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Purpose: To investigate the effect of training on scanning accuracy of complete arch scans (CAS) performed by first-time users, with a distinction made between specific training (repeated performance of CAS) and nonspecific training (simple use of an intraoral optical scanner for a sextant scan in the context of a CAD/ CAM teaching module). Materials and Methods: A total of 36 students with no experience in intraoral scanning were randomized into three groups (n = 12 per group) according to the number of CAS sessions: three sessions (3S), two sessions (2S), and one session (1S). Each student had to perform 10 CAS per scanning session. Sessions were scheduled at T0, T1, and T2 for group 3S; at T0 and T2 for group 2S; and at T2 for group 1S. Before the final scanning session in each group (ie, the first scanning session in group 1S), the students completed a CAD/CAM teaching module, which included fabrication of a monolithic crown in a fully digital chairside workflow. Results: In all groups, repeated CAS resulted in improved scanning accuracy. Participation in the CAD/CAM module had a positive effect on initial accuracy for CAS. Mean absolute deviations in cross-arch distance were 84 µm (T0), 68 µm (T1), and 63 µm (T2) for group 3S; 79 µm (T0) and 61 µm (T2) for group 2S; and 67 µm (T2) for group 1S. Conclusion: To perform CAS with the best possible accuracy, specific training is highly recommended. In addition, nonspecific training leads to an improvement in initial scanning accuracy. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the effect of training on scanning times of complete-arch scans (CAS) performed by first-time users, with a distinction made between specific training (repeated practice of CAS) and nonspecific training (simple use of an intraoral scanner for a sextant scan in the context of a student CAD/ CAM course). Methods: Thirty-six students with no experience in intraoral scanning were randomized into three groups (n = 12 per group) according to the number of specific CAS training sessions: three sessions (3S), two sessions (2S), and one session (1S). Each student performed 10 CAS per scanning session. These sessions were scheduled at baseline (T0), T1 (2 weeks after T0), and T2 (4 weeks after T0) for group 3S; at T0 and T2 for group 2S; and at T2 for group 1S. Before the final scanning session in each group (ie, the first scanning session in group 1S), the students participated in a CAD/CAM course (3 weeks after T0) in which a monolithic crown was fabricated in a fully digital chairside workflow. The scanning time was measured as the time between the activation and termination of the scanning mode of the intraoral device. Data were analyzed using SPSS Statistics 25 (IBM). The level of significance was set to α = .05. Results: A continual decrease in scanning time was observed for all groups as experience in intraoral scanning increased. The mean scanning times were as follows: for group 3S, 305 seconds at T0, 246 seconds at T1, and 233 seconds at T2; for group 2S, 380 seconds at T0 and 303 seconds at T2; and for group 1S, 355 seconds at T2. When compared to group 1S after it had received nonspecific training only, the effect of a single specific training session in groups 3S and 2S was not significant (P = .4428). However, two specific training sessions had a significant effect on scanning time compared to nonspecific training only (P = .0005). Conclusion: Training does affect the scanning time required for CAS. To perform such scans in a time-efficient manner, dental practitioners should undertake training that comprises at least 12 CAS. [ABSTRACT FROM AUTHOR]

Background: This randomized clinical trial was conducted to assess whether sleep bruxism (SB) is associated with an increased rate of technical complications (ceramic defects) in lithium disilicate (LiDi) or zirconia (Z) molar single crowns (SCs). Methods: Adult patients were classified as affected or unaffected by SB based on structured questionnaires, clinical signs, and overnight portable electromyography (BruxOff) and block randomized into four groups according to SB status and crown material (LiDi or Z): LiDi-SB (n = 29), LiDi-no SB (n = 24), Z-SB (n = 23), and Z-no SB (n = 27). Differences in technical complications (main outcome) and survival and success rates (secondary outcomes) one year after crown cementation were assessed using Fisher's exact test with significance level α = 0.05. Results: No technical complications occurred. Restoration survival rates were 100% in the LiDi-SB and LiDi-no SB groups, 95.7% in the Z-SB group, and 96.3% in the Z-no SB group (p > 0.999). Success rates were 96.6% in the LiDi-SB group, 95.8% in the LiDi-no SB group (p > 0.999), 91.3% in the Z-SB group, and 96.3% in the Z-no SB group (p ≥ 0.588). Conclusions: With a limited observation time and sample size, no effect of SB on technical complication, survival, and success rates of molar LiDi and Z SCs was detected. [ABSTRACT FROM AUTHOR]

Background: Reliable and suitable bruxism assessment would be desirable, but available studies presented heterogeneous results. Objective: To determine the agreement of patient self‐reports and clinical signs of sleep bruxism (SB) with electromyographic/electrocardiographic data. Methods: Two hundred individuals from a German dental clinic population (120 women and 80 men) participated in the study. Participants completed different SB questionnaires, had a clinical examination to evaluate bruxism signs and used the Bruxoff® device to record electromyographic/electrocardiographic data for five nights. To investigate interrater reliability for clinical diagnosis of bruxism, 126 of the 200 participants were assessed for clinical signs of bruxism by two independent uncalibrated examiners. Statistical evaluation included calculation of sensitivity, specificity and accuracy and of Cohen's kappa. Results: Based on the Bruxoff® data, 106 participants were identified as bruxers and 94 as non‐bruxers. The 106 bruxers were further classified into 47 moderate and 59 intense bruxers. The highest accuracy and sensitivity values were recorded for the overall score for clinical bruxism signs (accuracy: 72.0% and sensitivity: 70.8%). The best specificity (96.8%) was seen for the question regarding tooth grinding in the last two weeks reported by others, but concurrent sensitivity was very low (3.8%). Analysis of interrater reliability revealed a substantial agreement (Cohen's kappa of 0.6). Conclusion: The study results indicate that self‐report questionnaires and clinical signs have moderate sensitivity, specificity and accuracy for diagnosing bruxism comparing with an ambulatory device for current SB (Bruxoff®). Regarding interrater reliability for clinical signs of SB, substantial agreement was found between the two examiners. Clinical trial no. NCT03039985. [ABSTRACT FROM AUTHOR]

Background: Predictive models and assessment tools for disease susceptibility and progression are necessary to enhance personalized medicine. The aim of this study is to assess the predictive accuracy of using the 2018 classification to predict likelihood of tooth loss.Methods: A total of 134 patients were screened 10 years after periodontal therapy. Data were extracted from 82 patients' records and periodontal diagnoses were assigned according to the 1999 and 2018 classifications at baseline, whereas patient- and tooth-related parameters were documented at baseline and at reexamination. Statistical analysis included descriptive statistics, hurdle regression with a zero and count model as well as logistic regression.Results: Significantly more teeth were lost during SPT in patients with Stage IV or Grade C (P < 0.05). Patients' adherence seems to have an impact on the predictability of the 2018 classification (P < 0.001). In comparison, neither classification system alone (1999 vs 2018) showed a high predictive value for tooth loss (area under the curve [AUC] = 59.2% vs 58.2%).Conclusion: Class III and IV/Grade C of the 2018 classification of periodontal diseases show similar predictive accuracy for tooth loss as severe cases in the former classification. Patients adherence seems to influence the prognostic value of the classification. [ABSTRACT FROM AUTHOR]

Background Uraemic cardiac remodelling is associated with vitamin D and Klotho deficiency, elevated fibroblast growth factor 23 (FGF23) and activation of the renin–angiotensin system (RAS). The cardioprotective properties of active vitamin D analogues in this setting are unclear. Methods In rats with 5/6 nephrectomy (5/6Nx) treated with calcitriol, the cardiac phenotype and local RAS activation were investigated compared with controls. A nested case–control study was performed within the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study, including children with chronic kidney disease (CKD) Stages 3–5 [estimated glomerular filtration rate (eGFR) 25 mL/min/1.73 m2] treated with and without active vitamin D. Echocardiograms, plasma FGF23 and soluble Klotho (sKlotho) were assessed at baseline and after 9 months. Results In rats with 5/6Nx, left ventricular (LV) hypertrophy, LV fibrosis and upregulated cardiac RAS were dose-dependently attenuated by calcitriol. Calcitriol further stimulated FGF23 synthesis in bone but not in the heart, and normalized suppressed renal Klotho expression. In the 4C study cohort, treatment over a mean period of 9 months with active vitamin D was associated with increased FGF23 and phosphate and decreased sKlotho and eGFR compared with vitamin D naïve controls, whereas LV mass index did not differ between groups. Conclusions Active vitamin D ameliorates cardiac remodelling and normalizes renal Klotho expression in 5/6Nx rats but does not improve the cardiac phenotype in children with CKD Stages 3–5. This discrepancy may be due to further enhancement of circulating FGF23 and faster progression of CKD associated with reduced sKlotho and higher serum phosphate in vitamin D-treated patients. [ABSTRACT FROM AUTHOR]

Background: Infectious complications are a major cause of morbidity and mortality after kidney transplantation., Methods: In this transplant cohort study at the German Center of Infectious Diseases (DZIF), we evaluated all infections occurring during the first year after renal transplantation. We assessed microbial etiology, incidence rates, and temporal occurrence of these infections., Results: Of 804 renal transplant recipients (65.2% male, 51 ± 14 years), 439 (54.6%) had 972 infections within the first year after transplantation. Almost half of these infections (47.8%) occurred within the first 3 months. Bacteria were responsible for 66.4% (645/972) of all infections, followed by viral (28.9% [281/972]) and fungal (4.7% [46/972]) pathogens. The urinary tract was the most common site of infection (42.4%). Enterococcus was the most frequently isolated bacterium (20.9%), followed by E. coli (17.6%) and Klebsiella (12.5%). E. coli was the leading pathogen in recipients <50 years of age, whereas Enterococcus predominated in older recipients. Resistant bacteria were responsible for at least 1 infection in 9.5% (76/804) of all recipients. Viral infections occurred in 201 recipients (25.0%). Of these, herpes viruses predominated (140/281 [49.8%]), and cytomegalovirus had the highest incidence rate (12.3%). In the 46 fungal infections, Candida albicans (40.8%) was the most commonly isolated. Other fungal opportunistic pathogens, including Aspergillus fumigatus and Pneumocystis , were rare., Conclusions: Renal allograft recipients in Germany experience a high burden of infectious complications in the first year after transplantation. Bacteria were the predominating pathogen, followed by opportunistic infections such as cytomegalovirus. Microbial etiology varied between age groups, and resistant bacteria were identified in 10% of recipients., (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)