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7. OC69 SURGERY FOR BENTALL ENDOCARDITIS: SHORT AND LONG-TERM OUTCOME FROM A MULTI-CENTRE REGISTRY

Author

Sponga, S., Di Mauro, M., Pacini, D., Murara, G., Di Bartolomeo, R., Cappabianca, G., Beghi, C., Weltert, L., De Paulis, R., De Vincentiis, C., Biondi, A., Santini, F., Salsano, A., Salvador, L., Picichè, M., Mariscalco, G., Maselli, D., Rinaldi, M., Mancuso, S., Scrofani, R., Cagnoni, G., Antona, C., Dato, G.M.A., Centofani, P., De Bonis, M., Pozzoli, A., Cugola, D., Galletti, L., Villa, E., Dossena, Y., Troise, G., Barili, F., Paparella, D., Margari, V., Lorusso, R., Parolari, A., and Livi, U.

Published
2018
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8. OC71 SURGICAL TREATMENT FOR ISOLATED TRICUSPID VALVE INFECTIVE ENDOCARDITIS. 25-YEAR RESULTS

Author

Di Mauro, M., Dato, G. Actis, Barili, F., Corte, A. Della, Ratta, E. Della, Cugola, D., Galletti, L., Centofanti, P., Santini, F., Salsano, A., Rinaldi, M., Mancuso, S., Cappabianca, G., Beghi, C., De Vincentiis, C., Biondi, A., Livi, U., Sponga, S., Pacini, D., Murara, G., Di Bortalomeo, R., Scrofani, R., Cagnoni, G., Antona, C., Nicolini, F., Benassi, F., De Bonis, M., Pozzoli, A., Casali, G., Scrascia, G., Bortolotti, U., Falcetta, G., Musumeci, F., Gherli, R., Vizzardi, E., Salvador, L., Piccichè, M., Paparella, D., Margari, V., Troise, G., Villa, E., Dossena, Y., Lucarelli, C., Onorati, F., Faggian, G., Mariscalco, G., Maselli, D., Foschi, M., Parolari, A., and Lorusso, R.

Published
2018
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10. Incremental prognostic value of echocardiography of left ventricular remodeling and diastolic function in STICH trial

Author

Kim, K, She, L, Lee, K, Dabrowski, R, Grayburn, P, Rajda, M, Prior, D, Desvigne-Nickens, P, Zoghbi, W, Senni, M, Stefanelli, G, Beghi, C, Huynh, T, Velazquez, E, Oh, J, Lin, G, Kim KH, She L, Lee KL, Dabrowski R, Grayburn PA, Rajda M, Prior DL, Desvigne-Nickens P, Zoghbi WA, Senni M, Stefanelli G, Beghi C, Huynh T, Velazquez EJ, Oh JK, Lin G, Kim, K, She, L, Lee, K, Dabrowski, R, Grayburn, P, Rajda, M, Prior, D, Desvigne-Nickens, P, Zoghbi, W, Senni, M, Stefanelli, G, Beghi, C, Huynh, T, Velazquez, E, Oh, J, Lin, G, Kim KH, She L, Lee KL, Dabrowski R, Grayburn PA, Rajda M, Prior DL, Desvigne-Nickens P, Zoghbi WA, Senni M, Stefanelli G, Beghi C, Huynh T, Velazquez EJ, Oh JK, and Lin G

Abstract

Aims: We sought to determine which echocardiographic markers of left ventricular (LV) remodeling and diastolic dysfunction can contribute as incremental and independent prognostic information in addition to current clinical risk markers of ischemic LV systolic dysfunction in the Surgical Treatment for Ischemic Heart Failure (STICH) trial. Methods and results: The cohort consisted of 1511 of 2136 patients in STICH for whom baseline transmitral Doppler (E/A ratio) could be measured by an echocardiographic core laboratory blinded to treatment and outcomes, and prognostic value of echocardiographic variables was determined by a Cox regression model. E/A ratio was the most significant predictor of mortality amongst diastolic variables with lowest mortality for E/A closest 0.8, although mortality was consistently low for E/A 0.6 to 1.0. Mortality increased for E/A < 0.6 and > 1.0 up to approximately 2.3, beyond which there was no further increase in risk. Larger LV end-systolic volume index (LVESVI) and E/A < 0.6 and > 1.0 had incremental negative effects on mortality when added to a clinical multivariable model, where creatinine, LVESVI, age, and E/A ratio accounted for 74% of the prognostic information for predicting risk. LVESVI and E/A ratio were stronger predictors of prognosis than New York Heart Association functional class, anemia, diabetes, history of atrial fibrillation, and stroke. Conclusions: Echocardiographic markers of advanced LV remodeling and diastolic dysfunction added incremental prognostic value to current clinical risk markers. LVESVI and E/A ratio outperformed other markers and should be considered as standard in assessing risks in ischemic heart failure. E/A closest to 0.8 was the most optimal filling pattern.

Published
2020

11. Surgical treatment of isolated tricuspid valve infective endocarditis: 25-year results from a multicenter registry

Author

Di Mauro, M, Foschi, M, Dato, G, Centofanti, P, Barili, F, Corte, A, Ratta, E, Cugola, D, Galletti, L, Santini, F, Salsano, A, Rinaldi, M, Mancuso, S, Cappabianca, G, Beghi, C, De Vincentiis, C, Biondi, A, Livi, U, Sponga, S, Pacini, D, Murana, G, Scrofani, R, Antona, C, Cagnoni, G, Nicolini, F, Benassi, F, De Bonis, M, Pozzoli, A, Casali, G, Scrascia, G, Falcetta, G, Bortolotti, U, Musumeci, F, Gherli, R, Vizzardi, E, Salvador, L, Piciche, M, Paparella, D, Margari, V, Troise, G, Villa, E, Dossena, Y, Lucarelli, C, Onorati, F, Faggian, G, Mariscalco, G, Maselli, D, Parolari, A, Lorusso, R, Di Mauro M., Foschi M., Dato G. M. A., Centofanti P., Barili F., Corte A. D., Ratta E. D., Cugola D., Galletti L., Santini F., Salsano A., Rinaldi M., Mancuso S., Cappabianca G., Beghi C., De Vincentiis C., Biondi A., Livi U., Sponga S., Pacini D., Murana G., Scrofani R., Antona C., Cagnoni G., Nicolini F., Benassi F., De Bonis M., Pozzoli A., Casali G., Scrascia G., Falcetta G., Bortolotti U., Musumeci F., Gherli R., Vizzardi E., Salvador L., Piciche M., Paparella D., Margari V., Troise G., Villa E., Dossena Y., Lucarelli C., Onorati F., Faggian G., Mariscalco G., Maselli D., Parolari A., Lorusso R., Di Mauro, M, Foschi, M, Dato, G, Centofanti, P, Barili, F, Corte, A, Ratta, E, Cugola, D, Galletti, L, Santini, F, Salsano, A, Rinaldi, M, Mancuso, S, Cappabianca, G, Beghi, C, De Vincentiis, C, Biondi, A, Livi, U, Sponga, S, Pacini, D, Murana, G, Scrofani, R, Antona, C, Cagnoni, G, Nicolini, F, Benassi, F, De Bonis, M, Pozzoli, A, Casali, G, Scrascia, G, Falcetta, G, Bortolotti, U, Musumeci, F, Gherli, R, Vizzardi, E, Salvador, L, Piciche, M, Paparella, D, Margari, V, Troise, G, Villa, E, Dossena, Y, Lucarelli, C, Onorati, F, Faggian, G, Mariscalco, G, Maselli, D, Parolari, A, Lorusso, R, Di Mauro M., Foschi M., Dato G. M. A., Centofanti P., Barili F., Corte A. D., Ratta E. D., Cugola D., Galletti L., Santini F., Salsano A., Rinaldi M., Mancuso S., Cappabianca G., Beghi C., De Vincentiis C., Biondi A., Livi U., Sponga S., Pacini D., Murana G., Scrofani R., Antona C., Cagnoni G., Nicolini F., Benassi F., De Bonis M., Pozzoli A., Casali G., Scrascia G., Falcetta G., Bortolotti U., Musumeci F., Gherli R., Vizzardi E., Salvador L., Piciche M., Paparella D., Margari V., Troise G., Villa E., Dossena Y., Lucarelli C., Onorati F., Faggian G., Mariscalco G., Maselli D., Parolari A., and Lorusso R.

Abstract

Background: To assess early and late mortality in patients with isolated acute tricuspid valve infective endocarditis (TVIE) using data from a multicenter registry. Methods: From 1983 to 2018, isolated acute TVIE was surgically treated in 157 (3.8%) patients [mean age 47 ± 16 years (range 15–86 years), 25% females]. Of these, 142 (90%) had native tricuspid regurgitation, 7 (5%) native tricuspid valve (TV) steno-regurgitation, and 8 (5%) prosthetic TVIE. Intravenous drug use (IVDU) was recorded in 38% of patients, infection involved cardiac implantable electronic device leads in 21%, and vascular catheters for dialysis in 1%; in the remaining cases, the cause was unknown. The primary endpoint was in-hospital outcome, long-term freedom from recurrence and overall survival. Results: Overall, 77 (49%) patients underwent TV repair, 72 (46%) TV replacement, and 8 (5%) prosthetic TV replacement. Early mortality was 11% (n = 17). Expected early mortality according to EndoSCORE was 12%, with age (odds ratio 1.06) and redo (odds ratio 6.64) as risk factors. Late deaths occurred in 31 patients and TVIE recurrences in 4. Survival rates at 10, 20, and 25 years were 66%, 60%, and 44%, respectively. Risk factors were age [hazard ratio (HR) 1.06], mycotic TVIE (HR 4.2), IVDU (HR 4.90), infected prosthesis replacement (HR 4.4), and presence of cardiac implantable electronic device leads (HR 3.0). No significant difference was found in valve repair vs. replacement and in IVDUs vs. non-IVDUs. Conclusions: Patients with isolated acute TVIE undergoing surgical treatment show acceptable early and late outcomes. TVIE recurrence was low, and repair of the affected valve does not seem to confer any advantage either at early or long term up to 25 years.

Published
2019

14. Corrigendum to “A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE”. [Int. J. Cardiol. 241 (Aug 15 2017) 97–102](S0167527317309877)(10.1016/j.ijcard.2017.03.148)

Author

Di Mauro M., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, Demartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sponga S., Pacini D., Di Bartolomeo R., DeMartino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., Nappi G., Di Mauro M., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, Demartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sponga S., Pacini D., Di Bartolomeo R., DeMartino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., and Nappi G.

Abstract

The authors regret that the first name and last name of the author Sandro Sponga was published incorrectly in the original version and this has now been corrected.

Published
2018

16. Incremental prognostic value of echocardiography of left ventricular remodeling and diastolic function in STICH trial.

Author

Kim, K-H, She, L, Lee, KL, Dabrowski, R, Grayburn, PA, Rajda, M, Prior, DL, Desvigne-Nickens, P, Zoghbi, WA, Senni, M, Stefanelli, G, Beghi, C, Huynh, T, Velazquez, EJ, Oh, JK, Lin, G, Kim, K-H, She, L, Lee, KL, Dabrowski, R, Grayburn, PA, Rajda, M, Prior, DL, Desvigne-Nickens, P, Zoghbi, WA, Senni, M, Stefanelli, G, Beghi, C, Huynh, T, Velazquez, EJ, Oh, JK, and Lin, G

Abstract

AIMS: We sought to determine which echocardiographic markers of left ventricular (LV) remodeling and diastolic dysfunction can contribute as incremental and independent prognostic information in addition to current clinical risk markers of ischemic LV systolic dysfunction in the Surgical Treatment for Ischemic Heart Failure (STICH) trial. METHODS AND RESULTS: The cohort consisted of 1511 of 2136 patients in STICH for whom baseline transmitral Doppler (E/A ratio) could be measured by an echocardiographic core laboratory blinded to treatment and outcomes, and prognostic value of echocardiographic variables was determined by a Cox regression model. E/A ratio was the most significant predictor of mortality amongst diastolic variables with lowest mortality for E/A closest 0.8, although mortality was consistently low for E/A 0.6 to 1.0. Mortality increased for E/A < 0.6 and > 1.0 up to approximately 2.3, beyond which there was no further increase in risk. Larger LV end-systolic volume index (LVESVI) and E/A < 0.6 and > 1.0 had incremental negative effects on mortality when added to a clinical multivariable model, where creatinine, LVESVI, age, and E/A ratio accounted for 74% of the prognostic information for predicting risk. LVESVI and E/A ratio were stronger predictors of prognosis than New York Heart Association functional class, anemia, diabetes, history of atrial fibrillation, and stroke. CONCLUSIONS: Echocardiographic markers of advanced LV remodeling and diastolic dysfunction added incremental prognostic value to current clinical risk markers. LVESVI and E/A ratio outperformed other markers and should be considered as standard in assessing risks in ischemic heart failure. E/A closest to 0.8 was the most optimal filling pattern.

Published
2020

19. Surgery for prosthetic valve endocarditis: A retrospective study of a national registry

Author

Corte, A, Di Mauro, M, Dato, G, Barili, F, Cugola, D, Gelsomino, S, Sante, P, Carozza, A, Ratta, E, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Pacini, D, Di Bartolomeo, R, De Martino, A, Bortolotti, U, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Parolari, A, Nappi, G, Corte A. D., Di Mauro M., Dato G. A., Barili F., Cugola D., Gelsomino S., Sante P., Carozza A., Ratta E. D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Pacini D., Di Bartolomeo R., De Martino A., Bortolotti U., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Parolari A., Nappi G., Corte, A, Di Mauro, M, Dato, G, Barili, F, Cugola, D, Gelsomino, S, Sante, P, Carozza, A, Ratta, E, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Pacini, D, Di Bartolomeo, R, De Martino, A, Bortolotti, U, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Parolari, A, Nappi, G, Corte A. D., Di Mauro M., Dato G. A., Barili F., Cugola D., Gelsomino S., Sante P., Carozza A., Ratta E. D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Pacini D., Di Bartolomeo R., De Martino A., Bortolotti U., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Parolari A., and Nappi G.

Abstract

OBJECTIVES: We described clinical-epidemiological features of prosthetic valve endocarditis (PVE) and assessed the determinants of early surgical outcomes in multicentre design. METHODS: Data regarding 2823 patients undergoing surgery for endocarditis at 19 Italian Centers between 1979 and 2015 were collected in a database. Of them, 582 had PVE: in this group, the determinants of early mortality and complications were assessed, also taking into account the different chronological eras encompassed by the study. RESULTS: Overall hospital (30-day) mortality was 19.2% (112 patients). Postoperative complications of any type occurred in 256 patients (44%). Across 3 eras (1980-2000, 2001-08 and 2009-14), early mortality did not significantly change (20.4%, 17.1%, 20.5%, respectively, P = 0.60), whereas complication rate increased (18.5%, 38.2%, 52.8%, P < 0.001), consistent with increasing mean patient age (56 ± 14, 64 ± 15, 65 ± 14 years, respectively, P < 0.001) and median logistic EuroSCORE (14%, 21%, 23%, P = 0.025). Older age, female sex, preoperative serum creatinine > -2 mg/dl, chronic pulmonary disease, low ejection fraction, non-streptococcal aetiology, active endocarditis, preoperative intubation, preoperative shock and triple valve surgery were significantly associated with mortality. In multivariable analysis, age (OR = 1.02; P = 0.03), renal insufficiency (OR = 2.1; P = 0.05), triple valve surgery (OR = 6.9; P = 0.004) and shock (OR = 4.5; P < 0.001) were independently associated with mortality, while streptococcal aetiology, healed endocarditis and ejection fraction with survival. Adjusting for study era, preoperative shock (OR = 3; P < 0.001), Enterococcus (OR = 2.3; P = 0.01) and female sex (OR = 1.5; P = 0.03) independently predicted complications, whereas ejection fraction was protective. CONCLUSIONS: PVE surgery remains a high-risk one. The strongest predictors of early outcome of PVE surgery are related to patient's haemodynamic status an

Published
2017

20. A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE

Author

Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sandro, S, Pacini, D, Di Bartolomeo, R, De Martino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sandro S., Pacini D., Di Bartolomeo R., De Martino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., Nappi G., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sandro, S, Pacini, D, Di Bartolomeo, R, De Martino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sandro S., Pacini D., Di Bartolomeo R., De Martino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., and Nappi G.

Abstract

Background The aim of this large retrospective study was to provide a logistic risk model along an additive score to predict early mortality after surgical treatment of patients with heart valve or prosthesis infective endocarditis (IE). Methods From 2000 to 2015, 2715 patients with native valve endocarditis (NVE) or prosthesis valve endocarditis (PVE) were operated on in 26 Italian Cardiac Surgery Centers. The relationship between early mortality and covariates was evaluated with logistic mixed effect models. Fixed effects are parameters associated with the entire population or with certain repeatable levels of experimental factors, while random effects are associated with individual experimental units (centers). Results Early mortality was 11.0% (298/2715); At mixed effect logistic regression the following variables were found associated with early mortality: age class, female gender, LVEF, preoperative shock, COPD, creatinine value above 2 mg/dl, presence of abscess, number of treated valve/prosthesis (with respect to one treated valve/prosthesis) and the isolation of Staphylococcus aureus, Fungus spp., Pseudomonas Aeruginosa and other micro-organisms, while Streptococcus spp., Enterococcus spp. and other Staphylococci did not affect early mortality, as well as no micro-organisms isolation. LVEF was found linearly associated with outcomes while non-linear association between mortality and age was tested and the best model was found with a categorization into four classes (AUC = 0.851). Conclusions The following study provides a logistic risk model to predict early mortality in patients with heart valve or prosthesis infective endocarditis undergoing surgical treatment, called “The EndoSCORE”.

Published
2017

21. Recurrence of a right ventricular hemangioma

Author

Colli, A., Budillon, A. M., DeCicco, G., Agostinelli, A., Nicolini, F., Tzialtas, D., Zoffoli, G., Corradi, D., Maestri, R., Beghi, C., and Gherli, T.

Published
2003

22. RF67 REDO MITRAL SURGERY AND HOSPITAL OUTCOME

Author

Franzese, I., Biagio, L. San, Perrotti, A., Mariscalco, G., Francica, A., Lucarelli, C., De Feo, M., Santarpino, G., Salsano, A., Rubino, A., Gatti, G., Beghi, C., Mignosa, C., Pappalardo, A., Onorati, F., Santini, F., and Faggian, G.

Published
2018

23. OC62 REDO MITRAL SURGERY AND HOSPITAL OUTCOME

Author

Franzese, I., Biagio, L. San, Gatti, G., Perrotti, A., Mariscalco, G., Milano, A. D., De Feo, M., Rubino, A., Santarpino, G., Salsano, A., Lucarelli, C., Francica, A., Beghi, C., Mignosa, C., Pappalardo, A., D’Errigo, P., Santini, F., Onorati, F., and Faggian, G.

Published
2018

24. OC69 SURGERY FOR BENTALL ENDOCARDITIS

Author

Sponga, S., Di Mauro, M., Pacini, D., Murara, G., Di Bartolomeo, R., Cappabianca, G., Beghi, C., Weltert, L., De Paulis, R., De Vincentiis, C., Biondi, A., Santini, F., Salsano, A., Salvador, L., Picichè, M., Mariscalco, G., Maselli, D., Rinaldi, M., Mancuso, S., Scrofani, R., Cagnoni, G., Antona, C., Dato, G. M. A., Centofani, P., De Bonis, M., Pozzoli, A., Cugola, D., Galletti, L., Villa, E., Dossena, Y., Troise, G., Barili, F., Paparella, D., Margari, V., Lorusso, R., Parolari, A., and Livi, U.

Published
2018

26. Corrigendum to “A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE”. [Int. J. Cardiol. 241 (Aug 15 2017) 97–102](S0167527317309877)(10.1016/j.ijcard.2017.03.148)

Author

Di Mauro, M, Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, DeMartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro, M, Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, DeMartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, and Nappi, G

Abstract

The authors regret that the first name and last name of the author Sandro Sponga was published incorrectly in the original version and this has now been corrected.

Published
2018

27. St. Jude Medical Trifecta aortic valve: Results from a prospective regional multicentre registry

Author

Mariscalco, G, Mariani, S, Bichi, S, Biondi, A, Blasio, A, Borsani, P, Corti, F, De Chiara, B, Gherli, R, Leva, C, Russo, C, Tasca, G, Vanelli, P, Alfieri, O, Antona, C, Di Credico, G, Esposito, G, Gamba, A, Martinelli, L, Menicanti, L, Paolini, G, Beghi, C, Mariscalco G., Mariani S., Bichi S., Biondi A., Blasio A., Borsani P., Corti F., De Chiara B., Gherli R., Leva C., Russo C. F., Tasca G., Vanelli P., Alfieri O., Antona C., Di Credico G., Esposito G., Gamba A., Martinelli L., Menicanti L., Paolini G., Beghi C., Mariscalco, G, Mariani, S, Bichi, S, Biondi, A, Blasio, A, Borsani, P, Corti, F, De Chiara, B, Gherli, R, Leva, C, Russo, C, Tasca, G, Vanelli, P, Alfieri, O, Antona, C, Di Credico, G, Esposito, G, Gamba, A, Martinelli, L, Menicanti, L, Paolini, G, Beghi, C, Mariscalco G., Mariani S., Bichi S., Biondi A., Blasio A., Borsani P., Corti F., De Chiara B., Gherli R., Leva C., Russo C. F., Tasca G., Vanelli P., Alfieri O., Antona C., Di Credico G., Esposito G., Gamba A., Martinelli L., Menicanti L., Paolini G., and Beghi C.

Abstract

Background: The Trifecta aortic bioprosthesis (St. Jude Medical, Inc., St. Paul, MN, USA) is a stented pericardial heart valve with excellent preliminary results. Aim of the study was to evaluate its early clinical and hemodynamic performances in a multicenter regional registry. Methods: Between January 2011 and June 2012, 178 consecutive patients undergoing aortic valve replacement with the Trifecta bioprosthesis were prospectively enrolled at 9 Italian centers. Clinical and echocardiographic data were collectedat discharge, 6-months and at 1-year postoperatively. Results: The average age was 75.4 ± 7.7years,and 95 (53%) were men. Indication for valve replacement included stenosis in 123 patients (69%), mixed lesions in 25 (14%), and regurgitation in 30 (17%). Ninety-three (52%) patients were in NYHA functional class III/ IV. Hospital mortality accounted for 5 (2.8%) patients. No valve-related perioperative complications were encountered. Median follow-up was 20.5months (range: 1-34). Early (≤6months) complications included one thromboembolic event, one major bleeding, and 3 endocarditis (2 explants). Two late (>6months) thromboembolic events and two endocarditis (1 explant) were registered. No valve thrombosis or structural deterioration were observed after discharge. At 30-months, freedom from all-cause mortality was 87%, freedom from valve-related mortality 99.4%, freedom from endocarditis 97.5%, and freedom from valve explants 98%. At 1-year, mean gradients ranged from 8 to 16mmHg, and effective orifice area indexes from 1.0 to 1.2cm2/m2 for valve sizes from 19 to27 mm, respectively. No patients had severe prosthesis-patient mismatch. Conclusions: Trifecta bioprosthesis provided favourable clinical and hemodynamic results over time.

Published
2015

28. Innate and adaptive immunity in human epilepsies

Author

Bauer, J., Becker, A. (Albert), Elyaman, W. (Wassim), Peltola, J. (Jukka), Rüegg, S. (Stephan), Titulaer, M.J. (Maarten), Varley, J.A. (James A.), Beghi, C. (Cesare), Bauer, J., Becker, A. (Albert), Elyaman, W. (Wassim), Peltola, J. (Jukka), Rüegg, S. (Stephan), Titulaer, M.J. (Maarten), Varley, J.A. (James A.), and Beghi, C. (Cesare)

Abstract

Inflammatory mechanisms have been increasingly implicated in the origin of seizures and epilepsy. These mechanisms are involved in the genesis of encephalitides in which seizures are a common complaint. Experimental and clinical evidence suggests different inflammatory responses in the brains of patients with epilepsy depending on the etiology. In general, activation of both innate and adaptive immunity plays a role in refractory forms of epilepsy. Epilepsies in which seizures develop after infiltration of cells of the adaptive immune system in the central nervous system (CNS) include a broad range of epileptic disorders with different (known or unknown) etiologies. Infiltration of lymphocytes is observed in autoimmune epilepsies, especially the classical paraneoplastic encephalitides with antibodies against intracellular tumor antigens. The presence of lymphocytes in the CNS also has been found in focal cerebral dysplasia type 2 and in cortical tubers. Various autoantibodies have been shown to be associated with temporal lobe epilepsy (TLE) and hippocampal sclerosis of unknown etiology, which may be due to the presence of viral DNA. During the last decade, an increasing number of antineuronal autoantibodies directed against membranous epitopes have been discovered and are associated with various neurologic syndromes, including limbic encephalitis. A major challenge in epilepsy is to define biomarkers, which would allow the recognition of patient populations who might benefit from immune-modulatory therapies. Some peripheral inflammatory markers appear to be differentially expressed in patients with medically controlled and medica

Published
2017
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29. Veno-arterial ECMO for fulminant myocarditis in adult patients: a multi-institutional experience

Author

Lorusso, R., Centofanti, P., Russo, C., Gelsomino, S., Botta, L., Actis Dato, M., Casabona, R., Martinelli, L., Casali, G., Musumeci, F., Pappalardo, F., De Bonis, M., Zangrillo, A., Alfieri, O., Pellegrini, C., Mazzola, S., Coletti, G., Vizzardi, Enrico, Bianco, R., Gerosa, G., Massetti, M., Caldaroni, F., Pilato, E., Pacini, D., Di Bartolomeo, R., Mariscalco, G., Beghi, C., Miceli, A., Glauber, M., Sponga, S., Livi, U., Rinaldi, M., Lorusso, R., Centofanti, P., Russo, C., Gelsomino, S., Botta, L., Actis Dato, M., Casabona, R., Martinelli, L., Casali, G., Musumeci, F., Pappalardo, F., De Bonis, M., Zangrillo, A., Alfieri, O., Pellegrini, C., Mazzola, S., Coletti, G., Vizzardi, E., Bianco, R., Gerosa, G., Massetti, M., Caldaroni, F., Pilato, E., Pacini, D., Di Bartolomeo, R., Mariscalco, G., Beghi, C., Miceli, A., Glauber, M., Sponga, S., Livi, U., and Rinaldi., M.

Published
2014

30. Non invasive imaging of coronary arteries with 64-slice CT and 1.5T MRI: challenging invasive techniques

Author

Cademartiri, F., Palumbo, A. A., Erica Maffei, La Grutta, L., Casolo, G., Aldrovandi, A., Reverberi, C., Brambilla, V., Coruzzi, P., Beghi, C., Ardissino, D., Crist, G., Zompatori, M., CADEMARTIRI F, PALUMBO AA, MAFFEI E, LA GRUTTA L, CASOLO G, ALDROVANDI A, REVERBERI C, BRAMBILLA V, CORUZZI P, BEGHI C, ARDISSINO D, CRISI G, ZOMPATORI M., Cademartiri,F, Palumbo,AA, Maffei,E, La Grutta,L, Casolo,G, Aldrovandi,A, Reverberi,C, Brambilla,V, Coruzzi,P, Beghi,C, Ardissino,D, Crisi,G, and Zompatori,M

Subjects
Humans, Coronary atherosclerosis, plaque, coronary imaging, Multislice CT, 64-slice CT, Magnetic Resonance, Coronary Artery Disease, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, Tomography, X-Ray Computed, Magnetic Resonance Imaging
Abstract

Non-invasive coronary artery imaging challenges any diagnostic modality, because of the complex and tortuous anatomy and cardiac contraction and respiration. Therefore, non-invasive coronary imaging requires high spatial and temporal resolution. Our purpose is to discuss the feasible applications in coronary imaging of Magnetic Resonance Imaging and Multi-slice Computed Tomography (MSCT). Focus will be devoted to potential indications and clinical impact of MSCT because of the fast development and the important results recently reported, in particular with the recent introduction of 64-slice equipments. MSCT of the coronary arteries is a promising imaging modality for the assessment of coronary lumen and wall.

Published
2007

33. PACEMAKER DEPENDENCY FOLLOWING CARDIAC SURGERY PROCEDURES: A COMPREHENSIVE LONG-TERM POSTOPERATIVE EVALUATION OF 1158 INHOSPITAL IMPLANTS FROM A MULTICENTER ITALIAN EXPERIENCE

Author

Lorusso, R., Barili, F., Miceli, A., Parolari, A., Daprati, A., Myasoedova, V., Alamanni, F., De Vincentiis, C., Grimaldi, F., Aimè, E., Gonzi, G. L., Gherli, T., Colli, A., Gerosa, G., De Bonis, M., Pozzoli, A., Paglino, G., Della Bella, P., Actis Dato, G., Varone, E., Parisi, F., Casabona, R., Sponga, S., Toniolo, M., Proclemer, A., Livi, U., Mariscalco, G., Scannapieco, A., Beghi, C., Scrofani, R., Foresti, D., Antona, C., Tritto, F., Gregorio, R., Miraglia, M., Piazza, L., Villa, E., Dalla Tomba, M., Pecora, D., Troise, G., Serraino, F., Renzulli, A., Rosato, F., Grasso, E., Grossi, C., Paparella, D., Amorese, L., de Luca Tupputi Schinosa, L., Coletti, G., Curnis, Antonio, Vizzardi, Enrico, and Glauber, M.

Published
2014

34. Risk Factors and Complications Affecting Hospital Outcome after Redo Mitral Surgery

Author

Onorati, F., primary, Reichart, D., additional, Perrotti, A., additional, Mariscalo, G., additional, Della Ratta, E., additional, Santarpino, G., additional, Salsano, A., additional, Rubino, A., additional, Biancari, F., additional, Beghi, C., additional, De Feo, M., additional, Mignosa, C., additional, Fischlein, T., additional, Chocron, S., additional, Detter, C., additional, Santini, F., additional, Reichenspurner, H., additional, and Faggian, G., additional

Published
2016
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35. THE USE OF MAGNETIC RESONANCE IN MYOCARDIAL ISCHAEMIA

Author

Massimo DE FILIPPO, Sudberry, J. J., Borgia, D., Rovani, C., Chernyschova, N., Salati, F., Cagnoni, G., Blasi, M., Beghi, C., Zompatori, M., DE FILIPPO M., SUDBERRY J.J., BORGIA D., ROVANI C., CHERNYSCHOVA N., SALATI F., CAGNONI G., DE BLASI M., BEGHI C., and ZOMPATORI M.

Subjects
medical assessment, nuclear magnetic resonance, heart muscle ischemia, heart muscle perfusion, allopathy, blood flow, coronary artery, heart infarction, heart volume, intermethod comparison, kinetics, medical examination
Published
2005

37. Venoarterial Extracorporeal Membrane Oxygenation for Acute Fulminant Myocarditis in Adult Patients: A 5-Year Multi-Institutional Experience

Author

Lorusso, R, Centofanti, P, Gelsomino, S, Barili, F, Di Mauro, M, Orlando, P, Botta, L, Milazzo, F, Actis Dato, G, Casabona, R, Casali, G, Musumeci, F, De Bonis, M, Zangrillo, A, Alfieri, O, Pellegrini, C, Mazzola, S, Coletti, G, Vizzardi, E, Bianco, R, Gerosa, G, Massetti, Massimo, Caldaroni, F, Pilato, E, Pacini, D, Di Bartolomeo, R, Marinelli, G, Sponga, S, Livi, U, Mauro, R, Mariscalco, G, Beghi, C, Miceli, A, Glauber, M, Pappalardo, F, Russo, Cf, Massetti, Massimo (ORCID:0000-0002-7100-8478), Lorusso, R, Centofanti, P, Gelsomino, S, Barili, F, Di Mauro, M, Orlando, P, Botta, L, Milazzo, F, Actis Dato, G, Casabona, R, Casali, G, Musumeci, F, De Bonis, M, Zangrillo, A, Alfieri, O, Pellegrini, C, Mazzola, S, Coletti, G, Vizzardi, E, Bianco, R, Gerosa, G, Massetti, Massimo, Caldaroni, F, Pilato, E, Pacini, D, Di Bartolomeo, R, Marinelli, G, Sponga, S, Livi, U, Mauro, R, Mariscalco, G, Beghi, C, Miceli, A, Glauber, M, Pappalardo, F, Russo, Cf, and Massetti, Massimo (ORCID:0000-0002-7100-8478)

Abstract

Acute fulminant myocarditis (AFM) may represent a life-threatening event, characterized by rapidly progressive cardiac compromise that ultimately leads to refractory cardiogenic shock or cardiac arrest. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides effective cardiocirculatory support in this circumstance, but few clinical series are available about early and long-term results. Data from a multicenter study group are reported which analyzed subjects affected by AFM and treated with VA-ECMO during a 5-year period.

Published
2015

40. Aortic valve replacement in octogenarians: analysis of risk factors for early and late mortality

Author

Nicolini, F., Beghi, C., Barbieri, F., Piercesare Secchi, Agostinelli, A., Fragnito, C., Spaggiari, I., and Gherli, T.

Subjects
Aged, 80 and over, Heart Valve Prosthesis Implantation, Male, Survival Rate, Risk Factors, Aortic Valve, Age Factors, Humans, Female, Aortic Valve Stenosis, Hospital Mortality, Follow-Up Studies, Retrospective Studies
Abstract

Cardiac surgery can be performed on elderly patients in good physical and mental health, thus improving their mortality, morbidity, and quality of life. Nevertheless, for some elderly patients aortic valve replacement (AVR) is still denied because of the presence of preoperative characteristics, such as older age and left ventricular dysfunction. The study aim was to review early and long-term results in patients agedor = 80 years who underwent AVR for severe aortic stenosis, and to identify risk factors for in-hospital and late mortality.A total of 165 patients (mean age 82 +/- 2.1 years) underwent AVR for severe aortic stenosis, with or without concomitant coronary revascularization, at the authors' institution. The mean aortic valve area was 0.61 +/- 0.2 cm2. Preoperatively, 20 patients (12%) had a left ventricular ejection fraction35%. The mean EuroSCORE was 9.45 +/- 1.52.Seven patients (4%) experienced low cardiac output syndrome, and acute renal failure occurred in 24. No perioperative myocardial infarction, stroke or sternal wound infection was detected. In total, 23 patients (14%) required prolonged ventilatory support. The in-hospital mortality was 3%. After a mean follow up of 43 +/- 35.6 months there were 18 late deaths: the cardiac-related mortality was 7%. The mean NYHA class was improved from 2.86 +/- 0.67 to 1.44 +/- 0.57 (p0.0001).Conventional AVR remains the standard of care, and can be performed with satisfactory in-hospital mortality, long-term life expectancy and quality of life in high-risk elderly patients. Although the transcatheter aortic valve technique seems to be a promising option, its long-term value must be established in prospective, randomized trials.

Published
2010

48. Mid-term results of aortic valve surgery in redo scenarios in the current practice: results from the multicentre European RECORD (REdo Cardiac Operation Research Database) initiative

Author

Onorati, F., primary, Biancari, F., additional, De Feo, M., additional, Mariscalco, G., additional, Messina, A., additional, Santarpino, G., additional, Santini, F., additional, Beghi, C., additional, Nappi, G., additional, Troise, G., additional, Fischlein, T., additional, Passerone, G., additional, Heikkinen, J., additional, and Faggian, G., additional

Published
2014
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49. Outcome of redo surgical aortic valve replacement in patients aged more than 80 years: Results from the multicenter RECORD initiative

Author

Santarpino, G., primary, Onorati, F., additional, Biancari, F., additional, Mariscalco, G., additional, De Feo, M., additional, Messina, A., additional, Santini, F., additional, Beghi, C., additional, Nappi, G., additional, Troise, G., additional, Passerone, G., additional, Heikkinen, J., additional, Faggian, G., additional, and Fischlein, T., additional

Published
2014
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50. Incidence and determinants of stroke after surgical aortic valve replacement in patients with prior cardiac surgery: Results from the multicenter RECORD initiative

Author

Santarpino, G., primary, Biancari, F., additional, Onorati, F., additional, Mariscalco, G., additional, De Feo, M., additional, Messina, A., additional, Santini, F., additional, Beghi, C., additional, Nappi, G., additional, Troise, G., additional, Passerone, G., additional, Heikkinen, J., additional, Faggian, G., additional, and Fischlein, T., additional

Published
2014
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