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23 results on '"Beitzen-Heineke, Antonia"'

6. Prolonged inhibition of intratumoral mast cells enhances efficacy of low‐dose antiangiogenic therapy.

Author

Berenbrok, Nikolaus, Vargas‐Delgado, Maria Elena, Beitzen‐Heineke, Antonia, Schmidt, Claudia, Gensch, Victoria, Loges, Sonja, and Ben‐Batalla, Isabel

Subjects
MAST cells, ANIMAL models in research, CELLULAR therapy, IMATINIB, IMMUNE response
Abstract

Low‐dose antiangiogenic therapies have demonstrated the ability to enhance normalization of tumor vessels, consequently improving hypoxia levels, drug delivery, and promoting anticancer immune responses. Mast cells have been identified as contributors to resistance against antiangiogenic therapy and facilitators of abnormal neoangiogenesis. In this study, we demonstrate that by simultaneously targeting intratumoral mast cells with Imatinib and administering low‐dose anti‐VEGFR2 therapy, antitumor efficacy can be enhanced in preclinical models. Thus, combinatory treatment overcomes therapy resistance, while concurrently promoting tumor vessel normalization. Notably, histomorphometric analysis of tumor sections revealed that vessel perfusion could be improved through mast cell inhibition and, despite a significantly reduced microvessel density, the combination treatment did not result in elevated tumor hypoxia levels compared to anti‐VEGFR2 therapy alone. Short‐term Imatinib application effectively increased antitumor efficacy, and by prolonging the application of Imatinib tumor vessel normalization was additionally improved. The combination of mast cell depletion and antiangiogenic treatments has not been investigated in detail and promises to help overcoming therapy resistance. Further studies will be required to explore their impact on other treatment approaches, and subsequently to validate these findings in a clinical setting. [ABSTRACT FROM AUTHOR]

Published
2025
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8. Myocardial injury detected by T1 and T2 mapping on CMR predicts subsequent cancer therapy–related cardiac dysfunction in patients with breast cancer treated by epirubicin-based chemotherapy or left-sided RT

Author

Tahir, Enver, Azar, Manuella, Shihada, Sahar, Seiffert, Katharina, Goy, Yvonne, Beitzen-Heineke, Antonia, Molwitz, Isabel, Muellerleile, Kai, Stehning, Christian, Schön, Gerhard, Adam, Gerhard, Petersen, Cordula, Müller, Volkmar, and Lund, Gunnar K.

Published
2022
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9. Regulation of bone homeostasis by MERTK and TYRO3

Author

Engelmann, Janik, Zarrer, Jennifer, Gensch, Victoria, Riecken, Kristoffer, Berenbrok, Nikolaus, Luu, The Vinh, Beitzen-Heineke, Antonia, Vargas-Delgado, Maria Elena, Pantel, Klaus, Bokemeyer, Carsten, Bhamidipati, Somasekhar, Darwish, Ihab S., Masuda, Esteban, Burstyn-Cohen, Tal, Alberto, Emily J., Ghosh, Sourav, Rothlin, Carla, Hesse, Eric, Taipaleenmäki, Hanna, Ben-Batalla, Isabel, and Loges, Sonja

Published
2022
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14. Left ventricular diastolic filling patterns in competitive triathletes with and without myocardial fibrosis by cardiac magnetic resonance time-volume analysis

Author

Chen, Hang, primary, Jungesblut, Johanna, additional, Saering, Dennis, additional, Muellerleile, Kai, additional, Beitzen-Heineke, Antonia, additional, Harms, Phillip, additional, Erley, Jennifer, additional, Schoennagel, Bjoern, additional, Schneider, Jan N., additional, Cavus, Ersin, additional, Fischer, Roland, additional, Lund, Gunnar K., additional, Adam, Gerhard, additional, and Tahir, Enver, additional

Published
2023
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16. Acute impact of an endurance race on biventricular and biatrial myocardial strain in competitive male and female triathletes evaluated by feature-tracking CMR

Author

Chen, Hang, primary, Warncke, Malte L., additional, Muellerleile, Kai, additional, Saering, Dennis, additional, Beitzen-Heineke, Antonia, additional, Kisters, Anna, additional, Swiderska, Monika, additional, Cavus, Ersin, additional, Jahnke, Charlotte M., additional, Adam, Gerhard, additional, Lund, Gunnar K., additional, and Tahir, Enver, additional

Published
2021
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17. Myocardial injury detected by T1 and T2 mapping on CMR predicts subsequent cancer therapy–related cardiac dysfunction in patients with breast cancer treated by epirubicin-based chemotherapy or left-sided RT

Author

Tahir, Enver, primary, Azar, Manuella, additional, Shihada, Sahar, additional, Seiffert, Katharina, additional, Goy, Yvonne, additional, Beitzen-Heineke, Antonia, additional, Molwitz, Isabel, additional, Muellerleile, Kai, additional, Stehning, Christian, additional, Schön, Gerhard, additional, Adam, Gerhard, additional, Petersen, Cordula, additional, Müller, Volkmar, additional, and Lund, Gunnar K., additional

Published
2021
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18. AXL Inhibition Represents a Novel Therapeutic Approach in BCR-ABL Negative Myeloproliferative Neoplasms

Author

Beitzen-Heineke, Antonia, primary, Berenbrok, Nikolaus, additional, Waizenegger, Jonas, additional, Paesler, Sarina, additional, Gensch, Victoria, additional, Udonta, Florian, additional, Vargas Delgado, Maria Elena, additional, Engelmann, Janik, additional, Hoffmann, Friederike, additional, Schafhausen, Philippe, additional, von Amsberg, Gunhild, additional, Riecken, Kristoffer, additional, Beumer, Niklas, additional, Imbusch, Charles D., additional, Lorens, James, additional, Fischer, Thomas, additional, Pantel, Klaus, additional, Bokemeyer, Carsten, additional, Ben-Batalla, Isabel, additional, and Loges, Sonja, additional

Published
2021
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19. Loss of CD22 expression and expansion of a CD22dim subpopulation in adults with relapsed/refractory B-lymphoblastic leukaemia after treatment with Inotuzumab-Ozogamicin.

Author

Reinert, Jochim, Beitzen-Heineke, Antonia, Wethmar, Klaus, Stelljes, Matthias, Fiedler, Walter, and Schwartz, Stefan

Subjects
ADULTS, TREATMENT effectiveness, LEUKEMIA, PROGNOSIS, FLOW cytometry
Abstract

Treatment options for relapsed or refractory B-lymphoblastic leukaemia (r/r B-ALL) are limited and the prognosis of these patients remains dismal, but novel immunotherapeutic options such as the anti-CD22 antibody–drug-conjugate Inotuzumab-Ozogamicin (InO) have improved outcomes in these patients. Flow cytometry is essential to assess antigen-expression prior to treatment initiation of antigen-directed immunotherapies. Here, we present flow cytometric and clinical data of three adult patients with r/r B-ALL who failed treatment with InO associated with reduced or lost antigen-expression. In addition, we present comparative data on two different diagnostic CD22-specific antibody clones that exhibit significant differences in staining intensities. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Therapeutic Potential of Axl Blockade in BCR-ABL Negative Myeloproliferative Neoplasms (MPN)

Author

Beitzen-Heineke, Antonia, primary, Ben Batalla, Isabel, additional, Berenbrok, Nikolaus, additional, Paesler, Sarina, additional, Gensch, Victoria, additional, von Amsberg, Gunhild, additional, Schafhausen, Philippe, additional, Riecken, Kristoffer, additional, Fischer, Thomas, additional, Pantel, Klaus, additional, Bokemeyer, Carsten, additional, and Loges, Sonja, additional

Published
2018
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22. Invariant Natural Killer T cells possess immune-modulating functions during \(Aspergillus\) \(fumigatus\) infection

Author

Beitzen-Heineke, Antonia

Subjects
Aspergillus fumigatus, hemic and immune systems, chemical and pharmacologic phenomena, T Zelle, ddc:610
Abstract

Aspergillus fumigatus is the most common cause for invasive fungal infections, a disease associated with high mortality in immune-compromised patients. CD1d-restricted invariant Natural Killer T (iNKT) cells compose a small subset of T cells known to impact the immune response towards various infectious pathogens. To investigate the role of human iNKT cells during A. fumigatus infection, we studied their activation as determined by CD69 expression and cytokine production in response to distinct fungal morphotypes in the presence of different CD1d⁺ antigen presenting cells using flow cytometry and multiplex ELISA. Among CD1d⁺ subpopulations, CD1d⁺CD1c⁺ mDCs showed the highest potential to activate iNKT cells on a per cell basis. The presence of A. fumigatus decreased this effect of CD1d⁺CD1c⁺ mDCs on iNKT cells and led to reduced secretion of TNF-α, G-CSF and RANTES. Production of other Th1 and Th2 cytokines was not affected by the fungus, suggesting an immune-modulating function for human iNKT cells during A. fumigatus infection., Aspergillus fumigatus ist der häufigste Erreger von invasiven Pilzinfektionen, welche bei immunsupprimierten Patienten mit einer hohen Mortalität einhergehen. CD1d-abhängige invariante Natürliche Killer T (iNKT) Zellen sind eine kleine Subpopulation von T-Zellen, die die Immunantwort auf verschiedene Erreger beeinflussen. Um die Rolle von humanen iNKT Zellen in der Aspergillus fumigatus Abwehr zu untersuchen, wurde in Ko-Kulturen mit iNKT Zellen und CD1d⁺ Antigen präsentierenden Zellen in Anwesenheit von verschiedenen fungalen Morphotypen der Aktivierungsmarker CD69 und die Zytokinproduktion mittels Durchflusszytometrie und Multiplex ELISA untersucht. Unter den CD1d⁺ Subpopulationen wiesen die CD1d⁺CD1c⁺mDCs das höchste aktivierende Potential auf iNKT Zellen auf. Die Anwesenheit von A. fumigatus reduzierte diesen Effekt von CD1d⁺CD1c⁺mDCs auf iNKT Zellen und führte zu einer reduzierten Sekretion von TNF-α, G-CSF und RANTES. Die Produktion von anderen Th1 und Th2 Zytokinen war nicht durch den Pilz beeinflusst. Diese Arbeit suggeriert eine immunmodulierende Funktion von humanen iNKT Zellen in der Abwehr von A. fumigatus.

Published
2015

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