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2. Identification and characterization of calcium binding protein, spermatid-associated 1 (CABS1)# in selected human tissues and fluids.

Author

Reyes-Serratos, Eduardo, Ramielle L. Santos, Joy, Puttagunta, Lakshmi, Lewis, Stephen J., Watanabe, Mechiko, Gonshor, Aron, Buck, Robert, Befus, A. Dean, and Marcet-Palacios, Marcelo

Subjects
SALIVARY glands, SPERMATOGENESIS, CARRIER proteins, SALIVARY proteins, SERTOLI cells, LEYDIG cells, CYTOSKELETAL proteins
Abstract

Calcium binding protein, spermatid associated 1 (CABS1) is a protein most widely studied in spermatogenesis. However, mRNA for CABS1 has been found in numerous tissues, albeit with little information about the protein. Previously, we identified CABS1 mRNA and protein in human salivary glands and provided evidence that in humans CABS1 contains a heptapeptide near its carboxyl terminus that has anti-inflammatory activities. Moreover, levels of an immunoreactive form of CABS1 were elevated in psychological stress. To more fully characterize human CABS1 we developed additional polyclonal and monoclonal antibodies to different sections of the protein and used these antibodies to characterize CABS1 in an overexpression cell lysate, human salivary glands, saliva, serum and testes using western blot, immunohistochemistry and bioinformatics approaches exploiting the Gene Expression Omnibus (GEO) database. CABS1 appears to have multiple molecular weight forms, consistent with its recognition as a structurally disordered protein, a protein with structural plasticity. Interestingly, in human testes, its cellular distribution differs from that in rodents and pigs, and includes Leydig cells, primary spermatogonia, Sertoli cells and developing spermatocytes and spermatids, Geodata suggests that CABS1 is much more widely distributed than previously recognized, including in the urogenital, gastrointestinal and respiratory tracts, as well as in the nervous system, immune system and other tissues. Much remains to be learned about this intriguing protein. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study

Author

Daley, Denise, Silverman, Frances, Hayglass, Kent, Kobor, Michael, Turvey, Stuart, Kollmann, Tobias, Brook, Jeff, Ramsey, Clare, Macri, Joseph, Sandford, Andrew, Pare, Peter, Tebbutt, Scott, Brauer, Michael, Denburg, Judah, Cyr, Michael, Kozyrskyj, Anita, Becker, Allan, Chen, Edith, Miller, Greg, Takaro, Tim, Ratjen, Felix, Grasemann, Hartmut, Dell, Sharon, To, Teresa, Moraes, Theo, Subbarao, Padmaja, Holness, Linn, Befus, A. Dean, Mandhane, Piushkumar, Laprise, Catherine, Scott, James, Hegele, Richard, Lou, Wendy, Anand, Sonia, Sears, Malcolm, Simons, Elinor, Azad, Meghan, Eiwegger, Thomas, Duan, Qingling, Hystad, Perry, Scott, Jeremy, Klopp, Annika, Vehling, Lorena, Becker, Allan B., Mandhane, Piushkumar J., Turvey, Stuart E., Lefebvre, Diana L., Sears, Malcolm R., and Azad, Meghan B.

Published
2017
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16. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma

Author

Subbarao, Padmaja, Anand, Sonia S, Becker, Allan B, Befus, A Dean, Brauer, Michael, Brook, Jeffrey R, Denburg, Judah A, HayGlass, Kent T, Kobor, Michael S, Kollmann, Tobias R, Kozyrskyj, Anita L, Lou, W Y Wendy, Mandhane, Piushkumar J, Miller, Gregory E, Moraes, Theo J, Pare, Peter D, Scott, James A, Takaro, Tim K, Turvey, Stuart E, Duncan, Joanne M, Lefebvre, Diana L, Sears, Malcolm R, OʼByrne, Paul M, Martinez, Fernando D, Raizenne, Mark E, Ratjen, Felix A, Sly, Peter D, von Mutius, Erika, Allen, R, Chen, E, Cyr, M, Daley, D, Dell, S, Elliott, S, Grasemann, H, HayGlass, K, Hegele, R, Holness, DL, Laprise, C, Larché, M, Macri, J, Miller, G, Moqbel, R, Moraes, T, Paré, PD, Ramsey, C, Ratjen, F, Sandford, A, Scott, J, Silverman, F, Takaro, T, Tang, P, Tebbutt, S, To, T, and Turvey, SE

Published
2015
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19. Society Business

Author

Kemp, W. M., Befus, A. Dean, and Mayberry, Lillian F.

Published
1988

35. Intestinal immune responses of mice to the tapeworms Hymenolepis diminuta and H. microstoma

Author

Befus, Albert Dean

Subjects
571.9
Abstract

Previous investigations suggested that adult cestodes do not evoke host immune responses such as those directed against intestinal nematodes, but this is not so and the recent demonstration that Hymenolepis diminuta is expelled from mice by an immunological mechanism provides an excellent model system with which to investigate these responses, H, microstoma provides an interesting comparison with diminuta as, in the mouse, the former survives well despite host immune responses. Following the initial administration of one (Ic) or six (6c) cysticercoids to mice, >80% of H, diminuta can be recovered 8 to 10 days later, but thereafter, worm rejection commences. Prior to rejection, worms grow rapidly. Herein the term 'rejection' includes both destrobilation (loss of the strobila) and expulsion, although only some worms destrobilate prior to being expelled. For objective analyses of the dynamics of infection the following criteria are established: 1) mean survival time - the first day on which >50% of the worms administered had been lost or destrobilated, 2) destrobilated worm - a worm < 0,2 mg dry weight on da 10 or thereafter, and 3) biomass - the total dry weight of all worms recovered on a given day from a group of mice (worms < 0,1 included as 0,1 mg), The mean survival time of 1c primary infections in 6 week old CFLP and NIH male mice can vary from 12 to 18 days but normally was 14-16 days, whereas with 6c infections the raean survival time was invariably 12 days. Worms grow more slowly in 6c than in 1c infections, a well known phenomenon called 'crowding' and previously attributed solely to inter-worm competition for nutrient. However, it may be largely due to potentiated host immune responses in the multiple (6c), more immunogenic, infections. In young, relatively immunologically immature mice (2-4 weeks old at infection), rejection of 1c infections occurs, but is delayed in comparison with infections in older, relatively immunologically mature, mice (5-7 weeks old). Biomass, which combines both worm survival and growth, shows clearly the relative immunological unresponsiveness of young mice to H, diminuta. The unresponsiveness is due to a quantitative rather than an absolute immunological deficiency and the increasing responsiveness of mice to H, diminuta with age correlates well with the maturation of intestinal lymphoid tissue. Mice >7 weeks old may be more responsive than the 2-7 weeks old mice studied herein. Following the natural termination of a primary infection, an enhanced response occurs to secondary infection which is expressed as stunting of the worms. The severity of stunting is directly related to the intensity of the primary and secondary infections, Furthermore, when the primary infection is terminated after 3 days by anthelmintic only limited stunting of secondary worms can be detected, but following a primary infection terminated after 12 days stunting of secondary worms is severe. As protective immunity to H. diminuta is expressed in the lumen of the intestine, a precis of intestinal immune responses is given and double immunodiffusion, single radial immunodiffusion and direct anti-globulin immunofluorescence were used to study the intestinal immune responses of infected mice. No anti H, diminuta antibodies were detected in the sera or intestinal contents of infected or resistant mice and no consistent differences were detected between infected and uninfected mice in the levels of IgA, IgG1, IgG2 and IgM in the sera or intestinal contents. However, all these immunoglobulins occur on the tegument of both H. diminuta and H, microstoma and are probably specific antibodies combining with the antigens which are in the tegument. The third component of complement (C3) was detected fixed to the tegument of H. diminuta but not to H. microstoma although this result is equivocal. The morphology and occurrence of darkened areas in the tegument of H. diminuta are described and it is concluded that they are sites of immunological damage to the worm perhaps induced by the tegument bound antibody and C3. The results are discussed in relation to protective immunity and survival mechanisms of intestinal helminths. The thesis provides essential information for the further characterization of immunity to H. diminuta and strongly urges that knowledge of protective immunity to adult cestodes will be of considerable medical significance.

Published
1975

37. Contributors

Author

Abd-Alla, Mohammed D., primary, Abraham, Soman N., additional, Adams, David, additional, Anderson, Deborah J., additional, Arntzen, Charles J., additional, Atkinson, T. Prescott, additional, Baekkevold, Espen S., additional, Befus, A. Dean, additional, Bergmeier, Lesley Ann, additional, Bergsten, Göran, additional, Berin, M. Cecilia, additional, Bernstein, Joel M., additional, Bevins, Charles L., additional, Bienenstock, John, additional, Bishop, Brian L., additional, Bjersing, Jan, additional, Blumberg, Richard S., additional, Bobek, Libuse A., additional, Boiko, Nadiya, additional, Bos, Nicolaas A., additional, Bost, Kenneth L., additional, Boyaka, Prosper N., additional, Brandtzaeg, Per, additional, Briles, David E., additional, Brock, Jeremy H., additional, Bronson, Richard A., additional, Brown, William R., additional, Buckley, Mark G., additional, Butcher, Eugene C., additional, Butler, John E., additional, Carlsen, Hege S., additional, Cassell, Gail H., additional, Cauci, Sabina, additional, Cebra, John J., additional, Challacombe, Stephen J., additional, Cheroutre, Hilde, additional, Chikwamba, Rachel, additional, Childers, Noel K., additional, Clancy, Robert L., additional, Compans, Richard W., additional, Cone, Richard A., additional, Corbeil, Lynette B., additional, Crane-Godreau, Mardi A., additional, Cripps, Allan W., additional, Cunningham-Rundles, Charlotte, additional, Curtiss, Roy, additional, Czerkinsky, Cecil, additional, Czinn, Steven J., additional, de Jong, Ype, additional, Dent, Gordon, additional, Dertzbaugh, Mark T., additional, DiRita, Victor J., additional, Duchmann, Rainer, additional, Elson, Charles O., additional, Emancipator, Steven N., additional, Estes, Mary K., additional, Fargarasan, Sidonia, additional, Faria, Ana M.C., additional, Farstad, Inger Nina, additional, Fidel, Paul L., additional, Fischer, Hans, additional, Fogg, George, additional, Fujihashi, Kohtaro, additional, Fusi, Francesco M., additional, Fuss, Ivan J., additional, Ganz, Thomas, additional, Garofalo, Roberto P., additional, Genco, Robert J., additional, Gewirtz, Andrew T., additional, Gleeson, Maree, additional, Godaly, Gabriela, additional, Goldblum, Randall M., additional, Grant, Katherine S., additional, Greenberg, Harry B., additional, Haitchi, Hans Michael, additional, Hajishengallis, George, additional, Hamada, Hiromasa, additional, Hanson, Lars Åke, additional, Hardy, R. Doug, additional, Herias, M. Veronica, additional, Herrler, Georg, additional, Herrmann, John E., additional, Hodgins, Douglas C., additional, Hoentjen, Frank, additional, Holgate, Stephen T., additional, Holloway, Judith H., additional, Holmgren, Jan, additional, Hook, Edward W., additional, Hunt, Joan S., additional, Inman, Mark D., additional, Irjala, Heikki, additional, Ishikawa, Hiromichi, additional, Ishikawa, Takeru, additional, Ivanyi, Juraj, additional, Jackson, Susan, additional, Jalkanen, Sirpa, additional, Janoff, Edward N., additional, Jiang, Han-Qing, additional, Kaetzel, Charlotte S., additional, Kanamori, Yutaka, additional, Karp, Loren C., additional, Kato, Tomohiro, additional, Kehrli, Marcus E., additional, Kelsall, Brian L., additional, Kerr, Michael A., additional, Kilian, Mogens, additional, Kiyono, Hiroshi, additional, Knight, Katherine L., additional, Korotkova, Marina, additional, Kraal, George, additional, Kraehenbuhl, Jean-Pierre, additional, Krieg, Arthur M., additional, Krishna, Mamidipudi T., additional, Kroese, Frans G.M., additional, Kronenberg, Mitchell, additional, Kurono, Yuichi, additional, Kutteh, William H., additional, Kweon, Mi-Na, additional, Lamm, Michael E., additional, Lazarus, Nicole, additional, LeFrançois, Leo, additional, Lehner, Thomas, additional, Lehrer, Robert I., additional, Leon, Francisco, additional, Levine, Myron M., additional, Lim, David, additional, Lin, Tong-Jun, additional, Lomonossoff, George P., additional, Lundin, Knut E.A., additional, Lundstedt, Ann-Charlotte, additional, Lycke, Nils, additional, MacDonald, Thomas T., additional, Mahoney, Richard T., additional, Martin, Denis, additional, Mason, Hugh S., additional, Masuyama, Keisuke, additional, Mayer, Lloyd, additional, McDonald, Donald M., additional, McElrath, M. Juliana, additional, McGhee, Jerry R., additional, Mestecky, Jiri, additional, Michalek, Suzanne M., additional, Miller, Christopher J., additional, Miller, Robert D., additional, Mogi, Goro, additional, Molberg, Øyvind, additional, Moldoveanu, Zina, additional, Monteleone, Giovanni, additional, Montgomery, Paul C., additional, Moro, Itaru, additional, Morrison, Richard P., additional, Mostov, Keith, additional, Mowat, Allan Mcl., additional, Murphy, Brian R., additional, Nataro, James P., additional, Nedrud, John G., additional, Neutra, Marian R., additional, Nowicki, Stella, additional, O'Byrne, Paul M., additional, Ofek, Itzhak, additional, Ogra, Pearay L., additional, O'Hagan, Derek T., additional, Okamoto, Yoshitaka, additional, Orihuela, Carlos J., additional, Osterhaus, Albert D.M.E., additional, O'Sullivan, Nancy L., additional, Owen, Robert L., additional, Page, Roy C., additional, Parr, Margaret B., additional, Parr, Earl L., additional, Parreño, Viviana, additional, Pascual, David W., additional, Peppard, Jane V., additional, Petroff, Margaret G., additional, Pudney, Jeffrey, additional, Ravdin, Jonathan I., additional, Renegar, Kathryn B., additional, Rhee, Ki-Jong, additional, Rimmelzwaan, Guus F., additional, Robertson, Anna-Karin, additional, Robinson, Harriett L., additional, Rosenthal, Kenneth L., additional, Rothenberg, Marc E., additional, Rouse, Barry T., additional, Rubins, Jeffrey B., additional, Russell, Michael W., additional, Saif, Linda J., additional, Salmi, Marko, additional, Sampson, Hugh A., additional, Samuelsson, Patrick, additional, Santi, Luca, additional, Sartor, R. Balfour, additional, Savage, Dwayne C., additional, Schmid, D. Scott, additional, Sharon, Nathan, additional, Shirlaw, Penelope J., additional, Smith, Phillip D., additional, Smythies, Leslie E., additional, Sollid, Ludvig, additional, Sparling, P. Frederick, additional, Spearman, Paul W., additional, Spencer, Jo, additional, Strober, Warren, additional, Su, Wen, additional, Sullivan, David A., additional, Svanborg, Catharina, additional, Svennerholm, Ann-Mari, additional, Svensson, Maj-Lis, additional, Targan, Stephan R., additional, Taubman, Martin A., additional, Telemo, Esbjörn, additional, Tenovuo, Jorma, additional, Terhorst, Cox, additional, Tlaskalova-Hogenova, Helena, additional, Tristram, Debra A., additional, Tuomanen, Elaine, additional, Underdown, Brian J., additional, van Egmond, Marjolein, additional, Vijay-Kumar, Matam, additional, Wahl, Sharon W., additional, Walker, W. Allan, additional, Ward, Richard L., additional, Weaver, Casey T., additional, Weiner, Howard L., additional, Welliver, Robert C., additional, Wira, Charles R., additional, Woof, Jenny M., additional, Wotherspoon, Andrew C., additional, Youngman, Kenneth R., additional, Yuan, Lijuan, additional, and Zeitz, Martin, additional

Published
2005
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39. A novel submandibular gland peptide protects against endotoxic and anaphylactic shock

Author

Mathison, Ronald D., Befus, A. Dean, and Davison, Joseph S.

Subjects
Peptides -- Research, Salivary glands -- Research, Septic shock -- Research, Anaphylaxis -- Research, Biological sciences
Abstract

A novel heptapeptide with the sequence TDIFEGG, called submandibular gland peptide T (SGP-T), was isolated from extracts of submandibular glands of rats and then synthesized. Results showed that lower doses of SGP-T effectively prevented endotoxin-induced hypotension in sialadenectomized rats. The peptide also exhibited the ability to inhibit antigen-induced hypotension in a model of anaphylaxis model. Distinct mechanisms in attenuating endotoxic and anaphylactic shock are indicated.

Published
1997

45. Temporal analysis of the anti-inflammatory effects of decentralization of the rat superior cervical ganglia

Author

Mathison, Ronald, Carter, Lisa, Mowat, Connie, Bissonnette, Elyse, Davison, Joseph S., and Befus, A. Dean

Subjects
Ganglia, Autonomic -- Physiological aspects, Lungs -- Inflammation, Neutrophils -- Physiological aspects, Biological sciences
Abstract

Downregulation of macrophage and neutrophil functions weakens anaphylaxis-stimulated pulmonary inflammation during superior cervical ganglia (SCG) decentralization. SCG bilateral decentralization lowers pulmonary inflammation which precedes anaphylaxis induction. The pulmonary inflammatory reaction which involves fluid accumulation in the perivascular spaces is associated with a large number of neutrophils and macrophages in the bronchoalveolar lavage fluid.

Published
1994

50. Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein

Author

Befus A Dean, Davison Joseph S, Mathison Ronald D, and Gingerich Daniel A

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Abstract The limitations of steroidal and non steroidal anti-inflammatory drugs have prompted investigation into other biologically based therapeutics, and identification of immune selective anti-inflammatory agents of salivary origin. The traditional view of salivary glands as accessory digestive structures is changing as their importance as sources of systemically active immunoregulatory and anti-inflammatory factors is recognized. Salivary gland involvement in maintenance of whole body homeostasis is regulated by the nervous system and thus constitutes a "neuroendocrine axis". The potent anti-inflammatory activities, both in vivo and in vitro, of the tripeptide Phe-Glu-Gly (FEG) are reviewed. FEG is a carboxyl terminal peptide of the prohormone SMR1 identified in the rat submandibular salivary gland, The D-isomeric form (feG) mimics the activity of its L-isomer FEG. Macropharmacologically, feG attenuates the cardiovascular and inflammatory effects of endotoxemia and anaphylaxis, by inhibition of hypotension, leukocyte migration, vascular leak, and disruption of pulmonary function and intestinal motility. Mechanistically, feG affects activated inflammatory cells, especially neutrophils, by regulating integrins and inhibiting intracellular production of reactive oxygen species. Pharmacodynamically, feG is active at low doses (100 μg/kg) and has a long (9-12 hour) biological half life. As a therapeutic agent, feG shows promise in diseases characterized by over exuberant inflammatory responses such as systemic inflammatory response syndrome and other acute inflammatory diseases. Arthritis, sepsis, acute pancreatitis, asthma, acute respiratory inflammation, inflammatory bowel disease, and equine laminitis are potential targets for this promising therapeutic peptide. The term "Immune Selective Anti-Inflammatory Derivatives" (ImSAIDs) is proposed for salivary-derived peptides to distinguish this class of agents from corticosteroids and nonsteroidal anti-inflammatory drugs.

Published
2010
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