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Antibiotic contamination from hospitals, animal husbandry, and municipal wastewater is graver than imagined, and it possess serious risks to the health of humans and animals, with the emergence of multidrug resistant bacteria; those affect the growth of higher plants too. Conventional wastewater treatment methods adopted today are inadequate for removing antibiotics from wastewater. Intuitively, the remediation process using mixed algae should be effective enough, for which algae-based remediation technologies have emerged as sustainable remedial methods. This review summarized the detection of antibiotics in field water in most countries; a comprehensive overview of algae-based technologies, algal adsorption, accumulation, biodegradation, photodegradation, hydrolysis, and the use of algae-bacteria consortia for the remediation of antibiotics in wastewaters in done. Green algae namely, Chlamydomonas sp., Chlorella sp., C. vulgaris, Spyrogira sp. Scenedesmus quadricauda, S. obliquus, S. dimorphus, Haematoccus pluvialis, and Nannochlopsis sp., had been reporting have 90–100% antibiotic removal efficiency. The integration of bioelectrochemical systems and genetically engineered prokaryotic algal species offer promising avenues for improving antibiotic removal in the future. Overall, this review highlights the need for tenacious research and development of algae-based technologies to reduce antibiotic contamination in aquatic environments, for holistic good. [ABSTRACT FROM AUTHOR]