237 results on '"Bekaert S"'
Search Results
2. Family members’ perspectives of child protection services, a metasynthesis of the literature
- Author
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Bekaert, S., Paavilainen, E., Schecke, H., Baldacchino, A., Jouet, E., Zabłocka – Żytka, L., Bachi, B., Bartoli, F., Carrà, G., Cioni, R.M., Crocamo, C., and Appleton, J.V.
- Published
- 2021
- Full Text
- View/download PDF
3. Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11–CCR3 pathway
- Author
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Bekaert, S., Rocks, N., Vanwinge, C., Noel, A., and Cataldo, D.
- Published
- 2021
- Full Text
- View/download PDF
4. A Pan-European Review of Good Practices in Early Intervention Safeguarding Practice with Children, Young People and Families: Evidence Gathering to Inform a Multi-disciplinary Training Programme (the ERICA Project) in Preventing Child Abuse and Neglect in Seven European Countries
- Author
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Appleton, J, Bekaert, S, Hucker, J, Zlatkute, G, Paavilainen, E, Schecke, H, Specka, M, Scherbaum, N, Jouet, E, Zabłocka-Żytka, L, Woźniak-Prus, M, Czabała, J, Kluczyńska, S, Bachi, B, Bartoli, F, Carrà, G, Cioni, R, Crocamo, C, Rantanen, H, Kaunonen, M, Nieminen, I, Roe, L, Keenan, K, Viganò, G, Baldacchino, A, Appleton, J. V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J. Cz., Kluczyńska, S., Bachi, B., Bartoli, F., Carrà, G., Cioni, R. M., Crocamo, C., Rantanen, H. E., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., Baldacchino, A., Appleton, J, Bekaert, S, Hucker, J, Zlatkute, G, Paavilainen, E, Schecke, H, Specka, M, Scherbaum, N, Jouet, E, Zabłocka-Żytka, L, Woźniak-Prus, M, Czabała, J, Kluczyńska, S, Bachi, B, Bartoli, F, Carrà, G, Cioni, R, Crocamo, C, Rantanen, H, Kaunonen, M, Nieminen, I, Roe, L, Keenan, K, Viganò, G, Baldacchino, A, Appleton, J. V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J. Cz., Kluczyńska, S., Bachi, B., Bartoli, F., Carrà, G., Cioni, R. M., Crocamo, C., Rantanen, H. E., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., and Baldacchino, A.
- Abstract
Child maltreatment has detrimental social and health effects for individuals, families and communities. The ERICA project is a pan-European training programme that equips non-specialist threshold practitioners with knowledge and skills to prevent and detect child maltreatment. This paper describes and presents the findings of a rapid review of good practice examples across seven participating countries including local services, programmes and risk assessment tools used in the detection and prevention of child maltreatment in the family. Learning was applied to the development of the generic training project. A template for mapping the good practice examples was collaboratively developed by the seven participating partner countries. A descriptive data analysis was undertaken organised by an a priori analysis framework. Examples were organised into three areas: programmes tackling child abuse and neglect, local practices in assessment and referral, risk assessment tools. Key findings were identified using a thematic approach. Seventy-two good practice examples were identified and categorised according to area, subcategory and number. A typology was developed as follows: legislative frameworks, child health promotion programmes, national guidance on child maltreatment, local practice guidance, risk assessment tools, local support services, early intervention programmes, telephone or internet-based support services, COVID-19 related good practices. Improved integration of guidance into practice and professional training in child development were highlighted as overarching needs. The impact of COVID-19 on safeguarding issues was apparent. The ERICA training programme formally responded to the learning identified in this international good practice review.
- Published
- 2023
5. A Pan-European Review of Good Practices in Early Intervention Safeguarding Practice with Children, Young People and Families : Evidence Gathering to Inform a Multi-disciplinary Training Programme (the ERICA Project) in Preventing Child Abuse and Neglect in Seven European Countries
- Author
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Appleton, J.V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J., Kluczyńska, S., Bachi, B.F., Bartoli, F., Carrà, G., Cioni, R.M., Crocamo, C., Rantanen, H., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., Baldacchino, A., Tampere University, Health Sciences, Seinäjoen keskussairaala VA, Department of General Administration, Appleton, J, Bekaert, S, Hucker, J, Zlatkute, G, Paavilainen, E, Schecke, H, Specka, M, Scherbaum, N, Jouet, E, Zabłocka-Żytka, L, Woźniak-Prus, M, Czabała, J, Kluczyńska, S, Bachi, B, Bartoli, F, Carrà, G, Cioni, R, Crocamo, C, Rantanen, H, Kaunonen, M, Nieminen, I, Roe, L, Keenan, K, Viganò, G, Baldacchino, A, European Commission, University of St Andrews. School of Medicine, University of St Andrews. Population and Behavioural Science Division, University of St Andrews. School of Geography & Sustainable Development, and University of St Andrews. Centre for Minorities Research (CMR)
- Subjects
Community and Home Care ,MCC ,Multidisciplinary ,SDG 16 - Peace, Justice and Strong Institutions ,3rd-DAS ,European ,3142 Public health care science, environmental and occupational health ,Safeguarding ,3141 Health care science ,HV ,SDG 3 - Good Health and Well-being ,Child protection ,HV Social pathology. Social and public welfare ,Training ,316 Nursing ,Child maltreatment - Abstract
Funding: Funded by the Rights, Equality and Citizenship Programme of the European Commission (European Commission 2019–2021). Child maltreatment has detrimental social and health effects for individuals, families and communities. The ERICA project is a pan-European training programme that equips non-specialist threshold practitioners with knowledge and skills to prevent and detect child maltreatment. This paper describes and presents the findings of a rapid review of good practice examples across seven participating countries including local services, programmes and risk assessment tools used in the detection and prevention of child maltreatment in the family. Learning was applied to the development of the generic training project. A template for mapping the good practice examples was collaboratively developed by the seven participating partner countries. A descriptive data analysis was undertaken organised by an a priori analysis framework. Examples were organised into three areas: programmes tackling child abuse and neglect, local practices in assessment and referral, risk assessment tools. Key findings were identified using a thematic approach. Seventy-two good practice examples were identified and categorised according to area, subcategory and number. A typology was developed as follows: legislative frameworks, child health promotion programmes, national guidance on child maltreatment, local practice guidance, risk assessment tools, local support services, early intervention programmes, telephone or internet-based support services, COVID-19 related good practices. Improved integration of guidance into practice and professional training in child development were highlighted as overarching needs. The impact of COVID-19 on safeguarding issues was apparent. The ERICA training programme formally responded to the learning identified in this international good practice review. Publisher PDF
- Published
- 2023
6. A Pan-European Review of Good Practices in Early Intervention Safeguarding Practice with Children, Young People and Families: Evidence Gathering to Inform a Multi-disciplinary Training Programme (the ERICA Project) in Preventing Child Abuse and Neglect in Seven European Countries
- Author
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Appleton, J. V., primary, Bekaert, S., additional, Hucker, J., additional, Zlatkute, G., additional, Paavilainen, E., additional, Schecke, H., additional, Specka, M., additional, Scherbaum, N., additional, Jouet, E., additional, Zabłocka-Żytka, L., additional, Woźniak-Prus, M., additional, Czabała, J. Cz., additional, Kluczyńska, S., additional, Bachi, B., additional, Bartoli, F., additional, Carrà, G., additional, Cioni, R. M., additional, Crocamo, C., additional, Rantanen, H. E., additional, Kaunonen, M., additional, Nieminen, I., additional, Roe, L., additional, Keenan, K., additional, Viganò, G., additional, and Baldacchino, A., additional
- Published
- 2022
- Full Text
- View/download PDF
7. Family members’ perspectives of child protection services, a metasynthesis of the literature
- Author
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Bekaert, S, Paavilainen, E, Schecke, H, Baldacchino, A, Jouet, E, Zablocka - Zytka, L, Bachi, B, Bartoli, F, Carra, G, Cioni, R, Crocamo, C, Appleton, J, Bekaert S., Paavilainen E., Schecke H., Baldacchino A., Jouet E., Zablocka - Zytka L., Bachi B., Bartoli F., Carra G., Cioni R. M., Crocamo C., Appleton J. V., Bekaert, S, Paavilainen, E, Schecke, H, Baldacchino, A, Jouet, E, Zablocka - Zytka, L, Bachi, B, Bartoli, F, Carra, G, Cioni, R, Crocamo, C, Appleton, J, Bekaert S., Paavilainen E., Schecke H., Baldacchino A., Jouet E., Zablocka - Zytka L., Bachi B., Bartoli F., Carra G., Cioni R. M., Crocamo C., and Appleton J. V.
- Abstract
This metasynthesis brings together what is known about family members’ perspectives of their relationship with social care practitioners as a starting point for developing a pan-European training resource for practitioners. Four databases were searched for qualitative literature with search terms relating to family members and social care practitioners. After the application of inclusion and exclusion criteria, 35 studies were critically appraised and were included in the metasynthesis. Three broad themes were identified through a thematic analysis of the studies’ findings: family members’ perspectives of the system; perceptions of how they were viewed by their worker; and view of their worker. The following aspects are discussed: whether partnership between family and worker is possible within a legal framework; the detrimental effects of cultural bias; and practical foundations for building trust. Recommendations are made for practical support, reflection on cultural practice and broader service provision.
- Published
- 2021
8. A pan-European review of good practices in early intervention safeguarding practice with children, young people and families : evidence gathering to inform a multi-disciplinary training programme (the ERICA project) in preventing child abuse and neglect in seven European countries
- Author
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Appleton, J.V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J., Kluczyńska, S., Bachi, B.F., Bartoli, F., Carrà, G., Cioni, R.M., Crocamo, C., Rantanen, H., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., Baldacchino, A., Appleton, J.V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J., Kluczyńska, S., Bachi, B.F., Bartoli, F., Carrà, G., Cioni, R.M., Crocamo, C., Rantanen, H., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., and Baldacchino, A.
- Published
- 2022
9. Professionals’ Digital Training for Child Maltreatment Prevention in the COVID-19 Era: A Pan-European Model
- Author
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Crocamo, C, Bachi, B, Cioni, R, Schecke, H, Nieminen, I, Zabłocka-Żytka, L, Woźniak-Prus, M, Bartoli, F, Riboldi, I, Appleton, J, Bekaert, S, Zlatkute, G, Jouet, E, Viganò, G, Specka, M, Scherbaum, N, Paavilainen, E, Baldacchino, A, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Cioni, Riccardo M., Schecke, Henrike, Nieminen, Irja, Zabłocka-Żytka, Lidia, Woźniak-Prus, Małgorzata, Bartoli, Francesco, Riboldi, Ilaria, Appleton, Jane V., Bekaert, Sarah, Zlatkute, Giedre, Jouet, Emmanuelle, Viganò, Giovanni, Specka, Michael, Scherbaum, Norbert, Paavilainen, Eija, Baldacchino, Alexander, Carrà, Giuseppe, Crocamo, C, Bachi, B, Cioni, R, Schecke, H, Nieminen, I, Zabłocka-Żytka, L, Woźniak-Prus, M, Bartoli, F, Riboldi, I, Appleton, J, Bekaert, S, Zlatkute, G, Jouet, E, Viganò, G, Specka, M, Scherbaum, N, Paavilainen, E, Baldacchino, A, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Cioni, Riccardo M., Schecke, Henrike, Nieminen, Irja, Zabłocka-Żytka, Lidia, Woźniak-Prus, Małgorzata, Bartoli, Francesco, Riboldi, Ilaria, Appleton, Jane V., Bekaert, Sarah, Zlatkute, Giedre, Jouet, Emmanuelle, Viganò, Giovanni, Specka, Michael, Scherbaum, Norbert, Paavilainen, Eija, Baldacchino, Alexander, and Carrà, Giuseppe
- Abstract
The responsiveness of professionals working with children and families is of key importance for child maltreatment early identification. However, this might be undermined when multifaceted circumstances, such as the COVID-19 pandemic, reduce interdisciplinary educational activities. Thanks to technological developments, digital platforms seem promising in dealing with new challenges for professionals’ training. We examined a digital approach to child maltreatment training through the ERICA project experience (Stopping Child Maltreatment through Pan-European Multiprofessional Training Programme). ERICA has been piloted during the pandemic in seven European centers involving interconnected sectors of professionals working with children and families. The training consisted of interactive modules embedded in a digital learning framework. Different aspects (technology, interaction, and organization) were evaluated and trainers’ feedback on digital features was sought. Technical issues were the main barrier, however, these did not significantly disrupt the training. The trainers perceived reduced interaction between participants, although distinct factors were uncovered as potential favorable mediators. Based on participants’ subjective experiences and perspectives, digital learning frameworks for professionals working with children and families (such as the ERICA model nested in its indispensable adaptation to an e-learning mode) can represent a novel interactive approach to empower trainers and trainees to tackle child maltreatment during critical times such as a pandemic, and as an alternative to more traditional learning frameworks.
- Published
- 2022
10. Corrigendum to “Clinical Behavior of Second-Generation Zirconia Monolithic Posterior Restorations: Two-year Results of a Prospective Study with Ex Vivo Analyses including Patients with Clinical Signs of Bruxism” [J. Dent. 91 (2019) 103229]
- Author
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Koenig, V., primary, Wulfman, C., additional, Bekaert, S., additional, Dupont, N., additional, Le Goff, S., additional, Eldafrawy, M., additional, Vanheusden, A., additional, and Mainjot, A., additional
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- 2021
- Full Text
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11. Intraoral low-temperature degradation of monolithic zirconia dental prostheses: Results of a prospective clinical study with ex vivo monitoring
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Koenig, V., primary, Bekaert, S., additional, Dupont, N., additional, Vanheusden, A., additional, Le Goff, S., additional, Douillard, T., additional, Chevalier, J., additional, Djaker, N., additional, Lamy de la Chapelle, M., additional, Amiard, F., additional, Dardenne, N., additional, Wulfman, C., additional, and Mainjot, A., additional
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- 2021
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12. Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men
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Ruige, J. B., Rietzschel, E. R., De Buyzere, M. L., Bekaert, S., Segers, P., De Bacquer, D., De Backer, G., Gillebert, T. C, and Kaufman, J. M.
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- 2011
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13. The one-step no-prep approach for full-mouth rehabilitation of worn dentition using PICN CAD-CAM restorations: 2-yr results of a prospective clinical study
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Oudkerk, J, primary, Eldafrawy, M, additional, Bekaert, S, additional, Grenade, C, additional, Vanheusden, A, additional, and Mainjot, A, additional
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- 2020
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14. Clinical behavior of second-generation zirconia monolithic posterior restorations: Two-year results of a prospective study with Ex vivo analyses including patients with clinical signs of bruxism
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Koenig, V., primary, Wulfman, C., additional, Bekaert, S., additional, Dupont, N., additional, Le Goff, S., additional, Eldafrawy, M., additional, Vanheusden, A., additional, and Mainjot, A., additional
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- 2019
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15. E2Fs mediate a fundamental cell-cycle deregulation in high-grade serous ovarian carcinomas
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De Meyer, T, Bijsmans, ITGW, Van de Vijver, KK, Bekaert, S, Oosting, J, Van Criekinge, W, van Engeland, M, and Sieben, NLG
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- 2009
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16. Telomere biology in giant cell tumour of bone#
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Forsyth, R G, De Boeck, G, Bekaert, S, De Meyer, T, Taminiau, A HM, Uyttendaele, D, Roels, H, Praet, M M, and Hogendoorn, P CW
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- 2008
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17. Reversal of cold induced haemoconcentration
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Vogelaere, P., Savourey, G., Deklunder, G., Lecroart, J., Brasseur, M., Bekaert, S., and Bittel, J.
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- 1992
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18. Hematological variations at rest and during maximal and submaximal exercise in a cold (0°C) environment
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Vogelaere, P., Brasseur, M., Quirion, A., Leclercq, R., Laurencelle, L., and Bekaert, S.
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- 1990
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19. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
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Wain, Louise V., Verwoert, Germaine C., O'Reilly, Paul F., Shi, Gang, Johnson, Toby, Johnson, Andrew D., Bochud, Murielle, Rice, Kenneth M., Henneman, Peter, Smith, Albert V., Ehret, Georg B., Amin, Najaf, Larson, Martin G., Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile J. W., Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'An, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U., Webster, Rebecca J., Zhang, Feng, Peden, John F., Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I., Trompet, Stella, Bragg-Gresham, Jennifer L., Alizadeh, Behrooz Z., Chambers, John C., Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M., Polašek, Ozren, Boban, Mladen, Nelson, Christopher P., Morrison, Alanna C., Pihur, Vasyl, Ganesh, Santhi K., Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco U. S., Rivadeneira, Fernando, Sijbrands, Eric J. G., Uitterlinden, Andre G., Hwang, Shih-Jen, Vasan, Ramachandran S., Wang, Thomas J., Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L., Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Glazer, Nicole L., Taylor, Kent D., Harris, Tamara B., Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, In S., Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M., Penninx, Brenda W., Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco M, Fabiola, Facheris, Maurizio, Collins, Francis S., Bergman, Richard N., Beilby, John P., Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S., Navarro, Pau, Wild, Sarah H., Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco J. C., Willemsen, Gonneke, Parker, Alex N., Rose, Lynda M., Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, Van Der Klauw, Melanie M., Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M., Emilsson, Valur, Plump, Andrew, Lindeman, Jan H., Hoen, Peter A. C. T., König, Inke R., Felix, Janine F., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L., Fornage, Myriam, Mitchell, Gary F., Smith, Nicholas L., Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Samani, Nilesh J., Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J., Wichmann, H-Erich, Raitakari, Olli T., Palmas, Walter, Kooner, Jaspal S., Stolk, Ronald P., Jukema, J Wouter, Wright, Alan F., Boomsma, Dorret I., Bandinelli, Stefania, Gyllensten, Ulf B., Wilson, James F., Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D., Palmer, Lyle J., Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth J. F., Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J., Oostra, Ben A., Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P., Beckmann, Jacques S., Witteman, Jacqueline C. M., Erdmann, Jeanette, Van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M., Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R., Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B., Psaty, Bruce M., Caulfield, Mark J., Rao, Dabeeru C., Tobin, Martin D., Elliott, Paul, Van Duijn, Cornelia M. McEniery CM, Wilkinson IB, Cockcroft JR, O'Shaughnessy KM, Newhouse SJ, Yasmin, Smith AV, Eiriksdottir G, Launer LJ, Sigurdsson S, Aspelund T, Gudnason V, De Bacquer D, Rietzschel ER, De Backer GG, Van Bortel L, De Buyzere ML, Segers P, Bekaert S, Gillebert TC, De Meyer T, Ferrucci L, Tanaka T, Johnson AD, Levy D, Benjamin EJ, Mitchell GF, Vita JA, Larson MG, Hamburg NM, Vasan RS, Isaacs A, Schut AF, Oostra BA, van Duijn CM, van Rijn MJ, Sie MP, Newman AB, Herrington DM, Andrews JS, Ding J, Sutton-Tyrrell KC, Harris TB, Howard TD, Liu Y, Parsa A, Shuldiner AR, McArdle PF, Gibson Q, Post WS, Dehghan A, Hofman A, Uitterlinden AG, Sijbrands EJ, Rivadeneira F, Mattace-Raso FU, Verwoert GC, Witteman JC, Scuteri A, Lakatta EG, Jewell E, Abecasis GR, Tarasov KV, Uda M, Najjar SS, Sanna S, Attwood T, Belz S, Braund P, Cambien F, Cooper J, Crisp-Hihn A, Deloukas P, Foad N, Eardman J, Goodall AH, Gracey J, Gray E, Gulde S, Gwilliams R, Heimerl S, Hengstenberg C, Jolley J, Krishnan U, Linsel-Nitschke P, Lloyd-Jones H, Lugauer I, Lundmark P, Maouche S, Moore JS, Muir D, Murray E, Nelson CP, Neudert J, Niblett D, O'Leary K, Ouwehand WH, Pollard H, Rankin A, Rice CM, Sager H, Samani NJ, Sambrook J, Schmitz G, Scholz M, Schroeder L, Schunkert H, Syvannen AC, Wallace C, Kathiresan S, Reilly MP, Erdmann J, Assimes TL, Boerwinkle E, Hall A, König IR, Laaksonen R, McPherson R, Thompson JR, Thorsteinsdottir U, Ziegler A, Absher D, Chen L, Cupples LA, Halperin E, Li M, Musunuru K, Preuss M, Schillert A, Thorleifsson G, Voight BF, Wells GA, Assime TL, Holm H, Roberts R, Stewart AF, Fortmann S, Go A, Hlatky M, Iribarren C, Knowles J, Myers R, Quertermous T, Sidney S, Risch N, Tang H, Blankenberg S, Zeller T, Wild P, Schnabel R, Sinning C, Lackner K, Tiret L, Nicaud V, Bickel C, Rupprecht HJ, Perret C, Proust C, Münzel T, Barbalic M, Bis J, Chen IY, Cupples L, Demissie-Banjaw S, Folsom A, Glazer N, Harris T, Heckbert S, Lumley T, Marciante K, Morrison A, O' Donnell CJ, Psaty BM, Rice K, Rotter JI, Siscovick DS, Smith N, Smith A, Taylor KD, van Duijn C, Volcik K, Whitteman J, Ramachandran V, Uitterlinden A, Gretarsdottir S, Gulcher JR, Kong A, Stefansson K, Thorgeirsson G, Andersen K, Fischer M, Grosshennig A, Lieb W, Stark K, Schreiber S, Wichmann HE, Aherrahrou Z, Bruse P, Doering A, Illig T, Klopp N, Loley C, Medack A, Meisinger C, Meitinger T, Nahrstedt J, Peters A, Wagner AK, Willenborg C, Böhm BO, Dobnig H, Grammer TB, Hoffmann MM, Kleber M, März W, Meinitzer A, Winkelmann BR, Pilz S, Renner W, Scharnagl H, Stojakovic T, Tomaschitz A, Winkler K, Guiducci C, Burtt N, Gabriel SB, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Dandona S, Jarinova O, Qu L, Wilensky R, Matthai W, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser V, Epstein SE, Rader DJ, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall AS, Smith NL, Felix JF, Morrison AC, Demissie S, Glazer NL, Loehr LR, Rosamond WD, Bis JC, Folsom AR, Benjamin E, Aulchenko YS, Haritunians T, Couper D, Murabito J, Yang YA, Stricker BH, Gottdiener JS, Chang PP, Wang TJ, Rice KM, Heckbert SR, Fox ER, Willerson JT, Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Gao X, Yang Q, O'Connell JR, Schmidt H, Ketkar S, Hwang SJ, Teumer A, Paré G, Atkinson EJ, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Rampersaud E, Mitchell BD, Arking DE, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Siscovick D, Zillikens MC, Feitosa M, Province M, de Andrade M, Turner ST, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Coresh J, Schmidt R, Shlipak MG, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS, Felix SB, Watzinger N, Homuth G, Aragam J, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Deckers JW, Stritzke J, Lackner KJ, Ingelsson E, Kullo I, Haerting J, Reffelmann T, Redfield MM, Werdan K, Arnett DK, Blettner M, Friedrich N, Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ, Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Munroe PB, Nordfors L, Penninx BW, Perucha E, Pouta A, Roderick PJ, Ruokonen A, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Ubink-Veltmaat LJ, Vollenweider P, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS., Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), University of Leicester, Department of Genetics [Leicester], Erasmus University Rotterdam, Netherlands Genomics Initiative, Department of Epidemiology and Biostatistics, School of Public Health, Zahedan University of Medical Sciences, Washington University in Saint Louis (WUSTL), Queen Mary University of London (QMUL), National Heart, Lung and Blood Institute, Partenaires INRAE, Centre Hospitalier Universitaire Vaudois (CHUV), Université de Lausanne = University of Lausanne (UNIL), Department of Biostatistics [Oslo], Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Leiden University Medical Center (LUMC), Universiteit Leiden, Icelandic Heart Association, Heart Preventive Clinic and Research Institute, University of Iceland [Reykjavik], Johns Hopkins University, School of Medicine, Hôpitaux Universitaires de Genève (HUG), Department of Epidemiology, The Netherlands Cancer Institute, Department of Mathematics, Boston University [Boston] (BU), GlaxoSmithKline, Division of Community Health Sciences, St. George's, University of South Florida [Tampa] (USF), Universität Greifswald - University of Greifswald, University of Washington [Seattle], University of 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population Health Sciences, University of Edinburgh, Uppsala University, Vrije Universiteit Amsterdam [Amsterdam] (VU), Western General Hospital, Harvard Medical School [Boston] (HMS), Brigham and Women's Hospital [Boston], University of Michigan System, University of Groningen, Ealing Hospital, School of Public Health - Department of Epidemiology and Biostatistics, Imperial College London, Medical Genetics Institute, Cedars-Sinai Medical Center, University of Tampere, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Split, The University of Texas Health Science Center at Houston (UTHealth), Johns Hopkins University (JHU), Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), Swiss Institute of Bioinformatics [Lausanne] (SIB), Finnish Institute of Occupational Health, National Institute of Health and Welfare, University of Oulu, Lapland Central Hospital, University of Bristol [Bristol], Institute for Community Medicine, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), US National Institutes of Health, National Heart, Lung, and Blood Institute, European, Epidemiology, Internal Medicine, Public Health, Clinical Genetics, Université de Lausanne (UNIL), LeidenUniversity Medical Centre, University of Iceland, Università degli studi di Trieste, Universität zu Lübeck [Lübeck], University of Western Australia, University of Oxford [Oxford], VU University Amsterdam, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Human genetics, Psychiatry, EMGO - Mental health, NCA - Anxiety & Depression, Epidemiology and Data Science, Medical Research Council (MRC), Louise V., Wain, Germaine C., Verwoert, Paul F., O'Reilly, Gang, Shi, Toby, Johnson, Andrew D., Johnson, Murielle, Bochud, Kenneth M., Rice, Peter, Henneman, Albert V., Smith, Georg B., Ehret, Najaf, Amin, Martin G., Larson, Vincent, Mooser, David, Hadley, Marcus, Dörr, Joshua C., Bi, Thor, Aspelund, Tõnu, Esko, A. Cecile J. W., Janssen, Jing Hua, Zhao, Simon, Heath, Maris, Laan, Jingyuan, Fu, Giorgio, Pisti, Jian'An, Luan, Pankaj, Arora, Gavin, Luca, Pirastu, Nicola, Irene, Pichler, Anne U., Jackson, Rebecca J., Webster, Feng, Zhang, John F., Peden, Helena, Schmidt, Toshiko, Tanaka, Harry, Campbell, Wilmar, Igl, Yuri, Milaneschi, Jouke Jan, Hottenga, Veronique, Vitart, Daniel I., Chasman, Stella, Trompet, Jennifer L., Bragg Gresham, Behrooz Z., Alizadeh, John C., Chamber, Xiuqing, Guo, Terho, Lehtimäki, Brigitte, Kühnel, Lorna M., Lopez, Ozren, Polašek, Mladen, Boban, Christopher P., Nelson, Alanna C., Morrison, Vasyl, Pihur, Santhi K., Ganesh, Albert, Hofman, Suman, Kundu, Francesco U. S., Mattace Raso, Fernando, Rivadeneira, Eric J. G., Sijbrand, Andre G., Uitterlinden, Shih Jen, Hwang, Ramachandran S., Vasan, Thomas J., Wang, Sven, Bergmann, Peter, Vollenweider, Gérard, Waeber, Jaana, Laitinen, Anneli, Pouta, Paavo, Zitting, Wendy L., Mcardle, Heyo K., Kroemer, Uwe, Völker, Henry, Völzke, Nicole L., Glazer, Kent D., Taylor, Tamara B., Harri, Helene, Alavere, Toomas, Haller, Aime, Kei, Mari Liis, Tammesoo, Yurii, Aulchenko, Inês, Barroso, Kay Tee, Khaw, Pilar, Galan, Serge, Hercberg, Mark, Lathrop, Susana, Eyheramendy, Elin, Org, Siim, Sõber, Xiaowen, Lu, Ilja M., Nolte, Brenda W., Penninx, Tanguy, Corre, Corrado, Masciullo, Cinzia, Sala, Leif, Groop, Benjamin F., Voight, Olle, Melander, Christopher J., O'Donnell, Veikko, Salomaa, D'Adamo, ADAMO PIO, Antonella, Fabretto, Flavio, Faletra, Sheila, Ulivi, Fabiola Del Greco, M, Maurizio, Facheri, Francis S., Collin, Richard N., Bergman, John P., Beilby, Joseph, Hung, A., William Musk, Massimo, Mangino, So Youn, Shin, Nicole, Soranzo, Hugh, Watkin, Anuj, Goel, Anders, Hamsten, Pierre, Gider, Marisa, Loitfelder, Marion, Zeginigg, Dena, Hernandez, Samer S., Najjar, Pau, Navarro, Sarah H., Wild, Anna Maria, Corsi, Andrew, Singleton, Eco J. C., de Geu, Gonneke, Willemsen, Alex N., Parker, Lynda M., Rose, Brendan, Buckley, David, Stott, Marco, Orru, Manuela, Uda, Melanie M., van der Klauw, Weihua, Zhang, Xinzhong, Li, James, Scott, Yii Der Ida, Chen, Gregory L., Burke, Mika, Kähönen, Jorma, Viikari, Angela, Döring, Thomas, Meitinger, Gail, Davie, John M., Starr, Valur, Emilsson, Andrew, Plump, Jan H., Lindeman, Peter A. C., 't Hoen, Inke R., König, Janine F., Felix, Robert, Clarke, Jemma C., Hopewell, Halit, Ongen, Monique, Breteler, Stéphanie, Debette, Anita L., Destefano, Myriam, Fornage, Gary F., Mitchell, Nicholas L., Smith, Hilma, Holm, Kari, Stefansson, Gudmar, Thorleifsson, Unnur, Thorsteinsdottir, Nilesh J., Samani, Michael, Preu, Igor, Rudan, Caroline, Hayward, Ian J., Deary, H., Erich Wichmann, Olli T., Raitakari, Walter, Palma, Jaspal S., Kooner, Ronald P., Stolk, J., Wouter Jukema, Alan F., Wright, Dorret I., Boomsma, Stefania, Bandinelli, Ulf B., Gyllensten, James F., Wilson, Luigi, Ferrucci, Reinhold, Schmidt, Martin, Farrall, Tim D., Spector, Lyle J., Palmer, Jaakko, Tuomilehto, Arne, Pfeufer, Gasparini, Paolo, David, Siscovick, David, Altshuler, Ruth J. F., Loo, Daniela, Toniolo, Harold, Snieder, Christian, Gieger, Pierre, Meneton, Nicholas J., Wareham, Ben A., Oostra, Andres, Metspalu, Lenore, Launer, Rainer, Rettig, David P., Strachan, Jacques S., Beckmann, Jacqueline C. M., Witteman, Jeanette, Erdmann, Ko Willems van, Dijk, Eric, Boerwinkle, Michael, Boehnke, Paul M., Ridker, Marjo Riitta, Jarvelin, Aravinda, Chakravarti, Goncalo R., Abecasi, Vilmundur, Gudnason, Christopher Newton, Cheh, Daniel, Levy, Patricia B., Munroe, Bruce M., Psaty, Mark J., Caulfield, Dabeeru C., Rao, Martin D., Tobin, Paul, Elliott, Cornelia M., van Duijn, Biological Psychology, Neuroscience Campus Amsterdam - Anxiety & Depression, EMGO+ - Mental Health, Wain, Louise V., Verwoert, Germaine C., O'Reilly, Paul F., Shi, Gang, Johnson, Toby, Johnson, Andrew D., Bochud, Murielle, Rice, Kenneth M., Henneman, Peter, Smith, Albert V., Ehret, Georg B., Amin, Najaf, Larson, Martin G., Mooser, Vincent, Hadley, David, Dörr, Marcu, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile J. W., Zhao, Jing Hua, Heath, Simon, Laan, Mari, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'An, Arora, Pankaj, Lucas, Gavin, Pichler, Irene, Jackson, Anne U., Webster, Rebecca J., Zhang, Feng, Peden, John F., Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I., Trompet, Stella, Bragg-Gresham, Jennifer L., Alizadeh, Behrooz Z., Chambers, John C., Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M., Polašek, Ozren, Boban, Mladen, Nelson, Christopher P., Morrison, Alanna C., Pihur, Vasyl, Ganesh, Santhi K., Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco U. S., Rivadeneira, Fernando, Sijbrands, Eric J. G., Uitterlinden, Andre G., Hwang, Shih-Jen, Vasan, Ramachandran S., Wang, Thomas J., Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, Mcardle, Wendy L., Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Glazer, Nicole L., Taylor, Kent D., Harris, Tamara B., Alavere, Helene, Haller, Tooma, Keis, Aime, Tammesoo, Mari-Lii, Aulchenko, Yurii, Barroso, In S., Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M., Penninx, Brenda W., Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco M, Fabiola, Facheris, Maurizio, Collins, Francis S., Bergman, Richard N., Beilby, John P., Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Ander, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S., Navarro, Pau, Wild, Sarah H., Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco J. C., Willemsen, Gonneke, Parker, Alex N., Rose, Lynda M., Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, Van Der Klauw, Melanie M., Zhang, Weihua, Li, Xinzhong, Scott, Jame, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thoma, Davies, Gail, Starr, John M., Emilsson, Valur, Plump, Andrew, Lindeman, Jan H., Hoen, Peter A. C. T., König, Inke R., Felix, Janine F., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L., Fornage, Myriam, Mitchell, Gary F., Smith, Nicholas L., Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Samani, Nilesh J., Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J., Wichmann, H-Erich, Raitakari, Olli T., Palmas, Walter, Kooner, Jaspal S., Stolk, Ronald P., Jukema, J Wouter, Wright, Alan F., Boomsma, Dorret I., Bandinelli, Stefania, Gyllensten, Ulf B., Wilson, James F., Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D., Palmer, Lyle J., Tuomilehto, Jaakko, Pfeufer, Arne, Siscovick, David, Altshuler, David, Loos, Ruth J. F., Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J., Oostra, Ben A., Metspalu, Andre, Launer, Lenore, Rettig, Rainer, Strachan, David P., Beckmann, Jacques S., Witteman, Jacqueline C. M., Erdmann, Jeanette, Van Dijk, Ko Willem, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M., Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R., Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B., Psaty, Bruce M., Caulfield, Mark J., Rao, Dabeeru C., Tobin, Martin D., Elliott, Paul, Van, Duijn, Cornelia M., McEniery CM, Wilkinson, Ib, Cockcroft, Jr, O'Shaughnessy, Km, Newhouse, Sj, Yasmin, Smith, Av, Eiriksdottir, G, Launer, Lj, Sigurdsson, S, Aspelund, T, Gudnason, V, De Bacquer, D, Rietzschel, Er, De Backer, Gg, Van Bortel, L, De Buyzere, Ml, Segers, P, Bekaert, S, Gillebert, Tc, De Meyer, T, Ferrucci, L, Tanaka, T, Johnson, Ad, Levy, D, Benjamin, Ej, Mitchell, Gf, Vita, Ja, Larson, Mg, Hamburg, Nm, Vasan, R, Isaacs, A, Schut, Af, Oostra, Ba, van Duijn, Cm, van Rijn, Mj, Sie, Mp, Newman, Ab, Herrington, Dm, Andrews, J, Ding, J, Sutton-Tyrrell, Kc, Harris, Tb, Howard, Td, Liu, Y, Parsa, A, Shuldiner, Ar, Mcardle, Pf, Gibson, Q, Post, W, Dehghan, A, Hofman, A, Uitterlinden, Ag, Sijbrands, Ej, Rivadeneira, F, Mattace-Raso, Fu, Verwoert, Gc, Witteman, Jc, Scuteri, A, Lakatta, Eg, Jewell, E, Abecasis, Gr, Tarasov, Kv, Uda, M, Najjar, S, Sanna, S, Attwood, T, Belz, S, Braund, P, Cambien, F, Cooper, J, Crisp-Hihn, A, Deloukas, P, Foad, N, Eardman, J, Goodall, Ah, Gracey, J, Gray, E, Gulde, S, Gwilliams, R, Heimerl, S, Hengstenberg, C, Jolley, J, Krishnan, U, Linsel-Nitschke, P, Lloyd-Jones, H, Lugauer, I, Lundmark, P, Maouche, S, Moore, J, Muir, D, Murray, E, Nelson, Cp, Neudert, J, Niblett, D, O'Leary, K, Ouwehand, Wh, Pollard, H, Rankin, A, Rice, Cm, Sager, H, Samani, Nj, Sambrook, J, Schmitz, G, Scholz, M, Schroeder, L, Schunkert, H, Syvannen, Ac, Wallace, C, Kathiresan, S, Reilly, Mp, Erdmann, J, Assimes, Tl, Boerwinkle, E, Hall, A, König, Ir, Laaksonen, R, Mcpherson, R, Thompson, Jr, Thorsteinsdottir, U, Ziegler, A, Absher, D, Chen, L, Cupples, La, Halperin, E, Li, M, Musunuru, K, Preuss, M, Schillert, A, Thorleifsson, G, Voight, Bf, Wells, Ga, Assime, Tl, Holm, H, Roberts, R, Stewart, Af, Fortmann, S, Go, A, Hlatky, M, Iribarren, C, Knowles, J, Myers, R, Quertermous, T, Sidney, S, Risch, N, Tang, H, Blankenberg, S, Zeller, T, Wild, P, Schnabel, R, Sinning, C, Lackner, K, Tiret, L, Nicaud, V, Bickel, C, Rupprecht, Hj, Perret, C, Proust, C, Münzel, T, Barbalic, M, Bis, J, Chen, Iy, Cupples, L, Demissie-Banjaw, S, Folsom, A, Glazer, N, Harris, T, Heckbert, S, Lumley, T, Marciante, K, Morrison, A, O' Donnell, Cj, Psaty, Bm, Rice, K, Rotter, Ji, Siscovick, D, Smith, N, Smith, A, Taylor, Kd, van Duijn, C, Volcik, K, Whitteman, J, Ramachandran, V, Uitterlinden, A, Gretarsdottir, S, Gulcher, Jr, Kong, A, Stefansson, K, Thorgeirsson, G, Andersen, K, Fischer, M, Grosshennig, A, Lieb, W, Stark, K, Schreiber, S, Wichmann, He, Aherrahrou, Z, Bruse, P, Doering, A, Illig, T, Klopp, N, Loley, C, Medack, A, Meisinger, C, Meitinger, T, Nahrstedt, J, Peters, A, Wagner, Ak, Willenborg, C, Böhm, Bo, Dobnig, H, Grammer, Tb, Hoffmann, Mm, Kleber, M, März, W, Meinitzer, A, Winkelmann, Br, Pilz, S, Renner, W, Scharnagl, H, Stojakovic, T, Tomaschitz, A, Winkler, K, Guiducci, C, Burtt, N, Gabriel, Sb, O'Donnell, Cj, Elosua, R, Peltonen, L, Salomaa, V, Schwartz, Sm, Melander, O, Altshuler, D, Dandona, S, Jarinova, O, Qu, L, Wilensky, R, Matthai, W, Hakonarson, Hh, Devaney, J, Burnett, M, Pichard, Ad, Kent, Km, Satler, L, Lindsay, Jm, Waksman, R, Knouff, Cw, Waterworth, Dm, Walker, Mc, Mooser, V, Epstein, Se, Rader, Dj, Wright, Bj, Balmforth, Aj, Ball, Sg, Smith, Nl, Felix, Jf, Morrison, Ac, Demissie, S, Glazer, Nl, Loehr, Lr, Rosamond, Wd, Bis, Jc, Folsom, Ar, Benjamin, E, Aulchenko, Y, Haritunians, T, Couper, D, Murabito, J, Yang, Ya, Stricker, Bh, Gottdiener, J, Chang, Pp, Wang, Tj, Rice, Km, Heckbert, Sr, Fox, Er, Willerson, Jt, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Gao, X, Yang, Q, O'Connell, Jr, Schmidt, H, Ketkar, S, Hwang, Sj, Teumer, A, Paré, G, Atkinson, Ej, Lohman, K, Cornelis, Mc, Probst-Hensch, Nm, Kronenberg, F, Tönjes, A, Hayward, C, Rampersaud, E, Mitchell, Bd, Arking, De, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer, Ih, Zillikens, Mc, Feitosa, M, Province, M, de Andrade, M, Turner, St, Schnabel, Rb, Wilde, S, Munzel, Tf, Leak, T, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, Fb, Johansson, A, Igl, W, Zaboli, G, Wild, Sh, Wright, Af, Campbell, H, Ellinghaus, D, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, Hk, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, An, Ridker, Pm, Kardia, Sl, Curhan, Gc, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Coresh, J, Schmidt, R, Shlipak, Mg, Borecki, I, Krämer, Bk, Rudan, I, Gyllensten, U, Wilson, Jf, Pramstaller, Pp, Rettig, R, Hastie, N, Chasman, Di, Kao, Wh, Heid, Im, Fox, C, Felix, Sb, Watzinger, N, Homuth, G, Aragam, J, Dörr, M, Zweiker, R, Lind, L, Rodeheffer, Rj, Greiser, Kh, Deckers, Jw, Stritzke, J, Lackner, Kj, Ingelsson, E, Kullo, I, Haerting, J, Reffelmann, T, Redfield, Mm, Werdan, K, Arnett, Dk, Blettner, M, Friedrich, N, Chambers, Jc, Zhang, W, Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, J, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Davey Smith, G, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, Homan van der Heide, Jj, Hepkema, Bg, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, de Jong, Pe, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Munroe, Pb, Nordfors, L, Penninx, Bw, Perucha, E, Pouta, A, Roderick, Pj, Ruokonen, A, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Ubink-Veltmaat, Lj, Vollenweider, P, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Lightstone, L, Scott, J, Navis, G, Elliott, P, and Kooner, Js.
- Subjects
Netherlands Twin Register (NTR) ,Linkage disequilibrium ,pulse pressure ,mean arterial pressure ,genome-wide ,[SDV]Life Sciences [q-bio] ,Genome-wide association study ,BLOOD-PRESSURE ,Blood Pressure ,030204 cardiovascular system & hematology ,Linkage Disequilibrium ,0302 clinical medicine ,RELEVANCE ,CardioGram ,Medicine and Health Sciences ,Genetics & Heredity ,ddc:616 ,Genetics ,0303 health sciences ,Genome-wide association ,11 Medical And Health Sciences ,Arteries ,ADRENERGIC-RECEPTOR TRAFFICKING ,Pulse pressure ,EchoGen consortium ,Hypertension ,HEART-FAILURE ,arterial pressure ,Case-Control Studie ,Life Sciences & Biomedicine ,Human ,circulatory and respiratory physiology ,medicine.medical_specialty ,Mean arterial pressure ,Arterie ,AortaGen Consortium ,Cardiogenics consortium ,Locus (genetics) ,Biology ,Polymorphism, Single Nucleotide ,Article ,Follow-Up Studie ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,METAANALYSIS ,030304 developmental biology ,Genetic association ,Science & Technology ,HYPERTENSION ,MORTALITY ,Case-control study ,CARDIOVASCULAR-DISEASE RISK ,06 Biological Sciences ,GENE ,MICE ,Endocrinology ,Blood pressure ,CKDGen consortium ,Genetic Loci ,Case-Control Studies ,KidneyGen consortium ,CHARGE Consortium Heart Failure Working Group ,LifeLines Cohort Study ,Developmental Biology ,Follow-Up Studies ,Genome-Wide Association Study - Abstract
Les affiliations des 100 premiers auteurs sont renseignées dans la notice. Les affiliations des autres auteurs sont disponibles à la fin de la publication.; International audience; Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
- Published
- 2016
20. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
- Author
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Teumer, A. (Alexander), Chaker, L. (Layal), Groeneweg, S. (Stefan), Li, Y. (Yong), Di Munno, C. (Celia), Barbieri, C. (Caterina), Schultheiss, U.T. (Ulla T.), Traglia, M. (Michela), Ahluwalia, T.S. (Tarunveer Singh), Akiyama, M. (Masato), Appel, E.V.R. (Emil Vincent R.), Arking, D.E. (Dan), Arnold, A.M. (Alice), Astrup, A. (Arne), Beekman, M. (Marian), Beilby, J.P. (John), Bekaert, S. (Sofie), Boerwinkle, E. (Eric), Brown, S.J. (Stephen), Buyzere, M. (Marc) de, Campbell, P.J. (Purdey J.), Ceresini, G. (Graziano), Cerqueira, C. (Charlotte), Cucca, F. (Francesco), Deary, I.J. (Ian), Deelen, J. (Joris), Eckardt, K.-U. (Kai-Uwe), Ekici, A.B. (Arif B.), Hagen, K. (Knut), Ferrrucci, L. (Luigi), Fiers, T. (Tom), Fiorillo, E. (Edoardo), Ford, I. (Ian), Fox, C.S. (Caroline), Fuchsberger, C. (Christian), Galesloot, T.E. (Tessel), Gieger, C. (Christian), Gögele, M. (Martin), Grandi, A. (Alessandro) de, Grarup, N. (Niels), Greiser, K.H. (Karin Halina), Haljas, K. (Kadri), Hansen, T. (Torben), Harris, S.E. (Sarah), Heemst, D. (Diana) van, Heijer, M. (Martin) den, Hicks, A.A. (Andrew A.), Hollander, W. (Wouter) den, Homuth, G. (Georg), Hui, J. (Jennie), Ikram, M.A. (Arfan), Ittermann, T. (Till), Jensen, R.A. (Richard A.), Jing, J. (Jiaojiao), Jukema, J.W. (Jan Wouter), Kajantie, E. (Eero), Kamatani, Y. (Yoichiro), Kasbohm, E. (Elisa), Kaufman, J.-M. (Jean-Marc), Kiemeney, L.A. (Lambertus A.), Kloppenburg, M. (Margreet), Kronenberg, F. (Florian), Kubo, M. (Michiaki), Lahti, J. (Jari), Lapauw, B. (Bruno), Li, S. (Shuo), Liewald, D.C.M. (David C. M.), Alizadeh, B.Z. (Behrooz), Boezen, H.M. (Marike), Franke, L. (Lude), van der Harst, P. (Pim), Navis, G. (Gerjan), Rots, M.G. (M.), Snieder, H. (Harold), Swertz, M.A. (Morris A.), Wijmenga, C. (Cisca), Lim, E.M. (Ee Mun), Linneberg, A. (Allan), Marina, M. (Michela), Mascalzoni, D. (Deborah), Matsuda, K. (Koichi), Medenwald, D. (Daniel), Meisinger, C. (Christa), Meulenbelt, I. (Ingrid), Meyer, T. (Thorsten), Meyer zu Schwabedissen, H.E. (Henriette E.), Mikolajczyk, R. (Rafael), Moed, H. (Heleen), Netea-Maier, R.T. (Romana), Nolte, I.M. (Ilja), Okada, Y. (Yukinori), Pala, M. (Mauro), Penninx, B.W.J.H., Pedersen, O. (Oluf), Petersmann, A. (Astrid), Porcu, E. (Eleonora), Postmus, D. (Douwe), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Ramos, Y.F.M. (Yolande F. M.), Rawal, R. (Rajesh), Redmond, P. (Paul), Richards, J.B. (Brent), Rietzschel, E.R. (Ernst), Rivadeneira Ramirez, F. (Fernando), Roef, G.L. (Greet), Rotter, J.I. (Jerome I.), Sala, C. (Cinzia), Schlessinger, D. (David), Selvin, E. (Elizabeth), Slagboom, P.E. (Eline), Soranzo, N. (Nicole), Sørensen, T.I.A. (Thorkild), Spector, T.D. (Timothy), Starr, J.M. (John), Stott, D.J. (David. J.), Taes, Y.E. (Youri), Taliun, D. (Daniel), Tanaka, T. (Toshiko), Thuesen, L. (Leif), Tiller, D. (Daniel), Toniolo, D. (Daniela), Uitterlinden, A.G. (Andre G.), Visser, W.E. (Edward), Walsh, J.P. (John P.), Wilson, S.G. (Scott), Wolffenbuttel, B.H.R. (Bruce), Yang, Q. (Qiong Fang), Zheng, H.-F. (Hou-Feng), Cappola, A.R. (Anne), Peeters, R.P. (Robin), Naitza, S. (Silvia), Völzke, H. (Henry), Sanna, S. (Serena), Köttgen, A. (Anna), Visser, T.J. (Theo), Medici, M. (Marco), Teumer, A. (Alexander), Chaker, L. (Layal), Groeneweg, S. (Stefan), Li, Y. (Yong), Di Munno, C. (Celia), Barbieri, C. (Caterina), Schultheiss, U.T. (Ulla T.), Traglia, M. (Michela), Ahluwalia, T.S. (Tarunveer Singh), Akiyama, M. (Masato), Appel, E.V.R. (Emil Vincent R.), Arking, D.E. (Dan), Arnold, A.M. (Alice), Astrup, A. (Arne), Beekman, M. (Marian), Beilby, J.P. (John), Bekaert, S. (Sofie), Boerwinkle, E. (Eric), Brown, S.J. (Stephen), Buyzere, M. (Marc) de, Campbell, P.J. (Purdey J.), Ceresini, G. (Graziano), Cerqueira, C. (Charlotte), Cucca, F. (Francesco), Deary, I.J. (Ian), Deelen, J. (Joris), Eckardt, K.-U. (Kai-Uwe), Ekici, A.B. (Arif B.), Hagen, K. (Knut), Ferrrucci, L. (Luigi), Fiers, T. (Tom), Fiorillo, E. (Edoardo), Ford, I. (Ian), Fox, C.S. (Caroline), Fuchsberger, C. (Christian), Galesloot, T.E. (Tessel), Gieger, C. (Christian), Gögele, M. (Martin), Grandi, A. (Alessandro) de, Grarup, N. (Niels), Greiser, K.H. (Karin Halina), Haljas, K. (Kadri), Hansen, T. (Torben), Harris, S.E. (Sarah), Heemst, D. (Diana) van, Heijer, M. (Martin) den, Hicks, A.A. (Andrew A.), Hollander, W. (Wouter) den, Homuth, G. (Georg), Hui, J. (Jennie), Ikram, M.A. (Arfan), Ittermann, T. (Till), Jensen, R.A. (Richard A.), Jing, J. (Jiaojiao), Jukema, J.W. (Jan Wouter), Kajantie, E. (Eero), Kamatani, Y. (Yoichiro), Kasbohm, E. (Elisa), Kaufman, J.-M. (Jean-Marc), Kiemeney, L.A. (Lambertus A.), Kloppenburg, M. (Margreet), Kronenberg, F. (Florian), Kubo, M. (Michiaki), Lahti, J. (Jari), Lapauw, B. (Bruno), Li, S. (Shuo), Liewald, D.C.M. (David C. M.), Alizadeh, B.Z. (Behrooz), Boezen, H.M. (Marike), Franke, L. (Lude), van der Harst, P. (Pim), Navis, G. (Gerjan), Rots, M.G. (M.), Snieder, H. (Harold), Swertz, M.A. (Morris A.), Wijmenga, C. (Cisca), Lim, E.M. (Ee Mun), Linneberg, A. (Allan), Marina, M. (Michela), Mascalzoni, D. (Deborah), Matsuda, K. (Koichi), Medenwald, D. (Daniel), Meisinger, C. (Christa), Meulenbelt, I. (Ingrid), Meyer, T. (Thorsten), Meyer zu Schwabedissen, H.E. (Henriette E.), Mikolajczyk, R. (Rafael), Moed, H. (Heleen), Netea-Maier, R.T. (Romana), Nolte, I.M. (Ilja), Okada, Y. (Yukinori), Pala, M. (Mauro), Penninx, B.W.J.H., Pedersen, O. (Oluf), Petersmann, A. (Astrid), Porcu, E. (Eleonora), Postmus, D. (Douwe), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Ramos, Y.F.M. (Yolande F. M.), Rawal, R. (Rajesh), Redmond, P. (Paul), Richards, J.B. (Brent), Rietzschel, E.R. (Ernst), Rivadeneira Ramirez, F. (Fernando), Roef, G.L. (Greet), Rotter, J.I. (Jerome I.), Sala, C. (Cinzia), Schlessinger, D. (David), Selvin, E. (Elizabeth), Slagboom, P.E. (Eline), Soranzo, N. (Nicole), Sørensen, T.I.A. (Thorkild), Spector, T.D. (Timothy), Starr, J.M. (John), Stott, D.J. (David. J.), Taes, Y.E. (Youri), Taliun, D. (Daniel), Tanaka, T. (Toshiko), Thuesen, L. (Leif), Tiller, D. (Daniel), Toniolo, D. (Daniela), Uitterlinden, A.G. (Andre G.), Visser, W.E. (Edward), Walsh, J.P. (John P.), Wilson, S.G. (Scott), Wolffenbuttel, B.H.R. (Bruce), Yang, Q. (Qiong Fang), Zheng, H.-F. (Hou-Feng), Cappola, A.R. (Anne), Peeters, R.P. (Robin), Naitza, S. (Silvia), Völzke, H. (Henry), Sanna, S. (Serena), Köttgen, A. (Anna), Visser, T.J. (Theo), and Medici, M. (Marco)
- Abstract
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves’ disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets.
- Published
- 2018
- Full Text
- View/download PDF
21. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
- Author
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Teumer, A, Chaker, Layal, Groeneweg, Stefan, Li, Yi, Di Munno, Celia, Barbieri, C, Schultheiss, UT, Traglia, M, Ahluwalia, TS, Akiyama, M, Appel, EVR, Arking, DE, Arnold, A, Astrup, A, Beekman, M, Beilby, JP, Bekaert, S, Boerwinkle, E, Brown, SJ, de Buyzere, M, Campbell, PJ, Ceresini, G, Cerqueira, C, Cucca, F, Deary, IJ, Deelen, J, Eckardt, KU, Ekici, AB, Eriksson, JG, Ferrrucci, L, Fiers, T, Fiorillo, E, Ford, I, Fox, CS, Fuchsberger, C, Galesloot, TE, Gieger, C, Gogele, M, De Grandi, A, Grarup, N, Greiser, KH, Haljas, K, Hansen, T, Harris, SE, van Heemst, D, Heijer, M, Hicks, AA, den Hollander, W, Homuth, G, Hui, JN, Ikram, Arfan, Ittermann, T, Jensen, RA, Jing, J, Jukema, JW, Kajalltie, E, Kamatani, Y, Kasbohm, E, Kaufman, JM, Kiemeney, LA, Kloppenburg, M, Kronenberg, F, Kubo, M, Lahti, J, Lapauw, B, Li, S, Liewald, DCM, Lim, EM, Linneberg, A, Marina, M, Mascalzoni, D, Matsuda, K, Medenwald, D, Meisinger, C, Meulenbelt, I, Meyer, T, zu Schwabedissen, HEM, Mikolajczyk, R, Moed, M, Netea-Maier, RT, Nolte, IM, Okadah, Y, Pala, M, Pattaro, C, Pedersen, O, Petersmann, A, Porcu, E, Postmus, I, Pramstaller, PP, Psaty, BM, Ramos, YFM, Rawal, R, Redmond, P, Richards, JB, Rietzschel, ER, Rivadeneira, Fernando, Roef, G, Rotter, JI, Sala, CF, Schlessinger, D, Selvin, E, Slagboom, PE (Eline), Soranzo, N, Sorensen, TIA, Spector, TD, Starr, JM, Stott, DJ, Taes, Y, Taliun, D, Tanaka, T, Thuesen, B, Tiller, D, Toniolo, D, Uitterlinden, André, Visser, Edward, Walsh, JP, Wilson, SG, Wolffenbuttel, BHR, Yang, Q, Zheng, HF, Cappola, A, Peeters, Robin, Naitza, S, Volzke, H, Sanna, S, Kottgen, A, Visser, Theo, Medici, Marco, Teumer, A, Chaker, Layal, Groeneweg, Stefan, Li, Yi, Di Munno, Celia, Barbieri, C, Schultheiss, UT, Traglia, M, Ahluwalia, TS, Akiyama, M, Appel, EVR, Arking, DE, Arnold, A, Astrup, A, Beekman, M, Beilby, JP, Bekaert, S, Boerwinkle, E, Brown, SJ, de Buyzere, M, Campbell, PJ, Ceresini, G, Cerqueira, C, Cucca, F, Deary, IJ, Deelen, J, Eckardt, KU, Ekici, AB, Eriksson, JG, Ferrrucci, L, Fiers, T, Fiorillo, E, Ford, I, Fox, CS, Fuchsberger, C, Galesloot, TE, Gieger, C, Gogele, M, De Grandi, A, Grarup, N, Greiser, KH, Haljas, K, Hansen, T, Harris, SE, van Heemst, D, Heijer, M, Hicks, AA, den Hollander, W, Homuth, G, Hui, JN, Ikram, Arfan, Ittermann, T, Jensen, RA, Jing, J, Jukema, JW, Kajalltie, E, Kamatani, Y, Kasbohm, E, Kaufman, JM, Kiemeney, LA, Kloppenburg, M, Kronenberg, F, Kubo, M, Lahti, J, Lapauw, B, Li, S, Liewald, DCM, Lim, EM, Linneberg, A, Marina, M, Mascalzoni, D, Matsuda, K, Medenwald, D, Meisinger, C, Meulenbelt, I, Meyer, T, zu Schwabedissen, HEM, Mikolajczyk, R, Moed, M, Netea-Maier, RT, Nolte, IM, Okadah, Y, Pala, M, Pattaro, C, Pedersen, O, Petersmann, A, Porcu, E, Postmus, I, Pramstaller, PP, Psaty, BM, Ramos, YFM, Rawal, R, Redmond, P, Richards, JB, Rietzschel, ER, Rivadeneira, Fernando, Roef, G, Rotter, JI, Sala, CF, Schlessinger, D, Selvin, E, Slagboom, PE (Eline), Soranzo, N, Sorensen, TIA, Spector, TD, Starr, JM, Stott, DJ, Taes, Y, Taliun, D, Tanaka, T, Thuesen, B, Tiller, D, Toniolo, D, Uitterlinden, André, Visser, Edward, Walsh, JP, Wilson, SG, Wolffenbuttel, BHR, Yang, Q, Zheng, HF, Cappola, A, Peeters, Robin, Naitza, S, Volzke, H, Sanna, S, Kottgen, A, Visser, Theo, and Medici, Marco
- Published
- 2018
22. Arterial stiffness and influences of the metabolic syndrome: A cross-countries study
- Author
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Scuteri, A., Cunha, P. G., AGABITI ROSEI, Enrico, Badariere, J., Bekaert, S., Cockcroft, J. R., Cotter, J., Cucca, F., M. L., De, Meyer, T. D., Ferrucci, L., Franco, O., Gale, N., Gillebert, T. C., Langlois, M., Laucevicius, A., Laurent, S., F. U. S., Morrell, C. H., Muiesan, Maria Lorenza, Munnery, M. M., Navickas, R., Oliveira, P., Orru', M., Pilia, M. G., Rietzschel, E. R., Ryliskyte, L., Salvetti, Massimo, Schlessinger, D., Sousa, N., Stefanadis, C., Strait, J., Daele, C. V., Villa, I., Vlachopoulos, C., Witteman, J., Xaplanteris, P., Nilsson, P., Lakatta, E. G., Hofman, A., M. A. R., Universidade do Minho, Epidemiology, and Internal Medicine
- Subjects
Male ,Comorbidity ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Pulse wave velocity ,Abdominal obesity ,Metabolic Syndrome ,education.field_of_study ,arterial stiffness, metabolic syndrome, aortic stiffness ,Anthropometry ,Smoking ,Middle Aged ,Arterial stiffness ,Metabolic syndrome ,3. Good health ,Europe ,Hypertension ,Cohort ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,aortic stiffness ,Population ,Pulse Wave Analysis ,Article ,03 medical and health sciences ,Sex Factors ,Vascular Stiffness ,SDG 3 - Good Health and Well-being ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Humans ,Cross-cultural comparison ,Risk factor ,education ,Aged ,Dyslipidemias ,Science & Technology ,business.industry ,medicine.disease ,United States ,Cross-Sectional Studies ,Endocrinology ,business - Abstract
Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in >= 3 of the 5 components: abdominal obesity (W), high triglycerides (T), low HDL cholesterol (H), elevated blood pressure (B), and elevated fasting glucose (G). PWV measured in each cohort was "normalized" to account for different acquisition methods. MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components - even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus - in all the MARE cohorts. In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV). (C) 2014 Elsevier Ireland Ltd. All rights reserved., NIH -National Institutes of Health
- Published
- 2014
23. Zur Kälteadaptation während körperlicher Leistung — Vorläufige Ergebnisse
- Author
-
Vogelaere, P., Bekaert, S., Leclercq, R., Brasseur, M., Quirion, A., Dulac, S., Franz, Ingomar-Werner, editor, Mellerowicz, Harald, editor, and Noack, Wolfgang, editor
- Published
- 1985
- Full Text
- View/download PDF
24. Gender and telomere length:Systematic review and meta-analysis
- Author
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Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin Ruiz C, Shiels P, Sayer AA, BARBIERI, Michelangela, Bekaert S, Bischoff C, Brooks Wilson A, Chen W, Cooper C, Christensen K, De Meyer T, Deary I, Der G, Roux AD, Fitzpatrick A, Hajat A, Halaschek Wiener J, Harris S, Hunt SC, Jagger C, Jeon HS, Kaplan R, Kimura M, Lansdorp P, Li C, Maeda T, Mangino M, Nawrot TS, Nilsson P, Nordfjall K, Ren F, Riabowol K, Robertson T, Roos G, Staessen JA, Spector T, Tang N, Unryn B, van der Harst P, Woo J, Xing C, Yadegarfar ME, Park JY, Young N, Kuh D, vonZglinicki T, Ben Shlomo Y, the Halcyon study team, PAOLISSO, Giuseppe, Gardner, M, Bann, D, Wiley, L, Cooper, R, Hardy, R, Nitsch, D, Martin Ruiz, C, Shiels, P, Sayer, Aa, Barbieri, Michelangela, Bekaert, S, Bischoff, C, Brooks Wilson, A, Chen, W, Cooper, C, Christensen, K, De Meyer, T, Deary, I, Der, G, Roux, Ad, Fitzpatrick, A, Hajat, A, Halaschek Wiener, J, Harris, S, Hunt, Sc, Jagger, C, Jeon, H, Kaplan, R, Kimura, M, Lansdorp, P, Li, C, Maeda, T, Mangino, M, Nawrot, T, Nilsson, P, Nordfjall, K, Paolisso, Giuseppe, Ren, F, Riabowol, K, Robertson, T, Roos, G, Staessen, Ja, Spector, T, Tang, N, Unryn, B, van der Harst, P, Woo, J, Xing, C, Yadegarfar, Me, Park, Jy, Young, N, Kuh, D, Vonzglinicki, T, Ben Shlomo, Y, and the Halcyon study, Team
- Published
- 2014
25. 07.06 Long Term Oral Contraceptive use is an Independent Risk Factor for Arterial Stiffening
- Author
-
Rietzschel, E. R., De Buyzere, M. L., Segers, P., Bekaert, S., De Bacquer, D., De Backer, G. G., and Gillebert, T. C.
- Published
- 2008
- Full Text
- View/download PDF
26. In vivo low thermal degradation of monolithic zirconia restorations
- Author
-
Wulfman, C., primary, Koenig, V., additional, Dupont, N., additional, Bekaert, S., additional, Le Goff, S., additional, Eldafrawy, M., additional, Martin, G., additional, Vanheusden, A., additional, and Mainjot, A., additional
- Published
- 2017
- Full Text
- View/download PDF
27. Reproducibility of telomere length assessment: an international collaborative study
- Author
-
Cooper, Rachel, Martin-Ruiz, CM, Baird, D, Roger, L, Boukamp, P, Krunic, D, Cawthon, R, Dokter, MM, van, der Harst P, Bekaert, S, de, Meyer T, Roos, G, Svenson, U, Codd, V, Samani, NJ, McGlynn, L, Shiels, PG, Pooley, KA, Dunning, AM, Cooper, R, Wong, A, Kingston, A, and von, Zglinicki T
- Abstract
Background: Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and uncertainty regarding the present limits of measurement reproducibility within and between laboratories. Methods: We instigated an international collaborative study of telomere length assessment: 10 different laboratories, employing 3 different techniques [Southern blotting, single telomere length analysis (STELA) and real-time quantitative PCR (qPCR)] performed two rounds of fully blinded measurements on 10 human DNA samples per round to enable unbiased assessment of intra- and inter-batch variation between laboratories and techniques. Results: Absolute results from different laboratories differed widely and could thus not be compared directly, but rankings of relative telomere lengths were highly correlated (correlation coefficients of 0.63–0.99). Intra-technique correlations were similar for Southern blotting and qPCR and were stronger than inter-technique ones. However, inter-laboratory coefficients of variation (CVs) averaged about 10% for Southern blotting and STELA and more than 20% for qPCR. This difference was compensated for by a higher dynamic range for the qPCR method as shown by equal variance after z-scoring. Technical variation per laboratory, measured as median of intra- and inter-batch CVs, ranged from 1.4% to 9.5%, with differences between laboratories only marginally significant ( P = 0.06). Gel-based and PCR-based techniques were not different in accuracy. Conclusions: Intra- and inter-laboratory technical variation severely limits the usefulness of data pooling and excludes sharing of reference ranges between laboratories. We propose to establish a common set of physical telomere length standards to improve comparability of telomere length estimates between laboratories.
- Published
- 2014
28. Variations cardio-respiratoires et metaboliques à l'effort sous-maximal (P=40% Pmax) et maximal (Vita Max) en conditions thermiques froide (0‡C) et neutre (20‡C)
- Author
-
Vogelaere, P., Quirion, A., Leclercq, R., Bekaert, S., and Brasseur, M.
- Published
- 1986
- Full Text
- View/download PDF
29. Role of adamalysin proteases in modulations of tumor microenvironment and premetastatic niches
- Author
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Donati, K., primary, Bekaert, S., additional, Sepult, S., additional, Noel, A., additional, Rocks, N., additional, and Cataldo, D., additional
- Published
- 2015
- Full Text
- View/download PDF
30. Arterial stiffness and influences of the metabolic syndrome: A cross-countries study
- Author
-
Scuteri, A, Cunha, PG, Rosei, EA, Badariere, J, Bekaert, S, Cockcroft, JR, Cotter, J, Cucca, F, De Buyzere, ML, Meyer, T, Ferrucci, L, Franco, O, Gale, N, Gillebert, TC, Hofman, Bert, Langlois, M, Laucevicius, A, Laurent, S, Mattace Raso, F.U.S., Morrell, CH, Muiesan, ML, Munnery, MM, Navickas, R, Oliveira, P, Orru', M, Pilia, MG, Rietzschel, ER, Ryliskyte, L, Salvetti, M, Schlessinger, D, Sousa, N, Stefanadis, C, Strait, J, Van Daele, C, Villa, I, Vlachopoulos, C, Witteman, JCM, Xaplanteris, P, Nilsson, P, Lakatta, EG, Scuteri, A, Cunha, PG, Rosei, EA, Badariere, J, Bekaert, S, Cockcroft, JR, Cotter, J, Cucca, F, De Buyzere, ML, Meyer, T, Ferrucci, L, Franco, O, Gale, N, Gillebert, TC, Hofman, Bert, Langlois, M, Laucevicius, A, Laurent, S, Mattace Raso, F.U.S., Morrell, CH, Muiesan, ML, Munnery, MM, Navickas, R, Oliveira, P, Orru', M, Pilia, MG, Rietzschel, ER, Ryliskyte, L, Salvetti, M, Schlessinger, D, Sousa, N, Stefanadis, C, Strait, J, Van Daele, C, Villa, I, Vlachopoulos, C, Witteman, JCM, Xaplanteris, P, Nilsson, P, and Lakatta, EG
- Abstract
Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in >= 3 of the 5 components: abdominal obesity (W), high triglycerides (T), low HDL cholesterol (H), elevated blood pressure (B), and elevated fasting glucose (G). PWV measured in each cohort was "normalized" to account for different acquisition methods. MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components - even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus - in all the MARE cohorts. In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV). (C) 2014 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2014
31. Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis
- Author
-
Pichavant, M, primary, Rémy, G, additional, Bekaert, S, additional, Le Rouzic, O, additional, Kervoaze, G, additional, Vilain, E, additional, Just, N, additional, Tillie-Leblond, I, additional, Trottein, F, additional, Cataldo, D, additional, and Gosset, P, additional
- Published
- 2014
- Full Text
- View/download PDF
32. Curcumin–cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer
- Author
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Rocks, N, primary, Bekaert, S, additional, Coia, I, additional, Paulissen, G, additional, Gueders, M, additional, Evrard, B, additional, Van Heugen, J-C, additional, Chiap, P, additional, Foidart, J-M, additional, Noel, A, additional, and Cataldo, D, additional
- Published
- 2012
- Full Text
- View/download PDF
33. Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages
- Author
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Briquet, A., primary, Dubois, S., additional, Bekaert, S., additional, Dolhet, M., additional, Beguin, Y., additional, and Gothot, A., additional
- Published
- 2009
- Full Text
- View/download PDF
34. E2F s mediate a fundamental cell-cycle deregulation in high-grade serous ovarian carcinomas
- Author
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De Meyer, T, primary, Bijsmans, ITGW, additional, Van de Vijver, KK, additional, Bekaert, S, additional, Oosting, J, additional, Van Criekinge, W, additional, van Engeland, M, additional, and Sieben, NLG, additional
- Published
- 2008
- Full Text
- View/download PDF
35. In vitro validation of -secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
- Author
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De Keersmaecker, K., primary, Lahortiga, I., additional, Mentens, N., additional, Folens, C., additional, Van Neste, L., additional, Bekaert, S., additional, Vandenberghe, P., additional, Odero, M. D., additional, Marynen, P., additional, and Cools, J., additional
- Published
- 2008
- Full Text
- View/download PDF
36. PubMeth: a cancer methylation database combining text-mining and expert annotation
- Author
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Ongenaert, M., primary, Van Neste, L., additional, De Meyer, T., additional, Menschaert, G., additional, Bekaert, S., additional, and Van Criekinge, W., additional
- Published
- 2007
- Full Text
- View/download PDF
37. Relation between telomerase activity, hTERT and telomere length for intracranial tumours
- Author
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Maes, L., primary, Van Neste, L., additional, Van Damme, K., additional, Kalala, J., additional, De Ridder, L., additional, Bekaert, S., additional, and Cornelissen, M., additional
- Published
- 2007
- Full Text
- View/download PDF
38. Telomere length versus hormonal and bone mineral status in healthy elderly men
- Author
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Bekaert, S., primary, Van Pottelbergh, I., additional, De Meyer, T., additional, Zmierczak, H., additional, Kaufman, J.M., additional, Van Oostveldt, P., additional, and Goemaere, S., additional
- Published
- 2005
- Full Text
- View/download PDF
39. Comparing telomere length of sister chromatids in human lymphocytes using three‐dimensional confocal microscopy
- Author
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Bekaert, S., primary, Koll, S., additional, Thas, O., additional, and Van Oostveldt, P., additional
- Published
- 2002
- Full Text
- View/download PDF
40. Meeting the health needs of young offenders.
- Author
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Bekaert S
- Abstract
A recent review of health care for young people who offend recommended that youth offending teams should include healthcare provision. The type of provision that is common may not be meeting the general health needs of this vulnerable group who are known to have multiple health needs that can influence their offending behaviour. An advanced nurse practitioner/general health nurse piloted onsite general health provision, working alongside a multidisciplinary team supporting the young people attending a youth offending team in London. An audit of the first 70 clients confirmed the complex family, social, health and other factors affecting the lives of these young people. There was a significant amount of general health care needed among this group that was not being addressed and more than three quarters of the young people whose records were audited required follow-up by the general health nurse. A nurse who is trained to work with young people and able to deliver holistic health care complements the roles of the youth offending team's extended support team and enables young people to receive general health care and follow up onsite. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
41. Hématologie: Exercice exhaustif et environnement froid (0°C)
- Author
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Vogelaere, P, primary, Brasseur, M, additional, de Meyer, F, additional, Quirion, A, additional, Leclercq, R, additional, Laurencelle, L, additional, and Bekaert, S, additional
- Published
- 1990
- Full Text
- View/download PDF
42. Improving healthcare provision for teenagers.
- Author
-
Bekaert S
- Abstract
Sarah Bekaert has been looking at ways to improve services for young people at her north London practice. [ABSTRACT FROM AUTHOR]
- Published
- 2003
43. Sexual health workshops.
- Author
-
Bekaert S
- Subjects
- *
SEX education , *SCHOOL nursing , *TEENAGERS , *ADULT education workshops - Abstract
School nurses have a crucial role to play in helping the government achieve its aim to reduce teenage pregnancies. Sarah Bekaert describes how multidisciplinary sex education workshops in secondary schools tackle this issue. [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
44. Een Ceval Van Aneurysma Van De Arteria Renalis : Follow-up van
- Author
-
Bekaert S and Deloose F
- Subjects
medicine.medical_specialty ,Exacerbation ,medicine.diagnostic_test ,business.industry ,Renal Artery Obstruction ,General Medicine ,Blood flow ,Vascular surgery ,medicine.disease ,Surgery ,Aneurysm ,Blood pressure ,Angiography ,cardiovascular system ,medicine ,cardiovascular diseases ,business ,Left kidney - Abstract
SummaryThe authors relate the case of a woman aged 59 years who presented a sudden exacerbation of a former existing hypertension. A saccular aneurysm was found during aorto-renography in the lower pole of the left kidney. Renography and peroperative pressure recording indicated disminished blood flow to the lower pole.After resection of the aneurysm normalisation of blood How was regained with lowering of the blood pressure. These findings were confirmed two years after operation.
- Published
- 1964
45. Een Ceval Van Aneurysma Dissecans Van De Arteria Renalis
- Author
-
Deloose F and Bekaert S
- Subjects
Aortic dissection ,Kidney ,Aorta ,business.industry ,Renal Artery Obstruction ,General Medicine ,Dissection (medical) ,Anatomy ,urologic and male genital diseases ,medicine.disease ,medicine.anatomical_structure ,Aneurysm ,medicine.artery ,Renal blood flow ,cardiovascular system ,Medicine ,Renal artery ,business - Abstract
SummaryA case of dissecting aneurysm of the aorta with extension into the renal artery is descrilx'd Hypertension could be explained by decreased renal blood flow secondary to dissection of aorta at the origin of renal vessels or to thrombosis of the upper branch of renal artery with compression of the lower branch.A transient rise observed in acid phosphatase serum level supported the view that this enzyme of renal origin is liberated during kidney infarction.The thoracolumbar pain is ascribed to the dissecting aneurysm itself.It is known that intercostal and lumbar arteries may be obliterated or injured during aortic dissection.
- Published
- 1964
46. Long term oral contraceptive use is an independent risk factor for arterial stiffening
- Author
-
Rietzschel, E.R., De Buyzere, M.L., Segers, P., Bekaert, S., De Bacquer, D., De Backer, G.G., and Gillebert, T.C.
- Published
- 2008
- Full Text
- View/download PDF
47. ‘Why do I always get pregnant on the pill?’; reconceiving teenaged mothers’ repeat pregnancies
- Author
-
Bekaert, S.
- Subjects
RT - Abstract
Policy and research discourses tend to construct teenaged pregnancy and parenthood as negative and to be avoided. Current socio-political expectations in the UK for the teenaged years encompass commitment to education as a route to social mobility, and avoidance of pregnancy and parenthood that is assumed to disrupt this trajectory. If parenthood occurs in the teenaged years, it is problematized within policy discourses which associate young parenting with social exclusion. Teenaged women who become pregnant and abort are expected to return to education and are subject to targeted intervention to avoid repeat pregnancy.\ud \ud In a nurse outreach service in an inner London borough a small number of young women became mothers after an abortion whilst in the teenaged years. Commissioners saw this as a failure of an outreach programme and constructed the young women as a ‘hard to reach’ group. Troubled by such labelling, this exploratory qualitative study set out to explore the influence on teenaged women’s pregnancy decision-making specifically for those who had an abortion followed by birth. In-depth interviews were carried out with eight teenaged women in 2014.\ud \ud This study draws methodologically on feminist reflexivity and concepts of governmentality to attend to ways in which women’s sexuality is regulated through policy, clinical, and research practice. Whereas much research over-psychologises women’s reproductive decisions this thesis explicitly grounds the women’s narratives of these decisions in the context of their lives; often dominated by violence, poverty and uncertainty.\ud \ud Analysis indicates a tension between policy assumptions of individualised decision-making and the contextualised decisions of the young women. I observe that the further the distance between the expected trajectory for teenaged years and emerging personal desire for parenthood the greater the young women’s narratives were characterised by discourses of ‘responsibilisation’; convincing me of their ‘good citizenship’. I debate this as either a form of resistance, distancing themselves from the negative single teen mother stereotype or a lack of confidence to challenge such normalised expectations.\ud \ud Furthermore, deficit models of teenaged parenting fail to acknowledge the positives that young women report. This thesis challenges such deficit models and highlights the favourable elements of parenting described, and suggest that the young women struggle to articulate a desire for parenting within dominant discourses of prevention.
48. 'Losing' a pregnancy: Incentive toward rapid repeat pregnancy?
- Author
-
Bekaert, S.
- Subjects
RJ101 ,reproductive and urinary physiology - Abstract
Teenaged pregnancy: losing a pregnancy, an incentive toward rapid repeat pregnancy? \ud \ud Aims: to explore the influencing factors on pregnancy decision-making in relation to becoming a mother soon after an abortion whilst in the teenage years. To consider these factors in relation to the legacy of the Teenaged Pregnancy Strategy (SEU 1999) and societal expectations for motherhood and childhood. To trouble these normalised expectations for motherhood and childhood in relation to a 'lost' pregnancy (Clarke 2002) and a situated context of poverty and violence.
49. Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation
- Author
-
Abou-El-Ardat, K., Derradji, H., Bekaert, S., Meyer, T., Criekinge, W., and Sarah Baatout
- Subjects
Cell Survival ,Proto-Oncogene Proteins c-ret ,Tumor Cells, Cultured ,Humans ,Dose-Response Relationship, Radiation ,Thyroid Neoplasms ,Carcinoma, Papillary ,Cell Division ,S Phase
50. On the utility of Fourier analysis of left ventricular pressure
- Author
-
Bernard, P. J., primary, Bourgain, R., additional, Vermariën, H., additional, and Bekaert, S., additional
- Published
- 1976
- Full Text
- View/download PDF
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