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Cuminaldehyde (CA) is one of the major compounds of the essential oil of Cuminum cyminum. The aim of this study was to evaluate the effects of CA on aging, specifically on spatial learning and memory. To achieve our objective, an in vitro study on SH-SY5Y cells was performed to analyze the neuroprotective effect of CA against dexamethasone using the MTT assay. An in vivo study was performed for evaluation of the spatial learning and memory using Morris water maze (MWM). RT-PCR was performed to quantify the expression of specific genes (Bdnf, Icam and ApoE) in the mice brain. The results obtained showed a neuroprotective effect of CA against dexamethasone-induced neuronal toxicity. The escape latency of CA-treated aged mice was significantly decreased as compared to the water-treated aged mice after 4 days of training in MWM. Moreover, CA treatment up-regulated the gene expression of Bdnf, Icam and ApoE, while it down-regulated the gene expression of IL-6. These findings suggest that CA has a neuroprotective effect, as well as a spatial learning and memory enhancement potential through the modulation of genes coding for neurotrophic factors and/or those implicated in the imbalance of neural circuitry and impairment of synaptic plasticity. Cuminaldehyde (CA) is one of the major compound of the essential oil of Cuminum cyminum. The aim of this study was to evaluate the effects of CA on aging, specifically on spatial learning and memory. To achieve our objective, an in vitro study on SH-SY5Y cells was performed to analyze the neuroprotective effect of CA against dexamethasone using the MTT assay. An in vivo study was performed for evaluation of the spatial learning and memory using Morris water maze (MWM). RT-PCR was performed to quantify the expression of specific genes (Bdnf, Icam and ApoE) in the mice brain. The results obtained showed a neuroprotective effect of CA against dexamethasone-induced neuronal toxicity. The escape latency of CA-treated aged mice was significantly decreased as compared to the water-treated aged mice after 4 days of training in MWM. Moreover, CA treatment up-regulated the gene expression of Bdnf, Icam and ApoE, while it down-regulated the gene expression of IL-6. These findings suggest that CA has a neuroprotective effect, as well as a spatial learning and memory enhancement potential through the modulation of genes coding for neurotrophic factors and/or those implicated in the imbalance of neural circuitry and impairment of synaptic plasticity.

Parmi les indicateurs de qualité et sécurité des soins (IQSS), ceux constituant le tableau de bord des infections associées aux soins (IAS) ont été un levier majeur dans l’amélioration de l’organisation, des moyens et des actions mises en œuvre par les établissements de santé français pour prévenir et lutter contre ces infections. Douze ans après la diffusion du premier de ces indicateurs, ces établissements ont progressé dans la maîtrise du risque infectieux. Logiquement, les IQSS doivent donc évoluer. Pour cela, depuis 2018, la Haute Autorité de santé (HAS) s’est fixée comme objectif une refonte totale des indicateurs IAS, en prenant en compte les avis et les conclusions des différents acteurs. Cela a abouti à l’élaboration de nouveaux indicateurs de processus qui restent à expérimenter et à valider. Ils vont compléter le premier indicateur de résultat du thème IAS, qui mesure le ratio standardisé (observé/attendu) des infections du site opératoire trois mois après la pose de prothèse totale de hanche ou de genou (ISO_Ortho), et l’indicateur de consommation des solutions hydro-alcooliques dans sa version 3 (Icsha.3). Par ailleurs, le support du recueil d’informations, initialement assuré par le tableau de bord des infections nosocomiales, évoluera désormais en parallèle et ne sera plus utilisé pour le calcul des IQSS. Cet article présente la démarche adoptée par la HAS et l’état actuel des propositions d’évolution vers de nouveaux indicateurs pour les établissements de santé français.