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Your search keyword '"Behnoush Alizadeh"' showing total 2 results
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2 results on '"Behnoush Alizadeh"'

1. Robust Trajectory Tracking of Delta Parallel Robot Using Fractional-Order Sliding Mode Control

Author

Behnoush Alizadeh, Ahmad Hajipour, Hamidreza Tavakoli, and Abbas Nasrabadi

Subjects
Delta parallel robot, fractional-order sliding mode control, trajectory tracking, parameter estimation, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

In this study, a Fractional-Order Sliding Mode Control scheme is proposed for trajectory tracking control of Delta parallel robot. The proposed controller is compared with both integer-order Proportional-Derivative controller and integer-order Sliding Mode Controller with Computed Torque Control method. The forward kinematics, inverse kinematics and dynamic of Delta parallel robot are described. A Solidworks/Matlab/SimScape/Multibody model of Delta parallel robot is generated and used for dynamic parameter estimation and validation of the proposed method. Particle Swarm Optimization algorithm is utilized for dynamic parameter estimation of Delta parallel robot. The validation of the proposed method is evaluated for three different trajectories. External disturbances, noise and also various payloads are considered in testing robustness of control techniques. The results of the robustness tests confirm higher performance of FOSMC than two other control schemes.

Published
2023
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2. Prolonged injectable formulation of Nafarelin using in situ gel combination delivery system

Author

Farid Abedin Dorkoosh, Mohammad Reza Khoshayand, Hamid Akbari Javar, Nika Bahari Javan, and Behnoush Alizadeh

Subjects
Materials science, Alginates, Chemistry, Pharmaceutical, Polyesters, Dispersity, Pharmaceutical Science, Nanoparticle, Poloxamer, 02 engineering and technology, 030226 pharmacology & pharmacy, Injections, Nafarelin, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Differential scanning calorimetry, Glucuronic Acid, Polymer chemistry, medicine, Response surface methodology, Particle Size, Drug Carriers, Hexuronic Acids, General Medicine, 021001 nanoscience & nanotechnology, Chemical engineering, Delayed-Action Preparations, Poloxamer 407, Drug delivery, Nanoparticles, Particle size, 0210 nano-technology, Gels, medicine.drug
Abstract

The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin-poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin-loaded PHBV NPs were prepared via double emulsion solvent evaporation technique. Box-Behnken Response Surface Methodology was utilized to optimize NPs. Mean particle size, polydispersity index (PDI), entrapment efficiency (EE), and drug loading (DL) of the optimized NPs were measured. Incorporation of Nafarelin within NPs was proven by differential scanning calorimetry (DSC). The combination delivery system (CDS) was prepared by adding Nafarelin-loaded PHBV NPs to sodium alginate/poloxamer 407 solution followed by physical mixing. Morphological properties of Nafarelin-loaded PHBV NPs and CDS were evaluated by SEM. Rheological properties were employed to investigate the effects of alginate concentration on sol-gel transition temperature. The release profile of Nafarelin from both PHBV NPs and CDS were individually assessed. The cumulative release percentage from CDS was significantly lower than Nafarelin released from PHBV NPs. Based on the favorable results in this study, the CDS consisting of sodium alginate/poloxamer 407 loaded with PHBV NPs could be a promising candidate for designing a long-lasting formulation of Nafarelin.

Published
2017
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