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3. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

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Kakkar, Ajay K., Bassand, Jean-Pierre, John Camm, A., Fitzmaurice, David A., Goldhaber, Samuel Z., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, Verheugt, Freek W.A., Kayani, Gloria, Fox, Keith A.A., Gersh, Bernard J., Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J., Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Jansky, Petr, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, Kakkar, Sanjay, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Atar, Dan, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Fitzmaurice, David, Hu, D.Y., Chen, K.N., Zhao, Y.S., Zhang, H.Q., Chen, J.Z., Cao, S.P., Wang, D.W., Yang, Y.J., Li, W.H., Yin, Y.H., Tao, G.Z., Yang, P., Chen, Y.M., He, S.H., Wang, Ying, Wang, Yong, Fu, G.S., Li, X., Wu, T.G., Cheng, X.S., Yan, X.W., Zhao, R.P., Chen, M.S., Xiong, L.G., Chen, P., Jiao, Y., Guo, Y., Xue, L., Wang, F.Z., Li, H., Yang, Z.M., Bai, C.L., Chen, J., Chen, J.Y., Chen, X., Feng, S., Fu, Q.H., Gao, X.J., Guo, W.N., He, R.H., He, X.A., Hu, X.S., Huang, X.F., Li, B., Li, J., Li, L., Li, Y.H., Liu, T.T., Liu, W.L., Liu, Y.Y., Lu, Z.C., Luo, X.L., Ma, T.Y., Peng, J.Q., Sheng, X., Shi, X.J., Sun, Y.H., Tian, G., Wang, K., Wang, L., Wu, R.N., Xie, Q., Xu, R.Y., Yang, J.S., Yang, L.L., Yang, Q., Ye, Y., Yu, H.Y., Yu, J.H., Yu, T., Zhai, H., Zhan, Q., Zhang, G.S., Zhang, Q., Zhang, R., Zhang, Y., Zheng, W.Y., Zhou, B., Zhou, Z.H., Zhu, X.Y., Kakkar, S., Sawhney, J.P.S., Jadhav, P., Durgaprasad, R., Ravi Shankar, A.G., Rajput, R.K., Bhargava, K., Sarma, R., Srinivas, A., Roy, D., Nagamalesh, U.M., Chopda, M., Kishore, R., Kulkarni, G., Chandwani, P., Pothiwala, R.A., Padinhare Purayil, M., Shah, S., Chawla, K., Kothiwale, V.A., Raghuraman, B., Vijayaraghavan, G., Vijan, V.M., Bantwal, G., Bisne, V., Khan, A., Gupta, J.B., Kumar, S., Jain, D., Abraham, S., Adak, D., Barai, A., Begum, H., Bhattacharjee, P., Dargude, M., Davies, D., Deshpande, B., Dhakrao, P., Dhyani, V., Duhan, S., Earath, M., Ganatra, A., Giradkar, S., Jain, V., Karthikeyan, R., Kasala, L., Kaur, S., Krishnappa, S., Lawande, A., Lokesh, B., Madarkar, N., Meena, R., More, P., Naik, D., Prashanth, K., Rao, M., Rao, N.M., Sadhu, N., Shah, D., Sharma, M., Shiva, P., Singhal, S., Suresh, S., Vanajakshamma, V., Panse, S.G., Koretsune, Y., Kanamori, S., Yamamoto, K., Kumagai, K., Katsuda, Y., Sadamatsu, K., Toyota, F., Mizuno, Y., Misumi, I., Noguchi, H., Ando, S., Suetsugu, T., Minamoto, M., Oda, Hiroshi, Shiraishi, K., Adachi, S., Chiba, K., Norita, H., Tsuruta, M., Koyanagi, T., Ando, H., Higashi, T., Okada, K., Azakami, S., Komaki, S., Kumeda, K., Murayama, T., Matsumura, J., Oba, Y., Sonoda, R., Goto, K., Minoda, K., Haraguchi, Y., Suefuji, H., Miyagi, H., Kato, H., Nakamura, Tadashi, Nakamura, Tsugihiro, Nandate, H., Zaitsu, R., Fujiura, Yoshihisa, Yoshimura, A., Numata, H., Ogawa, J., Tatematsu, H., Kamogawa, Y., Murakami, K., Wakasa, Y., Yamasawa, M., Maekawa, H., Abe, S., Kihara, H., Tsunoda, S., Saito, Katsumi, Saito, Kazuyuki, Fudo, T., Obunai, K., Tachibana, H., Oba, I., Kuwahata, T., Higa, S., Gushiken, M., Eto, T., Yoshida, H., Ikeda, D., Fujiura, Yoshitake, Ishizawa, M., Nakatsuka, M., Murata, K., Ogurusu, C., Shimoyama, M., Akutsu, M., Takamura, I., Hoshino, F., Yokota, N., Iwao, T., Tsuchida, K., Takeuchi, M., Hatori, Y., Kitami, Y., Nakamura, Yoichi, Oyama, R., Ageta, M., Oda, Hiroyuki, Go, Y., Mishima, K., Unoki, T., Morii, S., Shiga, Yuhei, Sumi, H., Nagatomo, T., Sanno, K., Fujisawa, K., Atsuchi, Y., Nagoshi, T., Seto, T., Tabuchi, T., Kameko, M., Nii, K., Oshiro, K., Takezawa, H., Nagano, S., Miyamoto, N., Iwaki, M., Nakamura, Yuichiro, Fujii, M., Okawa, M., Abe, Masahiko, Abe, Masatake, Abe, Mitsunori, Saito, T., Mito, T., Nagao, K., Minami, J., Mita, T., Sakuma, I., Taguchi, T., Marusaki, S., Doi, H., Tanaka, M., Fujito, T., Matsuta, M., Kusumoto, T., Kakinoki, S., Ashida, K., Yoshizawa, N., Agata, J., Arasaki, O., Manita, M., Ikemura, M., Fukuoka, S., Murakami, H., Matsukawa, S., Hata, Y., Taniguchi, T., Ko, T., Kubo, H., Imamaki, M., Akiyama, M., Inagaki, M., Odakura, H., Ueda, T., Katsube, Y., Nakata, A., Watanabe, H., Techigawara, M., Igarashi, M., Taga, K., Kimura, T., Tomimoto, S., Shibuya, M., Nakano, M., Ito, K., Seo, T., Hiramitsu, S., Hosokawa, H., Hoshiai, M., Hibino, M., Miyagawa, K., Horie, Hajime, Sugishita, N., Shiga, Yukio, Soma, A., Neya, K., Yoshida, Tetsuro, Yoshida, Tomoki, Mizuguchi, M., Ishiguro, M., Minagawa, T., Wada, M., Mukawa, H., Okuda, F., Nagasaka, S., Abe, Y., Adachi, Sen, Adachi, Susumu, Adachi, T., Akahane, K., Amano, T., Aoki, K., Aoyama, T., Arai, H., Arima, S., Arino, T., Asano, H., Asano, T., Azuma, J., Baba, T., Betsuyaku, T., Chibana, H., Date, H., Doiuchi, J., Emura, Y., Endo, M., Fujii, Y., Fujiki, R., Fujisawa, A., Fujisawa, Y., Fukuda, T., Fukui, T., Furukawa, N., Furukawa, T., Furumoto, W., Goto, T., Hamaoka, M., Hanazono, N., Hasegawa, K., Hatsuno, T., Hayashi, Y., Higuchi, K., Hirasawa, K., Hirayama, H., Hirose, M., Hirota, S., Honda, M., Horie, Hideki, Ido, T., Iiji, O., Ikeda, H., Ikeda, K., Ikeoka, K., Imaizumi, M., Inaba, H., Inoue, T., Iseki, F., Ishihara, A., Ishioka, N., Ito, N., Iwase, T., Kakuda, H., Kamata, J., Kanai, H., Kanda, H., Kaneko, M., Kano, H., Kasai, T., Kato, T., Kato, Y., Kawada, Y., Kawai, K., Kawakami, K., Kawakami, S., Kawamoto, T., Kawano, S., Kim, J., Kira, T., Kitazawa, H., Kitazumi, H., Kito, T., Kobayashi, T., Koeda, T., Kojima, J., Komatsu, H., Komatsu, I., Koshibu, Y., Kotani, T., Kozuka, T., Kumai, Y., Kumazaki, T., Maeda, I., Maeda, K., Maruyama, Y., Matsui, S., Matsushita, K., Matsuura, Y., Mineoi, K., Mitsuhashi, H., Miura, N., Miyaguchi, S., Miyajima, S., Miyamoto, H., Miyashita, A., Miyata, S., Mizuguchi, I., Mizuno, A., Mori, T., Moriai, O., Morishita, K., Murai, O., Nagai, Sho, Nagai, Shunichi, Nagata, E., Nagata, H., Nakagomi, A., Nakahara, S., Nakamura, M., Nakamura, R., Nakanishi, N., Nakayama, T., Nakazato, R., Nanke, T., Nariyama, J., Niijima, Y., Niinuma, H., Nishida, Y., Nishihata, Y., Nishino, K., Nishioka, H., Nishizawa, K., Niwa, I., Nomura, K., Nomura, S., Nozoe, M., Ogawa, T., Ohara, N., Okada, M., Okamoto, K., Okita, H., Okuyama, M., Ono, H., Ono, T., Onuki Pearce, Y., Oriso, S., Ota, A., Otaki, E., Saito, Y., Sakai, H., Sakamoto, N., Sakamoto, Y., Samejima, Y., Sasagawa, Y., Sasaguri, H., Sasaki, A., Sasaki, T., Sato, Kazuki, Sato, Kiyoharu, Sawano, M., Seki, S., Sekine, Y., Seta, Y., Sezaki, K., Shibata, N., Shiina, Y., Shimono, H., Shimoyama, Y., Shindo, T., Shinohara, H., Shinohe, R., Shinozuka, T., Shirai, T., Shiraiwa, T., Shozawa, Y., Suga, T., Sugimoto, C., Suzuki, Kazuo, Suzuki, Keita, Suzuki, Shu, Suzuki, Shunji, Suzuki, Susumu, Suzuki, Y., Tada, M., Taguchi, A., Takagi, T., Takagi, Y., Takahashi, K., Takahashi, S., Takai, H., Takanaka, C., Take, S., Takeda, H., Takei, K., Takenaka, K., Tana, T., Tanabe, G., Taya, K., Teragawa, H., Tohyo, S., Toru, S., Tsuchiya, Y., Tsuji, T., Tsuzaki, K., Uchiyama, H., Ueda, O., Ueyama, Y., Wakaki, N., Wakiyama, T., Washizuka, T., Watanabe, M., Yamada, T., Yamagishi, T., Yamaguchi, H., Yamamoto, Kenichi, Yamamoto, Kentaro, Yamamoto, Kunihiko, Yamamoto, T., Yamaura, M., Yamazoe, M., Yasui, K., Yokoyama, Y., Yoshida, K., Lim, T.W., Ching, C.K., Foo, C.G., Chow, J.H., Chen, D.D., Jaufeerally, F.R., Lee, Y.M., Lim, G., Lim, W.T., Thng, S., Yap, S.Y., Yeo, C., Oh, S., Pak, H.N., Kim, J.-B., Kim, J.H., Jang, S.-W., Kim, D.H., Ryu, D.R., Park, S.W., Kim, D.-K., Choi, D.J., Oh, Y.S., Cho, M.-C., Kim, S.-H., Jeon, H.-K., Shin, D.-G., Park, J.S., Park, H.K., Han, S.-J., Sung, J.H., Cho, J.-G., Nam, G.-B., On, Y.K., Lim, H.E., Kwak, J.J., Cha, T.-J., Hong, T.J., Park, S.H., Yoon, J.H., Kim, N.-H., Kim, K.-S., Jung, B.C., Hwang, G.-S., Kim, C.-J., Kim, D.B., Ahn, J.J., An, H.J., Bae, H., Baek, A.L., Chi, W.J., Choi, E.A., Choi, E.H., Choi, H.K., Choi, H.S., Han, S., Heo, E.S., Her, K.O., Hwang, S.W., Jang, E.M., Jang, H.-S., Jang, S., Jeon, H.-G., Jeon, S.R., Jeon, Y.R., Jeong, H.K., Jung, I.-A., Kim, Hyeon Jeong, Kim, Hyun Ju, Kim, Ji Seon, Kim, Jung Sook, Kim, J.A., Kim, K.T., Kim, M.S., Kim, Sang Hee, Kim, Sang Hyun, Kim, Y.-I., Lee, C.S., Lee, E.H., Lee, G.H., Lee, H.Y., Lee, H.-Y., Lee, K.H., Lee, K.R., Lee, M.S., Lee, M.-Y., Lee, R.W., Lee, S.E., Lee, S.H., Lee, S., Lee, W.Y., Noh, I.K., Park, A.R., Park, B.R., Park, H.N., Park, J.H., Park, M., Park, Y., Seo, S.-Y., Shim, J., Sim, J.H., Sohn, Y.M., Son, W.S., Son, Y.S., Song, H.J., Wi, H.K., Woo, J.J., Ye, S., Yim, K.H., Yoo, K.M., Yoon, E.J., Yun, S.Y., Angchaisuksiri, P., Chawanadelert, S., Mongkolwongroj, P., Kanokphatcharakun, K., Cheewatanakornkul, S., Laksomya, T., Pattanaprichakul, S., Chantrarat, T., Rungaramsin, S., Silaruks, S., Wongcharoen, W., Siriwattana, K., Likittanasombat, K., Katekangplu, P., Boonyapisit, W., Cholsaringkarl, D., Chatlaong, B., Chattranukulchai, P., Santanakorn, Y., Hutayanon, P., Khunrong, P., Bunyapipat, T., Jai-Aue, S., Kaewsuwanna, P., Bamungpong, P., Gunaparn, S., Hongsuppinyo, S., Inphontan, R., Khattaroek, R., Khunkong, K., Kitmapawanont, U., Kongsin, C., Naratreekoon, B., Ninwaranon, S., Phangyota, J., Phrommintikul, A., Phunpinyosak, P., Pongmorakot, K., Poomiphol, S., Pornnimitthum, N., Pumprueg, S., Ratchasikaew, S., Sanit, K., Sawanyawisuth, K., Silaruks, B., Sirichai, R., Sriwichian, A., Suebjaksing, W., Sukklad, P., Suttana, T., Tangsirira, A., Thangpet, O., Tiyanon, W., Vorasettakarnkij, Y., Wisaratapong, T., Wongtheptien, W., Wutthimanop, A., Yawila, S., Oto, A., Altun, A., Ozdogru, I., Ozdemir, K., Yilmaz, O., Aydinlar, A., Yilmaz, M.B., Yeter, E., Ongen, Z., Cayli, M., Pekdemir, H., Ozdemir, M., Sucu, M., Sayin, T., Demir, M., Yorgun, H., Ersanli, M., Okuyan, E., Aras, D., Abdelrahman, H., Aktas, O., Alpay, D., Aras, F., Bireciklioglu, M.F., Budeyri, S., Buyukpapuc, M., Caliskan, S., Esen, M., Felekoglu, M.A., Genc, D., Ikitimur, B., Karaayvaz, E.B., Kılıç Karataş, S., Okutucu, S., Ozcelik, E., Quisi, A., Sag, H., Sahiner, L., Sayin, B.Y., Seker, T., Uzun Alkan, D., Yildirim, E., Yildirim, R., Yilmaz, F., Yuksekdag, V., Luciardi, H.L., Vensentini, N., Ingaramo, A.C., Sambadaro, G.A., Fernandez Caputi, V., Berman, S.G., Dragotto, P., Kleiban, A.J., Centurion, N., Giacomi, G., Ahuad Guerrero, R.A., Conde, D., Zapata, G., Di Paola, L.A., Ramos, J.L., Dran, R.D., Egido, J., Fernandez, A.A., Fosco, M.J., Sassone, S., Sinisi, V.A., Cartasegna, L.R., Berli, M.A., Gomez Vilamajo, O.A., Ferroni, F., Alaguibe, E.D., Alvarez D'Amelio, A., Arabetti, C., Arias, L., Belardi, J.A., Bergesio, L., Berli, F., Berli, M., Borchowiec, S., Buzzetti, C., Cabrini, R., Campisi, V., Cappi, A.L., Carrizo, R., Colombo Berra, F., Costabel, J.P., Costamagna, O.J.A., Damonte, A.A., De Urquiza, I.N., Diez, F., Edén, M.F., Fanuele, M., Fernandez Voena, F., Foa Torres, M., Funosas, C., Giacomi, M.P., Gimenez, C.H., Gurfinkel, E.P., de L.M. Had, M., Hansen, V., Hrabar, A.D., Ingratta, M., Lopez, A., Maehara, G., Maffei, L., Martinelli, A., Martinelli, C., Matkovich, J., Mautner, B., Meirino, A., Munguia, R., Navarro, A., Novas, V., Perez Prados, G., Pontoriero, J., Potito, R.N., Ricotti, C., Rodriguez, M.A., Rolandi, F., Said Palladino, M.E., Salinger, M., Sanziani, L.S., Schygiel, P.O., Sossich, A., Tinto, J.F., Tonelli, L., Tufare, A.L., Vallejo, M., Yunis, M.E., Zillo, M., Zurbrigk, F.J., Barretto, A.C.P., Sobral Filho, D.C., Jaber, J., Armaganijan, D., Faria Neto, J., Steffens, A., Kunz Sebba Barroso de Souza, W., de Souza Neto, J.D., Ribeiro, J.M., Silveira Teixeira, M., Ferreira Rossi, P.R., Pires, L., Moreira, D., Moura Jorge, J.C., Menezes Lorga Filho, A., Bodanese, L.C., Westerlund Montera, M., Del Carlo, C.H., Da Rocha Rodrigues, T., Alves da Costa, F.A., Lopes, A., Lopes, R., Araújo, G.R., Fernandes Manenti, E.R., Kerr Saraiva, J.F., Ferreira Braga, J.C., Negri, A., Souto, L., Moncada, C., Bertolim Precoma, D., Roquette, F., Reis, G., Ramos Filho, R.A., Lanna Figueiredo, E., Vieira Botelho, R., Munhoz da Fontoura Tavares, C., Costantini Frack, C.R., Abdalla Saad, J., Finimundi, H.C., Pisani, C., Chemello, D., Pereira Martins, M., Broilo França, C.C., Alban, F., Aranha Rosito, G.B., de Moura Xavier Moraes Junior, J.B., Tumelero, R.T., Nigro Maia, L., Simões de Almeida, R., do Carmo Borges, N.C., Gomes Ferreira, L.G., Agliardi, P., Alves de Oliveira Gomes, J., Araujo, V., Arruda Nakazone, M., Barbosa, T., Barroso, S., Belisario Falchetto, E., Bellotti Lopes, H., Benez Teixeira Lemos, M.A., Biazus, G., Borges Queiroz, L., Camazzola, F.E., Caporale, M., Cardoso Boscato, S., Chieza, F., Chokr, M.O., Clemente Mingireanov, R., Codonho Góes, N., Correa, C., Costa, M., Costantini Ortiz, C., da Silva, L.S., da Silva Paulitsch, F., da Silveira, J.A., Daros, E., de Araújo, G.R., Del Monaco, M.I., Dias, C., Dias, M.A., Drummond Wainstein, A.P., Ely Pizzato, P., Esteves, D.C., Fabri, P., Félix Lorenzato Fonseca, T., Fernandes, E., Fonseca, C., Frack Costantini, C.R., Franchin Ferraz, R., Freire, F., Gottardo, P., Guanaes, D., Guizzardi, S., Hettwer Magedanz, E., Igansi, F., Jannuzzi, F., Junior, G., Komar, D., Lino, E.G., Lopes, D., Lourenço da Silva Júnior, O., Lustosa, E., Macagnan, A.P., Marinho, M.C., Mazzoni, M., Melo, G., Mortari, L., Mouco, O.M.C.C., Nanzer Vital, C., Ormundo, C., Oss Emmer, S., Palmegiani, E., Pavani, R., Pereira, L., Pereira, V.L., Perreira, R., Poletti, S., Quaia Fortunato, S.C., Queirantes, C., Ramos Pereira, N., Rech, R.L., Ribeiro, S., Rodrigues, A., Roesch, H., Ruaro Reichert, T., Santos, D., Santos, I., Santos, M., Seroqui, M.V., Silva, S., Soares, L., Spolaor, L., Stoll, C., Toazza Duda, N., Trama, L., Unterkircher, B., Valois, M.V., Vargas, T., Viana, T., Vicente, C., Vidal Armaganijan, L., Vieira Homem, R., Vieira Torres, L.G., Vila Boas, L., Villaça Guimarães Filho, F., Corbalan, R., Eggers, G., Bugueño Gutiérrez, C., Arriagada, G., Potthoff Cardenas, S., Stockins Fernandez, B.A.J., Conejeros, C., Houzvic, C., Marin Cuevas, P., Montecinos, H., Forero, A., Lanas, F., Larico Gómez, M., Charme Vilches, G., Rey, C., Astudillo, C., Aguilar, J., Campisto, Y., Lara, C., Molina, E., Munoz Oyarzon, J., Olguin, V., Vergara, M., Villan, C., Sánchez Díaz, C.J., Illescas Diaz, J., Leal Cantú, R., Ramos Zavala, M.G., Cabrera Jardines, R., Espinola Zavaleta, N., Villarreal Umaña, S., López Rosas, E., Llamas Esperón, G., Pozas, G., Cardona Muñoz, E., Matadamas Hernández, N., Leyva Rendón, A., García Hernández, N., de los Ríos Ibarra, M., Virgen Carrillo, L., López Villezca, D., Hernández Herrera, C., López Prieto, J.J., Gaona Rodríguez, R., Villeda Espinosa, E., Flores Martínez, D., Velasco Barcena, J., Yong, R., Rodríguez Briones, I., Leiva Pons, J.L., Álvarez López, H., Olvera Ruiz, R., Díaz de la Vega, C., Cantú Brito, C., Chuquiure Valenzuela, E., Reyes-Sanchez, R., Bazzoni Ruiz, A., Nandayapa Flores, O., Benavides Gonzalez, M., Arriaga Nava, R., Morales Cerda, J.D., Fierro Fierro, O., Fajardo Campos, P., Alfaro, T.A.A., Altamirano Bellorin, S., Avena, R., Chavarria, M., Espinosa, I., Flores Silva, F., Garcia Nava, R.H., Godoy, K., Gonzalez Felix, E.J., Gonzalez Garcia, C.L., Gonzalez Salas, L.G., Guajardo, P., Hernandez Gonzalez, S., Izquierdo, T., Mancilla Ortiz, M.C., Martinez Vasquez, D., Mendoza, N., Morales, J., Nikitina, N., Ochoa Aybar, S., Ortiz, A., Padilla Macias, P., Perez, F., Perez Sanchez, J.A., Piña Toledano, S., Ramos Gonzalez, M., Rivera Ramos, C., Roa Castro, V., Romero Cardona, G., Ruiz Cornejo, M., Salinas, A., Santana, G., Sida Perez, P., Tovar Castaneda, A.C., Trujillo Cortes, R., Brodmann, M., Lenz, K., Drexel, H., Foechterle, J., Hagn, C., Podczeck-Schweighofer, A., Huber, K., Winkler, M., Schneeweiß, B., Gegenhuber, A., Lang, W., Eichinger-Hasenauer, S., Kaserer, P., Sykora, J., Rasch, H., Pichler, M., Schaflinger, E., Strohmer, B., Breier, R., Ebner, K.-M., Eischer, L., Freihoff, F., Lischka-Lindner, A., Mark, T., Mirtl, A., Said, A., Stöcklöcker, C., Vogel, B., Vonbank, A., Wöhrer, C., Zanolin, D., Cools, F., Paparella, G., Vandergoten, P., Parqué, J.-L., Capiau, L., Vervoort, G., Wollaert, B., Desfontaines, P., Mairesse, G., Boussy, T., Godart, P., De Wolf, A., Voet, J., Heyse, A., Hollanders, G., Anné, W., Vercammen, J., Purnode, P., Blankoff, I., Faes, D., Balthazar, Y., Beutels, M., Maréchal, P., Verstraete, S., Xhaet, O., Striekwold, H., Thoeng, J., Hermans, K., Alzand, B., Ascoop, A.-K., Banaeian, F., Barbuto, A.-M., Billiaux, A.C., Blockmans, M., Bouvy, C., Brike, C., Capiau, H., Casier, T., Conde Y Bolado, A., De Cleen, D., De Coninck, M., de Vos, M., de Weerdt, N., Delforge, M., Delvigne, M., Denie, D., Derycker, K., Deweerd, E., Dormal, F., Drieghe, S., Everaert, M., Eykerman, T., Feys, E., Ghekiere, M., Gits, F., Hellemans, S., Helvasto, L., Jacobs, C., Lips, S., Mestdagh, I., Nimmegeers, J., Piamonte, V., Pollet, P., Postolache, A., Raepers, M., 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C., Ohlin, A.-M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Steffel, J., Beer, J.H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Parkhomenko, A., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P.S., Ross, A., Kainth, M.S., Pickavance, G., McDonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J.A., Ainsworth, P., Jones, C.P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R.P., Wong, S.W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D.F., Bradshaw, C., Van Zon, G., Jones, K.P., Thomas, M.J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A.R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J.L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N.I., Thompson, R., Chigbo, C., Zaidi, S.M.A., Howard, M., Butter, K.C., Barrow, S., Little, H., Haq, I.U., Gibbons, L., Glencross, S., McLeod, A.J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R.N., Lowe, S., Kamath, R., Dau, H.S., Webster, J., Hodgins, I., Vercoe, S., Roome, P.C., Pinnock, H., Patel, J.R.A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C.A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A.C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R.T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., McGinty, P., Wastling, R., McEleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P.B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M.H., Hayes, K., Hegde, M.P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., MacKenzie, M., McCarthy, C., McIntosh, C., McKeon, L., Morrison, H., Mussap, C., Myers, J.-D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I.M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S.J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A.S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., MacDonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M.-C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A.M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S.K., El Din, M.G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E.M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S.Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W.M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., DePauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J.A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., Worthy, V., Sawhney, Jitendra PS., Kothiwale, Veerappa A., Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, and Allu, Jagan

Published
2018
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8. Dépistage génétique en cascade de l’hypercholestérolémie familiale - Une nouvelle opportunité pour la prévention cardiovasculaire [Cascade genetic testing of familial hypercholesterolemia A new opportunity for prevention]

Author

Butty, A., Von Känel, T., Gallino, A., Beer, J.H., and Nanchen, D.

Subjects
Early Diagnosis, Genetic Testing, Humans, Hyperlipoproteinemia Type II/diagnosis, Hyperlipoproteinemia Type II/genetics, Life Style, Switzerland/epidemiology
Abstract

Familial hypercholesterolemia (FH) is a genetic disorder associated with an increased risk of early-onset cardiovascular events. Because lifestyle interventions and lipid-lowering drugs can strongly reduce cardiovascular risk, the early diagnosis of FH is important. Indeed, given the autosomal dominant transmission of the pathogenic variant, a genetic cascade screening program of first-degree relatives from an index case could identify patients at high cardiovascular risk. In Switzerland, genetic testing for FH is rarely used, because it is not reimbursed by health insurance companies. To test the usefulness of cascade genetic testing for FH, the CATCH study is currently ongoing in all linguistic part of Switzerland.

Published
2022

9. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Author

Weiner, J., Suwalski, P., Holtgrewe, M., Rakitko, A., Thibeault, C., Müller, M., Patriki, D., Quedenau, C., Krüger, U., Ilinsky, V., Popov, I., Balnis, J., Jaitovich, A., Helbig, E.T., Lippert, L.J., Stubbemann, P., Real, L.M., Macías, J., Pineda, J.A., Fernandez-Fuertes, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Salvo, M., Blueher, A., Siemann, S., Jurisic, S., Beer, J.H., Rutishauser, J., Wiggli, B., Schmid, H., Danninger, K., Binder, R., Corman, V.M., Mühlemann, B., Arjun Arkal, R., Fragiadakis, G.K., Mick, E., Calfee, C.S., Erle, D.J., Hendrickson, C.M., Kangelaris, K.N., Krummel, M.F., Woodruff, P.G., Langelier, C.R., Venkataramani, U., García, F., Zyla, J., Drosten, C., Braun, A., Jones, T.C., Suttorp, N., Witzenrath, M., Hippenstiel, S., Zemojtel, T., Skurk, C., Wolfgang, P., Borodina, T., Ripke, S., Sander, L.E., Beule, D., Landmesser, U., Guettouche, T., Kurth, F., and Heidecker, B.

Subjects
Technology Platforms
Abstract

BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors that affect individual immune response to SARS-CoV-2. We sought to evaluate this hypothesis by conducting a multicenter study using HLA sequencing. METHODS: We analyzed the association between COVID-19 severity and HLAs in 435 individuals from Germany ((n) = 135), Spain ((n) = 133), Switzerland ((n) = 20) and the United States ((n) = 147), who had been enrolled from March 2020 to August 2020. This study included patients older than 18 years, diagnosed with COVID-19 and representing the full spectrum of the disease. Finally, we tested our results by meta-analysing data from prior genome-wide association studies (GWAS). FINDINGS: We describe a potential association of HLA-C*04:01 with severe clinical course of COVID-19. Carriers of HLA-C*04:01 had twice the risk of intubation when infected with SARS-CoV-2 (risk ratio 1.5 [95% CI 1.1-2.1], odds ratio 3.5 [95% CI 1.9-6.6], adjusted (p)-value = 0.0074). These findings are based on data from four countries and corroborated by independent results from GWAS. Our findings are biologically plausible, as HLA-C*04:01 has fewer predicted bindings sites for relevant SARS-CoV-2 peptides compared to other HLA alleles. INTERPRETATION: HLA-C*04:01 carrier state is associated with severe clinical course in SARS-CoV-2. Our findings suggest that HLA class I alleles have a relevant role in immune defense against SARS-CoV-2.

Published
2021

10. Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

Author

Spescha, R.D., Klohs, J., Semerano, A., Giacalone, G., Derungs, R.S., Reiner, M.F., Rodriguez Gutierrez, D., Mendez-Carmona, N., Glanzmann, M., Savarese, G., Kränkel, N., Akhmedov, A., Keller, S., Mocharla, P., Kaufmann, M.R., Wenger, R.H., Vogel, J., Kulic, L., Nitsch, R.M., Beer, J.H., Peruzzotti-Jametti, L., Sessa, M., Lüscher, T.F., and Camici, G.G.

Published
2015
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13. Therapeutic MMP-2 knockdown blunts age-dependent carotid stiffness by decreasing elastin degradation and augmenting enos activation

Author

Puspitasari, Y.M., primary, Diaz-Canestro, C., additional, Liberale, L., additional, Guzik, T.J., additional, Flammer, A.J., additional, Bonetti, N.R., additional, Wüst, P., additional, Constantino, S., additional, Paneni, F., additional, Akhmedov, A., additional, Beer, J.H., additional, Ruschitzka, F., additional, Hermann, M., additional, Lüscher, T.F., additional, Sudano, I., additional, and Camici, G.G., additional

Published
2021
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15. The role of matrix metalloproteinase-2 on age-dependent arterial stiffness

Author

Puspitasari, Y.M, primary, Diaz-Canestro, C, additional, Sudano, I, additional, Flammer, A, additional, Bonetti, N.R, additional, Wuest, P, additional, Liberale, L, additional, Constantino, S, additional, Paneni, F, additional, Ruschitzka, F, additional, Beer, J.H, additional, Hermann, M, additional, Luscher, T.F, additional, and Camici, G.G, additional

Published
2020
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16. Association of biomarkers of inflammation with hospitalization for heart failure and death in patients with atrial fibrillation

Author

Benz, A.P, primary, Aeschbacher, S, additional, Krisai, P, additional, Blum, S, additional, Meyre, P, additional, Blum, M.R, additional, Rodondi, N, additional, Di Valentino, M, additional, Kobza, R, additional, De Perna, M.L, additional, Bonati, L.H, additional, Beer, J.H, additional, Kuehne, M, additional, Osswald, S, additional, and Conen, D, additional

Published
2020
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17. The Admit-AF risk score: a clinical risk score for predicting hospital admissions in patients with atrial fibrillation

Author

Meyre, P, primary, Aeschbacher, S, additional, Blum, S, additional, Coslovsky, M, additional, Beer, J.H, additional, Moschovitis, G, additional, Rodondi, N, additional, Baretella, O, additional, Kobza, R, additional, Sticherling, C, additional, Bonati, L.H, additional, Schwenkglenks, M, additional, Kuehne, M, additional, Osswald, S, additional, and Conen, D, additional

Published
2020
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20. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author

Sawhney, Jitendra PS., primary, Kothiwale, Veerappa A., additional, Bisne, Vikas, additional, Durgaprasad, Rajashekhar, additional, Jadhav, Praveen, additional, Chopda, Manoj, additional, Vanajakshamma, Velam, additional, Meena, Ramdhan, additional, Vijayaraghavan, Govindan, additional, Chawla, Kamaldeep, additional, Allu, Jagan, additional, Pieper, Karen S., additional, John Camm, A., additional, Kakkar, Ajay K., additional, Bassand, Jean-Pierre, additional, Fitzmaurice, David A., additional, Goldhaber, Samuel Z., additional, Goto, Shinya, additional, Haas, Sylvia, additional, Hacke, Werner, additional, Mantovani, Lorenzo G., additional, Misselwitz, Frank, additional, Turpie, Alexander G.G., additional, van Eickels, Martin, additional, Verheugt, Freek W.A., additional, Kayani, Gloria, additional, Fox, Keith A.A., additional, Gersh, Bernard J., additional, Luciardi, Hector Lucas, additional, Gibbs, Harry, additional, Brodmann, Marianne, additional, Cools, Frank, additional, Barretto, Antonio Carlos Pereira, additional, Connolly, Stuart J., additional, Spyropoulos, Alex, additional, Eikelboom, John, additional, Corbalan, Ramon, additional, Hu, Dayi, additional, Jansky, Petr, additional, Nielsen, Jørn Dalsgaard, additional, Ragy, Hany, additional, Raatikainen, Pekka, additional, Le Heuzey, Jean-Yves, additional, Darius, Harald, additional, Keltai, Matyas, additional, Kakkar, Sanjay, additional, Sawhney, Jitendra Pal Singh, additional, Agnelli, Giancarlo, additional, Ambrosio, Giuseppe, additional, Koretsune, Yukihiro, additional, Sánchez Díaz, Carlos Jerjes, additional, Ten Cate, Hugo, additional, Atar, Dan, additional, Stepinska, Janina, additional, Panchenko, Elizaveta, additional, Lim, Toon Wei, additional, Jacobson, Barry, additional, Oh, Seil, additional, Viñolas, Xavier, additional, Rosenqvist, Marten, additional, Steffel, Jan, additional, Angchaisuksiri, Pantep, additional, Oto, Ali, additional, Parkhomenko, Alex, additional, Al Mahmeed, Wael, additional, Fitzmaurice, David, additional, Hu, D.Y., additional, Chen, K.N., additional, Zhao, Y.S., additional, Zhang, H.Q., additional, Chen, J.Z., additional, Cao, S.P., additional, Wang, D.W., additional, Yang, Y.J., additional, Li, W.H., additional, Yin, Y.H., additional, Tao, G.Z., additional, Yang, P., additional, Chen, Y.M., additional, He, S.H., additional, Wang, Ying, additional, Wang, Yong, additional, Fu, G.S., additional, Li, X., additional, Wu, T.G., additional, Cheng, X.S., additional, Yan, X.W., additional, Zhao, R.P., additional, Chen, M.S., additional, Xiong, L.G., additional, Chen, P., additional, Jiao, Y., additional, Guo, Y., additional, Xue, L., additional, Wang, F.Z., additional, Li, H., additional, Yang, Z.M., additional, Bai, C.L., additional, Chen, J., additional, Chen, J.Y., additional, Chen, X., additional, Feng, S., additional, Fu, Q.H., additional, Gao, X.J., additional, Guo, W.N., additional, He, R.H., additional, He, X.A., additional, Hu, X.S., additional, Huang, X.F., additional, Li, B., additional, Li, J., additional, Li, L., additional, Li, Y.H., additional, Liu, T.T., additional, Liu, W.L., additional, Liu, Y.Y., additional, Lu, Z.C., additional, Luo, X.L., additional, Ma, T.Y., additional, Peng, J.Q., additional, Sheng, X., additional, Shi, X.J., additional, Sun, Y.H., additional, Tian, G., additional, Wang, K., additional, Wang, L., additional, Wu, R.N., additional, Xie, Q., additional, Xu, R.Y., additional, Yang, J.S., additional, Yang, L.L., additional, Yang, Q., additional, Ye, Y., additional, Yu, H.Y., additional, Yu, J.H., additional, Yu, T., additional, Zhai, H., additional, Zhan, Q., additional, Zhang, G.S., additional, Zhang, Q., additional, Zhang, R., additional, Zhang, Y., additional, Zheng, W.Y., additional, Zhou, B., additional, Zhou, Z.H., additional, Zhu, X.Y., additional, Kakkar, S., additional, Sawhney, J.P.S., additional, Jadhav, P., additional, Durgaprasad, R., additional, Ravi Shankar, A.G., additional, Rajput, R.K., additional, Bhargava, K., additional, Sarma, R., additional, Srinivas, A., additional, Roy, D., additional, Nagamalesh, U.M., additional, Chopda, M., additional, Kishore, R., additional, Kulkarni, G., additional, Chandwani, P., additional, Pothiwala, R.A., additional, Padinhare Purayil, M., additional, Shah, S., additional, Chawla, K., additional, Kothiwale, V.A., additional, Raghuraman, B., additional, Vijayaraghavan, G., additional, Vijan, V.M., additional, Bantwal, G., additional, Bisne, V., additional, Khan, A., additional, Gupta, J.B., additional, Kumar, S., additional, Jain, D., additional, Abraham, S., additional, Adak, D., additional, Barai, A., additional, Begum, H., additional, Bhattacharjee, P., additional, Dargude, M., additional, Davies, D., additional, Deshpande, B., additional, Dhakrao, P., additional, Dhyani, V., additional, Duhan, S., additional, Earath, M., additional, Ganatra, A., additional, Giradkar, S., additional, Jain, V., additional, Karthikeyan, R., 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additional, Gimenez, C.H., additional, Gurfinkel, E.P., additional, de L.M. 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Pozas, G., additional, Cardona Muñoz, E., additional, Matadamas Hernández, N., additional, Leyva Rendón, A., additional, García Hernández, N., additional, de los Ríos Ibarra, M., additional, Virgen Carrillo, L., additional, López Villezca, D., additional, Hernández Herrera, C., additional, López Prieto, J.J., additional, Gaona Rodríguez, R., additional, Villeda Espinosa, E., additional, Flores Martínez, D., additional, Velasco Barcena, J., additional, Yong, R., additional, Rodríguez Briones, I., additional, Leiva Pons, J.L., additional, Álvarez López, H., additional, Olvera Ruiz, R., additional, Díaz de la Vega, C., additional, Cantú Brito, C., additional, Chuquiure Valenzuela, E., additional, Reyes-Sanchez, R., additional, Bazzoni Ruiz, A., additional, Nandayapa Flores, O., additional, Benavides Gonzalez, M., additional, Arriaga Nava, R., additional, Morales Cerda, J.D., additional, Fierro Fierro, O., additional, Fajardo Campos, P., additional, Alfaro, T.A.A., additional, Altamirano 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Mitrovic, V., additional, Babjakova, Z., additional, Bergner, K., additional, Boehme, S., additional, Bonin, K., additional, Buckert, D., additional, Busch, F., additional, Dichristin, U., additional, Diez, S., additional, Fleck, A., additional, Flint, K., additional, Floegel, H., additional, Fritz, C., additional, Frommhold, R., additional, Gehre, J., additional, Geyer, J., additional, Grytzmann, A., additional, Hahn, M., additional, Helgert, K., additional, Hubert, K., additional, Kirchner-Volker, K., additional, Klein, V., additional, Kroll, D., additional, Krueger, A., additional, Lehmann, R., additional, Mann, L., additional, Maselli, A., additional, Menken, G., additional, Mikes, K., additional, Mortan, H., additional, Nasser, N., additional, Nicolaus, D., additional, Plauskat, A., additional, Pomper, L., additional, Quietzsch, A., additional, Ravenhorst, C., additional, Reichelt, C., additional, Reimer, C., additional, Schaefer, B., additional, Scharrer, S., additional, 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El Din, M.G., additional, El Etriby, S., additional, Elbahry, A., additional, El-Etreby, A., additional, Elkhadem, M., additional, Katta, A., additional, Khairy, T., additional, Mowafy, A., additional, Nawar, M., additional, Ohanissian, A., additional, Reda, A., additional, Reda, M., additional, Salem, H., additional, Sami, N., additional, Samir, S., additional, Setiha, M., additional, Sobhy, M., additional, Soliman, A., additional, Taha, N., additional, Tawfik, M., additional, Zaatout, E., additional, Kettles, D., additional, Bayat, J., additional, Siebert, H., additional, Horak, A., additional, Kelfkens, Y., additional, Garda, R., additional, Pillay, T., additional, Guerra, M., additional, van Zyl, L., additional, Theron, H., additional, Murray, A., additional, Louw, R., additional, Greyling, D., additional, Mntla, P., additional, Ueckermann, V., additional, Loghdey, R., additional, Ismail, S., additional, Ahmed, F., additional, Engelbrecht, J., additional, Ramdass, A., additional, Maharajh, S., additional, Oosthuysen, W., additional, Angel, G., additional, Bester, C., additional, Booysen, M., additional, Boshoff, C., additional, Cannon, C., additional, Cassimjee, S., additional, Chami, C., additional, Conway, G., additional, Davids, A., additional, de Meyer, L., additional, Du Plessis, G., additional, Ellis, T., additional, Henley, L., additional, Karsten, M., additional, Loyd, E., additional, Marks, J., additional, Mavhusa, L., additional, Mostert, M., additional, Page, A., additional, Rikhotso, L., additional, Salie, M., additional, Sasto, J., additional, Shaik, F., additional, Skein, A., additional, Smith, L., additional, Tarr, G., additional, Tau, T., additional, van Zyl, F., additional, Al Mahmeed, W., additional, Yousef, G., additional, Agrawal, A., additional, Nathani, M., additional, Ibrahim, M., additional, Esheiba, E.M., additional, Singh, R., additional, Naguib, A., additional, Abu-Mahfouz, M., additional, Al Omairi, M., additional, Al Naeemi, A., additional, Maruthanayagam, R., additional, Bazargani, N., additional, Wassef, A., additional, Gupta, R., additional, Khan, M., additional, Subbaraman, B., additional, Abdul, A., additional, Al Mulla, A., additional, El Bardisy, S., additional, Haridas, P., additional, Jadhav, S., additional, Magdaluyo, K., additional, Makdad, M., additional, Maqsood, I., additional, Mohamed, R., additional, Sharma, N., additional, Sharma, R., additional, Thanzeel, M., additional, Goldhaber, S.Z., additional, Canosa, R., additional, Rama, P., additional, Blumberg, E., additional, Garcia, J., additional, Mullen, P., additional, Wilson, V., additional, Quick, A., additional, Ferrick, K., additional, Kutayli, W.M., additional, Cox, M., additional, Franco, M., additional, Falkowski, S., additional, Mendelson, R., additional, Williams, M., additional, Miller, S., additional, Beach, S., additional, Alfieri, A., additional, Gutowski, T., additional, Haque, I., additional, Reddy, R., additional, Ahmed, W., additional, Delafontaine, P., additional, Diercks, D., additional, Theodoro, D., additional, Remmel, K., additional, Alberts, M., additional, Ison, R., additional, Noveck, H., additional, Duffy, P., additional, Pitta, S., additional, Nishijima, D., additional, Treasure, C., additional, Asafu-Adjaye, N., additional, Ball, K., additional, Bartlett, M., additional, Bentley, M., additional, Bowers, S., additional, Brown, A., additional, Browne, A., additional, Cameron-Watts, J., additional, Canova, M., additional, Cassidy, D., additional, Cervellione, K., additional, Congal, S., additional, DePauw, J., additional, Dickerson, A., additional, Eley, M., additional, Evans, L., additional, Felpel, S., additional, Ferdinand, K., additional, Fielder, D., additional, Gentry, P., additional, Haideri, A., additional, Hakimi, F., additional, Harbour, T., additional, Hartranft, E., additional, Hawkins, B., additional, Headlee, M., additional, Henson, L., additional, Herrick, C., additional, Hicks, T., additional, Jasinski, S., additional, Jones, A., additional, Jones, L., additional, Jones, P., additional, Karl, S., additional, Keeling, M., additional, Kerr, J., additional, Knowles, P., additional, Langdon, J., additional, Lay, M., additional, Lee, J.A., additional, Lincoln, T., additional, Malone, E., additional, Merliss, A., additional, Merritt, D., additional, Minardo, J., additional, Mooso, B., additional, Orosco, C., additional, Palumbo, V., additional, Parker, M., additional, Parrott, T., additional, Paserchia, S., additional, Pearl, G., additional, Peterson, J., additional, Pickelsimer, N., additional, Purcell, T., additional, Raynor, J., additional, Raziano, S., additional, Richard, C., additional, Richardson, T., additional, Robertson, C., additional, Sage, A., additional, Sanghera, T., additional, Shaw, P., additional, Shoemaker, J., additional, Smith, K., additional, Stephanie, B., additional, Thatcher, A., additional, Theobald, H., additional, Thompson, N., additional, Treasure, L., additional, Tripti, T., additional, Verdi, C., additional, and Worthy, V., additional

Published
2018
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22. Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

Author

Spescha, R.D., Klohs, J., Semerano, A., Giacalone, G., Derungs, R.S., Reiner, M.F., Rodriguez Gutierrez, D., Mendez-Carmona, N., Glanzmann, M., Savarese, G., Kränkel, N., Akhmedov, A., Keller, S., Mocharla, P., Kaufmann, M.R., Wenger, R.H., Vogel, J., Kulic, L., Nitsch, R.M., Beer, J.H., Peruzzotti-Jametti, L., Sessa, M., Lüscher, T.F., Camici, G.G., Spescha, R.D., Klohs, J., Semerano, A., Giacalone, G., Derungs, R.S., Reiner, M.F., Rodriguez Gutierrez, D., Mendez-Carmona, N., Glanzmann, M., Savarese, G., Kränkel, N., Akhmedov, A., Keller, S., Mocharla, P., Kaufmann, M.R., Wenger, R.H., Vogel, J., Kulic, L., Nitsch, R.M., Beer, J.H., Peruzzotti-Jametti, L., Sessa, M., Lüscher, T.F., and Camici, G.G.

Abstract

In light of the limited repertoire of therapeutical options available for the treatment of ischaemic stroke, the identification of novel potential targets is vital; in this respect, the present study demonstrates that the adaptor protein p66Shc holds this potential as an adjunct therapy to thrombolysis. Post-ischaemic silencing of p66Shc protein yielded beneficial effects in a mouse model of I/R brain injury underlying an interesting translational perspective for this target protein. Further, in proof-of-principle clinical experiments using PBMs, we demonstrate that p66Shc gene expression is transiently increased and that its levels correlate to short-term outcome in ischaemic stroke patients. Although these latter experiments are not directly relevant to the experiments performed in mice and in human endothelial cells, they provide novel important information about p66Shc regulation in stroke patients and set the basis for further investigations aimed at assessing the potential for p66Shc to become a novel therapeutic target as an adjunct of thrombolysis for the management of acute ischaemic stroke

Published
2017

23. P5320Trimethylamine-N-oxide (TMAO) Predicts Total Mortality, but not Recurrent Venous Thromboembolism in Elderly Patients with Acute Venous Thromboembolism

Author

Reiner, M.F., primary, Mueller, D., additional, Gobbato, S., additional, Stalder, O., additional, Limacher, A., additional, Bonetti, N., additional, Stivala, S., additional, Mean, M., additional, Rodondi, N., additional, Aujesky, D., additional, Luescher, T.F., additional, Camici, G.G., additional, Von Eckardstein, A., additional, and Beer, J.H., additional

Published
2017
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26. Bone marrow-specific Sirt6 deletion increases atherogenesis by increasing macrophage scavenger receptor 1

Author

Arsiwala, T., primary, van Tits, L.J., additional, Miranda, M., additional, Nussbaum, K., additional, Weber, J., additional, Stivala, S., additional, Beer, J.H., additional, Greter, M., additional, Becher, B., additional, Hottiger, M.O., additional, Mostoslavsky, R., additional, Auwerx, J., additional, Lüscher, T.F., additional, and Matter, C.M., additional

Published
2016
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27. Post-ischaemic silencing of p66Shcreduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

Author

Spescha, R.D., primary, Klohs, J., additional, Semerano, A., additional, Giacalone, G., additional, Derungs, R.S., additional, Reiner, M.F., additional, Rodriguez Gutierrez, D., additional, Mendez-Carmona, N., additional, Glanzmann, M., additional, Savarese, G., additional, Kränkel, N., additional, Akhmedov, A., additional, Keller, S., additional, Mocharla, P., additional, Kaufmann, M.R., additional, Wenger, R.H., additional, Vogel, J., additional, Kulic, L., additional, Nitsch, R.M., additional, Beer, J.H., additional, Peruzzotti-Jametti, L., additional, Sessa, M., additional, Lüscher, T.F., additional, and Camici, G.G., additional

Published
2015
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33. Tectonic model for the evolution of the Limpopo Belt

Author

Roering, C., primary, van Reenen, D.D., additional, Smit, C.A., additional, Barton, J.M., additional, de Beer, J.H., additional, de Wit, M.J., additional, Stettler, E.H., additional, van Schalkwyk, J.F., additional, Stevens, G., additional, and Pretorius, S., additional

Published
1992
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37. Book Reviews

Author

Beek, Walter E.A., primary, Ufford, Ph. Quarles, additional, Beer, J.H., additional, Tillema, H.F., additional, Beet, Chris, additional, Price, Richard, additional, Bos, G., additional, Whitehead, Neil L., additional, Brandon, James R., additional, Schechner, Richard, additional, Breetvelt, J.N., additional, Kamppinen, Matti, additional, Bruinessen, Martin, additional, Woodward, Mark R., additional, Casparis, J.G., additional, Scheurleer, Pauline Lunsingh, additional, Mendes, Hugo Fernandes, additional, Alofs, Luc, additional, Haar, Rene, additional, Eibl-Eibesfeldt, I., additional, Heins, M., additional, Epskamp, K., additional, Jonge, Huub, additional, Höllman, Thomas, additional, Jonge, Nico, additional, Kis-Jovak, Jowa Imre, additional, Laeyendecker, L., additional, Alexander, Jeffrey C., additional, Lindblad, Thomas, additional, Segers, W.A.I.M., additional, Meer, C.L.J., additional, Suehiro, Akira, additional, Mulder, Niels, additional, Eberhardt, Nancy, additional, Oostindie, Gert, additional, Nederveen Pieterse, Jan, additional, Corbey, Raymond, additional, Ploeg, R., additional, Clendinnen, Inga, additional, Robson, S.O., additional, Santa Maria, Luigi, additional, Römer, R.A., additional, Schrils, J.M.R., additional, Rueb, Patricia D., additional, and Brummelhuis, Han, additional

Published
1991
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38. False positive results for leucocytes in urine dipstick test with common antibiotics

Author

Beer, J.H., Vogt, A., Neftel, K., and Cottagnoud, P.

Subjects
Urine -- Analysis, False positive reactions -- Analysis -- Physiological aspects, Antibiotics -- Physiological aspects -- Analysis, Health, Analysis, Physiological aspects
Abstract

We found positive results for leucocyte esterase in the dipstick test in two patients with acute leukaemia who had had documented aplasia for several days. They were treated with imipenem [...]

Published
1996

40. Structures related to the Antimony line, Murchison schist belt, Kaapvaal craton, South Africa

Author

Vearncombe, J.R., Cheshire, P.E., De Beer, J.H., Killick, A.M., Mallinson, W.S., McCourt, S., and Stettler, E.H.

Abstract

Sporadic epigenetic antimony-gold mineralisation along the ENE-trending Antimony line of the Murchison schist belt is structurally controlled and spatially related to carbonated rock types with quartz-carbonate veins in tension fractures. The Antimony line is a discontinuous zone of brittle-ductile deformation and is locally oblique to lithological layering within a broad ductile shear zone. This tectonically early (D 1) shear zone has an oblique-to dip-slip, reverse (north-side-up) movement sense with downward-facing fold structures in the hangingwall. Later (D 2) fold structures deformed the Antimony line and its wallrocks into steep structures. The Antimony line is intruded by granitoids which post-date D 1and are not directly related to mineralisation, the source of which may have been metamorphic fluids.

Published
1988
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41. The southern cape conductive belt (South Africa): Its composition, origin and tectonic significance

Author

De Beer, J.H., Van Zijl, J.S.V., and Gough, D.I.

Abstract

Magnetometer array studies have led to the discovery and mapping of the Southern Cape Conductive Belt (SCCB) crossing the southern tip of Africa from west to southeast coasts. The SCCB lies just south of the Namaqua-Natal Belt of cratonic rocks remobilized about 1000 m.y. B.P. It is shown that it coincides with a zone of weakness which has been exploited by three major geosynclinal accumulations over some 600 m.y. Relationships between the SCCB and the basement geochronology, geology and tectonics are considered in detail. These relationships support the view that the conductive belt was formed by an accumulation of marine sediments and oceanic lithosphere at the top of a Proterozoic subduction which stopped about 1000 to 800 m.y. B.P. Associated with this subduction we propose a Proterozoic range of Andean mountains, whose roots are now exposed in the Namaqua-Natal Belt. Later subduction further south, near the present south coast, is proposed to account for the intrusion, between the south coast and the SCCB, of the Cape Granites in the time interval 600-500 m.y. B.P. There is some evidence for a third, yet more distant, subduction episode off Permian Gondwanaland. After outlining this tectonic history, the paper turns to a closer examination of the hypothesis that the Southern Cape Conductive Belt consists of partly serpentinized basalt accumulated at the top of a Proterozoic subduction. A large static magnetic anomaly, which correlates with the SCCB over most of its length, is well fitted by a model which strongly supports this hypothesis. Bouguer gravity anomalies along western and central profiles likewise support the hypothesis. A discussion follows of the process of formation of the proposed block of serpentinized marine rocks, beginning with serpentinization of the crust near oceanic ridges by reaction of warm, porous, newly-extruded basalt with seawater convecting through it. The serpentinized basalt is stable at crustal temperatures and pressures and so is transported in the seafloor until it reaches a subduction, where it accumulates because of its low density. Examples of such accumulations are cited. Finally, it is shown that any iron in the olivine and pyroxene in the original basalt precipitates, when these silicates are hydrated to serpentine, as magnetite which is the dominant mineral conferring high electrical conductivity and high magnetic susceptibility on serpentinites. In particular the Beattie static magnetic anomaly requires, in our model calculation, a very high susceptibility readily attainable in basalt at 15–20% serpentinization. The authors know of no other rock able to provide this high susceptibility. A similar percentage of serpentinization provides the density required to model the gravity anomalies.

Published
1982
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42. Glycocalicin: A New Assay—The Normal Plasma Levels and Its Potential Usefulness in Selected Diseases

Author

Beer, J.H., Buchi, L., and Steiner, B.

Abstract

Platelet glycocalicin (GC) is the extramembranous portion of GPIba that can be rapidly cleaved by enzymes such as calpain, plasmin, trypsin, elastase, etc. Quantitative cleavage will ultimately result in an acquired Bernard-Soulier-like bleeding disorder, and circulating GC may act as a potential inhibitor of platelet adhesion. We have developed and standardized a new enzyme-linked immunosorbent assay (ELISA), which uses two monoclonal antibodies (mAbs), both of which bind to the amino-terminal 45-kD fragment of GC and inhibit platelet-von Willebrand interactions and the streptavidin-biotin system. First, the methodology was evaluated and standardized with special emphasis on the anticoagulant and the inhibitors (EDTA, prostaglandin E, [PGE,], aprotinin, N-ethyl-maleimide), the mode of high-speed centrif ugation (to avoid platelet micro-particles), and the standards used (purified GPIb and GC). This assay was then used to analyze the GC levels of healthy subjects (2.04 ± 0.46 µg/mL) and of patients with selected diseases. The results of patients with aplastic anemia and thrombocytosis confirmed that GC levels are clearly dependent on the platelet count, which was the basis for the introduction of the GC index, the standardization of GC for a platelet count of 250 × 109/L The GC index discriminates reliably patients with active immune thrombocytopenic purpura from those in remission. GC levels are elevated in patients on hemodialysis (3.62 ± 0.75 µg/mL, P <.001). The high GC index (6.93 ± 4.21, P <.001) in cirrhosis patients suggests an increased platelet turnover and/or abnormal proteolysis. In contrast to other groups, we have not found that recombinant tissue plasminogen activator (rtPA) treatment of patients with myocardial infarction increases GC levels. However, concentrations are elevated in leukemia and the highest levels found are approximately 40 µg/mL. These studies suggest that GC is a useful platelet marker in certain diseases, which directly reflects platelet damage and possibly platelet dysfunction.

Published
1994
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43. Book Reviews

Author

Rueb, Patricia D., Eibl-Eibesfeldt, I., Suehiro, Akira, Price, Richard, Tillema, H.F., Whitehead, Neil L., Robson, S.O., Epskamp, K., Kis-Jovak, Jowa Imre, Eberhardt, Nancy, Corbey, Raymond, Haar, Rene, Mendes, Hugo Fernandes, Brummelhuis, Han, Lindblad, Thomas, Ufford, Ph. Quarles, Bos, G., Beet, Chris, Brandon, James R., Breetvelt, J.N., Segers, W.A.I.M., Casparis, J.G., Bruinessen, Martin, Schrils, J.M.R., Santa Maria, Luigi, Jonge, Huub, Laeyendecker, L., Heins, M., Jonge, Nico, Oostindie, Gert, Ploeg, R., Alofs, Luc, Beer, J.H., Beek, Walter E.A., Clendinnen, Inga, Meer, C.L.J., Kamppinen, Matti, Scheurleer, Pauline Lunsingh, Schechner, Richard, Woodward, Mark R., Römer, R.A., Höllman, Thomas, Alexander, Jeffrey C., Nederveen Pieterse, Jan, Mulder, Niels, and Oostindie, Gert

Published
1991
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44. Gravity and geoelectrical studies of the Murchison greenstone belt, South Africa.

Author

De Beer J.H., Duvenhage A.W.A., Joubert S.J., Raath C.J. de W., Stettler E.H., De Beer J.H., Duvenhage A.W.A., Joubert S.J., Raath C.J. de W., and Stettler E.H.

Abstract

The aim of the geophysical research was to determine the three-dimensional structure of the greenstone belt and to try to establish correlation between mineralisation and structural features. The Gravelotte Group was found to have an electrical resistivity between 1000 - 3000 ohms m whereas values for the Rooiwater Complex and the granite-gneiss complex exceed 10 000 chms m. Maximum depth extent for the Gravelotte Group is indicated at between 8.8 and 12.3 km, while most of the belt has a depth less than 4.5 km. The Bouger anomaly map shows that positive gravity anomalies are associated with the Murchison sequence. It is clear that the thickest part of the Rooiwater Complex is offset in a left-lateral sense with respect to the thickest part of the Gravelotte Group and that the entire Murchison Sequence seems to be affected by left-lateral shearing. The Free State Diorite and the late-stage Maranda and Baderoukwe granite plutons seem to be intruded into shear zones., The aim of the geophysical research was to determine the three-dimensional structure of the greenstone belt and to try to establish correlation between mineralisation and structural features. The Gravelotte Group was found to have an electrical resistivity between 1000 - 3000 ohms m whereas values for the Rooiwater Complex and the granite-gneiss complex exceed 10 000 chms m. Maximum depth extent for the Gravelotte Group is indicated at between 8.8 and 12.3 km, while most of the belt has a depth less than 4.5 km. The Bouger anomaly map shows that positive gravity anomalies are associated with the Murchison sequence. It is clear that the thickest part of the Rooiwater Complex is offset in a left-lateral sense with respect to the thickest part of the Gravelotte Group and that the entire Murchison Sequence seems to be affected by left-lateral shearing. The Free State Diorite and the late-stage Maranda and Baderoukwe granite plutons seem to be intruded into shear zones.

45. Geology, geophysics and mineralisation of the Murchison schist belt, Rooiwater Complex and surrounding granitoids.

Author

Vearncombe J.R., Barton J.M., Brandl G., Cheshire P.E., De Beer J.H., Stettler E.H., Vearncombe J.R., Barton J.M., Brandl G., Cheshire P.E., De Beer J.H., and Stettler E.H.

Abstract

Results are presented from comprehensive geological mapping at a scale of 1:50 000 and other geological and geophysical research investigations. The Murchison belt is considered as five domains defined by lithological, metamorphic and structural characteristics: Silwana amphibolite, Rooiwater Complex, Rubbervale Formation, Murchison ultramafic, mafic, carbonated and metasedimentary schists, and La France Formation. The Rubbervale Formation comprises a quartz-porphyroclastic schist derived from a quartz-feldspar porphyry, overlain by felsic volcanic schists with sporadic massive Zn-Cu sulphide deposits. Sb-Au mineralisation is epigenetic and occurs along a narrow deformation zone known as the Antimony Line. It comprises a central, semi-brittle deformation zone within a broad ductile shear zone with oblique to dip-slip movement sense. The ductile shear zone and semi-brittle Antimony Line tectonism developed early (D1) in the deformation history of the schist belt. The country and host rocks of the Antimony Line and its mineralisation are all metamorphosed in green-schist facies, and some are intensely altered. Two stages in the evolution of the Antimony Line mineralisation are recognised: a major D1 introduction and syntectonic concentration of stibnite and related mineralisation in brittle fractures and boudin neckes in massive rocks, and in foliation-parallel veins in schists; and minor tectonic remobilisation and vein development subsequent to D1., Results are presented from comprehensive geological mapping at a scale of 1:50 000 and other geological and geophysical research investigations. The Murchison belt is considered as five domains defined by lithological, metamorphic and structural characteristics: Silwana amphibolite, Rooiwater Complex, Rubbervale Formation, Murchison ultramafic, mafic, carbonated and metasedimentary schists, and La France Formation. The Rubbervale Formation comprises a quartz-porphyroclastic schist derived from a quartz-feldspar porphyry, overlain by felsic volcanic schists with sporadic massive Zn-Cu sulphide deposits. Sb-Au mineralisation is epigenetic and occurs along a narrow deformation zone known as the Antimony Line. It comprises a central, semi-brittle deformation zone within a broad ductile shear zone with oblique to dip-slip movement sense. The ductile shear zone and semi-brittle Antimony Line tectonism developed early (D1) in the deformation history of the schist belt. The country and host rocks of the Antimony Line and its mineralisation are all metamorphosed in green-schist facies, and some are intensely altered. Two stages in the evolution of the Antimony Line mineralisation are recognised: a major D1 introduction and syntectonic concentration of stibnite and related mineralisation in brittle fractures and boudin neckes in massive rocks, and in foliation-parallel veins in schists; and minor tectonic remobilisation and vein development subsequent to D1.

46. Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

Author

Spescha, R.D., Klohs, J., Semerano, A., Giacalone, G., Derungs, R.S., Reiner, M.F., Rodriguez Gutierrez, D., Mendez-Carmona, N., Glanzmann, M., Savarese, G., Kränkel, N., Akhmedov, A., Keller, S., Mocharla, P., Kaufmann, M.R., Wenger, R.H., Vogel, J., Kulic, L., Nitsch, R.M., Beer, J.H., Peruzzotti-Jametti, L., Sessa, M., Lüscher, T.F., Camici, G.G., Spescha, R.D., Klohs, J., Semerano, A., Giacalone, G., Derungs, R.S., Reiner, M.F., Rodriguez Gutierrez, D., Mendez-Carmona, N., Glanzmann, M., Savarese, G., Kränkel, N., Akhmedov, A., Keller, S., Mocharla, P., Kaufmann, M.R., Wenger, R.H., Vogel, J., Kulic, L., Nitsch, R.M., Beer, J.H., Peruzzotti-Jametti, L., Sessa, M., Lüscher, T.F., and Camici, G.G.

Abstract

In light of the limited repertoire of therapeutical options available for the treatment of ischaemic stroke, the identification of novel potential targets is vital; in this respect, the present study demonstrates that the adaptor protein p66Shc holds this potential as an adjunct therapy to thrombolysis. Post-ischaemic silencing of p66Shc protein yielded beneficial effects in a mouse model of I/R brain injury underlying an interesting translational perspective for this target protein. Further, in proof-of-principle clinical experiments using PBMs, we demonstrate that p66Shc gene expression is transiently increased and that its levels correlate to short-term outcome in ischaemic stroke patients. Although these latter experiments are not directly relevant to the experiments performed in mice and in human endothelial cells, they provide novel important information about p66Shc regulation in stroke patients and set the basis for further investigations aimed at assessing the potential for p66Shc to become a novel therapeutic target as an adjunct of thrombolysis for the management of acute ischaemic stroke

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