer, S., additional, Mohr, F.-W., additional, Bauer, T., additional, Ensminger, S., additional, and Frerker, C., additional

Published
2018
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44. Gender-related differences in patients undergoing transcatheter mitral valve interventions: 1-year results from the German TRAMI Registry

Author

Werner, N., Baldus, S., Schillinger, W., Franzen, O., Bekeredjian, R., Sievert, H., Schofer, J., Kuck, K. H., Moellmann, H., Hehrlein, C., Ouarrak, T., Senges, J., Zahn, R., Werner, N., Baldus, S., Schillinger, W., Franzen, O., Bekeredjian, R., Sievert, H., Schofer, J., Kuck, K. H., Moellmann, H., Hehrlein, C., Ouarrak, T., Senges, J., and Zahn, R.

Published
2017

45. The first Scube3 mutant mouse line with pleiotropic phenotypic alterations

Author

Fuchs, H., Sabrautzki, S., Przemeck, G.K.H., Leuchtenberger, S., Lorenz-Depiereux, B., Becker, L., Rathkolb, B., Horsch, M., Garrett, L., Östereicher, M.A., Hans, W., Abe, K., Sagawa, N., Rozman, J., Vargas Panesso, I.L., Sandholzer, M., Lisse, T.S., Adler, T., Aguilar-Pimentel, J.A., Calzada-Wack, J., Ehrhard, N., Elvert, R., Gau, C., Hölter, S.M., Micklich, K., Moreth, K., Prehn, C., Puk, O., Rácz, I., Stöger, C., Vernaleken, A., Michel, D., Diener, S., Wieland, T., Adamski, J., Bekeredjian, R., Lengger, C., Maier, H., Neff, F., Ollert, M., Stöger, T., Yildirim, A.Ö., Strom, T.M., Zimmer, A., Wolf, E., Wurst, W., Klopstock, T., Beckers, J., Gailus-Durner, V., and Hrabě de Angelis, M.

Subjects
SCUBE3, Paget disease of bone (PDB), mouse model, pleiotropy, systemic phenotype
Abstract

The vertebrate Scube (Signal peptide, CUB and EGF-like domain-containing protein) family consists of three independent members Scube1-3, which encode secreted cell surface-associated membrane glycoproteins. Limited information about the general function of this gene family is available, and their roles during adulthood. Here, we present the first Scube3 mutant mouse line (Scube3N294K/N294K) that clearly shows phenotypic alterations by carrying a missense mutation in exon 8, and thus contributes to understand SCUBE3 functions. We performed a detailed phenotypic characterization in the German Mouse Clinic (GMC). Scube3N294K/N294K mutants showed morphological abnormalities of the skeleton, alterations of parameters relevant for bone metabolism, changes in renal function and hearing impairments. These findings correlate with characteristics of the rare metabolic bone disorder Paget disease of bone (PDB), associated with the chromosomal region of human SCUBE3. In addition, alterations in energy metabolism, behavior and neurological functions were detected in Scube3N294K/N294K mice. The Scube3N294K/N294K mutant mouse line may serve as a new model for further studying the effect of impaired SCUBE3 gene function.

Published
2016

46. P6327Prognostic value of pre-procedural 6 minute walk test in patients undergoing MitraClip implantation - insights from the German mitral valve interventions registry

Author

Ledwoch, J., primary, Puls, M., additional, Lubos, E., additional, Boekstegers, P., additional, Von Bardeleben, R.S., additional, Ouarrak, T., additional, Butter, C., additional, Zuern, C., additional, Bekeredjian, R., additional, Nickenig, G., additional, Eggebrecht, H., additional, Senges, J., additional, Schillinger, W., additional, and Sievert, H., additional

Published
2017
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47. 4177Gender-related differences in patients undergoing transcatheter mitral valve interventions: 1-year results from the German TRAMI Registry

Author

Werner, N., primary, Baldus, S., additional, Schillinger, W., additional, Franzen, O., additional, Bekeredjian, R., additional, Sievert, H., additional, Schofer, J., additional, Kuck, K.H., additional, Moellmann, H., additional, Hehrlein, C., additional, Ouarrak, T., additional, Senges, J., additional, and Zahn, R., additional

Published
2017
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48. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Author

Hrabe de Angelis, M. (M), Nicholson, G. (G), Selloum, M. (Mohammed), White, J. (J) K. (K), Morgan, H. (H), Ramirez-Solis, R. (R), Sorg, T. (Tania), Wells, S. (S), Fuchs, H. (H), Fray, M. (M), Adams, D. (D) J. (J), Adams, N. (N) C. (C), Adler, T. (T), Aguilar-Pimentel, A. (A), Ali-Hadji, D. (Dalila), Amann, G. (Grégory), Andre, P. (Philippe), Atkins, S. (S), Auburtin, A. (Aurélie), Ayadi, A. (Abdelkader), Becker, J. (Julien), Becker, L. (L), Bedu, E. (Elodie), Bekeredjian, R. (R), Birling, M. (Marie-Christine), Blake, A. (A), Bottomley, J. (J), Bowl, M. (M) R. (R), Brault, V. (Véronique), Busch, D. (D) H. (H), Bussell, J. (J) N. (N), Calzada-Wack, J. (J), Cater, H. (H), Champy, M. (Marie-France), Charles, P. (Philippe), Chevalier, C. (Claire), Chiani, F. (F), Codner, G. (G) F. (F), Combe, R. (R), Cox, R. (R), Dalloneau, E. (E), Dierich, A. (A), Di Fenza, A. (A), Doe, B. (B), Duchon, A. (Arnaud), Eickelberg, O. (O), Esapa, C. (C) T. (T), Fertak, L. (L) E. (E), Feigel, T. (T), Emelyanova, I. (I), Estabel, J. (J), Favor, J. (J), Flenniken, A. (A), Gambadoro, A. (A), Garrett, L. (L), Gates, H. (H), Gerdin, A. (A) K. (K), Gkoutos, G. (G), Greenaway, S. (S), Glasl, L. (L), Goetz, P. (P), Da Cruz, I. (I) G. (G), Gotz, A. (A), Graw, J. (J), Guimond, A. (Alain), Hans, W. (W), Hicks, G. (G), Holter, S. (S) M. (M), Hofler, H. (H), Hancock, J. (J) M. (M), Hoehndorf, R. (R), Hough, T. (T), Houghton, R. (R), Hurt, A. (A), Ivandic, B. (B), Jacobs, H. (Hugues), Jacquot, S. (Sylvie), Jones, N. (N), Karp, N. (N) A. (A), Katus, H. (H) A. (A), Kitchen, S. (S), Klein-Rodewald, T. (T), Klingenspor, M. (M), Klopstock, T. (T), Lalanne, V. (Valérie), Leblanc, S. (Sophie), Lengger, C. (C), le Marchand, E. (Elise), Ludwig, T. (T), Lux, A. (Aline), McKerlie, C. (C), Maier, H. (H), Mandel, J. (Jean-Louis), Marschall, S. (S), Mark, M. (Manuel), Melvin, D. (D) G. (G), Meziane, H. (Hamid), Micklich, K. (K), Mittelhauser, C. (C), Monassier, L. (Laurent), Moulaert, D. (David), Muller, S. (Stéphanie), Naton, B. (B), Neff, F. (F), Nolan, P. (P) M. (M), Nutter, L. (L) M. (M), Ollert, M. (M), Pavlovic, G. (Guillaume), Pellegata, N. (N) S. (S), Peter, E. (E), Petit-Demouliere, B. (Benoît), Pickard, A. (A), Podrini, C. (C), Potter, P. (P), Pouilly, L. (Laurent), Puk, O. (O), Richardson, D. (D), Rousseau, S. (Stéphane), Quintanilla-Fend, L. (L), Quwailid, M. (M) M. (M), Racz, I. (I), Rathkolb, B. (B), Riet, F. (Fabrice), Rossant, J. (J), Roux, M. (Michel), Rozman, J. (J), Ryder, E. (E), Salisbury, J. (J), Santos, L. (L), Schable, K. (K) H. (H), Schiller, E. (E), Schrewe, A. (A), Schulz, H. (H), Steinkamp, R. (R), Simon, M. (M), Stewart, M. (M), Stoger, C. (C), Stoger, T. (T), Sun, M. (M), Sunter, D. (D), Teboul, L. (L), Tilly, I. (I), Tocchini-Valentini, G. (G) P. (P), Tost, M. (M), Treise, I. (I), Vasseur, L. (Laurent), Velot, E. (E), Vogt-Weisenhorn, D. (D), Wagner, C. (Christel), Walling, A. (A), Wattenhofer-Donze, M. (Marie), Weber, B. (Bruno), Wendling, O. (Olivia), Westerberg, H. (H), Willershauser, M. (M), Wolf, E. (E), Wolter, A. (A), Wood, J. (J), Wurst, W. (W), Yildirim, A. (A) O. (O), Zeh, R. (R), Zimmer, A. (A), Zimprich, A. (A), Consortium, E. (Eumodic), Holmes, C. (C), Steel, K. (K) P. (P), Herault, Y. (Yann), Gailus-Durner, V. (V), Mallon, A. (A) M. (M), and Brown, S. (S) D. (D)

Subjects
Genetics, Male, Mice, Knockout, Heterozygote, Mutant, Homozygote, Aucun, Molecular Sequence Annotation, Biology, Phenotype, Mice, Inbred C57BL, Pleiotropy, ddc:570, Mutation, Animals, Humans, Human genome, Female, Allele, Gene, Gene knockout, Genetic Association Studies
Abstract

The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems. Comment in : Genetic differential calculus. [Nat Genet. 2015] Comment in : Scaling up phenotyping studies. [Nat Biotechnol. 2015]

Published
2015
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49. Optimal implantation depth and adherence to guidelines on permanent pacing to improve the results of transcatheter aortic valve replacement with the Medtronic CoreValve System : the CoreValve Prospective, International, Post-Market ADVANCE-II Study

Author

Petronio, AS, Sinning, JM, van Mieghem, Nicolas, Zucchelli, G, Nickenig, G, Bekeredjian, R, Bosmans, J, Bedogni, F, Branny, M, Stangl, K, Kovac, J, Schiltgen, M, Kraus, S, de Jaegere, Peter, and Cardiology

Subjects
aortic stenosis, conduction disturbance, permanent pacemaker implantation, transcatheter aortic valve replacement, Cardiology and Cardiovascular Medicine, Human medicine
Abstract

OBJECTIVES The aim of the CoreValve prospective, international, post-market ADVANCE-II study was to define the rates of conduction disturbances and permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement with the Medtronic CoreValve System (Minneapolis, Minnesota) using optimized implantation techniques and application of international guidelines on cardiac pacing. BACKGROUND Conduction disturbances are a frequent complication of transcatheter aortic valve replacement. The rates of PPI in the published reports vary according to bioprosthesis type and the indications for PPI. METHODS The primary endpoint was the 30-day incidence of PPI with Class I/II indications when the Medtronic CoreValve System was implanted at an optimal depth (# 6 mm below the aortic annulus). The timing and resolution of all new-onset conduction disturbances were analyzed. RESULTS A total of 194 patients were treated. The overall rate of PPI for Class I/II indications was 18.2%. An optimal depth was reached in 43.2% of patients, with a nonsignificantly lower incidence of PPI in patients with depths # 6 mm, compared with those with deeper implants (13.3% vs. 21.1%; p = 0.14). In a paired analysis, new-onset left bundle branch block and first-degree atrioventricular block occurred in 45.4% and 39.0% of patients, respectively, and resolved spontaneously within 30 days in 43.2% and 73.9%, respectively. In patients with new PPI, the rate of intrinsic sinus rhythm increased from 25.9% at 7 days to 59.3% at 30 days (p = 0.004). CONCLUSIONS Optimal Medtronic CoreValve System deployment and adherence to international guidelines on cardiac pacing are associated with a lower rate of new PPI after transcatheter aortic valve replacement, compared with results reported in previous studies. (CoreValve Advance-II Study: Prospective International Post-Market Study [ADVANCE II]; NCT01624870) ( C) 2015 by the American College of Cardiology Foundation.

Published
2015

50. Transcatheter aortic valve implantation in failed bioprosthetic surgical valves

Author

Dvir, D., Webb, J.G., Bleiziffer, S., Pasic, M., Waksman, R., Kodali, S., Barbanti, M., Latib, A., Schaefer, U., Rodes-Cabau, J., Treede, H., Piazza, N., Hildick-Smith, D., Himbert, D., Walther, T., Hengstenberg, C., Nissen, H., Bekeredjian, R., Presbitero, P., Ferrari, E., Segev, A., Weger, A. de, Windecker, S., Moat, N.E., Napodano, M., Wilbring, M., Cerillo, A.G., Brecker, S., Tchetche, D., Lefevre, T., Marco, F. de, Fiorina, C., Petronio, A.S., Teles, R.C., Testa, L., Laborde, J.C., Leon, M.B., Kornowski, R., Valve In Valve Int Data Registry, and Valve-in-Valve International Data Registry Investigators

Subjects
Aortic valve, Adult, Male, medicine.medical_specialty, Cardiac Catheterization, medicine.medical_treatment, Aortic Valve Insufficiency, Prosthesis Design, Interquartile range, Internal medicine, Aged, Aged, 80 and over, Aortic Valve, Aortic Valve Stenosis, Female, Heart Valve Prosthesis Implantation, Humans, Middle Aged, Prosthesis Failure, Registries, Survival Analysis, Treatment Outcome, Bioprosthesis, Medicine (all), medicine, 80 and over, Survival rate, Survival analysis, Cardiac catheterization, business.industry, Hazard ratio, Aortic Valve/surgery, Aortic Valve Insufficiency/surgery, Aortic Valve Stenosis/surgery, Heart Valve Prosthesis Implantation/methods, General Medicine, medicine.disease, Surgery, Stenosis, medicine.anatomical_structure, Aortic valve stenosis, Cardiology, business
Abstract

IMPORTANCE: Owing to a considerable shift toward bioprosthesis implantation rather than mechanical valves, it is expected that patients will increasingly present with degenerated bioprostheses in the next few years. Transcatheter aortic valve-in-valve implantation is a less invasive approach for patients with structural valve deterioration; however, a comprehensive evaluation of survival after the procedure has not yet been performed. OBJECTIVE: To determine the survival of patients after transcatheter valve-in-valve implantation inside failed surgical bioprosthetic valves. DESIGN, SETTING, AND PARTICIPANTS: Correlates for survival were evaluated using a multinational valve-in-valve registry that included 459 patients with degenerated bioprosthetic valves undergoing valve-in-valve implantation between 2007 and May 2013 in 55 centers (mean age, 77.6 [SD, 9.8] years; 56% men; median Society of Thoracic Surgeons mortality prediction score, 9.8% [interquartile range, 7.7%-16%]). Surgical valves were classified as small (≤21 mm; 29.7%), intermediate (>21 and

Published
2014
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